-- dump date 20140618_204158 -- class Genbank::misc_feature -- table misc_feature_note -- id note 320483000001 AIR carboxylase; Region: AIRC; pfam00731 320483000002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320483000003 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 320483000004 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 320483000005 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320483000006 IHF - DNA interface [nucleotide binding]; other site 320483000007 IHF dimer interface [polypeptide binding]; other site 320483000008 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 320483000009 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 320483000010 DNA binding residues [nucleotide binding] 320483000011 ribonuclease E; Reviewed; Region: rne; PRK10811 320483000012 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 320483000013 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320483000014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320483000015 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320483000016 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 320483000017 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 320483000018 active site 320483000019 HIGH motif; other site 320483000020 dimer interface [polypeptide binding]; other site 320483000021 KMSKS motif; other site 320483000022 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483000023 GrpE; Region: GrpE; pfam01025 320483000024 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 320483000025 dimer interface [polypeptide binding]; other site 320483000026 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 320483000027 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 320483000028 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 320483000029 catalytic motif [active] 320483000030 Zn binding site [ion binding]; other site 320483000031 RibD C-terminal domain; Region: RibD_C; cl17279 320483000032 CTP synthetase; Validated; Region: pyrG; PRK05380 320483000033 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 320483000034 Catalytic site [active] 320483000035 active site 320483000036 UTP binding site [chemical binding]; other site 320483000037 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 320483000038 active site 320483000039 putative oxyanion hole; other site 320483000040 catalytic triad [active] 320483000041 Preprotein translocase SecG subunit; Region: SecG; pfam03840 320483000042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320483000043 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 320483000044 active site 320483000045 DNA binding site [nucleotide binding] 320483000046 Int/Topo IB signature motif; other site 320483000047 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320483000048 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320483000049 Walker A/P-loop; other site 320483000050 ATP binding site [chemical binding]; other site 320483000051 Q-loop/lid; other site 320483000052 ABC transporter signature motif; other site 320483000053 Walker B; other site 320483000054 D-loop; other site 320483000055 H-loop/switch region; other site 320483000056 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 320483000057 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320483000058 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320483000059 putative NAD(P) binding site [chemical binding]; other site 320483000060 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 320483000061 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12662 320483000062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483000063 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000064 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 320483000065 thiS-thiF/thiG interaction site; other site 320483000066 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 320483000067 ThiS interaction site; other site 320483000068 putative active site [active] 320483000069 tetramer interface [polypeptide binding]; other site 320483000070 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 320483000071 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 320483000072 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483000073 active site 320483000074 HIGH motif; other site 320483000075 nucleotide binding site [chemical binding]; other site 320483000076 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320483000077 active site 320483000078 KMSKS motif; other site 320483000079 SurA N-terminal domain; Region: SurA_N_3; cl07813 320483000080 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 320483000081 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 320483000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483000083 S-adenosylmethionine binding site [chemical binding]; other site 320483000084 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000086 metabolite-proton symporter; Region: 2A0106; TIGR00883 320483000087 putative substrate translocation pore; other site 320483000088 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 320483000089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320483000090 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 320483000091 active site 320483000092 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 320483000093 active site 320483000094 substrate binding site [chemical binding]; other site 320483000095 CoA binding site [chemical binding]; other site 320483000096 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 320483000097 NADP binding site [chemical binding]; other site 320483000098 substrate binding pocket [chemical binding]; other site 320483000099 active site 320483000100 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 320483000101 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 320483000102 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 320483000103 dimer interface [polypeptide binding]; other site 320483000104 motif 1; other site 320483000105 active site 320483000106 motif 2; other site 320483000107 motif 3; other site 320483000108 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 320483000109 23S rRNA binding site [nucleotide binding]; other site 320483000110 L21 binding site [polypeptide binding]; other site 320483000111 L13 binding site [polypeptide binding]; other site 320483000112 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 320483000113 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 320483000114 transcription termination factor Rho; Provisional; Region: rho; PRK09376 320483000115 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 320483000116 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 320483000117 RNA binding site [nucleotide binding]; other site 320483000118 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 320483000119 multimer interface [polypeptide binding]; other site 320483000120 Walker A motif; other site 320483000121 ATP binding site [chemical binding]; other site 320483000122 Walker B motif; other site 320483000123 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000124 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320483000125 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320483000126 Uncharacterized conserved protein [Function unknown]; Region: COG2835 320483000127 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 320483000128 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 320483000129 ATP cone domain; Region: ATP-cone; pfam03477 320483000130 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; pfam05071 320483000131 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 320483000132 mce related protein; Region: MCE; pfam02470 320483000133 Surface antigen; Region: Surface_Ag_2; pfam01617 320483000134 Surface antigen; Region: Surface_Ag_2; pfam01617 320483000135 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000136 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000137 recombinase A; Provisional; Region: recA; PRK09354 320483000138 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 320483000139 hexamer interface [polypeptide binding]; other site 320483000140 Walker A motif; other site 320483000141 ATP binding site [chemical binding]; other site 320483000142 Walker B motif; other site 320483000143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320483000144 active site 320483000145 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 320483000146 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 320483000147 ATP binding site [chemical binding]; other site 320483000148 substrate interface [chemical binding]; other site 320483000149 Surface antigen; Region: Surface_Ag_2; pfam01617 320483000150 Membrane transport protein; Region: Mem_trans; cl09117 320483000151 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 320483000152 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 320483000153 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320483000154 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320483000155 catalytic residues [active] 320483000156 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 320483000157 VirB7 interaction site; other site 320483000158 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 320483000159 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 320483000160 tetramer interface [polypeptide binding]; other site 320483000161 TPP-binding site [chemical binding]; other site 320483000162 heterodimer interface [polypeptide binding]; other site 320483000163 phosphorylation loop region [posttranslational modification] 320483000164 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320483000165 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320483000166 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 320483000167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 320483000168 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 320483000169 active site 320483000170 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 320483000171 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 320483000172 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320483000173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320483000174 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 320483000175 thymidylate kinase; Validated; Region: tmk; PRK00698 320483000176 TMP-binding site; other site 320483000177 ATP-binding site [chemical binding]; other site 320483000178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000179 putative substrate translocation pore; other site 320483000180 Tim44-like domain; Region: Tim44; pfam04280 320483000181 preprotein translocase subunit SecB; Validated; Region: PRK05751 320483000182 SecA binding site; other site 320483000183 Preprotein binding site; other site 320483000184 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 320483000185 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 320483000186 catalytic residues [active] 320483000187 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 320483000188 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 320483000189 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 320483000190 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 320483000191 Peptidase family M23; Region: Peptidase_M23; pfam01551 320483000192 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320483000193 FMN binding site [chemical binding]; other site 320483000194 substrate binding site [chemical binding]; other site 320483000195 putative catalytic residue [active] 320483000196 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 320483000197 Lumazine binding domain; Region: Lum_binding; pfam00677 320483000198 Lumazine binding domain; Region: Lum_binding; pfam00677 320483000199 Major surface protein 1B; Region: MSP1b; pfam03429 320483000200 Major surface protein 1B; Region: MSP1b; pfam03429 320483000201 Major surface protein 1B; Region: MSP1b; pfam03429 320483000202 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 320483000203 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 320483000204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320483000205 ATP binding site [chemical binding]; other site 320483000206 putative Mg++ binding site [ion binding]; other site 320483000207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320483000208 nucleotide binding region [chemical binding]; other site 320483000209 ATP-binding site [chemical binding]; other site 320483000210 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 320483000211 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 320483000212 RNA/DNA hybrid binding site [nucleotide binding]; other site 320483000213 active site 320483000214 Protein of unknown function; Region: DUF3971; pfam13116 320483000215 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 320483000216 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 320483000217 putative nucleotide binding site [chemical binding]; other site 320483000218 uridine monophosphate binding site [chemical binding]; other site 320483000219 homohexameric interface [polypeptide binding]; other site 320483000220 ribosome recycling factor; Reviewed; Region: frr; PRK00083 320483000221 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 320483000222 hinge region; other site 320483000223 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 320483000224 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 320483000225 catalytic residue [active] 320483000226 putative FPP diphosphate binding site; other site 320483000227 putative FPP binding hydrophobic cleft; other site 320483000228 dimer interface [polypeptide binding]; other site 320483000229 putative IPP diphosphate binding site; other site 320483000230 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 320483000231 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 320483000232 Major surface protein 1B; Region: MSP1b; pfam03429 320483000233 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 320483000234 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 320483000235 ATP binding site [chemical binding]; other site 320483000236 active site 320483000237 substrate binding site [chemical binding]; other site 320483000238 histidyl-tRNA synthetase; Region: hisS; TIGR00442 320483000239 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 320483000240 dimer interface [polypeptide binding]; other site 320483000241 motif 1; other site 320483000242 active site 320483000243 motif 2; other site 320483000244 motif 3; other site 320483000245 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 320483000246 anticodon binding site; other site 320483000247 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 320483000248 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 320483000249 catalytic residues [active] 320483000250 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 320483000251 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 320483000252 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 320483000253 oligomerization interface [polypeptide binding]; other site 320483000254 active site 320483000255 metal binding site [ion binding]; metal-binding site 320483000256 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 320483000257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483000258 Walker A/P-loop; other site 320483000259 ATP binding site [chemical binding]; other site 320483000260 Q-loop/lid; other site 320483000261 ABC transporter signature motif; other site 320483000262 Walker B; other site 320483000263 D-loop; other site 320483000264 H-loop/switch region; other site 320483000265 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 320483000266 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 320483000267 hinge; other site 320483000268 active site 320483000269 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320483000270 trimer interface [polypeptide binding]; other site 320483000271 active site 320483000272 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 320483000273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320483000274 putative NAD(P) binding site [chemical binding]; other site 320483000275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320483000276 DNA-binding site [nucleotide binding]; DNA binding site 320483000277 RNA-binding motif; other site 320483000278 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 320483000279 HAMP domain; Region: HAMP; pfam00672 320483000280 dimerization interface [polypeptide binding]; other site 320483000281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320483000282 dimer interface [polypeptide binding]; other site 320483000283 phosphorylation site [posttranslational modification] 320483000284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483000285 ATP binding site [chemical binding]; other site 320483000286 Mg2+ binding site [ion binding]; other site 320483000287 G-X-G motif; other site 320483000288 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 320483000289 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 320483000290 catalytic site [active] 320483000291 putative active site [active] 320483000292 putative substrate binding site [chemical binding]; other site 320483000293 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 320483000294 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 320483000295 nucleotide binding pocket [chemical binding]; other site 320483000296 K-X-D-G motif; other site 320483000297 catalytic site [active] 320483000298 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 320483000299 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 320483000300 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 320483000301 Dimer interface [polypeptide binding]; other site 320483000302 BRCT sequence motif; other site 320483000303 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 320483000304 putative GSH binding site [chemical binding]; other site 320483000305 catalytic residues [active] 320483000306 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 320483000307 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 320483000308 catalytic residues [active] 320483000309 central insert; other site 320483000310 