-- dump date   	20140618_203914
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
290397000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
290397000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
290397000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000004	Walker A motif; other site
290397000005	ATP binding site [chemical binding]; other site
290397000006	Walker B motif; other site
290397000007	arginine finger; other site
290397000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
290397000009	DnaA box-binding interface [nucleotide binding]; other site
290397000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
290397000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
290397000012	putative DNA binding surface [nucleotide binding]; other site
290397000013	dimer interface [polypeptide binding]; other site
290397000014	beta-clamp/clamp loader binding surface; other site
290397000015	beta-clamp/translesion DNA polymerase binding surface; other site
290397000016	recombination protein F; Reviewed; Region: recF; PRK00064
290397000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397000018	Walker A/P-loop; other site
290397000019	ATP binding site [chemical binding]; other site
290397000020	Q-loop/lid; other site
290397000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397000022	ABC transporter signature motif; other site
290397000023	Walker B; other site
290397000024	D-loop; other site
290397000025	H-loop/switch region; other site
290397000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
290397000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000028	ATP binding site [chemical binding]; other site
290397000029	Mg2+ binding site [ion binding]; other site
290397000030	G-X-G motif; other site
290397000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
290397000032	anchoring element; other site
290397000033	dimer interface [polypeptide binding]; other site
290397000034	ATP binding site [chemical binding]; other site
290397000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
290397000036	active site
290397000037	putative metal-binding site [ion binding]; other site
290397000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
290397000039	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
290397000040	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
290397000041	dimer interface [polypeptide binding]; other site
290397000042	active site
290397000043	CoA binding pocket [chemical binding]; other site
290397000044	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
290397000045	active site
290397000046	Zn binding site [ion binding]; other site
290397000047	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290397000048	Cysteine-rich domain; Region: CCG; pfam02754
290397000049	Cysteine-rich domain; Region: CCG; pfam02754
290397000050	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
290397000051	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397000052	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
290397000053	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397000054	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
290397000055	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397000056	active site
290397000057	HIGH motif; other site
290397000058	nucleotide binding site [chemical binding]; other site
290397000059	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
290397000060	active site
290397000061	KMSKS motif; other site
290397000062	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
290397000063	tRNA binding surface [nucleotide binding]; other site
290397000064	anticodon binding site; other site
290397000065	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
290397000066	lipoprotein signal peptidase; Provisional; Region: PRK14773
290397000067	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
290397000068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397000069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000070	ATP binding site [chemical binding]; other site
290397000071	Mg2+ binding site [ion binding]; other site
290397000072	G-X-G motif; other site
290397000073	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397000074	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
290397000075	active site
290397000076	metal binding site [ion binding]; metal-binding site
290397000077	prolyl-tRNA synthetase; Provisional; Region: PRK08661
290397000078	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
290397000079	dimer interface [polypeptide binding]; other site
290397000080	motif 1; other site
290397000081	active site
290397000082	motif 2; other site
290397000083	motif 3; other site
290397000084	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
290397000085	anticodon binding site; other site
290397000086	zinc-binding site [ion binding]; other site
290397000087	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
290397000088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397000089	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290397000090	NAD(P) binding site [chemical binding]; other site
290397000091	active site
290397000092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397000093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397000094	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397000095	dimerization interface [polypeptide binding]; other site
290397000096	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
290397000097	Cache domain; Region: Cache_2; cl07034
290397000098	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397000100	dimerization interface [polypeptide binding]; other site
290397000101	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397000102	dimer interface [polypeptide binding]; other site
290397000103	putative CheW interface [polypeptide binding]; other site
290397000104	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290397000105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397000106	NAD(P) binding site [chemical binding]; other site
290397000107	active site
290397000108	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
290397000109	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397000110	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
290397000111	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
290397000112	Na binding site [ion binding]; other site
290397000113	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397000114	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
290397000115	acyl-activating enzyme (AAE) consensus motif; other site
290397000116	AMP binding site [chemical binding]; other site
290397000117	active site
290397000118	CoA binding site [chemical binding]; other site
290397000119	ACT domain-containing protein [General function prediction only]; Region: COG4747
290397000120	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
290397000121	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
290397000122	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
290397000123	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397000124	acyl-activating enzyme (AAE) consensus motif; other site
290397000125	AMP binding site [chemical binding]; other site
290397000126	active site
290397000127	CoA binding site [chemical binding]; other site
290397000128	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
290397000129	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290397000130	PYR/PP interface [polypeptide binding]; other site
290397000131	TPP binding site [chemical binding]; other site
290397000132	dimer interface [polypeptide binding]; other site
290397000133	substrate binding site [chemical binding]; other site
290397000134	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
290397000135	TPP-binding site; other site
290397000136	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
290397000137	butyrate kinase; Provisional; Region: PRK03011
290397000138	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
290397000139	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
290397000140	DNA-binding site [nucleotide binding]; DNA binding site
290397000141	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397000142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397000143	homodimer interface [polypeptide binding]; other site
290397000144	catalytic residue [active]
290397000145	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
290397000146	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
290397000147	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290397000148	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
290397000149	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
290397000150	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
290397000151	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
290397000152	Ligand binding site [chemical binding]; other site
290397000153	Electron transfer flavoprotein domain; Region: ETF; pfam01012
290397000154	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
290397000155	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
290397000156	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
290397000157	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397000158	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
290397000159	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
290397000160	EamA-like transporter family; Region: EamA; pfam00892
290397000161	EamA-like transporter family; Region: EamA; pfam00892
290397000162	MltA specific insert domain; Region: MltA; smart00925
290397000163	3D domain; Region: 3D; pfam06725
290397000164	uracil transporter; Provisional; Region: PRK10720
290397000165	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
290397000166	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
290397000167	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397000168	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397000169	RNA binding surface [nucleotide binding]; other site
290397000170	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397000171	active site
290397000172	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
290397000173	Transglycosylase; Region: Transgly; pfam00912
290397000174	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
290397000175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397000176	dimerization interface [polypeptide binding]; other site
290397000177	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397000178	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397000179	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397000180	dimer interface [polypeptide binding]; other site
290397000181	putative CheW interface [polypeptide binding]; other site
290397000182	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
290397000183	EVE domain; Region: EVE; pfam01878
290397000184	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
290397000185	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
290397000186	putative acyltransferase; Provisional; Region: PRK05790
290397000187	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
290397000188	dimer interface [polypeptide binding]; other site
290397000189	active site
290397000190	DNA translocase FtsK; Provisional; Region: PRK10263
290397000191	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
290397000192	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
290397000193	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
290397000194	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
290397000195	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
290397000196	active site
290397000197	oxyanion hole [active]
290397000198	catalytic triad [active]
290397000199	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290397000200	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
290397000201	inhibitor-cofactor binding pocket; inhibition site
290397000202	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397000203	catalytic residue [active]
290397000204	AAA domain; Region: AAA_26; pfam13500
290397000205	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
290397000206	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
290397000207	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
290397000208	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397000209	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397000210	protein binding site [polypeptide binding]; other site
290397000211	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397000212	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290397000213	active site
290397000214	pyrophosphate binding site [ion binding]; other site
290397000215	thiamine phosphate binding site [chemical binding]; other site
290397000216	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
290397000217	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
290397000218	catalytic triad [active]
290397000219	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290397000220	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
290397000221	replicative DNA helicase; Region: DnaB; TIGR00665
290397000222	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
290397000223	Walker A motif; other site
290397000224	ATP binding site [chemical binding]; other site
290397000225	Walker B motif; other site
290397000226	DNA binding loops [nucleotide binding]
290397000227	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
290397000228	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
290397000229	LrgB-like family; Region: LrgB; cl00596
290397000230	LrgA family; Region: LrgA; pfam03788
290397000231	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397000232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397000233	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
290397000234	putative dimerization interface [polypeptide binding]; other site
290397000235	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
290397000236	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
290397000237	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
290397000238	substrate binding pocket [chemical binding]; other site
290397000239	dimer interface [polypeptide binding]; other site
290397000240	inhibitor binding site; inhibition site
290397000241	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290397000242	B12 binding site [chemical binding]; other site
290397000243	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
290397000244	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
290397000245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397000246	FeS/SAM binding site; other site
290397000247	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
290397000248	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
290397000249	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
290397000250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397000251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397000252	dimer interface [polypeptide binding]; other site
290397000253	phosphorylation site [posttranslational modification]
290397000254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000255	ATP binding site [chemical binding]; other site
290397000256	Mg2+ binding site [ion binding]; other site
290397000257	G-X-G motif; other site
290397000258	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
290397000259	Hemerythrin; Region: Hemerythrin; cd12107
290397000260	Fe binding site [ion binding]; other site
290397000261	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
290397000262	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290397000263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397000264	FeS/SAM binding site; other site
290397000265	TRAM domain; Region: TRAM; cl01282
290397000266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
290397000267	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
290397000268	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
290397000269	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
290397000270	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
290397000271	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
290397000272	Part of AAA domain; Region: AAA_19; pfam13245
290397000273	Family description; Region: UvrD_C_2; pfam13538
290397000274	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
290397000275	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
290397000276	active site
290397000277	purine riboside binding site [chemical binding]; other site
290397000278	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
290397000279	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
290397000280	DNA binding site [nucleotide binding]
290397000281	active site
290397000282	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
290397000283	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
290397000284	ligand binding site; other site
290397000285	oligomer interface; other site
290397000286	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
290397000287	dimer interface [polypeptide binding]; other site
290397000288	N-terminal domain interface [polypeptide binding]; other site
290397000289	sulfate 1 binding site; other site
290397000290	Response regulator receiver domain; Region: Response_reg; pfam00072
290397000291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397000292	active site
290397000293	phosphorylation site [posttranslational modification]
290397000294	intermolecular recognition site; other site
290397000295	dimerization interface [polypeptide binding]; other site
290397000296	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397000297	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397000298	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397000299	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397000300	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397000301	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290397000302	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397000303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397000304	active site
290397000305	phosphorylation site [posttranslational modification]
290397000306	intermolecular recognition site; other site
290397000307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000308	Walker A motif; other site
290397000309	ATP binding site [chemical binding]; other site
290397000310	Walker B motif; other site
290397000311	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397000312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397000313	dimer interface [polypeptide binding]; other site
290397000314	phosphorylation site [posttranslational modification]
290397000315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000316	ATP binding site [chemical binding]; other site
290397000317	Mg2+ binding site [ion binding]; other site
290397000318	G-X-G motif; other site
290397000319	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397000320	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
290397000321	heme-binding residues [chemical binding]; other site
290397000322	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397000323	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290397000324	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
290397000325	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
290397000326	active site
290397000327	Zn binding site [ion binding]; other site
290397000328	rod shape-determining protein MreB; Provisional; Region: PRK13927
290397000329	MreB and similar proteins; Region: MreB_like; cd10225
290397000330	nucleotide binding site [chemical binding]; other site
290397000331	Mg binding site [ion binding]; other site
290397000332	putative protofilament interaction site [polypeptide binding]; other site
290397000333	RodZ interaction site [polypeptide binding]; other site
290397000334	rod shape-determining protein MreB; Provisional; Region: PRK13927
290397000335	MreB and similar proteins; Region: MreB_like; cd10225
290397000336	nucleotide binding site [chemical binding]; other site
290397000337	Mg binding site [ion binding]; other site
290397000338	putative protofilament interaction site [polypeptide binding]; other site
290397000339	RodZ interaction site [polypeptide binding]; other site
290397000340	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
290397000341	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397000342	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290397000343	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397000344	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397000345	active site
290397000346	ATP binding site [chemical binding]; other site
290397000347	substrate binding site [chemical binding]; other site
290397000348	activation loop (A-loop); other site
290397000349	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
290397000350	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
290397000351	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
290397000352	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
290397000353	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
290397000354	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
290397000355	putative active site [active]
290397000356	catalytic residue [active]
290397000357	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
290397000358	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
290397000359	5S rRNA interface [nucleotide binding]; other site
290397000360	CTC domain interface [polypeptide binding]; other site
290397000361	L16 interface [polypeptide binding]; other site
290397000362	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
290397000363	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
290397000364	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397000365	active site
290397000366	regulatory protein SpoVG; Reviewed; Region: PRK13259
290397000367	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
290397000368	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
290397000369	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
290397000370	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397000371	active site
290397000372	PilZ domain; Region: PilZ; pfam07238
290397000373	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
290397000374	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
290397000375	putative active site [active]
290397000376	catalytic site [active]
290397000377	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397000378	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397000379	phosphopeptide binding site; other site
290397000380	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397000381	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397000382	metal binding site [ion binding]; metal-binding site
290397000383	active site
290397000384	I-site; other site
290397000385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397000386	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397000387	putative substrate translocation pore; other site
290397000388	ADP-glucose phosphorylase; Region: PLN02643
290397000389	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
290397000390	nucleotide binding site/active site [active]
290397000391	HIT family signature motif; other site
290397000392	catalytic residue [active]
290397000393	glycogen synthase; Provisional; Region: glgA; PRK00654
290397000394	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
290397000395	ADP-binding pocket [chemical binding]; other site
290397000396	homodimer interface [polypeptide binding]; other site
290397000397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397000398	TPR repeat; Region: TPR_11; pfam13414
290397000399	binding surface
290397000400	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
290397000401	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
290397000402	hydroxyglutarate oxidase; Provisional; Region: PRK11728
290397000403	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
290397000404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397000405	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397000406	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
290397000407	active site
290397000408	DNA polymerase IV; Validated; Region: PRK02406
290397000409	DNA binding site [nucleotide binding]
290397000410	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397000411	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397000412	active site
290397000413	metal binding site [ion binding]; metal-binding site
290397000414	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
290397000415	Response regulator receiver domain; Region: Response_reg; pfam00072
290397000416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397000417	active site
290397000418	phosphorylation site [posttranslational modification]
290397000419	intermolecular recognition site; other site
290397000420	dimerization interface [polypeptide binding]; other site
290397000421	DHHA1 domain; Region: DHHA1; pfam02272
290397000422	HPr kinase/phosphorylase; Provisional; Region: PRK05428
290397000423	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
290397000424	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
290397000425	Hpr binding site; other site
290397000426	active site
290397000427	homohexamer subunit interaction site [polypeptide binding]; other site
290397000428	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
290397000429	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397000430	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
290397000431	active pocket/dimerization site; other site
290397000432	active site
290397000433	phosphorylation site [posttranslational modification]
290397000434	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
290397000435	active site
290397000436	phosphorylation site [posttranslational modification]
290397000437	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
290397000438	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
290397000439	dimerization domain swap beta strand [polypeptide binding]; other site
290397000440	regulatory protein interface [polypeptide binding]; other site
290397000441	active site
290397000442	regulatory phosphorylation site [posttranslational modification]; other site
290397000443	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
290397000444	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
290397000445	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290397000446	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290397000447	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
290397000448	S-adenosylmethionine synthetase; Validated; Region: PRK05250
290397000449	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
290397000450	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
290397000451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397000452	putative DNA binding site [nucleotide binding]; other site
290397000453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397000454	S-adenosylmethionine binding site [chemical binding]; other site
290397000455	Adenosylhomocysteinase; Provisional; Region: PTZ00075
290397000456	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
290397000457	homotetramer interface [polypeptide binding]; other site
290397000458	ligand binding site [chemical binding]; other site
290397000459	catalytic site [active]
290397000460	NAD binding site [chemical binding]; other site
290397000461	Bacitracin resistance protein BacA; Region: BacA; pfam02673
290397000462	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
290397000463	putative active site [active]
290397000464	putative CoA binding site [chemical binding]; other site
290397000465	nudix motif; other site
290397000466	metal binding site [ion binding]; metal-binding site
290397000467	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
290397000468	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
290397000469	Substrate binding site; other site
290397000470	Cupin domain; Region: Cupin_2; cl17218
290397000471	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
290397000472	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
290397000473	active site
290397000474	substrate binding site [chemical binding]; other site
290397000475	metal binding site [ion binding]; metal-binding site
290397000476	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
290397000477	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397000478	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397000479	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
290397000480	Domain of unknown function (DUF814); Region: DUF814; pfam05670
290397000481	SprT-like family; Region: SprT-like; pfam10263
290397000482	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397000483	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397000484	Family of unknown function (DUF490); Region: DUF490; pfam04357
290397000485	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290397000486	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
290397000487	hypothetical protein; Provisional; Region: PRK07338
290397000488	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
290397000489	metal binding site [ion binding]; metal-binding site
290397000490	dimer interface [polypeptide binding]; other site
290397000491	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
290397000492	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290397000493	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
290397000494	nucleotide binding site [chemical binding]; other site
290397000495	N-acetyl-L-glutamate binding site [chemical binding]; other site
290397000496	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
290397000497	Sulfatase; Region: Sulfatase; cl17466
290397000498	Sulfatase; Region: Sulfatase; cl17466
290397000499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397000500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000501	ATP binding site [chemical binding]; other site
290397000502	Mg2+ binding site [ion binding]; other site
290397000503	G-X-G motif; other site
290397000504	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
290397000505	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
290397000506	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
290397000507	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
290397000508	putative active site [active]
290397000509	dimerization interface [polypeptide binding]; other site
290397000510	putative tRNAtyr binding site [nucleotide binding]; other site
290397000511	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
290397000512	nucleotide binding site/active site [active]
290397000513	HIT family signature motif; other site
290397000514	catalytic residue [active]
290397000515	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
290397000516	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
290397000517	homotrimer interaction site [polypeptide binding]; other site
290397000518	active site
290397000519	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
290397000520	prephenate dehydrogenase; Validated; Region: PRK08507
290397000521	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
290397000522	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
290397000523	hinge; other site
290397000524	active site
290397000525	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
290397000526	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
290397000527	NAD(P) binding site [chemical binding]; other site
290397000528	shikimate binding site; other site
290397000529	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
290397000530	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
290397000531	Tetramer interface [polypeptide binding]; other site
290397000532	active site
290397000533	FMN-binding site [chemical binding]; other site
290397000534	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
290397000535	shikimate kinase; Reviewed; Region: aroK; PRK00131
290397000536	ADP binding site [chemical binding]; other site
290397000537	magnesium binding site [ion binding]; other site
290397000538	putative shikimate binding site; other site
290397000539	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
290397000540	active site
290397000541	dimer interface [polypeptide binding]; other site
290397000542	metal binding site [ion binding]; metal-binding site
290397000543	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
290397000544	Dehydroquinase class II; Region: DHquinase_II; pfam01220
290397000545	trimer interface [polypeptide binding]; other site
290397000546	active site
290397000547	dimer interface [polypeptide binding]; other site
290397000548	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290397000549	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290397000550	active site
290397000551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290397000552	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
290397000553	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
290397000554	heme binding site [chemical binding]; other site
290397000555	ferroxidase pore; other site
290397000556	ferroxidase diiron center [ion binding]; other site
290397000557	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
290397000558	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
290397000559	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397000560	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397000561	RNA binding surface [nucleotide binding]; other site
290397000562	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397000563	active site
290397000564	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
290397000565	CoA binding domain; Region: CoA_binding; cl17356
290397000566	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
290397000567	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
290397000568	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
290397000569	HflX GTPase family; Region: HflX; cd01878
290397000570	G1 box; other site
290397000571	GTP/Mg2+ binding site [chemical binding]; other site
290397000572	Switch I region; other site
290397000573	G2 box; other site
290397000574	G3 box; other site
290397000575	Switch II region; other site
290397000576	G4 box; other site
290397000577	G5 box; other site
290397000578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397000579	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
290397000580	active site
290397000581	catalytic site [active]
290397000582	substrate binding site [chemical binding]; other site
290397000583	Peptidase family M48; Region: Peptidase_M48; pfam01435
290397000584	gamma-glutamyl kinase; Provisional; Region: PRK05429
290397000585	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
290397000586	nucleotide binding site [chemical binding]; other site
290397000587	homotetrameric interface [polypeptide binding]; other site
290397000588	putative phosphate binding site [ion binding]; other site
290397000589	putative allosteric binding site; other site
290397000590	PUA domain; Region: PUA; cl00607
290397000591	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
290397000592	putative catalytic cysteine [active]
290397000593	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
290397000594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397000595	S-adenosylmethionine binding site [chemical binding]; other site
290397000596	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
290397000597	EamA-like transporter family; Region: EamA; pfam00892
290397000598	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397000599	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397000600	active site
290397000601	ATP binding site [chemical binding]; other site
290397000602	substrate binding site [chemical binding]; other site
290397000603	activation loop (A-loop); other site
290397000604	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
290397000605	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290397000606	dimer interface [polypeptide binding]; other site
290397000607	PYR/PP interface [polypeptide binding]; other site
290397000608	TPP binding site [chemical binding]; other site
290397000609	substrate binding site [chemical binding]; other site
290397000610	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290397000611	Domain of unknown function; Region: EKR; smart00890
290397000612	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290397000613	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
290397000614	TPP-binding site [chemical binding]; other site
290397000615	dimer interface [polypeptide binding]; other site
290397000616	Hemerythrin; Region: Hemerythrin; cd12107
290397000617	Fe binding site [ion binding]; other site
290397000618	Transposase IS200 like; Region: Y1_Tnp; cl00848
290397000619	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397000620	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
290397000621	putative NAD(P) binding site [chemical binding]; other site
290397000622	active site
290397000623	putative substrate binding site [chemical binding]; other site
290397000624	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
290397000625	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
290397000626	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290397000627	putative catalytic site [active]
290397000628	putative phosphate binding site [ion binding]; other site
290397000629	putative metal binding site [ion binding]; other site
290397000630	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397000631	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397000632	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397000633	DsrE/DsrF-like family; Region: DrsE; pfam02635
290397000634	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397000635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397000636	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
290397000637	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397000638	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397000639	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290397000640	DNA binding residues [nucleotide binding]
290397000641	Putative zinc-finger; Region: zf-HC2; pfam13490
290397000642	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
290397000643	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
290397000644	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
290397000645	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
290397000646	active site
290397000647	catalytic residues [active]
290397000648	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
290397000649	phosphoglyceromutase; Provisional; Region: PRK05434
290397000650	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
290397000651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397000652	TPR repeat; Region: TPR_11; pfam13414
290397000653	binding surface
290397000654	TPR motif; other site
290397000655	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
290397000656	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
290397000657	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
290397000658	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
290397000659	TfoX N-terminal domain; Region: TfoX_N; pfam04993
290397000660	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
290397000661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397000662	FeS/SAM binding site; other site
290397000663	OPT oligopeptide transporter protein; Region: OPT; cl14607
290397000664	putative oligopeptide transporter, OPT family; Region: TIGR00733
290397000665	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
290397000666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397000667	S-adenosylmethionine binding site [chemical binding]; other site
290397000668	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
290397000669	RNA methyltransferase, RsmE family; Region: TIGR00046
290397000670	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397000671	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
290397000672	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290397000673	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290397000674	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397000675	DNA-binding site [nucleotide binding]; DNA binding site
290397000676	RNA-binding motif; other site
290397000677	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
290397000678	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
290397000679	FMN binding site [chemical binding]; other site
290397000680	substrate binding site [chemical binding]; other site
290397000681	putative catalytic residue [active]
290397000682	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
290397000683	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290397000684	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397000685	putative acyl-acceptor binding pocket; other site
290397000686	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397000687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397000688	dimer interface [polypeptide binding]; other site
290397000689	phosphorylation site [posttranslational modification]
290397000690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000691	ATP binding site [chemical binding]; other site
290397000692	Mg2+ binding site [ion binding]; other site
290397000693	G-X-G motif; other site
290397000694	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
290397000695	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397000696	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397000697	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290397000698	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397000699	carboxyltransferase (CT) interaction site; other site
290397000700	biotinylation site [posttranslational modification]; other site
290397000701	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
290397000702	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397000703	HSP70 interaction site [polypeptide binding]; other site
290397000704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397000705	binding surface
290397000706	TPR motif; other site
290397000707	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
290397000708	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
290397000709	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397000710	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397000711	active site
290397000712	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290397000713	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
290397000714	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
290397000715	Gram-negative bacterial tonB protein; Region: TonB; cl10048
290397000716	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397000717	elongation factor Ts; Reviewed; Region: tsf; PRK12332
290397000718	UBA/TS-N domain; Region: UBA; pfam00627
290397000719	Elongation factor TS; Region: EF_TS; pfam00889
290397000720	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
290397000721	rRNA interaction site [nucleotide binding]; other site
290397000722	S8 interaction site; other site
290397000723	putative laminin-1 binding site; other site
290397000724	Competence protein CoiA-like family; Region: CoiA; cl11541
290397000725	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
290397000726	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
290397000727	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
290397000728	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
290397000729	DNA binding site [nucleotide binding]
290397000730	catalytic residue [active]
290397000731	H2TH interface [polypeptide binding]; other site
290397000732	putative catalytic residues [active]
290397000733	turnover-facilitating residue; other site
290397000734	intercalation triad [nucleotide binding]; other site
290397000735	8OG recognition residue [nucleotide binding]; other site
290397000736	putative reading head residues; other site
290397000737	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
290397000738	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
290397000739	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
290397000740	RNA/DNA hybrid binding site [nucleotide binding]; other site
290397000741	active site
290397000742	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
290397000743	active site
290397000744	NTP binding site [chemical binding]; other site
290397000745	metal binding triad [ion binding]; metal-binding site
290397000746	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
290397000747	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
290397000748	putative nucleotide binding site [chemical binding]; other site
290397000749	uridine monophosphate binding site [chemical binding]; other site
290397000750	homohexameric interface [polypeptide binding]; other site
290397000751	ribosome recycling factor; Reviewed; Region: frr; PRK00083
290397000752	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
290397000753	hinge region; other site
290397000754	NAD synthetase; Provisional; Region: PRK13981
290397000755	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
290397000756	multimer interface [polypeptide binding]; other site
290397000757	active site
290397000758	catalytic triad [active]
290397000759	protein interface 1 [polypeptide binding]; other site
290397000760	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
290397000761	homodimer interface [polypeptide binding]; other site
290397000762	NAD binding pocket [chemical binding]; other site
290397000763	ATP binding pocket [chemical binding]; other site
290397000764	Mg binding site [ion binding]; other site
290397000765	active-site loop [active]
290397000766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397000767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397000768	metal binding site [ion binding]; metal-binding site
290397000769	active site
290397000770	I-site; other site
290397000771	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397000772	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397000773	DNA binding residues [nucleotide binding]
290397000774	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
290397000775	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
290397000776	TPP-binding site [chemical binding]; other site
290397000777	dimer interface [polypeptide binding]; other site
290397000778	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290397000779	PYR/PP interface [polypeptide binding]; other site
290397000780	dimer interface [polypeptide binding]; other site
290397000781	TPP binding site [chemical binding]; other site
290397000782	Ycf46; Provisional; Region: ycf46; CHL00195
290397000783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000784	ATP binding site [chemical binding]; other site
290397000785	Walker A motif; other site
290397000786	Walker B motif; other site
290397000787	arginine finger; other site
290397000788	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
290397000789	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
290397000790	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
290397000791	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
290397000792	active site
290397000793	catalytic site [active]
290397000794	4-alpha-glucanotransferase; Provisional; Region: PRK14508
290397000795	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
290397000796	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
290397000797	active site
290397000798	HIGH motif; other site
290397000799	nucleotide binding site [chemical binding]; other site
290397000800	active site
290397000801	KMSKS motif; other site
290397000802	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
290397000803	active site
290397000804	dinuclear metal binding site [ion binding]; other site
290397000805	dimerization interface [polypeptide binding]; other site
290397000806	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
290397000807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397000808	dimer interface [polypeptide binding]; other site
290397000809	phosphorylation site [posttranslational modification]
290397000810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000811	ATP binding site [chemical binding]; other site
290397000812	Mg2+ binding site [ion binding]; other site
290397000813	G-X-G motif; other site
290397000814	Myogenic Basic domain; Region: Basic; cl11603
290397000815	Response regulator receiver domain; Region: Response_reg; pfam00072
290397000816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397000817	active site
290397000818	phosphorylation site [posttranslational modification]
290397000819	intermolecular recognition site; other site
290397000820	dimerization interface [polypeptide binding]; other site
290397000821	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397000822	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397000823	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397000824	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397000825	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397000826	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
290397000827	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
290397000828	FAD binding pocket [chemical binding]; other site
290397000829	FAD binding motif [chemical binding]; other site
290397000830	phosphate binding motif [ion binding]; other site
290397000831	beta-alpha-beta structure motif; other site
290397000832	NAD binding pocket [chemical binding]; other site
290397000833	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
290397000834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397000835	dimerization interface [polypeptide binding]; other site
290397000836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397000837	dimer interface [polypeptide binding]; other site
290397000838	phosphorylation site [posttranslational modification]
290397000839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397000840	ATP binding site [chemical binding]; other site
290397000841	Mg2+ binding site [ion binding]; other site
290397000842	G-X-G motif; other site
290397000843	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397000844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397000845	active site
290397000846	phosphorylation site [posttranslational modification]
290397000847	intermolecular recognition site; other site
290397000848	dimerization interface [polypeptide binding]; other site
290397000849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000850	ATP binding site [chemical binding]; other site
290397000851	Walker B motif; other site
290397000852	arginine finger; other site
290397000853	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397000854	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
290397000855	Ligand binding site; other site
290397000856	metal-binding site
290397000857	Uncharacterized conserved protein [Function unknown]; Region: COG3342
290397000858	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
290397000859	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
290397000860	Transposase IS200 like; Region: Y1_Tnp; cl00848
290397000861	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
290397000862	active site 1 [active]
290397000863	dimer interface [polypeptide binding]; other site
290397000864	hexamer interface [polypeptide binding]; other site
290397000865	active site 2 [active]
290397000866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397000867	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
290397000868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397000869	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
290397000870	dimerization interface [polypeptide binding]; other site
290397000871	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290397000872	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
290397000873	dimer interface [polypeptide binding]; other site
290397000874	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290397000875	catalytic triad [active]
290397000876	peroxidatic and resolving cysteines [active]
290397000877	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
290397000878	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
290397000879	AAA ATPase domain; Region: AAA_16; pfam13191
290397000880	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397000881	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397000882	DNA binding residues [nucleotide binding]
290397000883	dimerization interface [polypeptide binding]; other site
290397000884	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397000885	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397000886	DNA binding residues [nucleotide binding]
290397000887	dimerization interface [polypeptide binding]; other site
290397000888	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
290397000889	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
290397000890	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397000891	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
290397000892	Peptidase family M1; Region: Peptidase_M1; pfam01433
290397000893	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
290397000894	Zn binding site [ion binding]; other site
290397000895	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
290397000896	methionine sulfoxide reductase B; Provisional; Region: PRK00222
290397000897	SelR domain; Region: SelR; pfam01641
290397000898	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397000899	dimer interface [polypeptide binding]; other site
290397000900	putative CheW interface [polypeptide binding]; other site
290397000901	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
290397000902	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
290397000903	reductive dehalogenase; Region: RDH; TIGR02486
290397000904	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
290397000905	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
290397000906	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
290397000907	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
290397000908	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
290397000909	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290397000910	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
290397000911	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290397000912	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290397000913	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
290397000914	Activator of aromatic catabolism; Region: XylR_N; pfam06505
290397000915	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
290397000916	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290397000917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000918	Walker A motif; other site
290397000919	ATP binding site [chemical binding]; other site
290397000920	Walker B motif; other site
290397000921	arginine finger; other site
290397000922	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397000923	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
290397000924	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290397000925	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397000926	catalytic residues [active]
290397000927	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
290397000928	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
290397000929	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397000930	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397000931	dimerization interface [polypeptide binding]; other site
290397000932	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
290397000933	intracellular protease, PfpI family; Region: PfpI; TIGR01382
290397000934	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
290397000935	conserved cys residue [active]
290397000936	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397000937	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290397000938	catalytic site [active]
290397000939	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397000940	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397000941	non-specific DNA binding site [nucleotide binding]; other site
290397000942	salt bridge; other site
290397000943	sequence-specific DNA binding site [nucleotide binding]; other site
290397000944	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
290397000945	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397000946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397000947	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
290397000948	putative dimerization interface [polypeptide binding]; other site
290397000949	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397000950	Domain of unknown function (DUF4304); Region: DUF4304; pfam14137
290397000951	Propionate catabolism activator; Region: PrpR_N; pfam06506
290397000952	PAS domain; Region: PAS_10; pfam13596
290397000953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397000954	putative active site [active]
290397000955	heme pocket [chemical binding]; other site
290397000956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397000957	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397000958	Walker A motif; other site
290397000959	ATP binding site [chemical binding]; other site
290397000960	Walker B motif; other site
290397000961	arginine finger; other site
290397000962	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397000963	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
290397000964	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
290397000965	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
290397000966	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
290397000967	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397000968	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
290397000969	substrate binding site [chemical binding]; other site
290397000970	oxyanion hole (OAH) forming residues; other site
290397000971	trimer interface [polypeptide binding]; other site
290397000972	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
290397000973	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
290397000974	dimer interface [polypeptide binding]; other site
290397000975	active site
290397000976	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397000977	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397000978	active site
290397000979	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
290397000980	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
290397000981	Moco binding site; other site
290397000982	metal coordination site [ion binding]; other site
290397000983	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
290397000984	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
290397000985	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
290397000986	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
290397000987	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
290397000988	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
290397000989	hinge; other site
290397000990	active site
290397000991	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
290397000992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397000993	S-adenosylmethionine binding site [chemical binding]; other site
290397000994	peptide chain release factor 1; Validated; Region: prfA; PRK00591
290397000995	This domain is found in peptide chain release factors; Region: PCRF; smart00937
290397000996	RF-1 domain; Region: RF-1; pfam00472
290397000997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397000998	PAS domain; Region: PAS_9; pfam13426
290397000999	putative active site [active]
290397001000	heme pocket [chemical binding]; other site
290397001001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397001002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001003	ATP binding site [chemical binding]; other site
290397001004	Mg2+ binding site [ion binding]; other site
290397001005	G-X-G motif; other site
290397001006	Predicted transcriptional regulators [Transcription]; Region: COG1510
290397001007	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
290397001008	UbiA prenyltransferase family; Region: UbiA; pfam01040
290397001009	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397001010	active site
290397001011	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
290397001012	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
290397001013	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
290397001014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397001015	FeS/SAM binding site; other site
290397001016	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
290397001017	Flavoprotein; Region: Flavoprotein; pfam02441
290397001018	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
290397001019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397001020	S-adenosylmethionine binding site [chemical binding]; other site
290397001021	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
290397001022	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397001023	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397001024	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397001025	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
290397001026	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
290397001027	substrate binding pocket [chemical binding]; other site
290397001028	chain length determination region; other site
290397001029	substrate-Mg2+ binding site; other site
290397001030	catalytic residues [active]
290397001031	aspartate-rich region 1; other site
290397001032	active site lid residues [active]
290397001033	aspartate-rich region 2; other site
290397001034	large tegument protein UL36; Provisional; Region: PHA03247
290397001035	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
290397001036	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
290397001037	dimerization interface 3.5A [polypeptide binding]; other site
290397001038	active site
290397001039	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
290397001040	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290397001041	Hemerythrin; Region: Hemerythrin; cd12107
290397001042	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
290397001043	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
290397001044	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
290397001045	Clp amino terminal domain; Region: Clp_N; pfam02861
290397001046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001047	Walker A motif; other site
290397001048	ATP binding site [chemical binding]; other site
290397001049	Walker B motif; other site
290397001050	arginine finger; other site
290397001051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001052	Walker A motif; other site
290397001053	ATP binding site [chemical binding]; other site
290397001054	Walker B motif; other site
290397001055	arginine finger; other site
290397001056	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290397001057	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
290397001058	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397001059	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397001060	protein binding site [polypeptide binding]; other site
290397001061	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397001062	protein binding site [polypeptide binding]; other site
290397001063	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
290397001064	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
290397001065	malonyl-CoA binding site [chemical binding]; other site
290397001066	dimer interface [polypeptide binding]; other site
290397001067	active site
290397001068	product binding site; other site
290397001069	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
290397001070	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397001071	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
290397001072	acyl-activating enzyme (AAE) consensus motif; other site
290397001073	AMP binding site [chemical binding]; other site
290397001074	active site
290397001075	CoA binding site [chemical binding]; other site
290397001076	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
290397001077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
290397001078	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
290397001079	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
290397001080	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
290397001081	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
290397001082	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
290397001083	Zn binding site [ion binding]; other site
290397001084	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
290397001085	FAD binding pocket [chemical binding]; other site
290397001086	FAD binding motif [chemical binding]; other site
290397001087	phosphate binding motif [ion binding]; other site
290397001088	beta-alpha-beta structure motif; other site
290397001089	NAD(p) ribose binding residues [chemical binding]; other site
290397001090	NAD binding pocket [chemical binding]; other site
290397001091	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
290397001092	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
290397001093	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
290397001094	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
290397001095	ribonuclease Z; Region: RNase_Z; TIGR02651
290397001096	Pirin-related protein [General function prediction only]; Region: COG1741
290397001097	Pirin; Region: Pirin; pfam02678
290397001098	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
290397001099	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
290397001100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001101	Walker A/P-loop; other site
290397001102	ATP binding site [chemical binding]; other site
290397001103	Q-loop/lid; other site
290397001104	ABC transporter signature motif; other site
290397001105	Walker B; other site
290397001106	D-loop; other site
290397001107	H-loop/switch region; other site
290397001108	ParB-like nuclease domain; Region: ParB; smart00470
290397001109	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
290397001110	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
290397001111	dimer interface [polypeptide binding]; other site
290397001112	active site
290397001113	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
290397001114	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397001115	substrate binding site [chemical binding]; other site
290397001116	oxyanion hole (OAH) forming residues; other site
290397001117	trimer interface [polypeptide binding]; other site
290397001118	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
290397001119	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
290397001120	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397001121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001122	dimer interface [polypeptide binding]; other site
290397001123	phosphorylation site [posttranslational modification]
290397001124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001125	ATP binding site [chemical binding]; other site
290397001126	G-X-G motif; other site
290397001127	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290397001128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001129	active site
290397001130	phosphorylation site [posttranslational modification]
290397001131	intermolecular recognition site; other site
290397001132	dimerization interface [polypeptide binding]; other site
290397001133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397001134	DNA binding site [nucleotide binding]
290397001135	selenocysteine synthase; Provisional; Region: PRK04311
290397001136	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
290397001137	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397001138	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397001139	catalytic residue [active]
290397001140	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
290397001141	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
290397001142	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397001143	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
290397001144	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397001145	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
290397001146	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397001147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001148	active site
290397001149	phosphorylation site [posttranslational modification]
290397001150	intermolecular recognition site; other site
290397001151	dimerization interface [polypeptide binding]; other site
290397001152	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397001153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001154	active site
290397001155	phosphorylation site [posttranslational modification]
290397001156	intermolecular recognition site; other site
290397001157	dimerization interface [polypeptide binding]; other site
290397001158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001159	Walker A motif; other site
290397001160	ATP binding site [chemical binding]; other site
290397001161	Walker B motif; other site
290397001162	arginine finger; other site
290397001163	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397001164	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397001165	PAS domain; Region: PAS_9; pfam13426
290397001166	putative active site [active]
290397001167	heme pocket [chemical binding]; other site
290397001168	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397001169	GAF domain; Region: GAF; pfam01590
290397001170	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397001171	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397001172	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397001173	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397001174	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397001175	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397001176	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397001177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001178	dimer interface [polypeptide binding]; other site
290397001179	phosphorylation site [posttranslational modification]
290397001180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001181	ATP binding site [chemical binding]; other site
290397001182	G-X-G motif; other site
290397001183	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
290397001184	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
290397001185	G1 box; other site
290397001186	putative GEF interaction site [polypeptide binding]; other site
290397001187	GTP/Mg2+ binding site [chemical binding]; other site
290397001188	Switch I region; other site
290397001189	G2 box; other site
290397001190	G3 box; other site
290397001191	Switch II region; other site
290397001192	G4 box; other site
290397001193	G5 box; other site
290397001194	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
290397001195	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
290397001196	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
290397001197	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
290397001198	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397001199	active site
290397001200	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
290397001201	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
290397001202	dimerization interface [polypeptide binding]; other site
290397001203	domain crossover interface; other site
290397001204	redox-dependent activation switch; other site
290397001205	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
290397001206	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397001207	putative NAD(P) binding site [chemical binding]; other site
290397001208	active site
290397001209	putative substrate binding site [chemical binding]; other site
290397001210	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397001211	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
290397001212	putative acyl-acceptor binding pocket; other site
290397001213	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
290397001214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290397001215	binding surface
290397001216	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397001217	TPR motif; other site
290397001218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397001219	TPR motif; other site
290397001220	binding surface
290397001221	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
290397001222	MarR family; Region: MarR; pfam01047
290397001223	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290397001224	GAF domain; Region: GAF; cl17456
290397001225	GAF domain; Region: GAF; pfam01590
290397001226	GAF domain; Region: GAF_2; pfam13185
290397001227	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397001228	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397001229	phosphopeptide binding site; other site
290397001230	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397001231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397001232	metal binding site [ion binding]; metal-binding site
290397001233	active site
290397001234	I-site; other site
290397001235	Protein of unknown function DUF72; Region: DUF72; pfam01904
290397001236	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290397001237	putative catalytic site [active]
290397001238	putative metal binding site [ion binding]; other site
290397001239	putative phosphate binding site [ion binding]; other site
290397001240	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
290397001241	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290397001242	active site
290397001243	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
290397001244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001245	Walker A/P-loop; other site
290397001246	ATP binding site [chemical binding]; other site
290397001247	Q-loop/lid; other site
290397001248	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001249	Q-loop/lid; other site
290397001250	ABC transporter signature motif; other site
290397001251	Walker B; other site
290397001252	D-loop; other site
290397001253	H-loop/switch region; other site
290397001254	exonuclease subunit SbcD; Provisional; Region: PRK10966
290397001255	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397001256	active site
290397001257	metal binding site [ion binding]; metal-binding site
290397001258	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
290397001259	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290397001260	active site residue [active]
290397001261	Chromate transporter; Region: Chromate_transp; pfam02417
290397001262	Chromate transporter; Region: Chromate_transp; pfam02417
290397001263	NosL; Region: NosL; cl01769
290397001264	FtsX-like permease family; Region: FtsX; pfam02687
290397001265	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397001266	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397001267	Walker A/P-loop; other site
290397001268	ATP binding site [chemical binding]; other site
290397001269	Q-loop/lid; other site
290397001270	ABC transporter signature motif; other site
290397001271	Walker B; other site
290397001272	D-loop; other site
290397001273	H-loop/switch region; other site
290397001274	OsmC-like protein; Region: OsmC; pfam02566
290397001275	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
290397001276	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
290397001277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397001278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397001279	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
290397001280	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
290397001281	active site
290397001282	homotetramer interface [polypeptide binding]; other site
290397001283	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
290397001284	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
290397001285	dinuclear metal binding motif [ion binding]; other site
290397001286	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397001287	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397001288	active site
290397001289	catalytic tetrad [active]
290397001290	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290397001291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397001292	S-adenosylmethionine binding site [chemical binding]; other site
290397001293	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
290397001294	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
290397001295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001296	Walker A/P-loop; other site
290397001297	ATP binding site [chemical binding]; other site
290397001298	Q-loop/lid; other site
290397001299	ABC transporter signature motif; other site
290397001300	Walker B; other site
290397001301	D-loop; other site
290397001302	H-loop/switch region; other site
290397001303	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
290397001304	putative dimerization interface [polypeptide binding]; other site
290397001305	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
290397001306	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
290397001307	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
290397001308	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290397001309	substrate binding pocket [chemical binding]; other site
290397001310	membrane-bound complex binding site; other site
290397001311	hinge residues; other site
290397001312	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
290397001313	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290397001314	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
290397001315	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397001316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397001317	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290397001318	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
290397001319	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397001320	carboxyltransferase (CT) interaction site; other site
290397001321	biotinylation site [posttranslational modification]; other site
290397001322	RNA polymerase sigma factor; Provisional; Region: PRK11922
290397001323	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397001324	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397001325	DNA binding residues [nucleotide binding]
290397001326	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
290397001327	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290397001328	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
290397001329	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397001330	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290397001331	Soluble P-type ATPase [General function prediction only]; Region: COG4087
290397001332	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290397001333	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
290397001334	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
290397001335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397001336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397001337	homodimer interface [polypeptide binding]; other site
290397001338	catalytic residue [active]
290397001339	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397001340	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
290397001341	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
290397001342	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
290397001343	dimerization interface [polypeptide binding]; other site
290397001344	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
290397001345	ATP binding site [chemical binding]; other site
290397001346	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
290397001347	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
290397001348	HupF/HypC family; Region: HupF_HypC; pfam01455
290397001349	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
290397001350	Acylphosphatase; Region: Acylphosphatase; pfam00708
290397001351	HypF finger; Region: zf-HYPF; pfam07503
290397001352	HypF finger; Region: zf-HYPF; pfam07503
290397001353	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
290397001354	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
290397001355	nickel binding site [ion binding]; other site
290397001356	hydrogenase 2 large subunit; Provisional; Region: PRK10467
290397001357	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
290397001358	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
290397001359	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
290397001360	hydrogenase 2 small subunit; Provisional; Region: PRK10468
290397001361	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290397001362	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
290397001363	MarR family; Region: MarR_2; pfam12802
290397001364	Nudix hydrolase homolog; Region: PLN02791
290397001365	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290397001366	N-terminal plug; other site
290397001367	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
290397001368	ligand-binding site [chemical binding]; other site
290397001369	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
290397001370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397001371	TPR motif; other site
290397001372	binding surface
290397001373	TPR repeat; Region: TPR_11; pfam13414
290397001374	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
290397001375	MgtC family; Region: MgtC; pfam02308
290397001376	Predicted membrane protein [Function unknown]; Region: COG2119
290397001377	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290397001378	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290397001379	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
290397001380	YwiC-like protein; Region: YwiC; pfam14256
290397001381	Hemerythrin; Region: Hemerythrin; cd12107
290397001382	Fe binding site [ion binding]; other site
290397001383	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
290397001384	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290397001385	Walker A/P-loop; other site
290397001386	ATP binding site [chemical binding]; other site
290397001387	Q-loop/lid; other site
290397001388	ABC transporter signature motif; other site
290397001389	Walker B; other site
290397001390	D-loop; other site
290397001391	H-loop/switch region; other site
290397001392	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
290397001393	nickel responsive regulator; Provisional; Region: PRK04460
290397001394	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
290397001395	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
290397001396	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290397001397	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290397001398	substrate binding site [chemical binding]; other site
290397001399	ATP binding site [chemical binding]; other site
290397001400	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290397001401	TAP-like protein; Region: Abhydrolase_4; pfam08386
290397001402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001403	dimer interface [polypeptide binding]; other site
290397001404	phosphorylation site [posttranslational modification]
290397001405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397001406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001407	ATP binding site [chemical binding]; other site
290397001408	G-X-G motif; other site
290397001409	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397001410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001411	active site
290397001412	phosphorylation site [posttranslational modification]
290397001413	intermolecular recognition site; other site
290397001414	dimerization interface [polypeptide binding]; other site
290397001415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001416	Walker A motif; other site
290397001417	ATP binding site [chemical binding]; other site
290397001418	Walker B motif; other site
290397001419	arginine finger; other site
290397001420	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397001421	Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920
290397001422	putative active site [active]
290397001423	redox center [active]
290397001424	Thioredoxin; Region: Thioredoxin_4; pfam13462
290397001425	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397001426	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397001427	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397001428	putative active site [active]
290397001429	heme pocket [chemical binding]; other site
290397001430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001431	dimer interface [polypeptide binding]; other site
290397001432	phosphorylation site [posttranslational modification]
290397001433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001434	ATP binding site [chemical binding]; other site
290397001435	Mg2+ binding site [ion binding]; other site
290397001436	G-X-G motif; other site
290397001437	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397001438	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
290397001439	dimerization interface [polypeptide binding]; other site
290397001440	active site
290397001441	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
290397001442	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
290397001443	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
290397001444	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290397001445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
290397001446	phosphorylation site [posttranslational modification]
290397001447	intermolecular recognition site; other site
290397001448	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
290397001449	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
290397001450	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
290397001451	Protein export membrane protein; Region: SecD_SecF; cl14618
290397001452	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
290397001453	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397001454	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397001455	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397001456	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397001457	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
290397001458	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
290397001459	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290397001460	Ca binding site [ion binding]; other site
290397001461	active site
290397001462	catalytic site [active]
290397001463	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
290397001464	active site
290397001465	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
290397001466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
290397001467	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
290397001468	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397001469	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397001470	dimerization interface [polypeptide binding]; other site
290397001471	aspartate racemase; Region: asp_race; TIGR00035
290397001472	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
290397001473	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
290397001474	putative dimer interface [polypeptide binding]; other site
290397001475	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397001476	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
290397001477	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
290397001478	aspartate aminotransferase; Provisional; Region: PRK06836
290397001479	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397001480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397001481	homodimer interface [polypeptide binding]; other site
290397001482	catalytic residue [active]
290397001483	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290397001484	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290397001485	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
290397001486	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397001487	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001488	dimer interface [polypeptide binding]; other site
290397001489	phosphorylation site [posttranslational modification]
290397001490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001491	ATP binding site [chemical binding]; other site
290397001492	Mg2+ binding site [ion binding]; other site
290397001493	G-X-G motif; other site
290397001494	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290397001495	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
290397001496	Walker A/P-loop; other site
290397001497	ATP binding site [chemical binding]; other site
290397001498	Q-loop/lid; other site
290397001499	ABC transporter signature motif; other site
290397001500	Walker B; other site
290397001501	D-loop; other site
290397001502	H-loop/switch region; other site
290397001503	Predicted esterase [General function prediction only]; Region: COG0400
290397001504	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397001505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397001506	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
290397001507	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
290397001508	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397001509	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397001510	active site
290397001511	catalytic tetrad [active]
290397001512	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
290397001513	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
290397001514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
290397001515	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290397001516	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290397001517	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397001518	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397001519	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397001520	dimerization interface [polypeptide binding]; other site
290397001521	short chain dehydrogenase; Provisional; Region: PRK08303
290397001522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397001523	NAD(P) binding site [chemical binding]; other site
290397001524	active site
290397001525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397001526	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397001527	putative substrate translocation pore; other site
290397001528	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
290397001529	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