DNA repair protein RadA; Provisional; Region: PRK11823 320483000311 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320483000312 Walker A motif; other site 320483000313 ATP binding site [chemical binding]; other site 320483000314 Walker B motif; other site 320483000315 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320483000316 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 320483000317 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 320483000318 Colicin V production protein; Region: Colicin_V; pfam02674 320483000319 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 320483000320 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 320483000321 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 320483000322 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 320483000323 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 320483000324 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 320483000325 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 320483000326 dimer interface [polypeptide binding]; other site 320483000327 active site 320483000328 glycine-pyridoxal phosphate binding site [chemical binding]; other site 320483000329 folate binding site [chemical binding]; other site 320483000330 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 320483000331 putative iron binding site [ion binding]; other site 320483000332 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 320483000333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320483000334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483000335 Walker A/P-loop; other site 320483000336 ATP binding site [chemical binding]; other site 320483000337 Q-loop/lid; other site 320483000338 ABC transporter signature motif; other site 320483000339 Walker B; other site 320483000340 D-loop; other site 320483000341 H-loop/switch region; other site 320483000342 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 320483000343 L-aspartate oxidase; Provisional; Region: PRK06175 320483000344 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 320483000345 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 320483000346 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320483000347 catalytic loop [active] 320483000348 iron binding site [ion binding]; other site 320483000349 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 320483000350 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 320483000351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000352 putative substrate translocation pore; other site 320483000353 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 320483000354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483000355 Walker A motif; other site 320483000356 ATP binding site [chemical binding]; other site 320483000357 Walker B motif; other site 320483000358 arginine finger; other site 320483000359 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 320483000360 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 320483000361 RuvA N terminal domain; Region: RuvA_N; pfam01330 320483000362 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 320483000363 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 320483000364 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 320483000365 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 320483000366 catalytic site [active] 320483000367 G-X2-G-X-G-K; other site 320483000368 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 320483000369 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 320483000370 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14187 320483000371 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 320483000372 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 320483000373 homodimer interface [polypeptide binding]; other site 320483000374 NADP binding site [chemical binding]; other site 320483000375 substrate binding site [chemical binding]; other site 320483000376 Major surface protein 1B; Region: MSP1b; pfam03429 320483000377 Major surface protein 1B; Region: MSP1b; pfam03429 320483000378 Major surface protein 1B; Region: MSP1b; pfam03429 320483000379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320483000380 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320483000381 Cytochrome c2 [Energy production and conversion]; Region: COG3474 320483000382 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 320483000383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483000384 pyruvate phosphate dikinase; Provisional; Region: PRK09279 320483000385 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 320483000386 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320483000387 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320483000388 RDD family; Region: RDD; pfam06271 320483000389 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 320483000390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320483000391 motif II; other site 320483000392 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 320483000393 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 320483000394 dimer interface [polypeptide binding]; other site 320483000395 anticodon binding site; other site 320483000396 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 320483000397 homodimer interface [polypeptide binding]; other site 320483000398 motif 1; other site 320483000399 active site 320483000400 motif 2; other site 320483000401 GAD domain; Region: GAD; pfam02938 320483000402 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 320483000403 active site 320483000404 motif 3; other site 320483000405 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320483000406 BON domain; Region: BON; pfam04972 320483000407 BON domain; Region: BON; pfam04972 320483000408 glutathione synthetase, prokaryotic; Region: glut_syn; TIGR01380 320483000409 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 320483000410 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 320483000411 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 320483000412 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 320483000413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320483000414 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 320483000415 Cell division protein FtsQ; Region: FtsQ; pfam03799 320483000416 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320483000417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320483000418 active site 320483000419 phosphorylation site [posttranslational modification] 320483000420 intermolecular recognition site; other site 320483000421 dimerization interface [polypeptide binding]; other site 320483000422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483000423 Walker A motif; other site 320483000424 ATP binding site [chemical binding]; other site 320483000425 Walker B motif; other site 320483000426 arginine finger; other site 320483000427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320483000428 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483000429 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 320483000430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320483000431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320483000432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320483000433 putative hydrolase; Provisional; Region: PRK02113 320483000434 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 320483000435 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320483000436 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 320483000437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320483000438 dimer interface [polypeptide binding]; other site 320483000439 conserved gate region; other site 320483000440 putative PBP binding loops; other site 320483000441 ABC-ATPase subunit interface; other site 320483000442 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 320483000443 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 320483000444 motif 1; other site 320483000445 active site 320483000446 motif 2; other site 320483000447 motif 3; other site 320483000448 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320483000449 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 320483000450 CoA binding domain; Region: CoA_binding; smart00881 320483000451 CoA-ligase; Region: Ligase_CoA; pfam00549 320483000452 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 320483000453 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 320483000454 CoA-ligase; Region: Ligase_CoA; pfam00549 320483000455 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320483000456 PBP superfamily domain; Region: PBP_like_2; cl17296 320483000457 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320483000458 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320483000459 Cu(I) binding site [ion binding]; other site 320483000460 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 320483000461 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320483000462 FMN binding site [chemical binding]; other site 320483000463 substrate binding site [chemical binding]; other site 320483000464 putative catalytic residue [active] 320483000465 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320483000466 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 320483000467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320483000468 dimer interface [polypeptide binding]; other site 320483000469 conserved gate region; other site 320483000470 putative PBP binding loops; other site 320483000471 ABC-ATPase subunit interface; other site 320483000472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320483000473 dimer interface [polypeptide binding]; other site 320483000474 conserved gate region; other site 320483000475 putative PBP binding loops; other site 320483000476 ABC-ATPase subunit interface; other site 320483000477 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 320483000478 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320483000479 HlyD family secretion protein; Region: HlyD_3; pfam13437 320483000480 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 320483000481 COQ9; Region: COQ9; pfam08511 320483000482 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 320483000483 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320483000484 translocation protein TolB; Provisional; Region: tolB; PRK05137 320483000485 TolB amino-terminal domain; Region: TolB_N; pfam04052 320483000486 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320483000487 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 320483000488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320483000489 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 320483000490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320483000491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320483000492 active site 320483000493 metal binding site [ion binding]; metal-binding site 320483000494 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 320483000495 S17 interaction site [polypeptide binding]; other site 320483000496 S8 interaction site; other site 320483000497 16S rRNA interaction site [nucleotide binding]; other site 320483000498 streptomycin interaction site [chemical binding]; other site 320483000499 23S rRNA interaction site [nucleotide binding]; other site 320483000500 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 320483000501 30S ribosomal protein S7; Validated; Region: PRK05302 320483000502 elongation factor G; Reviewed; Region: PRK00007 320483000503 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 320483000504 G1 box; other site 320483000505 putative GEF interaction site [polypeptide binding]; other site 320483000506 GTP/Mg2+ binding site [chemical binding]; other site 320483000507 Switch I region; other site 320483000508 G2 box; other site 320483000509 G3 box; other site 320483000510 Switch II region; other site 320483000511 G4 box; other site 320483000512 G5 box; other site 320483000513 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 320483000514 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 320483000515 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 320483000516 elongation factor Tu; Reviewed; Region: PRK00049 320483000517 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320483000518 G1 box; other site 320483000519 GEF interaction site [polypeptide binding]; other site 320483000520 GTP/Mg2+ binding site [chemical binding]; other site 320483000521 Switch I region; other site 320483000522 G2 box; other site 320483000523 G3 box; other site 320483000524 Switch II region; other site 320483000525 G4 box; other site 320483000526 G5 box; other site 320483000527 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320483000528 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320483000529 Antibiotic Binding Site [chemical binding]; other site 320483000530 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 320483000531 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 320483000532 putative homodimer interface [polypeptide binding]; other site 320483000533 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 320483000534 heterodimer interface [polypeptide binding]; other site 320483000535 homodimer interface [polypeptide binding]; other site 320483000536 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 320483000537 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 320483000538 23S rRNA interface [nucleotide binding]; other site 320483000539 L7/L12 interface [polypeptide binding]; other site 320483000540 putative thiostrepton binding site; other site 320483000541 L25 interface [polypeptide binding]; other site 320483000542 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 320483000543 mRNA/rRNA interface [nucleotide binding]; other site 320483000544 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 320483000545 23S rRNA interface [nucleotide binding]; other site 320483000546 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 320483000547 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 320483000548 peripheral dimer interface [polypeptide binding]; other site 320483000549 core dimer interface [polypeptide binding]; other site 320483000550 L10 interface [polypeptide binding]; other site 320483000551 L11 interface [polypeptide binding]; other site 320483000552 putative EF-Tu interaction site [polypeptide binding]; other site 320483000553 putative EF-G interaction site [polypeptide binding]; other site 320483000554 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 320483000555 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 320483000556 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320483000557 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 320483000558 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320483000559 RPB3 interaction site [polypeptide binding]; other site 320483000560 RPB1 interaction site [polypeptide binding]; other site 320483000561 RPB11 interaction site [polypeptide binding]; other site 320483000562 RPB10 interaction site [polypeptide binding]; other site 320483000563 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 320483000564 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 320483000565 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 320483000566 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 320483000567 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 320483000568 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 320483000569 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 320483000570 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 320483000571 DNA binding site [nucleotide binding] 320483000572 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 320483000573 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 320483000574 RNA/DNA hybrid binding site [nucleotide binding]; other site 320483000575 active site 320483000576 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 320483000577 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 320483000578 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320483000579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320483000580 catalytic residue [active] 320483000581 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 320483000582 pantothenate kinase; Reviewed; Region: PRK13318 320483000583 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 320483000584 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 320483000585 quinone interaction residues [chemical binding]; other site 320483000586 active site 320483000587 catalytic residues [active] 320483000588 FMN binding site [chemical binding]; other site 320483000589 substrate binding site [chemical binding]; other site 320483000590 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320483000591 active site 320483000592 catalytic residues [active] 320483000593 metal binding site [ion binding]; metal-binding site 320483000594 Predicted esterase [General function prediction only]; Region: COG0400 320483000595 putative hydrolase; Provisional; Region: PRK11460 320483000596 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 320483000597 active site 320483000598 nucleophile elbow; other site 320483000599 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 320483000600 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 320483000601 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 320483000602 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 320483000603 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320483000604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320483000605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320483000606 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 320483000607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320483000608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320483000609 catalytic residue [active] 320483000610 BolA-like protein; Region: BolA; pfam01722 320483000611 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 320483000612 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 320483000613 putative active site [active] 320483000614 putative PHP Thumb