290397001530	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397001531	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397001532	DNA binding residues [nucleotide binding]
290397001533	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
290397001534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001535	Walker A/P-loop; other site
290397001536	ATP binding site [chemical binding]; other site
290397001537	Q-loop/lid; other site
290397001538	ABC transporter signature motif; other site
290397001539	Walker B; other site
290397001540	D-loop; other site
290397001541	H-loop/switch region; other site
290397001542	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001544	active site
290397001545	phosphorylation site [posttranslational modification]
290397001546	intermolecular recognition site; other site
290397001547	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
290397001548	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397001549	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290397001550	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290397001551	ATP binding site [chemical binding]; other site
290397001552	putative Mg++ binding site [ion binding]; other site
290397001553	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
290397001554	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
290397001555	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
290397001556	metal binding site [ion binding]; metal-binding site
290397001557	putative dimer interface [polypeptide binding]; other site
290397001558	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
290397001559	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397001560	active site
290397001561	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
290397001562	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290397001563	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290397001564	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001566	active site
290397001567	phosphorylation site [posttranslational modification]
290397001568	intermolecular recognition site; other site
290397001569	dimerization interface [polypeptide binding]; other site
290397001570	GAF domain; Region: GAF_3; pfam13492
290397001571	GAF domain; Region: GAF_2; pfam13185
290397001572	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397001573	metal binding site [ion binding]; metal-binding site
290397001574	active site
290397001575	I-site; other site
290397001576	Tellurium resistance protein; Region: Tellurium_res; pfam10138
290397001577	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001579	active site
290397001580	phosphorylation site [posttranslational modification]
290397001581	intermolecular recognition site; other site
290397001582	dimerization interface [polypeptide binding]; other site
290397001583	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397001584	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
290397001585	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397001586	KMSKS motif; other site
290397001587	Hemerythrin; Region: Hemerythrin; cd12107
290397001588	Fe binding site [ion binding]; other site
290397001589	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397001590	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397001591	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397001592	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397001593	dimerization interface [polypeptide binding]; other site
290397001594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001595	ATP binding site [chemical binding]; other site
290397001596	Mg2+ binding site [ion binding]; other site
290397001597	G-X-G motif; other site
290397001598	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
290397001599	WYL domain; Region: WYL; pfam13280
290397001600	WYL domain; Region: WYL; pfam13280
290397001601	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001603	active site
290397001604	phosphorylation site [posttranslational modification]
290397001605	intermolecular recognition site; other site
290397001606	dimerization interface [polypeptide binding]; other site
290397001607	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
290397001608	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
290397001609	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
290397001610	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397001611	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
290397001612	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
290397001613	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
290397001614	heterotetramer interface [polypeptide binding]; other site
290397001615	active site pocket [active]
290397001616	cleavage site
290397001617	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
290397001618	homohexameric interface [polypeptide binding]; other site
290397001619	feedback inhibition sensing region; other site
290397001620	nucleotide binding site [chemical binding]; other site
290397001621	N-acetyl-L-glutamate binding site [chemical binding]; other site
290397001622	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
290397001623	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290397001624	Bacterial Ig-like domain; Region: Big_5; pfam13205
290397001625	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
290397001626	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
290397001627	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397001628	DsbD alpha interface [polypeptide binding]; other site
290397001629	catalytic residues [active]
290397001630	cysteine desulfurase; Provisional; Region: PRK14012
290397001631	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
290397001632	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397001633	catalytic residue [active]
290397001634	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
290397001635	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
290397001636	trimerization site [polypeptide binding]; other site
290397001637	active site
290397001638	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
290397001639	DnaJ domain; Region: DnaJ; pfam00226
290397001640	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
290397001641	NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712
290397001642	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
290397001643	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
290397001644	nucleotide binding site [chemical binding]; other site
290397001645	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290397001646	SBD interface [polypeptide binding]; other site
290397001647	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290397001648	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290397001649	catalytic loop [active]
290397001650	iron binding site [ion binding]; other site
290397001651	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
290397001652	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397001653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001654	active site
290397001655	phosphorylation site [posttranslational modification]
290397001656	intermolecular recognition site; other site
290397001657	dimerization interface [polypeptide binding]; other site
290397001658	CheB methylesterase; Region: CheB_methylest; pfam01339
290397001659	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
290397001660	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290397001661	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397001662	S-adenosylmethionine binding site [chemical binding]; other site
290397001663	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
290397001664	putative CheA interaction surface; other site
290397001665	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397001666	putative binding surface; other site
290397001667	active site
290397001668	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
290397001669	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
290397001670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001671	ATP binding site [chemical binding]; other site
290397001672	Mg2+ binding site [ion binding]; other site
290397001673	G-X-G motif; other site
290397001674	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
290397001675	CheD chemotactic sensory transduction; Region: CheD; cl00810
290397001676	GAF domain; Region: GAF_3; pfam13492
290397001677	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001679	active site
290397001680	phosphorylation site [posttranslational modification]
290397001681	intermolecular recognition site; other site
290397001682	dimerization interface [polypeptide binding]; other site
290397001683	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397001684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001685	active site
290397001686	phosphorylation site [posttranslational modification]
290397001687	intermolecular recognition site; other site
290397001688	CheW-like domain; Region: CheW; pfam01584
290397001689	CheW-like domain; Region: CheW; pfam01584
290397001690	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397001691	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397001692	dimer interface [polypeptide binding]; other site
290397001693	putative CheW interface [polypeptide binding]; other site
290397001694	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397001695	putative binding surface; other site
290397001696	active site
290397001697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001698	ATP binding site [chemical binding]; other site
290397001699	Mg2+ binding site [ion binding]; other site
290397001700	G-X-G motif; other site
290397001701	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
290397001702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001703	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001704	active site
290397001705	phosphorylation site [posttranslational modification]
290397001706	intermolecular recognition site; other site
290397001707	dimerization interface [polypeptide binding]; other site
290397001708	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397001709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001710	active site
290397001711	phosphorylation site [posttranslational modification]
290397001712	intermolecular recognition site; other site
290397001713	dimerization interface [polypeptide binding]; other site
290397001714	CheB methylesterase; Region: CheB_methylest; pfam01339
290397001715	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
290397001716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397001717	S-adenosylmethionine binding site [chemical binding]; other site
290397001718	Response regulator receiver domain; Region: Response_reg; pfam00072
290397001719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001720	active site
290397001721	phosphorylation site [posttranslational modification]
290397001722	intermolecular recognition site; other site
290397001723	dimerization interface [polypeptide binding]; other site
290397001724	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
290397001725	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
290397001726	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
290397001727	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
290397001728	purine nucleoside phosphorylase; Provisional; Region: PRK08202
290397001729	PilZ domain; Region: PilZ; pfam07238
290397001730	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
290397001731	active site
290397001732	catalytic motif [active]
290397001733	Zn binding site [ion binding]; other site
290397001734	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
290397001735	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
290397001736	active site
290397001737	Riboflavin kinase; Region: Flavokinase; pfam01687
290397001738	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
290397001739	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397001740	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
290397001741	Walker A motif; other site
290397001742	ATP binding site [chemical binding]; other site
290397001743	Walker B motif; other site
290397001744	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
290397001745	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
290397001746	Walker A motif; other site
290397001747	ATP binding site [chemical binding]; other site
290397001748	Walker B motif; other site
290397001749	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
290397001750	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397001751	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397001752	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290397001753	PAS domain; Region: PAS; smart00091
290397001754	putative active site [active]
290397001755	heme pocket [chemical binding]; other site
290397001756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001757	dimer interface [polypeptide binding]; other site
290397001758	phosphorylation site [posttranslational modification]
290397001759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001760	ATP binding site [chemical binding]; other site
290397001761	Mg2+ binding site [ion binding]; other site
290397001762	G-X-G motif; other site
290397001763	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397001764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001765	active site
290397001766	phosphorylation site [posttranslational modification]
290397001767	intermolecular recognition site; other site
290397001768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001769	Walker A motif; other site
290397001770	ATP binding site [chemical binding]; other site
290397001771	Walker B motif; other site
290397001772	arginine finger; other site
290397001773	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397001774	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
290397001775	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
290397001776	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397001777	Walker A/P-loop; other site
290397001778	ATP binding site [chemical binding]; other site
290397001779	Q-loop/lid; other site
290397001780	ABC transporter signature motif; other site
290397001781	Walker B; other site
290397001782	D-loop; other site
290397001783	H-loop/switch region; other site
290397001784	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
290397001785	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
290397001786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397001787	dimer interface [polypeptide binding]; other site
290397001788	phosphorylation site [posttranslational modification]
290397001789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397001790	ATP binding site [chemical binding]; other site
290397001791	Mg2+ binding site [ion binding]; other site
290397001792	G-X-G motif; other site
290397001793	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397001794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001795	active site
290397001796	phosphorylation site [posttranslational modification]
290397001797	intermolecular recognition site; other site
290397001798	dimerization interface [polypeptide binding]; other site
290397001799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001800	Walker A motif; other site
290397001801	ATP binding site [chemical binding]; other site
290397001802	Walker B motif; other site
290397001803	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397001804	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397001805	non-specific DNA binding site [nucleotide binding]; other site
290397001806	salt bridge; other site
290397001807	sequence-specific DNA binding site [nucleotide binding]; other site
290397001808	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397001809	Competence protein A; Region: Competence_A; pfam11104
290397001810	nucleotide binding site [chemical binding]; other site
290397001811	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397001812	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
290397001813	Pilus assembly protein, PilO; Region: PilO; pfam04350
290397001814	Pilus assembly protein, PilP; Region: PilP; pfam04351
290397001815	AMIN domain; Region: AMIN; pfam11741
290397001816	AMIN domain; Region: AMIN; pfam11741
290397001817	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
290397001818	Secretin and TonB N terminus short domain; Region: STN; pfam07660
290397001819	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
290397001820	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
290397001821	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
290397001822	elongation factor P; Validated; Region: PRK00529
290397001823	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
290397001824	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
290397001825	RNA binding site [nucleotide binding]; other site
290397001826	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
290397001827	RNA binding site [nucleotide binding]; other site
290397001828	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
290397001829	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397001830	carboxyltransferase (CT) interaction site; other site
290397001831	biotinylation site [posttranslational modification]; other site
290397001832	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
290397001833	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397001834	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397001835	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290397001836	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397001837	binding surface
290397001838	TPR motif; other site
290397001839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397001840	binding surface
290397001841	TPR motif; other site
290397001842	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290397001843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397001844	binding surface
290397001845	TPR motif; other site
290397001846	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290397001847	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
290397001848	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397001849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
290397001850	Family of unknown function (DUF490); Region: DUF490; pfam04357
290397001851	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397001852	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397001853	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397001854	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290397001855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397001856	exopolyphosphatase; Region: exo_poly_only; TIGR03706
290397001857	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290397001858	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290397001859	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
290397001860	TolB amino-terminal domain; Region: TolB_N; pfam04052
290397001861	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397001862	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397001863	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397001864	TonB C terminal; Region: TonB_2; pfam13103
290397001865	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
290397001866	TolR protein; Region: tolR; TIGR02801
290397001867	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
290397001868	glutamate racemase; Provisional; Region: PRK00865
290397001869	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
290397001870	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397001871	Walker A/P-loop; other site
290397001872	ATP binding site [chemical binding]; other site
290397001873	Q-loop/lid; other site
290397001874	ABC transporter signature motif; other site
290397001875	Walker B; other site
290397001876	D-loop; other site
290397001877	H-loop/switch region; other site
290397001878	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
290397001879	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397001880	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290397001881	C-terminal peptidase (prc); Region: prc; TIGR00225
290397001882	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290397001883	protein binding site [polypeptide binding]; other site
290397001884	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290397001885	Catalytic dyad [active]
290397001886	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
290397001887	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290397001888	DXD motif; other site
290397001889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397001890	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
290397001891	Coenzyme A binding pocket [chemical binding]; other site
290397001892	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290397001893	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397001894	active site
290397001895	motif I; other site
290397001896	motif II; other site
290397001897	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
290397001898	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
290397001899	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290397001900	P loop; other site
290397001901	GTP binding site [chemical binding]; other site
290397001902	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290397001903	AAA domain; Region: AAA_23; pfam13476
290397001904	Walker A/P-loop; other site
290397001905	ATP binding site [chemical binding]; other site
290397001906	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290397001907	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
290397001908	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290397001909	Q-loop/lid; other site
290397001910	ABC transporter signature motif; other site
290397001911	Walker B; other site
290397001912	D-loop; other site
290397001913	H-loop/switch region; other site
290397001914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397001915	dimerization interface [polypeptide binding]; other site
290397001916	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397001917	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397001918	dimer interface [polypeptide binding]; other site
290397001919	putative CheW interface [polypeptide binding]; other site
290397001920	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
290397001921	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
290397001922	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
290397001923	type II secretion system protein J; Region: gspJ; TIGR01711
290397001924	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
290397001925	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
290397001926	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
290397001927	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
290397001928	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
290397001929	type II secretion system protein F; Region: GspF; TIGR02120
290397001930	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397001931	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397001932	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397001933	type II secretion system protein E; Region: type_II_gspE; TIGR02533
290397001934	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
290397001935	Walker A motif; other site
290397001936	ATP binding site [chemical binding]; other site
290397001937	Walker B motif; other site
290397001938	type II secretion system protein D; Region: type_II_gspD; TIGR02517
290397001939	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
290397001940	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
290397001941	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
290397001942	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
290397001943	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
290397001944	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397001945	protein binding site [polypeptide binding]; other site
290397001946	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397001947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397001948	active site
290397001949	phosphorylation site [posttranslational modification]
290397001950	intermolecular recognition site; other site
290397001951	dimerization interface [polypeptide binding]; other site
290397001952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397001953	Walker A motif; other site
290397001954	ATP binding site [chemical binding]; other site
290397001955	Walker B motif; other site
290397001956	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397001957	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
290397001958	transcription termination factor Rho; Provisional; Region: rho; PRK09376
290397001959	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
290397001960	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
290397001961	RNA binding site [nucleotide binding]; other site
290397001962	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
290397001963	multimer interface [polypeptide binding]; other site
290397001964	Walker A motif; other site
290397001965	ATP binding site [chemical binding]; other site
290397001966	Walker B motif; other site
290397001967	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
290397001968	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
290397001969	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
290397001970	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
290397001971	nucleotide binding pocket [chemical binding]; other site
290397001972	K-X-D-G motif; other site
290397001973	catalytic site [active]
290397001974	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
290397001975	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
290397001976	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
290397001977	DNA binding site [nucleotide binding]
290397001978	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
290397001979	Dimer interface [polypeptide binding]; other site
290397001980	acylphosphatase; Provisional; Region: PRK14441
290397001981	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
290397001982	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290397001983	B12 binding site [chemical binding]; other site
290397001984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397001985	FeS/SAM binding site; other site
290397001986	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
290397001987	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
290397001988	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
290397001989	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290397001990	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
290397001991	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
290397001992	Transcriptional regulator; Region: Rrf2; cl17282
290397001993	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290397001994	IHF dimer interface [polypeptide binding]; other site
290397001995	IHF - DNA interface [nucleotide binding]; other site
290397001996	FHIPEP family; Region: FHIPEP; pfam00771
290397001997	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
290397001998	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
290397001999	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
290397002000	FliP family; Region: FliP; cl00593
290397002001	type III secretion system protein YscR; Provisional; Region: PRK12797
290397002002	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
290397002003	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
290397002004	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
290397002005	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
290397002006	diiron binding motif [ion binding]; other site
290397002007	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
290397002008	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397002009	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397002010	DNA binding residues [nucleotide binding]
290397002011	dimerization interface [polypeptide binding]; other site
290397002012	histidinol dehydrogenase; Region: hisD; TIGR00069
290397002013	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
290397002014	NAD binding site [chemical binding]; other site
290397002015	dimerization interface [polypeptide binding]; other site
290397002016	product binding site; other site
290397002017	substrate binding site [chemical binding]; other site
290397002018	zinc binding site [ion binding]; other site
290397002019	catalytic residues [active]
290397002020	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
290397002021	putative active site pocket [active]
290397002022	4-fold oligomerization interface [polypeptide binding]; other site
290397002023	metal binding residues [ion binding]; metal-binding site
290397002024	3-fold/trimer interface [polypeptide binding]; other site
290397002025	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
290397002026	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
290397002027	putative active site [active]
290397002028	oxyanion strand; other site
290397002029	catalytic triad [active]
290397002030	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
290397002031	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
290397002032	catalytic residues [active]
290397002033	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
290397002034	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
290397002035	substrate binding site [chemical binding]; other site
290397002036	glutamase interaction surface [polypeptide binding]; other site
290397002037	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
290397002038	Yqey-like protein; Region: YqeY; pfam09424
290397002039	DNA primase, catalytic core; Region: dnaG; TIGR01391
290397002040	CHC2 zinc finger; Region: zf-CHC2; pfam01807
290397002041	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
290397002042	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
290397002043	active site
290397002044	metal binding site [ion binding]; metal-binding site
290397002045	interdomain interaction site; other site
290397002046	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
290397002047	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
290397002048	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290397002049	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
290397002050	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397002051	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
290397002052	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397002053	DNA binding residues [nucleotide binding]
290397002054	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
290397002055	Putative zinc ribbon domain; Region: DUF164; pfam02591
290397002056	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
290397002057	RNA/DNA hybrid binding site [nucleotide binding]; other site
290397002058	active site
290397002059	Predicted membrane protein [Function unknown]; Region: COG1584
290397002060	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
290397002061	active site
290397002062	catalytic residues [active]
290397002063	metal binding site [ion binding]; metal-binding site
290397002064	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397002065	HSP70 interaction site [polypeptide binding]; other site
290397002066	primosome assembly protein PriA; Validated; Region: PRK05580
290397002067	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397002068	ATP binding site [chemical binding]; other site
290397002069	putative Mg++ binding site [ion binding]; other site
290397002070	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
290397002071	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397002072	recombination factor protein RarA; Reviewed; Region: PRK13342
290397002073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002074	Walker A motif; other site
290397002075	ATP binding site [chemical binding]; other site
290397002076	Walker B motif; other site
290397002077	arginine finger; other site
290397002078	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
290397002079	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
290397002080	ATP-NAD kinase; Region: NAD_kinase; pfam01513
290397002081	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
290397002082	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290397002083	Walker A/P-loop; other site
290397002084	ATP binding site [chemical binding]; other site
290397002085	Q-loop/lid; other site
290397002086	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290397002087	ABC transporter signature motif; other site
290397002088	Walker B; other site
290397002089	D-loop; other site
290397002090	H-loop/switch region; other site
290397002091	Protein phosphatase 2C; Region: PP2C; pfam00481
290397002092	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
290397002093	active site
290397002094	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290397002095	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397002096	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
290397002097	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
290397002098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
290397002099	nucleotide binding region [chemical binding]; other site
290397002100	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
290397002101	SEC-C motif; Region: SEC-C; pfam02810
290397002102	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
290397002103	minor groove reading motif; other site
290397002104	helix-hairpin-helix signature motif; other site
290397002105	substrate binding pocket [chemical binding]; other site
290397002106	active site
290397002107	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
290397002108	AsnC family; Region: AsnC_trans_reg; pfam01037
290397002109	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290397002110	active site
290397002111	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
290397002112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397002113	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290397002114	DNA binding residues [nucleotide binding]
290397002115	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
290397002116	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397002117	active site
290397002118	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
290397002119	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
290397002120	putative NAD(P) binding site [chemical binding]; other site
290397002121	transcriptional regulator; Provisional; Region: PRK10632
290397002122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397002123	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
290397002124	putative effector binding pocket; other site
290397002125	dimerization interface [polypeptide binding]; other site
290397002126	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290397002127	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
290397002128	FAD binding pocket [chemical binding]; other site
290397002129	conserved FAD binding motif [chemical binding]; other site
290397002130	phosphate binding motif [ion binding]; other site
290397002131	beta-alpha-beta structure motif; other site
290397002132	NAD binding pocket [chemical binding]; other site
290397002133	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290397002134	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
290397002135	active site
290397002136	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
290397002137	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290397002138	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397002139	active site
290397002140	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397002141	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
290397002142	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290397002143	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397002144	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
290397002145	MarR family; Region: MarR; pfam01047
290397002146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397002147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397002148	dimer interface [polypeptide binding]; other site
290397002149	phosphorylation site [posttranslational modification]
290397002150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397002151	ATP binding site [chemical binding]; other site
290397002152	Mg2+ binding site [ion binding]; other site
290397002153	G-X-G motif; other site
290397002154	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
290397002155	substrate binding site [chemical binding]; other site
290397002156	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
290397002157	putative deacylase active site [active]
290397002158	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290397002159	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
290397002160	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290397002161	Predicted permeases [General function prediction only]; Region: RarD; COG2962
290397002162	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397002163	Ligand Binding Site [chemical binding]; other site
290397002164	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
290397002165	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
290397002166	putative active site [active]
290397002167	putative FMN binding site [chemical binding]; other site
290397002168	putative substrate binding site [chemical binding]; other site
290397002169	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290397002170	Ferritin-like domain; Region: Ferritin; pfam00210
290397002171	binuclear metal center [ion binding]; other site
290397002172	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
290397002173	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290397002174	Cysteine-rich domain; Region: CCG; pfam02754
290397002175	Cysteine-rich domain; Region: CCG; pfam02754
290397002176	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
290397002177	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
290397002178	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290397002179	active site
290397002180	catalytic site [active]
290397002181	substrate binding site [chemical binding]; other site
290397002182	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
290397002183	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
290397002184	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397002185	ligand binding site [chemical binding]; other site
290397002186	flexible hinge region; other site
290397002187	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
290397002188	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397002189	metal binding triad; other site
290397002190	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
290397002191	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290397002192	active site
290397002193	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
290397002194	Response regulator receiver domain; Region: Response_reg; pfam00072
290397002195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002196	active site
290397002197	phosphorylation site [posttranslational modification]
290397002198	intermolecular recognition site; other site
290397002199	dimerization interface [polypeptide binding]; other site
290397002200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397002201	NAD(P) binding site [chemical binding]; other site
290397002202	active site
290397002203	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
290397002204	Domain of unknown function DUF21; Region: DUF21; pfam01595
290397002205	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
290397002206	Transporter associated domain; Region: CorC_HlyC; smart01091
290397002207	hypothetical protein; Provisional; Region: PRK07877
290397002208	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
290397002209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397002210	S-adenosylmethionine binding site [chemical binding]; other site
290397002211	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
290397002212	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
290397002213	TPP-binding site [chemical binding]; other site
290397002214	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
290397002215	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
290397002216	E3 interaction surface; other site
290397002217	lipoyl attachment site [posttranslational modification]; other site
290397002218	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
290397002219	Protein of unknown function DUF72; Region: DUF72; pfam01904
290397002220	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
290397002221	active site
290397002222	DNA binding site [nucleotide binding]
290397002223	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
290397002224	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
290397002225	DNA binding site [nucleotide binding]
290397002226	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
290397002227	nucleotide binding site [chemical binding]; other site
290397002228	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
290397002229	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397002230	ATP binding site [chemical binding]; other site
290397002231	putative Mg++ binding site [ion binding]; other site
290397002232	nucleotide binding region [chemical binding]; other site
290397002233	helicase superfamily c-terminal domain; Region: HELICc; smart00490
290397002234	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
290397002235	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290397002236	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
290397002237	putative dimer interface [polypeptide binding]; other site
290397002238	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
290397002239	Clp amino terminal domain; Region: Clp_N; pfam02861
290397002240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002241	Walker A motif; other site
290397002242	ATP binding site [chemical binding]; other site
290397002243	Walker B motif; other site
290397002244	arginine finger; other site
290397002245	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002246	Walker A motif; other site
290397002247	ATP binding site [chemical binding]; other site
290397002248	Walker B motif; other site
290397002249	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290397002250	Uncharacterized conserved protein [Function unknown]; Region: COG2127
290397002251	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290397002252	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290397002253	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
290397002254	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290397002255	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397002256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397002257	DNA binding residues [nucleotide binding]
290397002258	Putative zinc-finger; Region: zf-HC2; pfam13490
290397002259	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
290397002260	heme-binding residues [chemical binding]; other site
290397002261	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397002262	molybdopterin cofactor binding site; other site
290397002263	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
290397002264	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
290397002265	4Fe-4S binding domain; Region: Fer4_2; pfam12797
290397002266	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290397002267	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290397002268	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
290397002269	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
290397002270	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
290397002271	Cu(I) binding site [ion binding]; other site
290397002272	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
290397002273	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
290397002274	Cytochrome c; Region: Cytochrom_C; pfam00034
290397002275	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
290397002276	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
290397002277	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
290397002278	Subunit I/III interface [polypeptide binding]; other site
290397002279	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
290397002280	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
290397002281	thiamine pyrophosphate protein; Provisional; Region: PRK08273
290397002282	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
290397002283	PYR/PP interface [polypeptide binding]; other site
290397002284	dimer interface [polypeptide binding]; other site
290397002285	tetramer interface [polypeptide binding]; other site
290397002286	TPP binding site [chemical binding]; other site
290397002287	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290397002288	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
290397002289	TPP-binding site [chemical binding]; other site
290397002290	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
290397002291	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
290397002292	putative active site pocket [active]
290397002293	putative metal binding site [ion binding]; other site
290397002294	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290397002295	FAD binding domain; Region: FAD_binding_4; pfam01565
290397002296	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290397002297	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
290397002298	putative ADP-ribose binding site [chemical binding]; other site
290397002299	putative active site [active]
290397002300	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397002301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002302	active site
290397002303	phosphorylation site [posttranslational modification]
290397002304	intermolecular recognition site; other site
290397002305	dimerization interface [polypeptide binding]; other site
290397002306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002307	Walker A motif; other site
290397002308	ATP binding site [chemical binding]; other site
290397002309	Walker B motif; other site
290397002310	arginine finger; other site
290397002311	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397002312	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290397002313	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
290397002314	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
290397002315	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
290397002316	active site
290397002317	DNA binding site [nucleotide binding]
290397002318	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
290397002319	DNA binding site [nucleotide binding]
290397002320	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
290397002321	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
290397002322	active site
290397002323	dimer interface [polypeptide binding]; other site
290397002324	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
290397002325	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
290397002326	active site
290397002327	FMN binding site [chemical binding]; other site
290397002328	substrate binding site [chemical binding]; other site
290397002329	3Fe-4S cluster binding site [ion binding]; other site
290397002330	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
290397002331	domain interface; other site
290397002332	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
290397002333	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397002334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397002335	putative substrate translocation pore; other site
290397002336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397002337	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
290397002338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397002339	FeS/SAM binding site; other site
290397002340	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
290397002341	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290397002342	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
290397002343	4Fe-4S binding domain; Region: Fer4; pfam00037
290397002344	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397002345	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397002346	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397002347	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
290397002348	molybdopterin cofactor binding site; other site
290397002349	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397002350	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
290397002351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290397002352	Walker A motif; other site
290397002353	ATP binding site [chemical binding]; other site
290397002354	Family description; Region: UvrD_C_2; pfam13538
290397002355	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
290397002356	dimer interface [polypeptide binding]; other site
290397002357	catalytic triad [active]
290397002358	peroxidatic and resolving cysteines [active]
290397002359	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
290397002360	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290397002361	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397002362	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397002363	ABC transporter; Region: ABC_tran_2; pfam12848
290397002364	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397002365	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397002366	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
290397002367	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
290397002368	Glutamate binding site [chemical binding]; other site
290397002369	NAD binding site [chemical binding]; other site
290397002370	catalytic residues [active]
290397002371	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397002372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002373	active site
290397002374	phosphorylation site [posttranslational modification]
290397002375	intermolecular recognition site; other site
290397002376	dimerization interface [polypeptide binding]; other site
290397002377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002378	Walker A motif; other site
290397002379	ATP binding site [chemical binding]; other site
290397002380	Walker B motif; other site
290397002381	arginine finger; other site
290397002382	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397002383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397002384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397002385	dimer interface [polypeptide binding]; other site
290397002386	phosphorylation site [posttranslational modification]
290397002387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397002388	ATP binding site [chemical binding]; other site
290397002389	Mg2+ binding site [ion binding]; other site
290397002390	G-X-G motif; other site
290397002391	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
290397002392	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397002393	Walker A/P-loop; other site
290397002394	ATP binding site [chemical binding]; other site
290397002395	Q-loop/lid; other site
290397002396	ABC transporter signature motif; other site
290397002397	Walker B; other site
290397002398	D-loop; other site
290397002399	H-loop/switch region; other site
290397002400	ABC-2 type transporter; Region: ABC2_membrane; cl17235
290397002401	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
290397002402	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290397002403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397002404	ATP binding site [chemical binding]; other site
290397002405	putative Mg++ binding site [ion binding]; other site
290397002406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397002407	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290397002408	nucleotide binding region [chemical binding]; other site
290397002409	ATP-binding site [chemical binding]; other site
290397002410	HRDC domain; Region: HRDC; pfam00570
290397002411	YaeQ protein; Region: YaeQ; cl01913
290397002412	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
290397002413	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397002414	dimerization interface [polypeptide binding]; other site
290397002415	putative Zn2+ binding site [ion binding]; other site
290397002416	putative DNA binding site [nucleotide binding]; other site
290397002417	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
290397002418	putative ABC transporter; Region: ycf24; CHL00085
290397002419	FeS assembly ATPase SufC; Region: sufC; TIGR01978
290397002420	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
290397002421	Walker A/P-loop; other site
290397002422	ATP binding site [chemical binding]; other site
290397002423	Q-loop/lid; other site
290397002424	ABC transporter signature motif; other site
290397002425	Walker B; other site
290397002426	D-loop; other site
290397002427	H-loop/switch region; other site
290397002428	FeS assembly protein SufD; Region: sufD; TIGR01981
290397002429	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
290397002430	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
290397002431	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
290397002432	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397002433	catalytic residue [active]
290397002434	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
290397002435	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
290397002436	trimerization site [polypeptide binding]; other site
290397002437	active site
290397002438	Domain of unknown function DUF59; Region: DUF59; cl00941
290397002439	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397002440	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397002441	phosphopeptide binding site; other site
290397002442	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397002443	Ligand Binding Site [chemical binding]; other site
290397002444	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
290397002445	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397002446	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397002447	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397002448	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397002449	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290397002450	protein binding site [polypeptide binding]; other site
290397002451	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290397002452	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290397002453	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397002454	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290397002455	FtsX-like permease family; Region: FtsX; pfam02687
290397002456	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397002457	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397002458	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397002459	protein binding site [polypeptide binding]; other site
290397002460	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397002461	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397002462	DNA binding residues [nucleotide binding]
290397002463	dimerization interface [polypeptide binding]; other site
290397002464	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
290397002465	Domain of unknown function (DUF222); Region: DUF222; pfam02720
290397002466	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397002467	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397002468	active site
290397002469	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
290397002470	putative rRNA binding site [nucleotide binding]; other site
290397002471	TfuA-like protein; Region: TfuA; pfam07812
290397002472	YcaO-like family; Region: YcaO; pfam02624
290397002473	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
290397002474	hypothetical protein; Provisional; Region: PRK07907
290397002475	active site
290397002476	metal binding site [ion binding]; metal-binding site
290397002477	dimer interface [polypeptide binding]; other site
290397002478	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
290397002479	homodimer interface [polypeptide binding]; other site
290397002480	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
290397002481	active site pocket [active]
290397002482	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
290397002483	active site
290397002484	DNA binding site [nucleotide binding]
290397002485	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
290397002486	Repair protein; Region: Repair_PSII; pfam04536
290397002487	Repair protein; Region: Repair_PSII; cl01535
290397002488	potassium/proton antiporter; Reviewed; Region: PRK05326
290397002489	TrkA-C domain; Region: TrkA_C; pfam02080
290397002490	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
290397002491	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397002492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397002493	non-specific DNA binding site [nucleotide binding]; other site
290397002494	salt bridge; other site
290397002495	sequence-specific DNA binding site [nucleotide binding]; other site
290397002496	Cupin domain; Region: Cupin_2; pfam07883
290397002497	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397002498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002499	active site
290397002500	phosphorylation site [posttranslational modification]
290397002501	intermolecular recognition site; other site
290397002502	dimerization interface [polypeptide binding]; other site
290397002503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
290397002504	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397002505	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
290397002506	active site
290397002507	Substrate binding site; other site
290397002508	Mg++ binding site; other site
290397002509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397002510	S-adenosylmethionine binding site [chemical binding]; other site
290397002511	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
290397002512	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290397002513	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397002514	ligand binding site [chemical binding]; other site
290397002515	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
290397002516	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
290397002517	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
290397002518	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
290397002519	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
290397002520	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
290397002521	nucleotide binding site [chemical binding]; other site
290397002522	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290397002523	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290397002524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397002525	TPR motif; other site
290397002526	binding surface
290397002527	TPR repeat; Region: TPR_11; pfam13414
290397002528	CAAX protease self-immunity; Region: Abi; cl00558
290397002529	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
290397002530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002531	active site
290397002532	phosphorylation site [posttranslational modification]
290397002533	intermolecular recognition site; other site
290397002534	dimerization interface [polypeptide binding]; other site
290397002535	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397002536	DNA binding site [nucleotide binding]
290397002537	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
290397002538	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
290397002539	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
290397002540	Ligand Binding Site [chemical binding]; other site
290397002541	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
290397002542	GAF domain; Region: GAF_3; pfam13492
290397002543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397002544	dimer interface [polypeptide binding]; other site
290397002545	phosphorylation site [posttranslational modification]
290397002546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397002547	ATP binding site [chemical binding]; other site
290397002548	Mg2+ binding site [ion binding]; other site
290397002549	G-X-G motif; other site
290397002550	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
290397002551	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
290397002552	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397002553	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
290397002554	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
290397002555	ligand binding site; other site
290397002556	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
290397002557	Protein of unknown function (DUF420); Region: DUF420; pfam04238
290397002558	ABC-2 type transporter; Region: ABC2_membrane; cl17235
290397002559	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
290397002560	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397002561	Walker A/P-loop; other site
290397002562	ATP binding site [chemical binding]; other site
290397002563	Q-loop/lid; other site
290397002564	ABC transporter signature motif; other site
290397002565	Walker B; other site
290397002566	D-loop; other site
290397002567	H-loop/switch region; other site
290397002568	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
290397002569	UbiA prenyltransferase family; Region: UbiA; pfam01040
290397002570	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
290397002571	TIGR02300 family protein; Region: FYDLN_acid
290397002572	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
290397002573	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
290397002574	Ligand Binding Site [chemical binding]; other site
290397002575	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
290397002576	intersubunit interface [polypeptide binding]; other site
290397002577	active site
290397002578	catalytic residue [active]
290397002579	phosphopentomutase; Provisional; Region: PRK05362
290397002580	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
290397002581	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
290397002582	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
290397002583	[4Fe-4S] binding site [ion binding]; other site
290397002584	molybdopterin cofactor binding site; other site
290397002585	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
290397002586	molybdopterin cofactor binding site; other site
290397002587	Cytochrome c552; Region: Cytochrom_C552; pfam02335
290397002588	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
290397002589	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
290397002590	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
290397002591	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
290397002592	Interdomain contacts; other site
290397002593	Cytokine receptor motif; other site
290397002594	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
290397002595	Interdomain contacts; other site
290397002596	Cytokine receptor motif; other site
290397002597	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
290397002598	hydrophobic ligand binding site; other site
290397002599	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
290397002600	anti sigma factor interaction site; other site
290397002601	regulatory phosphorylation site [posttranslational modification]; other site
290397002602	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
290397002603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
290397002604	ATP binding site [chemical binding]; other site
290397002605	Mg2+ binding site [ion binding]; other site
290397002606	G-X-G motif; other site
290397002607	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397002608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397002609	dimerization interface [polypeptide binding]; other site
290397002610	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
290397002611	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
290397002612	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
290397002613	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397002614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002615	active site
290397002616	phosphorylation site [posttranslational modification]
290397002617	intermolecular recognition site; other site
290397002618	dimerization interface [polypeptide binding]; other site
290397002619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002620	Walker A motif; other site
290397002621	ATP binding site [chemical binding]; other site
290397002622	Walker B motif; other site
290397002623	arginine finger; other site
290397002624	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397002625	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290397002626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397002627	dimer interface [polypeptide binding]; other site
290397002628	phosphorylation site [posttranslational modification]
290397002629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397002630	ATP binding site [chemical binding]; other site
290397002631	Mg2+ binding site [ion binding]; other site
290397002632	G-X-G motif; other site
290397002633	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
290397002634	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290397002635	homodimer interface [polypeptide binding]; other site
290397002636	substrate-cofactor binding pocket; other site
290397002637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397002638	catalytic residue [active]
290397002639	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290397002640	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397002641	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397002642	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290397002643	acyl-activating enzyme (AAE) consensus motif; other site
290397002644	acyl-activating enzyme (AAE) consensus motif; other site
290397002645	putative AMP binding site [chemical binding]; other site
290397002646	putative active site [active]
290397002647	putative CoA binding site [chemical binding]; other site
290397002648	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
290397002649	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290397002650	DTAP/Switch II; other site
290397002651	Switch I; other site
290397002652	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
290397002653	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
290397002654	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290397002655	DTAP/Switch II; other site
290397002656	Switch I; other site
290397002657	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290397002658	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397002659	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397002660	Magnesium ion binding site [ion binding]; other site
290397002661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397002662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397002663	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
290397002664	putative effector binding pocket; other site
290397002665	dimerization interface [polypeptide binding]; other site
290397002666	Uncharacterized conserved protein [Function unknown]; Region: COG2353
290397002667	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
290397002668	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
290397002669	putative active site [active]
290397002670	metal binding site [ion binding]; metal-binding site
290397002671	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
290397002672	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
290397002673	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
290397002674	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
290397002675	active site
290397002676	catalytic site [active]
290397002677	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
290397002678	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
290397002679	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
290397002680	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
290397002681	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397002682	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
290397002683	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
290397002684	tetramer interface [polypeptide binding]; other site
290397002685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397002686	catalytic residue [active]
290397002687	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
290397002688	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
290397002689	catalytic residues [active]
290397002690	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
290397002691	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
290397002692	active site
290397002693	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
290397002694	hypothetical protein; Reviewed; Region: PRK09588
290397002695	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
290397002696	multidrug efflux protein; Reviewed; Region: PRK01766
290397002697	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
290397002698	cation binding site [ion binding]; other site
290397002699	K+ potassium transporter; Region: K_trans; cl15781
290397002700	potassium uptake protein; Region: kup; TIGR00794
290397002701	Transmembrane secretion effector; Region: MFS_3; pfam05977
290397002702	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
290397002703	active site
290397002704	putative DNA-binding cleft [nucleotide binding]; other site
290397002705	dimer interface [polypeptide binding]; other site
290397002706	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
290397002707	RuvA N terminal domain; Region: RuvA_N; pfam01330
290397002708	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
290397002709	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
290397002710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002711	Walker A motif; other site
290397002712	ATP binding site [chemical binding]; other site
290397002713	Walker B motif; other site
290397002714	arginine finger; other site
290397002715	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
290397002716	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
290397002717	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
290397002718	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
290397002719	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
290397002720	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
290397002721	putative hydrophobic ligand binding site [chemical binding]; other site
290397002722	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
290397002723	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
290397002724	nucleotide binding site [chemical binding]; other site
290397002725	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
290397002726	putative DNA binding site [nucleotide binding]; other site
290397002727	putative homodimer interface [polypeptide binding]; other site
290397002728	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
290397002729	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
290397002730	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
290397002731	hypothetical protein; Provisional; Region: PRK10621
290397002732	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290397002733	Response regulator receiver domain; Region: Response_reg; pfam00072
290397002734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002735	active site
290397002736	phosphorylation site [posttranslational modification]
290397002737	intermolecular recognition site; other site
290397002738	dimerization interface [polypeptide binding]; other site
290397002739	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
290397002740	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
290397002741	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
290397002742	DNA binding site [nucleotide binding]
290397002743	active site
290397002744	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
290397002745	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
290397002746	AlkA N-terminal domain; Region: AlkA_N; pfam06029
290397002747	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
290397002748	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
290397002749	helix-hairpin-helix signature motif; other site
290397002750	Cupin domain; Region: Cupin_2; cl17218
290397002751	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
290397002752	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
290397002753	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
290397002754	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290397002755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002756	Walker A motif; other site
290397002757	ATP binding site [chemical binding]; other site
290397002758	Walker B motif; other site
290397002759	arginine finger; other site
290397002760	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397002761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397002762	putative substrate translocation pore; other site
290397002763	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397002764	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397002765	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397002766	dimerization interface [polypeptide binding]; other site
290397002767	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
290397002768	Alkaline phosphatase homologues; Region: alkPPc; smart00098
290397002769	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
290397002770	active site
290397002771	dimer interface [polypeptide binding]; other site
290397002772	Alkaline phosphatase homologues; Region: alkPPc; smart00098
290397002773	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
290397002774	active site
290397002775	dimer interface [polypeptide binding]; other site
290397002776	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290397002777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397002778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397002779	dimer interface [polypeptide binding]; other site
290397002780	phosphorylation site [posttranslational modification]
290397002781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397002782	ATP binding site [chemical binding]; other site
290397002783	Mg2+ binding site [ion binding]; other site
290397002784	G-X-G motif; other site
290397002785	Response regulator receiver domain; Region: Response_reg; pfam00072
290397002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002787	active site
290397002788	phosphorylation site [posttranslational modification]
290397002789	intermolecular recognition site; other site
290397002790	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
290397002791	Peptidase family M48; Region: Peptidase_M48; pfam01435
290397002792	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
290397002793	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397002794	DNA-binding site [nucleotide binding]; DNA binding site
290397002795	RNA-binding motif; other site
290397002796	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397002797	active site
290397002798	metal binding site [ion binding]; metal-binding site
290397002799	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290397002800	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
290397002801	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
290397002802	putative active site [active]
290397002803	catalytic site [active]
290397002804	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
290397002805	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
290397002806	putative active site [active]
290397002807	putative active site [active]
290397002808	catalytic site [active]
290397002809	catalytic site [active]
290397002810	Immunoglobulin I-set domain; Region: I-set; pfam07679
290397002811	Immunoglobulin domain; Region: Ig_2; pfam13895
290397002812	Immunoglobulin I-set domain; Region: I-set; pfam07679
290397002813	Immunoglobulin I-set domain; Region: I-set; pfam07679
290397002814	Immunoglobulin domain; Region: Ig; cl11960
290397002815	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
290397002816	homodimer interaction site [polypeptide binding]; other site
290397002817	cofactor binding site; other site
290397002818	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
290397002819	putative ligand binding site [chemical binding]; other site
290397002820	CoA binding domain; Region: CoA_binding_2; pfam13380
290397002821	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; pfam09965
290397002822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
290397002823	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
290397002824	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
290397002825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397002826	Walker A/P-loop; other site
290397002827	ATP binding site [chemical binding]; other site
290397002828	Q-loop/lid; other site
290397002829	ABC transporter signature motif; other site
290397002830	Walker B; other site
290397002831	D-loop; other site
290397002832	H-loop/switch region; other site
290397002833	TOBE domain; Region: TOBE; cl01440
290397002834	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
290397002835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397002836	putative PBP binding loops; other site
290397002837	dimer interface [polypeptide binding]; other site
290397002838	ABC-ATPase subunit interface; other site
290397002839	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290397002840	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
290397002841	Helix-turn-helix domain; Region: HTH_17; pfam12728
290397002842	PBP superfamily domain; Region: PBP_like; pfam12727
290397002843	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
290397002844	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
290397002845	putative ligand binding site [chemical binding]; other site
290397002846	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290397002847	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290397002848	TM-ABC transporter signature motif; other site
290397002849	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290397002850	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290397002851	TM-ABC transporter signature motif; other site
290397002852	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
290397002853	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
290397002854	Walker A/P-loop; other site
290397002855	ATP binding site [chemical binding]; other site
290397002856	Q-loop/lid; other site
290397002857	ABC transporter signature motif; other site
290397002858	Walker B; other site
290397002859	D-loop; other site
290397002860	H-loop/switch region; other site
290397002861	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
290397002862	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397002863	active site
290397002864	YCII-related domain; Region: YCII; cl00999
290397002865	RibD C-terminal domain; Region: RibD_C; cl17279
290397002866	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
290397002867	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397002868	active site
290397002869	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
290397002870	HTH domain; Region: HTH_11; pfam08279
290397002871	WYL domain; Region: WYL; pfam13280
290397002872	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
290397002873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397002874	NAD(P) binding site [chemical binding]; other site
290397002875	active site
290397002876	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
290397002877	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
290397002878	PYR/PP interface [polypeptide binding]; other site
290397002879	dimer interface [polypeptide binding]; other site
290397002880	TPP binding site [chemical binding]; other site
290397002881	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290397002882	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
290397002883	TPP-binding site; other site
290397002884	dimer interface [polypeptide binding]; other site
290397002885	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
290397002886	putative ADP-binding pocket [chemical binding]; other site
290397002887	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
290397002888	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
290397002889	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
290397002890	Outer membrane efflux protein; Region: OEP; pfam02321
290397002891	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397002892	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397002893	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
290397002894	Fatty acid desaturase; Region: FA_desaturase; pfam00487
290397002895	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
290397002896	putative di-iron ligands [ion binding]; other site
290397002897	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290397002898	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290397002899	active site
290397002900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
290397002901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397002902	Coenzyme A binding pocket [chemical binding]; other site
290397002903	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
290397002904	arsenical-resistance protein; Region: acr3; TIGR00832
290397002905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397002906	putative DNA binding site [nucleotide binding]; other site
290397002907	putative Zn2+ binding site [ion binding]; other site
290397002908	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397002909	catalytic residues [active]
290397002910	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
290397002911	Predicted permeases [General function prediction only]; Region: COG0701
290397002912	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
290397002913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397002914	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
290397002915	catalytic triad [active]
290397002916	Isochorismatase family; Region: Isochorismatase; pfam00857
290397002917	conserved cis-peptide bond; other site
290397002918	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
290397002919	MarR family; Region: MarR_2; pfam12802
290397002920	rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179
290397002921	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
290397002922	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
290397002923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397002924	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397002925	dimerization interface [polypeptide binding]; other site
290397002926	Transposase IS200 like; Region: Y1_Tnp; cl00848
290397002927	Isochorismatase family; Region: Isochorismatase; pfam00857
290397002928	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
290397002929	catalytic triad [active]
290397002930	dimer interface [polypeptide binding]; other site
290397002931	conserved cis-peptide bond; other site
290397002932	4Fe-4S binding domain; Region: Fer4; cl02805
290397002933	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290397002934	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
290397002935	FtsJ-like methyltransferase; Region: FtsJ; cl17430
290397002936	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
290397002937	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
290397002938	active site
290397002939	HIGH motif; other site
290397002940	dimer interface [polypeptide binding]; other site
290397002941	KMSKS motif; other site
290397002942	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
290397002943	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397002944	putative active site [active]
290397002945	metal binding site [ion binding]; metal-binding site
290397002946	homodimer binding site [polypeptide binding]; other site
290397002947	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
290397002948	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
290397002949	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397002950	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397002951	active site
290397002952	ATP binding site [chemical binding]; other site
290397002953	substrate binding site [chemical binding]; other site
290397002954	activation loop (A-loop); other site
290397002955	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
290397002956	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
290397002957	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397002958	catalytic residue [active]
290397002959	DHH family; Region: DHH; pfam01368
290397002960	endonuclease IV; Provisional; Region: PRK01060
290397002961	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
290397002962	AP (apurinic/apyrimidinic) site pocket; other site
290397002963	DNA interaction; other site
290397002964	Metal-binding active site; metal-binding site
290397002965	Fic/DOC family; Region: Fic; pfam02661
290397002966	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290397002967	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
290397002968	homodimer interface [polypeptide binding]; other site
290397002969	substrate-cofactor binding pocket; other site
290397002970	catalytic residue [active]
290397002971	Patatin-like phospholipase; Region: Patatin; pfam01734
290397002972	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397002973	metal binding triad; other site
290397002974	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
290397002975	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397002976	metal binding triad; other site
290397002977	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
290397002978	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397002979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397002980	active site
290397002981	phosphorylation site [posttranslational modification]
290397002982	intermolecular recognition site; other site
290397002983	dimerization interface [polypeptide binding]; other site
290397002984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397002985	Walker A motif; other site
290397002986	ATP binding site [chemical binding]; other site
290397002987	Walker B motif; other site
290397002988	arginine finger; other site
290397002989	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397002990	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
290397002991	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
290397002992	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
290397002993	active site
290397002994	catalytic site [active]
290397002995	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
290397002996	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
290397002997	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290397002998	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
290397002999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
290397003000	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397003001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
290397003002	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397003003	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397003004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003005	NAD(P) binding site [chemical binding]; other site
290397003006	active site
290397003007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003008	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397003009	NAD(P) binding site [chemical binding]; other site
290397003010	active site
290397003011	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
290397003012	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
290397003013	putative NAD(P) binding site [chemical binding]; other site
290397003014	catalytic Zn binding site [ion binding]; other site
290397003015	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
290397003016	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
290397003017	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
290397003018	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397003019	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397003020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
290397003021	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397003022	Domain of unknown function DUF20; Region: UPF0118; pfam01594
290397003023	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290397003024	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290397003025	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290397003026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397003027	Walker A/P-loop; other site
290397003028	ATP binding site [chemical binding]; other site
290397003029	Q-loop/lid; other site
290397003030	ABC transporter signature motif; other site
290397003031	Walker B; other site
290397003032	D-loop; other site
290397003033	H-loop/switch region; other site
290397003034	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290397003035	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
290397003036	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
290397003037	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290397003038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397003039	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397003040	DNA binding residues [nucleotide binding]
290397003041	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003042	malonic semialdehyde reductase; Provisional; Region: PRK10538
290397003043	NAD(P) binding site [chemical binding]; other site
290397003044	active site
290397003045	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397003046	dimerization interface [polypeptide binding]; other site
290397003047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003048	dimer interface [polypeptide binding]; other site
290397003049	phosphorylation site [posttranslational modification]
290397003050	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
290397003051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003052	ATP binding site [chemical binding]; other site
290397003053	Mg2+ binding site [ion binding]; other site
290397003054	G-X-G motif; other site
290397003055	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003056	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397003057	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
290397003058	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397003059	active site
290397003060	ATP binding site [chemical binding]; other site
290397003061	substrate binding site [chemical binding]; other site
290397003062	activation loop (A-loop); other site
290397003063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
290397003064	Uncharacterized conserved protein [Function unknown]; Region: COG1543
290397003065	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
290397003066	active site
290397003067	substrate binding site [chemical binding]; other site
290397003068	catalytic site [active]
290397003069	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
290397003070	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
290397003071	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
290397003072	dimer interface [polypeptide binding]; other site
290397003073	putative anticodon binding site; other site
290397003074	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
290397003075	motif 1; other site
290397003076	active site
290397003077	motif 2; other site
290397003078	motif 3; other site
290397003079	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290397003080	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397003081	FtsX-like permease family; Region: FtsX; pfam02687
290397003082	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
290397003083	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
290397003084	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003085	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003086	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003087	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003088	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290397003089	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397003090	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
290397003091	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
290397003092	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
290397003093	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
290397003094	trimer interface [polypeptide binding]; other site
290397003095	active site
290397003096	UDP-GlcNAc binding site [chemical binding]; other site
290397003097	lipid binding site [chemical binding]; lipid-binding site
290397003098	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
290397003099	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
290397003100	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
290397003101	active site
290397003102	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
290397003103	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
290397003104	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
290397003105	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
290397003106	substrate binding site [chemical binding]; other site
290397003107	active site
290397003108	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
290397003109	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397003110	FeS/SAM binding site; other site
290397003111	HemN C-terminal domain; Region: HemN_C; pfam06969
290397003112	ferrochelatase; Reviewed; Region: hemH; PRK00035
290397003113	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
290397003114	C-terminal domain interface [polypeptide binding]; other site
290397003115	active site
290397003116	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
290397003117	active site
290397003118	N-terminal domain interface [polypeptide binding]; other site
290397003119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397003120	HSP70 interaction site [polypeptide binding]; other site
290397003121	TPR repeat; Region: TPR_11; pfam13414
290397003122	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
290397003123	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
290397003124	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
290397003125	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
290397003126	generic binding surface II; other site
290397003127	generic binding surface I; other site
290397003128	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
290397003129	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003131	active site
290397003132	phosphorylation site [posttranslational modification]
290397003133	intermolecular recognition site; other site
290397003134	dimerization interface [polypeptide binding]; other site
290397003135	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
290397003136	substrate binding pocket [chemical binding]; other site
290397003137	aspartate-rich region 1; other site
290397003138	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
290397003139	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
290397003140	TPP-binding site; other site
290397003141	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290397003142	PYR/PP interface [polypeptide binding]; other site
290397003143	dimer interface [polypeptide binding]; other site
290397003144	TPP binding site [chemical binding]; other site
290397003145	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290397003146	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
290397003147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397003148	RNA binding surface [nucleotide binding]; other site
290397003149	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
290397003150	ribosome maturation protein RimP; Reviewed; Region: PRK00092
290397003151	Sm and related proteins; Region: Sm_like; cl00259
290397003152	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
290397003153	putative oligomer interface [polypeptide binding]; other site
290397003154	putative RNA binding site [nucleotide binding]; other site
290397003155	NusA N-terminal domain; Region: NusA_N; pfam08529
290397003156	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
290397003157	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
290397003158	RNA binding site [nucleotide binding]; other site
290397003159	homodimer interface [polypeptide binding]; other site
290397003160	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
290397003161	G-X-X-G motif; other site
290397003162	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
290397003163	G-X-X-G motif; other site
290397003164	Protein of unknown function (DUF448); Region: DUF448; pfam04296
290397003165	putative RNA binding cleft [nucleotide binding]; other site
290397003166	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
290397003167	translation initiation factor IF-2; Region: IF-2; TIGR00487
290397003168	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
290397003169	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
290397003170	G1 box; other site
290397003171	putative GEF interaction site [polypeptide binding]; other site
290397003172	GTP/Mg2+ binding site [chemical binding]; other site
290397003173	Switch I region; other site
290397003174	G2 box; other site
290397003175	G3 box; other site
290397003176	Switch II region; other site
290397003177	G4 box; other site
290397003178	G5 box; other site
290397003179	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
290397003180	Translation-initiation factor 2; Region: IF-2; pfam11987
290397003181	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
290397003182	Protein of unknown function (DUF503); Region: DUF503; pfam04456
290397003183	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
290397003184	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
290397003185	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
290397003186	RNA binding site [nucleotide binding]; other site
290397003187	active site
290397003188	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
290397003189	16S/18S rRNA binding site [nucleotide binding]; other site
290397003190	S13e-L30e interaction site [polypeptide binding]; other site
290397003191	25S rRNA binding site [nucleotide binding]; other site
290397003192	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
290397003193	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
290397003194	RNase E interface [polypeptide binding]; other site
290397003195	trimer interface [polypeptide binding]; other site
290397003196	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
290397003197	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
290397003198	RNase E interface [polypeptide binding]; other site
290397003199	trimer interface [polypeptide binding]; other site
290397003200	active site
290397003201	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
290397003202	putative nucleic acid binding region [nucleotide binding]; other site
290397003203	G-X-X-G motif; other site
290397003204	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
290397003205	RNA binding site [nucleotide binding]; other site
290397003206	domain interface; other site
290397003207	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
290397003208	trimer interface [polypeptide binding]; other site
290397003209	active site
290397003210	adenylosuccinate lyase; Provisional; Region: PRK07492
290397003211	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
290397003212	tetramer interface [polypeptide binding]; other site
290397003213	active site
290397003214	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397003215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397003216	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003217	dimer interface [polypeptide binding]; other site
290397003218	phosphorylation site [posttranslational modification]
290397003219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003220	ATP binding site [chemical binding]; other site
290397003221	Mg2+ binding site [ion binding]; other site
290397003222	G-X-G motif; other site
290397003223	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
290397003224	ATP binding site [chemical binding]; other site
290397003225	active site
290397003226	substrate binding site [chemical binding]; other site
290397003227	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
290397003228	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290397003229	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397003230	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397003231	protein binding site [polypeptide binding]; other site
290397003232	phosphoglycolate phosphatase; Provisional; Region: PRK13222
290397003233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397003234	active site
290397003235	motif I; other site
290397003236	motif II; other site
290397003237	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397003238	dimerization interface [polypeptide binding]; other site
290397003239	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397003240	Zn2+ binding site [ion binding]; other site
290397003241	Mg2+ binding site [ion binding]; other site
290397003242	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003244	active site
290397003245	phosphorylation site [posttranslational modification]
290397003246	intermolecular recognition site; other site
290397003247	dimerization interface [polypeptide binding]; other site
290397003248	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
290397003249	MoaE interaction surface [polypeptide binding]; other site
290397003250	MoeB interaction surface [polypeptide binding]; other site
290397003251	thiocarboxylated glycine; other site
290397003252	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
290397003253	MoaE homodimer interface [polypeptide binding]; other site
290397003254	MoaD interaction [polypeptide binding]; other site
290397003255	active site residues [active]
290397003256	RIP metalloprotease RseP; Region: TIGR00054
290397003257	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290397003258	active site
290397003259	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290397003260	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290397003261	putative substrate binding region [chemical binding]; other site
290397003262	AMMECR1; Region: AMMECR1; pfam01871
290397003263	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
290397003264	nudix motif; other site
290397003265	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
290397003266	active site clefts [active]
290397003267	zinc binding site [ion binding]; other site
290397003268	dimer interface [polypeptide binding]; other site
290397003269	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
290397003270	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290397003271	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290397003272	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
290397003273	EamA-like transporter family; Region: EamA; pfam00892
290397003274	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
290397003275	EamA-like transporter family; Region: EamA; pfam00892
290397003276	PAS fold; Region: PAS_4; pfam08448
290397003277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290397003278	putative active site [active]
290397003279	heme pocket [chemical binding]; other site
290397003280	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397003281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290397003282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
290397003283	dimer interface [polypeptide binding]; other site
290397003284	phosphorylation site [posttranslational modification]
290397003285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003286	ATP binding site [chemical binding]; other site
290397003287	Mg2+ binding site [ion binding]; other site
290397003288	G-X-G motif; other site
290397003289	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
290397003290	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397003291	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397003292	active site
290397003293	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
290397003294	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397003295	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397003296	active site
290397003297	ATP binding site [chemical binding]; other site
290397003298	substrate binding site [chemical binding]; other site
290397003299	activation loop (A-loop); other site
290397003300	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
290397003301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003302	active site
290397003303	phosphorylation site [posttranslational modification]
290397003304	intermolecular recognition site; other site
290397003305	dimerization interface [polypeptide binding]; other site
290397003306	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397003307	Zn2+ binding site [ion binding]; other site
290397003308	Mg2+ binding site [ion binding]; other site
290397003309	transcription termination factor Rho; Provisional; Region: PRK12608
290397003310	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290397003311	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397003312	Walker A motif; other site
290397003313	ATP binding site [chemical binding]; other site
290397003314	Walker B motif; other site
290397003315	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
290397003316	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
290397003317	oligomer interface [polypeptide binding]; other site
290397003318	tandem repeat interface [polypeptide binding]; other site
290397003319	active site residues [active]
290397003320	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
290397003321	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
290397003322	tandem repeat interface [polypeptide binding]; other site
290397003323	oligomer interface [polypeptide binding]; other site
290397003324	active site residues [active]
290397003325	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
290397003326	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290397003327	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
290397003328	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
290397003329	active site
290397003330	Zn binding site [ion binding]; other site
290397003331	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397003332	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397003333	phosphopeptide binding site; other site
290397003334	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
290397003335	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
290397003336	NAD(P) binding site [chemical binding]; other site
290397003337	catalytic residues [active]
290397003338	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
290397003339	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397003340	putative active site [active]
290397003341	putative metal binding site [ion binding]; other site
290397003342	Uncharacterized conserved protein [Function unknown]; Region: COG3342
290397003343	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
290397003344	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
290397003345	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290397003346	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
290397003347	dimer interface [polypeptide binding]; other site
290397003348	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290397003349	catalytic triad [active]
290397003350	peroxidatic and resolving cysteines [active]
290397003351	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397003352	non-specific DNA binding site [nucleotide binding]; other site
290397003353	salt bridge; other site
290397003354	sequence-specific DNA binding site [nucleotide binding]; other site
290397003355	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397003356	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290397003357	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355
290397003358	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397003359	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
290397003360	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
290397003361	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
290397003362	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
290397003363	G1 box; other site
290397003364	GTP/Mg2+ binding site [chemical binding]; other site
290397003365	G2 box; other site
290397003366	Switch I region; other site
290397003367	G3 box; other site
290397003368	Switch II region; other site
290397003369	G4 box; other site
290397003370	G5 box; other site
290397003371	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
290397003372	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
290397003373	heterotetramer interface [polypeptide binding]; other site
290397003374	active site pocket [active]
290397003375	cleavage site
290397003376	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397003377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397003378	S-adenosylmethionine binding site [chemical binding]; other site
290397003379	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397003380	dimerization interface [polypeptide binding]; other site
290397003381	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397003382	dimer interface [polypeptide binding]; other site
290397003383	putative CheW interface [polypeptide binding]; other site
290397003384	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
290397003385	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
290397003386	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
290397003387	putative NAD(P) binding site [chemical binding]; other site
290397003388	putative substrate binding site [chemical binding]; other site
290397003389	catalytic Zn binding site [ion binding]; other site
290397003390	structural Zn binding site [ion binding]; other site
290397003391	dimer interface [polypeptide binding]; other site
290397003392	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290397003393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003394	NAD(P) binding site [chemical binding]; other site
290397003395	active site
290397003396	Male sterility protein; Region: NAD_binding_4; pfam07993
290397003397	NAD(P) binding site [chemical binding]; other site
290397003398	active site
290397003399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003400	active site
290397003401	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
290397003402	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
290397003403	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397003404	acyl-activating enzyme (AAE) consensus motif; other site
290397003405	AMP binding site [chemical binding]; other site
290397003406	active site
290397003407	CoA binding site [chemical binding]; other site
290397003408	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397003409	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290397003410	putative acyl-acceptor binding pocket; other site
290397003411	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
290397003412	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
290397003413	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290397003414	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397003415	motif II; other site
290397003416	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397003417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003418	NAD(P) binding site [chemical binding]; other site
290397003419	active site
290397003420	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
290397003421	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
290397003422	putative [4Fe-4S] binding site [ion binding]; other site
290397003423	putative molybdopterin cofactor binding site [chemical binding]; other site
290397003424	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
290397003425	putative molybdopterin cofactor binding site; other site
290397003426	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
290397003427	Low-spin heme binding site [chemical binding]; other site
290397003428	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
290397003429	D-pathway; other site
290397003430	Putative water exit pathway; other site
290397003431	Binuclear center (active site) [active]
290397003432	K-pathway; other site
290397003433	Putative proton exit pathway; other site
290397003434	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
290397003435	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
290397003436	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
290397003437	4Fe-4S binding domain; Region: Fer4_5; pfam12801
290397003438	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
290397003439	4Fe-4S binding domain; Region: Fer4; cl02805
290397003440	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
290397003441	FixH; Region: FixH; pfam05751
290397003442	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
290397003443	YtkA-like; Region: YtkA; pfam13115
290397003444	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
290397003445	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
290397003446	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
290397003447	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
290397003448	metal-binding site [ion binding]
290397003449	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397003450	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
290397003451	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
290397003452	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
290397003453	substrate binding site [chemical binding]; other site
290397003454	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
290397003455	substrate binding site [chemical binding]; other site
290397003456	ligand binding site [chemical binding]; other site
290397003457	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
290397003458	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
290397003459	Fe-S cluster binding site [ion binding]; other site
290397003460	active site
290397003461	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
290397003462	nudix motif; other site
290397003463	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397003464	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397003465	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397003466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397003467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397003468	Outer membrane efflux protein; Region: OEP; pfam02321
290397003469	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
290397003470	ABC-2 type transporter; Region: ABC2_membrane; cl17235
290397003471	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
290397003472	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
290397003473	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397003474	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397003475	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397003476	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397003477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003478	dimer interface [polypeptide binding]; other site
290397003479	phosphorylation site [posttranslational modification]
290397003480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003481	ATP binding site [chemical binding]; other site
290397003482	Mg2+ binding site [ion binding]; other site
290397003483	G-X-G motif; other site
290397003484	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397003485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003486	active site
290397003487	phosphorylation site [posttranslational modification]
290397003488	intermolecular recognition site; other site
290397003489	CheB methylesterase; Region: CheB_methylest; pfam01339
290397003490	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
290397003491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003492	ATP binding site [chemical binding]; other site
290397003493	Mg2+ binding site [ion binding]; other site
290397003494	G-X-G motif; other site
290397003495	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003497	active site
290397003498	phosphorylation site [posttranslational modification]
290397003499	intermolecular recognition site; other site
290397003500	dimerization interface [polypeptide binding]; other site
290397003501	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397003502	dimer interface [polypeptide binding]; other site
290397003503	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
290397003504	putative CheW interface [polypeptide binding]; other site
290397003505	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
290397003506	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290397003507	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397003508	V-type ATP synthase subunit I; Validated; Region: PRK05771
290397003509	V-type ATP synthase subunit I; Validated; Region: PRK05771
290397003510	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
290397003511	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397003512	V-type ATP synthase subunit A; Provisional; Region: PRK04192
290397003513	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
290397003514	Walker A motif/ATP binding site; other site
290397003515	Walker B motif; other site
290397003516	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290397003517	V-type ATP synthase subunit B; Provisional; Region: PRK04196
290397003518	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290397003519	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
290397003520	Walker A motif homologous position; other site
290397003521	Walker B motif; other site
290397003522	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290397003523	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
290397003524	PAS domain S-box; Region: sensory_box; TIGR00229
290397003525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397003526	putative active site [active]
290397003527	heme pocket [chemical binding]; other site
290397003528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397003529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003530	dimer interface [polypeptide binding]; other site
290397003531	phosphorylation site [posttranslational modification]
290397003532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003533	ATP binding site [chemical binding]; other site
290397003534	Mg2+ binding site [ion binding]; other site
290397003535	G-X-G motif; other site
290397003536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397003537	short chain dehydrogenase; Provisional; Region: PRK07454
290397003538	NAD(P) binding site [chemical binding]; other site
290397003539	active site
290397003540	Immunoglobulin I-set domain; Region: I-set; pfam07679
290397003541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397003542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397003543	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397003544	binding surface
290397003545	TPR motif; other site
290397003546	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
290397003547	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397003548	dimerization interface [polypeptide binding]; other site
290397003549	putative DNA binding site [nucleotide binding]; other site
290397003550	putative Zn2+ binding site [ion binding]; other site
290397003551	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
290397003552	putative hydrophobic ligand binding site [chemical binding]; other site
290397003553	Domain of unknown function (DU1801); Region: DUF1801; cl17490
290397003554	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
290397003555	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
290397003556	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
290397003557	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
290397003558	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
290397003559	dimer interface [polypeptide binding]; other site
290397003560	[2Fe-2S] cluster binding site [ion binding]; other site
290397003561	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
290397003562	classical (c) SDRs; Region: SDR_c; cd05233
290397003563	NAD(P) binding site [chemical binding]; other site
290397003564	active site
290397003565	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
290397003566	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397003567	motif II; other site
290397003568	PEGA domain; Region: PEGA; pfam08308
290397003569	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
290397003570	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290397003571	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
290397003572	metal ion-dependent adhesion site (MIDAS); other site
290397003573	Protein of unknown function (DUF1355); Region: DUF1355; pfam07090
290397003574	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
290397003575	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290397003576	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
290397003577	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397003578	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
290397003579	helicase 45; Provisional; Region: PTZ00424
290397003580	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290397003581	ATP binding site [chemical binding]; other site
290397003582	Mg++ binding site [ion binding]; other site
290397003583	motif III; other site
290397003584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397003585	nucleotide binding region [chemical binding]; other site
290397003586	ATP-binding site [chemical binding]; other site
290397003587	PAS fold; Region: PAS_4; pfam08448
290397003588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397003589	putative active site [active]
290397003590	heme pocket [chemical binding]; other site
290397003591	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397003592	putative active site [active]
290397003593	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290397003594	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397003595	SpoVR like protein; Region: SpoVR; pfam04293
290397003596	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
290397003597	hypothetical protein; Provisional; Region: PRK05325
290397003598	PrkA AAA domain; Region: AAA_PrkA; smart00763
290397003599	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
290397003600	YceG-like family; Region: YceG; pfam02618
290397003601	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
290397003602	dimerization interface [polypeptide binding]; other site
290397003603	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
290397003604	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
290397003605	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397003606	DNA-binding site [nucleotide binding]; DNA binding site
290397003607	RNA-binding motif; other site
290397003608	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
290397003609	rRNA binding site [nucleotide binding]; other site
290397003610	predicted 30S ribosome binding site; other site
290397003611	Transglycosylase; Region: Transgly; pfam00912
290397003612	TonB C terminal; Region: TonB_2; pfam13103
290397003613	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
290397003614	active site
290397003615	dimer interfaces [polypeptide binding]; other site
290397003616	catalytic residues [active]
290397003617	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
290397003618	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290397003619	tetramer interface [polypeptide binding]; other site
290397003620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397003621	catalytic residue [active]
290397003622	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
290397003623	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290397003624	tetramer interface [polypeptide binding]; other site
290397003625	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397003626	catalytic residue [active]
290397003627	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290397003628	lipoyl attachment site [posttranslational modification]; other site
290397003629	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
290397003630	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
290397003631	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397003632	active site
290397003633	metal binding site [ion binding]; metal-binding site
290397003634	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14182
290397003635	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
290397003636	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
290397003637	homodimer interface [polypeptide binding]; other site
290397003638	NADP binding site [chemical binding]; other site
290397003639	substrate binding site [chemical binding]; other site
290397003640	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
290397003641	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397003642	active site
290397003643	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
290397003644	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
290397003645	putative active site [active]
290397003646	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397003647	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
290397003648	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
290397003649	active site
290397003650	substrate binding site [chemical binding]; other site
290397003651	cosubstrate binding site; other site
290397003652	catalytic site [active]
290397003653	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
290397003654	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
290397003655	dimerization interface [polypeptide binding]; other site
290397003656	putative ATP binding site [chemical binding]; other site
290397003657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397003658	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
290397003659	ligand binding site [chemical binding]; other site
290397003660	flexible hinge region; other site
290397003661	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
290397003662	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290397003663	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
290397003664	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397003665	AMIN domain; Region: AMIN; pfam11741
290397003666	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
290397003667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397003668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397003669	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
290397003670	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
290397003671	ligand binding site [chemical binding]; other site
290397003672	NAD binding site [chemical binding]; other site
290397003673	dimerization interface [polypeptide binding]; other site
290397003674	catalytic site [active]
290397003675	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
290397003676	putative L-serine binding site [chemical binding]; other site
290397003677	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
290397003678	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
290397003679	dimer interface [polypeptide binding]; other site
290397003680	motif 1; other site
290397003681	active site
290397003682	motif 2; other site
290397003683	motif 3; other site
290397003684	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
290397003685	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
290397003686	GDP-binding site [chemical binding]; other site
290397003687	ACT binding site; other site
290397003688	IMP binding site; other site
290397003689	TPR repeat; Region: TPR_11; pfam13414
290397003690	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397003691	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397003692	phosphopeptide binding site; other site
290397003693	Competence protein; Region: Competence; cl00471
290397003694	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
290397003695	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397003696	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
290397003697	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
290397003698	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
290397003699	substrate binding site; other site
290397003700	dimer interface; other site
290397003701	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
290397003702	homotrimer interaction site [polypeptide binding]; other site
290397003703	zinc binding site [ion binding]; other site
290397003704	CDP-binding sites; other site
290397003705	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
290397003706	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290397003707	active site
290397003708	HIGH motif; other site
290397003709	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290397003710	KMSKS motif; other site
290397003711	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
290397003712	tRNA binding surface [nucleotide binding]; other site
290397003713	anticodon binding site; other site
290397003714	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397003715	DNA-binding site [nucleotide binding]; DNA binding site
290397003716	RNA-binding motif; other site
290397003717	excinuclease ABC subunit B; Provisional; Region: PRK05298
290397003718	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397003719	ATP binding site [chemical binding]; other site
290397003720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397003721	nucleotide binding region [chemical binding]; other site
290397003722	ATP-binding site [chemical binding]; other site
290397003723	Ultra-violet resistance protein B; Region: UvrB; pfam12344
290397003724	UvrB/uvrC motif; Region: UVR; pfam02151
290397003725	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397003726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003727	active site
290397003728	phosphorylation site [posttranslational modification]
290397003729	intermolecular recognition site; other site
290397003730	dimerization interface [polypeptide binding]; other site
290397003731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397003732	Walker A motif; other site
290397003733	ATP binding site [chemical binding]; other site
290397003734	Walker B motif; other site
290397003735	arginine finger; other site
290397003736	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397003737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397003738	dimerization interface [polypeptide binding]; other site
290397003739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003740	dimer interface [polypeptide binding]; other site
290397003741	phosphorylation site [posttranslational modification]
290397003742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003743	ATP binding site [chemical binding]; other site
290397003744	Mg2+ binding site [ion binding]; other site
290397003745	G-X-G motif; other site
290397003746	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
290397003747	Cytochrome c; Region: Cytochrom_C; pfam00034
290397003748	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
290397003749	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
290397003750	GIY-YIG motif/motif A; other site
290397003751	active site
290397003752	catalytic site [active]
290397003753	putative DNA binding site [nucleotide binding]; other site
290397003754	metal binding site [ion binding]; metal-binding site
290397003755	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
290397003756	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
290397003757	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290397003758	dimer interface [polypeptide binding]; other site
290397003759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397003760	catalytic residue [active]
290397003761	serine O-acetyltransferase; Region: cysE; TIGR01172
290397003762	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
290397003763	trimer interface [polypeptide binding]; other site
290397003764	active site
290397003765	substrate binding site [chemical binding]; other site
290397003766	CoA binding site [chemical binding]; other site
290397003767	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
290397003768	dimer interface [polypeptide binding]; other site
290397003769	substrate binding site [chemical binding]; other site
290397003770	metal binding sites [ion binding]; metal-binding site
290397003771	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
290397003772	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397003773	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
290397003774	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
290397003775	Walker A motif; other site
290397003776	ATP binding site [chemical binding]; other site
290397003777	Walker B motif; other site
290397003778	Ycf46; Provisional; Region: ycf46; CHL00195
290397003779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290397003780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
290397003781	Coenzyme A binding pocket [chemical binding]; other site
290397003782	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
290397003783	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290397003784	active site
290397003785	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
290397003786	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
290397003787	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
290397003788	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
290397003789	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
290397003790	putative acyl-acceptor binding pocket; other site
290397003791	chaperone protein DnaJ; Provisional; Region: PRK14299
290397003792	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397003793	HSP70 interaction site [polypeptide binding]; other site
290397003794	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
290397003795	substrate binding site [polypeptide binding]; other site
290397003796	dimer interface [polypeptide binding]; other site
290397003797	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
290397003798	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397003799	Coenzyme A binding pocket [chemical binding]; other site
290397003800	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
290397003801	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
290397003802	quinone interaction residues [chemical binding]; other site
290397003803	active site
290397003804	catalytic residues [active]
290397003805	FMN binding site [chemical binding]; other site
290397003806	substrate binding site [chemical binding]; other site
290397003807	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
290397003808	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
290397003809	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397003810	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397003811	catalytic residue [active]
290397003812	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
290397003813	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397003814	FeS/SAM binding site; other site
290397003815	TPR repeat; Region: TPR_11; pfam13414
290397003816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397003817	binding surface
290397003818	TPR motif; other site
290397003819	TPR repeat; Region: TPR_11; pfam13414
290397003820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397003821	binding surface
290397003822	TPR motif; other site
290397003823	Helix-turn-helix domain; Region: HTH_25; pfam13413
290397003824	non-specific DNA binding site [nucleotide binding]; other site
290397003825	salt bridge; other site
290397003826	sequence-specific DNA binding site [nucleotide binding]; other site
290397003827	Recombination protein O N terminal; Region: RecO_N; pfam11967
290397003828	DNA repair protein RecO; Region: reco; TIGR00613
290397003829	Recombination protein O C terminal; Region: RecO_C; pfam02565
290397003830	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290397003831	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
290397003832	putative substrate binding site [chemical binding]; other site
290397003833	putative ATP binding site [chemical binding]; other site
290397003834	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
290397003835	dimer interface [polypeptide binding]; other site
290397003836	motif 1; other site
290397003837	active site
290397003838	motif 2; other site
290397003839	motif 3; other site
290397003840	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
290397003841	DALR anticodon binding domain; Region: DALR_1; smart00836
290397003842	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397003843	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397003844	phosphopeptide binding site; other site
290397003845	DNA polymerase I; Provisional; Region: PRK05755
290397003846	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
290397003847	active site
290397003848	metal binding site 1 [ion binding]; metal-binding site
290397003849	putative 5' ssDNA interaction site; other site
290397003850	metal binding site 3; metal-binding site
290397003851	metal binding site 2 [ion binding]; metal-binding site
290397003852	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
290397003853	putative DNA binding site [nucleotide binding]; other site
290397003854	putative metal binding site [ion binding]; other site
290397003855	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
290397003856	active site
290397003857	substrate binding site [chemical binding]; other site
290397003858	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
290397003859	active site
290397003860	DNA binding site [nucleotide binding]
290397003861	catalytic site [active]
290397003862	DivIVA protein; Region: DivIVA; pfam05103
290397003863	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
290397003864	DNA polymerase III subunit delta'; Validated; Region: PRK08485
290397003865	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
290397003866	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
290397003867	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
290397003868	active site
290397003869	HIGH motif; other site
290397003870	KMSKS motif; other site
290397003871	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
290397003872	anticodon binding site; other site
290397003873	tRNA binding surface [nucleotide binding]; other site
290397003874	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
290397003875	dimer interface [polypeptide binding]; other site
290397003876	putative tRNA-binding site [nucleotide binding]; other site
290397003877	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
290397003878	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
290397003879	active site
290397003880	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
290397003881	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290397003882	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
290397003883	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
290397003884	generic binding surface I; other site
290397003885	generic binding surface II; other site
290397003886	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397003887	Zn2+ binding site [ion binding]; other site
290397003888	Mg2+ binding site [ion binding]; other site
290397003889	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
290397003890	Isochorismatase family; Region: Isochorismatase; pfam00857
290397003891	catalytic triad [active]
290397003892	metal binding site [ion binding]; metal-binding site
290397003893	conserved cis-peptide bond; other site
290397003894	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
290397003895	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
290397003896	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
290397003897	NAD binding site [chemical binding]; other site
290397003898	catalytic Zn binding site [ion binding]; other site
290397003899	structural Zn binding site [ion binding]; other site
290397003900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397003901	Ligand Binding Site [chemical binding]; other site
290397003902	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290397003903	FOG: CBS domain [General function prediction only]; Region: COG0517
290397003904	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290397003905	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
290397003906	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
290397003907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397003908	FeS/SAM binding site; other site
290397003909	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397003910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003911	active site
290397003912	phosphorylation site [posttranslational modification]
290397003913	intermolecular recognition site; other site
290397003914	dimerization interface [polypeptide binding]; other site
290397003915	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397003916	Walker A motif; other site
290397003917	ATP binding site [chemical binding]; other site
290397003918	Walker B motif; other site
290397003919	arginine finger; other site
290397003920	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397003921	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003923	active site
290397003924	phosphorylation site [posttranslational modification]
290397003925	intermolecular recognition site; other site
290397003926	dimerization interface [polypeptide binding]; other site
290397003927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003928	dimer interface [polypeptide binding]; other site
290397003929	phosphorylation site [posttranslational modification]
290397003930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003931	ATP binding site [chemical binding]; other site
290397003932	Mg2+ binding site [ion binding]; other site
290397003933	G-X-G motif; other site
290397003934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003935	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003936	active site
290397003937	phosphorylation site [posttranslational modification]
290397003938	intermolecular recognition site; other site
290397003939	dimerization interface [polypeptide binding]; other site
290397003940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397003941	Response regulator receiver domain; Region: Response_reg; pfam00072
290397003942	active site
290397003943	phosphorylation site [posttranslational modification]
290397003944	intermolecular recognition site; other site
290397003945	dimerization interface [polypeptide binding]; other site
290397003946	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
290397003947	heme-binding site [chemical binding]; other site
290397003948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397003949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397003950	dimer interface [polypeptide binding]; other site
290397003951	phosphorylation site [posttranslational modification]
290397003952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397003953	ATP binding site [chemical binding]; other site
290397003954	Mg2+ binding site [ion binding]; other site
290397003955	G-X-G motif; other site
290397003956	FOG: CBS domain [General function prediction only]; Region: COG0517
290397003957	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803
290397003958	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397003959	Ligand Binding Site [chemical binding]; other site
290397003960	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
290397003961	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
290397003962	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397003963	ligand binding site [chemical binding]; other site
290397003964	flexible hinge region; other site
290397003965	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
290397003966	DNA binding site [nucleotide binding]
290397003967	sequence specific DNA binding site [nucleotide binding]; other site
290397003968	putative cAMP binding site [chemical binding]; other site
290397003969	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
290397003970	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
290397003971	dimer interface [polypeptide binding]; other site
290397003972	putative functional site; other site
290397003973	putative MPT binding site; other site
290397003974	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
290397003975	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
290397003976	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290397003977	PilZ domain; Region: PilZ; cl01260
290397003978	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
290397003979	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290397003980	putative metal binding site; other site
290397003981	Flagellar protein FliS; Region: FliS; cl00654
290397003982	flagellin; Provisional; Region: PRK12802
290397003983	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
290397003984	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
290397003985	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
290397003986	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
290397003987	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
290397003988	flagellin; Provisional; Region: PRK12802
290397003989	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
290397003990	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
290397003991	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
290397003992	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
290397003993	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
290397003994	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
290397003995	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290397003996	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397003997	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
290397003998	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
290397003999	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
290397004000	Flagellar L-ring protein; Region: FlgH; pfam02107
290397004001	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
290397004002	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
290397004003	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
290397004004	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
290397004005	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
290397004006	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
290397004007	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
290397004008	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
290397004009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397004010	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
290397004011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397004012	DNA binding residues [nucleotide binding]
290397004013	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397004014	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
290397004015	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
290397004016	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
290397004017	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397004018	FHIPEP family; Region: FHIPEP; pfam00771
290397004019	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
290397004020	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
290397004021	FHIPEP family; Region: FHIPEP; pfam00771
290397004022	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
290397004023	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
290397004024	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
290397004025	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
290397004026	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
290397004027	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
290397004028	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
290397004029	HDOD domain; Region: HDOD; pfam08668
290397004030	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397004031	Zn2+ binding site [ion binding]; other site
290397004032	Mg2+ binding site [ion binding]; other site
290397004033	Response regulator receiver domain; Region: Response_reg; pfam00072
290397004034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004035	active site
290397004036	phosphorylation site [posttranslational modification]
290397004037	intermolecular recognition site; other site
290397004038	dimerization interface [polypeptide binding]; other site
290397004039	Response regulator receiver domain; Region: Response_reg; pfam00072
290397004040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004041	active site
290397004042	phosphorylation site [posttranslational modification]
290397004043	intermolecular recognition site; other site
290397004044	dimerization interface [polypeptide binding]; other site
290397004045	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
290397004046	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397004047	putative binding surface; other site
290397004048	active site
290397004049	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
290397004050	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
290397004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004052	ATP binding site [chemical binding]; other site
290397004053	Mg2+ binding site [ion binding]; other site
290397004054	G-X-G motif; other site
290397004055	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
290397004056	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290397004057	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397004058	CheD chemotactic sensory transduction; Region: CheD; cl00810
290397004059	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397004060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004061	active site
290397004062	phosphorylation site [posttranslational modification]
290397004063	intermolecular recognition site; other site
290397004064	CheB methylesterase; Region: CheB_methylest; pfam01339
290397004065	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397004066	dimer interface [polypeptide binding]; other site
290397004067	putative CheW interface [polypeptide binding]; other site
290397004068	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
290397004069	putative CheA interaction surface; other site
290397004070	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397004071	Response regulator receiver domain; Region: Response_reg; pfam00072
290397004072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004073	active site
290397004074	phosphorylation site [posttranslational modification]
290397004075	intermolecular recognition site; other site
290397004076	dimerization interface [polypeptide binding]; other site
290397004077	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397004078	putative binding surface; other site
290397004079	active site
290397004080	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
290397004081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004082	ATP binding site [chemical binding]; other site
290397004083	Mg2+ binding site [ion binding]; other site
290397004084	G-X-G motif; other site
290397004085	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
290397004086	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
290397004087	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397004088	dimerization interface [polypeptide binding]; other site
290397004089	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397004090	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397004091	dimer interface [polypeptide binding]; other site
290397004092	putative CheW interface [polypeptide binding]; other site
290397004093	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
290397004094	putative CheA interaction surface; other site
290397004095	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
290397004096	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
290397004097	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397004098	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397004099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004100	active site
290397004101	phosphorylation site [posttranslational modification]
290397004102	intermolecular recognition site; other site
290397004103	dimerization interface [polypeptide binding]; other site
290397004104	CheB methylesterase; Region: CheB_methylest; pfam01339
290397004105	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
290397004106	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
290397004107	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397004108	ligand binding site [chemical binding]; other site
290397004109	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
290397004110	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
290397004111	Flagellar protein (FlbD); Region: FlbD; pfam06289
290397004112	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
290397004113	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
290397004114	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
290397004115	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
290397004116	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
290397004117	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
290397004118	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
290397004119	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290397004120	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397004121	Walker A motif; other site
290397004122	ATP binding site [chemical binding]; other site
290397004123	Walker B motif; other site
290397004124	Flagellar assembly protein FliH; Region: FliH; pfam02108
290397004125	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
290397004126	FliG C-terminal domain; Region: FliG_C; pfam01706
290397004127	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
290397004128	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
290397004129	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
290397004130	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
290397004131	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
290397004132	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
290397004133	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
290397004134	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
290397004135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004136	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397004137	Walker A motif; other site
290397004138	ATP binding site [chemical binding]; other site
290397004139	Walker B motif; other site
290397004140	arginine finger; other site
290397004141	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397004142	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
290397004143	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
290397004144	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
290397004145	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397004146	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397004147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004148	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397004149	Walker A motif; other site
290397004150	ATP binding site [chemical binding]; other site
290397004151	Walker B motif; other site
290397004152	arginine finger; other site
290397004153	Hemerythrin-like domain; Region: Hr-like; cd12108
290397004154	Fe binding site [ion binding]; other site
290397004155	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
290397004156	methionine aminopeptidase; Provisional; Region: PRK12318
290397004157	SEC-C motif; Region: SEC-C; pfam02810
290397004158	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
290397004159	active site
290397004160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397004161	Walker A/P-loop; other site
290397004162	ATP binding site [chemical binding]; other site
290397004163	Q-loop/lid; other site
290397004164	ABC transporter signature motif; other site
290397004165	Walker B; other site
290397004166	D-loop; other site
290397004167	H-loop/switch region; other site
290397004168	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
290397004169	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290397004170	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
290397004171	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
290397004172	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
290397004173	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397004174	active site
290397004175	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397004176	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397004177	active site
290397004178	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
290397004179	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
290397004180	putative NAD(P) binding site [chemical binding]; other site
290397004181	putative substrate binding site [chemical binding]; other site
290397004182	catalytic Zn binding site [ion binding]; other site
290397004183	structural Zn binding site [ion binding]; other site
290397004184	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
290397004185	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
290397004186	Zn binding site [ion binding]; other site
290397004187	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
290397004188	Cl- selectivity filter; other site
290397004189	Cl- binding residues [ion binding]; other site
290397004190	pore gating glutamate residue; other site
290397004191	dimer interface [polypeptide binding]; other site
290397004192	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290397004193	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
290397004194	4Fe-4S binding domain; Region: Fer4; pfam00037
290397004195	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290397004196	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290397004197	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
290397004198	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
290397004199	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
290397004200	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
290397004201	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
290397004202	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
290397004203	DTW domain; Region: DTW; cl01221
290397004204	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397004205	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290397004206	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
290397004207	D-cysteine desulfhydrase; Validated; Region: PRK03910
290397004208	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
290397004209	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397004210	catalytic residue [active]
290397004211	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290397004212	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
290397004213	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
290397004214	active site
290397004215	nucleophile elbow; other site
290397004216	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
290397004217	EamA-like transporter family; Region: EamA; pfam00892
290397004218	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
290397004219	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
290397004220	active site
290397004221	catalytic residues [active]
290397004222	metal binding site [ion binding]; metal-binding site
290397004223	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290397004224	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397004225	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290397004226	acyl-activating enzyme (AAE) consensus motif; other site
290397004227	putative AMP binding site [chemical binding]; other site
290397004228	putative active site [active]
290397004229	putative CoA binding site [chemical binding]; other site
290397004230	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
290397004231	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
290397004232	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
290397004233	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
290397004234	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
290397004235	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
290397004236	putative active site [active]
290397004237	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
290397004238	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
290397004239	active site
290397004240	homotetramer interface [polypeptide binding]; other site
290397004241	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
290397004242	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
290397004243	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
290397004244	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
290397004245	Cl- selectivity filter; other site
290397004246	Cl- binding residues [ion binding]; other site
290397004247	pore gating glutamate residue; other site
290397004248	dimer interface [polypeptide binding]; other site
290397004249	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
290397004250	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290397004251	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397004252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397004253	DNA binding residues [nucleotide binding]
290397004254	dimerization interface [polypeptide binding]; other site
290397004255	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397004256	Ligand Binding Site [chemical binding]; other site
290397004257	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397004258	Ligand Binding Site [chemical binding]; other site
290397004259	AAA domain; Region: AAA_32; pfam13654
290397004260	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
290397004261	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397004262	Ligand Binding Site [chemical binding]; other site
290397004263	FOG: CBS domain [General function prediction only]; Region: COG0517
290397004264	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
290397004265	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397004266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004267	active site
290397004268	phosphorylation site [posttranslational modification]
290397004269	intermolecular recognition site; other site
290397004270	dimerization interface [polypeptide binding]; other site
290397004271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004272	Walker A motif; other site
290397004273	ATP binding site [chemical binding]; other site
290397004274	Walker B motif; other site
290397004275	arginine finger; other site
290397004276	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397004277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397004279	dimer interface [polypeptide binding]; other site
290397004280	phosphorylation site [posttranslational modification]
290397004281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004282	ATP binding site [chemical binding]; other site
290397004283	G-X-G motif; other site
290397004284	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397004285	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397004286	active site
290397004287	metal binding site [ion binding]; metal-binding site
290397004288	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290397004289	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
290397004290	YceI-like domain; Region: YceI; smart00867
290397004291	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
290397004292	30S subunit binding site; other site
290397004293	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397004294	DNA-binding site [nucleotide binding]; DNA binding site
290397004295	RNA-binding motif; other site
290397004296	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
290397004297	Cupin domain; Region: Cupin_2; cl17218
290397004298	Cupin domain; Region: Cupin_2; cl17218
290397004299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397004300	S-adenosylmethionine binding site [chemical binding]; other site
290397004301	YciI-like protein; Reviewed; Region: PRK12866
290397004302	integrase; Provisional; Region: int; PHA02601
290397004303	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
290397004304	active site
290397004305	catalytic residues [active]
290397004306	DNA binding site [nucleotide binding]
290397004307	Int/Topo IB signature motif; other site
290397004308	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290397004309	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290397004310	catalytic residues [active]
290397004311	catalytic nucleophile [active]
290397004312	Presynaptic Site I dimer interface [polypeptide binding]; other site
290397004313	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290397004314	Synaptic Flat tetramer interface [polypeptide binding]; other site
290397004315	Synaptic Site I dimer interface [polypeptide binding]; other site
290397004316	DNA binding site [nucleotide binding]
290397004317	PAS domain; Region: PAS_9; pfam13426
290397004318	PAS domain S-box; Region: sensory_box; TIGR00229
290397004319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397004320	putative active site [active]
290397004321	heme pocket [chemical binding]; other site
290397004322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397004324	dimer interface [polypeptide binding]; other site
290397004325	phosphorylation site [posttranslational modification]
290397004326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004327	Mg2+ binding site [ion binding]; other site
290397004328	G-X-G motif; other site
290397004329	PAS domain; Region: PAS; smart00091
290397004330	PAS fold; Region: PAS_4; pfam08448
290397004331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397004332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004333	dimer interface [polypeptide binding]; other site
290397004334	phosphorylation site [posttranslational modification]
290397004335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004336	ATP binding site [chemical binding]; other site
290397004337	Mg2+ binding site [ion binding]; other site
290397004338	G-X-G motif; other site
290397004339	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397004340	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397004341	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397004342	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397004343	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397004344	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
290397004345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004346	Walker A motif; other site
290397004347	ATP binding site [chemical binding]; other site
290397004348	Walker B motif; other site
290397004349	arginine finger; other site
290397004350	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
290397004351	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
290397004352	active site
290397004353	NTP binding site [chemical binding]; other site
290397004354	metal binding triad [ion binding]; metal-binding site
290397004355	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
290397004356	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
290397004357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004358	active site
290397004359	phosphorylation site [posttranslational modification]
290397004360	intermolecular recognition site; other site
290397004361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397004363	dimer interface [polypeptide binding]; other site
290397004364	phosphorylation site [posttranslational modification]
290397004365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004366	ATP binding site [chemical binding]; other site
290397004367	Mg2+ binding site [ion binding]; other site
290397004368	G-X-G motif; other site
290397004369	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
290397004370	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
290397004371	Ligand Binding Site [chemical binding]; other site
290397004372	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
290397004373	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290397004374	B12 binding site [chemical binding]; other site
290397004375	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
290397004376	active site 2 [active]
290397004377	active site 1 [active]
290397004378	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
290397004379	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
290397004380	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290397004381	IHF dimer interface [polypeptide binding]; other site
290397004382	IHF - DNA interface [nucleotide binding]; other site
290397004383	PilZ domain; Region: PilZ; pfam07238
290397004384	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
290397004385	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
290397004386	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
290397004387	FtsH Extracellular; Region: FtsH_ext; pfam06480
290397004388	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290397004389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004390	Walker A motif; other site
290397004391	ATP binding site [chemical binding]; other site
290397004392	Walker B motif; other site
290397004393	arginine finger; other site
290397004394	Peptidase family M41; Region: Peptidase_M41; pfam01434
290397004395	dihydropteroate synthase; Region: DHPS; TIGR01496
290397004396	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
290397004397	substrate binding pocket [chemical binding]; other site
290397004398	dimer interface [polypeptide binding]; other site
290397004399	inhibitor binding site; inhibition site
290397004400	Uncharacterized conserved protein [Function unknown]; Region: COG1624
290397004401	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
290397004402	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
290397004403	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
290397004404	active site
290397004405	substrate binding site [chemical binding]; other site
290397004406	metal binding site [ion binding]; metal-binding site
290397004407	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
290397004408	active site
290397004409	hydrophilic channel; other site
290397004410	dimerization interface [polypeptide binding]; other site
290397004411	catalytic residues [active]
290397004412	active site lid [active]
290397004413	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
290397004414	Uncharacterized conserved protein [Function unknown]; Region: COG0062
290397004415	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
290397004416	putative substrate binding site [chemical binding]; other site
290397004417	putative ATP binding site [chemical binding]; other site
290397004418	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
290397004419	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
290397004420	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
290397004421	putative active site [active]
290397004422	putative dimer interface [polypeptide binding]; other site
290397004423	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
290397004424	active site
290397004425	metal binding site [ion binding]; metal-binding site
290397004426	homotetramer interface [polypeptide binding]; other site
290397004427	imidazolonepropionase; Validated; Region: PRK09356
290397004428	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397004429	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397004430	active site
290397004431	urocanate hydratase; Provisional; Region: PRK05414
290397004432	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
290397004433	histidyl-tRNA synthetase; Region: hisS; TIGR00442
290397004434	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
290397004435	dimer interface [polypeptide binding]; other site
290397004436	motif 1; other site
290397004437	active site
290397004438	motif 2; other site
290397004439	motif 3; other site
290397004440	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
290397004441	anticodon binding site; other site
290397004442	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
290397004443	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
290397004444	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
290397004445	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
290397004446	cytidylate kinase; Provisional; Region: cmk; PRK00023
290397004447	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
290397004448	CMP-binding site; other site
290397004449	The sites determining sugar specificity; other site
290397004450	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
290397004451	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
290397004452	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
290397004453	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
290397004454	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
290397004455	RNA binding site [nucleotide binding]; other site
290397004456	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
290397004457	RNA binding site [nucleotide binding]; other site
290397004458	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
290397004459	RNA binding site [nucleotide binding]; other site
290397004460	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290397004461	RNA binding site [nucleotide binding]; other site
290397004462	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
290397004463	RNA binding site [nucleotide binding]; other site
290397004464	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
290397004465	RNA binding site [nucleotide binding]; other site
290397004466	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
290397004467	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
290397004468	tandem repeat interface [polypeptide binding]; other site
290397004469	oligomer interface [polypeptide binding]; other site
290397004470	active site residues [active]
290397004471	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
290397004472	nucleotide binding site/active site [active]
290397004473	HIT family signature motif; other site
290397004474	catalytic residue [active]
290397004475	tetratricopeptide repeat protein; Provisional; Region: PRK11788
290397004476	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
290397004477	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
290397004478	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
290397004479	active site
290397004480	HIGH motif; other site
290397004481	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397004482	KMSK motif region; other site
290397004483	tRNA binding surface [nucleotide binding]; other site
290397004484	DALR anticodon binding domain; Region: DALR_1; smart00836
290397004485	anticodon binding site; other site
290397004486	Sporulation related domain; Region: SPOR; pfam05036
290397004487	Cupin domain; Region: Cupin_2; cl17218
290397004488	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
290397004489	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
290397004490	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
290397004491	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
290397004492	Phosphoglycerate kinase; Region: PGK; pfam00162
290397004493	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
290397004494	substrate binding site [chemical binding]; other site
290397004495	hinge regions; other site
290397004496	ADP binding site [chemical binding]; other site
290397004497	catalytic site [active]
290397004498	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
290397004499	substrate binding site [chemical binding]; other site
290397004500	dimer interface [polypeptide binding]; other site
290397004501	catalytic triad [active]
290397004502	Preprotein translocase SecG subunit; Region: SecG; pfam03840
290397004503	Ferredoxin [Energy production and conversion]; Region: COG1146
290397004504	4Fe-4S binding domain; Region: Fer4; pfam00037
290397004505	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
290397004506	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
290397004507	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
290397004508	putative chaperone; Provisional; Region: PRK11678
290397004509	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
290397004510	nucleotide binding site [chemical binding]; other site
290397004511	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290397004512	SBD interface [polypeptide binding]; other site
290397004513	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
290397004514	ATP binding site [chemical binding]; other site
290397004515	substrate interface [chemical binding]; other site
290397004516	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
290397004517	CPxP  motif; other site
290397004518	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
290397004519	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
290397004520	ATP binding site [chemical binding]; other site
290397004521	substrate interface [chemical binding]; other site
290397004522	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290397004523	active site
290397004524	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
290397004525	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
290397004526	Ligand Binding Site [chemical binding]; other site
290397004527	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
290397004528	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
290397004529	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
290397004530	dimerization interface 3.5A [polypeptide binding]; other site
290397004531	active site
290397004532	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
290397004533	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
290397004534	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290397004535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004536	Walker A motif; other site
290397004537	ATP binding site [chemical binding]; other site
290397004538	Walker B motif; other site
290397004539	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290397004540	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397004541	nucleotide binding site [chemical binding]; other site
290397004542	PrkA AAA domain; Region: AAA_PrkA; smart00763
290397004543	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
290397004544	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397004545	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
290397004546	catalytic motif [active]
290397004547	Zn binding site [ion binding]; other site
290397004548	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
290397004549	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
290397004550	putative active site [active]
290397004551	putative metal binding site [ion binding]; other site
290397004552	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397004553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004554	active site
290397004555	phosphorylation site [posttranslational modification]
290397004556	intermolecular recognition site; other site
290397004557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397004558	Walker A motif; other site
290397004559	ATP binding site [chemical binding]; other site
290397004560	Walker B motif; other site
290397004561	arginine finger; other site
290397004562	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397004563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004564	Response regulator receiver domain; Region: Response_reg; pfam00072
290397004565	active site
290397004566	phosphorylation site [posttranslational modification]
290397004567	intermolecular recognition site; other site
290397004568	dimerization interface [polypeptide binding]; other site
290397004569	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397004570	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397004571	metal binding site [ion binding]; metal-binding site
290397004572	active site
290397004573	I-site; other site
290397004574	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397004575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397004576	binding surface
290397004577	TPR motif; other site
290397004578	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
290397004579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004581	ATP binding site [chemical binding]; other site
290397004582	Mg2+ binding site [ion binding]; other site
290397004583	G-X-G motif; other site
290397004584	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
290397004585	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290397004586	metal binding site 2 [ion binding]; metal-binding site
290397004587	putative DNA binding helix; other site
290397004588	metal binding site 1 [ion binding]; metal-binding site
290397004589	dimer interface [polypeptide binding]; other site
290397004590	structural Zn2+ binding site [ion binding]; other site
290397004591	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
290397004592	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
290397004593	G1 box; other site