interface [polypeptide binding]; other site 320483000615 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 320483000616 generic binding surface I; other site 320483000617 generic binding surface II; other site 320483000618 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 320483000619 putative active site [active] 320483000620 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 320483000621 Iron-sulfur protein interface; other site 320483000622 proximal quinone binding site [chemical binding]; other site 320483000623 SdhD (CybS) interface [polypeptide binding]; other site 320483000624 proximal heme binding site [chemical binding]; other site 320483000625 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 320483000626 putative SdhC subunit interface [polypeptide binding]; other site 320483000627 putative proximal heme binding site [chemical binding]; other site 320483000628 putative Iron-sulfur protein interface [polypeptide binding]; other site 320483000629 putative proximal quinone binding site; other site 320483000630 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320483000631 dimer interface [polypeptide binding]; other site 320483000632 substrate binding site [chemical binding]; other site 320483000633 ATP binding site [chemical binding]; other site 320483000634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320483000635 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 320483000636 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320483000637 Domain of unknown function DUF20; Region: UPF0118; pfam01594 320483000638 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 320483000639 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 320483000640 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 320483000641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320483000642 RNA binding surface [nucleotide binding]; other site 320483000643 PAS fold; Region: PAS_7; pfam12860 320483000644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320483000645 Coenzyme A binding pocket [chemical binding]; other site 320483000646 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 320483000647 tetramer interfaces [polypeptide binding]; other site 320483000648 binuclear metal-binding site [ion binding]; other site 320483000649 trigger factor; Region: tig; TIGR00115 320483000650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320483000651 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 320483000652 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 320483000653 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 320483000654 oligomer interface [polypeptide binding]; other site 320483000655 active site residues [active] 320483000656 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 320483000657 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 320483000658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483000659 Walker A motif; other site 320483000660 ATP binding site [chemical binding]; other site 320483000661 Walker B motif; other site 320483000662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320483000663 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 320483000664 Found in ATP-dependent protease La (LON); Region: LON; smart00464 320483000665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483000666 Walker A motif; other site 320483000667 ATP binding site [chemical binding]; other site 320483000668 Walker B motif; other site 320483000669 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 320483000670 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 320483000671 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 320483000672 putative active site [active] 320483000673 substrate binding site [chemical binding]; other site 320483000674 putative cosubstrate binding site; other site 320483000675 catalytic site [active] 320483000676 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 320483000677 substrate binding site [chemical binding]; other site 320483000678 hypothetical protein; Validated; Region: PRK01415 320483000679 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 320483000680 active site residue [active] 320483000681 PEP synthetase regulatory protein; Provisional; Region: PRK05339 320483000682 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 320483000683 thiamine phosphate binding site [chemical binding]; other site 320483000684 active site 320483000685 pyrophosphate binding site [ion binding]; other site 320483000686 Domain of unknown function DUF21; Region: DUF21; pfam01595 320483000687 gliding motility-associated protein GldE; Region: GldE; TIGR03520 320483000688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320483000689 Transporter associated domain; Region: CorC_HlyC; smart01091 320483000690 YGGT family; Region: YGGT; pfam02325 320483000691 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 320483000692 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 320483000693 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 320483000694 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 320483000695 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 320483000696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320483000697 inhibitor-cofactor binding pocket; inhibition site 320483000698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320483000699 catalytic residue [active] 320483000700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320483000701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320483000702 dimer interface [polypeptide binding]; other site 320483000703 phosphorylation site [posttranslational modification] 320483000704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483000705 ATP binding site [chemical binding]; other site 320483000706 Mg2+ binding site [ion binding]; other site 320483000707 G-X-G motif; other site 320483000708 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320483000709 TolR protein; Region: tolR; TIGR02801 320483000710 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 320483000711 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 320483000712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483000713 ATP binding site [chemical binding]; other site 320483000714 Mg2+ binding site [ion binding]; other site 320483000715 G-X-G motif; other site 320483000716 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 320483000717 ATP binding site [chemical binding]; other site 320483000718 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 320483000719 DNA protecting protein DprA; Region: dprA; TIGR00732 320483000720 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 320483000721 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 320483000722 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 320483000723 Ligand Binding Site [chemical binding]; other site 320483000724 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320483000725 Walker A motif; other site 320483000726 ATP binding site [chemical binding]; other site 320483000727 Walker B motif; other site 320483000728 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 320483000729 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 320483000730 dimer interface [polypeptide binding]; other site 320483000731 active site 320483000732 acyl carrier protein; Provisional; Region: acpP; PRK00982 320483000733 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 320483000734 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 320483000735 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 320483000736 diiron binding motif [ion binding]; other site 320483000737 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 320483000738 Part of AAA domain; Region: AAA_19; pfam13245 320483000739 Family description; Region: UvrD_C_2; pfam13538 320483000740 DNA gyrase subunit A; Validated; Region: PRK05560 320483000741 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 320483000742 CAP-like domain; other site 320483000743 active site 320483000744 primary dimer interface [polypeptide binding]; other site 320483000745 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320483000746 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320483000747 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320483000748 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320483000749 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 320483000750 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320483000751 minor groove reading motif; other site 320483000752 helix-hairpin-helix signature motif; other site 320483000753 substrate binding pocket [chemical binding]; other site 320483000754 active site 320483000755 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 320483000756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 320483000757 heat shock protein 90; Provisional; Region: PRK05218 320483000758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483000759 ATP binding site [chemical binding]; other site 320483000760 Mg2+ binding site [ion binding]; other site 320483000761 G-X-G motif; other site 320483000762 adenylosuccinate lyase; Provisional; Region: PRK07492 320483000763 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 320483000764 tetramer interface [polypeptide binding]; other site 320483000765 active site 320483000766 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 320483000767 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 320483000768 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 320483000769 GIY-YIG motif/motif A; other site 320483000770 active site 320483000771 catalytic site [active] 320483000772 putative DNA binding site [nucleotide binding]; other site 320483000773 metal binding site [ion binding]; metal-binding site 320483000774 UvrB/uvrC motif; Region: UVR; pfam02151 320483000775 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 320483000776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 320483000777 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 320483000778 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 320483000779 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 320483000780 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320483000781 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320483000782 C-terminal domain interface [polypeptide binding]; other site 320483000783 GSH binding site (G-site) [chemical binding]; other site 320483000784 dimer interface [polypeptide binding]; other site 320483000785 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 320483000786 N-terminal domain interface [polypeptide binding]; other site 320483000787 dimer interface [polypeptide binding]; other site 320483000788 substrate binding pocket (H-site) [chemical binding]; other site 320483000789 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 320483000790 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320483000791 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320483000792 Walker A/P-loop; other site 320483000793 ATP binding site [chemical binding]; other site 320483000794 Q-loop/lid; other site 320483000795 ABC transporter signature motif; other site 320483000796 Walker B; other site 320483000797 D-loop; other site 320483000798 H-loop/switch region; other site 320483000799 TOBE domain; Region: TOBE_2; pfam08402 320483000800 recombination protein RecR; Reviewed; Region: recR; PRK00076 320483000801 RecR protein; Region: RecR; pfam02132 320483000802 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 320483000803 putative active site [active] 320483000804 putative metal-binding site [ion binding]; other site 320483000805 tetramer interface [polypeptide binding]; other site 320483000806 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 320483000807 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 320483000808 metal binding site [ion binding]; metal-binding site 320483000809 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 320483000810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483000811 Walker A/P-loop; other site 320483000812 ATP binding site [chemical binding]; other site 320483000813 Q-loop/lid; other site 320483000814 ABC transporter signature motif; other site 320483000815 Walker B; other site 320483000816 D-loop; other site 320483000817 H-loop/switch region; other site 320483000818 ABC1 family; Region: ABC1; cl17513 320483000819 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 320483000820 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 320483000821 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 320483000822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320483000823 FeS/SAM binding site; other site 320483000824 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 320483000825 Putative phage tail protein; Region: Phage-tail_3; pfam13550 320483000826 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 320483000827 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 320483000828 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 320483000829 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 320483000830 TPP-binding site [chemical binding]; other site 320483000831 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 320483000832 dimer interface [polypeptide binding]; other site 320483000833 PYR/PP interface [polypeptide binding]; other site 320483000834 TPP binding site [chemical binding]; other site 320483000835 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 320483000836 Phage capsid family; Region: Phage_capsid; pfam05065 320483000837 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 320483000838 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 320483000839 dimer interface [polypeptide binding]; other site 320483000840 active site 320483000841 catalytic residue [active] 320483000842 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 320483000843 nucleotide binding site/active site [active] 320483000844 HIT family signature motif; other site 320483000845 catalytic residue [active] 320483000846 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 320483000847 MutS domain I; Region: MutS_I; pfam01624 320483000848 MutS domain II; Region: MutS_II; pfam05188 320483000849 MutS domain III; Region: MutS_III; pfam05192 320483000850 MutS domain V; Region: MutS_V; pfam00488 320483000851 Walker A/P-loop; other site 320483000852 ATP binding site [chemical binding]; other site 320483000853 Q-loop/lid; other site 320483000854 ABC transporter signature motif; other site 320483000855 Walker B; other site 320483000856 D-loop; other site 320483000857 H-loop/switch region; other site 320483000858 metabolite-proton symporter; Region: 2A0106; TIGR00883 320483000859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000860 putative substrate translocation pore; other site 320483000861 metabolite-proton symporter; Region: 2A0106; TIGR00883 320483000862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000863 putative substrate translocation pore; other site 320483000864 NAD synthetase; Provisional; Region: PRK13981 320483000865 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 320483000866 catalytic triad [active] 320483000867 dimer interface [polypeptide binding]; other site 320483000868 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 320483000869 homodimer interface [polypeptide binding]; other site 320483000870 NAD binding pocket [chemical binding]; other site 320483000871 ATP binding pocket [chemical binding]; other site 320483000872 Mg binding site [ion binding]; other site 320483000873 active-site loop [active] 320483000874 Delta-aminolevulinic acid dehydratase; Region: ALAD; smart01004 320483000875 dimer interface [polypeptide binding]; other site 320483000876 active site 320483000877 Schiff base residues; other site 320483000878 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 320483000879 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320483000880 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320483000881 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 320483000882 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 320483000883 metabolite-proton symporter; Region: 2A0106; TIGR00883 320483000884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320483000885 putative substrate translocation pore; other site 320483000886 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 320483000887 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 320483000888 dimer interface [polypeptide binding]; other site 320483000889 ssDNA binding site [nucleotide binding]; other site 320483000890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320483000891 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 320483000892 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 320483000893 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 320483000894 GatB domain; Region: GatB_Yqey; smart00845 320483000895 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 320483000896 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 320483000897 NAD binding site [chemical binding]; other site 320483000898 homotetramer interface [polypeptide binding]; other site 320483000899 homodimer interface [polypeptide binding]; other site 320483000900 substrate binding site [chemical binding]; other site 320483000901 active site 320483000902 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 320483000903 DnaA N-terminal domain; Region: DnaA_N; pfam11638 320483000904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483000905 Walker A motif; other site 320483000906 ATP binding site [chemical binding]; other site 320483000907 Walker B motif; other site 320483000908 arginine finger; other site 320483000909 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 320483000910 DnaA box-binding interface [nucleotide binding]; other site 320483000911 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 320483000912 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 320483000913 active site 320483000914 (T/H)XGH motif; other site 320483000915 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 320483000916 active site 320483000917 hydrophilic channel; other site 320483000918 dimerization