290397004594	GTP/Mg2+ binding site [chemical binding]; other site
290397004595	Switch I region; other site
290397004596	G2 box; other site
290397004597	G3 box; other site
290397004598	Switch II region; other site
290397004599	G4 box; other site
290397004600	G5 box; other site
290397004601	Nucleoside recognition; Region: Gate; pfam07670
290397004602	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
290397004603	Nucleoside recognition; Region: Gate; pfam07670
290397004604	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
290397004605	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
290397004606	FeoA domain; Region: FeoA; pfam04023
290397004607	FMN-binding domain; Region: FMN_bind; pfam04205
290397004608	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
290397004609	ApbE family; Region: ApbE; pfam02424
290397004610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397004611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397004612	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
290397004613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397004614	putative substrate translocation pore; other site
290397004615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397004616	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397004617	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
290397004618	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397004619	Septum formation initiator; Region: DivIC; pfam04977
290397004620	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
290397004621	GAF domain; Region: GAF; cl17456
290397004622	GAF domain; Region: GAF_2; pfam13185
290397004623	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397004624	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397004625	metal binding site [ion binding]; metal-binding site
290397004626	active site
290397004627	I-site; other site
290397004628	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
290397004629	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
290397004630	putative active site [active]
290397004631	PhoH-like protein; Region: PhoH; pfam02562
290397004632	Protein of unknown function (DUF493); Region: DUF493; pfam04359
290397004633	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
290397004634	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
290397004635	nucleotide binding site [chemical binding]; other site
290397004636	NEF interaction site [polypeptide binding]; other site
290397004637	SBD interface [polypeptide binding]; other site
290397004638	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
290397004639	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397004640	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
290397004641	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
290397004642	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290397004643	elongation factor Tu; Reviewed; Region: PRK00049
290397004644	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
290397004645	G1 box; other site
290397004646	GEF interaction site [polypeptide binding]; other site
290397004647	GTP/Mg2+ binding site [chemical binding]; other site
290397004648	Switch I region; other site
290397004649	G2 box; other site
290397004650	G3 box; other site
290397004651	Switch II region; other site
290397004652	G4 box; other site
290397004653	G5 box; other site
290397004654	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
290397004655	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
290397004656	Antibiotic Binding Site [chemical binding]; other site
290397004657	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
290397004658	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
290397004659	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
290397004660	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
290397004661	putative homodimer interface [polypeptide binding]; other site
290397004662	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
290397004663	heterodimer interface [polypeptide binding]; other site
290397004664	homodimer interface [polypeptide binding]; other site
290397004665	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
290397004666	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
290397004667	23S rRNA interface [nucleotide binding]; other site
290397004668	L7/L12 interface [polypeptide binding]; other site
290397004669	putative thiostrepton binding site; other site
290397004670	L25 interface [polypeptide binding]; other site
290397004671	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
290397004672	mRNA/rRNA interface [nucleotide binding]; other site
290397004673	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
290397004674	23S rRNA interface [nucleotide binding]; other site
290397004675	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
290397004676	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
290397004677	core dimer interface [polypeptide binding]; other site
290397004678	peripheral dimer interface [polypeptide binding]; other site
290397004679	L10 interface [polypeptide binding]; other site
290397004680	L11 interface [polypeptide binding]; other site
290397004681	putative EF-Tu interaction site [polypeptide binding]; other site
290397004682	putative EF-G interaction site [polypeptide binding]; other site
290397004683	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
290397004684	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
290397004685	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290397004686	RPB11 interaction site [polypeptide binding]; other site
290397004687	RPB12 interaction site [polypeptide binding]; other site
290397004688	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290397004689	RPB3 interaction site [polypeptide binding]; other site
290397004690	RPB1 interaction site [polypeptide binding]; other site
290397004691	RPB11 interaction site [polypeptide binding]; other site
290397004692	RPB10 interaction site [polypeptide binding]; other site
290397004693	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
290397004694	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
290397004695	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
290397004696	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
290397004697	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
290397004698	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
290397004699	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
290397004700	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
290397004701	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
290397004702	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
290397004703	DNA binding site [nucleotide binding]
290397004704	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
290397004705	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
290397004706	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290397004707	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397004708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290397004709	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
290397004710	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
290397004711	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290397004712	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397004713	Walker A motif; other site
290397004714	ATP binding site [chemical binding]; other site
290397004715	Walker B motif; other site
290397004716	Response regulator receiver domain; Region: Response_reg; pfam00072
290397004717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004718	active site
290397004719	phosphorylation site [posttranslational modification]
290397004720	intermolecular recognition site; other site
290397004721	dimerization interface [polypeptide binding]; other site
290397004722	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397004723	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290397004724	putative acyl-acceptor binding pocket; other site
290397004725	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
290397004726	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
290397004727	catalytic site [active]
290397004728	putative active site [active]
290397004729	putative substrate binding site [chemical binding]; other site
290397004730	HRDC domain; Region: HRDC; pfam00570
290397004731	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
290397004732	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397004733	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397004734	catalytic residue [active]
290397004735	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
290397004736	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
290397004737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004738	ATP binding site [chemical binding]; other site
290397004739	Mg2+ binding site [ion binding]; other site
290397004740	G-X-G motif; other site
290397004741	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
290397004742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397004743	active site
290397004744	phosphorylation site [posttranslational modification]
290397004745	intermolecular recognition site; other site
290397004746	dimerization interface [polypeptide binding]; other site
290397004747	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397004748	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397004749	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397004750	catalytic residues [active]
290397004751	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397004752	Walker A motif; other site
290397004753	ATP binding site [chemical binding]; other site
290397004754	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
290397004755	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
290397004756	putative active site [active]
290397004757	putative PHP Thumb interface [polypeptide binding]; other site
290397004758	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
290397004759	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
290397004760	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
290397004761	generic binding surface I; other site
290397004762	generic binding surface II; other site
290397004763	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
290397004764	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
290397004765	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
290397004766	active site
290397004767	dimer interface [polypeptide binding]; other site
290397004768	effector binding site; other site
290397004769	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290397004770	TSCPD domain; Region: TSCPD; pfam12637
290397004771	GTP-binding protein LepA; Provisional; Region: PRK05433
290397004772	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
290397004773	G1 box; other site
290397004774	putative GEF interaction site [polypeptide binding]; other site
290397004775	GTP/Mg2+ binding site [chemical binding]; other site
290397004776	Switch I region; other site
290397004777	G2 box; other site
290397004778	G3 box; other site
290397004779	Switch II region; other site
290397004780	G4 box; other site
290397004781	G5 box; other site
290397004782	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
290397004783	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
290397004784	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
290397004785	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
290397004786	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290397004787	Catalytic site [active]
290397004788	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290397004789	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397004790	active site
290397004791	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
290397004792	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290397004793	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290397004794	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397004795	dihydroorotase; Validated; Region: pyrC; PRK09357
290397004796	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
290397004797	active site
290397004798	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
290397004799	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
290397004800	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
290397004801	catalytic site [active]
290397004802	subunit interface [polypeptide binding]; other site
290397004803	Bifunctional nuclease; Region: DNase-RNase; cl00553
290397004804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397004805	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397004806	putative active site [active]
290397004807	heme pocket [chemical binding]; other site
290397004808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
290397004809	dimer interface [polypeptide binding]; other site
290397004810	phosphorylation site [posttranslational modification]
290397004811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004812	ATP binding site [chemical binding]; other site
290397004813	Mg2+ binding site [ion binding]; other site
290397004814	G-X-G motif; other site
290397004815	YdjC-like protein; Region: YdjC; pfam04794
290397004816	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
290397004817	isocitrate dehydrogenase; Validated; Region: PRK07362
290397004818	malate dehydrogenase; Reviewed; Region: PRK06223
290397004819	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
290397004820	NAD(P) binding site [chemical binding]; other site
290397004821	dimer interface [polypeptide binding]; other site
290397004822	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290397004823	substrate binding site [chemical binding]; other site
290397004824	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
290397004825	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
290397004826	CoA-ligase; Region: Ligase_CoA; pfam00549
290397004827	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
290397004828	CoA binding domain; Region: CoA_binding; pfam02629
290397004829	CoA-ligase; Region: Ligase_CoA; pfam00549
290397004830	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
290397004831	active site
290397004832	multimer interface [polypeptide binding]; other site
290397004833	Domain of unknown function DUF21; Region: DUF21; pfam01595
290397004834	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
290397004835	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
290397004836	Transporter associated domain; Region: CorC_HlyC; smart01091
290397004837	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
290397004838	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397004839	FeS/SAM binding site; other site
290397004840	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290397004841	substrate binding site [chemical binding]; other site
290397004842	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290397004843	ATP binding site [chemical binding]; other site
290397004844	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
290397004845	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397004846	active site
290397004847	metal binding site [ion binding]; metal-binding site
290397004848	PQQ-like domain; Region: PQQ_2; pfam13360
290397004849	Restriction endonuclease; Region: Mrr_cat; pfam04471
290397004850	HEAT repeats; Region: HEAT_2; pfam13646
290397004851	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
290397004852	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
290397004853	homoserine dehydrogenase; Provisional; Region: PRK06349
290397004854	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
290397004855	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
290397004856	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290397004857	active site
290397004858	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
290397004859	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
290397004860	putative active site [active]
290397004861	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
290397004862	hydrophobic ligand binding site; other site
290397004863	enolase; Provisional; Region: eno; PRK00077
290397004864	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
290397004865	dimer interface [polypeptide binding]; other site
290397004866	metal binding site [ion binding]; metal-binding site
290397004867	substrate binding pocket [chemical binding]; other site
290397004868	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
290397004869	ThiC family; Region: ThiC; pfam01964
290397004870	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
290397004871	active site
290397004872	catalytic residues [active]
290397004873	metal binding site [ion binding]; metal-binding site
290397004874	enoyl-CoA hydratase; Provisional; Region: PRK06688
290397004875	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397004876	substrate binding site [chemical binding]; other site
290397004877	oxyanion hole (OAH) forming residues; other site
290397004878	trimer interface [polypeptide binding]; other site
290397004879	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
290397004880	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290397004881	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290397004882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397004883	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397004884	active site
290397004885	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
290397004886	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397004887	ribonuclease III; Reviewed; Region: rnc; PRK00102
290397004888	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
290397004889	dimerization interface [polypeptide binding]; other site
290397004890	active site
290397004891	metal binding site [ion binding]; metal-binding site
290397004892	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
290397004893	dsRNA binding site [nucleotide binding]; other site
290397004894	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290397004895	active site
290397004896	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290397004897	active site
290397004898	GTPase Era; Reviewed; Region: era; PRK00089
290397004899	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
290397004900	G1 box; other site
290397004901	GTP/Mg2+ binding site [chemical binding]; other site
290397004902	Switch I region; other site
290397004903	G2 box; other site
290397004904	Switch II region; other site
290397004905	G3 box; other site
290397004906	G4 box; other site
290397004907	G5 box; other site
290397004908	KH domain; Region: KH_2; pfam07650
290397004909	GTP-binding protein Der; Reviewed; Region: PRK00093
290397004910	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
290397004911	G1 box; other site
290397004912	GTP/Mg2+ binding site [chemical binding]; other site
290397004913	Switch I region; other site
290397004914	G2 box; other site
290397004915	Switch II region; other site
290397004916	G3 box; other site
290397004917	G4 box; other site
290397004918	G5 box; other site
290397004919	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
290397004920	G1 box; other site
290397004921	GTP/Mg2+ binding site [chemical binding]; other site
290397004922	Switch I region; other site
290397004923	G2 box; other site
290397004924	G3 box; other site
290397004925	Switch II region; other site
290397004926	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
290397004927	G4 box; other site
290397004928	G5 box; other site
290397004929	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
290397004930	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
290397004931	PQQ-like domain; Region: PQQ_2; pfam13360
290397004932	Trp docking motif [polypeptide binding]; other site
290397004933	active site
290397004934	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
290397004935	active site
290397004936	8-oxo-dGMP binding site [chemical binding]; other site
290397004937	nudix motif; other site
290397004938	metal binding site [ion binding]; metal-binding site
290397004939	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
290397004940	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
290397004941	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
290397004942	DNA binding residues [nucleotide binding]
290397004943	dimer interface [polypeptide binding]; other site
290397004944	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
290397004945	dimerization interface [polypeptide binding]; other site
290397004946	active site
290397004947	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397004948	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397004949	active site
290397004950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397004951	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
290397004952	FAD binding site [chemical binding]; other site
290397004953	homotetramer interface [polypeptide binding]; other site
290397004954	substrate binding pocket [chemical binding]; other site
290397004955	catalytic base [active]
290397004956	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
290397004957	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397004958	substrate binding site [chemical binding]; other site
290397004959	oxyanion hole (OAH) forming residues; other site
290397004960	trimer interface [polypeptide binding]; other site
290397004961	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
290397004962	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
290397004963	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
290397004964	PAS domain; Region: PAS; smart00091
290397004965	PAS domain; Region: PAS_9; pfam13426
290397004966	putative active site [active]
290397004967	heme pocket [chemical binding]; other site
290397004968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397004969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397004970	dimer interface [polypeptide binding]; other site
290397004971	phosphorylation site [posttranslational modification]
290397004972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397004973	ATP binding site [chemical binding]; other site
290397004974	Mg2+ binding site [ion binding]; other site
290397004975	G-X-G motif; other site
290397004976	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
290397004977	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
290397004978	active site
290397004979	catalytic residues [active]
290397004980	Domain of unknown function DUF59; Region: DUF59; pfam01883
290397004981	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
290397004982	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
290397004983	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
290397004984	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
290397004985	oligomer interface [polypeptide binding]; other site
290397004986	metal binding site [ion binding]; metal-binding site
290397004987	metal binding site [ion binding]; metal-binding site
290397004988	putative Cl binding site [ion binding]; other site
290397004989	aspartate ring; other site
290397004990	basic sphincter; other site
290397004991	hydrophobic gate; other site
290397004992	periplasmic entrance; other site
290397004993	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
290397004994	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
290397004995	putative active site [active]
290397004996	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290397004997	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
290397004998	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290397004999	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
290397005000	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397005001	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397005002	DNA binding residues [nucleotide binding]
290397005003	Secretin and TonB N terminus short domain; Region: STN; pfam07660
290397005004	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
290397005005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397005006	RNA binding surface [nucleotide binding]; other site
290397005007	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
290397005008	active site
290397005009	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
290397005010	ScpA/B protein; Region: ScpA_ScpB; cl00598
290397005011	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
290397005012	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
290397005013	active site
290397005014	HIGH motif; other site
290397005015	dimer interface [polypeptide binding]; other site
290397005016	KMSKS motif; other site
290397005017	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
290397005018	Peptidase family M50; Region: Peptidase_M50; pfam02163
290397005019	active site
290397005020	putative substrate binding region [chemical binding]; other site
290397005021	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
290397005022	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
290397005023	active site
290397005024	Int/Topo IB signature motif; other site
290397005025	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
290397005026	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
290397005027	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397005028	PII uridylyl-transferase; Provisional; Region: PRK05092
290397005029	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397005030	metal binding triad; other site
290397005031	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
290397005032	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397005033	Zn2+ binding site [ion binding]; other site
290397005034	Mg2+ binding site [ion binding]; other site
290397005035	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
290397005036	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
290397005037	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
290397005038	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397005039	protein binding site [polypeptide binding]; other site
290397005040	AMIN domain; Region: AMIN; pfam11741
290397005041	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
290397005042	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
290397005043	active site
290397005044	metal binding site [ion binding]; metal-binding site
290397005045	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
290397005046	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
290397005047	conserved cys residue [active]
290397005048	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
290397005049	heme-binding residues [chemical binding]; other site
290397005050	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
290397005051	heme-binding residues [chemical binding]; other site
290397005052	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
290397005053	MutS domain I; Region: MutS_I; pfam01624
290397005054	MutS domain III; Region: MutS_III; pfam05192
290397005055	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
290397005056	Walker A/P-loop; other site
290397005057	ATP binding site [chemical binding]; other site
290397005058	Q-loop/lid; other site
290397005059	ABC transporter signature motif; other site
290397005060	Walker B; other site
290397005061	D-loop; other site
290397005062	H-loop/switch region; other site
290397005063	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
290397005064	ABC1 family; Region: ABC1; cl17513
290397005065	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
290397005066	active site
290397005067	ATP binding site [chemical binding]; other site
290397005068	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
290397005069	LexA repressor; Validated; Region: PRK00215
290397005070	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
290397005071	Catalytic site [active]
290397005072	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290397005073	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290397005074	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290397005075	Found in ATP-dependent protease La (LON); Region: LON; smart00464
290397005076	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
290397005077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005078	Walker A motif; other site
290397005079	ATP binding site [chemical binding]; other site
290397005080	Walker B motif; other site
290397005081	arginine finger; other site
290397005082	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
290397005083	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397005084	active site
290397005085	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397005086	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397005087	active site
290397005088	ATP binding site [chemical binding]; other site
290397005089	substrate binding site [chemical binding]; other site
290397005090	activation loop (A-loop); other site
290397005091	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397005092	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
290397005093	phosphopeptide binding site; other site
290397005094	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
290397005095	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397005096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005097	Walker A motif; other site
290397005098	ATP binding site [chemical binding]; other site
290397005099	Walker B motif; other site
290397005100	arginine finger; other site
290397005101	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005102	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
290397005103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005104	ATP binding site [chemical binding]; other site
290397005105	Mg2+ binding site [ion binding]; other site
290397005106	G-X-G motif; other site
290397005107	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
290397005108	ATP binding site [chemical binding]; other site
290397005109	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
290397005110	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397005111	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
290397005112	putative acyl-acceptor binding pocket; other site
290397005113	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
290397005114	Di-iron ligands [ion binding]; other site
290397005115	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
290397005116	Cytochrome c; Region: Cytochrom_C; pfam00034
290397005117	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
290397005118	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
290397005119	putative MPT binding site; other site
290397005120	thymidylate kinase; Region: DTMP_kinase; TIGR00041
290397005121	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
290397005122	TMP-binding site; other site
290397005123	ATP-binding site [chemical binding]; other site
290397005124	threonine synthase; Region: PLN02569
290397005125	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
290397005126	homodimer interface [polypeptide binding]; other site
290397005127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397005128	catalytic residue [active]
290397005129	aminotransferase; Validated; Region: PRK08175
290397005130	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397005131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397005132	homodimer interface [polypeptide binding]; other site
290397005133	catalytic residue [active]
290397005134	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
290397005135	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
290397005136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397005137	S-adenosylmethionine binding site [chemical binding]; other site
290397005138	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
290397005139	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
290397005140	generic binding surface II; other site
290397005141	ssDNA binding site; other site
290397005142	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397005143	ATP binding site [chemical binding]; other site
290397005144	putative Mg++ binding site [ion binding]; other site
290397005145	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397005146	nucleotide binding region [chemical binding]; other site
290397005147	ATP-binding site [chemical binding]; other site
290397005148	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
290397005149	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
290397005150	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290397005151	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
290397005152	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397005153	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
290397005154	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290397005155	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397005156	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397005157	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
290397005158	IMP binding site; other site
290397005159	dimer interface [polypeptide binding]; other site
290397005160	partial ornithine binding site; other site
290397005161	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397005162	aspartate aminotransferase; Provisional; Region: PRK05764
290397005163	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397005164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397005165	homodimer interface [polypeptide binding]; other site
290397005166	catalytic residue [active]
290397005167	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
290397005168	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
290397005169	active site
290397005170	(T/H)XGH motif; other site
290397005171	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
290397005172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397005173	S-adenosylmethionine binding site [chemical binding]; other site
290397005174	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
290397005175	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290397005176	Serine hydrolase; Region: Ser_hydrolase; cl17834
290397005177	TAP-like protein; Region: Abhydrolase_4; pfam08386
290397005178	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397005179	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397005180	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397005181	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397005182	active site
290397005183	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
290397005184	active site
290397005185	NTP binding site [chemical binding]; other site
290397005186	metal binding triad [ion binding]; metal-binding site
290397005187	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397005188	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397005189	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
290397005190	active site
290397005191	RNA polymerase sigma factor; Provisional; Region: PRK11924
290397005192	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397005193	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397005194	DNA binding residues [nucleotide binding]
290397005195	OsmC-like protein; Region: OsmC; cl00767
290397005196	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
290397005197	Beta-lactamase; Region: Beta-lactamase; pfam00144
290397005198	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
290397005199	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
290397005200	RES domain; Region: RES; cl02411
290397005201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397005202	Coenzyme A binding pocket [chemical binding]; other site
290397005203	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
290397005204	heme-binding site [chemical binding]; other site
290397005205	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
290397005206	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
290397005207	trimer interface [polypeptide binding]; other site
290397005208	eyelet of channel; other site
290397005209	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
290397005210	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
290397005211	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
290397005212	Aspartase; Region: Aspartase; cd01357
290397005213	active sites [active]
290397005214	tetramer interface [polypeptide binding]; other site
290397005215	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397005216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005217	active site
290397005218	phosphorylation site [posttranslational modification]
290397005219	intermolecular recognition site; other site
290397005220	dimerization interface [polypeptide binding]; other site
290397005221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005222	Walker A motif; other site
290397005223	ATP binding site [chemical binding]; other site
290397005224	Walker B motif; other site
290397005225	arginine finger; other site
290397005226	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005227	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
290397005228	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290397005229	substrate binding pocket [chemical binding]; other site
290397005230	membrane-bound complex binding site; other site
290397005231	hinge residues; other site
290397005232	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397005233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005234	ATP binding site [chemical binding]; other site
290397005235	Mg2+ binding site [ion binding]; other site
290397005236	G-X-G motif; other site
290397005237	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
290397005238	gating phenylalanine in ion channel; other site
290397005239	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397005240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005241	active site
290397005242	phosphorylation site [posttranslational modification]
290397005243	intermolecular recognition site; other site
290397005244	dimerization interface [polypeptide binding]; other site
290397005245	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397005246	DNA binding residues [nucleotide binding]
290397005247	dimerization interface [polypeptide binding]; other site
290397005248	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397005249	dimerization interface [polypeptide binding]; other site
290397005250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
290397005251	Histidine kinase; Region: HisKA_3; pfam07730
290397005252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005253	ATP binding site [chemical binding]; other site
290397005254	Mg2+ binding site [ion binding]; other site
290397005255	G-X-G motif; other site
290397005256	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
290397005257	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
290397005258	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
290397005259	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
290397005260	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
290397005261	NAD(P) binding site [chemical binding]; other site
290397005262	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
290397005263	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397005264	Walker A/P-loop; other site
290397005265	ATP binding site [chemical binding]; other site
290397005266	Q-loop/lid; other site
290397005267	ABC transporter signature motif; other site
290397005268	Walker B; other site
290397005269	D-loop; other site
290397005270	H-loop/switch region; other site
290397005271	PilZ domain; Region: PilZ; cl01260
290397005272	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
290397005273	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397005274	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397005275	protein binding site [polypeptide binding]; other site
290397005276	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290397005277	protein binding site [polypeptide binding]; other site
290397005278	GrpE; Region: GrpE; pfam01025
290397005279	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
290397005280	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
290397005281	FtsH Extracellular; Region: FtsH_ext; pfam06480
290397005282	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290397005283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005284	Walker A motif; other site
290397005285	ATP binding site [chemical binding]; other site
290397005286	Walker B motif; other site
290397005287	arginine finger; other site
290397005288	Peptidase family M41; Region: Peptidase_M41; pfam01434
290397005289	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
290397005290	active site
290397005291	8-oxo-dGMP binding site [chemical binding]; other site
290397005292	nudix motif; other site
290397005293	metal binding site [ion binding]; metal-binding site
290397005294	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
290397005295	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397005296	Beta-Casp domain; Region: Beta-Casp; smart01027
290397005297	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
290397005298	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290397005299	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
290397005300	active site
290397005301	nucleophile elbow; other site
290397005302	prephenate dehydratase; Provisional; Region: PRK11898
290397005303	Prephenate dehydratase; Region: PDT; pfam00800
290397005304	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
290397005305	putative L-Phe binding site [chemical binding]; other site
290397005306	pyrophosphatase PpaX; Provisional; Region: PRK13288
290397005307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397005308	active site
290397005309	motif I; other site
290397005310	motif II; other site
290397005311	PAS fold; Region: PAS_4; pfam08448
290397005312	PAS domain; Region: PAS; smart00091
290397005313	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397005314	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397005315	dimer interface [polypeptide binding]; other site
290397005316	phosphorylation site [posttranslational modification]
290397005317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005318	ATP binding site [chemical binding]; other site
290397005319	Mg2+ binding site [ion binding]; other site
290397005320	G-X-G motif; other site
290397005321	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
290397005322	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397005323	AAA domain; Region: AAA_25; pfam13481
290397005324	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397005325	Walker A motif; other site
290397005326	Walker A motif; other site
290397005327	ATP binding site [chemical binding]; other site
290397005328	Walker B motif; other site
290397005329	Terminase small subunit; Region: Terminase_2; pfam03592
290397005330	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
290397005331	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397005332	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
290397005333	nucleotide binding site [chemical binding]; other site
290397005334	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
290397005335	Part of AAA domain; Region: AAA_19; pfam13245
290397005336	Family description; Region: UvrD_C_2; pfam13538
290397005337	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
290397005338	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
290397005339	active site
290397005340	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
290397005341	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290397005342	DXD motif; other site
290397005343	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
290397005344	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
290397005345	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
290397005346	active sites [active]
290397005347	tetramer interface [polypeptide binding]; other site
290397005348	aspartate kinase; Validated; Region: PRK09181
290397005349	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
290397005350	nucleotide binding site [chemical binding]; other site
290397005351	substrate binding site [chemical binding]; other site
290397005352	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290397005353	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290397005354	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397005355	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397005356	phosphopeptide binding site; other site
290397005357	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290397005358	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290397005359	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397005360	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397005361	active site
290397005362	ATP binding site [chemical binding]; other site
290397005363	substrate binding site [chemical binding]; other site
290397005364	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397005365	substrate binding site [chemical binding]; other site
290397005366	activation loop (A-loop); other site
290397005367	activation loop (A-loop); other site
290397005368	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397005369	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397005370	active site
290397005371	ATP binding site [chemical binding]; other site
290397005372	substrate binding site [chemical binding]; other site
290397005373	activation loop (A-loop); other site
290397005374	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
290397005375	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
290397005376	nudix motif; other site
290397005377	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
290397005378	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
290397005379	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397005380	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290397005381	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
290397005382	putative ATP binding site [chemical binding]; other site
290397005383	putative substrate interface [chemical binding]; other site
290397005384	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
290397005385	active site
290397005386	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
290397005387	E3 interaction surface; other site
290397005388	lipoyl attachment site [posttranslational modification]; other site
290397005389	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
290397005390	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
290397005391	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
290397005392	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
290397005393	alpha subunit interface [polypeptide binding]; other site
290397005394	TPP binding site [chemical binding]; other site
290397005395	heterodimer interface [polypeptide binding]; other site
290397005396	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290397005397	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
290397005398	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
290397005399	TPP-binding site [chemical binding]; other site
290397005400	tetramer interface [polypeptide binding]; other site
290397005401	heterodimer interface [polypeptide binding]; other site
290397005402	phosphorylation loop region [posttranslational modification]
290397005403	lipoyl synthase; Provisional; Region: PRK05481
290397005404	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397005405	FeS/SAM binding site; other site
290397005406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005407	active site
290397005408	phosphorylation site [posttranslational modification]
290397005409	intermolecular recognition site; other site
290397005410	dimerization interface [polypeptide binding]; other site
290397005411	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397005412	Zn2+ binding site [ion binding]; other site
290397005413	Mg2+ binding site [ion binding]; other site
290397005414	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
290397005415	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397005416	FeS/SAM binding site; other site
290397005417	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
290397005418	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
290397005419	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
290397005420	B12 binding site [chemical binding]; other site
290397005421	cobalt ligand [ion binding]; other site
290397005422	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
290397005423	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
290397005424	Int/Topo IB signature motif; other site
290397005425	DNA binding site [nucleotide binding]
290397005426	active site
290397005427	Uncharacterized conserved protein [Function unknown]; Region: COG4983
290397005428	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
290397005429	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
290397005430	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
290397005431	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
290397005432	T5orf172 domain; Region: T5orf172; pfam10544
290397005433	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
290397005434	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
290397005435	enoyl-CoA hydratase; Validated; Region: PRK08139
290397005436	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397005437	substrate binding site [chemical binding]; other site
290397005438	oxyanion hole (OAH) forming residues; other site
290397005439	trimer interface [polypeptide binding]; other site
290397005440	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
290397005441	Beta propeller domain; Region: Beta_propel; pfam09826
290397005442	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290397005443	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
290397005444	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
290397005445	dimerization interface [polypeptide binding]; other site
290397005446	ligand binding site [chemical binding]; other site
290397005447	NADP binding site [chemical binding]; other site
290397005448	catalytic site [active]
290397005449	Domain of unknown function (DUF329); Region: DUF329; pfam03884
290397005450	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290397005451	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397005452	catalytic residues [active]
290397005453	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
290397005454	mce related protein; Region: MCE; pfam02470
290397005455	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
290397005456	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
290397005457	Walker A/P-loop; other site
290397005458	ATP binding site [chemical binding]; other site
290397005459	Q-loop/lid; other site
290397005460	ABC transporter signature motif; other site
290397005461	Walker B; other site
290397005462	D-loop; other site
290397005463	H-loop/switch region; other site
290397005464	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
290397005465	Permease; Region: Permease; pfam02405
290397005466	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397005467	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397005468	active site
290397005469	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397005470	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397005471	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397005472	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397005473	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397005474	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397005475	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397005476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397005477	sequence-specific DNA binding site [nucleotide binding]; other site
290397005478	salt bridge; other site
290397005479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397005480	active site
290397005481	motif I; other site
290397005482	motif II; other site
290397005483	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
290397005484	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
290397005485	DNA binding site [nucleotide binding]
290397005486	AAA domain; Region: AAA_25; pfam13481
290397005487	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397005488	Walker A motif; other site
290397005489	ATP binding site [chemical binding]; other site
290397005490	Walker B motif; other site
290397005491	Helix-turn-helix domain; Region: HTH_17; pfam12728
290397005492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397005493	non-specific DNA binding site [nucleotide binding]; other site
290397005494	salt bridge; other site
290397005495	sequence-specific DNA binding site [nucleotide binding]; other site
290397005496	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
290397005497	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
290397005498	heme-binding residues [chemical binding]; other site
290397005499	methionine sulfoxide reductase A; Provisional; Region: PRK00058
290397005500	Dodecin; Region: Dodecin; pfam07311
290397005501	arginine decarboxylase; Provisional; Region: PRK05354
290397005502	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
290397005503	active site
290397005504	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290397005505	catalytic residues [active]
290397005506	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
290397005507	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290397005508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397005509	Walker A/P-loop; other site
290397005510	ATP binding site [chemical binding]; other site
290397005511	Q-loop/lid; other site
290397005512	ABC transporter signature motif; other site
290397005513	Walker B; other site
290397005514	D-loop; other site
290397005515	H-loop/switch region; other site
290397005516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397005517	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397005518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397005519	binding surface
290397005520	TPR motif; other site
290397005521	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397005522	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397005523	RNA binding surface [nucleotide binding]; other site
290397005524	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397005525	active site
290397005526	DnaJ domain; Region: DnaJ; pfam00226
290397005527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397005528	non-specific DNA binding site [nucleotide binding]; other site
290397005529	salt bridge; other site
290397005530	sequence-specific DNA binding site [nucleotide binding]; other site
290397005531	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
290397005532	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397005533	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397005534	active site
290397005535	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397005536	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397005537	catalytic residue [active]
290397005538	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397005539	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397005540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397005541	dimer interface [polypeptide binding]; other site
290397005542	phosphorylation site [posttranslational modification]
290397005543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005544	ATP binding site [chemical binding]; other site
290397005545	Mg2+ binding site [ion binding]; other site
290397005546	G-X-G motif; other site
290397005547	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397005548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005549	active site
290397005550	phosphorylation site [posttranslational modification]
290397005551	intermolecular recognition site; other site
290397005552	dimerization interface [polypeptide binding]; other site
290397005553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005554	Walker A motif; other site
290397005555	ATP binding site [chemical binding]; other site
290397005556	Walker B motif; other site
290397005557	arginine finger; other site
290397005558	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005559	Predicted methyltransferases [General function prediction only]; Region: COG0313
290397005560	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
290397005561	putative SAM binding site [chemical binding]; other site
290397005562	putative homodimer interface [polypeptide binding]; other site
290397005563	hypothetical protein; Reviewed; Region: PRK12497
290397005564	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
290397005565	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
290397005566	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
290397005567	RimM N-terminal domain; Region: RimM; pfam01782
290397005568	PRC-barrel domain; Region: PRC; pfam05239
290397005569	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
290397005570	KH domain; Region: KH_4; pfam13083
290397005571	G-X-X-G motif; other site
290397005572	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14525
290397005573	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
290397005574	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
290397005575	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
290397005576	alphaNTD homodimer interface [polypeptide binding]; other site
290397005577	alphaNTD - beta interaction site [polypeptide binding]; other site
290397005578	alphaNTD - beta' interaction site [polypeptide binding]; other site
290397005579	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
290397005580	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
290397005581	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
290397005582	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290397005583	RNA binding surface [nucleotide binding]; other site
290397005584	30S ribosomal protein S11; Validated; Region: PRK05309
290397005585	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
290397005586	30S ribosomal protein S13; Region: bact_S13; TIGR03631
290397005587	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
290397005588	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
290397005589	active site
290397005590	adenylate kinase; Reviewed; Region: adk; PRK00279
290397005591	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
290397005592	AMP-binding site [chemical binding]; other site
290397005593	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
290397005594	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
290397005595	SecY translocase; Region: SecY; pfam00344
290397005596	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
290397005597	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
290397005598	23S rRNA binding site [nucleotide binding]; other site
290397005599	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
290397005600	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
290397005601	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
290397005602	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
290397005603	5S rRNA interface [nucleotide binding]; other site
290397005604	L27 interface [polypeptide binding]; other site
290397005605	L5 interface [polypeptide binding]; other site
290397005606	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
290397005607	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
290397005608	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
290397005609	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
290397005610	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
290397005611	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
290397005612	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
290397005613	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
290397005614	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
290397005615	RNA binding site [nucleotide binding]; other site
290397005616	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
290397005617	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
290397005618	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
290397005619	23S rRNA interface [nucleotide binding]; other site
290397005620	putative translocon interaction site; other site
290397005621	signal recognition particle (SRP54) interaction site; other site
290397005622	L23 interface [polypeptide binding]; other site
290397005623	trigger factor interaction site; other site
290397005624	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
290397005625	23S rRNA interface [nucleotide binding]; other site
290397005626	5S rRNA interface [nucleotide binding]; other site
290397005627	putative antibiotic binding site [chemical binding]; other site
290397005628	L25 interface [polypeptide binding]; other site
290397005629	L27 interface [polypeptide binding]; other site
290397005630	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
290397005631	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
290397005632	G-X-X-G motif; other site
290397005633	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
290397005634	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
290397005635	protein-rRNA interface [nucleotide binding]; other site
290397005636	putative translocon binding site; other site
290397005637	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
290397005638	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
290397005639	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
290397005640	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
290397005641	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
290397005642	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
290397005643	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
290397005644	elongation factor Tu; Reviewed; Region: PRK00049
290397005645	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
290397005646	G1 box; other site
290397005647	GEF interaction site [polypeptide binding]; other site
290397005648	GTP/Mg2+ binding site [chemical binding]; other site
290397005649	Switch I region; other site
290397005650	G2 box; other site
290397005651	G3 box; other site
290397005652	Switch II region; other site
290397005653	G4 box; other site
290397005654	G5 box; other site
290397005655	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
290397005656	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
290397005657	Antibiotic Binding Site [chemical binding]; other site
290397005658	elongation factor G; Reviewed; Region: PRK00007
290397005659	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
290397005660	G1 box; other site
290397005661	putative GEF interaction site [polypeptide binding]; other site
290397005662	GTP/Mg2+ binding site [chemical binding]; other site
290397005663	Switch I region; other site
290397005664	G2 box; other site
290397005665	G3 box; other site
290397005666	Switch II region; other site
290397005667	G4 box; other site
290397005668	G5 box; other site
290397005669	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290397005670	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290397005671	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290397005672	30S ribosomal protein S7; Validated; Region: PRK05302
290397005673	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
290397005674	S17 interaction site [polypeptide binding]; other site
290397005675	S8 interaction site; other site
290397005676	16S rRNA interaction site [nucleotide binding]; other site
290397005677	streptomycin interaction site [chemical binding]; other site
290397005678	23S rRNA interaction site [nucleotide binding]; other site
290397005679	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
290397005680	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290397005681	minor groove reading motif; other site
290397005682	helix-hairpin-helix signature motif; other site
290397005683	substrate binding pocket [chemical binding]; other site
290397005684	active site
290397005685	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
290397005686	Transglycosylase; Region: Transgly; pfam00912
290397005687	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397005688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397005689	NAD(P) binding site [chemical binding]; other site
290397005690	active site
290397005691	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
290397005692	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397005693	NAD binding site [chemical binding]; other site
290397005694	putative substrate binding site 2 [chemical binding]; other site
290397005695	putative substrate binding site 1 [chemical binding]; other site
290397005696	active site
290397005697	TPR repeat; Region: TPR_11; pfam13414
290397005698	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397005699	binding surface
290397005700	TPR motif; other site
290397005701	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290397005702	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
290397005703	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290397005704	TPP-binding site [chemical binding]; other site
290397005705	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
290397005706	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290397005707	dimer interface [polypeptide binding]; other site
290397005708	PYR/PP interface [polypeptide binding]; other site
290397005709	TPP binding site [chemical binding]; other site
290397005710	substrate binding site [chemical binding]; other site
290397005711	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290397005712	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
290397005713	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290397005714	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
290397005715	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290397005716	TPP-binding site [chemical binding]; other site
290397005717	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290397005718	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
290397005719	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290397005720	dimer interface [polypeptide binding]; other site
290397005721	PYR/PP interface [polypeptide binding]; other site
290397005722	TPP binding site [chemical binding]; other site
290397005723	substrate binding site [chemical binding]; other site
290397005724	FAD binding domain; Region: FAD_binding_4; pfam01565
290397005725	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
290397005726	classical (c) SDRs; Region: SDR_c; cd05233
290397005727	NAD(P) binding site [chemical binding]; other site
290397005728	active site
290397005729	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
290397005730	active site
290397005731	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
290397005732	active site
290397005733	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
290397005734	iron-sulfur cluster [ion binding]; other site
290397005735	[2Fe-2S] cluster binding site [ion binding]; other site
290397005736	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005737	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290397005738	IHF dimer interface [polypeptide binding]; other site
290397005739	IHF - DNA interface [nucleotide binding]; other site
290397005740	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
290397005741	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
290397005742	putative tRNA-binding site [nucleotide binding]; other site
290397005743	B3/4 domain; Region: B3_4; pfam03483
290397005744	tRNA synthetase B5 domain; Region: B5; smart00874
290397005745	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290397005746	dimer interface [polypeptide binding]; other site
290397005747	active site
290397005748	motif 2; other site
290397005749	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
290397005750	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
290397005751	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
290397005752	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
290397005753	dimer interface [polypeptide binding]; other site
290397005754	motif 1; other site
290397005755	active site
290397005756	motif 2; other site
290397005757	motif 3; other site
290397005758	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
290397005759	23S rRNA binding site [nucleotide binding]; other site
290397005760	L21 binding site [polypeptide binding]; other site
290397005761	L13 binding site [polypeptide binding]; other site
290397005762	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
290397005763	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
290397005764	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
290397005765	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
290397005766	ketol-acid reductoisomerase; Provisional; Region: PRK05479
290397005767	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
290397005768	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
290397005769	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
290397005770	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
290397005771	putative valine binding site [chemical binding]; other site
290397005772	dimer interface [polypeptide binding]; other site
290397005773	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
290397005774	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
290397005775	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
290397005776	PYR/PP interface [polypeptide binding]; other site
290397005777	dimer interface [polypeptide binding]; other site
290397005778	TPP binding site [chemical binding]; other site
290397005779	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290397005780	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
290397005781	TPP-binding site [chemical binding]; other site
290397005782	dimer interface [polypeptide binding]; other site
290397005783	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
290397005784	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
290397005785	substrate binding site [chemical binding]; other site
290397005786	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
290397005787	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
290397005788	substrate binding site [chemical binding]; other site
290397005789	ligand binding site [chemical binding]; other site
290397005790	2-isopropylmalate synthase; Validated; Region: PRK00915
290397005791	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
290397005792	active site
290397005793	catalytic residues [active]
290397005794	metal binding site [ion binding]; metal-binding site
290397005795	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
290397005796	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
290397005797	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
290397005798	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
290397005799	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
290397005800	active site
290397005801	dimer interface [polypeptide binding]; other site
290397005802	motif 1; other site
290397005803	motif 2; other site
290397005804	motif 3; other site
290397005805	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
290397005806	anticodon binding site; other site
290397005807	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
290397005808	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290397005809	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397005810	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
290397005811	active site
290397005812	metal binding site [ion binding]; metal-binding site
290397005813	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397005814	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
290397005815	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
290397005816	G1 box; other site
290397005817	putative GEF interaction site [polypeptide binding]; other site
290397005818	GTP/Mg2+ binding site [chemical binding]; other site
290397005819	Switch I region; other site
290397005820	G2 box; other site
290397005821	G3 box; other site
290397005822	Switch II region; other site
290397005823	G4 box; other site
290397005824	G5 box; other site
290397005825	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
290397005826	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
290397005827	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
290397005828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005829	Response regulator receiver domain; Region: Response_reg; pfam00072
290397005830	active site
290397005831	phosphorylation site [posttranslational modification]
290397005832	intermolecular recognition site; other site
290397005833	dimerization interface [polypeptide binding]; other site
290397005834	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
290397005835	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290397005836	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397005837	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397005838	DNA binding residues [nucleotide binding]
290397005839	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397005840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005841	active site
290397005842	phosphorylation site [posttranslational modification]
290397005843	intermolecular recognition site; other site
290397005844	dimerization interface [polypeptide binding]; other site
290397005845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005846	Walker A motif; other site
290397005847	ATP binding site [chemical binding]; other site
290397005848	Walker B motif; other site
290397005849	arginine finger; other site
290397005850	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005851	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397005852	dimerization interface [polypeptide binding]; other site
290397005853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397005854	dimer interface [polypeptide binding]; other site
290397005855	phosphorylation site [posttranslational modification]
290397005856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005857	ATP binding site [chemical binding]; other site
290397005858	Mg2+ binding site [ion binding]; other site
290397005859	G-X-G motif; other site
290397005860	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
290397005861	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
290397005862	NAD(P) binding pocket [chemical binding]; other site
290397005863	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
290397005864	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397005865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005866	active site
290397005867	phosphorylation site [posttranslational modification]
290397005868	intermolecular recognition site; other site
290397005869	dimerization interface [polypeptide binding]; other site
290397005870	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397005871	DNA binding residues [nucleotide binding]
290397005872	dimerization interface [polypeptide binding]; other site
290397005873	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397005874	dimerization interface [polypeptide binding]; other site
290397005875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
290397005876	Histidine kinase; Region: HisKA_3; pfam07730
290397005877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005878	ATP binding site [chemical binding]; other site
290397005879	Mg2+ binding site [ion binding]; other site
290397005880	G-X-G motif; other site
290397005881	Peptidase family M48; Region: Peptidase_M48; cl12018
290397005882	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290397005883	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290397005884	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
290397005885	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397005886	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
290397005887	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
290397005888	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290397005889	lipoyl attachment site [posttranslational modification]; other site
290397005890	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
290397005891	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290397005892	lipoyl attachment site [posttranslational modification]; other site
290397005893	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290397005894	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
290397005895	4Fe-4S binding domain; Region: Fer4; pfam00037
290397005896	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397005897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397005898	active site
290397005899	phosphorylation site [posttranslational modification]
290397005900	intermolecular recognition site; other site
290397005901	dimerization interface [polypeptide binding]; other site
290397005902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397005903	Walker A motif; other site
290397005904	ATP binding site [chemical binding]; other site
290397005905	Walker B motif; other site
290397005906	arginine finger; other site
290397005907	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397005908	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
290397005909	active site
290397005910	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397005911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397005912	dimerization interface [polypeptide binding]; other site
290397005913	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397005914	dimer interface [polypeptide binding]; other site
290397005915	phosphorylation site [posttranslational modification]
290397005916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397005917	ATP binding site [chemical binding]; other site
290397005918	Mg2+ binding site [ion binding]; other site
290397005919	G-X-G motif; other site
290397005920	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
290397005921	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
290397005922	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
290397005923	putative active site [active]
290397005924	putative substrate binding site [chemical binding]; other site
290397005925	putative cosubstrate binding site; other site
290397005926	catalytic site [active]
290397005927	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
290397005928	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
290397005929	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
290397005930	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
290397005931	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
290397005932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397005933	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
290397005934	putative dimerization interface [polypeptide binding]; other site
290397005935	Peptidase family M48; Region: Peptidase_M48; cl12018
290397005936	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
290397005937	GSH binding site [chemical binding]; other site
290397005938	catalytic residues [active]
290397005939	Outer membrane efflux protein; Region: OEP; pfam02321
290397005940	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397005941	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397005942	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397005943	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397005944	Protein export membrane protein; Region: SecD_SecF; cl14618
290397005945	CsbD-like; Region: CsbD; pfam05532
290397005946	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
290397005947	active site
290397005948	Zn binding site [ion binding]; other site
290397005949	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
290397005950	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397005951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397005952	NAD(P) binding site [chemical binding]; other site
290397005953	active site
290397005954	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397005955	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397005956	active site
290397005957	catalytic tetrad [active]
290397005958	phosphoglucomutase; Validated; Region: PRK07564
290397005959	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
290397005960	active site
290397005961	substrate binding site [chemical binding]; other site
290397005962	metal binding site [ion binding]; metal-binding site
290397005963	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
290397005964	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
290397005965	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
290397005966	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290397005967	DXD motif; other site
290397005968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397005969	binding surface
290397005970	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397005971	TPR motif; other site
290397005972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397005973	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397005974	Protein of unknown function (DUF3115); Region: DUF3115; pfam11312
290397005975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397005976	S-adenosylmethionine binding site [chemical binding]; other site
290397005977	Stage II sporulation protein; Region: SpoIID; pfam08486
290397005978	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
290397005979	Transglycosylase; Region: Transgly; pfam00912
290397005980	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
290397005981	Bacterial Ig-like domain; Region: Big_5; pfam13205
290397005982	Bacterial Ig-like domain; Region: Big_5; pfam13205
290397005983	MG2 domain; Region: A2M_N; pfam01835
290397005984	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
290397005985	Alpha-2-macroglobulin family; Region: A2M; pfam00207
290397005986	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
290397005987	surface patch; other site
290397005988	thioester region; other site
290397005989	specificity defining residues; other site
290397005990	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
290397005991	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
290397005992	HDOD domain; Region: HDOD; pfam08668
290397005993	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
290397005994	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397005995	FtsX-like permease family; Region: FtsX; pfam02687
290397005996	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397005997	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397005998	Walker A/P-loop; other site
290397005999	ATP binding site [chemical binding]; other site
290397006000	Q-loop/lid; other site
290397006001	ABC transporter signature motif; other site
290397006002	Walker B; other site
290397006003	D-loop; other site
290397006004	H-loop/switch region; other site
290397006005	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
290397006006	active site
290397006007	catalytic triad [active]
290397006008	oxyanion hole [active]
290397006009	MarC family integral membrane protein; Region: MarC; cl00919
290397006010	acetyl-CoA synthetase; Provisional; Region: PRK00174
290397006011	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397006012	acyl-activating enzyme (AAE) consensus motif; other site
290397006013	AMP binding site [chemical binding]; other site
290397006014	active site
290397006015	CoA binding site [chemical binding]; other site
290397006016	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
290397006017	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
290397006018	active site
290397006019	catalytic site [active]
290397006020	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
290397006021	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
290397006022	dimer interface [polypeptide binding]; other site
290397006023	substrate binding site [chemical binding]; other site
290397006024	ATP binding site [chemical binding]; other site
290397006025	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
290397006026	ATP-grasp domain; Region: ATP-grasp; pfam02222
290397006027	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
290397006028	oligoendopeptidase F; Region: pepF; TIGR00181
290397006029	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
290397006030	active site
290397006031	Zn binding site [ion binding]; other site
290397006032	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
290397006033	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
290397006034	putative active site [active]
290397006035	catalytic site [active]
290397006036	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
290397006037	putative active site [active]
290397006038	catalytic site [active]
290397006039	DTW domain; Region: DTW; cl01221
290397006040	elongation factor G; Reviewed; Region: PRK12739
290397006041	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290397006042	G1 box; other site
290397006043	GTP/Mg2+ binding site [chemical binding]; other site
290397006044	G2 box; other site
290397006045	Switch I region; other site
290397006046	G3 box; other site
290397006047	Switch II region; other site
290397006048	G4 box; other site
290397006049	G5 box; other site
290397006050	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290397006051	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
290397006052	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290397006053	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290397006054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397006055	Walker A/P-loop; other site
290397006056	ATP binding site [chemical binding]; other site
290397006057	Q-loop/lid; other site
290397006058	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397006059	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397006060	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
290397006061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
290397006062	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
290397006063	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
290397006064	fumarate hydratase; Provisional; Region: PRK15389
290397006065	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
290397006066	Fumarase C-terminus; Region: Fumerase_C; pfam05683
290397006067	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
290397006068	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
290397006069	tartrate dehydrogenase; Region: TTC; TIGR02089
290397006070	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
290397006071	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
290397006072	active site
290397006073	catalytic residues [active]
290397006074	metal binding site [ion binding]; metal-binding site
290397006075	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290397006076	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
290397006077	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
290397006078	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290397006079	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
290397006080	diiron binding motif [ion binding]; other site
290397006081	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397006082	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397006083	active site
290397006084	catalytic tetrad [active]
290397006085	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
290397006086	RNA/DNA hybrid binding site [nucleotide binding]; other site
290397006087	active site
290397006088	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397006089	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290397006090	putative acyl-acceptor binding pocket; other site
290397006091	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
290397006092	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
290397006093	metal binding site [ion binding]; metal-binding site
290397006094	dimer interface [polypeptide binding]; other site
290397006095	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
290397006096	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
290397006097	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
290397006098	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
290397006099	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397006100	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397006101	catalytic residue [active]
290397006102	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290397006103	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
290397006104	active site
290397006105	ADP/pyrophosphate binding site [chemical binding]; other site
290397006106	dimerization interface [polypeptide binding]; other site
290397006107	allosteric effector site; other site
290397006108	fructose-1,6-bisphosphate binding site; other site
290397006109	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
290397006110	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
290397006111	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
290397006112	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290397006113	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290397006114	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006115	molybdopterin cofactor binding site; other site
290397006116	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006117	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
290397006118	molybdopterin cofactor binding site; other site
290397006119	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006120	CHASE domain; Region: CHASE; pfam03924
290397006121	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397006122	GAF domain; Region: GAF; pfam01590
290397006123	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397006124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397006125	dimer interface [polypeptide binding]; other site
290397006126	phosphorylation site [posttranslational modification]
290397006127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397006128	ATP binding site [chemical binding]; other site
290397006129	Mg2+ binding site [ion binding]; other site
290397006130	G-X-G motif; other site
290397006131	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
290397006132	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
290397006133	putative DNA binding site [nucleotide binding]; other site
290397006134	catalytic residue [active]
290397006135	putative H2TH interface [polypeptide binding]; other site
290397006136	putative catalytic residues [active]
290397006137	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
290397006138	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397006139	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
290397006140	ATP binding site [chemical binding]; other site
290397006141	putative Mg++ binding site [ion binding]; other site
290397006142	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397006143	nucleotide binding region [chemical binding]; other site
290397006144	ATP-binding site [chemical binding]; other site
290397006145	DEAD/H associated; Region: DEAD_assoc; pfam08494
290397006146	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290397006147	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
290397006148	substrate-cofactor binding pocket; other site
290397006149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397006150	catalytic residue [active]
290397006151	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
290397006152	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
290397006153	NAD(P) binding site [chemical binding]; other site
290397006154	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
290397006155	L-aspartate oxidase; Provisional; Region: PRK06175
290397006156	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
290397006157	active site
290397006158	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
290397006159	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
290397006160	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397006161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006162	active site
290397006163	phosphorylation site [posttranslational modification]
290397006164	intermolecular recognition site; other site
290397006165	dimerization interface [polypeptide binding]; other site
290397006166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006167	Walker A motif; other site
290397006168	ATP binding site [chemical binding]; other site
290397006169	Walker B motif; other site
290397006170	arginine finger; other site
290397006171	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397006172	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
290397006173	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290397006174	substrate binding pocket [chemical binding]; other site
290397006175	membrane-bound complex binding site; other site
290397006176	hinge residues; other site
290397006177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
290397006178	dimer interface [polypeptide binding]; other site
290397006179	phosphorylation site [posttranslational modification]
290397006180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397006181	ATP binding site [chemical binding]; other site
290397006182	Mg2+ binding site [ion binding]; other site
290397006183	G-X-G motif; other site
290397006184	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290397006185	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
290397006186	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
290397006187	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
290397006188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397006189	S-adenosylmethionine binding site [chemical binding]; other site
290397006190	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
290397006191	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290397006192	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
290397006193	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
290397006194	hexamer interface [polypeptide binding]; other site
290397006195	ligand binding site [chemical binding]; other site
290397006196	putative active site [active]
290397006197	NAD(P) binding site [chemical binding]; other site
290397006198	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
290397006199	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
290397006200	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397006201	dimer interface [polypeptide binding]; other site
290397006202	active site
290397006203	glutathione binding site [chemical binding]; other site
290397006204	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
290397006205	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
290397006206	G1 box; other site
290397006207	putative GEF interaction site [polypeptide binding]; other site
290397006208	GTP/Mg2+ binding site [chemical binding]; other site
290397006209	Switch I region; other site
290397006210	G2 box; other site
290397006211	G3 box; other site
290397006212	Switch II region; other site
290397006213	G4 box; other site
290397006214	G5 box; other site
290397006215	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
290397006216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397006217	Coenzyme A binding pocket [chemical binding]; other site
290397006218	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290397006219	G1 box; other site
290397006220	GTP/Mg2+ binding site [chemical binding]; other site
290397006221	G2 box; other site
290397006222	Switch I region; other site
290397006223	G3 box; other site
290397006224	Switch II region; other site
290397006225	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
290397006226	G4 box; other site
290397006227	G5 box; other site
290397006228	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
290397006229	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397006230	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397006231	active site
290397006232	Putative exonuclease, RdgC; Region: RdgC; cl01122
290397006233	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
290397006234	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397006235	active site
290397006236	metal binding site [ion binding]; metal-binding site
290397006237	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290397006238	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397006239	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397006240	active site
290397006241	catalytic tetrad [active]
290397006242	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397006243	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
290397006244	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397006245	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397006246	active site
290397006247	ATP binding site [chemical binding]; other site
290397006248	substrate binding site [chemical binding]; other site
290397006249	activation loop (A-loop); other site
290397006250	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
290397006251	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
290397006252	Kelch motif; Region: Kelch_1; pfam01344
290397006253	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
290397006254	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290397006255	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
290397006256	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
290397006257	dimer interface [polypeptide binding]; other site
290397006258	TPP-binding site [chemical binding]; other site
290397006259	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
290397006260	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
290397006261	E3 interaction surface; other site
290397006262	lipoyl attachment site [posttranslational modification]; other site
290397006263	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
290397006264	E3 interaction surface; other site
290397006265	lipoyl attachment site [posttranslational modification]; other site
290397006266	e3 binding domain; Region: E3_binding; pfam02817
290397006267	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
290397006268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006269	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397006270	Walker A motif; other site
290397006271	ATP binding site [chemical binding]; other site
290397006272	Walker B motif; other site
290397006273	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397006274	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
290397006275	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
290397006276	Hemerythrin-like domain; Region: Hr-like; cd12108
290397006277	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
290397006278	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
290397006279	Walker A/P-loop; other site
290397006280	ATP binding site [chemical binding]; other site
290397006281	Q-loop/lid; other site
290397006282	ABC transporter signature motif; other site
290397006283	Walker B; other site
290397006284	D-loop; other site
290397006285	H-loop/switch region; other site
290397006286	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
290397006287	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
290397006288	Walker A/P-loop; other site
290397006289	ATP binding site [chemical binding]; other site
290397006290	Q-loop/lid; other site
290397006291	ABC transporter signature motif; other site
290397006292	Walker B; other site
290397006293	D-loop; other site
290397006294	H-loop/switch region; other site
290397006295	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
290397006296	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
290397006297	putative ligand binding site [chemical binding]; other site
290397006298	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
290397006299	TM-ABC transporter signature motif; other site
290397006300	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
290397006301	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
290397006302	TM-ABC transporter signature motif; other site
290397006303	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
290397006304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397006305	NAD(P) binding site [chemical binding]; other site
290397006306	active site
290397006307	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
290397006308	Asparaginase; Region: Asparaginase; pfam00710
290397006309	active site
290397006310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397006311	RNA polymerase sigma factor; Provisional; Region: PRK11924
290397006312	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290397006313	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
290397006314	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
290397006315	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397006316	catalytic residues [active]
290397006317	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
290397006318	putative deacylase active site [active]
290397006319	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290397006320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397006321	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
290397006322	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
290397006323	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290397006324	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397006325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397006326	ABC transporter; Region: ABC_tran_2; pfam12848
290397006327	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397006328	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
290397006329	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
290397006330	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
290397006331	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
290397006332	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
290397006333	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
290397006334	Transposase IS200 like; Region: Y1_Tnp; cl00848
290397006335	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
290397006336	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
290397006337	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
290397006338	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
290397006339	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
290397006340	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397006341	putative acyl-acceptor binding pocket; other site
290397006342	Hemerythrin-like domain; Region: Hr-like; cd12108
290397006343	Fe binding site [ion binding]; other site
290397006344	PAS domain S-box; Region: sensory_box; TIGR00229
290397006345	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397006346	putative active site [active]
290397006347	heme pocket [chemical binding]; other site
290397006348	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
290397006349	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
290397006350	[4Fe-4S] binding site [ion binding]; other site
290397006351	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006352	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006353	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006354	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
290397006355	molybdopterin cofactor binding site; other site
290397006356	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
290397006357	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
290397006358	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
290397006359	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
290397006360	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
290397006361	catalytic residue [active]
290397006362	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
290397006363	PilZ domain; Region: PilZ; pfam07238
290397006364	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
290397006365	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
290397006366	putative ligand binding site [chemical binding]; other site
290397006367	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
290397006368	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290397006369	TM-ABC transporter signature motif; other site
290397006370	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
290397006371	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
290397006372	TM-ABC transporter signature motif; other site
290397006373	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
290397006374	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
290397006375	Walker A/P-loop; other site
290397006376	ATP binding site [chemical binding]; other site
290397006377	Q-loop/lid; other site
290397006378	ABC transporter signature motif; other site
290397006379	Walker B; other site
290397006380	D-loop; other site
290397006381	H-loop/switch region; other site
290397006382	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
290397006383	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
290397006384	Walker A/P-loop; other site
290397006385	ATP binding site [chemical binding]; other site
290397006386	Q-loop/lid; other site
290397006387	ABC transporter signature motif; other site
290397006388	Walker B; other site
290397006389	D-loop; other site
290397006390	H-loop/switch region; other site
290397006391	hypothetical protein; Provisional; Region: PRK12378
290397006392	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
290397006393	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397006394	dimerization interface [polypeptide binding]; other site
290397006395	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397006396	dimer interface [polypeptide binding]; other site
290397006397	putative CheW interface [polypeptide binding]; other site
290397006398	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
290397006399	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
290397006400	active site 2 [active]
290397006401	active site 1 [active]
290397006402	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397006403	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397006404	DNA binding residues [nucleotide binding]
290397006405	dimerization interface [polypeptide binding]; other site
290397006406	SnoaL-like domain; Region: SnoaL_2; pfam12680
290397006407	Rubrerythrin [Energy production and conversion]; Region: COG1592
290397006408	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290397006409	binuclear metal center [ion binding]; other site
290397006410	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
290397006411	iron binding site [ion binding]; other site
290397006412	ResB-like family; Region: ResB; pfam05140
290397006413	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
290397006414	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
290397006415	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
290397006416	ATP binding site [chemical binding]; other site
290397006417	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397006418	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397006419	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
290397006420	putative dimerization interface [polypeptide binding]; other site
290397006421	FOG: CBS domain [General function prediction only]; Region: COG0517
290397006422	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
290397006423	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
290397006424	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397006425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397006426	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
290397006427	active site
290397006428	Cache domain; Region: Cache_1; pfam02743
290397006429	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397006430	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397006431	putative active site [active]
290397006432	heme pocket [chemical binding]; other site
290397006433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397006434	dimer interface [polypeptide binding]; other site
290397006435	phosphorylation site [posttranslational modification]
290397006436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397006437	ATP binding site [chemical binding]; other site
290397006438	Mg2+ binding site [ion binding]; other site
290397006439	G-X-G motif; other site
290397006440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006441	active site
290397006442	phosphorylation site [posttranslational modification]
290397006443	intermolecular recognition site; other site
290397006444	dimerization interface [polypeptide binding]; other site
290397006445	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397006446	catalytic residues [active]
290397006447	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
290397006448	dimerization interface [polypeptide binding]; other site
290397006449	putative effector binding pocket; other site
290397006450	EamA-like transporter family; Region: EamA; pfam00892
290397006451	Pirin-related protein [General function prediction only]; Region: COG1741
290397006452	Pirin; Region: Pirin; pfam02678
290397006453	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
290397006454	mercuric reductase; Validated; Region: PRK06370
290397006455	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397006456	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290397006457	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
290397006458	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290397006459	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290397006460	putative glycosyltransferase, TIGR04348 family; Region: TIGR04348
290397006461	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397006462	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
290397006463	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290397006464	membrane-bound complex binding site; other site
290397006465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397006466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397006467	dimer interface [polypeptide binding]; other site
290397006468	phosphorylation site [posttranslational modification]
290397006469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397006470	ATP binding site [chemical binding]; other site
290397006471	Mg2+ binding site [ion binding]; other site
290397006472	G-X-G motif; other site
290397006473	Response regulator receiver domain; Region: Response_reg; pfam00072
290397006474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006475	active site
290397006476	phosphorylation site [posttranslational modification]
290397006477	intermolecular recognition site; other site
290397006478	dimerization interface [polypeptide binding]; other site
290397006479	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
290397006480	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
290397006481	active site 1 [active]
290397006482	dimer interface [polypeptide binding]; other site
290397006483	hexamer interface [polypeptide binding]; other site
290397006484	active site 2 [active]
290397006485	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
290397006486	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397006487	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
290397006488	dimerization interface [polypeptide binding]; other site
290397006489	substrate binding pocket [chemical binding]; other site
290397006490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397006491	putative substrate translocation pore; other site
290397006492	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397006493	LysR family transcriptional regulator; Provisional; Region: PRK14997
290397006494	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397006495	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
290397006496	putative effector binding pocket; other site
290397006497	dimerization interface [polypeptide binding]; other site
290397006498	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
290397006499	putative FMN binding site [chemical binding]; other site
290397006500	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
290397006501	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397006502	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
290397006503	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290397006504	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
290397006505	5'-3' exonuclease; Region: 53EXOc; smart00475
290397006506	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
290397006507	active site
290397006508	metal binding site 1 [ion binding]; metal-binding site
290397006509	putative 5' ssDNA interaction site; other site
290397006510	metal binding site 3; metal-binding site
290397006511	metal binding site 2 [ion binding]; metal-binding site
290397006512	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
290397006513	putative DNA binding site [nucleotide binding]; other site
290397006514	putative metal binding site [ion binding]; other site
290397006515	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
290397006516	tetramer interface [polypeptide binding]; other site
290397006517	active site
290397006518	Mg2+/Mn2+ binding site [ion binding]; other site
290397006519	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
290397006520	Ubiquitin-like proteins; Region: UBQ; cl00155
290397006521	VPS10 domain; Region: VPS10; smart00602
290397006522	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
290397006523	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
290397006524	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
290397006525	malate dehydrogenase; Reviewed; Region: PRK06223
290397006526	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
290397006527	NAD(P) binding site [chemical binding]; other site
290397006528	dimer interface [polypeptide binding]; other site
290397006529	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290397006530	substrate binding site [chemical binding]; other site
290397006531	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
290397006532	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
290397006533	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
290397006534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397006535	S-adenosylmethionine binding site [chemical binding]; other site
290397006536	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
290397006537	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397006538	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
290397006539	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
290397006540	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397006541	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397006542	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397006543	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290397006544	Cupin domain; Region: Cupin_2; cl17218
290397006545	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
290397006546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
290397006547	DNA-binding site [nucleotide binding]; DNA binding site
290397006548	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397006549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397006550	homodimer interface [polypeptide binding]; other site
290397006551	catalytic residue [active]
290397006552	multidrug efflux protein; Reviewed; Region: PRK09579
290397006553	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397006554	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397006555	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
290397006556	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397006557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006558	active site
290397006559	phosphorylation site [posttranslational modification]
290397006560	intermolecular recognition site; other site
290397006561	dimerization interface [polypeptide binding]; other site
290397006562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006563	Walker A motif; other site
290397006564	ATP binding site [chemical binding]; other site
290397006565	Walker B motif; other site
290397006566	arginine finger; other site
290397006567	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397006568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397006569	dimer interface [polypeptide binding]; other site
290397006570	phosphorylation site [posttranslational modification]
290397006571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397006572	ATP binding site [chemical binding]; other site
290397006573	Mg2+ binding site [ion binding]; other site
290397006574	G-X-G motif; other site
290397006575	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397006576	dimerization interface [polypeptide binding]; other site
290397006577	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
290397006578	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
290397006579	Predicted membrane protein [Function unknown]; Region: COG2259
290397006580	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
290397006581	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
290397006582	tetrameric interface [polypeptide binding]; other site
290397006583	NAD binding site [chemical binding]; other site
290397006584	catalytic residues [active]
290397006585	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397006586	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
290397006587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
290397006588	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
290397006589	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397006590	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397006591	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397006592	DNA binding residues [nucleotide binding]
290397006593	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397006594	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397006595	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290397006596	TAP-like protein; Region: Abhydrolase_4; pfam08386
290397006597	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
290397006598	GAF domain; Region: GAF; pfam01590
290397006599	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290397006600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006601	Walker A motif; other site
290397006602	ATP binding site [chemical binding]; other site
290397006603	Walker B motif; other site
290397006604	arginine finger; other site
290397006605	OsmC-like protein; Region: OsmC; pfam02566
290397006606	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
290397006607	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397006608	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
290397006609	Predicted integral membrane protein [Function unknown]; Region: COG0392
290397006610	Uncharacterized conserved protein [Function unknown]; Region: COG2898
290397006611	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
290397006612	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
290397006613	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
290397006614	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
290397006615	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290397006616	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397006617	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290397006618	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290397006619	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290397006620	4Fe-4S binding domain; Region: Fer4; pfam00037
290397006621	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290397006622	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
290397006623	nucleotide binding site [chemical binding]; other site
290397006624	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290397006625	SBD interface [polypeptide binding]; other site
290397006626	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
290397006627	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
290397006628	tetramer interface [polypeptide binding]; other site
290397006629	active site
290397006630	Mg2+/Mn2+ binding site [ion binding]; other site
290397006631	OsmC-like protein; Region: OsmC; pfam02566
290397006632	Cupin; Region: Cupin_6; pfam12852
290397006633	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
290397006634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
290397006635	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397006636	S-adenosylmethionine binding site [chemical binding]; other site
290397006637	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
290397006638	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
290397006639	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
290397006640	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
290397006641	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
290397006642	Subunit I/III interface [polypeptide binding]; other site
290397006643	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
290397006644	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
290397006645	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
290397006646	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
290397006647	Cytochrome c; Region: Cytochrom_C; pfam00034
290397006648	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
290397006649	Cu(I) binding site [ion binding]; other site
290397006650	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
290397006651	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397006652	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
290397006653	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
290397006654	active site
290397006655	metal binding site [ion binding]; metal-binding site
290397006656	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
290397006657	DsrE/DsrF-like family; Region: DrsE; cl00672
290397006658	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
290397006659	Predicted secreted protein [Function unknown]; Region: COG5501
290397006660	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
290397006661	Cytochrome c; Region: Cytochrom_C; pfam00034
290397006662	Cytochrome c; Region: Cytochrom_C; cl11414
290397006663	bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113
290397006664	Moco binding site; other site
290397006665	metal coordination site [ion binding]; other site
290397006666	dimerization interface [polypeptide binding]; other site
290397006667	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
290397006668	SnoaL-like domain; Region: SnoaL_3; pfam13474
290397006669	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397006670	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290397006671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397006672	Q-loop/lid; other site
290397006673	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
290397006674	elongation factor G; Reviewed; Region: PRK12740
290397006675	G1 box; other site
290397006676	putative GEF interaction site [polypeptide binding]; other site
290397006677	GTP/Mg2+ binding site [chemical binding]; other site
290397006678	Switch I region; other site
290397006679	G2 box; other site
290397006680	G3 box; other site
290397006681	Switch II region; other site
290397006682	G4 box; other site
290397006683	G5 box; other site
290397006684	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
290397006685	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290397006686	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290397006687	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
290397006688	putative hydrophobic ligand binding site [chemical binding]; other site
290397006689	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
290397006690	Beta-lactamase; Region: Beta-lactamase; pfam00144
290397006691	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
290397006692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397006693	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
290397006694	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397006695	putative NAD(P) binding site [chemical binding]; other site
290397006696	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
290397006697	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
290397006698	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006699	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
290397006700	molybdopterin cofactor binding site; other site
290397006701	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397006702	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
290397006703	putative molybdopterin cofactor binding site; other site
290397006704	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
290397006705	NAD(P) binding pocket [chemical binding]; other site
290397006706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397006707	NAD(P) binding site [chemical binding]; other site
290397006708	active site
290397006709	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290397006710	lipoyl attachment site [posttranslational modification]; other site
290397006711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397006712	active site
290397006713	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
290397006714	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
290397006715	Moco binding site; other site
290397006716	metal coordination site [ion binding]; other site
290397006717	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
290397006718	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
290397006719	aspartate aminotransferase; Provisional; Region: PRK06836
290397006720	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397006721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397006722	homodimer interface [polypeptide binding]; other site
290397006723	catalytic residue [active]
290397006724	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
290397006725	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290397006726	dimer interface [polypeptide binding]; other site
290397006727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397006728	catalytic residue [active]
290397006729	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
290397006730	Predicted permease [General function prediction only]; Region: COG2985
290397006731	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
290397006732	TrkA-C domain; Region: TrkA_C; pfam02080
290397006733	TrkA-C domain; Region: TrkA_C; pfam02080
290397006734	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
290397006735	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
290397006736	Protein of unknown function (DUF554); Region: DUF554; pfam04474
290397006737	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
290397006738	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290397006739	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397006740	ATP binding site [chemical binding]; other site
290397006741	putative Mg++ binding site [ion binding]; other site
290397006742	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
290397006743	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290397006744	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290397006745	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290397006746	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
290397006747	HsdM N-terminal domain; Region: HsdM_N; pfam12161
290397006748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397006749	S-adenosylmethionine binding site [chemical binding]; other site
290397006750	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
290397006751	multiple promoter invertase; Provisional; Region: mpi; PRK13413
290397006752	catalytic residues [active]
290397006753	catalytic nucleophile [active]
290397006754	Presynaptic Site I dimer interface [polypeptide binding]; other site
290397006755	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
290397006756	Synaptic Flat tetramer interface [polypeptide binding]; other site
290397006757	Synaptic Site I dimer interface [polypeptide binding]; other site
290397006758	DNA binding site [nucleotide binding]
290397006759	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290397006760	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
290397006761	catalytic residues [active]
290397006762	catalytic nucleophile [active]
290397006763	Recombinase; Region: Recombinase; pfam07508
290397006764	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
290397006765	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
290397006766	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
290397006767	dimer interface [polypeptide binding]; other site
290397006768	ABC-ATPase subunit  interface; other site
290397006769	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
290397006770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397006771	Walker A/P-loop; other site
290397006772	ATP binding site [chemical binding]; other site
290397006773	Q-loop/lid; other site
290397006774	ABC transporter signature motif; other site
290397006775	Walker B; other site
290397006776	D-loop; other site
290397006777	H-loop/switch region; other site
290397006778	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
290397006779	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
290397006780	intersubunit interface [polypeptide binding]; other site
290397006781	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
290397006782	CoA-transferase family III; Region: CoA_transf_3; pfam02515
290397006783	SCP-2 sterol transfer family; Region: SCP2; pfam02036
290397006784	Response regulator receiver domain; Region: Response_reg; pfam00072
290397006785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006786	active site
290397006787	phosphorylation site [posttranslational modification]
290397006788	intermolecular recognition site; other site
290397006789	dimerization interface [polypeptide binding]; other site
290397006790	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290397006791	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290397006792	acyl-activating enzyme (AAE) consensus motif; other site
290397006793	putative AMP binding site [chemical binding]; other site
290397006794	putative active site [active]
290397006795	putative CoA binding site [chemical binding]; other site
290397006796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397006797	TPR motif; other site
290397006798	binding surface
290397006799	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
290397006800	GMP synthase; Reviewed; Region: guaA; PRK00074
290397006801	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
290397006802	AMP/PPi binding site [chemical binding]; other site
290397006803	candidate oxyanion hole; other site
290397006804	catalytic triad [active]
290397006805	potential glutamine specificity residues [chemical binding]; other site
290397006806	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
290397006807	ATP Binding subdomain [chemical binding]; other site
290397006808	Ligand Binding sites [chemical binding]; other site
290397006809	Dimerization subdomain; other site
290397006810	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
290397006811	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
290397006812	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
290397006813	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
290397006814	active site
290397006815	PilZ domain; Region: PilZ; cl01260
290397006816	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397006817	rod shape-determining protein MreB; Provisional; Region: PRK13930
290397006818	nucleotide binding site [chemical binding]; other site
290397006819	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290397006820	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290397006821	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
290397006822	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397006823	ligand binding site [chemical binding]; other site
290397006824	flexible hinge region; other site
290397006825	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
290397006826	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
290397006827	trimer interface [polypeptide binding]; other site
290397006828	putative metal binding site [ion binding]; other site
290397006829	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
290397006830	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290397006831	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397006832	FeS/SAM binding site; other site
290397006833	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
290397006834	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
290397006835	Peptidase family M48; Region: Peptidase_M48; pfam01435
290397006836	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290397006837	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397006838	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397006839	acyl-activating enzyme (AAE) consensus motif; other site
290397006840	acyl-activating enzyme (AAE) consensus motif; other site
290397006841	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397006842	AMP binding site [chemical binding]; other site
290397006843	active site
290397006844	CoA binding site [chemical binding]; other site
290397006845	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
290397006846	TRAM domain; Region: TRAM; cl01282
290397006847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397006848	PilZ domain; Region: PilZ; cl01260
290397006849	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
290397006850	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
290397006851	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
290397006852	putative acyltransferase; Provisional; Region: PRK05790
290397006853	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
290397006854	dimer interface [polypeptide binding]; other site
290397006855	active site
290397006856	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
290397006857	catalytic nucleophile [active]
290397006858	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
290397006859	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
290397006860	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
290397006861	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
290397006862	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
290397006863	active site residues [active]
290397006864	dimer interface [polypeptide binding]; other site
290397006865	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
290397006866	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
290397006867	Fe-S cluster binding site [ion binding]; other site
290397006868	active site
290397006869	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
290397006870	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
290397006871	Flavoprotein; Region: Flavoprotein; pfam02441
290397006872	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
290397006873	CAAX protease self-immunity; Region: Abi; pfam02517
290397006874	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
290397006875	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
290397006876	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
290397006877	putative RNA binding site [nucleotide binding]; other site
290397006878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397006879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397006880	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290397006881	FeS/SAM binding site; other site
290397006882	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290397006883	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397006884	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397006885	DNA binding residues [nucleotide binding]
290397006886	Putative zinc-finger; Region: zf-HC2; pfam13490
290397006887	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
290397006888	Response regulator receiver domain; Region: Response_reg; pfam00072
290397006889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006890	active site
290397006891	phosphorylation site [posttranslational modification]
290397006892	intermolecular recognition site; other site
290397006893	dimerization interface [polypeptide binding]; other site
290397006894	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
290397006895	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
290397006896	pantothenate kinase; Reviewed; Region: PRK13321
290397006897	Biotin operon repressor [Transcription]; Region: BirA; COG1654
290397006898	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
290397006899	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
290397006900	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
290397006901	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
290397006902	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
290397006903	dimerization interface [polypeptide binding]; other site
290397006904	active site
290397006905	valyl-tRNA synthetase; Provisional; Region: valS; PRK14900
290397006906	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
290397006907	HIGH motif; other site
290397006908	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290397006909	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
290397006910	active site
290397006911	KMSKS motif; other site
290397006912	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
290397006913	tRNA binding surface [nucleotide binding]; other site
290397006914	anticodon binding site; other site
290397006915	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
290397006916	Response regulator receiver domain; Region: Response_reg; pfam00072
290397006917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006918	active site
290397006919	phosphorylation site [posttranslational modification]
290397006920	intermolecular recognition site; other site
290397006921	dimerization interface [polypeptide binding]; other site
290397006922	CheW-like domain; Region: CheW; pfam01584
290397006923	Response regulator receiver domain; Region: Response_reg; pfam00072
290397006924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397006925	active site
290397006926	phosphorylation site [posttranslational modification]
290397006927	intermolecular recognition site; other site
290397006928	dimerization interface [polypeptide binding]; other site
290397006929	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397006930	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397006931	metal binding site [ion binding]; metal-binding site
290397006932	active site
290397006933	I-site; other site
290397006934	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
290397006935	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
290397006936	ring oligomerisation interface [polypeptide binding]; other site
290397006937	ATP/Mg binding site [chemical binding]; other site
290397006938	stacking interactions; other site
290397006939	hinge regions; other site
290397006940	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
290397006941	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290397006942	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
290397006943	active site
290397006944	nucleophile elbow; other site
290397006945	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290397006946	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397006947	Walker A/P-loop; other site
290397006948	ATP binding site [chemical binding]; other site
290397006949	Q-loop/lid; other site
290397006950	ABC transporter signature motif; other site
290397006951	Walker B; other site
290397006952	D-loop; other site
290397006953	H-loop/switch region; other site
290397006954	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
290397006955	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
290397006956	nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246
290397006957	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
290397006958	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
290397006959	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290397006960	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
290397006961	interchain domain interface [polypeptide binding]; other site
290397006962	intrachain domain interface; other site
290397006963	heme bL binding site [chemical binding]; other site
290397006964	heme bH binding site [chemical binding]; other site
290397006965	Qo binding site; other site
290397006966	intrachain domain interface; other site
290397006967	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
290397006968	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
290397006969	Qo binding site; other site
290397006970	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
290397006971	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
290397006972	iron-sulfur cluster [ion binding]; other site
290397006973	[2Fe-2S] cluster binding site [ion binding]; other site
290397006974	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
290397006975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397006976	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
290397006977	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290397006978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006979	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397006980	Walker A motif; other site
290397006981	ATP binding site [chemical binding]; other site
290397006982	Walker B motif; other site
290397006983	arginine finger; other site
290397006984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397006985	Walker A motif; other site
290397006986	ATP binding site [chemical binding]; other site
290397006987	Walker B motif; other site
290397006988	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290397006989	Rossmann-like domain; Region: Rossmann-like; pfam10727
290397006990	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
290397006991	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
290397006992	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
290397006993	active site
290397006994	(T/H)XGH motif; other site
290397006995	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
290397006996	Caspase domain; Region: Peptidase_C14; pfam00656
290397006997	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290397006998	DNA binding residues [nucleotide binding]
290397006999	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290397007000	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
290397007001	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
290397007002	NodB motif; other site
290397007003	active site
290397007004	catalytic site [active]
290397007005	metal binding site [ion binding]; metal-binding site
290397007006	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397007007	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397007008	MutS domain III; Region: MutS_III; pfam05192
290397007009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397007010	Walker A/P-loop; other site
290397007011	ATP binding site [chemical binding]; other site
290397007012	Q-loop/lid; other site
290397007013	ABC transporter signature motif; other site
290397007014	Walker B; other site
290397007015	D-loop; other site
290397007016	H-loop/switch region; other site
290397007017	Smr domain; Region: Smr; pfam01713
290397007018	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
290397007019	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
290397007020	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
290397007021	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290397007022	TM-ABC transporter signature motif; other site
290397007023	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
290397007024	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
290397007025	TM-ABC transporter signature motif; other site
290397007026	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
290397007027	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
290397007028	Walker A/P-loop; other site
290397007029	ATP binding site [chemical binding]; other site
290397007030	Q-loop/lid; other site
290397007031	ABC transporter signature motif; other site
290397007032	Walker B; other site
290397007033	D-loop; other site
290397007034	H-loop/switch region; other site
290397007035	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
290397007036	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
290397007037	Walker A/P-loop; other site
290397007038	ATP binding site [chemical binding]; other site
290397007039	Q-loop/lid; other site
290397007040	ABC transporter signature motif; other site
290397007041	Walker B; other site
290397007042	D-loop; other site
290397007043	H-loop/switch region; other site
290397007044	FOG: CBS domain [General function prediction only]; Region: COG0517
290397007045	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
290397007046	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290397007047	ribonuclease R; Region: RNase_R; TIGR02063
290397007048	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
290397007049	RNB domain; Region: RNB; pfam00773
290397007050	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
290397007051	RNA binding site [nucleotide binding]; other site
290397007052	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
290397007053	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
290397007054	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
290397007055	dimer interface [polypeptide binding]; other site
290397007056	putative functional site; other site
290397007057	putative MPT binding site; other site
290397007058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
290397007059	phosphorylation site [posttranslational modification]
290397007060	intermolecular recognition site; other site
290397007061	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397007062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397007063	non-specific DNA binding site [nucleotide binding]; other site
290397007064	salt bridge; other site
290397007065	sequence-specific DNA binding site [nucleotide binding]; other site
290397007066	oxidative damage protection protein; Provisional; Region: PRK05408
290397007067	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290397007068	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290397007069	Methyltransferase domain; Region: Methyltransf_11; pfam08241
290397007070	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
290397007071	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
290397007072	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
290397007073	TPP-binding site [chemical binding]; other site
290397007074	tetramer interface [polypeptide binding]; other site
290397007075	heterodimer interface [polypeptide binding]; other site
290397007076	phosphorylation loop region [posttranslational modification]
290397007077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397007078	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
290397007079	dimerization interface [polypeptide binding]; other site
290397007080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007081	Response regulator receiver domain; Region: Response_reg; pfam00072
290397007082	active site
290397007083	phosphorylation site [posttranslational modification]
290397007084	intermolecular recognition site; other site
290397007085	dimerization interface [polypeptide binding]; other site
290397007086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397007087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397007088	ATP binding site [chemical binding]; other site
290397007089	Mg2+ binding site [ion binding]; other site
290397007090	G-X-G motif; other site
290397007091	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
290397007092	homodimer interface [polypeptide binding]; other site
290397007093	homotetramer interface [polypeptide binding]; other site
290397007094	active site pocket [active]
290397007095	cleavage site
290397007096	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
290397007097	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397007098	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
290397007099	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
290397007100	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397007101	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
290397007102	dimer interface [polypeptide binding]; other site
290397007103	active site
290397007104	Schiff base residues; other site
290397007105	Uncharacterized conserved protein [Function unknown]; Region: COG4198
290397007106	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
290397007107	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
290397007108	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
290397007109	Bacterial sugar transferase; Region: Bac_transf; pfam02397
290397007110	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
290397007111	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
290397007112	DXD motif; other site
290397007113	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290397007114	active site
290397007115	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397007116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397007117	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
290397007118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397007119	putative homodimer interface [polypeptide binding]; other site
290397007120	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
290397007121	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
290397007122	Walker A/P-loop; other site
290397007123	ATP binding site [chemical binding]; other site
290397007124	Q-loop/lid; other site
290397007125	ABC transporter signature motif; other site
290397007126	Walker B; other site
290397007127	D-loop; other site
290397007128	H-loop/switch region; other site
290397007129	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
290397007130	Predicted permeases [General function prediction only]; Region: COG0795
290397007131	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290397007132	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
290397007133	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290397007134	AIR carboxylase; Region: AIRC; pfam00731
290397007135	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
290397007136	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
290397007137	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
290397007138	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
290397007139	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
290397007140	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
290397007141	purine monophosphate binding site [chemical binding]; other site
290397007142	dimer interface [polypeptide binding]; other site
290397007143	putative catalytic residues [active]
290397007144	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
290397007145	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
290397007146	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397007147	DNA binding residues [nucleotide binding]
290397007148	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
290397007149	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397007150	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397007151	active site
290397007152	ATP binding site [chemical binding]; other site
290397007153	substrate binding site [chemical binding]; other site
290397007154	activation loop (A-loop); other site
290397007155	PEGA domain; Region: PEGA; pfam08308
290397007156	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
290397007157	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
290397007158	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
290397007159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007160	NAD(P) binding site [chemical binding]; other site
290397007161	active site
290397007162	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290397007163	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
290397007164	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
290397007165	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
290397007166	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
290397007167	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
290397007168	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
290397007169	hydroxyglutarate oxidase; Provisional; Region: PRK11728
290397007170	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
290397007171	pyrroline-5-carboxylate reductase; Region: PLN02688
290397007172	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
290397007173	putative dimer interface [polypeptide binding]; other site
290397007174	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
290397007175	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
290397007176	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
290397007177	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
290397007178	active site
290397007179	effector binding site; other site
290397007180	dimer interface [polypeptide binding]; other site
290397007181	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
290397007182	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
290397007183	active site
290397007184	PHP-associated; Region: PHP_C; pfam13263
290397007185	Uncharacterized conserved protein [Function unknown]; Region: COG0585
290397007186	Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577
290397007187	active site
290397007188	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
290397007189	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
290397007190	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
290397007191	active site
290397007192	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
290397007193	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
290397007194	domain interfaces; other site
290397007195	active site
290397007196	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
290397007197	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
290397007198	tRNA; other site
290397007199	putative tRNA binding site [nucleotide binding]; other site
290397007200	putative NADP binding site [chemical binding]; other site
290397007201	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
290397007202	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290397007203	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397007204	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397007205	catalytic residues [active]
290397007206	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
290397007207	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
290397007208	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290397007209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290397007210	rod shape-determining protein MreC; Provisional; Region: PRK13922
290397007211	rod shape-determining protein MreC; Region: MreC; pfam04085
290397007212	SurA N-terminal domain; Region: SurA_N_3; cl07813
290397007213	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290397007214	Maf-like protein; Region: Maf; pfam02545
290397007215	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
290397007216	active site
290397007217	dimer interface [polypeptide binding]; other site
290397007218	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
290397007219	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290397007220	catalytic residue [active]
290397007221	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
290397007222	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
290397007223	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
290397007224	Protein of unknown function (DUF507); Region: DUF507; pfam04368
290397007225	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
290397007226	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
290397007227	putative active site; other site
290397007228	catalytic residue [active]
290397007229	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
290397007230	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290397007231	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290397007232	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
290397007233	active site
290397007234	FtsJ-like methyltransferase; Region: FtsJ; cl17430
290397007235	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397007236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397007237	S-adenosylmethionine binding site [chemical binding]; other site
290397007238	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290397007239	active site
290397007240	thiamine phosphate binding site [chemical binding]; other site
290397007241	pyrophosphate binding site [ion binding]; other site
290397007242	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
290397007243	ThiS interaction site; other site
290397007244	putative active site [active]
290397007245	tetramer interface [polypeptide binding]; other site
290397007246	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
290397007247	thiS-thiF/thiG interaction site; other site
290397007248	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
290397007249	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
290397007250	dimerization interface [polypeptide binding]; other site
290397007251	DPS ferroxidase diiron center [ion binding]; other site
290397007252	ion pore; other site
290397007253	Uncharacterized conserved protein [Function unknown]; Region: COG0398
290397007254	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
290397007255	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397007256	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397007257	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397007258	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397007259	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397007260	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
290397007261	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397007262	ATP binding site [chemical binding]; other site
290397007263	putative Mg++ binding site [ion binding]; other site
290397007264	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397007265	nucleotide binding region [chemical binding]; other site
290397007266	ATP-binding site [chemical binding]; other site
290397007267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397007268	non-specific DNA binding site [nucleotide binding]; other site
290397007269	salt bridge; other site
290397007270	sequence-specific DNA binding site [nucleotide binding]; other site
290397007271	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
290397007272	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
290397007273	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397007274	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
290397007275	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290397007276	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
290397007277	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
290397007278	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
290397007279	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
290397007280	hydroxyglutarate oxidase; Provisional; Region: PRK11728
290397007281	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
290397007282	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
290397007283	dimer interface [polypeptide binding]; other site
290397007284	anticodon binding site; other site
290397007285	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
290397007286	homodimer interface [polypeptide binding]; other site
290397007287	motif 1; other site
290397007288	active site
290397007289	motif 2; other site
290397007290	GAD domain; Region: GAD; pfam02938
290397007291	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290397007292	active site
290397007293	motif 3; other site
290397007294	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
290397007295	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
290397007296	NADP binding site [chemical binding]; other site
290397007297	dimer interface [polypeptide binding]; other site
290397007298	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
290397007299	DHH family; Region: DHH; pfam01368
290397007300	DHHA1 domain; Region: DHHA1; pfam02272
290397007301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
290397007302	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397007303	active site
290397007304	phosphorylation site [posttranslational modification]
290397007305	intermolecular recognition site; other site
290397007306	dimerization interface [polypeptide binding]; other site
290397007307	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
290397007308	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
290397007309	Protein export membrane protein; Region: SecD_SecF; pfam02355
290397007310	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
290397007311	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
290397007312	Preprotein translocase subunit; Region: YajC; pfam02699
290397007313	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
290397007314	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
290397007315	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
290397007316	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
290397007317	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
290397007318	Stage II sporulation protein; Region: SpoIID; pfam08486
290397007319	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290397007320	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
290397007321	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
290397007322	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
290397007323	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
290397007324	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
290397007325	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397007326	FeS/SAM binding site; other site
290397007327	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
290397007328	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
290397007329	homotrimer interaction site [polypeptide binding]; other site
290397007330	putative active site [active]
290397007331	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
290397007332	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397007333	Zn2+ binding site [ion binding]; other site
290397007334	Mg2+ binding site [ion binding]; other site
290397007335	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
290397007336	synthetase active site [active]
290397007337	NTP binding site [chemical binding]; other site
290397007338	metal binding site [ion binding]; metal-binding site
290397007339	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
290397007340	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
290397007341	Double zinc ribbon; Region: DZR; pfam12773
290397007342	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
290397007343	Zn binding site [ion binding]; other site
290397007344	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
290397007345	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397007346	phosphopeptide binding site; other site
290397007347	Domain of unknown function DUF77; Region: DUF77; pfam01910
290397007348	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397007349	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397007350	phosphopeptide binding site; other site
290397007351	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397007352	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397007353	phosphopeptide binding site; other site
290397007354	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
290397007355	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
290397007356	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
290397007357	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
290397007358	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
290397007359	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
290397007360	MPT binding site; other site
290397007361	trimer interface [polypeptide binding]; other site
290397007362	hypothetical protein; Provisional; Region: PRK08609
290397007363	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
290397007364	active site
290397007365	primer binding site [nucleotide binding]; other site
290397007366	NTP  binding site [chemical binding]; other site
290397007367	metal binding triad [ion binding]; metal-binding site
290397007368	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
290397007369	active site
290397007370	muropeptide transporter; Reviewed; Region: ampG; PRK11902
290397007371	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
290397007372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397007373	putative substrate translocation pore; other site
290397007374	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
290397007375	4Fe-4S binding domain; Region: Fer4; pfam00037
290397007376	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
290397007377	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290397007378	catalytic loop [active]
290397007379	iron binding site [ion binding]; other site
290397007380	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
290397007381	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397007382	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397007383	NADH dehydrogenase subunit D; Validated; Region: PRK06075
290397007384	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
290397007385	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
290397007386	NADH dehydrogenase subunit B; Provisional; Region: PRK14817
290397007387	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
290397007388	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
290397007389	NADH dehydrogenase subunit B; Provisional; Region: PRK14818
290397007390	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
290397007391	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
290397007392	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
290397007393	NADH dehydrogenase subunit D; Validated; Region: PRK06075
290397007394	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
290397007395	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
290397007396	4Fe-4S binding domain; Region: Fer4; pfam00037
290397007397	4Fe-4S binding domain; Region: Fer4; pfam00037
290397007398	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
290397007399	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
290397007400	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
290397007401	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397007402	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397007403	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
290397007404	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
290397007405	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397007406	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
290397007407	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397007408	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
290397007409	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290397007410	active site
290397007411	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290397007412	Predicted transcriptional regulator [Transcription]; Region: COG1959
290397007413	Transcriptional regulator; Region: Rrf2; pfam02082
290397007414	agmatinase; Region: agmatinase; TIGR01230
290397007415	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
290397007416	putative active site [active]
290397007417	Mn binding site [ion binding]; other site
290397007418	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
290397007419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397007420	Walker A motif; other site
290397007421	ATP binding site [chemical binding]; other site
290397007422	Walker B motif; other site
290397007423	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
290397007424	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397007425	HSP70 interaction site [polypeptide binding]; other site
290397007426	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397007427	nucleotide binding site [chemical binding]; other site
290397007428	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
290397007429	putative dimer interface [polypeptide binding]; other site
290397007430	putative active site [active]
290397007431	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
290397007432	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397007433	Zn2+ binding site [ion binding]; other site
290397007434	Mg2+ binding site [ion binding]; other site
290397007435	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
290397007436	CAAX protease self-immunity; Region: Abi; pfam02517
290397007437	Protein metal binding site; Region: Cu-binding_MopE; pfam11617
290397007438	Response regulator receiver domain; Region: Response_reg; pfam00072
290397007439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007440	active site
290397007441	phosphorylation site [posttranslational modification]
290397007442	intermolecular recognition site; other site
290397007443	dimerization interface [polypeptide binding]; other site
290397007444	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
290397007445	putative ligand binding pocket/active site [active]
290397007446	putative metal binding site [ion binding]; other site
290397007447	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
290397007448	active site
290397007449	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
290397007450	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290397007451	active site
290397007452	HIGH motif; other site
290397007453	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290397007454	active site
290397007455	KMSKS motif; other site
290397007456	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
290397007457	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397007458	active site
290397007459	HIGH motif; other site
290397007460	nucleotide binding site [chemical binding]; other site
290397007461	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
290397007462	KMSKS motif; other site
290397007463	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
290397007464	Aspartase; Region: Aspartase; cd01357
290397007465	aspartate ammonia-lyase; Provisional; Region: PRK13353
290397007466	active sites [active]
290397007467	tetramer interface [polypeptide binding]; other site
290397007468	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397007469	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
290397007470	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
290397007471	catalytic site [active]
290397007472	G-X2-G-X-G-K; other site
290397007473	hypothetical protein; Provisional; Region: PRK11820
290397007474	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
290397007475	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
290397007476	Trm112p-like protein; Region: Trm112p; cl01066
290397007477	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397007478	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397007479	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
290397007480	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397007481	active site
290397007482	nucleotide binding site [chemical binding]; other site
290397007483	HIGH motif; other site
290397007484	KMSKS motif; other site
290397007485	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
290397007486	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
290397007487	putative ribose interaction site [chemical binding]; other site
290397007488	putative ADP binding site [chemical binding]; other site
290397007489	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
290397007490	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
290397007491	putative acyl-acceptor binding pocket; other site
290397007492	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
290397007493	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290397007494	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
290397007495	putative active site [active]
290397007496	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
290397007497	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
290397007498	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397007499	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
290397007500	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
290397007501	active site
290397007502	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
290397007503	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290397007504	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
290397007505	Walker A/P-loop; other site
290397007506	ATP binding site [chemical binding]; other site
290397007507	Q-loop/lid; other site
290397007508	ABC transporter signature motif; other site
290397007509	Walker B; other site
290397007510	D-loop; other site
290397007511	H-loop/switch region; other site
290397007512	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290397007513	elongation factor G; Reviewed; Region: PRK12740
290397007514	G1 box; other site
290397007515	GTP/Mg2+ binding site [chemical binding]; other site
290397007516	G2 box; other site
290397007517	Switch I region; other site
290397007518	G3 box; other site
290397007519	Switch II region; other site
290397007520	G4 box; other site
290397007521	G5 box; other site
290397007522	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290397007523	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290397007524	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290397007525	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
290397007526	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
290397007527	active site
290397007528	acyl-activating enzyme (AAE) consensus motif; other site
290397007529	putative CoA binding site [chemical binding]; other site
290397007530	AMP binding site [chemical binding]; other site
290397007531	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
290397007532	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
290397007533	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
290397007534	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
290397007535	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
290397007536	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397007537	catalytic residue [active]
290397007538	MarC family integral membrane protein; Region: MarC; pfam01914
290397007539	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
290397007540	Ligand binding site; other site
290397007541	Putative Catalytic site; other site
290397007542	DXD motif; other site
290397007543	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
290397007544	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
290397007545	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397007546	dimerization interface [polypeptide binding]; other site
290397007547	putative DNA binding site [nucleotide binding]; other site
290397007548	putative Zn2+ binding site [ion binding]; other site
290397007549	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290397007550	active site residue [active]
290397007551	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
290397007552	4Fe-4S binding domain; Region: Fer4; pfam00037
290397007553	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290397007554	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290397007555	thiosulfate reductase PhsA; Provisional; Region: PRK15488
290397007556	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
290397007557	putative [Fe4-S4] binding site [ion binding]; other site
290397007558	putative molybdopterin cofactor binding site [chemical binding]; other site
290397007559	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
290397007560	putative molybdopterin cofactor binding site; other site
290397007561	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
290397007562	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397007563	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397007564	putative active site [active]
290397007565	heme pocket [chemical binding]; other site
290397007566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397007567	dimer interface [polypeptide binding]; other site
290397007568	phosphorylation site [posttranslational modification]
290397007569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397007570	ATP binding site [chemical binding]; other site
290397007571	Mg2+ binding site [ion binding]; other site
290397007572	G-X-G motif; other site
290397007573	Response regulator receiver domain; Region: Response_reg; pfam00072
290397007574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007575	active site
290397007576	phosphorylation site [posttranslational modification]
290397007577	intermolecular recognition site; other site
290397007578	dimerization interface [polypeptide binding]; other site
290397007579	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
290397007580	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
290397007581	putative Iron-sulfur protein interface [polypeptide binding]; other site
290397007582	proximal heme binding site [chemical binding]; other site
290397007583	distal heme binding site [chemical binding]; other site
290397007584	putative dimer interface [polypeptide binding]; other site
290397007585	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
290397007586	L-aspartate oxidase; Provisional; Region: PRK06175
290397007587	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290397007588	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
290397007589	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
290397007590	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290397007591	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
290397007592	putative ADP-binding pocket [chemical binding]; other site
290397007593	O-Antigen ligase; Region: Wzy_C; cl04850
290397007594	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
290397007595	putative homodimer interface [polypeptide binding]; other site
290397007596	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
290397007597	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
290397007598	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
290397007599	putative active site [active]
290397007600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
290397007601	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397007602	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
290397007603	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397007604	catalytic residue [active]
290397007605	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397007606	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
290397007607	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
290397007608	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
290397007609	phosphate binding site [ion binding]; other site
290397007610	putative substrate binding pocket [chemical binding]; other site
290397007611	dimer interface [polypeptide binding]; other site
290397007612	Bacterial sugar transferase; Region: Bac_transf; pfam02397
290397007613	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
290397007614	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
290397007615	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
290397007616	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
290397007617	SLBB domain; Region: SLBB; pfam10531
290397007618	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397007619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007620	active site
290397007621	phosphorylation site [posttranslational modification]
290397007622	intermolecular recognition site; other site
290397007623	dimerization interface [polypeptide binding]; other site
290397007624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397007625	Walker A motif; other site
290397007626	ATP binding site [chemical binding]; other site
290397007627	Walker B motif; other site
290397007628	arginine finger; other site
290397007629	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290397007630	active site residue [active]
290397007631	Stage II sporulation protein; Region: SpoIID; pfam08486
290397007632	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
290397007633	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290397007634	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
290397007635	homodimer interface [polypeptide binding]; other site
290397007636	substrate-cofactor binding pocket; other site
290397007637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397007638	catalytic residue [active]
290397007639	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397007640	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397007641	Walker A/P-loop; other site
290397007642	ATP binding site [chemical binding]; other site
290397007643	Q-loop/lid; other site
290397007644	ABC transporter signature motif; other site
290397007645	Walker B; other site
290397007646	D-loop; other site
290397007647	H-loop/switch region; other site
290397007648	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397007649	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397007650	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397007651	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397007652	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
290397007653	short chain dehydrogenase; Provisional; Region: PRK07109
290397007654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007655	NAD(P) binding site [chemical binding]; other site
290397007656	active site
290397007657	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290397007658	putative phosphate binding site [ion binding]; other site
290397007659	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