interface [polypeptide binding]; other site 320483000919 catalytic residues [active] 320483000920 active site lid [active] 320483000921 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320483000922 IHF dimer interface [polypeptide binding]; other site 320483000923 IHF - DNA interface [nucleotide binding]; other site 320483000924 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 320483000925 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 320483000926 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 320483000927 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 320483000928 CoA-binding site [chemical binding]; other site 320483000929 ATP-binding [chemical binding]; other site 320483000930 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 320483000931 ThiC-associated domain; Region: ThiC-associated; pfam13667 320483000932 ThiC family; Region: ThiC; pfam01964 320483000933 Smr domain; Region: Smr; pfam01713 320483000934 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 320483000935 Helix-turn-helix domain; Region: HTH_37; pfam13744 320483000936 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 320483000937 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 320483000938 HIGH motif; other site 320483000939 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320483000940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483000941 active site 320483000942 KMSKS motif; other site 320483000943 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 320483000944 tRNA binding surface [nucleotide binding]; other site 320483000945 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320483000946 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 320483000947 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 320483000948 active site 320483000949 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 320483000950 active site 320483000951 dimer interface [polypeptide binding]; other site 320483000952 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 320483000953 Survival protein SurE; Region: SurE; pfam01975 320483000954 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 320483000955 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 320483000956 NADH dehydrogenase subunit B; Validated; Region: PRK06411 320483000957 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 320483000958 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 320483000959 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320483000960 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320483000961 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 320483000962 transcription antitermination factor NusB; Region: nusB; TIGR01951 320483000963 putative RNA binding site [nucleotide binding]; other site 320483000964 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 320483000965 homopentamer interface [polypeptide binding]; other site 320483000966 active site 320483000967 membrane protein insertase; Provisional; Region: PRK01318 320483000968 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 320483000969 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 320483000970 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 320483000971 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 320483000972 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 320483000973 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 320483000974 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 320483000975 FAD binding pocket [chemical binding]; other site 320483000976 FAD binding motif [chemical binding]; other site 320483000977 phosphate binding motif [ion binding]; other site 320483000978 beta-alpha-beta structure motif; other site 320483000979 NAD binding pocket [chemical binding]; other site 320483000980 Iron coordination center [ion binding]; other site 320483000981 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 320483000982 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 320483000983 active site 320483000984 homodimer interface [polypeptide binding]; other site 320483000985 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 320483000986 elongation factor P; Validated; Region: PRK00529 320483000987 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 320483000988 RNA binding site [nucleotide binding]; other site 320483000989 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 320483000990 RNA binding site [nucleotide binding]; other site 320483000991 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 320483000992 active site 320483000993 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 320483000994 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320483000995 active site 320483000996 response regulator PleD; Reviewed; Region: pleD; PRK09581 320483000997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320483000998 active site 320483000999 phosphorylation site [posttranslational modification] 320483001000 intermolecular recognition site; other site 320483001001 dimerization interface [polypeptide binding]; other site 320483001002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320483001003 active site 320483001004 phosphorylation site [posttranslational modification] 320483001005 intermolecular recognition site; other site 320483001006 dimerization interface [polypeptide binding]; other site 320483001007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320483001008 metal binding site [ion binding]; metal-binding site 320483001009 active site 320483001010 I-site; other site 320483001011 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 320483001012 potential frameshift: common BLAST hit: gi|88607191|ref|YP_505145.1| NAD-glutamate dehydrogenase family protein 320483001013 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 320483001014 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 320483001015 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 320483001016 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 320483001017 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 320483001018 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320483001019 active site 320483001020 HIGH motif; other site 320483001021 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320483001022 KMSKS motif; other site 320483001023 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320483001024 tRNA binding surface [nucleotide binding]; other site 320483001025 anticodon binding site; other site 320483001026 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 320483001027 dimer interface [polypeptide binding]; other site 320483001028 putative radical transfer pathway; other site 320483001029 diiron center [ion binding]; other site 320483001030 tyrosyl radical; other site 320483001031 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320483001032 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320483001033 catalytic residues [active] 320483001034 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 320483001035 Uncharacterized conserved protein [Function unknown]; Region: COG1565 320483001036 DNA primase; Validated; Region: dnaG; PRK05667 320483001037 CHC2 zinc finger; Region: zf-CHC2; cl17510 320483001038 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 320483001039 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 320483001040 active site 320483001041 metal binding site [ion binding]; metal-binding site 320483001042 interdomain interaction site; other site 320483001043 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 320483001044 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320483001045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320483001046 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320483001047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320483001048 DNA binding residues [nucleotide binding] 320483001049 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 320483001050 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 320483001051 FMN binding site [chemical binding]; other site 320483001052 active site 320483001053 catalytic residues [active] 320483001054 substrate binding site [chemical binding]; other site 320483001055 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 320483001056 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 320483001057 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 320483001058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320483001059 dimer interface [polypeptide binding]; other site 320483001060 phosphorylation site [posttranslational modification] 320483001061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483001062 ATP binding site [chemical binding]; other site 320483001063 Mg2+ binding site [ion binding]; other site 320483001064 G-X-G motif; other site 320483001065 Response regulator receiver domain; Region: Response_reg; pfam00072 320483001066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320483001067 active site 320483001068 phosphorylation site [posttranslational modification] 320483001069 intermolecular recognition site; other site 320483001070 dimerization interface [polypeptide binding]; other site 320483001071 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 320483001072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483001073 S-adenosylmethionine binding site [chemical binding]; other site 320483001074 2-methylcitrate dehydratase; Region: prpD; TIGR02330 320483001075 Uncharacterized conserved protein [Function unknown]; Region: COG0062 320483001076 putative carbohydrate kinase; Provisional; Region: PRK10565 320483001077 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 320483001078 putative substrate binding site [chemical binding]; other site 320483001079 putative ATP binding site [chemical binding]; other site 320483001080 DNA topoisomerase I; Validated; Region: PRK06599 320483001081 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 320483001082 active site 320483001083 interdomain interaction site; other site 320483001084 putative metal-binding site [ion binding]; other site 320483001085 nucleotide binding site [chemical binding]; other site 320483001086 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 320483001087 domain I; other site 320483001088 DNA binding groove [nucleotide binding] 320483001089 phosphate binding site [ion binding]; other site 320483001090 domain II; other site 320483001091 domain III; other site 320483001092 nucleotide binding site [chemical binding]; other site 320483001093 catalytic site [active] 320483001094 domain IV; other site 320483001095 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 320483001096 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 320483001097 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 320483001098 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 320483001099 Stringent starvation protein B; Region: SspB; pfam04386 320483001100 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14659 320483001101 prolyl-tRNA synthetase; Provisional; Region: PRK12325 320483001102 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 320483001103 dimer interface [polypeptide binding]; other site 320483001104 motif 1; other site 320483001105 active site 320483001106 motif 2; other site 320483001107 motif 3; other site 320483001108 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 320483001109 anticodon binding site; other site 320483001110 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 320483001111 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 320483001112 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 320483001113 active site 320483001114 (T/H)XGH motif; other site 320483001115 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 320483001116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320483001117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320483001118 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320483001119 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 320483001120 dimer interface [polypeptide binding]; other site 320483001121 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320483001122 catalytic triad [active] 320483001123 peroxidatic and resolving cysteines [active] 320483001124 aspartate aminotransferase; Provisional; Region: PRK05764 320483001125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320483001126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320483001127 homodimer interface [polypeptide binding]; other site 320483001128 catalytic residue [active] 320483001129 SurA N-terminal domain; Region: SurA_N_3; cl07813 320483001130 periplasmic folding chaperone; Provisional; Region: PRK10788 320483001131 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 320483001132 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320483001133 Glycoprotease family; Region: Peptidase_M22; pfam00814 320483001134 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 320483001135 potential protein location (Conserved hypothetical protein [Anaplasma marginale str. Florida]) that overlaps RNA (tRNA-R) 320483001136 rod shape-determining protein MreC; Provisional; Region: PRK13922 320483001137 rod shape-determining protein MreC; Region: MreC; pfam04085 320483001138 rod shape-determining protein MreB; Provisional; Region: PRK13927 320483001139 MreB and similar proteins; Region: MreB_like; cd10225 320483001140 nucleotide binding site [chemical binding]; other site 320483001141 Mg binding site [ion binding]; other site 320483001142 putative protofilament interaction site [polypeptide binding]; other site 320483001143 RodZ interaction site [polypeptide binding]; other site 320483001144 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 320483001145 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 320483001146 RNA binding site [nucleotide binding]; other site 320483001147 active site 320483001148 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 320483001149 16S/18S rRNA binding site [nucleotide binding]; other site 320483001150 S13e-L30e interaction site [polypeptide binding]; other site 320483001151 25S rRNA binding site [nucleotide binding]; other site 320483001152 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 320483001153 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 320483001154 oligomer interface [polypeptide binding]; other site 320483001155 RNA binding site [nucleotide binding]; other site 320483001156 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 320483001157 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 320483001158 RNase E interface [polypeptide binding]; other site 320483001159 trimer interface [polypeptide binding]; other site 320483001160 active site 320483001161 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 320483001162 putative nucleic acid binding region [nucleotide binding]; other site 320483001163 G-X-X-G motif; other site 320483001164 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 320483001165 RNA binding site [nucleotide binding]; other site 320483001166 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 320483001167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483001168 S-adenosylmethionine binding site [chemical binding]; other site 320483001169 GTP-binding protein LepA; Provisional; Region: PRK05433 320483001170 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 320483001171 G1 box; other site 320483001172 putative GEF interaction site [polypeptide binding]; other site 320483001173 GTP/Mg2+ binding site [chemical binding]; other site 320483001174 Switch I region; other site 320483001175 G2 box; other site 320483001176 G3 box; other site 320483001177 Switch II region; other site 320483001178 G4 box; other site 320483001179 G5 box; other site 320483001180 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 320483001181 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 320483001182 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 320483001183 Major surface protein 1a (MSP1a); Region: MSP1a; pfam11670 320483001184 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 320483001185 thiamine monophosphate kinase; Provisional; Region: PRK05731 320483001186 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 320483001187 ATP binding site [chemical binding]; other site 320483001188 dimerization interface [polypeptide binding]; other site 320483001189 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 320483001190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320483001191 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 320483001192 inhibitor-cofactor binding pocket; inhibition site 320483001193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320483001194 catalytic residue [active] 320483001195 Protein of unknown function (DUF721); Region: DUF721; pfam05258 320483001196 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 320483001197 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 320483001198 triosephosphate isomerase; Provisional; Region: PRK14565 320483001199 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 320483001200 substrate binding site [chemical binding]; other site 320483001201 dimer interface [polypeptide binding]; other site 320483001202 catalytic triad [active] 320483001203 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 320483001204 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 320483001205 UGMP family protein; Validated; Region: PRK09604 320483001206 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320483001207 RDD family; Region: RDD; pfam06271 320483001208 Dihydroneopterin aldolase; Region: FolB; smart00905 320483001209 active site 320483001210 malate dehydrogenase; Reviewed; Region: PRK06223 320483001211 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 320483001212 NAD(P) binding site [chemical binding]; other site 320483001213 dimer interface [polypeptide binding]; other site 320483001214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320483001215 substrate binding site [chemical binding]; other site 320483001216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320483001217 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 320483001218 G4 box; other site 320483001219 G5 box; other site 320483001220 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 320483001221 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 320483001222 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 320483001223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483001224 S-adenosylmethionine binding site [chemical binding]; other site 320483001225 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 320483001226 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 320483001227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 320483001228 Terminase-like family; Region: Terminase_6; pfam03237 320483001229 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 320483001230 Phage major tail protein 2; Region: Phage_tail_2; cl11463 320483001231 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 320483001232 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 320483001233 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 320483001234 Proline dehydrogenase; Region: Pro_dh; pfam01619 320483001235 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 320483001236 Glutamate binding site [chemical binding]; other site 320483001237 NAD binding site [chemical binding]; other site 320483001238 catalytic residues [active] 320483001239 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 320483001240 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320483001241 homotetramer interface [polypeptide binding]; other site 320483001242 NAD(P) binding site [chemical binding]; other site 320483001243 homodimer interface [polypeptide binding]; other site 320483001244 active site 320483001245 Proline dehydrogenase; Region: Pro_dh; cl03282 320483001246 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 320483001247 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 320483001248 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 320483001249 putative catalytic site [active] 320483001250 putative phosphate binding site [ion binding]; other site 320483001251 active site 320483001252 metal binding site A [ion binding]; metal-binding site 320483001253 DNA binding site [nucleotide binding] 320483001254 putative AP binding site [nucleotide binding]; other site 320483001255 putative metal binding site B [ion binding]; other site 320483001256 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 320483001257 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 320483001258 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 320483001259 enolase; Provisional; Region: eno; PRK00077 320483001260 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 320483001261 dimer interface [polypeptide binding]; other site 320483001262 metal binding site [ion binding]; metal-binding site 320483001263 substrate binding pocket [chemical binding]; other site 320483001264 GTPase CgtA; Reviewed; Region: obgE; PRK12299 320483001265 GTP1/OBG; Region: GTP1_OBG; pfam01018 320483001266 Obg GTPase; Region: Obg; cd01898 320483001267 G1 box; other site 320483001268 GTP/Mg2+ binding site [chemical binding]; other site 320483001269 Switch I region; other site 320483001270 G2 box; other site 320483001271 G3 box; other site 320483001272 Switch II region; other site 320483001273 G4 box; other site 320483001274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320483001275 Cell division protein FtsL; Region: FtsL; cl11433 320483001276 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 320483001277 MraW methylase family; Region: Methyltransf_5; cl17771 320483001278 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 320483001279 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 320483001280 large tegument protein UL36; Provisional; Region: PHA03247 320483001281 large tegument protein UL36; Provisional; Region: PHA03247 320483001282 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 320483001283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320483001284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320483001285 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 320483001286 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 320483001287 GTP cyclohydrolase I; Provisional; Region: PLN03044 320483001288 active site 320483001289 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 320483001290 core domain interface [polypeptide binding]; other site 320483001291 delta subunit interface [polypeptide binding]; other site 320483001292 epsilon subunit interface [polypeptide binding]; other site 320483001293 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 320483001294 NADH dehydrogenase subunit D; Validated; Region: PRK06075 320483001295 NADH dehydrogenase subunit E; Validated; Region: PRK07539 320483001296 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 320483001297 putative dimer interface [polypeptide binding]; other site 320483001298 [2Fe-2S] cluster binding site [ion binding]; other site 320483001299 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 320483001300 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 320483001301 active site 320483001302 catalytic site [active] 320483001303 substrate binding site [chemical binding]; other site 320483001304 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 320483001305 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320483001306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483001307 Walker A motif; other site 320483001308 ATP binding site [chemical binding]; other site 320483001309 Walker B motif; other site 320483001310 arginine finger; other site 320483001311 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 320483001312 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 320483001313 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 320483001314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320483001315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320483001316 DNA binding residues [nucleotide binding] 320483001317 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 320483001318 30S subunit binding site; other site 320483001319 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001320 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 320483001321 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001322 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001323 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320483001324 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 320483001325 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 320483001326 NADH dehydrogenase subunit G; Validated; Region: PRK09130 320483001327 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320483001328 catalytic loop [active] 320483001329 iron binding site [ion binding]; other site 320483001330 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 320483001331 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 320483001332 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 320483001333 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 320483001334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320483001335 Mg2+ binding site [ion binding]; other site 320483001336 G-X-G motif; other site 320483001337 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 320483001338 anchoring element; other site 320483001339 dimer interface [polypeptide binding]; other site 320483001340 ATP binding site [chemical binding]; other site 320483001341 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 320483001342 active site 320483001343 putative metal-binding site [ion binding]; other site 320483001344 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 320483001345 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 320483001346 Flavoprotein; Region: Flavoprotein; pfam02441 320483001347 Cytochrome C biogenesis protein; Region: CcmH; cl01179 320483001348 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 320483001349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320483001350 catalytic loop [active] 320483001351 iron binding site [ion binding]; other site 320483001352 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 320483001353 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 320483001354 nucleotide binding site [chemical binding]; other site 320483001355 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320483001356 SBD interface [polypeptide binding]; other site 320483001357 co-chaperone HscB; Provisional; Region: hscB; PRK05014 320483001358 DnaJ domain; Region: DnaJ; pfam00226 320483001359 HSP70 interaction site [polypeptide binding]; other site 320483001360 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 320483001361 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 320483001362 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 320483001363 trimerization site [polypeptide binding]; other site 320483001364 active site 320483001365 cysteine desulfurase; Provisional; Region: PRK14012 320483001366 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 320483001367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320483001368 catalytic residue [active] 320483001369 Predicted transcriptional regulator [Transcription]; Region: COG1959 320483001370 Transcriptional regulator; Region: Rrf2; cl17282 320483001371 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 320483001372 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 320483001373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320483001374 catalytic residue [active] 320483001375 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 320483001376 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 320483001377 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483001378 active site 320483001379 nucleotide binding site [chemical binding]; other site 320483001380 HIGH motif; other site 320483001381 KMSKS motif; other site 320483001382 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 320483001383 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 320483001384 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 320483001385 dimerization interface 3.5A [polypeptide binding]; other site 320483001386 active site 320483001387 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 320483001388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320483001389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320483001390 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 320483001391 active site 320483001392 intersubunit interactions; other site 320483001393 catalytic residue [active] 320483001394 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 320483001395 gamma subunit interface [polypeptide binding]; other site 320483001396 epsilon subunit interface [polypeptide binding]; other site 320483001397 LBP interface [polypeptide binding]; other site 320483001398 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 320483001399 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320483001400 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 320483001401 alpha subunit interaction interface [polypeptide binding]; other site 320483001402 Walker A motif; other site 320483001403 ATP binding site [chemical binding]; other site 320483001404 Walker B motif; other site 320483001405 inhibitor binding site; inhibition site 320483001406 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320483001407 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 320483001408 MgtE intracellular N domain; Region: MgtE_N; smart00924 320483001409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 320483001410 Divalent cation transporter; Region: MgtE; cl00786 320483001411 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 320483001412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483001413 S-adenosylmethionine binding site [chemical binding]; other site 320483001414 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 320483001415 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 320483001416 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 320483001417 active site 320483001418 HIGH motif; other site 320483001419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483001420 KMSK motif region; other site 320483001421 tRNA binding surface [nucleotide binding]; other site 320483001422 DALR anticodon binding domain; Region: DALR_1; smart00836 320483001423 anticodon binding site; other site 320483001424 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 320483001425 Recombination protein O C terminal; Region: RecO_C; pfam02565 320483001426 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 320483001427 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 320483001428 HIGH motif; other site 320483001429 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 320483001430 active site 320483001431 KMSKS motif; other site 320483001432 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 320483001433 tRNA binding surface [nucleotide binding]; other site 320483001434 anticodon binding site; other site 320483001435 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 320483001436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320483001437 catalytic triad [active] 320483001438 RNA methyltransferase, RsmE family; Region: TIGR00046 320483001439 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 320483001440 peptide chain release factor 2; Validated; Region: prfB; PRK00578 320483001441 PCRF domain; Region: PCRF; pfam03462 320483001442 RF-1 domain; Region: RF-1; pfam00472 320483001443 hypothetical protein; Validated; Region: PRK00110 320483001444 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 320483001445 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 320483001446 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 320483001447 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 320483001448 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 320483001449 domain interfaces; other site 320483001450 active site 320483001451 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 320483001452 FAD binding domain; Region: FAD_binding_4; pfam01565 320483001453 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 320483001454 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 320483001455 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001456 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001457 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001458 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 320483001459 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 320483001460 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320483001461 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320483001462 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001463 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483001464 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320483001465 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 320483001466 4Fe-4S binding domain; Region: Fer4; cl02805 320483001467 4Fe-4S binding domain; Region: Fer4; pfam00037 320483001468 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 320483001469 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320483001470 Catalytic site [active] 320483001471 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320483001472 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 320483001473 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483001474 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483001475 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 320483001476 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 320483001477 G1 box; other site 320483001478 putative GEF interaction site [polypeptide binding]; other site 320483001479 GTP/Mg2+ binding site [chemical binding]; other site 320483001480 Switch I region; other site 320483001481 G2 box; other site 320483001482 G3 box; other site 320483001483 Switch II region; other site 320483001484 G4 box; other site 320483001485 G5 box; other site 320483001486 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 320483001487 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 320483001488 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 320483001489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483001490 Walker A motif; other site 320483001491 ATP binding site [chemical binding]; other site 320483001492 Walker B motif; other site 320483001493 arginine finger; other site 320483001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483001495 Walker A motif; other site 320483001496 ATP binding site [chemical binding]; other site 320483001497 Walker B motif; other site 320483001498 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320483001499 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 320483001500 Ribosome-binding factor A; Region: RBFA; pfam02033 320483001501 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 320483001502 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 320483001503 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 320483001504 G1 box; other site 320483001505 putative GEF interaction site [polypeptide binding]; other site 320483001506 GTP/Mg2+ binding site [chemical binding]; other site 320483001507 Switch I region; other site 320483001508 G2 box; other site 320483001509 G3 box; other site 320483001510 Switch II region; other site 320483001511 G4 box; other site 320483001512 G5 box; other site 320483001513 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 320483001514 Translation-initiation factor 2; Region: IF-2; pfam11987 320483001515 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 320483001516 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 320483001517 NusA N-terminal domain; Region: NusA_N; pfam08529 320483001518 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 320483001519 RNA binding site [nucleotide binding]; other site 320483001520 homodimer interface [polypeptide binding]; other site 320483001521 NusA-like KH domain; Region: KH_5; pfam13184 320483001522 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 320483001523 G-X-X-G motif; other site 320483001524 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 320483001525 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 320483001526 