290397007660	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
290397007661	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
290397007662	4Fe-4S binding domain; Region: Fer4; pfam00037
290397007663	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
290397007664	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397007665	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
290397007666	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290397007667	dimer interface [polypeptide binding]; other site
290397007668	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397007669	catalytic residue [active]
290397007670	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
290397007671	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
290397007672	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
290397007673	Low affinity iron permease; Region: Iron_permease; cl12096
290397007674	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
290397007675	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
290397007676	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397007677	Ligand Binding Site [chemical binding]; other site
290397007678	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
290397007679	FAD binding site [chemical binding]; other site
290397007680	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
290397007681	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
290397007682	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290397007683	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290397007684	putative catalytic site [active]
290397007685	putative metal binding site [ion binding]; other site
290397007686	putative phosphate binding site [ion binding]; other site
290397007687	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
290397007688	G1 box; other site
290397007689	GTP/Mg2+ binding site [chemical binding]; other site
290397007690	Switch I region; other site
290397007691	G2 box; other site
290397007692	G3 box; other site
290397007693	Switch II region; other site
290397007694	G4 box; other site
290397007695	G5 box; other site
290397007696	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
290397007697	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
290397007698	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
290397007699	CoA-binding site [chemical binding]; other site
290397007700	ATP-binding [chemical binding]; other site
290397007701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007702	NAD(P) binding site [chemical binding]; other site
290397007703	active site
290397007704	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
290397007705	active site 2 [active]
290397007706	active site 1 [active]
290397007707	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
290397007708	active site
290397007709	catalytic site [active]
290397007710	TPR repeat; Region: TPR_11; pfam13414
290397007711	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
290397007712	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
290397007713	nucleotide binding site [chemical binding]; other site
290397007714	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
290397007715	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397007716	HSP70 interaction site [polypeptide binding]; other site
290397007717	ornithine carbamoyltransferase; Provisional; Region: PRK00779
290397007718	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290397007719	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290397007720	acetylornithine aminotransferase; Provisional; Region: PRK02627
290397007721	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290397007722	inhibitor-cofactor binding pocket; inhibition site
290397007723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397007724	catalytic residue [active]
290397007725	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
290397007726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397007727	Walker A motif; other site
290397007728	ATP binding site [chemical binding]; other site
290397007729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290397007730	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290397007731	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
290397007732	active site
290397007733	HslU subunit interaction site [polypeptide binding]; other site
290397007734	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
290397007735	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
290397007736	active site
290397007737	DNA binding site [nucleotide binding]
290397007738	Int/Topo IB signature motif; other site
290397007739	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
290397007740	Glucose inhibited division protein A; Region: GIDA; pfam01134
290397007741	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
290397007742	DNA topoisomerase I; Validated; Region: PRK06599
290397007743	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
290397007744	active site
290397007745	interdomain interaction site; other site
290397007746	putative metal-binding site [ion binding]; other site
290397007747	nucleotide binding site [chemical binding]; other site
290397007748	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
290397007749	domain I; other site
290397007750	DNA binding groove [nucleotide binding]
290397007751	phosphate binding site [ion binding]; other site
290397007752	domain II; other site
290397007753	domain III; other site
290397007754	nucleotide binding site [chemical binding]; other site
290397007755	catalytic site [active]
290397007756	domain IV; other site
290397007757	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290397007758	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
290397007759	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290397007760	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290397007761	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
290397007762	DNA protecting protein DprA; Region: dprA; TIGR00732
290397007763	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397007764	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
290397007765	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
290397007766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397007767	dimerization interface [polypeptide binding]; other site
290397007768	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397007769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397007770	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397007771	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397007772	metal binding site [ion binding]; metal-binding site
290397007773	active site
290397007774	I-site; other site
290397007775	Response regulator receiver domain; Region: Response_reg; pfam00072
290397007776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007777	active site
290397007778	phosphorylation site [posttranslational modification]
290397007779	intermolecular recognition site; other site
290397007780	dimerization interface [polypeptide binding]; other site
290397007781	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
290397007782	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
290397007783	active site
290397007784	metal binding site [ion binding]; metal-binding site
290397007785	MoxR-like ATPases [General function prediction only]; Region: COG0714
290397007786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397007787	Walker A motif; other site
290397007788	ATP binding site [chemical binding]; other site
290397007789	Walker B motif; other site
290397007790	arginine finger; other site
290397007791	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
290397007792	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
290397007793	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
290397007794	putative ADP-binding pocket [chemical binding]; other site
290397007795	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397007796	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397007797	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
290397007798	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
290397007799	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397007800	Walker A motif; other site
290397007801	ATP binding site [chemical binding]; other site
290397007802	Walker B motif; other site
290397007803	PilZ domain; Region: PilZ; cl01260
290397007804	This domain is found in peptide chain release factors; Region: PCRF; smart00937
290397007805	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
290397007806	RF-1 domain; Region: RF-1; pfam00472
290397007807	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
290397007808	putative active site [active]
290397007809	catalytic triad [active]
290397007810	putative dimer interface [polypeptide binding]; other site
290397007811	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
290397007812	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397007813	Zn2+ binding site [ion binding]; other site
290397007814	Mg2+ binding site [ion binding]; other site
290397007815	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
290397007816	PhoH-like protein; Region: PhoH; pfam02562
290397007817	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397007818	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397007819	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
290397007820	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
290397007821	homodimer interface [polypeptide binding]; other site
290397007822	metal binding site [ion binding]; metal-binding site
290397007823	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
290397007824	homodimer interface [polypeptide binding]; other site
290397007825	active site
290397007826	putative chemical substrate binding site [chemical binding]; other site
290397007827	metal binding site [ion binding]; metal-binding site
290397007828	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
290397007829	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
290397007830	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
290397007831	HIGH motif; other site
290397007832	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290397007833	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290397007834	active site
290397007835	KMSKS motif; other site
290397007836	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
290397007837	tRNA binding surface [nucleotide binding]; other site
290397007838	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
290397007839	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
290397007840	putative dimer interface [polypeptide binding]; other site
290397007841	putative anticodon binding site; other site
290397007842	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
290397007843	homodimer interface [polypeptide binding]; other site
290397007844	motif 1; other site
290397007845	motif 2; other site
290397007846	active site
290397007847	motif 3; other site
290397007848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007849	Response regulator receiver domain; Region: Response_reg; pfam00072
290397007850	active site
290397007851	phosphorylation site [posttranslational modification]
290397007852	intermolecular recognition site; other site
290397007853	dimerization interface [polypeptide binding]; other site
290397007854	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
290397007855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007856	active site
290397007857	phosphorylation site [posttranslational modification]
290397007858	intermolecular recognition site; other site
290397007859	dimerization interface [polypeptide binding]; other site
290397007860	CheB methylesterase; Region: CheB_methylest; pfam01339
290397007861	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290397007862	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397007863	HEAT repeats; Region: HEAT_2; pfam13646
290397007864	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
290397007865	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
290397007866	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
290397007867	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
290397007868	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397007869	putative binding surface; other site
290397007870	active site
290397007871	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
290397007872	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
290397007873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397007874	ATP binding site [chemical binding]; other site
290397007875	Mg2+ binding site [ion binding]; other site
290397007876	G-X-G motif; other site
290397007877	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
290397007878	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
290397007879	putative RNA binding site [nucleotide binding]; other site
290397007880	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
290397007881	homopentamer interface [polypeptide binding]; other site
290397007882	active site
290397007883	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
290397007884	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
290397007885	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
290397007886	dimerization interface [polypeptide binding]; other site
290397007887	active site
290397007888	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
290397007889	Lumazine binding domain; Region: Lum_binding; pfam00677
290397007890	Lumazine binding domain; Region: Lum_binding; pfam00677
290397007891	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
290397007892	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
290397007893	catalytic motif [active]
290397007894	Zn binding site [ion binding]; other site
290397007895	RibD C-terminal domain; Region: RibD_C; cl17279
290397007896	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
290397007897	ATP cone domain; Region: ATP-cone; pfam03477
290397007898	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
290397007899	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
290397007900	dimer interface [polypeptide binding]; other site
290397007901	active site
290397007902	glycine-pyridoxal phosphate binding site [chemical binding]; other site
290397007903	folate binding site [chemical binding]; other site
290397007904	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
290397007905	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
290397007906	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
290397007907	dimer interface [polypeptide binding]; other site
290397007908	active site
290397007909	acyl carrier protein; Provisional; Region: acpP; PRK00982
290397007910	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
290397007911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007912	NAD(P) binding site [chemical binding]; other site
290397007913	active site
290397007914	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
290397007915	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
290397007916	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
290397007917	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
290397007918	dimer interface [polypeptide binding]; other site
290397007919	active site
290397007920	CoA binding pocket [chemical binding]; other site
290397007921	putative phosphate acyltransferase; Provisional; Region: PRK05331
290397007922	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
290397007923	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
290397007924	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397007925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397007926	active site
290397007927	phosphorylation site [posttranslational modification]
290397007928	intermolecular recognition site; other site
290397007929	dimerization interface [polypeptide binding]; other site
290397007930	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397007931	DNA binding residues [nucleotide binding]
290397007932	dimerization interface [polypeptide binding]; other site
290397007933	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
290397007934	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
290397007935	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
290397007936	GIY-YIG motif/motif A; other site
290397007937	active site
290397007938	catalytic site [active]
290397007939	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
290397007940	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007941	NAD(P) binding site [chemical binding]; other site
290397007942	active site
290397007943	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
290397007944	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
290397007945	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
290397007946	putative active site [active]
290397007947	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397007948	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
290397007949	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
290397007950	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397007951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397007952	NAD(P) binding site [chemical binding]; other site
290397007953	active site
290397007954	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290397007955	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
290397007956	putative ADP-binding pocket [chemical binding]; other site
290397007957	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
290397007958	Bacterial sugar transferase; Region: Bac_transf; pfam02397
290397007959	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
290397007960	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
290397007961	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
290397007962	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
290397007963	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290397007964	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290397007965	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
290397007966	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290397007967	active site
290397007968	homodimer interface [polypeptide binding]; other site
290397007969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397007970	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290397007971	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
290397007972	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
290397007973	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290397007974	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290397007975	active site
290397007976	O-Antigen ligase; Region: Wzy_C; pfam04932
290397007977	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
290397007978	Right handed beta helix region; Region: Beta_helix; pfam13229
290397007979	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
290397007980	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
290397007981	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
290397007982	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
290397007983	active site
290397007984	dimer interface [polypeptide binding]; other site
290397007985	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
290397007986	Ligand Binding Site [chemical binding]; other site
290397007987	Molecular Tunnel; other site
290397007988	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
290397007989	oxyanion hole [active]
290397007990	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
290397007991	catalytic triad [active]
290397007992	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
290397007993	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
290397007994	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397007995	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397007996	acyl-activating enzyme (AAE) consensus motif; other site
290397007997	AMP binding site [chemical binding]; other site
290397007998	active site
290397007999	CoA binding site [chemical binding]; other site
290397008000	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
290397008001	active site
290397008002	catalytic triad [active]
290397008003	oxyanion hole [active]
290397008004	NAD synthetase; Reviewed; Region: nadE; PRK00876
290397008005	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
290397008006	NAD binding pocket [chemical binding]; other site
290397008007	ATP binding pocket [chemical binding]; other site
290397008008	Mg binding site [ion binding]; other site
290397008009	active-site loop [active]
290397008010	homodimer interface [polypeptide binding]; other site
290397008011	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
290397008012	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
290397008013	active site
290397008014	dimer interface [polypeptide binding]; other site
290397008015	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
290397008016	Ligand Binding Site [chemical binding]; other site
290397008017	Molecular Tunnel; other site
290397008018	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
290397008019	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
290397008020	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
290397008021	FAD binding pocket [chemical binding]; other site
290397008022	FAD binding motif [chemical binding]; other site
290397008023	phosphate binding motif [ion binding]; other site
290397008024	beta-alpha-beta structure motif; other site
290397008025	NAD binding pocket [chemical binding]; other site
290397008026	Iron coordination center [ion binding]; other site
290397008027	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397008028	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397008029	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
290397008030	diiron binding motif [ion binding]; other site
290397008031	Rhomboid family; Region: Rhomboid; pfam01694
290397008032	RNA polymerase sigma factor; Provisional; Region: PRK12518
290397008033	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397008034	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397008035	active site
290397008036	ATP binding site [chemical binding]; other site
290397008037	substrate binding site [chemical binding]; other site
290397008038	activation loop (A-loop); other site
290397008039	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
290397008040	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
290397008041	putative NAD(P) binding site [chemical binding]; other site
290397008042	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
290397008043	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
290397008044	cofactor binding site; other site
290397008045	metal binding site [ion binding]; metal-binding site
290397008046	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397008047	Walker A/P-loop; other site
290397008048	ATP binding site [chemical binding]; other site
290397008049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397008050	Walker A/P-loop; other site
290397008051	ATP binding site [chemical binding]; other site
290397008052	Q-loop/lid; other site
290397008053	ABC transporter signature motif; other site
290397008054	Walker B; other site
290397008055	D-loop; other site
290397008056	H-loop/switch region; other site
290397008057	Response regulator receiver domain; Region: Response_reg; pfam00072
290397008058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008059	active site
290397008060	phosphorylation site [posttranslational modification]
290397008061	intermolecular recognition site; other site
290397008062	dimerization interface [polypeptide binding]; other site
290397008063	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
290397008064	Na binding site [ion binding]; other site
290397008065	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
290397008067	dimer interface [polypeptide binding]; other site
290397008068	phosphorylation site [posttranslational modification]
290397008069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008070	ATP binding site [chemical binding]; other site
290397008071	Mg2+ binding site [ion binding]; other site
290397008072	G-X-G motif; other site
290397008073	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397008074	active site
290397008075	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290397008076	Resolvase, N terminal domain; Region: Resolvase; smart00857
290397008077	catalytic residues [active]
290397008078	catalytic nucleophile [active]
290397008079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
290397008080	Integrase core domain; Region: rve_3; pfam13683
290397008081	RHS Repeat; Region: RHS_repeat; pfam05593
290397008082	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
290397008083	Uncharacterized conserved protein [Function unknown]; Region: COG4198
290397008084	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
290397008085	chaperone protein DnaJ; Provisional; Region: PRK10767
290397008086	Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698
290397008087	NYN domain; Region: NYN; pfam01936
290397008088	putative metal binding site [ion binding]; other site
290397008089	Uncharacterized conserved protein [Function unknown]; Region: COG1432
290397008090	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
290397008091	short chain dehydrogenase; Provisional; Region: PRK06701
290397008092	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
290397008093	NAD binding site [chemical binding]; other site
290397008094	metal binding site [ion binding]; metal-binding site
290397008095	active site
290397008096	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
290397008097	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
290397008098	Domain of Unknown Function with PDB structure (DUF3864); Region: DUF3864; pfam12980
290397008099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008100	binding surface
290397008101	TPR motif; other site
290397008102	TPR repeat; Region: TPR_11; pfam13414
290397008103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008104	binding surface
290397008105	TPR motif; other site
290397008106	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
290397008107	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397008108	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
290397008109	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
290397008110	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
290397008111	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
290397008112	ATP binding site [chemical binding]; other site
290397008113	Walker A motif; other site
290397008114	hexamer interface [polypeptide binding]; other site
290397008115	Walker B motif; other site
290397008116	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
290397008117	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
290397008118	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
290397008119	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
290397008120	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
290397008121	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
290397008122	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
290397008123	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
290397008124	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
290397008125	TadE-like protein; Region: TadE; pfam07811
290397008126	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
290397008127	active site
290397008128	catalytic site [active]
290397008129	substrate binding site [chemical binding]; other site
290397008130	DNA topoisomerase VI subunit A; Provisional; Region: PRK04342
290397008131	Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406
290397008132	TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223
290397008133	active site
290397008134	metal binding site [ion binding]; metal-binding site
290397008135	interdomain interaction site; other site
290397008136	DNA topoisomerase VI subunit B; Validated; Region: PRK04184
290397008137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008138	ATP binding site [chemical binding]; other site
290397008139	Mg2+ binding site [ion binding]; other site
290397008140	G-X-G motif; other site
290397008141	TopoIIB_Trans: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIB family of DNA topoisomerases similar to Sulfolobus shibatae topoisomerase VI (topoVI). The sole representative of the Type IIB...; Region: TopoIIB_Trans; cd00823
290397008142	anchoring element; other site
290397008143	dimer interface [polypeptide binding]; other site
290397008144	ATP binding site [chemical binding]; other site
290397008145	Peptidase family M48; Region: Peptidase_M48; cl12018
290397008146	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
290397008147	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
290397008148	NAD(P) binding site [chemical binding]; other site
290397008149	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397008150	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
290397008151	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
290397008152	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
290397008153	EamA-like transporter family; Region: EamA; pfam00892
290397008154	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
290397008155	AzlC protein; Region: AzlC; cl00570
290397008156	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
290397008157	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
290397008158	DNA-binding site [nucleotide binding]; DNA binding site
290397008159	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397008160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397008161	homodimer interface [polypeptide binding]; other site
290397008162	catalytic residue [active]
290397008163	epoxyqueuosine reductase; Region: TIGR00276
290397008164	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
290397008165	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
290397008166	DNA methylase; Region: N6_N4_Mtase; cl17433
290397008167	DNA methylase; Region: N6_N4_Mtase; pfam01555
290397008168	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
290397008169	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
290397008170	active site
290397008171	Zn binding site [ion binding]; other site
290397008172	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
290397008173	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
290397008174	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
290397008175	nickel binding site [ion binding]; other site
290397008176	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290397008177	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
290397008178	putative dimer interface [polypeptide binding]; other site
290397008179	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
290397008180	Cysteine-rich domain; Region: CCG; pfam02754
290397008181	Cysteine-rich domain; Region: CCG; pfam02754
290397008182	FAD binding domain; Region: FAD_binding_4; pfam01565
290397008183	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290397008184	FAD binding domain; Region: FAD_binding_4; pfam01565
290397008185	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
290397008186	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
290397008187	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
290397008188	Fic/DOC family; Region: Fic; cl00960
290397008189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397008190	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397008191	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
290397008192	rRNA binding site [nucleotide binding]; other site
290397008193	predicted 30S ribosome binding site; other site
290397008194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
290397008195	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
290397008196	homotrimer interaction site [polypeptide binding]; other site
290397008197	putative active site [active]
290397008198	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397008199	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290397008200	DNA binding site [nucleotide binding]
290397008201	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
290397008202	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397008203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397008204	S-adenosylmethionine binding site [chemical binding]; other site
290397008205	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
290397008206	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
290397008207	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397008208	active site
290397008209	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290397008210	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397008211	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290397008212	acyl-activating enzyme (AAE) consensus motif; other site
290397008213	putative AMP binding site [chemical binding]; other site
290397008214	putative active site [active]
290397008215	putative CoA binding site [chemical binding]; other site
290397008216	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
290397008217	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397008218	Putative zinc-finger; Region: zf-HC2; pfam13490
290397008219	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
290397008220	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
290397008221	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
290397008222	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
290397008223	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
290397008224	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290397008225	catalytic core [active]
290397008226	Cupin domain; Region: Cupin_2; cl17218
290397008227	B12 binding domain; Region: B12-binding; pfam02310
290397008228	B12 binding site [chemical binding]; other site
290397008229	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290397008230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397008231	FeS/SAM binding site; other site
290397008232	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
290397008233	phosphate acetyltransferase; Reviewed; Region: PRK05632
290397008234	DRTGG domain; Region: DRTGG; pfam07085
290397008235	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
290397008236	propionate/acetate kinase; Provisional; Region: PRK12379
290397008237	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
290397008238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008239	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290397008240	NAD(P) binding site [chemical binding]; other site
290397008241	active site
290397008242	Helix-turn-helix domain; Region: HTH_17; pfam12728
290397008243	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290397008244	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
290397008245	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
290397008246	active site
290397008247	Cupin domain; Region: Cupin_2; cl17218
290397008248	Cytochrome c552; Region: Cytochrom_C552; pfam02335
290397008249	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
290397008250	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
290397008251	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
290397008252	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397008253	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397008254	acyl-activating enzyme (AAE) consensus motif; other site
290397008255	AMP binding site [chemical binding]; other site
290397008256	active site
290397008257	CoA binding site [chemical binding]; other site
290397008258	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
290397008259	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
290397008260	active site
290397008261	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
290397008262	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290397008263	active site
290397008264	catalytic site [active]
290397008265	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397008266	Protein of unknown function, DUF488; Region: DUF488; cl01246
290397008267	L,D-transpeptidase; Provisional; Region: PRK10260
290397008268	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397008269	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290397008270	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290397008271	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
290397008272	dimer interface [polypeptide binding]; other site
290397008273	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290397008274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008275	active site
290397008276	phosphorylation site [posttranslational modification]
290397008277	intermolecular recognition site; other site
290397008278	dimerization interface [polypeptide binding]; other site
290397008279	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397008280	DNA binding site [nucleotide binding]
290397008281	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008282	HAMP domain; Region: HAMP; pfam00672
290397008283	dimerization interface [polypeptide binding]; other site
290397008284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397008285	dimer interface [polypeptide binding]; other site
290397008286	phosphorylation site [posttranslational modification]
290397008287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008288	ATP binding site [chemical binding]; other site
290397008289	G-X-G motif; other site
290397008290	MarR family; Region: MarR_2; pfam12802
290397008291	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
290397008292	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
290397008293	Amidase; Region: Amidase; cl11426
290397008294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397008295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397008296	poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940
290397008297	N-glycosyltransferase; Provisional; Region: PRK11204
290397008298	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
290397008299	DXD motif; other site
290397008300	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
290397008301	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
290397008302	putative active site [active]
290397008303	putative metal binding site [ion binding]; other site
290397008304	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397008305	Peptidase family M48; Region: Peptidase_M48; cl12018
290397008306	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
290397008307	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
290397008308	ATP binding site [chemical binding]; other site
290397008309	substrate interface [chemical binding]; other site
290397008310	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
290397008311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397008312	Walker A motif; other site
290397008313	ATP binding site [chemical binding]; other site
290397008314	Walker B motif; other site
290397008315	Sfi1 spindle body protein; Region: Sfi1; pfam08457
290397008316	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
290397008317	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
290397008318	4Fe-4S binding domain; Region: Fer4; pfam00037
290397008319	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
290397008320	L-aspartate oxidase; Provisional; Region: PRK06175
290397008321	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290397008322	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
290397008323	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
290397008324	putative Iron-sulfur protein interface [polypeptide binding]; other site
290397008325	proximal heme binding site [chemical binding]; other site
290397008326	distal heme binding site [chemical binding]; other site
290397008327	putative dimer interface [polypeptide binding]; other site
290397008328	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
290397008329	Active site serine [active]
290397008330	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
290397008331	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
290397008332	PA/protease or protease-like domain interface [polypeptide binding]; other site
290397008333	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
290397008334	Zn binding site [ion binding]; other site
290397008335	PEGA domain; Region: PEGA; pfam08308
290397008336	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397008337	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397008338	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290397008339	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
290397008340	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
290397008341	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397008342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008344	Mg2+ binding site [ion binding]; other site
290397008345	G-X-G motif; other site
290397008346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008347	Response regulator receiver domain; Region: Response_reg; pfam00072
290397008348	active site
290397008349	phosphorylation site [posttranslational modification]
290397008350	intermolecular recognition site; other site
290397008351	dimerization interface [polypeptide binding]; other site
290397008352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397008353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008354	dimer interface [polypeptide binding]; other site
290397008355	phosphorylation site [posttranslational modification]
290397008356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008357	ATP binding site [chemical binding]; other site
290397008358	Mg2+ binding site [ion binding]; other site
290397008359	G-X-G motif; other site
290397008360	Response regulator receiver domain; Region: Response_reg; pfam00072
290397008361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008362	active site
290397008363	phosphorylation site [posttranslational modification]
290397008364	intermolecular recognition site; other site
290397008365	dimerization interface [polypeptide binding]; other site
290397008366	circadian clock protein KaiC; Reviewed; Region: PRK09302
290397008367	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397008368	Walker A motif; other site
290397008369	ATP binding site [chemical binding]; other site
290397008370	Walker B motif; other site
290397008371	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397008372	Walker A motif; other site
290397008373	ATP binding site [chemical binding]; other site
290397008374	Walker B motif; other site
290397008375	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
290397008376	putative hydrophobic ligand binding site [chemical binding]; other site
290397008377	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
290397008378	active site
290397008379	catalytic residues [active]
290397008380	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
290397008381	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
290397008382	active site
290397008383	DNA binding site [nucleotide binding]
290397008384	Int/Topo IB signature motif; other site
290397008385	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290397008386	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290397008387	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
290397008388	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290397008389	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290397008390	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290397008391	ATP binding site [chemical binding]; other site
290397008392	Mg++ binding site [ion binding]; other site
290397008393	motif III; other site
290397008394	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397008395	nucleotide binding region [chemical binding]; other site
290397008396	ATP-binding site [chemical binding]; other site
290397008397	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008399	ATP binding site [chemical binding]; other site
290397008400	Mg2+ binding site [ion binding]; other site
290397008401	G-X-G motif; other site
290397008402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008403	Response regulator receiver domain; Region: Response_reg; pfam00072
290397008404	active site
290397008405	phosphorylation site [posttranslational modification]
290397008406	intermolecular recognition site; other site
290397008407	dimerization interface [polypeptide binding]; other site
290397008408	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
290397008409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397008410	putative substrate translocation pore; other site
290397008411	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
290397008412	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
290397008413	putative ligand binding site [chemical binding]; other site
290397008414	putative NAD binding site [chemical binding]; other site
290397008415	putative catalytic site [active]
290397008416	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290397008417	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
290397008418	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397008419	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397008420	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
290397008421	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
290397008422	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397008423	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290397008424	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397008425	carboxyltransferase (CT) interaction site; other site
290397008426	biotinylation site [posttranslational modification]; other site
290397008427	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
290397008428	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
290397008429	Outer membrane efflux protein; Region: OEP; pfam02321
290397008430	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397008431	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290397008432	FtsX-like permease family; Region: FtsX; pfam02687
290397008433	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397008434	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397008435	Walker A/P-loop; other site
290397008436	ATP binding site [chemical binding]; other site
290397008437	Q-loop/lid; other site
290397008438	ABC transporter signature motif; other site
290397008439	Walker B; other site
290397008440	D-loop; other site
290397008441	H-loop/switch region; other site
290397008442	macrolide transporter subunit MacA; Provisional; Region: PRK11578
290397008443	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397008444	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397008445	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290397008446	FAD binding domain; Region: FAD_binding_4; pfam01565
290397008447	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
290397008448	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290397008449	L-lactate permease; Region: Lactate_perm; cl00701
290397008450	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
290397008451	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290397008452	Cysteine-rich domain; Region: CCG; pfam02754
290397008453	Cysteine-rich domain; Region: CCG; pfam02754
290397008454	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
290397008455	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
290397008456	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
290397008457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397008458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397008459	S-adenosylmethionine binding site [chemical binding]; other site
290397008460	TPR repeat; Region: TPR_11; pfam13414
290397008461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008462	binding surface
290397008463	TPR motif; other site
290397008464	Protein of unknown function, DUF399; Region: DUF399; pfam04187
290397008465	PilZ domain; Region: PilZ; pfam07238
290397008466	Predicted methyltransferase [General function prediction only]; Region: COG3897
290397008467	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290397008468	Uncharacterized conserved protein [Function unknown]; Region: COG3268
290397008469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008470	NAD(P) binding site [chemical binding]; other site
290397008471	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
290397008472	UPF0126 domain; Region: UPF0126; pfam03458
290397008473	Predicted membrane protein [Function unknown]; Region: COG2860
290397008474	UPF0126 domain; Region: UPF0126; pfam03458
290397008475	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
290397008476	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397008477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397008478	S-adenosylmethionine binding site [chemical binding]; other site
290397008479	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
290397008480	homodimer interface [polypeptide binding]; other site
290397008481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397008482	catalytic residue [active]
290397008483	Response regulator receiver domain; Region: Response_reg; pfam00072
290397008484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008485	active site
290397008486	phosphorylation site [posttranslational modification]
290397008487	intermolecular recognition site; other site
290397008488	dimerization interface [polypeptide binding]; other site
290397008489	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397008490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397008491	non-specific DNA binding site [nucleotide binding]; other site
290397008492	salt bridge; other site
290397008493	sequence-specific DNA binding site [nucleotide binding]; other site
290397008494	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
290397008495	Domain of unknown function (DUF955); Region: DUF955; pfam06114
290397008496	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
290397008497	malate synthase A; Region: malate_syn_A; TIGR01344
290397008498	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
290397008499	active site
290397008500	isocitrate lyase; Provisional; Region: PRK15063
290397008501	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
290397008502	tetramer interface [polypeptide binding]; other site
290397008503	active site
290397008504	Mg2+/Mn2+ binding site [ion binding]; other site
290397008505	Hemerythrin-like domain; Region: Hr-like; cd12108
290397008506	4-alpha-glucanotransferase; Provisional; Region: PRK14508
290397008507	trehalose synthase; Region: treS_nterm; TIGR02456
290397008508	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
290397008509	active site
290397008510	catalytic site [active]
290397008511	FOG: CBS domain [General function prediction only]; Region: COG0517
290397008512	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
290397008513	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
290397008514	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
290397008515	ligand binding site [chemical binding]; other site
290397008516	homodimer interface [polypeptide binding]; other site
290397008517	NAD(P) binding site [chemical binding]; other site
290397008518	trimer interface B [polypeptide binding]; other site
290397008519	trimer interface A [polypeptide binding]; other site
290397008520	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
290397008521	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
290397008522	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
290397008523	AMP-binding domain protein; Validated; Region: PRK08315
290397008524	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290397008525	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
290397008526	acyl-activating enzyme (AAE) consensus motif; other site
290397008527	acyl-activating enzyme (AAE) consensus motif; other site
290397008528	putative AMP binding site [chemical binding]; other site
290397008529	putative active site [active]
290397008530	putative CoA binding site [chemical binding]; other site
290397008531	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
290397008532	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
290397008533	NADP binding site [chemical binding]; other site
290397008534	dimer interface [polypeptide binding]; other site
290397008535	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
290397008536	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290397008537	TPP-binding site [chemical binding]; other site
290397008538	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
290397008539	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
290397008540	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290397008541	dimer interface [polypeptide binding]; other site
290397008542	PYR/PP interface [polypeptide binding]; other site
290397008543	TPP binding site [chemical binding]; other site
290397008544	substrate binding site [chemical binding]; other site
290397008545	pyruvate carboxylase; Reviewed; Region: PRK12999
290397008546	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397008547	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397008548	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290397008549	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
290397008550	active site
290397008551	catalytic residues [active]
290397008552	metal binding site [ion binding]; metal-binding site
290397008553	homodimer binding site [polypeptide binding]; other site
290397008554	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397008555	carboxyltransferase (CT) interaction site; other site
290397008556	biotinylation site [posttranslational modification]; other site
290397008557	Hemerythrin; Region: Hemerythrin; cd12107
290397008558	Fe binding site [ion binding]; other site
290397008559	Hemerythrin; Region: Hemerythrin; cd12107
290397008560	Fe binding site [ion binding]; other site
290397008561	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
290397008562	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290397008563	FAD binding domain; Region: FAD_binding_4; pfam01565
290397008564	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
290397008565	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290397008566	Cysteine-rich domain; Region: CCG; pfam02754
290397008567	glutamate dehydrogenase; Provisional; Region: PRK09414
290397008568	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
290397008569	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
290397008570	NAD(P) binding site [chemical binding]; other site
290397008571	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
290397008572	GAF domain; Region: GAF; cl17456
290397008573	GAF domain; Region: GAF_2; pfam13185
290397008574	GAF domain; Region: GAF; pfam01590
290397008575	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397008576	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397008577	active site
290397008578	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
290397008579	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
290397008580	NAD(P) binding site [chemical binding]; other site
290397008581	catalytic residues [active]
290397008582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008583	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
290397008584	NAD(P) binding site [chemical binding]; other site
290397008585	active site
290397008586	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
290397008587	Protein of unknown function (DUF523); Region: DUF523; pfam04463
290397008588	Uncharacterized conserved protein [Function unknown]; Region: COG3272
290397008589	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
290397008590	Predicted membrane protein [Function unknown]; Region: COG3671
290397008591	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
290397008592	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
290397008593	nucleotide binding site [chemical binding]; other site
290397008594	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290397008595	SBD interface [polypeptide binding]; other site
290397008596	DNA-K related protein; Region: DUF3731; pfam12531
290397008597	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
290397008598	nucleotide binding site [chemical binding]; other site
290397008599	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290397008600	SBD interface [polypeptide binding]; other site
290397008601	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
290397008602	Protein of unknown function DUF72; Region: DUF72; pfam01904
290397008603	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397008604	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397008605	active site
290397008606	catalytic tetrad [active]
290397008607	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
290397008608	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
290397008609	active site
290397008610	catalytic residues [active]
290397008611	metal binding site [ion binding]; metal-binding site
290397008612	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397008613	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397008614	active site
290397008615	catalytic tetrad [active]
290397008616	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
290397008617	intracellular protease, PfpI family; Region: PfpI; TIGR01382
290397008618	proposed catalytic triad [active]
290397008619	conserved cys residue [active]
290397008620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397008621	S-adenosylmethionine binding site [chemical binding]; other site
290397008622	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
290397008623	helicase 45; Provisional; Region: PTZ00424
290397008624	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290397008625	ATP binding site [chemical binding]; other site
290397008626	Mg++ binding site [ion binding]; other site
290397008627	motif III; other site
290397008628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397008629	nucleotide binding region [chemical binding]; other site
290397008630	ATP-binding site [chemical binding]; other site
290397008631	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
290397008632	RNA binding site [nucleotide binding]; other site
290397008633	Hemerythrin-like domain of FBXL5-like proteins; Region: Hr_FBXL5; cd12109
290397008634	Fe binding site [ion binding]; other site
290397008635	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290397008636	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397008637	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397008638	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
290397008639	putative deacylase active site [active]
290397008640	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290397008641	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
290397008642	metal-binding site
290397008643	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
290397008644	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
290397008645	Ligand binding site; other site
290397008646	Putative Catalytic site; other site
290397008647	DXD motif; other site
290397008648	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290397008649	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
290397008650	metal-binding site
290397008651	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
290397008652	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397008653	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
290397008654	putative ADP-binding pocket [chemical binding]; other site
290397008655	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
290397008656	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
290397008657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397008658	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
290397008659	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397008660	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290397008661	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290397008662	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
290397008663	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
290397008664	putative trimer interface [polypeptide binding]; other site
290397008665	putative CoA binding site [chemical binding]; other site
290397008666	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
290397008667	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
290397008668	inhibitor-cofactor binding pocket; inhibition site
290397008669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397008670	catalytic residue [active]
290397008671	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
290397008672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397008673	ZU5 domain; Region: ZU5; cl02517
290397008674	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
290397008675	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
290397008676	NHL repeat; Region: NHL; pfam01436
290397008677	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008678	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008679	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008680	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397008681	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008682	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008683	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008684	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008685	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
290397008686	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397008687	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008688	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008689	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008690	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008691	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008692	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
290397008693	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008694	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008695	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008696	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008697	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008698	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397008699	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290397008700	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290397008701	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
290397008702	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
290397008703	Uncharacterized conserved protein [Function unknown]; Region: COG3391
290397008704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008705	binding surface
290397008706	TPR motif; other site
290397008707	TPR repeat; Region: TPR_11; pfam13414
290397008708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008709	TPR repeat; Region: TPR_11; pfam13414
290397008710	binding surface
290397008711	TPR motif; other site
290397008712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008713	binding surface
290397008714	TPR motif; other site
290397008715	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397008716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397008717	binding surface
290397008718	TPR motif; other site
290397008719	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
290397008720	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
290397008721	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
290397008722	active site
290397008723	dimer interface [polypeptide binding]; other site
290397008724	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
290397008725	dimer interface [polypeptide binding]; other site
290397008726	active site
290397008727	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
290397008728	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290397008729	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
290397008730	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
290397008731	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
290397008732	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397008733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397008734	homodimer interface [polypeptide binding]; other site
290397008735	catalytic residue [active]
290397008736	argininosuccinate synthase; Validated; Region: PRK05370
290397008737	argininosuccinate synthase; Provisional; Region: PRK13820
290397008738	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
290397008739	4Fe-4S binding domain; Region: Fer4; cl02805
290397008740	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
290397008741	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290397008742	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
290397008743	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
290397008744	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
290397008745	PAS fold; Region: PAS; pfam00989
290397008746	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397008747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397008748	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397008749	Walker A motif; other site
290397008750	ATP binding site [chemical binding]; other site
290397008751	Walker B motif; other site
290397008752	arginine finger; other site
290397008753	Rubrerythrin [Energy production and conversion]; Region: COG1592
290397008754	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290397008755	binuclear metal center [ion binding]; other site
290397008756	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
290397008757	iron binding site [ion binding]; other site
290397008758	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397008759	dimerization interface [polypeptide binding]; other site
290397008760	putative DNA binding site [nucleotide binding]; other site
290397008761	putative Zn2+ binding site [ion binding]; other site
290397008762	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008763	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
290397008764	NAD(P) binding site [chemical binding]; other site
290397008765	active site
290397008766	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397008767	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397008768	active site
290397008769	catalytic tetrad [active]
290397008770	deoxyhypusine synthase; Region: dhys; TIGR00321
290397008771	Deoxyhypusine synthase; Region: DS; cl00826
290397008772	Deoxyhypusine synthase; Region: DS; cl00826
290397008773	Peptidase family M1; Region: Peptidase_M1; pfam01433
290397008774	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
290397008775	Zn binding site [ion binding]; other site
290397008776	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
290397008777	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397008778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397008779	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
290397008780	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
290397008781	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
290397008782	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
290397008783	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
290397008784	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
290397008785	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
290397008786	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290397008787	catalytic loop [active]
290397008788	iron binding site [ion binding]; other site
290397008789	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
290397008790	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
290397008791	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
290397008792	XdhC Rossmann domain; Region: XdhC_C; pfam13478
290397008793	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
290397008794	Ligand binding site; other site
290397008795	metal-binding site
290397008796	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
290397008797	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
290397008798	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
290397008799	active site
290397008800	metal binding site [ion binding]; metal-binding site
290397008801	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
290397008802	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
290397008803	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
290397008804	active site
290397008805	Zn binding site [ion binding]; other site
290397008806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397008807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397008808	dimer interface [polypeptide binding]; other site
290397008809	phosphorylation site [posttranslational modification]
290397008810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397008811	ATP binding site [chemical binding]; other site
290397008812	Mg2+ binding site [ion binding]; other site
290397008813	G-X-G motif; other site
290397008814	Outer membrane efflux protein; Region: OEP; pfam02321
290397008815	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397008816	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397008817	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
290397008818	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397008819	Walker A/P-loop; other site
290397008820	ATP binding site [chemical binding]; other site
290397008821	Q-loop/lid; other site
290397008822	ABC transporter signature motif; other site
290397008823	Walker B; other site
290397008824	D-loop; other site
290397008825	H-loop/switch region; other site
290397008826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397008827	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
290397008828	Walker A/P-loop; other site
290397008829	ATP binding site [chemical binding]; other site
290397008830	Q-loop/lid; other site
290397008831	ABC transporter signature motif; other site
290397008832	Walker B; other site
290397008833	D-loop; other site
290397008834	H-loop/switch region; other site
290397008835	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
290397008836	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
290397008837	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
290397008838	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
290397008839	Acetokinase family; Region: Acetate_kinase; cl17229
290397008840	propionate/acetate kinase; Provisional; Region: PRK12379
290397008841	putative phosphoketolase; Provisional; Region: PRK05261
290397008842	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
290397008843	TPP-binding site; other site
290397008844	XFP C-terminal domain; Region: XFP_C; pfam09363
290397008845	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
290397008846	Thioredoxin; Region: Thioredoxin_4; pfam13462
290397008847	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
290397008848	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
290397008849	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
290397008850	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
290397008851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397008852	Walker A/P-loop; other site
290397008853	ATP binding site [chemical binding]; other site
290397008854	Q-loop/lid; other site
290397008855	ABC transporter signature motif; other site
290397008856	Walker B; other site
290397008857	D-loop; other site
290397008858	H-loop/switch region; other site
290397008859	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
290397008860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397008861	dimer interface [polypeptide binding]; other site
290397008862	conserved gate region; other site
290397008863	putative PBP binding loops; other site
290397008864	ABC-ATPase subunit interface; other site
290397008865	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
290397008866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397008867	dimer interface [polypeptide binding]; other site
290397008868	conserved gate region; other site
290397008869	putative PBP binding loops; other site
290397008870	ABC-ATPase subunit interface; other site
290397008871	BON domain; Region: BON; cl02771
290397008872	RNA polymerase factor sigma-70; Validated; Region: PRK08241
290397008873	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397008874	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290397008875	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
290397008876	short chain dehydrogenase; Validated; Region: PRK05855
290397008877	DoxX-like family; Region: DoxX_2; pfam13564
290397008878	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
290397008879	Uncharacterized conserved protein [Function unknown]; Region: COG2128
290397008880	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
290397008881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397008882	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397008883	DNA binding residues [nucleotide binding]
290397008884	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397008885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397008886	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
290397008887	putative effector binding pocket; other site
290397008888	dimerization interface [polypeptide binding]; other site
290397008889	short chain dehydrogenase; Provisional; Region: PRK07041
290397008890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008891	NAD(P) binding site [chemical binding]; other site
290397008892	active site
290397008893	Hemin uptake protein hemP; Region: hemP; pfam10636
290397008894	GTPase RsgA; Reviewed; Region: PRK01889
290397008895	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
290397008896	GTPase/Zn-binding domain interface [polypeptide binding]; other site
290397008897	GTP/Mg2+ binding site [chemical binding]; other site
290397008898	G4 box; other site
290397008899	G5 box; other site
290397008900	G1 box; other site
290397008901	Switch I region; other site
290397008902	G2 box; other site
290397008903	G3 box; other site
290397008904	Switch II region; other site
290397008905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397008906	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397008907	active site
290397008908	phosphorylation site [posttranslational modification]
290397008909	intermolecular recognition site; other site
290397008910	dimerization interface [polypeptide binding]; other site
290397008911	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
290397008912	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
290397008913	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
290397008914	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
290397008915	active site
290397008916	Permease; Region: Permease; pfam02405
290397008917	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
290397008918	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
290397008919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397008920	Walker A/P-loop; other site
290397008921	ATP binding site [chemical binding]; other site
290397008922	Q-loop/lid; other site
290397008923	ABC transporter signature motif; other site
290397008924	Walker B; other site
290397008925	D-loop; other site
290397008926	H-loop/switch region; other site
290397008927	mce related protein; Region: MCE; pfam02470
290397008928	Protein of unknown function (DUF330); Region: DUF330; pfam03886
290397008929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397008930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397008931	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
290397008932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397008933	NAD(P) binding site [chemical binding]; other site
290397008934	active site
290397008935	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
290397008936	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290397008937	homodimer interface [polypeptide binding]; other site
290397008938	substrate-cofactor binding pocket; other site
290397008939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397008940	catalytic residue [active]
290397008941	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
290397008942	CHRD domain; Region: CHRD; cl06473
290397008943	CHRD domain; Region: CHRD; pfam07452
290397008944	CHRD domain; Region: CHRD; pfam07452
290397008945	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290397008946	iron-sulfur cluster [ion binding]; other site
290397008947	[2Fe-2S] cluster binding site [ion binding]; other site
290397008948	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
290397008949	iron-sulfur cluster [ion binding]; other site
290397008950	[2Fe-2S] cluster binding site [ion binding]; other site
290397008951	YceI-like domain; Region: YceI; pfam04264
290397008952	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397008953	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
290397008954	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
290397008955	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
290397008956	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
290397008957	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
290397008958	active site
290397008959	SAM binding site [chemical binding]; other site
290397008960	homodimer interface [polypeptide binding]; other site
290397008961	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
290397008962	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
290397008963	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
290397008964	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397008965	ligand binding site [chemical binding]; other site
290397008966	flexible hinge region; other site
290397008967	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
290397008968	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397008969	metal binding triad; other site
290397008970	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
290397008971	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
290397008972	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
290397008973	putative NAD(P) binding site [chemical binding]; other site
290397008974	active site
290397008975	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
290397008976	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397008977	dimer interface [polypeptide binding]; other site
290397008978	putative CheW interface [polypeptide binding]; other site
290397008979	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397008980	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
290397008981	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
290397008982	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
290397008983	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
290397008984	putative NAD(P) binding site [chemical binding]; other site
290397008985	putative substrate binding site [chemical binding]; other site
290397008986	catalytic Zn binding site [ion binding]; other site
290397008987	structural Zn binding site [ion binding]; other site
290397008988	dimer interface [polypeptide binding]; other site
290397008989	ABC-2 type transporter; Region: ABC2_membrane; cl17235
290397008990	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
290397008991	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
290397008992	Walker A/P-loop; other site
290397008993	ATP binding site [chemical binding]; other site
290397008994	Q-loop/lid; other site
290397008995	ABC transporter signature motif; other site
290397008996	Walker B; other site
290397008997	D-loop; other site
290397008998	H-loop/switch region; other site
290397008999	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
290397009000	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397009001	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397009002	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
290397009003	putative effector binding pocket; other site
290397009004	putative dimerization interface [polypeptide binding]; other site
290397009005	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
290397009006	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
290397009007	metal binding site [ion binding]; metal-binding site
290397009008	putative dimer interface [polypeptide binding]; other site
290397009009	UPF0126 domain; Region: UPF0126; pfam03458
290397009010	Predicted membrane protein [Function unknown]; Region: COG2860
290397009011	UPF0126 domain; Region: UPF0126; pfam03458
290397009012	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
290397009013	Prostaglandin dehydrogenases; Region: PGDH; cd05288
290397009014	NAD(P) binding site [chemical binding]; other site
290397009015	substrate binding site [chemical binding]; other site
290397009016	dimer interface [polypeptide binding]; other site
290397009017	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290397009018	DNA-binding site [nucleotide binding]; DNA binding site
290397009019	RNA-binding motif; other site
290397009020	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397009021	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290397009022	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
290397009023	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
290397009024	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290397009025	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397009026	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290397009027	Soluble P-type ATPase [General function prediction only]; Region: COG4087
290397009028	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290397009029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397009030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009031	dimer interface [polypeptide binding]; other site
290397009032	phosphorylation site [posttranslational modification]
290397009033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009034	Mg2+ binding site [ion binding]; other site
290397009035	G-X-G motif; other site
290397009036	circadian clock protein KaiC; Reviewed; Region: PRK09302
290397009037	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397009038	Walker A motif; other site
290397009039	ATP binding site [chemical binding]; other site
290397009040	Walker B motif; other site
290397009041	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397009042	ATP binding site [chemical binding]; other site
290397009043	Walker B motif; other site
290397009044	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
290397009045	CheB methylesterase; Region: CheB_methylest; pfam01339
290397009046	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
290397009047	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290397009048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397009049	S-adenosylmethionine binding site [chemical binding]; other site
290397009050	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290397009051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009052	dimer interface [polypeptide binding]; other site
290397009053	phosphorylation site [posttranslational modification]
290397009054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009055	ATP binding site [chemical binding]; other site
290397009056	Mg2+ binding site [ion binding]; other site
290397009057	G-X-G motif; other site
290397009058	Response regulator receiver domain; Region: Response_reg; pfam00072
290397009059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009060	active site
290397009061	phosphorylation site [posttranslational modification]
290397009062	intermolecular recognition site; other site
290397009063	dimerization interface [polypeptide binding]; other site
290397009064	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
290397009065	Putative glucoamylase; Region: Glycoamylase; pfam10091
290397009066	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
290397009067	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
290397009068	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
290397009069	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
290397009070	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
290397009071	PA/protease or protease-like domain interface [polypeptide binding]; other site
290397009072	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
290397009073	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
290397009074	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
290397009075	Uncharacterized conserved protein [Function unknown]; Region: COG2461
290397009076	Family of unknown function (DUF438); Region: DUF438; pfam04282
290397009077	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
290397009078	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
290397009079	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
290397009080	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
290397009081	dimer interface [polypeptide binding]; other site
290397009082	Domain of unknown function (DU1801); Region: DUF1801; cl17490
290397009083	RibD C-terminal domain; Region: RibD_C; cl17279
290397009084	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
290397009085	Predicted flavoprotein [General function prediction only]; Region: COG0431
290397009086	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290397009087	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
290397009088	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
290397009089	GAF domain; Region: GAF_3; pfam13492
290397009090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009091	Walker A motif; other site
290397009092	ATP binding site [chemical binding]; other site
290397009093	Walker B motif; other site
290397009094	arginine finger; other site
290397009095	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397009096	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
290397009097	Heavy-metal resistance; Region: Metal_resist; pfam13801
290397009098	dimer interface [polypeptide binding]; other site
290397009099	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397009100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397009101	S-adenosylmethionine binding site [chemical binding]; other site
290397009102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397009103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397009104	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
290397009105	putative effector binding pocket; other site
290397009106	putative dimerization interface [polypeptide binding]; other site
290397009107	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290397009108	classical (c) SDRs; Region: SDR_c; cd05233
290397009109	NAD(P) binding site [chemical binding]; other site
290397009110	active site
290397009111	short chain dehydrogenase; Provisional; Region: PRK06180
290397009112	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
290397009113	NADP binding site [chemical binding]; other site
290397009114	active site
290397009115	steroid binding site; other site
290397009116	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
290397009117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397009118	non-specific DNA binding site [nucleotide binding]; other site
290397009119	salt bridge; other site
290397009120	sequence-specific DNA binding site [nucleotide binding]; other site
290397009121	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
290397009122	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
290397009123	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
290397009124	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290397009125	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
290397009126	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397009127	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397009128	active site
290397009129	catalytic tetrad [active]
290397009130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397009131	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397009132	active site
290397009133	catalytic tetrad [active]
290397009134	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290397009135	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290397009136	NAD(P) binding site [chemical binding]; other site
290397009137	putative active site [active]
290397009138	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290397009139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397009140	NAD(P) binding site [chemical binding]; other site
290397009141	active site
290397009142	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397009143	active site
290397009144	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397009145	catalytic tetrad [active]
290397009146	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397009147	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
290397009148	putative effector binding pocket; other site
290397009149	putative dimerization interface [polypeptide binding]; other site
290397009150	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290397009151	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290397009152	Helix-turn-helix domain; Region: HTH_17; pfam12728
290397009153	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
290397009154	Part of AAA domain; Region: AAA_19; pfam13245
290397009155	Family description; Region: UvrD_C_2; pfam13538
290397009156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397009157	Walker A/P-loop; other site
290397009158	ATP binding site [chemical binding]; other site
290397009159	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
290397009160	putative active site [active]
290397009161	putative metal-binding site [ion binding]; other site
290397009162	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
290397009163	active site
290397009164	NTP binding site [chemical binding]; other site
290397009165	metal binding triad [ion binding]; metal-binding site
290397009166	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
290397009167	active site
290397009168	NTP binding site [chemical binding]; other site
290397009169	metal binding triad [ion binding]; metal-binding site
290397009170	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
290397009171	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
290397009172	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
290397009173	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
290397009174	P-loop containing region of AAA domain; Region: AAA_29; cl17516
290397009175	AAA domain; Region: AAA_23; pfam13476
290397009176	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
290397009177	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
290397009178	PglZ domain; Region: PglZ; pfam08665
290397009179	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290397009180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397009181	Replication-relaxation; Region: Replic_Relax; pfam13814
290397009182	DNA primase, catalytic core; Region: dnaG; TIGR01391