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 320483001527 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 320483001528 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320483001529 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320483001530 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 320483001531 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 320483001532 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 320483001533 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 320483001534 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 320483001535 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483001536 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 320483001537 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483001538 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 320483001539 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 320483001540 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483001541 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 320483001542 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 320483001543 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 320483001544 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 320483001545 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 320483001546 SLBB domain; Region: SLBB; pfam10531 320483001547 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 320483001548 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 320483001549 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 320483001550 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 320483001551 VirB8 protein; Region: VirB8; cl01500 320483001552 RmuC family; Region: RmuC; pfam02646 320483001553 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 320483001554 seryl-tRNA synthetase; Provisional; Region: PRK05431 320483001555 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 320483001556 dimer interface [polypeptide binding]; other site 320483001557 active site 320483001558 motif 1; other site 320483001559 motif 2; other site 320483001560 motif 3; other site 320483001561 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 320483001562 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 320483001563 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 320483001564 feedback inhibition sensing region; other site 320483001565 homohexameric interface [polypeptide binding]; other site 320483001566 nucleotide binding site [chemical binding]; other site 320483001567 N-acetyl-L-glutamate binding site [chemical binding]; other site 320483001568 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 320483001569 G1 box; other site 320483001570 GTP/Mg2+ binding site [chemical binding]; other site 320483001571 Switch I region; other site 320483001572 G2 box; other site 320483001573 G3 box; other site 320483001574 Switch II region; other site 320483001575 G4 box; other site 320483001576 G5 box; other site 320483001577 peptide chain release factor 1; Validated; Region: prfA; PRK00591 320483001578 This domain is found in peptide chain release factors; Region: PCRF; smart00937 320483001579 RF-1 domain; Region: RF-1; pfam00472 320483001580 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 320483001581 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 320483001582 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 320483001583 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 320483001584 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 320483001585 DNA binding site [nucleotide binding] 320483001586 catalytic residue [active] 320483001587 H2TH interface [polypeptide binding]; other site 320483001588 putative catalytic residues [active] 320483001589 turnover-facilitating residue; other site 320483001590 intercalation triad [nucleotide binding]; other site 320483001591 8OG recognition residue [nucleotide binding]; other site 320483001592 putative reading head residues; other site 320483001593 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 320483001594 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320483001595 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 320483001596 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320483001597 active site 320483001598 HIGH motif; other site 320483001599 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320483001600 active site 320483001601 KMSKS motif; other site 320483001602 Protein of unknown function (DUF2861); Region: DUF2861; pfam11060 320483001603 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 320483001604 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 320483001605 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 320483001606 Qi binding site; other site 320483001607 intrachain domain interface; other site 320483001608 interchain domain interface [polypeptide binding]; other site 320483001609 cytochrome b; Provisional; Region: CYTB; MTH00156 320483001610 heme bH binding site [chemical binding]; other site 320483001611 heme bL binding site [chemical binding]; other site 320483001612 Qo binding site; other site 320483001613 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 320483001614 interchain domain interface [polypeptide binding]; other site 320483001615 intrachain domain interface; other site 320483001616 Qi binding site; other site 320483001617 Qo binding site; other site 320483001618 potential frameshift: common BLAST hit: gi|56416900|ref|YP_153974.1| cytochrome B6-F complex iron-sulfur subunit 320483001619 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 320483001620 [2Fe-2S] cluster binding site [ion binding]; other site 320483001621 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 320483001622 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320483001623 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 320483001624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320483001625 ABC-ATPase subunit interface; other site 320483001626 dimer interface [polypeptide binding]; other site 320483001627 putative PBP binding regions; other site 320483001628 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 320483001629 elongation factor Ts; Provisional; Region: tsf; PRK09377 320483001630 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 320483001631 Elongation factor TS; Region: EF_TS; pfam00889 320483001632 Elongation factor TS; Region: EF_TS; pfam00889 320483001633 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 320483001634 rRNA interaction site [nucleotide binding]; other site 320483001635 S8 interaction site; other site 320483001636 putative laminin-1 binding site; other site 320483001637 Maf-like protein; Region: Maf; pfam02545 320483001638 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 320483001639 active site 320483001640 dimer interface [polypeptide binding]; other site 320483001641 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 320483001642 rRNA binding site [nucleotide binding]; other site 320483001643 predicted 30S ribosome binding site; other site 320483001644 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320483001645 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 320483001646 HlyD family secretion protein; Region: HlyD_3; pfam13437 320483001647 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 320483001648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320483001649 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320483001650 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 320483001651 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 320483001652 PQQ-like domain; Region: PQQ_2; pfam13360 320483001653 Trp docking motif [polypeptide binding]; other site 320483001654 active site 320483001655 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 320483001656 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 320483001657 G1 box; other site 320483001658 GTP/Mg2+ binding site [chemical binding]; other site 320483001659 Switch I region; other site 320483001660 G2 box; other site 320483001661 Switch II region; other site 320483001662 G3 box; other site 320483001663 G4 box; other site 320483001664 G5 box; other site 320483001665 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 320483001666 G1 box; other site 320483001667 GTP/Mg2+ binding site [chemical binding]; other site 320483001668 Switch I region; other site 320483001669 G2 box; other site 320483001670 G3 box; other site 320483001671 Switch II region; other site 320483001672 G4 box; other site 320483001673 G5 box; other site 320483001674 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 320483001675 phosphoglyceromutase; Provisional; Region: PRK05434 320483001676 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 320483001677 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 320483001678 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 320483001679 catalytic site [active] 320483001680 subunit interface [polypeptide binding]; other site 320483001681 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 320483001682 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 320483001683 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320483001684 trimer interface [polypeptide binding]; other site 320483001685 active site 320483001686 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 320483001687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320483001688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320483001689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320483001690 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 320483001691 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 320483001692 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 320483001693 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 320483001694 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 320483001695 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 320483001696 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 320483001697 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 320483001698 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 320483001699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483001700 Walker A/P-loop; other site 320483001701 ATP binding site [chemical binding]; other site 320483001702 Q-loop/lid; other site 320483001703 type IV secretion system protein VirB3; Provisional; Region: PRK13899 320483001704 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 320483001705 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 320483001706 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 320483001707 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 320483001708 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 320483001709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320483001710 dimer interface [polypeptide binding]; other site 320483001711 conserved gate region; other site 320483001712 putative PBP binding loops; other site 320483001713 ABC-ATPase subunit interface; other site 320483001714 lipoyl synthase; Provisional; Region: PRK05481 320483001715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320483001716 FeS/SAM binding site; other site 320483001717 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 320483001718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320483001719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320483001720 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320483001721 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320483001722 carboxyltransferase (CT) interaction site; other site 320483001723 biotinylation site [posttranslational modification]; other site 320483001724 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 320483001725 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320483001726 RNA binding surface [nucleotide binding]; other site 320483001727 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320483001728 active site 320483001729 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 320483001730 primosome assembly protein PriA; Validated; Region: PRK05580 320483001731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320483001732 ATP binding site [chemical binding]; other site 320483001733 putative Mg++ binding site [ion binding]; other site 320483001734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320483001735 nucleotide binding region [chemical binding]; other site 320483001736 ATP-binding site [chemical binding]; other site 320483001737 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 320483001738 conserved cys residue [active] 320483001739 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 320483001740 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 320483001741 active site 320483001742 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 320483001743 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 320483001744 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 320483001745 active site 320483001746 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 320483001747 catalytic motif [active] 320483001748 Catalytic residue [active] 320483001749 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 320483001750 active site 320483001751 catalytic site [active] 320483001752 substrate binding site [chemical binding]; other site 320483001753 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 320483001754 GTPase Era; Reviewed; Region: era; PRK00089 320483001755 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 320483001756 G1 box; other site 320483001757 GTP/Mg2+ binding site [chemical binding]; other site 320483001758 Switch I region; other site 320483001759 G2 box; other site 320483001760 Switch II region; other site 320483001761 G3 box; other site 320483001762 G4 box; other site 320483001763 G5 box; other site 320483001764 KH domain; Region: KH_2; pfam07650 320483001765 signal recognition particle protein; Provisional; Region: PRK10867 320483001766 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 320483001767 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320483001768 P loop; other site 320483001769 GTP binding site [chemical binding]; other site 320483001770 Signal peptide binding domain; Region: SRP_SPB; pfam02978 320483001771 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12664 320483001772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320483001773 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 320483001774 putative coenzyme Q binding site [chemical binding]; other site 320483001775 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 320483001776 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320483001777 nucleotide binding site [chemical binding]; other site 320483001778 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 320483001779 RNA binding site [nucleotide binding]; other site 320483001780 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 320483001781 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 320483001782 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 320483001783 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 320483001784 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 320483001785 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 320483001786 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 320483001787 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12670 320483001788 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12603 320483001789 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 320483001790 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 320483001791 TPP-binding site [chemical binding]; other site 320483001792 dimer interface [polypeptide binding]; other site 320483001793 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320483001794 PYR/PP interface [polypeptide binding]; other site 320483001795 dimer interface [polypeptide binding]; other site 320483001796 TPP binding site [chemical binding]; other site 320483001797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320483001798 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 320483001799 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320483001800 Zn binding site [ion binding]; other site 320483001801 putative outer membrane lipoprotein; Provisional; Region: PRK09967 320483001802 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320483001803 ligand binding site [chemical binding]; other site 320483001804 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 320483001805 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 320483001806 GDP-binding site [chemical binding]; other site 320483001807 ACT binding site; other site 320483001808 IMP binding site; other site 320483001809 GTPase CgtA; Reviewed; Region: obgE; PRK12299 320483001810 GTP1/OBG; Region: GTP1_OBG; pfam01018 320483001811 Obg GTPase; Region: Obg; cd01898 320483001812 G1 box; other site 320483001813 GTP/Mg2+ binding site [chemical binding]; other site 320483001814 Switch I region; other site 320483001815 G2 box; other site 320483001816 G3 box; other site 320483001817 Switch II region; other site 320483001818 G4 box; other site 320483001819 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 320483001820 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 320483001821 Class I ribonucleotide reductase; Region: RNR_I; cd01679 320483001822 active site 320483001823 dimer interface [polypeptide binding]; other site 320483001824 catalytic residues [active] 320483001825 effector binding site; other site 320483001826 R2 peptide binding site; other site 320483001827 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320483001828 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320483001829 substrate binding pocket [chemical binding]; other site 320483001830 chain length determination region; other site 320483001831 substrate-Mg2+ binding site; other site 320483001832 catalytic residues [active] 320483001833 aspartate-rich region 1; other site 320483001834 active site lid residues [active] 320483001835 aspartate-rich region 2; other site 320483001836 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320483001837 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 320483001838 replicative DNA helicase; Provisional; Region: PRK09165 320483001839 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 320483001840 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 320483001841 Walker A motif; other site 320483001842 ATP binding site [chemical binding]; other site 320483001843 Walker B motif; other site 320483001844 DNA binding loops [nucleotide binding] 320483001845 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 320483001846 nucleoside/Zn binding site; other site 320483001847 dimer interface [polypeptide binding]; other site 320483001848 catalytic motif [active] 320483001849 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320483001850 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320483001851 dimer interface [polypeptide binding]; other site 320483001852 active site 320483001853 CoA binding pocket [chemical binding]; other site 320483001854 putative phosphate acyltransferase; Provisional; Region: PRK05331 320483001855 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 320483001856 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 320483001857 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 320483001858 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14244 320483001859 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 320483001860 Walker A/P-loop; other site 320483001861 ATP binding site [chemical binding]; other site 320483001862 Q-loop/lid; other site 320483001863 ABC transporter signature motif; other site 320483001864 Walker B; other site 320483001865 D-loop; other site 320483001866 H-loop/switch region; other site 320483001867 dihydrodipicolinate reductase; Provisional; Region: PRK00048 320483001868 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 320483001869 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 320483001870 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 320483001871 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 320483001872 UbiA prenyltransferase family; Region: UbiA; pfam01040 320483001873 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 320483001874 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 320483001875 seryl-tRNA synthetase; Provisional; Region: PRK05431 320483001876 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 320483001877 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 320483001878 Ribonuclease P; Region: Ribonuclease_P; pfam00825 320483001879 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 320483001880 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 320483001881 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 320483001882 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 320483001883 Competence protein; Region: Competence; pfam03772 320483001884 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 320483001885 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 320483001886 putative tRNA-binding site [nucleotide binding]; other site 320483001887 B3/4 domain; Region: B3_4; pfam03483 320483001888 tRNA synthetase B5 domain; Region: B5; smart00874 320483001889 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 320483001890 dimer interface [polypeptide binding]; other site 320483001891 motif 1; other site 320483001892 motif 3; other site 320483001893 motif 2; other site 320483001894 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 320483001895 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 320483001896 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 320483001897 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 320483001898 alphaNTD - beta interaction site [polypeptide binding]; other site 320483001899 alphaNTD homodimer interface [polypeptide binding]; other site 320483001900 alphaNTD - beta' interaction site [polypeptide binding]; other site 320483001901 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 320483001902 30S ribosomal protein S11; Validated; Region: PRK05309 320483001903 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 320483001904 30S ribosomal protein S13; Region: bact_S13; TIGR03631 320483001905 adenylate kinase; Region: adk; TIGR01351 320483001906 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 320483001907 AMP-binding site [chemical binding]; other site 320483001908 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 320483001909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 320483001910 SecY translocase; Region: SecY; pfam00344 320483001911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 320483001912 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 320483001913 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 320483001914 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 320483001915 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 320483001916 5S rRNA interface [nucleotide binding]; other site 320483001917 23S rRNA interface [nucleotide binding]; other site 320483001918 L5 interface [polypeptide binding]; other site 320483001919 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 320483001920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320483001921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320483001922 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 320483001923 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 320483001924 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 320483001925 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 320483001926 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 320483001927 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 320483001928 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 320483001929 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 320483001930 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 320483001931 putative translocon interaction site; other site 320483001932 23S rRNA interface [nucleotide binding]; other site 320483001933 signal recognition particle (SRP54) interaction site; other site 320483001934 L23 interface [polypeptide binding]; other site 320483001935 trigger factor interaction site; other site 320483001936 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 320483001937 23S rRNA interface [nucleotide binding]; other site 320483001938 5S rRNA interface [nucleotide binding]; other site 320483001939 putative antibiotic binding site [chemical binding]; other site 320483001940 L25 interface [polypeptide binding]; other site 320483001941 L27 interface [polypeptide binding]; other site 320483001942 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 320483001943 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 320483001944 G-X-X-G motif; other site 320483001945 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 320483001946 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 320483001947 putative translocon binding site; other site 320483001948 protein-rRNA interface [nucleotide binding]; other site 320483001949 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 320483001950 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 320483001951 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 320483001952 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 320483001953 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 320483001954 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 320483001955 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 320483001956 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 320483001957 elongation factor Tu; Reviewed; Region: PRK00049 320483001958 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320483001959 G1 box; other site 320483001960 GEF interaction site [polypeptide binding]; other site 320483001961 GTP/Mg2+ binding site [chemical binding]; other site 320483001962 Switch I region; other site 320483001963 G2 box; other site 320483001964 G3 box; other site 320483001965 Switch II region; other site 320483001966 G4 box; other site 320483001967 G5 box; other site 320483001968 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320483001969 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320483001970 Antibiotic Binding Site [chemical binding]; other site 320483001971 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 320483001972 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 320483001973 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 320483001974 cytidylate kinase; Provisional; Region: cmk; PRK00023 320483001975 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 320483001976 CMP-binding site; other site 320483001977 The sites determining sugar specificity; other site 320483001978 ribosomal protein S1; Region: rpsA; TIGR00717 320483001979 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 320483001980 RNA binding site [nucleotide binding]; other site 320483001981 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 320483001982 RNA binding site [nucleotide binding]; other site 320483001983 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 320483001984 RNA binding site [nucleotide binding]; other site 320483001985 S1 RNA binding domain; Region: S1; pfam00575 320483001986 RNA binding site [nucleotide binding]; other site 320483001987 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 320483001988 RNA binding site [nucleotide binding]; other site 320483001989 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 320483001990 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 320483001991 tandem repeat interface [polypeptide binding]; other site 320483001992 oligomer interface [polypeptide binding]; other site 320483001993 active site residues [active] 320483001994 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 320483001995 Cell division protein ZapA; Region: ZapA; pfam05164 320483001996 ferrochelatase; Reviewed; Region: hemH; PRK00035 320483001997 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 320483001998 C-terminal domain interface [polypeptide binding]; other site 320483001999 active site 320483002000 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 320483002001 active site 320483002002 N-terminal domain interface [polypeptide binding]; other site 320483002003 Predicted ATPase [General function prediction only]; Region: COG1485 320483002004 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 320483002005 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 320483002006 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 320483002007 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320483002008 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 320483002009 Part of AAA domain; Region: AAA_19; pfam13245 320483002010 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 320483002011 Family description; Region: UvrD_C_2; pfam13538 320483002012 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 320483002013 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320483002014 NADP binding site [chemical binding]; other site 320483002015 dimer interface [polypeptide binding]; other site 320483002016 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 320483002017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320483002018 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 320483002019 Walker A/P-loop; other site 320483002020 ATP binding site [chemical binding]; other site 320483002021 Q-loop/lid; other site 320483002022 ABC transporter signature motif; other site 320483002023 Walker B; other site 320483002024 D-loop; other site 320483002025 H-loop/switch region; other site 320483002026 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 320483002027 dihydropteroate synthase; Region: DHPS; TIGR01496 320483002028 substrate binding pocket [chemical binding]; other site 320483002029 dimer interface [polypeptide binding]; other site 320483002030 inhibitor binding site; inhibition site 320483002031 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 320483002032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320483002033 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320483002034 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 320483002035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320483002036 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320483002037 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 320483002038 IMP binding site; other site 320483002039 dimer interface [polypeptide binding]; other site 320483002040 interdomain contacts; other site 320483002041 partial ornithine binding site; other site 320483002042 fumarate hydratase; Reviewed; Region: fumC; PRK00485 320483002043 Class II fumarases; Region: Fumarase_classII; cd01362 320483002044 active site 320483002045 tetramer interface [polypeptide binding]; other site 320483002046 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 320483002047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320483002048 dihydroorotase; Validated; Region: pyrC; PRK09357 320483002049 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 320483002050 active site 320483002051 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 320483002052 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 320483002053 active site 320483002054 substrate binding site [chemical binding]; other site 320483002055 metal binding site [ion binding]; metal-binding site 320483002056 lipoate-protein ligase B; Provisional; Region: PRK14341 320483002057 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 320483002058 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 320483002059 MPN+ (JAMM) motif; other site 320483002060 Zinc-binding site [ion binding]; other site 320483002061 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320483002062 oligomerisation interface [polypeptide binding]; other site 320483002063 mobile loop; other site 320483002064 roof hairpin; other site 320483002065 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 320483002066 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 320483002067 ring oligomerisation interface [polypeptide binding]; other site 320483002068 ATP/Mg binding site [chemical binding]; other site 320483002069 stacking interactions; other site 320483002070 hinge regions; other site 320483002071 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 320483002072 classical (c) SDRs; Region: SDR_c; cd05233 320483002073 NAD(P) binding site [chemical binding]; other site 320483002074 active site 320483002075 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 320483002076 Clp amino terminal domain; Region: Clp_N; pfam02861 320483002077 Clp amino terminal domain; Region: Clp_N; pfam02861 320483002078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483002079 Walker A motif; other site 320483002080 ATP binding site [chemical binding]; other site 320483002081 Walker B motif; other site 320483002082 arginine finger; other site 320483002083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483002084 Walker A motif; other site 320483002085 ATP binding site [chemical binding]; other site 320483002086 Walker B motif; other site 320483002087 arginine finger; other site 320483002088 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320483002089 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 320483002090 multifunctional aminopeptidase A; Provisional; Region: PRK00913 320483002091 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 320483002092 interface (dimer of trimers) [polypeptide binding]; other site 320483002093 Substrate-binding/catalytic site; other site 320483002094 Zn-binding sites [ion binding]; other site 320483002095 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 320483002096 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 320483002097 active site 320483002098 substrate binding site [chemical binding]; other site 320483002099 cosubstrate binding site; other site 320483002100 catalytic site [active] 320483002101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 320483002102 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 320483002103 putative active site [active] 320483002104 catalytic triad [active] 320483002105 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 320483002106 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 320483002107 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 320483002108 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 320483002109 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 320483002110 putative active site [active] 320483002111 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 320483002112 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320483002113 E3 interaction surface; other site 320483002114 lipoyl attachment site [posttranslational modification]; other site 320483002115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 320483002116 biotin synthase; Region: bioB; TIGR00433 320483002117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320483002118 FeS/SAM binding site; other site 320483002119 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 320483002120 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 320483002121 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 320483002122 dimerization interface [polypeptide binding]; other site 320483002123 ATP binding site [chemical binding]; other site 320483002124 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 320483002125 dimerization interface [polypeptide binding]; other site 320483002126 ATP binding site [chemical binding]; other site 320483002127 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 320483002128 catalytic center binding site [active] 320483002129 ATP binding site [chemical binding]; other site 320483002130 Peptidase family M48; Region: Peptidase_M48; cl12018 320483002131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320483002132 binding surface 320483002133 TPR motif; other site 320483002134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320483002135 TPR motif; other site 320483002136 binding surface 320483002137 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 320483002138 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 320483002139 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 320483002140 