290397009183	CHC2 zinc finger; Region: zf-CHC2; cl17510
290397009184	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
290397009185	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
290397009186	active site
290397009187	metal binding site [ion binding]; metal-binding site
290397009188	interdomain interaction site; other site
290397009189	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
290397009190	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
290397009191	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
290397009192	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
290397009193	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397009194	Protein kinase domain; Region: Pkinase; pfam00069
290397009195	active site
290397009196	ATP binding site [chemical binding]; other site
290397009197	substrate binding site [chemical binding]; other site
290397009198	activation loop (A-loop); other site
290397009199	Protein of unknown function (DUF2381); Region: DUF2381; pfam09544
290397009200	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
290397009201	AAA-like domain; Region: AAA_10; pfam12846
290397009202	hypothetical protein; Reviewed; Region: PRK00024
290397009203	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290397009204	MPN+ (JAMM) motif; other site
290397009205	Zinc-binding site [ion binding]; other site
290397009206	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
290397009207	metal ion-dependent adhesion site (MIDAS); other site
290397009208	MoxR-like ATPases [General function prediction only]; Region: COG0714
290397009209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009210	Walker A motif; other site
290397009211	ATP binding site [chemical binding]; other site
290397009212	Walker B motif; other site
290397009213	arginine finger; other site
290397009214	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
290397009215	ParB-like nuclease domain; Region: ParB; smart00470
290397009216	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
290397009217	Part of AAA domain; Region: AAA_19; pfam13245
290397009218	Family description; Region: UvrD_C_2; pfam13538
290397009219	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
290397009220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397009221	Walker A/P-loop; other site
290397009222	ATP binding site [chemical binding]; other site
290397009223	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
290397009224	putative active site [active]
290397009225	putative metal-binding site [ion binding]; other site
290397009226	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
290397009227	ParB-like nuclease domain; Region: ParB; smart00470
290397009228	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290397009229	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397009230	P-loop; other site
290397009231	Magnesium ion binding site [ion binding]; other site
290397009232	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397009233	Magnesium ion binding site [ion binding]; other site
290397009234	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
290397009235	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397009236	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397009237	catalytic residue [active]
290397009238	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
290397009239	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290397009240	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
290397009241	proline aminopeptidase P II; Provisional; Region: PRK10879
290397009242	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
290397009243	active site
290397009244	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
290397009245	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
290397009246	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
290397009247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
290397009248	Bacterial transcriptional activator domain; Region: BTAD; smart01043
290397009249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290397009250	TPR motif; other site
290397009251	binding surface
290397009252	AAA ATPase domain; Region: AAA_16; pfam13191
290397009253	FeoA domain; Region: FeoA; pfam04023
290397009254	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
290397009255	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
290397009256	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
290397009257	G1 box; other site
290397009258	GTP/Mg2+ binding site [chemical binding]; other site
290397009259	Switch I region; other site
290397009260	G2 box; other site
290397009261	G3 box; other site
290397009262	Switch II region; other site
290397009263	G4 box; other site
290397009264	G5 box; other site
290397009265	Nucleoside recognition; Region: Gate; pfam07670
290397009266	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
290397009267	Nucleoside recognition; Region: Gate; pfam07670
290397009268	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
290397009269	NAD(P) binding site [chemical binding]; other site
290397009270	ferredoxin-NADP+ reductase; Region: PLN02852
290397009271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397009272	Uncharacterized conserved protein [Function unknown]; Region: COG3791
290397009273	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
290397009274	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
290397009275	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
290397009276	Multicopper oxidase; Region: Cu-oxidase; pfam00394
290397009277	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
290397009278	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
290397009279	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290397009280	dimer interface [polypeptide binding]; other site
290397009281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397009282	catalytic residue [active]
290397009283	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
290397009284	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
290397009285	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
290397009286	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
290397009287	Peptidase family M48; Region: Peptidase_M48; cl12018
290397009288	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
290397009289	signal recognition particle protein; Provisional; Region: PRK10867
290397009290	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
290397009291	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290397009292	P loop; other site
290397009293	GTP binding site [chemical binding]; other site
290397009294	Signal peptide binding domain; Region: SRP_SPB; pfam02978
290397009295	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
290397009296	putative ligand binding pocket/active site [active]
290397009297	putative metal binding site [ion binding]; other site
290397009298	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
290397009299	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
290397009300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009301	TPR motif; other site
290397009302	binding surface
290397009303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009304	binding surface
290397009305	TPR motif; other site
290397009306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290397009307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009308	binding surface
290397009309	TPR motif; other site
290397009310	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
290397009311	TMP-binding site; other site
290397009312	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
290397009313	putative active site; other site
290397009314	putative metal binding residues [ion binding]; other site
290397009315	signature motif; other site
290397009316	putative triphosphate binding site [ion binding]; other site
290397009317	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397009318	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397009319	active site
290397009320	metal binding site [ion binding]; metal-binding site
290397009321	CotH protein; Region: CotH; pfam08757
290397009322	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397009323	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397009324	phosphopeptide binding site; other site
290397009325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009326	binding surface
290397009327	TPR motif; other site
290397009328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009329	binding surface
290397009330	TPR motif; other site
290397009331	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
290397009332	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
290397009333	Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266
290397009334	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397009335	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
290397009336	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
290397009337	Phosphotransferase enzyme family; Region: APH; pfam01636
290397009338	putative active site [active]
290397009339	putative substrate binding site [chemical binding]; other site
290397009340	ATP binding site [chemical binding]; other site
290397009341	TPR repeat; Region: TPR_11; pfam13414
290397009342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009343	binding surface
290397009344	TPR motif; other site
290397009345	TPR repeat; Region: TPR_11; pfam13414
290397009346	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009347	binding surface
290397009348	TPR motif; other site
290397009349	TPR repeat; Region: TPR_11; pfam13414
290397009350	TPR repeat; Region: TPR_11; pfam13414
290397009351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009352	binding surface
290397009353	TPR motif; other site
290397009354	FHA domain; Region: FHA; pfam00498
290397009355	phosphopeptide binding site; other site
290397009356	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397009357	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397009358	phosphopeptide binding site; other site
290397009359	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290397009360	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009361	Walker A motif; other site
290397009362	ATP binding site [chemical binding]; other site
290397009363	Walker B motif; other site
290397009364	arginine finger; other site
290397009365	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397009366	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397009367	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
290397009368	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290397009369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397009370	ligand binding site [chemical binding]; other site
290397009371	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397009372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009373	active site
290397009374	phosphorylation site [posttranslational modification]
290397009375	intermolecular recognition site; other site
290397009376	dimerization interface [polypeptide binding]; other site
290397009377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009378	Walker A motif; other site
290397009379	ATP binding site [chemical binding]; other site
290397009380	Walker B motif; other site
290397009381	arginine finger; other site
290397009382	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397009383	Transglycosylase; Region: Transgly; pfam00912
290397009384	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
290397009385	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
290397009386	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
290397009387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009388	dimer interface [polypeptide binding]; other site
290397009389	phosphorylation site [posttranslational modification]
290397009390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009391	ATP binding site [chemical binding]; other site
290397009392	Mg2+ binding site [ion binding]; other site
290397009393	G-X-G motif; other site
290397009394	Peptidase S46; Region: Peptidase_S46; pfam10459
290397009395	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290397009396	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
290397009397	quinolinate synthetase; Provisional; Region: PRK09375
290397009398	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397009399	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397009400	active site
290397009401	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
290397009402	Found in ATP-dependent protease La (LON); Region: LON; smart00464
290397009403	Found in ATP-dependent protease La (LON); Region: LON; smart00464
290397009404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009405	Walker A motif; other site
290397009406	ATP binding site [chemical binding]; other site
290397009407	Walker B motif; other site
290397009408	arginine finger; other site
290397009409	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
290397009410	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
290397009411	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397009412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397009413	catalytic residue [active]
290397009414	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
290397009415	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
290397009416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009417	Walker A motif; other site
290397009418	ATP binding site [chemical binding]; other site
290397009419	Walker B motif; other site
290397009420	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290397009421	Clp protease; Region: CLP_protease; pfam00574
290397009422	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
290397009423	oligomer interface [polypeptide binding]; other site
290397009424	active site residues [active]
290397009425	trigger factor; Region: tig; TIGR00115
290397009426	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290397009427	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
290397009428	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
290397009429	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
290397009430	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578
290397009431	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
290397009432	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290397009433	Ligand binding site; other site
290397009434	Putative Catalytic site; other site
290397009435	DXD motif; other site
290397009436	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
290397009437	active site
290397009438	dimerization interface [polypeptide binding]; other site
290397009439	ribonuclease PH; Reviewed; Region: rph; PRK00173
290397009440	Ribonuclease PH; Region: RNase_PH_bact; cd11362
290397009441	hexamer interface [polypeptide binding]; other site
290397009442	active site
290397009443	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
290397009444	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
290397009445	active site
290397009446	metal binding site [ion binding]; metal-binding site
290397009447	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
290397009448	dimerization interface [polypeptide binding]; other site
290397009449	putative ATP binding site [chemical binding]; other site
290397009450	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009451	binding surface
290397009452	TPR motif; other site
290397009453	TPR repeat; Region: TPR_11; pfam13414
290397009454	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290397009455	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009456	binding surface
290397009457	TPR motif; other site
290397009458	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
290397009459	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
290397009460	RecX family; Region: RecX; cl00936
290397009461	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
290397009462	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397009463	ATP binding site [chemical binding]; other site
290397009464	Walker B motif; other site
290397009465	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
290397009466	PLD-like domain; Region: PLDc_2; pfam13091
290397009467	putative active site [active]
290397009468	catalytic site [active]
290397009469	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
290397009470	PLD-like domain; Region: PLDc_2; pfam13091
290397009471	putative active site [active]
290397009472	catalytic site [active]
290397009473	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
290397009474	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
290397009475	23S rRNA interface [nucleotide binding]; other site
290397009476	L3 interface [polypeptide binding]; other site
290397009477	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
290397009478	Part of AAA domain; Region: AAA_19; pfam13245
290397009479	Family description; Region: UvrD_C_2; pfam13538
290397009480	DoxX; Region: DoxX; pfam07681
290397009481	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
290397009482	CGNR zinc finger; Region: zf-CGNR; pfam11706
290397009483	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
290397009484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397009485	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397009486	putative substrate translocation pore; other site
290397009487	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397009488	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397009489	active site
290397009490	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
290397009491	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
290397009492	putative C-terminal domain interface [polypeptide binding]; other site
290397009493	putative GSH binding site (G-site) [chemical binding]; other site
290397009494	putative dimer interface [polypeptide binding]; other site
290397009495	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
290397009496	N-terminal domain interface [polypeptide binding]; other site
290397009497	dimer interface [polypeptide binding]; other site
290397009498	substrate binding pocket (H-site) [chemical binding]; other site
290397009499	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397009500	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290397009501	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397009502	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290397009503	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290397009504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397009505	dimerization interface [polypeptide binding]; other site
290397009506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009507	dimer interface [polypeptide binding]; other site
290397009508	phosphorylation site [posttranslational modification]
290397009509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009510	ATP binding site [chemical binding]; other site
290397009511	Mg2+ binding site [ion binding]; other site
290397009512	G-X-G motif; other site
290397009513	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397009514	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
290397009515	Walker A/P-loop; other site
290397009516	ATP binding site [chemical binding]; other site
290397009517	Q-loop/lid; other site
290397009518	ABC transporter signature motif; other site
290397009519	Walker B; other site
290397009520	D-loop; other site
290397009521	H-loop/switch region; other site
290397009522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397009523	Walker A/P-loop; other site
290397009524	ATP binding site [chemical binding]; other site
290397009525	Q-loop/lid; other site
290397009526	ABC transporter signature motif; other site
290397009527	Walker B; other site
290397009528	D-loop; other site
290397009529	H-loop/switch region; other site
290397009530	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290397009531	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397009532	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290397009533	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
290397009534	active site
290397009535	dimerization interface [polypeptide binding]; other site
290397009536	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
290397009537	putative active site [active]
290397009538	Zn binding site [ion binding]; other site
290397009539	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290397009540	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397009541	catalytic residues [active]
290397009542	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
290397009543	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
290397009544	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290397009545	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290397009546	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397009547	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
290397009548	Beta-lactamase; Region: Beta-lactamase; pfam00144
290397009549	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
290397009550	dimer interface [polypeptide binding]; other site
290397009551	catalytic triad [active]
290397009552	acetyl-CoA synthetase; Provisional; Region: PRK00174
290397009553	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
290397009554	active site
290397009555	CoA binding site [chemical binding]; other site
290397009556	acyl-activating enzyme (AAE) consensus motif; other site
290397009557	AMP binding site [chemical binding]; other site
290397009558	acetate binding site [chemical binding]; other site
290397009559	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290397009560	Domain of unknown function DUF20; Region: UPF0118; pfam01594
290397009561	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
290397009562	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
290397009563	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290397009564	glutathione S-transferase; Provisional; Region: PRK15113
290397009565	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
290397009566	C-terminal domain interface [polypeptide binding]; other site
290397009567	GSH binding site (G-site) [chemical binding]; other site
290397009568	dimer interface [polypeptide binding]; other site
290397009569	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
290397009570	N-terminal domain interface [polypeptide binding]; other site
290397009571	putative dimer interface [polypeptide binding]; other site
290397009572	putative substrate binding pocket (H-site) [chemical binding]; other site
290397009573	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290397009574	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397009575	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397009576	dimer interface [polypeptide binding]; other site
290397009577	putative CheW interface [polypeptide binding]; other site
290397009578	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
290397009579	Protein of unknown function, DUF481; Region: DUF481; pfam04338
290397009580	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397009581	ATP binding site [chemical binding]; other site
290397009582	putative Mg++ binding site [ion binding]; other site
290397009583	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397009584	nucleotide binding region [chemical binding]; other site
290397009585	ATP-binding site [chemical binding]; other site
290397009586	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
290397009587	Uncharacterized conserved protein [Function unknown]; Region: COG4095
290397009588	Protein of unknown function, DUF488; Region: DUF488; pfam04343
290397009589	RF-1 domain; Region: RF-1; pfam00472
290397009590	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397009591	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397009592	Walker A/P-loop; other site
290397009593	ATP binding site [chemical binding]; other site
290397009594	Q-loop/lid; other site
290397009595	ABC transporter signature motif; other site
290397009596	Walker B; other site
290397009597	D-loop; other site
290397009598	H-loop/switch region; other site
290397009599	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290397009600	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397009601	FtsX-like permease family; Region: FtsX; pfam02687
290397009602	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397009603	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
290397009604	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
290397009605	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
290397009606	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
290397009607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009608	binding surface
290397009609	TPR motif; other site
290397009610	TPR repeat; Region: TPR_11; pfam13414
290397009611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009612	binding surface
290397009613	TPR motif; other site
290397009614	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
290397009615	Protein of unknown function, DUF482; Region: DUF482; pfam04339
290397009616	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
290397009617	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
290397009618	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
290397009619	maleylacetoacetate isomerase; Region: maiA; TIGR01262
290397009620	C-terminal domain interface [polypeptide binding]; other site
290397009621	GSH binding site (G-site) [chemical binding]; other site
290397009622	putative dimer interface [polypeptide binding]; other site
290397009623	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
290397009624	dimer interface [polypeptide binding]; other site
290397009625	N-terminal domain interface [polypeptide binding]; other site
290397009626	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
290397009627	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
290397009628	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
290397009629	dimer interface [polypeptide binding]; other site
290397009630	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
290397009631	active site
290397009632	Fe binding site [ion binding]; other site
290397009633	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
290397009634	alanine racemase; Reviewed; Region: alr; PRK00053
290397009635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
290397009636	active site
290397009637	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290397009638	dimer interface [polypeptide binding]; other site
290397009639	substrate binding site [chemical binding]; other site
290397009640	catalytic residues [active]
290397009641	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
290397009642	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
290397009643	homodimer interface [polypeptide binding]; other site
290397009644	substrate-cofactor binding pocket; other site
290397009645	catalytic residue [active]
290397009646	MarR family; Region: MarR_2; pfam12802
290397009647	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290397009648	dimer interface [polypeptide binding]; other site
290397009649	motif 1; other site
290397009650	active site
290397009651	motif 2; other site
290397009652	motif 3; other site
290397009653	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
290397009654	amidase; Provisional; Region: PRK07869
290397009655	Amidase; Region: Amidase; cl11426
290397009656	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290397009657	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
290397009658	TrkA-C domain; Region: TrkA_C; pfam02080
290397009659	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290397009660	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
290397009661	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
290397009662	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
290397009663	active site
290397009664	Zn binding site [ion binding]; other site
290397009665	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
290397009666	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
290397009667	cofactor binding site; other site
290397009668	DNA binding site [nucleotide binding]
290397009669	substrate interaction site [chemical binding]; other site
290397009670	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
290397009671	additional DNA contacts [nucleotide binding]; other site
290397009672	mismatch recognition site; other site
290397009673	active site
290397009674	zinc binding site [ion binding]; other site
290397009675	DNA intercalation site [nucleotide binding]; other site
290397009676	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
290397009677	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
290397009678	active site
290397009679	PHP Thumb interface [polypeptide binding]; other site
290397009680	metal binding site [ion binding]; metal-binding site
290397009681	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
290397009682	generic binding surface II; other site
290397009683	generic binding surface I; other site
290397009684	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290397009685	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397009686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290397009687	DNA binding residues [nucleotide binding]
290397009688	dimerization interface [polypeptide binding]; other site
290397009689	threonine dehydratase; Provisional; Region: PRK08198
290397009690	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
290397009691	tetramer interface [polypeptide binding]; other site
290397009692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397009693	catalytic residue [active]
290397009694	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
290397009695	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397009696	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397009697	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397009698	active site
290397009699	ATP binding site [chemical binding]; other site
290397009700	substrate binding site [chemical binding]; other site
290397009701	activation loop (A-loop); other site
290397009702	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290397009703	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
290397009704	structural tetrad; other site
290397009705	PQQ-like domain; Region: PQQ_2; pfam13360
290397009706	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290397009707	structural tetrad; other site
290397009708	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290397009709	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290397009710	structural tetrad; other site
290397009711	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
290397009712	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290397009713	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397009714	catalytic residue [active]
290397009715	biotin synthase; Region: bioB; TIGR00433
290397009716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397009717	FeS/SAM binding site; other site
290397009718	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
290397009719	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
290397009720	DNA repair protein RadA; Provisional; Region: PRK11823
290397009721	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
290397009722	Walker A motif; other site
290397009723	ATP binding site [chemical binding]; other site
290397009724	Walker B motif; other site
290397009725	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290397009726	glycerol kinase; Provisional; Region: glpK; PRK00047
290397009727	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
290397009728	N- and C-terminal domain interface [polypeptide binding]; other site
290397009729	active site
290397009730	MgATP binding site [chemical binding]; other site
290397009731	catalytic site [active]
290397009732	metal binding site [ion binding]; metal-binding site
290397009733	glycerol binding site [chemical binding]; other site
290397009734	homotetramer interface [polypeptide binding]; other site
290397009735	homodimer interface [polypeptide binding]; other site
290397009736	FBP binding site [chemical binding]; other site
290397009737	protein IIAGlc interface [polypeptide binding]; other site
290397009738	Esterase/lipase [General function prediction only]; Region: COG1647
290397009739	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
290397009740	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
290397009741	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
290397009742	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
290397009743	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290397009744	Stigma-specific protein, Stig1; Region: Stig1; pfam04885
290397009745	Uncharacterized conserved protein [Function unknown]; Region: COG3391
290397009746	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
290397009747	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290397009748	intersubunit interface [polypeptide binding]; other site
290397009749	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
290397009750	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290397009751	dimer interface [polypeptide binding]; other site
290397009752	putative PBP binding regions; other site
290397009753	ABC-ATPase subunit  interface; other site
290397009754	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290397009755	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290397009756	Walker A/P-loop; other site
290397009757	ATP binding site [chemical binding]; other site
290397009758	Q-loop/lid; other site
290397009759	ABC transporter signature motif; other site
290397009760	Walker B; other site
290397009761	D-loop; other site
290397009762	H-loop/switch region; other site
290397009763	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
290397009764	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
290397009765	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
290397009766	active site
290397009767	tetramer interface; other site
290397009768	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397009769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009770	active site
290397009771	phosphorylation site [posttranslational modification]
290397009772	intermolecular recognition site; other site
290397009773	dimerization interface [polypeptide binding]; other site
290397009774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397009775	Walker A motif; other site
290397009776	ATP binding site [chemical binding]; other site
290397009777	Walker B motif; other site
290397009778	arginine finger; other site
290397009779	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397009780	Response regulator receiver domain; Region: Response_reg; pfam00072
290397009781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009782	active site
290397009783	phosphorylation site [posttranslational modification]
290397009784	intermolecular recognition site; other site
290397009785	dimerization interface [polypeptide binding]; other site
290397009786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009787	dimer interface [polypeptide binding]; other site
290397009788	phosphorylation site [posttranslational modification]
290397009789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009790	ATP binding site [chemical binding]; other site
290397009791	G-X-G motif; other site
290397009792	Response regulator receiver domain; Region: Response_reg; pfam00072
290397009793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009794	active site
290397009795	phosphorylation site [posttranslational modification]
290397009796	intermolecular recognition site; other site
290397009797	dimerization interface [polypeptide binding]; other site
290397009798	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397009799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397009800	metal binding site [ion binding]; metal-binding site
290397009801	active site
290397009802	I-site; other site
290397009803	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
290397009804	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
290397009805	pteridine reductase; Provisional; Region: PRK09135
290397009806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397009807	NAD(P) binding site [chemical binding]; other site
290397009808	active site
290397009809	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
290397009810	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
290397009811	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
290397009812	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
290397009813	NAD binding site [chemical binding]; other site
290397009814	homotetramer interface [polypeptide binding]; other site
290397009815	homodimer interface [polypeptide binding]; other site
290397009816	substrate binding site [chemical binding]; other site
290397009817	active site
290397009818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009819	TPR motif; other site
290397009820	binding surface
290397009821	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
290397009822	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
290397009823	GTP binding site; other site
290397009824	camphor resistance protein CrcB; Provisional; Region: PRK14208
290397009825	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
290397009826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397009827	S-adenosylmethionine binding site [chemical binding]; other site
290397009828	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
290397009829	Pirin-related protein [General function prediction only]; Region: COG1741
290397009830	Pirin; Region: Pirin; pfam02678
290397009831	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
290397009832	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
290397009833	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
290397009834	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
290397009835	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
290397009836	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
290397009837	MPN+ (JAMM) motif; other site
290397009838	Zinc-binding site [ion binding]; other site
290397009839	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
290397009840	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
290397009841	ATP binding site [chemical binding]; other site
290397009842	substrate interface [chemical binding]; other site
290397009843	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290397009844	active site residue [active]
290397009845	Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977
290397009846	charged pocket; other site
290397009847	hydrophobic patch; other site
290397009848	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
290397009849	putative homodimer interface [polypeptide binding]; other site
290397009850	putative homotetramer interface [polypeptide binding]; other site
290397009851	putative allosteric switch controlling residues; other site
290397009852	putative metal binding site [ion binding]; other site
290397009853	putative homodimer-homodimer interface [polypeptide binding]; other site
290397009854	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
290397009855	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
290397009856	metal-binding site [ion binding]
290397009857	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290397009858	Soluble P-type ATPase [General function prediction only]; Region: COG4087
290397009859	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
290397009860	SnoaL-like domain; Region: SnoaL_3; pfam13474
290397009861	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
290397009862	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397009863	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397009864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
290397009865	Phosphoesterase family; Region: Phosphoesterase; pfam04185
290397009866	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397009867	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397009868	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397009869	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
290397009870	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290397009871	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290397009872	active site
290397009873	catalytic tetrad [active]
290397009874	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290397009875	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290397009876	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290397009877	dimerization interface [polypeptide binding]; other site
290397009878	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290397009879	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397009880	catalytic residues [active]
290397009881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
290397009882	putative lipid kinase; Reviewed; Region: PRK13057
290397009883	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
290397009884	Hemerythrin-like domain; Region: Hr-like; cd12108
290397009885	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397009886	dimerization interface [polypeptide binding]; other site
290397009887	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397009888	dimer interface [polypeptide binding]; other site
290397009889	putative CheW interface [polypeptide binding]; other site
290397009890	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
290397009891	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397009892	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397009893	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290397009894	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290397009895	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397009896	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
290397009897	IMP binding site; other site
290397009898	dimer interface [polypeptide binding]; other site
290397009899	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
290397009900	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
290397009901	active site residue [active]
290397009902	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
290397009903	active site residue [active]
290397009904	Response regulator receiver domain; Region: Response_reg; pfam00072
290397009905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009906	active site
290397009907	phosphorylation site [posttranslational modification]
290397009908	intermolecular recognition site; other site
290397009909	dimerization interface [polypeptide binding]; other site
290397009910	HEAT repeats; Region: HEAT_2; pfam13646
290397009911	Domain of unknown function (DUF4042); Region: DUF4042; pfam13251
290397009912	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
290397009913	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
290397009914	DXD motif; other site
290397009915	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
290397009916	HflK protein; Region: hflK; TIGR01933
290397009917	HflC protein; Region: hflC; TIGR01932
290397009918	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
290397009919	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
290397009920	active site
290397009921	catalytic triad [active]
290397009922	CARDB; Region: CARDB; pfam07705
290397009923	CARDB; Region: CARDB; pfam07705
290397009924	CARDB; Region: CARDB; pfam07705
290397009925	CARDB; Region: CARDB; pfam07705
290397009926	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290397009927	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397009928	non-specific DNA binding site [nucleotide binding]; other site
290397009929	salt bridge; other site
290397009930	sequence-specific DNA binding site [nucleotide binding]; other site
290397009931	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
290397009932	putative NAD(P) binding site [chemical binding]; other site
290397009933	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
290397009934	PAS fold; Region: PAS_4; pfam08448
290397009935	PAS domain S-box; Region: sensory_box; TIGR00229
290397009936	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397009937	putative active site [active]
290397009938	heme pocket [chemical binding]; other site
290397009939	PAS domain; Region: PAS; smart00091
290397009940	PAS fold; Region: PAS_4; pfam08448
290397009941	PAS domain S-box; Region: sensory_box; TIGR00229
290397009942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397009943	putative active site [active]
290397009944	heme pocket [chemical binding]; other site
290397009945	PAS domain S-box; Region: sensory_box; TIGR00229
290397009946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397009947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009948	dimer interface [polypeptide binding]; other site
290397009949	phosphorylation site [posttranslational modification]
290397009950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009951	ATP binding site [chemical binding]; other site
290397009952	Mg2+ binding site [ion binding]; other site
290397009953	G-X-G motif; other site
290397009954	Response regulator receiver domain; Region: Response_reg; pfam00072
290397009955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397009956	active site
290397009957	phosphorylation site [posttranslational modification]
290397009958	intermolecular recognition site; other site
290397009959	dimerization interface [polypeptide binding]; other site
290397009960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397009961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397009962	dimer interface [polypeptide binding]; other site
290397009963	phosphorylation site [posttranslational modification]
290397009964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397009965	ATP binding site [chemical binding]; other site
290397009966	Mg2+ binding site [ion binding]; other site
290397009967	G-X-G motif; other site
290397009968	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
290397009969	Peptidase family M48; Region: Peptidase_M48; cl12018
290397009970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290397009971	non-specific DNA binding site [nucleotide binding]; other site
290397009972	salt bridge; other site
290397009973	sequence-specific DNA binding site [nucleotide binding]; other site
290397009974	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
290397009975	HNH endonuclease; Region: HNH_2; pfam13391
290397009976	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
290397009977	Mrr N-terminal domain; Region: Mrr_N; pfam14338
290397009978	Restriction endonuclease; Region: Mrr_cat; pfam04471
290397009979	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
290397009980	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
290397009981	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290397009982	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
290397009983	EcsC protein family; Region: EcsC; pfam12787
290397009984	HNH endonuclease; Region: HNH_3; pfam13392
290397009985	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
290397009986	Phage integrase family; Region: Phage_integrase; pfam00589
290397009987	active site
290397009988	DNA binding site [nucleotide binding]
290397009989	Int/Topo IB signature motif; other site
290397009990	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290397009991	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
290397009992	putative active site [active]
290397009993	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
290397009994	TPR repeat; Region: TPR_11; pfam13414
290397009995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397009996	TPR motif; other site
290397009997	binding surface
290397009998	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397009999	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
290397010000	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
290397010001	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397010002	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397010003	catalytic residue [active]
290397010004	L-aspartate oxidase; Provisional; Region: PRK06175
290397010005	L-aspartate oxidase; Provisional; Region: PRK09077
290397010006	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290397010007	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397010008	active site
290397010009	ParB-like nuclease domain; Region: ParBc; cl02129
290397010010	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
290397010011	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
290397010012	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
290397010013	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397010014	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
290397010015	DNA binding residues [nucleotide binding]
290397010016	nitrilase; Region: PLN02798
290397010017	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
290397010018	putative active site [active]
290397010019	catalytic triad [active]
290397010020	dimer interface [polypeptide binding]; other site
290397010021	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
290397010022	Interdomain contacts; other site
290397010023	Cytokine receptor motif; other site
290397010024	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290397010025	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
290397010026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397010027	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
290397010028	NAD(P) binding site [chemical binding]; other site
290397010029	active site
290397010030	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
290397010031	Peptidase family M50; Region: Peptidase_M50; pfam02163
290397010032	active site
290397010033	putative substrate binding region [chemical binding]; other site
290397010034	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
290397010035	Glycoprotease family; Region: Peptidase_M22; pfam00814
290397010036	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290397010037	active site
290397010038	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290397010039	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290397010040	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
290397010041	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290397010042	putative substrate binding region [chemical binding]; other site
290397010043	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
290397010044	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
290397010045	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
290397010046	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
290397010047	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
290397010048	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
290397010049	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
290397010050	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
290397010051	catalytic residue [active]
290397010052	putative FPP diphosphate  binding site; other site
290397010053	putative FPP binding hydrophobic cleft; other site
290397010054	dimer interface [polypeptide binding]; other site
290397010055	putative IPP diphosphate binding site; other site
290397010056	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397010057	active site
290397010058	ATP binding site [chemical binding]; other site
290397010059	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
290397010060	ATP binding site [chemical binding]; other site
290397010061	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397010062	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290397010063	substrate binding site [chemical binding]; other site
290397010064	activation loop (A-loop); other site
290397010065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397010066	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397010067	Walker A motif; other site
290397010068	ATP binding site [chemical binding]; other site
290397010069	Walker B motif; other site
290397010070	aspartate kinase; Reviewed; Region: PRK06635
290397010071	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
290397010072	putative nucleotide binding site [chemical binding]; other site
290397010073	putative catalytic residues [active]
290397010074	putative Mg ion binding site [ion binding]; other site
290397010075	putative aspartate binding site [chemical binding]; other site
290397010076	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
290397010077	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
290397010078	oligomerisation interface [polypeptide binding]; other site
290397010079	mobile loop; other site
290397010080	roof hairpin; other site
290397010081	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
290397010082	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
290397010083	ring oligomerisation interface [polypeptide binding]; other site
290397010084	ATP/Mg binding site [chemical binding]; other site
290397010085	stacking interactions; other site
290397010086	hinge regions; other site
290397010087	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397010088	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397010089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397010090	TPR motif; other site
290397010091	binding surface
290397010092	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
290397010093	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
290397010094	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
290397010095	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
290397010096	Spore Coat Protein U domain; Region: SCPU; pfam05229
290397010097	Spore Coat Protein U domain; Region: SCPU; pfam05229
290397010098	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290397010099	active site
290397010100	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
290397010101	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
290397010102	amphipathic channel; other site
290397010103	Asn-Pro-Ala signature motifs; other site
290397010104	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
290397010105	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
290397010106	hypothetical protein; Provisional; Region: PRK08317
290397010107	Methyltransferase domain; Region: Methyltransf_11; pfam08241
290397010108	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
290397010109	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
290397010110	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
290397010111	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
290397010112	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
290397010113	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290397010114	minor groove reading motif; other site
290397010115	helix-hairpin-helix signature motif; other site
290397010116	substrate binding pocket [chemical binding]; other site
290397010117	active site
290397010118	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
290397010119	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
290397010120	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
290397010121	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
290397010122	tetramer interfaces [polypeptide binding]; other site
290397010123	binuclear metal-binding site [ion binding]; other site
290397010124	competence damage-inducible protein A; Provisional; Region: PRK00549
290397010125	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
290397010126	putative MPT binding site; other site
290397010127	Competence-damaged protein; Region: CinA; pfam02464
290397010128	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397010129	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
290397010130	Surface antigen; Region: Bac_surface_Ag; pfam01103
290397010131	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
290397010132	hexamer interface [polypeptide binding]; other site
290397010133	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397010134	Walker A motif; other site
290397010135	ATP binding site [chemical binding]; other site
290397010136	Walker B motif; other site
290397010137	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
290397010138	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
290397010139	catalytic residues [active]
290397010140	catalytic nucleophile [active]
290397010141	Beta protein; Region: Beta_protein; pfam14350
290397010142	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
290397010143	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290397010144	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
290397010145	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397010146	active site
290397010147	DNA methylase; Region: N6_N4_Mtase; cl17433
290397010148	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
290397010149	DNA methylase; Region: N6_N4_Mtase; pfam01555
290397010150	Restriction endonuclease; Region: Mrr_cat; pfam04471
290397010151	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290397010152	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
290397010153	Fe-S cluster binding site [ion binding]; other site
290397010154	DNA binding site [nucleotide binding]
290397010155	active site
290397010156	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
290397010157	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
290397010158	G1 box; other site
290397010159	GTP/Mg2+ binding site [chemical binding]; other site
290397010160	G2 box; other site
290397010161	Switch I region; other site
290397010162	G3 box; other site
290397010163	Switch II region; other site
290397010164	G4 box; other site
290397010165	G5 box; other site
290397010166	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
290397010167	recombination protein RecR; Reviewed; Region: recR; PRK00076
290397010168	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
290397010169	RecR protein; Region: RecR; pfam02132
290397010170	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
290397010171	putative active site [active]
290397010172	putative metal-binding site [ion binding]; other site
290397010173	tetramer interface [polypeptide binding]; other site
290397010174	hypothetical protein; Provisional; Region: PRK14622
290397010175	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
290397010176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397010177	Walker A motif; other site
290397010178	ATP binding site [chemical binding]; other site
290397010179	Walker B motif; other site
290397010180	arginine finger; other site
290397010181	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
290397010182	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
290397010183	nucleoside/Zn binding site; other site
290397010184	dimer interface [polypeptide binding]; other site
290397010185	catalytic motif [active]
290397010186	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
290397010187	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290397010188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397010189	FeS/SAM binding site; other site
290397010190	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397010191	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
290397010192	catalytic residues [active]
290397010193	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397010194	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
290397010195	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
290397010196	Permutation of conserved domain; other site
290397010197	active site
290397010198	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
290397010199	GAF domain; Region: GAF; pfam01590
290397010200	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290397010201	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397010202	ligand binding site [chemical binding]; other site
290397010203	Predicted membrane protein [Function unknown]; Region: COG2261
290397010204	TPR repeat; Region: TPR_11; pfam13414
290397010205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290397010206	binding surface
290397010207	TPR motif; other site
290397010208	PEGA domain; Region: PEGA; pfam08308
290397010209	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397010210	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397010211	active site
290397010212	ATP binding site [chemical binding]; other site
290397010213	substrate binding site [chemical binding]; other site
290397010214	activation loop (A-loop); other site
290397010215	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397010216	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397010217	phosphopeptide binding site; other site
290397010218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397010219	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290397010220	Walker A motif; other site
290397010221	ATP binding site [chemical binding]; other site
290397010222	Walker B motif; other site
290397010223	arginine finger; other site
290397010224	Helix-turn-helix domain; Region: HTH_17; pfam12728
290397010225	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
290397010226	active site
290397010227	phosphorylation site [posttranslational modification]
290397010228	hydrogenase 4 subunit B; Validated; Region: PRK06521
290397010229	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397010230	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397010231	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
290397010232	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
290397010233	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290397010234	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
290397010235	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
290397010236	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
290397010237	4Fe-4S binding domain; Region: Fer4; cl02805
290397010238	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290397010239	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
290397010240	PspC domain; Region: PspC; pfam04024
290397010241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397010242	S-adenosylmethionine binding site [chemical binding]; other site
290397010243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290397010244	Coenzyme A binding pocket [chemical binding]; other site
290397010245	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
290397010246	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
290397010247	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
290397010248	active site
290397010249	aconitate hydratase; Validated; Region: PRK09277
290397010250	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
290397010251	substrate binding site [chemical binding]; other site
290397010252	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
290397010253	ligand binding site [chemical binding]; other site
290397010254	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
290397010255	substrate binding site [chemical binding]; other site
290397010256	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
290397010257	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
290397010258	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290397010259	type I citrate synthase; Reviewed; Region: PRK09569
290397010260	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
290397010261	oxalacetate binding site [chemical binding]; other site
290397010262	citrylCoA binding site [chemical binding]; other site
290397010263	coenzyme A binding site [chemical binding]; other site
290397010264	catalytic triad [active]
290397010265	Peptidase family M23; Region: Peptidase_M23; pfam01551
290397010266	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
290397010267	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290397010268	RNA binding site [nucleotide binding]; other site
290397010269	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
290397010270	RNA binding site [nucleotide binding]; other site
290397010271	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
290397010272	RNA binding site [nucleotide binding]; other site
290397010273	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
290397010274	RNA binding site [nucleotide binding]; other site
290397010275	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
290397010276	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
290397010277	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
290397010278	catalytic site [active]
290397010279	active site
290397010280	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
290397010281	active site
290397010282	substrate-binding site [chemical binding]; other site
290397010283	metal-binding site [ion binding]
290397010284	GTP binding site [chemical binding]; other site
290397010285	NRDE protein; Region: NRDE; cl01315
290397010286	Protein of unknown function (DUF971); Region: DUF971; pfam06155
290397010287	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
290397010288	SmpB-tmRNA interface; other site
290397010289	Pantoate-beta-alanine ligase; Region: PanC; cd00560
290397010290	pantoate--beta-alanine ligase; Region: panC; TIGR00018
290397010291	active site
290397010292	ATP-binding site [chemical binding]; other site
290397010293	pantoate-binding site; other site
290397010294	HXXH motif; other site
290397010295	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
290397010296	oligomerization interface [polypeptide binding]; other site
290397010297	active site
290397010298	metal binding site [ion binding]; metal-binding site
290397010299	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
290397010300	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
290397010301	Substrate-binding site [chemical binding]; other site
290397010302	Substrate specificity [chemical binding]; other site
290397010303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397010304	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
290397010305	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
290397010306	UGMP family protein; Validated; Region: PRK09604
290397010307	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
290397010308	Response regulator receiver domain; Region: Response_reg; pfam00072
290397010309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010310	active site
290397010311	phosphorylation site [posttranslational modification]
290397010312	intermolecular recognition site; other site
290397010313	dimerization interface [polypeptide binding]; other site
290397010314	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397010315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397010316	TPR repeat; Region: TPR_11; pfam13414
290397010317	TPR motif; other site
290397010318	binding surface
290397010319	Tetratricopeptide repeat; Region: TPR_9; pfam13371
290397010320	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397010321	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397010322	HSP70 interaction site [polypeptide binding]; other site
290397010323	3-hydroxyisobutyryl-CoA hydrolase-like protein; Region: PLN02874
290397010324	Protein phosphatase 2C; Region: PP2C; pfam00481
290397010325	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
290397010326	active site
290397010327	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
290397010328	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
290397010329	Substrate binding site; other site
290397010330	metal-binding site
290397010331	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
290397010332	MFS_1 like family; Region: MFS_1_like; pfam12832
290397010333	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
290397010334	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290397010335	active site
290397010336	catalytic site [active]
290397010337	substrate binding site [chemical binding]; other site
290397010338	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
290397010339	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397010340	ligand binding site [chemical binding]; other site
290397010341	flexible hinge region; other site
290397010342	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
290397010343	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
290397010344	metal binding triad; other site
290397010345	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
290397010346	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
290397010347	Na binding site [ion binding]; other site
290397010348	putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647
290397010349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397010350	putative substrate translocation pore; other site
290397010351	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397010352	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397010353	active site
290397010354	ATP binding site [chemical binding]; other site
290397010355	substrate binding site [chemical binding]; other site
290397010356	activation loop (A-loop); other site
290397010357	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290397010358	Ligand Binding Site [chemical binding]; other site
290397010359	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
290397010360	active site
290397010361	metal binding site [ion binding]; metal-binding site
290397010362	Protein of unknown function, DUF485; Region: DUF485; pfam04341
290397010363	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
290397010364	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
290397010365	Na binding site [ion binding]; other site
290397010366	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
290397010367	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
290397010368	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397010369	dimer interface [polypeptide binding]; other site
290397010370	putative CheW interface [polypeptide binding]; other site
290397010371	Phosphotransferase enzyme family; Region: APH; pfam01636
290397010372	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
290397010373	active site
290397010374	ATP binding site [chemical binding]; other site
290397010375	substrate binding site [chemical binding]; other site
290397010376	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
290397010377	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290397010378	dimer interface [polypeptide binding]; other site
290397010379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397010380	catalytic residue [active]
290397010381	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
290397010382	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
290397010383	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290397010384	homodimer interface [polypeptide binding]; other site
290397010385	substrate-cofactor binding pocket; other site
290397010386	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397010387	catalytic residue [active]
290397010388	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
290397010389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397010390	putative substrate translocation pore; other site
290397010391	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290397010392	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
290397010393	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
290397010394	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
290397010395	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
290397010396	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
290397010397	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
290397010398	catalytic site [active]
290397010399	active site
290397010400	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
290397010401	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
290397010402	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397010403	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397010404	dimer interface [polypeptide binding]; other site
290397010405	putative CheW interface [polypeptide binding]; other site
290397010406	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
290397010407	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
290397010408	active site
290397010409	FMN binding site [chemical binding]; other site
290397010410	substrate binding site [chemical binding]; other site
290397010411	homotetramer interface [polypeptide binding]; other site
290397010412	catalytic residue [active]
290397010413	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
290397010414	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
290397010415	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
290397010416	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
290397010417	putative RNA binding site [nucleotide binding]; other site
290397010418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397010419	S-adenosylmethionine binding site [chemical binding]; other site
290397010420	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
290397010421	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290397010422	ligand binding site [chemical binding]; other site
290397010423	flexible hinge region; other site
290397010424	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
290397010425	active site
290397010426	PAS domain; Region: PAS_9; pfam13426
290397010427	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397010428	putative active site [active]
290397010429	heme pocket [chemical binding]; other site
290397010430	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290397010431	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290397010432	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
290397010433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397010434	ATP binding site [chemical binding]; other site
290397010435	Mg2+ binding site [ion binding]; other site
290397010436	G-X-G motif; other site
290397010437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397010438	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
290397010439	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290397010440	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
290397010441	motif 1; other site
290397010442	dimer interface [polypeptide binding]; other site
290397010443	active site
290397010444	motif 2; other site
290397010445	motif 3; other site
290397010446	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
290397010447	Zn binding site [ion binding]; other site
290397010448	PAS domain; Region: PAS_9; pfam13426
290397010449	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397010450	putative active site [active]
290397010451	heme pocket [chemical binding]; other site
290397010452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397010453	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290397010454	putative active site [active]
290397010455	heme pocket [chemical binding]; other site
290397010456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397010457	dimer interface [polypeptide binding]; other site
290397010458	phosphorylation site [posttranslational modification]
290397010459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397010460	ATP binding site [chemical binding]; other site
290397010461	Mg2+ binding site [ion binding]; other site
290397010462	G-X-G motif; other site
290397010463	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397010464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010465	active site
290397010466	phosphorylation site [posttranslational modification]
290397010467	intermolecular recognition site; other site
290397010468	dimerization interface [polypeptide binding]; other site
290397010469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397010470	Walker A motif; other site
290397010471	ATP binding site [chemical binding]; other site
290397010472	Walker B motif; other site
290397010473	arginine finger; other site
290397010474	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397010475	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
290397010476	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
290397010477	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
290397010478	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290397010479	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290397010480	TAP-like protein; Region: Abhydrolase_4; pfam08386
290397010481	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
290397010482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397010483	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290397010484	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397010485	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397010486	DNA binding residues [nucleotide binding]
290397010487	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
290397010488	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
290397010489	glycogen binding site [chemical binding]; other site
290397010490	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397010491	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397010492	active site
290397010493	ATP binding site [chemical binding]; other site
290397010494	substrate binding site [chemical binding]; other site
290397010495	activation loop (A-loop); other site
290397010496	PEGA domain; Region: PEGA; pfam08308
290397010497	PEGA domain; Region: PEGA; pfam08308
290397010498	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
290397010499	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
290397010500	phosphopeptide binding site; other site
290397010501	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
290397010502	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290397010503	substrate binding site [chemical binding]; other site
290397010504	oxyanion hole (OAH) forming residues; other site
290397010505	trimer interface [polypeptide binding]; other site
290397010506	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290397010507	carboxyltransferase (CT) interaction site; other site
290397010508	biotinylation site [posttranslational modification]; other site
290397010509	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
290397010510	CoenzymeA binding site [chemical binding]; other site
290397010511	subunit interaction site [polypeptide binding]; other site
290397010512	PHB binding site; other site
290397010513	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
290397010514	PilZ domain; Region: PilZ; cl01260
290397010515	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397010516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010517	active site
290397010518	phosphorylation site [posttranslational modification]
290397010519	intermolecular recognition site; other site
290397010520	dimerization interface [polypeptide binding]; other site
290397010521	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290397010522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397010523	NAD(P) binding site [chemical binding]; other site
290397010524	active site
290397010525	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
290397010526	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290397010527	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397010528	ligand binding site [chemical binding]; other site
290397010529	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290397010530	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
290397010531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397010532	catalytic residue [active]
290397010533	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
290397010534	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
290397010535	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
290397010536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397010537	putative PBP binding loops; other site
290397010538	dimer interface [polypeptide binding]; other site
290397010539	ABC-ATPase subunit interface; other site
290397010540	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
290397010541	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
290397010542	Walker A/P-loop; other site
290397010543	ATP binding site [chemical binding]; other site
290397010544	Q-loop/lid; other site
290397010545	ABC transporter signature motif; other site
290397010546	Walker B; other site
290397010547	D-loop; other site
290397010548	H-loop/switch region; other site
290397010549	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397010550	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397010551	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397010552	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290397010553	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
290397010554	molybdopterin cofactor binding site; other site
290397010555	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
290397010556	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290397010557	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
290397010558	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290397010559	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290397010560	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
290397010561	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
290397010562	short chain dehydrogenase; Provisional; Region: PRK08278
290397010563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397010564	NAD(P) binding site [chemical binding]; other site
290397010565	active site
290397010566	cell division protein MraZ; Reviewed; Region: PRK00326
290397010567	MraZ protein; Region: MraZ; pfam02381
290397010568	MraZ protein; Region: MraZ; pfam02381
290397010569	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
290397010570	MraW methylase family; Region: Methyltransf_5; cl17771
290397010571	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
290397010572	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
290397010573	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290397010574	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290397010575	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
290397010576	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
290397010577	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290397010578	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290397010579	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397010580	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
290397010581	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290397010582	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397010583	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
290397010584	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
290397010585	Mg++ binding site [ion binding]; other site
290397010586	putative catalytic motif [active]
290397010587	putative substrate binding site [chemical binding]; other site
290397010588	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
290397010589	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
290397010590	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290397010591	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397010592	cell division protein FtsW; Region: ftsW; TIGR02614
290397010593	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
290397010594	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
290397010595	active site
290397010596	homodimer interface [polypeptide binding]; other site
290397010597	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
290397010598	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290397010599	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290397010600	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290397010601	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652
290397010602	FAD binding domain; Region: FAD_binding_4; pfam01565
290397010603	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
290397010604	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
290397010605	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
290397010606	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290397010607	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397010608	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397010609	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397010610	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
290397010611	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
290397010612	Cell division protein FtsQ; Region: FtsQ; pfam03799
290397010613	cell division protein FtsA; Region: ftsA; TIGR01174
290397010614	Cell division protein FtsA; Region: FtsA; smart00842
290397010615	Cell division protein FtsA; Region: FtsA; pfam14450
290397010616	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
290397010617	cell division protein FtsZ; Validated; Region: PRK09330
290397010618	nucleotide binding site [chemical binding]; other site
290397010619	SulA interaction site; other site
290397010620	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290397010621	Zn2+ binding site [ion binding]; other site
290397010622	Mg2+ binding site [ion binding]; other site
290397010623	Putative esterase; Region: Esterase; pfam00756
290397010624	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
290397010625	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
290397010626	motif 1; other site
290397010627	active site
290397010628	motif 2; other site
290397010629	motif 3; other site
290397010630	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
290397010631	DHHA1 domain; Region: DHHA1; pfam02272
290397010632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397010633	S-adenosylmethionine binding site [chemical binding]; other site
290397010634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397010635	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397010636	Walker A/P-loop; other site
290397010637	ATP binding site [chemical binding]; other site
290397010638	Q-loop/lid; other site
290397010639	ABC transporter signature motif; other site
290397010640	Walker B; other site
290397010641	D-loop; other site
290397010642	H-loop/switch region; other site
290397010643	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290397010644	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290397010645	catalytic residue [active]
290397010646	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397010647	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290397010648	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
290397010649	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
290397010650	FMN binding site [chemical binding]; other site
290397010651	active site
290397010652	catalytic residues [active]
290397010653	substrate binding site [chemical binding]; other site
290397010654	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
290397010655	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
290397010656	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
290397010657	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290397010658	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
290397010659	DNA binding residues [nucleotide binding]
290397010660	dimerization interface [polypeptide binding]; other site
290397010661	putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900
290397010662	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290397010663	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290397010664	protein binding site [polypeptide binding]; other site
290397010665	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290397010666	Catalytic dyad [active]
290397010667	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
290397010668	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
290397010669	Ligand Binding Site [chemical binding]; other site
290397010670	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
290397010671	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
290397010672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397010673	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
290397010674	Phospholipid methyltransferase; Region: PEMT; cl17370
290397010675	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290397010676	metal binding site 2 [ion binding]; metal-binding site
290397010677	putative DNA binding helix; other site
290397010678	metal binding site 1 [ion binding]; metal-binding site
290397010679	dimer interface [polypeptide binding]; other site
290397010680	structural Zn2+ binding site [ion binding]; other site
290397010681	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
290397010682	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
290397010683	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
290397010684	dimer interface [polypeptide binding]; other site
290397010685	ssDNA binding site [nucleotide binding]; other site
290397010686	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290397010687	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
290397010688	TPR repeat; Region: TPR_11; pfam13414
290397010689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397010690	binding surface
290397010691	TPR motif; other site
290397010692	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290397010693	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
290397010694	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290397010695	motif II; other site
290397010696	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290397010697	putative DNA binding site [nucleotide binding]; other site
290397010698	putative Zn2+ binding site [ion binding]; other site
290397010699	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
290397010700	putative hydrophobic ligand binding site [chemical binding]; other site
290397010701	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
290397010702	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
290397010703	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
290397010704	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
290397010705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
290397010706	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
290397010707	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
290397010708	active site
290397010709	dimer interface [polypeptide binding]; other site
290397010710	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290397010711	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290397010712	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290397010713	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
290397010714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397010715	dimer interface [polypeptide binding]; other site
290397010716	conserved gate region; other site
290397010717	putative PBP binding loops; other site
290397010718	ABC-ATPase subunit interface; other site
290397010719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397010720	dimer interface [polypeptide binding]; other site
290397010721	conserved gate region; other site
290397010722	putative PBP binding loops; other site
290397010723	ABC-ATPase subunit interface; other site
290397010724	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
290397010725	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
290397010726	Walker A/P-loop; other site
290397010727	ATP binding site [chemical binding]; other site
290397010728	Q-loop/lid; other site
290397010729	ABC transporter signature motif; other site
290397010730	Walker B; other site
290397010731	D-loop; other site
290397010732	H-loop/switch region; other site
290397010733	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
290397010734	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
290397010735	hypothetical protein; Reviewed; Region: PRK00024
290397010736	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290397010737	MPN+ (JAMM) motif; other site
290397010738	Zinc-binding site [ion binding]; other site
290397010739	Peptidase family C69; Region: Peptidase_C69; cl17793
290397010740	Uncharacterized conserved protein [Function unknown]; Region: COG2353
290397010741	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
290397010742	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
290397010743	metal binding site [ion binding]; metal-binding site
290397010744	putative dimer interface [polypeptide binding]; other site
290397010745	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
290397010746	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
290397010747	trimer interface [polypeptide binding]; other site
290397010748	active site
290397010749	substrate binding site [chemical binding]; other site
290397010750	CoA binding site [chemical binding]; other site
290397010751	succinyldiaminopimelate transaminase; Region: DapC; TIGR03537
290397010752	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397010753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397010754	homodimer interface [polypeptide binding]; other site
290397010755	catalytic residue [active]
290397010756	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
290397010757	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
290397010758	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397010759	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290397010760	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
290397010761	glutathione s-transferase; Provisional; Region: PTZ00057
290397010762	GSH binding site (G-site) [chemical binding]; other site
290397010763	C-terminal domain interface [polypeptide binding]; other site
290397010764	dimer interface [polypeptide binding]; other site
290397010765	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
290397010766	dimer interface [polypeptide binding]; other site
290397010767	N-terminal domain interface [polypeptide binding]; other site
290397010768	substrate binding pocket (H-site) [chemical binding]; other site
290397010769	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290397010770	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397010771	P-loop; other site
290397010772	Magnesium ion binding site [ion binding]; other site
290397010773	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397010774	Magnesium ion binding site [ion binding]; other site
290397010775	HEAT repeats; Region: HEAT_2; pfam13646
290397010776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397010777	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397010778	putative substrate translocation pore; other site
290397010779	FOG: CBS domain [General function prediction only]; Region: COG0517
290397010780	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
290397010781	Transporter associated domain; Region: CorC_HlyC; smart01091
290397010782	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
290397010783	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
290397010784	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
290397010785	putative active site [active]
290397010786	catalytic triad [active]
290397010787	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290397010788	Response regulator receiver domain; Region: Response_reg; pfam00072
290397010789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010790	active site
290397010791	phosphorylation site [posttranslational modification]
290397010792	intermolecular recognition site; other site
290397010793	dimerization interface [polypeptide binding]; other site
290397010794	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
290397010795	protease TldD; Provisional; Region: tldD; PRK10735
290397010796	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
290397010797	TAP-like protein; Region: Abhydrolase_4; pfam08386
290397010798	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290397010799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397010800	NAD(P) binding site [chemical binding]; other site
290397010801	active site
290397010802	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290397010803	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397010804	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
290397010805	seryl-tRNA synthetase; Provisional; Region: PRK05431
290397010806	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
290397010807	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
290397010808	dimer interface [polypeptide binding]; other site
290397010809	active site
290397010810	motif 1; other site
290397010811	motif 2; other site
290397010812	motif 3; other site
290397010813	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
290397010814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397010815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397010816	dimer interface [polypeptide binding]; other site
290397010817	phosphorylation site [posttranslational modification]
290397010818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397010819	ATP binding site [chemical binding]; other site
290397010820	Mg2+ binding site [ion binding]; other site
290397010821	G-X-G motif; other site
290397010822	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290397010823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010824	active site
290397010825	phosphorylation site [posttranslational modification]
290397010826	intermolecular recognition site; other site
290397010827	dimerization interface [polypeptide binding]; other site
290397010828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397010829	DNA binding site [nucleotide binding]
290397010830	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
290397010831	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397010832	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397010833	Outer membrane efflux protein; Region: OEP; pfam02321
290397010834	TIGR02680 family protein; Region: TIGR02680
290397010835	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
290397010836	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
290397010837	TIGR02677 family protein; Region: TIGR02677
290397010838	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
290397010839	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
290397010840	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
290397010841	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
290397010842	catalytic site [active]
290397010843	HNH endonuclease; Region: HNH_2; pfam13391
290397010844	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
290397010845	PLD-like domain; Region: PLDc_2; pfam13091
290397010846	putative homodimer interface [polypeptide binding]; other site
290397010847	putative active site [active]
290397010848	catalytic site [active]
290397010849	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
290397010850	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397010851	ATP binding site [chemical binding]; other site
290397010852	putative Mg++ binding site [ion binding]; other site
290397010853	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397010854	nucleotide binding region [chemical binding]; other site
290397010855	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
290397010856	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
290397010857	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
290397010858	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
290397010859	SnoaL-like domain; Region: SnoaL_2; pfam12680
290397010860	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397010861	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397010862	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
290397010863	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
290397010864	Family description; Region: UvrD_C_2; pfam13538
290397010865	SEC-C motif; Region: SEC-C; pfam02810
290397010866	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
290397010867	HD domain; Region: HD_4; pfam13328
290397010868	B12 binding domain; Region: B12-binding; pfam02310
290397010869	B12 binding site [chemical binding]; other site
290397010870	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290397010871	CHASE2 domain; Region: CHASE2; pfam05226
290397010872	hypothetical protein; Provisional; Region: PRK07546
290397010873	substrate-cofactor binding pocket; other site
290397010874	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
290397010875	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
290397010876	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
290397010877	glycoprotein BALF4; Provisional; Region: PHA03231
290397010878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397010879	phosphorylation site [posttranslational modification]
290397010880	intermolecular recognition site; other site
290397010881	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
290397010882	active site
290397010883	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
290397010884	Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598
290397010885	Zn binding site [ion binding]; other site
290397010886	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290397010887	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
290397010888	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397010889	dimerization interface [polypeptide binding]; other site
290397010890	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397010891	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397010892	dimer interface [polypeptide binding]; other site
290397010893	putative CheW interface [polypeptide binding]; other site
290397010894	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
290397010895	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
290397010896	active site
290397010897	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
290397010898	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
290397010899	active site
290397010900	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
290397010901	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
290397010902	putative NADP binding site [chemical binding]; other site
290397010903	active site
290397010904	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
290397010905	active site
290397010906	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
290397010907	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
290397010908	active site
290397010909	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
290397010910	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
290397010911	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
290397010912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397010913	HTH domain; Region: HTH_11; pfam08279
290397010914	WYL domain; Region: WYL; pfam13280
290397010915	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cd00480
290397010916	active site
290397010917	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290397010918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397010919	S-adenosylmethionine binding site [chemical binding]; other site
290397010920	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
290397010921	putative catalytic residues [active]
290397010922	Acetokinase family; Region: Acetate_kinase; cl17229
290397010923	propionate/acetate kinase; Provisional; Region: PRK12379
290397010924	Uncharacterized conserved protein [Function unknown]; Region: COG3791
290397010925	RibD C-terminal domain; Region: RibD_C; cl17279
290397010926	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
290397010927	RibD C-terminal domain; Region: RibD_C; cl17279
290397010928	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397010929	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
290397010930	Walker A/P-loop; other site
290397010931	ATP binding site [chemical binding]; other site
290397010932	Q-loop/lid; other site
290397010933	ABC transporter signature motif; other site
290397010934	Walker B; other site
290397010935	D-loop; other site
290397010936	H-loop/switch region; other site
290397010937	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
290397010938	ABC-2 type transporter; Region: ABC2_membrane; cl17235
290397010939	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
290397010940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397010941	Walker A/P-loop; other site
290397010942	ATP binding site [chemical binding]; other site
290397010943	Q-loop/lid; other site
290397010944	ABC transporter signature motif; other site
290397010945	Walker B; other site
290397010946	D-loop; other site
290397010947	H-loop/switch region; other site
290397010948	ABC transporter; Region: ABC_tran_2; pfam12848
290397010949	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397010950	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
290397010951	putative dimer interface [polypeptide binding]; other site
290397010952	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397010953	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
290397010954	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
290397010955	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
290397010956	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
290397010957	benzoate transport; Region: 2A0115; TIGR00895
290397010958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397010959	putative substrate translocation pore; other site
290397010960	RmuC family; Region: RmuC; pfam02646
290397010961	WYL domain; Region: WYL; pfam13280
290397010962	WYL domain; Region: WYL; pfam13280
290397010963	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
290397010964	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290397010965	putative acyl-acceptor binding pocket; other site
290397010966	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
290397010967	Amidase; Region: Amidase; pfam01425
290397010968	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
290397010969	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
290397010970	putative DNA binding site [nucleotide binding]; other site
290397010971	catalytic residue [active]
290397010972	putative H2TH interface [polypeptide binding]; other site
290397010973	putative catalytic residues [active]
290397010974	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
290397010975	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
290397010976	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
290397010977	Malic enzyme, N-terminal domain; Region: malic; pfam00390
290397010978	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
290397010979	putative NAD(P) binding site [chemical binding]; other site
290397010980	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
290397010981	homoserine dehydrogenase; Provisional; Region: PRK06270
290397010982	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
290397010983	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
290397010984	Domain of unknown function DUF302; Region: DUF302; pfam03625
290397010985	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290397010986	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397010987	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397010988	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397010989	active site
290397010990	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290397010991	FtsX-like permease family; Region: FtsX; pfam02687
290397010992	FtsX-like permease family; Region: FtsX; pfam02687
290397010993	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397010994	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397010995	Walker A/P-loop; other site
290397010996	ATP binding site [chemical binding]; other site
290397010997	Q-loop/lid; other site
290397010998	ABC transporter signature motif; other site
290397010999	Walker B; other site
290397011000	D-loop; other site
290397011001	H-loop/switch region; other site
290397011002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
290397011003	Smr domain; Region: Smr; pfam01713
290397011004	Outer membrane efflux protein; Region: OEP; pfam02321
290397011005	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397011006	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397011007	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290397011008	Protein export membrane protein; Region: SecD_SecF; cl14618
290397011009	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
290397011010	MgtE intracellular N domain; Region: MgtE_N; smart00924
290397011011	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
290397011012	Divalent cation transporter; Region: MgtE; pfam01769
290397011013	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
290397011014	active site
290397011015	dimer interface [polypeptide binding]; other site
290397011016	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397011017	prolyl-tRNA synthetase; Provisional; Region: PRK09194
290397011018	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
290397011019	dimer interface [polypeptide binding]; other site
290397011020	motif 1; other site
290397011021	active site
290397011022	motif 2; other site
290397011023	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
290397011024	putative deacylase active site [active]
290397011025	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290397011026	active site
290397011027	motif 3; other site
290397011028	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
290397011029	anticodon binding site; other site
290397011030	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290397011031	GcpE protein; Region: GcpE; pfam04551
290397011032	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290397011033	Thioredoxin; Region: Thioredoxin_4; pfam13462
290397011034	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397011035	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
290397011036	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290397011037	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290397011038	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
290397011039	trimer interface [polypeptide binding]; other site
290397011040	dimer interface [polypeptide binding]; other site
290397011041	putative active site [active]
290397011042	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290397011043	CheW-like domain; Region: CheW; pfam01584
290397011044	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
290397011045	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
290397011046	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
290397011047	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
290397011048	Substrate binding site; other site
290397011049	Mg++ binding site; other site
290397011050	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
290397011051	active site
290397011052	substrate binding site [chemical binding]; other site
290397011053	CoA binding site [chemical binding]; other site
290397011054	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
290397011055	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
290397011056	glutaminase active site [active]
290397011057	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
290397011058	dimer interface [polypeptide binding]; other site
290397011059	active site
290397011060	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
290397011061	dimer interface [polypeptide binding]; other site
290397011062	active site
290397011063	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
290397011064	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
290397011065	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
290397011066	Protein of unknown function (DUF2378); Region: DUF2378; pfam09536
290397011067	recombinase A; Provisional; Region: recA; PRK09354
290397011068	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
290397011069	hexamer interface [polypeptide binding]; other site
290397011070	Walker A motif; other site
290397011071	ATP binding site [chemical binding]; other site
290397011072	Walker B motif; other site
290397011073	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
290397011074	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
290397011075	MOFRL family; Region: MOFRL; pfam05161
290397011076	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
290397011077	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
290397011078	putative active site [active]
290397011079	substrate binding site [chemical binding]; other site
290397011080	putative cosubstrate binding site; other site
290397011081	catalytic site [active]
290397011082	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
290397011083	substrate binding site [chemical binding]; other site
290397011084	16S rRNA methyltransferase B; Provisional; Region: PRK14902
290397011085	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
290397011086	putative RNA binding site [nucleotide binding]; other site
290397011087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397011088	S-adenosylmethionine binding site [chemical binding]; other site
290397011089	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
290397011090	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
290397011091	substrate binding site [chemical binding]; other site
290397011092	hexamer interface [polypeptide binding]; other site
290397011093	metal binding site [ion binding]; metal-binding site
290397011094	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
290397011095	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
290397011096	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
290397011097	ligand binding site [chemical binding]; other site
290397011098	active site
290397011099	Response regulator receiver domain; Region: Response_reg; pfam00072
290397011100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011101	active site
290397011102	phosphorylation site [posttranslational modification]
290397011103	intermolecular recognition site; other site
290397011104	dimerization interface [polypeptide binding]; other site
290397011105	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
290397011106	TMAO/DMSO reductase; Reviewed; Region: PRK05363
290397011107	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
290397011108	Moco binding site; other site
290397011109	metal coordination site [ion binding]; other site
290397011110	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
290397011111	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
290397011112	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
290397011113	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
290397011114	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
290397011115	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
290397011116	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
290397011117	Methyltransferase domain; Region: Methyltransf_32; pfam13679
290397011118	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
290397011119	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
290397011120	putative active site [active]
290397011121	catalytic site [active]
290397011122	putative metal binding site [ion binding]; other site
290397011123	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397011124	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397011125	active site
290397011126	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
290397011127	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397011128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290397011129	Walker A/P-loop; other site
290397011130	ATP binding site [chemical binding]; other site
290397011131	Q-loop/lid; other site
290397011132	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397011133	ABC transporter signature motif; other site
290397011134	Walker B; other site
290397011135	D-loop; other site
290397011136	ABC transporter; Region: ABC_tran_2; pfam12848
290397011137	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290397011138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397011139	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397011140	putative substrate translocation pore; other site
290397011141	Transposase IS200 like; Region: Y1_Tnp; cl00848
290397011142	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
290397011143	putative metal binding site; other site
290397011144	PEGA domain; Region: PEGA; pfam08308
290397011145	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
290397011146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397011147	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
290397011148	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397011149	Walker A/P-loop; other site
290397011150	ATP binding site [chemical binding]; other site
290397011151	Q-loop/lid; other site
290397011152	ABC transporter signature motif; other site
290397011153	Walker B; other site
290397011154	D-loop; other site
290397011155	H-loop/switch region; other site
290397011156	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
290397011157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397011158	dimer interface [polypeptide binding]; other site
290397011159	conserved gate region; other site
290397011160	putative PBP binding loops; other site
290397011161	ABC-ATPase subunit interface; other site
290397011162	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
290397011163	NlpC/P60 family; Region: NLPC_P60; cl17555
290397011164	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
290397011165	active site
290397011166	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
290397011167	PhoU domain; Region: PhoU; pfam01895
290397011168	PhoU domain; Region: PhoU; pfam01895
290397011169	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
290397011170	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
290397011171	Walker A/P-loop; other site
290397011172	ATP binding site [chemical binding]; other site
290397011173	Q-loop/lid; other site
290397011174	ABC transporter signature motif; other site
290397011175	Walker B; other site
290397011176	D-loop; other site
290397011177	H-loop/switch region; other site
290397011178	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
290397011179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397011180	dimer interface [polypeptide binding]; other site
290397011181	conserved gate region; other site
290397011182	putative PBP binding loops; other site
290397011183	ABC-ATPase subunit interface; other site
290397011184	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
290397011185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397011186	dimer interface [polypeptide binding]; other site
290397011187	conserved gate region; other site
290397011188	putative PBP binding loops; other site
290397011189	ABC-ATPase subunit interface; other site
290397011190	PBP superfamily domain; Region: PBP_like_2; cl17296
290397011191	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290397011192	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
290397011193	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290397011194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011195	dimer interface [polypeptide binding]; other site
290397011196	phosphorylation site [posttranslational modification]
290397011197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011198	ATP binding site [chemical binding]; other site
290397011199	Mg2+ binding site [ion binding]; other site
290397011200	G-X-G motif; other site
290397011201	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
290397011202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011203	active site
290397011204	phosphorylation site [posttranslational modification]
290397011205	intermolecular recognition site; other site
290397011206	dimerization interface [polypeptide binding]; other site
290397011207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290397011208	DNA binding site [nucleotide binding]
290397011209	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
290397011210	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290397011211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290397011212	metal binding site [ion binding]; metal-binding site
290397011213	active site
290397011214	I-site; other site
290397011215	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
290397011216	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
290397011217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290397011218	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397011219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397011220	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397011221	putative substrate translocation pore; other site
290397011222	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397011223	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397011224	active site
290397011225	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
290397011226	CoenzymeA binding site [chemical binding]; other site
290397011227	subunit interaction site [polypeptide binding]; other site
290397011228	PHB binding site; other site
290397011229	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
290397011230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397011231	POT family; Region: PTR2; cl17359
290397011232	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397011233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397011234	putative substrate translocation pore; other site
290397011235	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290397011236	active site residue [active]
290397011237	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
290397011238	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
290397011239	aromatic arch; other site
290397011240	DCoH dimer interaction site [polypeptide binding]; other site
290397011241	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
290397011242	DCoH tetramer interaction site [polypeptide binding]; other site
290397011243	substrate binding site [chemical binding]; other site
290397011244	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
290397011245	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290397011246	putative active site [active]
290397011247	putative metal binding site [ion binding]; other site
290397011248	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
290397011249	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397011250	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290397011251	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
290397011252	putative active site pocket [active]
290397011253	dimerization interface [polypeptide binding]; other site
290397011254	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
290397011255	putative catalytic residue [active]
290397011256	NAD-dependent deacetylase; Provisional; Region: PRK00481
290397011257	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
290397011258	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
290397011259	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
290397011260	intersubunit interface [polypeptide binding]; other site
290397011261	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
290397011262	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
290397011263	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
290397011264	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290397011265	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290397011266	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
290397011267	active site
290397011268	catalytic site [active]
290397011269	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
290397011270	active site
290397011271	catalytic site [active]
290397011272	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
290397011273	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290397011274	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290397011275	catalytic residues [active]
290397011276	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397011277	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397011278	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397011279	active site
290397011280	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290397011281	pyruvate phosphate dikinase; Provisional; Region: PRK09279
290397011282	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
290397011283	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290397011284	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290397011285	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
290397011286	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
290397011287	Ligand Binding Site [chemical binding]; other site
290397011288	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
290397011289	CPxP  motif; other site
290397011290	Thioredoxin; Region: Thioredoxin_4; pfam13462
290397011291	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397011292	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
290397011293	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397011294	Thioredoxin; Region: Thioredoxin_4; pfam13462
290397011295	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
290397011296	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
290397011297	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
290397011298	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
290397011299	tetramerization interface [polypeptide binding]; other site
290397011300	active site
290397011301	anthranilate synthase component I; Provisional; Region: PRK13565
290397011302	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
290397011303	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
290397011304	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
290397011305	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
290397011306	glutamine binding [chemical binding]; other site
290397011307	catalytic triad [active]
290397011308	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
290397011309	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
290397011310	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
290397011311	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
290397011312	active site
290397011313	ribulose/triose binding site [chemical binding]; other site
290397011314	phosphate binding site [ion binding]; other site
290397011315	substrate (anthranilate) binding pocket [chemical binding]; other site
290397011316	product (indole) binding pocket [chemical binding]; other site
290397011317	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
290397011318	active site
290397011319	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
290397011320	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290397011321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397011322	catalytic residue [active]
290397011323	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
290397011324	substrate binding site [chemical binding]; other site
290397011325	active site
290397011326	catalytic residues [active]
290397011327	heterodimer interface [polypeptide binding]; other site
290397011328	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
290397011329	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
290397011330	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290397011331	PGAP1-like protein; Region: PGAP1; pfam07819
290397011332	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
290397011333	active site
290397011334	intersubunit interactions; other site
290397011335	catalytic residue [active]
290397011336	KpsF/GutQ family protein; Region: kpsF; TIGR00393
290397011337	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
290397011338	putative active site [active]
290397011339	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
290397011340	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
290397011341	active site
290397011342	intersubunit interface [polypeptide binding]; other site
290397011343	Zn2+ binding site [ion binding]; other site
290397011344	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
290397011345	catalytic center binding site [active]
290397011346	ATP binding site [chemical binding]; other site
290397011347	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
290397011348	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
290397011349	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
290397011350	dihydrodipicolinate reductase; Provisional; Region: PRK00048
290397011351	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
290397011352	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
290397011353	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
290397011354	dimer interface [polypeptide binding]; other site
290397011355	active site
290397011356	catalytic residue [active]
290397011357	diaminopimelate decarboxylase; Region: lysA; TIGR01048
290397011358	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
290397011359	active site
290397011360	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290397011361	substrate binding site [chemical binding]; other site
290397011362	catalytic residues [active]
290397011363	dimer interface [polypeptide binding]; other site
290397011364	argininosuccinate lyase; Provisional; Region: PRK00855
290397011365	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
290397011366	active sites [active]
290397011367	tetramer interface [polypeptide binding]; other site
290397011368	OsmC-like protein; Region: OsmC; pfam02566
290397011369	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290397011370	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
290397011371	dimer interface [polypeptide binding]; other site
290397011372	substrate binding site [chemical binding]; other site
290397011373	metal binding site [ion binding]; metal-binding site
290397011374	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
290397011375	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
290397011376	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
290397011377	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
290397011378	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
290397011379	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290397011380	active site
290397011381	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290397011382	active site
290397011383	DNA methylase; Region: N6_N4_Mtase; cl17433
290397011384	Protein of unknown function (DUF938); Region: DUF938; pfam06080
290397011385	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397011386	HSP70 interaction site [polypeptide binding]; other site
290397011387	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
290397011388	Ferredoxin [Energy production and conversion]; Region: COG1146
290397011389	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
290397011390	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
290397011391	NAD(P) binding site [chemical binding]; other site
290397011392	Rib/alpha-like repeat; Region: Rib; cl07159
290397011393	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
290397011394	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397011395	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397011396	OPT oligopeptide transporter protein; Region: OPT; pfam03169
290397011397	oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728
290397011398	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
290397011399	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397011400	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290397011401	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
290397011402	Catalytic domain of Protein Kinases; Region: PKc; cd00180
290397011403	active site
290397011404	ATP binding site [chemical binding]; other site
290397011405	substrate binding site [chemical binding]; other site
290397011406	activation loop (A-loop); other site
290397011407	multifunctional aminopeptidase A; Provisional; Region: PRK00913
290397011408	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
290397011409	interface (dimer of trimers) [polypeptide binding]; other site
290397011410	Substrate-binding/catalytic site; other site
290397011411	Zn-binding sites [ion binding]; other site
290397011412	Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719
290397011413	dimer interface [polypeptide binding]; other site
290397011414	substrate binding site [chemical binding]; other site
290397011415	metal binding sites [ion binding]; metal-binding site
290397011416	Hemerythrin; Region: Hemerythrin; cd12107
290397011417	Fe binding site [ion binding]; other site
290397011418	Arginase family; Region: Arginase; pfam00491
290397011419	active site
290397011420	metal binding site [ion binding]; metal-binding site
290397011421	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290397011422	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
290397011423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397011424	homodimer interface [polypeptide binding]; other site
290397011425	catalytic residue [active]
290397011426	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
290397011427	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
290397011428	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397011429	Outer membrane efflux protein; Region: OEP; pfam02321
290397011430	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
290397011431	MarR family; Region: MarR; pfam01047
290397011432	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290397011433	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290397011434	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
290397011435	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
290397011436	putative active site [active]
290397011437	putative CoA binding site [chemical binding]; other site
290397011438	nudix motif; other site
290397011439	metal binding site [ion binding]; metal-binding site
290397011440	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
290397011441	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
290397011442	active site
290397011443	active site
290397011444	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
290397011445	Sel1-like repeats; Region: SEL1; smart00671
290397011446	Sel1-like repeats; Region: SEL1; smart00671
290397011447	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
290397011448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011449	phosphorylation site [posttranslational modification]
290397011450	intermolecular recognition site; other site
290397011451	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
290397011452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
290397011453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
290397011454	active site
290397011455	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290397011456	lipoyl attachment site [posttranslational modification]; other site
290397011457	Response regulator receiver domain; Region: Response_reg; pfam00072
290397011458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011459	active site
290397011460	phosphorylation site [posttranslational modification]
290397011461	intermolecular recognition site; other site
290397011462	dimerization interface [polypeptide binding]; other site
290397011463	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290397011464	PAS domain; Region: PAS_9; pfam13426
290397011465	putative active site [active]
290397011466	heme pocket [chemical binding]; other site
290397011467	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397011468	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011469	dimer interface [polypeptide binding]; other site
290397011470	phosphorylation site [posttranslational modification]
290397011471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011472	ATP binding site [chemical binding]; other site
290397011473	Mg2+ binding site [ion binding]; other site
290397011474	G-X-G motif; other site
290397011475	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
290397011476	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397011477	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011478	dimerization interface [polypeptide binding]; other site
290397011479	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011480	dimerization interface [polypeptide binding]; other site
290397011481	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011482	dimerization interface [polypeptide binding]; other site
290397011483	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011484	dimerization interface [polypeptide binding]; other site
290397011485	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397011486	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011487	dimerization interface [polypeptide binding]; other site
290397011488	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011489	dimerization interface [polypeptide binding]; other site
290397011490	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
290397011491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011492	dimerization interface [polypeptide binding]; other site
290397011493	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011494	dimerization interface [polypeptide binding]; other site
290397011495	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011496	dimerization interface [polypeptide binding]; other site
290397011497	HAMP domain; Region: HAMP; pfam00672
290397011498	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011499	dimerization interface [polypeptide binding]; other site
290397011500	GAF domain; Region: GAF_2; pfam13185
290397011501	GAF domain; Region: GAF_3; pfam13492
290397011502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011503	dimer interface [polypeptide binding]; other site
290397011504	phosphorylation site [posttranslational modification]
290397011505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011506	ATP binding site [chemical binding]; other site
290397011507	Mg2+ binding site [ion binding]; other site
290397011508	G-X-G motif; other site
290397011509	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397011510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011511	active site
290397011512	phosphorylation site [posttranslational modification]
290397011513	intermolecular recognition site; other site
290397011514	dimerization interface [polypeptide binding]; other site
290397011515	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
290397011516	trehalose synthase; Region: treS_nterm; TIGR02456
290397011517	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
290397011518	Ca binding site [ion binding]; other site
290397011519	active site
290397011520	catalytic site [active]
290397011521	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397011522	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397011523	active site
290397011524	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
290397011525	carbohydrate binding site [chemical binding]; other site
290397011526	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
290397011527	trimer interface; other site
290397011528	sugar binding site [chemical binding]; other site
290397011529	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
290397011530	putative ligand binding site [chemical binding]; other site
290397011531	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
290397011532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397011533	dimer interface [polypeptide binding]; other site
290397011534	conserved gate region; other site
290397011535	putative PBP binding loops; other site
290397011536	ABC-ATPase subunit interface; other site
290397011537	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
290397011538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290397011539	dimer interface [polypeptide binding]; other site
290397011540	conserved gate region; other site
290397011541	putative PBP binding loops; other site
290397011542	ABC-ATPase subunit interface; other site
290397011543	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
290397011544	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
290397011545	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
290397011546	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
290397011547	Walker A/P-loop; other site
290397011548	ATP binding site [chemical binding]; other site
290397011549	Q-loop/lid; other site
290397011550	ABC transporter signature motif; other site
290397011551	Walker B; other site
290397011552	D-loop; other site
290397011553	H-loop/switch region; other site
290397011554	TOBE domain; Region: TOBE_2; pfam08402
290397011555	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
290397011556	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290397011557	active site
290397011558	catalytic site [active]
290397011559	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
290397011560	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
290397011561	Uncharacterized conserved protein [Function unknown]; Region: COG3461
290397011562	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290397011563	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
290397011564	Response regulator receiver domain; Region: Response_reg; pfam00072
290397011565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011566	active site
290397011567	phosphorylation site [posttranslational modification]
290397011568	intermolecular recognition site; other site
290397011569	dimerization interface [polypeptide binding]; other site
290397011570	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
290397011571	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290397011572	active site
290397011573	metal binding site [ion binding]; metal-binding site
290397011574	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
290397011575	putative acyl-acceptor binding pocket; other site
290397011576	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290397011577	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
290397011578	putative acyl-acceptor binding pocket; other site
290397011579	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290397011580	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
290397011581	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
290397011582	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
290397011583	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
290397011584	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
290397011585	DoxX; Region: DoxX; pfam07681
290397011586	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
290397011587	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290397011588	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290397011589	HlyD family secretion protein; Region: HlyD_3; pfam13437
290397011590	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290397011591	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290397011592	Walker A/P-loop; other site
290397011593	ATP binding site [chemical binding]; other site
290397011594	Q-loop/lid; other site
290397011595	ABC transporter signature motif; other site
290397011596	Walker B; other site
290397011597	D-loop; other site
290397011598	H-loop/switch region; other site
290397011599	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397011600	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290397011601	FtsX-like permease family; Region: FtsX; pfam02687
290397011602	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290397011603	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290397011604	FtsX-like permease family; Region: FtsX; pfam02687
290397011605	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
290397011606	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290397011607	Catalytic site [active]
290397011608	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290397011609	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290397011610	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290397011611	active site
290397011612	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
290397011613	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
290397011614	active site
290397011615	DNA binding site [nucleotide binding]
290397011616	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
290397011617	DNA binding site [nucleotide binding]
290397011618	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
290397011619	nickel binding site [ion binding]; other site
290397011620	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
290397011621	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
290397011622	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
290397011623	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290397011624	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
290397011625	4Fe-4S binding domain; Region: Fer4; pfam00037
290397011626	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
290397011627	active site
290397011628	phosphorylation site [posttranslational modification]
290397011629	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
290397011630	30S subunit binding site; other site
290397011631	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
290397011632	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
290397011633	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
290397011634	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
290397011635	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
290397011636	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
290397011637	Walker A/P-loop; other site
290397011638	ATP binding site [chemical binding]; other site
290397011639	Q-loop/lid; other site
290397011640	ABC transporter signature motif; other site
290397011641	Walker B; other site
290397011642	D-loop; other site
290397011643	H-loop/switch region; other site
290397011644	OstA-like protein; Region: OstA; cl00844
290397011645	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
290397011646	putative acyl-acceptor binding pocket; other site
290397011647	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290397011648	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
290397011649	CTP synthetase; Validated; Region: pyrG; PRK05380
290397011650	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
290397011651	Catalytic site [active]
290397011652	active site
290397011653	UTP binding site [chemical binding]; other site
290397011654	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
290397011655	active site
290397011656	putative oxyanion hole; other site
290397011657	catalytic triad [active]
290397011658	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
290397011659	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
290397011660	Ligand binding site; other site
290397011661	oligomer interface; other site
290397011662	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290397011663	active site
290397011664	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
290397011665	homodimer interface [polypeptide binding]; other site
290397011666	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290397011667	S4 RNA-binding domain; Region: S4; smart00363
290397011668	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290397011669	active site
290397011670	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290397011671	GTPase CgtA; Reviewed; Region: obgE; PRK12299
290397011672	GTP1/OBG; Region: GTP1_OBG; pfam01018
290397011673	Obg GTPase; Region: Obg; cd01898
290397011674	G1 box; other site
290397011675	GTP/Mg2+ binding site [chemical binding]; other site
290397011676	Switch I region; other site
290397011677	G2 box; other site
290397011678	G3 box; other site
290397011679	Switch II region; other site
290397011680	G4 box; other site
290397011681	G5 box; other site
290397011682	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
290397011683	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
290397011684	Uncharacterized conserved protein [Function unknown]; Region: COG3339
290397011685	Inward rectifier potassium channel; Region: IRK; pfam01007
290397011686	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
290397011687	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
290397011688	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
290397011689	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
290397011690	GatB domain; Region: GatB_Yqey; smart00845
290397011691	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
290397011692	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
290397011693	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
290397011694	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
290397011695	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
290397011696	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397011697	binding surface
290397011698	TPR motif; other site
290397011699	TPR repeat; Region: TPR_11; pfam13414
290397011700	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
290397011701	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
290397011702	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
290397011703	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
290397011704	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
290397011705	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
290397011706	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290397011707	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290397011708	ligand binding site [chemical binding]; other site
290397011709	membrane protein; Provisional; Region: PRK14400
290397011710	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
290397011711	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
290397011712	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
290397011713	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
290397011714	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
290397011715	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
290397011716	SLBB domain; Region: SLBB; pfam10531
290397011717	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
290397011718	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
290397011719	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
290397011720	putative dimer interface [polypeptide binding]; other site
290397011721	[2Fe-2S] cluster binding site [ion binding]; other site
290397011722	PilZ domain; Region: PilZ; cl01260
290397011723	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397011724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011725	active site
290397011726	phosphorylation site [posttranslational modification]
290397011727	intermolecular recognition site; other site
290397011728	dimerization interface [polypeptide binding]; other site
290397011729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
290397011730	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290397011731	IHF - DNA interface [nucleotide binding]; other site
290397011732	IHF dimer interface [polypeptide binding]; other site
290397011733	PilZ domain; Region: PilZ; pfam07238
290397011734	amidophosphoribosyltransferase; Provisional; Region: PRK09123
290397011735	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
290397011736	active site
290397011737	tetramer interface [polypeptide binding]; other site
290397011738	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290397011739	active site
290397011740	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
290397011741	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290397011742	active site
290397011743	PEGA domain; Region: PEGA; pfam08308
290397011744	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
290397011745	PilZ domain; Region: PilZ; cl01260
290397011746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011747	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397011748	active site
290397011749	phosphorylation site [posttranslational modification]
290397011750	intermolecular recognition site; other site
290397011751	dimerization interface [polypeptide binding]; other site
290397011752	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
290397011753	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
290397011754	dimerization interface [polypeptide binding]; other site
290397011755	ATP binding site [chemical binding]; other site
290397011756	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
290397011757	dimerization interface [polypeptide binding]; other site
290397011758	ATP binding site [chemical binding]; other site
290397011759	RNase_H superfamily; Region: RNase_H_2; pfam13482
290397011760	Part of AAA domain; Region: AAA_19; pfam13245
290397011761	AAA domain; Region: AAA_12; pfam13087
290397011762	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011763	dimer interface [polypeptide binding]; other site
290397011764	phosphorylation site [posttranslational modification]
290397011765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011766	ATP binding site [chemical binding]; other site
290397011767	Mg2+ binding site [ion binding]; other site
290397011768	G-X-G motif; other site
290397011769	Response regulator receiver domain; Region: Response_reg; pfam00072
290397011770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011771	active site
290397011772	phosphorylation site [posttranslational modification]
290397011773	intermolecular recognition site; other site
290397011774	dimerization interface [polypeptide binding]; other site
290397011775	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
290397011776	active site
290397011777	Smr domain; Region: Smr; pfam01713
290397011778	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
290397011779	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
290397011780	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
290397011781	30S subunit binding site; other site
290397011782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011783	active site
290397011784	phosphorylation site [posttranslational modification]
290397011785	intermolecular recognition site; other site
290397011786	dimerization interface [polypeptide binding]; other site
290397011787	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
290397011788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011789	dimer interface [polypeptide binding]; other site
290397011790	phosphorylation site [posttranslational modification]
290397011791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011792	ATP binding site [chemical binding]; other site
290397011793	G-X-G motif; other site
290397011794	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397011795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011796	active site
290397011797	phosphorylation site [posttranslational modification]
290397011798	intermolecular recognition site; other site
290397011799	dimerization interface [polypeptide binding]; other site
290397011800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011801	ATP binding site [chemical binding]; other site
290397011802	Mg2+ binding site [ion binding]; other site
290397011803	G-X-G motif; other site
290397011804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011805	dimerization interface [polypeptide binding]; other site
290397011806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011807	phosphorylation site [posttranslational modification]
290397011808	dimer interface [polypeptide binding]; other site
290397011809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011810	ATP binding site [chemical binding]; other site
290397011811	Mg2+ binding site [ion binding]; other site
290397011812	G-X-G motif; other site
290397011813	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
290397011814	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
290397011815	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
290397011816	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290397011817	FeS/SAM binding site; other site
290397011818	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
290397011819	active site
290397011820	DNA binding site [nucleotide binding]
290397011821	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
290397011822	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
290397011823	domain interfaces; other site
290397011824	active site
290397011825	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
290397011826	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
290397011827	active site
290397011828	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
290397011829	nudix motif; other site
290397011830	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290397011831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
290397011832	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397011833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011834	active site
290397011835	phosphorylation site [posttranslational modification]
290397011836	intermolecular recognition site; other site
290397011837	dimerization interface [polypeptide binding]; other site
290397011838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397011839	Walker A motif; other site
290397011840	ATP binding site [chemical binding]; other site
290397011841	Walker B motif; other site
290397011842	arginine finger; other site
290397011843	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397011844	FtsH Extracellular; Region: FtsH_ext; pfam06480
290397011845	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290397011846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397011847	Walker A motif; other site
290397011848	ATP binding site [chemical binding]; other site
290397011849	Walker B motif; other site
290397011850	arginine finger; other site
290397011851	Peptidase family M41; Region: Peptidase_M41; pfam01434
290397011852	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
290397011853	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
290397011854	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
290397011855	putative active site [active]
290397011856	catalytic site [active]
290397011857	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
290397011858	putative active site [active]
290397011859	catalytic site [active]
290397011860	PilZ domain; Region: PilZ; pfam07238
290397011861	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
290397011862	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
290397011863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290397011864	dimerization interface [polypeptide binding]; other site
290397011865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397011866	dimer interface [polypeptide binding]; other site
290397011867	phosphorylation site [posttranslational modification]
290397011868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011869	ATP binding site [chemical binding]; other site
290397011870	Mg2+ binding site [ion binding]; other site
290397011871	G-X-G motif; other site
290397011872	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
290397011873	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290397011874	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290397011875	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
290397011876	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290397011877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397011878	ATP binding site [chemical binding]; other site
290397011879	Mg2+ binding site [ion binding]; other site
290397011880	G-X-G motif; other site
290397011881	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
290397011882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011883	active site
290397011884	phosphorylation site [posttranslational modification]
290397011885	intermolecular recognition site; other site
290397011886	dimerization interface [polypeptide binding]; other site
290397011887	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397011888	Walker A motif; other site
290397011889	ATP binding site [chemical binding]; other site
290397011890	Walker B motif; other site
290397011891	arginine finger; other site
290397011892	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290397011893	glutamine synthetase, type I; Region: GlnA; TIGR00653
290397011894	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
290397011895	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
290397011896	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290397011897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290397011898	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290397011899	putative substrate translocation pore; other site
290397011900	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
290397011901	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
290397011902	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
290397011903	Walker A/P-loop; other site
290397011904	ATP binding site [chemical binding]; other site
290397011905	Q-loop/lid; other site
290397011906	ABC transporter signature motif; other site
290397011907	Walker B; other site
290397011908	D-loop; other site
290397011909	H-loop/switch region; other site
290397011910	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
290397011911	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
290397011912	Walker A/P-loop; other site
290397011913	ATP binding site [chemical binding]; other site
290397011914	Q-loop/lid; other site
290397011915	ABC transporter signature motif; other site
290397011916	Walker B; other site
290397011917	D-loop; other site
290397011918	H-loop/switch region; other site
290397011919	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
290397011920	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
290397011921	TM-ABC transporter signature motif; other site
290397011922	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290397011923	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
290397011924	TM-ABC transporter signature motif; other site
290397011925	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
290397011926	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
290397011927	putative ligand binding site [chemical binding]; other site
290397011928	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290397011929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397011930	active site
290397011931	phosphorylation site [posttranslational modification]
290397011932	intermolecular recognition site; other site
290397011933	dimerization interface [polypeptide binding]; other site
290397011934	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
290397011935	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
290397011936	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
290397011937	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
290397011938	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
290397011939	Protein of unknown function DUF58; Region: DUF58; pfam01882
290397011940	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
290397011941	GIY-YIG motif/motif A; other site
290397011942	putative active site [active]
290397011943	putative metal binding site [ion binding]; other site
290397011944	MoxR-like ATPases [General function prediction only]; Region: COG0714
290397011945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290397011946	Walker A motif; other site
290397011947	ATP binding site [chemical binding]; other site
290397011948	Walker B motif; other site
290397011949	arginine finger; other site
290397011950	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
290397011951	Zn binding site [ion binding]; other site
290397011952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397011953	TPR motif; other site
290397011954	binding surface
290397011955	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290397011956	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290397011957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290397011958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290397011959	DNA binding residues [nucleotide binding]
290397011960	tyrosine kinase; Provisional; Region: PRK11519
290397011961	Chain length determinant protein; Region: Wzz; pfam02706
290397011962	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
290397011963	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290397011964	Nucleotide binding site [chemical binding]; other site
290397011965	P loop; other site
290397011966	DTAP/Switch II; other site
290397011967	Switch I; other site
290397011968	polysaccharide export protein Wza; Provisional; Region: PRK15078
290397011969	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
290397011970	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290397011971	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
290397011972	active site
290397011973	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
290397011974	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
290397011975	Mg++ binding site [ion binding]; other site
290397011976	putative catalytic motif [active]
290397011977	substrate binding site [chemical binding]; other site
290397011978	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
290397011979	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
290397011980	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290397011981	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
290397011982	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290397011983	active site
290397011984	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
290397011985	homodimer interface [polypeptide binding]; other site
290397011986	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
290397011987	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
290397011988	trimer interface [polypeptide binding]; other site
290397011989	active site
290397011990	substrate binding site [chemical binding]; other site
290397011991	CoA binding site [chemical binding]; other site
290397011992	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
290397011993	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
290397011994	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
290397011995	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
290397011996	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
290397011997	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
290397011998	NADP binding site [chemical binding]; other site
290397011999	active site
290397012000	putative substrate binding site [chemical binding]; other site
290397012001	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
290397012002	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
290397012003	NADP-binding site; other site
290397012004	homotetramer interface [polypeptide binding]; other site
290397012005	substrate binding site [chemical binding]; other site
290397012006	homodimer interface [polypeptide binding]; other site
290397012007	active site
290397012008	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
290397012009	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
290397012010	NAD binding site [chemical binding]; other site
290397012011	substrate binding site [chemical binding]; other site
290397012012	homodimer interface [polypeptide binding]; other site
290397012013	active site
290397012014	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
290397012015	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
290397012016	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
290397012017	substrate binding site; other site
290397012018	tetramer interface; other site
290397012019	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
290397012020	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
290397012021	NADP binding site [chemical binding]; other site
290397012022	active site
290397012023	putative substrate binding site [chemical binding]; other site
290397012024	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
290397012025	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
290397012026	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290397012027	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
290397012028	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
290397012029	Ligand binding site; other site
290397012030	Putative Catalytic site; other site
290397012031	DXD motif; other site
290397012032	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290397012033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290397012034	S-adenosylmethionine binding site [chemical binding]; other site
290397012035	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
290397012036	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
290397012037	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
290397012038	inhibitor-cofactor binding pocket; inhibition site
290397012039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397012040	catalytic residue [active]
290397012041	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
290397012042	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
290397012043	substrate binding site; other site
290397012044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397012045	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290397012046	NAD(P) binding site [chemical binding]; other site
290397012047	active site
290397012048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397012049	active site
290397012050	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
290397012051	metal-binding site
290397012052	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290397012053	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290397012054	active site
290397012055	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
290397012056	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290397012057	active site
290397012058	homodimer interface [polypeptide binding]; other site
290397012059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290397012060	TIGR01777 family protein; Region: yfcH
290397012061	NAD(P) binding site [chemical binding]; other site
290397012062	active site
290397012063	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
290397012064	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290397012065	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
290397012066	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
290397012067	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
290397012068	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
290397012069	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290397012070	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290397012071	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290397012072	PAS domain; Region: PAS_9; pfam13426
290397012073	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
290397012074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397012075	dimer interface [polypeptide binding]; other site
290397012076	phosphorylation site [posttranslational modification]
290397012077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397012078	ATP binding site [chemical binding]; other site
290397012079	Mg2+ binding site [ion binding]; other site
290397012080	G-X-G motif; other site
290397012081	Protein of unknown function DUF111; Region: DUF111; pfam01969
290397012082	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
290397012083	AIR carboxylase; Region: AIRC; smart01001
290397012084	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
290397012085	Chemotaxis phosphatase CheX; Region: CheX; cl15816
290397012086	Chemotaxis phosphatase CheX; Region: CheX; cl15816
290397012087	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290397012088	putative binding surface; other site
290397012089	active site
290397012090	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
290397012091	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
290397012092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397012093	ATP binding site [chemical binding]; other site
290397012094	Mg2+ binding site [ion binding]; other site
290397012095	G-X-G motif; other site
290397012096	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
290397012097	Response regulator receiver domain; Region: Response_reg; pfam00072
290397012098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290397012099	active site
290397012100	phosphorylation site [posttranslational modification]
290397012101	intermolecular recognition site; other site
290397012102	dimerization interface [polypeptide binding]; other site
290397012103	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
290397012104	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
290397012105	dimerization interface [polypeptide binding]; other site
290397012106	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
290397012107	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
290397012108	dimer interface [polypeptide binding]; other site
290397012109	putative CheW interface [polypeptide binding]; other site
290397012110	thiamine monophosphate kinase; Provisional; Region: PRK05731
290397012111	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
290397012112	ATP binding site [chemical binding]; other site
290397012113	dimerization interface [polypeptide binding]; other site
290397012114	Sensory domain found in PocR; Region: PocR; pfam10114
290397012115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290397012116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290397012117	dimer interface [polypeptide binding]; other site
290397012118	phosphorylation site [posttranslational modification]
290397012119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290397012120	ATP binding site [chemical binding]; other site
290397012121	Mg2+ binding site [ion binding]; other site
290397012122	G-X-G motif; other site
290397012123	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
290397012124	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
290397012125	G1 box; other site
290397012126	GTP/Mg2+ binding site [chemical binding]; other site
290397012127	G2 box; other site
290397012128	Switch I region; other site
290397012129	G3 box; other site
290397012130	Switch II region; other site
290397012131	G4 box; other site
290397012132	G5 box; other site
290397012133	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
290397012134	DEAD/DEAH box helicase; Region: DEAD; pfam00270
290397012135	DEAD_2; Region: DEAD_2; pfam06733
290397012136	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
290397012137	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
290397012138	Peptidase family M50; Region: Peptidase_M50; pfam02163
290397012139	active site
290397012140	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290397012141	putative substrate binding region [chemical binding]; other site
290397012142	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
290397012143	putative ligand binding site [chemical binding]; other site
290397012144	chaperone protein DnaJ; Provisional; Region: PRK10767
290397012145	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290397012146	HSP70 interaction site [polypeptide binding]; other site
290397012147	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
290397012148	substrate binding site [polypeptide binding]; other site
290397012149	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
290397012150	Zn binding sites [ion binding]; other site
290397012151	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
290397012152	dimer interface [polypeptide binding]; other site
290397012153	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
290397012154	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
290397012155	nucleotide binding site [chemical binding]; other site
290397012156	NEF interaction site [polypeptide binding]; other site
290397012157	SBD interface [polypeptide binding]; other site
290397012158	GrpE; Region: GrpE; pfam01025
290397012159	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
290397012160	dimer interface [polypeptide binding]; other site
290397012161	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
290397012162	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
290397012163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290397012164	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290397012165	binding surface
290397012166	TPR motif; other site
290397012167	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
290397012168	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
290397012169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290397012170	ATP binding site [chemical binding]; other site
290397012171	putative Mg++ binding site [ion binding]; other site
290397012172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290397012173	nucleotide binding region [chemical binding]; other site
290397012174	ATP-binding site [chemical binding]; other site
290397012175	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
290397012176	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290397012177	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
290397012178	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290397012179	SurA N-terminal domain; Region: SurA_N; pfam09312
290397012180	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290397012181	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
290397012182	GTP-binding protein YchF; Reviewed; Region: PRK09601
290397012183	YchF GTPase; Region: YchF; cd01900
290397012184	G1 box; other site
290397012185	GTP/Mg2+ binding site [chemical binding]; other site
290397012186	Switch I region; other site
290397012187	G2 box; other site
290397012188	Switch II region; other site
290397012189	G3 box; other site
290397012190	G4 box; other site
290397012191	G5 box; other site
290397012192	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
290397012193	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
290397012194	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
290397012195	ATP synthase subunit C; Region: ATP-synt_C; cl00466
290397012196	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
290397012197	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
290397012198	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290397012199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290397012200	catalytic residue [active]
290397012201	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
290397012202	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290397012203	inhibitor-cofactor binding pocket; inhibition site
290397012204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290397012205	catalytic residue [active]
290397012206	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
290397012207	DNA gyrase subunit A; Validated; Region: PRK05560
290397012208	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
290397012209	CAP-like domain; other site
290397012210	active site
290397012211	primary dimer interface [polypeptide binding]; other site
290397012212	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290397012213	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290397012214	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290397012215	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290397012216	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
290397012217	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
290397012218	gamma subunit interface [polypeptide binding]; other site
290397012219	epsilon subunit interface [polypeptide binding]; other site
290397012220	LBP interface [polypeptide binding]; other site
290397012221	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
290397012222	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290397012223	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
290397012224	alpha subunit interaction interface [polypeptide binding]; other site
290397012225	Walker A motif; other site
290397012226	ATP binding site [chemical binding]; other site
290397012227	Walker B motif; other site
290397012228	inhibitor binding site; inhibition site
290397012229	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290397012230	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
290397012231	core domain interface [polypeptide binding]; other site
290397012232	delta subunit interface [polypeptide binding]; other site
290397012233	epsilon subunit interface [polypeptide binding]; other site
290397012234	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
290397012235	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290397012236	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
290397012237	beta subunit interaction interface [polypeptide binding]; other site
290397012238	Walker A motif; other site
290397012239	ATP binding site [chemical binding]; other site
290397012240	Walker B motif; other site
290397012241	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290397012242	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
290397012243	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
290397012244	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290397012245	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
290397012246	putative dimer interface [polypeptide binding]; other site
290397012247	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
290397012248	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
290397012249	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
290397012250	ParB-like nuclease domain; Region: ParB; smart00470
290397012251	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290397012252	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290397012253	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290397012254	Magnesium ion binding site [ion binding]; other site
290397012255	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
290397012256	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
290397012257	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
290397012258	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
290397012259	RxxxH motif; other site
290397012260	membrane protein insertase; Provisional; Region: PRK01318
290397012261	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
290397012262	Haemolytic domain; Region: Haemolytic; pfam01809
290397012263	Ribonuclease P; Region: Ribonuclease_P; pfam00825
290397012264	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399