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 320483002141 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 320483002142 dimerization interface [polypeptide binding]; other site 320483002143 putative ATP binding site [chemical binding]; other site 320483002144 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 320483002145 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320483002146 active site 320483002147 DNA binding site [nucleotide binding] 320483002148 Int/Topo IB signature motif; other site 320483002149 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 320483002150 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14620 320483002151 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 320483002152 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002153 transcription termination factor Rho; Provisional; Region: rho; PRK09376 320483002154 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 320483002155 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 320483002156 RNA binding site [nucleotide binding]; other site 320483002157 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 320483002158 multimer interface [polypeptide binding]; other site 320483002159 Walker A motif; other site 320483002160 ATP binding site [chemical binding]; other site 320483002161 Walker B motif; other site 320483002162 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 320483002163 active site 320483002164 HslU subunit interaction site [polypeptide binding]; other site 320483002165 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 320483002166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483002167 Walker A motif; other site 320483002168 ATP binding site [chemical binding]; other site 320483002169 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 320483002170 Walker B motif; other site 320483002171 arginine finger; other site 320483002172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320483002173 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 320483002174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483002175 S-adenosylmethionine binding site [chemical binding]; other site 320483002176 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 320483002177 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 320483002178 active site 320483002179 HIGH motif; other site 320483002180 KMSKS motif; other site 320483002181 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 320483002182 tRNA binding surface [nucleotide binding]; other site 320483002183 anticodon binding site; other site 320483002184 aspartate kinase; Reviewed; Region: PRK06635 320483002185 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 320483002186 putative nucleotide binding site [chemical binding]; other site 320483002187 putative catalytic residues [active] 320483002188 putative Mg ion binding site [ion binding]; other site 320483002189 putative aspartate binding site [chemical binding]; other site 320483002190 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 320483002191 putative allosteric regulatory site; other site 320483002192 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 320483002193 putative allosteric regulatory residue; other site 320483002194 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 320483002195 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117 320483002196 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320483002197 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320483002198 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 320483002199 Subunit I/III interface [polypeptide binding]; other site 320483002200 D-pathway; other site 320483002201 Subunit I/VIIc interface [polypeptide binding]; other site 320483002202 Subunit I/IV interface [polypeptide binding]; other site 320483002203 Subunit I/II interface [polypeptide binding]; other site 320483002204 Low-spin heme (heme a) binding site [chemical binding]; other site 320483002205 Subunit I/VIIa interface [polypeptide binding]; other site 320483002206 Subunit I/VIa interface [polypeptide binding]; other site 320483002207 Dimer interface; other site 320483002208 Putative water exit pathway; other site 320483002209 Binuclear center (heme a3/CuB) [ion binding]; other site 320483002210 K-pathway; other site 320483002211 Subunit I/Vb interface [polypeptide binding]; other site 320483002212 Putative proton exit pathway; other site 320483002213 Subunit I/VIb interface; other site 320483002214 Subunit I/VIc interface [polypeptide binding]; other site 320483002215 Electron transfer pathway; other site 320483002216 Subunit I/VIIIb interface [polypeptide binding]; other site 320483002217 Subunit I/VIIb interface [polypeptide binding]; other site 320483002218 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 320483002219 UbiA prenyltransferase family; Region: UbiA; pfam01040 320483002220 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 320483002221 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 320483002222 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 320483002223 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 320483002224 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 320483002225 Preprotein translocase subunit; Region: YajC; pfam02699 320483002226 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320483002227 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320483002228 glutaminase active site [active] 320483002229 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320483002230 dimer interface [polypeptide binding]; other site 320483002231 active site 320483002232 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320483002233 dimer interface [polypeptide binding]; other site 320483002234 active site 320483002235 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 320483002236 DNA polymerase III subunit beta; Validated; Region: PRK05643 320483002237 putative DNA binding surface [nucleotide binding]; other site 320483002238 dimer interface [polypeptide binding]; other site 320483002239 beta-clamp/clamp loader binding surface; other site 320483002240 beta-clamp/translesion DNA polymerase binding surface; other site 320483002241 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 320483002242 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 320483002243 catalytic site [active] 320483002244 putative active site [active] 320483002245 putative substrate binding site [chemical binding]; other site 320483002246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320483002247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320483002248 active site 320483002249 phosphorylation site [posttranslational modification] 320483002250 intermolecular recognition site; other site 320483002251 dimerization interface [polypeptide binding]; other site 320483002252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320483002253 DNA binding site [nucleotide binding] 320483002254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320483002255 non-specific DNA binding site [nucleotide binding]; other site 320483002256 salt bridge; other site 320483002257 Predicted transcriptional regulator [Transcription]; Region: COG2932 320483002258 sequence-specific DNA binding site [nucleotide binding]; other site 320483002259 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 320483002260 Catalytic site [active] 320483002261 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 320483002262 dimer interface [polypeptide binding]; other site 320483002263 substrate binding site [chemical binding]; other site 320483002264 metal binding sites [ion binding]; metal-binding site 320483002265 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 320483002266 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 320483002267 23S rRNA interface [nucleotide binding]; other site 320483002268 L3 interface [polypeptide binding]; other site 320483002269 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 320483002270 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 320483002271 Domain of unknown function DUF59; Region: DUF59; pfam01883 320483002272 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 320483002273 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 320483002274 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 320483002275 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 320483002276 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320483002277 active site 320483002278 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686 320483002279 aconitate hydratase; Validated; Region: PRK09277 320483002280 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 320483002281 substrate binding site [chemical binding]; other site 320483002282 ligand binding site [chemical binding]; other site 320483002283 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 320483002284 substrate binding site [chemical binding]; other site 320483002285 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 320483002286 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 320483002287 ATP-grasp domain; Region: ATP-grasp; pfam02222 320483002288 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 320483002289 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 320483002290 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002291 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002292 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002293 TrbC/VIRB2 family; Region: TrbC; cl01583 320483002294 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002295 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002296 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002297 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 320483002298 HflK protein; Region: hflK; TIGR01933 320483002299 HflC protein; Region: hflC; TIGR01932 320483002300 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 320483002301 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320483002302 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320483002303 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320483002304 protein binding site [polypeptide binding]; other site 320483002305 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320483002306 protein binding site [polypeptide binding]; other site 320483002307 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 320483002308 ribonuclease III; Reviewed; Region: rnc; PRK00102 320483002309 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 320483002310 dimerization interface [polypeptide binding]; other site 320483002311 active site 320483002312 metal binding site [ion binding]; metal-binding site 320483002313 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 320483002314 dsRNA binding site [nucleotide binding]; other site 320483002315 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 320483002316 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 320483002317 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 320483002318 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 320483002319 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 320483002320 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 320483002321 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 320483002322 lipoprotein signal peptidase; Provisional; Region: PRK14775 320483002323 lipoprotein signal peptidase; Provisional; Region: PRK14787 320483002324 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 320483002325 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 320483002326 active site 320483002327 Riboflavin kinase; Region: Flavokinase; smart00904 320483002328 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 320483002329 GSH binding site [chemical binding]; other site 320483002330 catalytic residues [active] 320483002331 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 320483002332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483002333 S-adenosylmethionine binding site [chemical binding]; other site 320483002334 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 320483002335 active site 320483002336 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 320483002337 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320483002338 E3 interaction surface; other site 320483002339 lipoyl attachment site [posttranslational modification]; other site 320483002340 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320483002341 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 320483002342 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 320483002343 trimer interface [polypeptide binding]; other site 320483002344 putative metal binding site [ion binding]; other site 320483002345 pantoate--beta-alanine ligase; Region: panC; TIGR00018 320483002346 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483002347 active site 320483002348 nucleotide binding site [chemical binding]; other site 320483002349 HIGH motif; other site 320483002350 KMSKS motif; other site 320483002351 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 320483002352 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320483002353 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 320483002354 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 320483002355 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 320483002356 DsbD alpha interface [polypeptide binding]; other site 320483002357 catalytic residues [active] 320483002358 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 320483002359 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 320483002360 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 320483002361 active site 320483002362 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 320483002363 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 320483002364 putative substrate binding region [chemical binding]; other site 320483002365 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 320483002366 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320483002367 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320483002368 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320483002369 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320483002370 Surface antigen; Region: Bac_surface_Ag; pfam01103 320483002371 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 320483002372 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 320483002373 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 320483002374 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 320483002375 purine monophosphate binding site [chemical binding]; other site 320483002376 dimer interface [polypeptide binding]; other site 320483002377 putative catalytic residues [active] 320483002378 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 320483002379 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 320483002380 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 320483002381 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 320483002382 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 320483002383 Putative proton exit pathway; other site 320483002384 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320483002385 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320483002386 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320483002387 catalytic residue [active] 320483002388 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 320483002389 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320483002390 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320483002391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320483002392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320483002393 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320483002394 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320483002395 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320483002396 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 320483002397 active site 320483002398 metal binding site [ion binding]; metal-binding site 320483002399 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 320483002400 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 320483002401 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 320483002402 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 320483002403 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 320483002404 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 320483002405 Cell division protein FtsA; Region: FtsA; smart00842 320483002406 Cell division protein FtsA; Region: FtsA; pfam14450 320483002407 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 320483002408 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 320483002409 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 320483002410 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 320483002411 FtsH Extracellular; Region: FtsH_ext; pfam06480 320483002412 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 320483002413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483002414 Walker A motif; other site 320483002415 ATP binding site [chemical binding]; other site 320483002416 Walker B motif; other site 320483002417 arginine finger; other site 320483002418 Peptidase family M41; Region: Peptidase_M41; pfam01434 320483002419 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 320483002420 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 320483002421 SEC-C motif; Region: SEC-C; pfam02810 320483002422 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 320483002423 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 320483002424 CcmB protein; Region: CcmB; cl17444 320483002425 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 320483002426 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 320483002427 AAA domain; Region: AAA_26; pfam13500 320483002428 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 320483002429 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320483002430 P loop; other site 320483002431 GTP binding site [chemical binding]; other site 320483002432 isocitrate dehydrogenase; Validated; Region: PRK09222 320483002433 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 320483002434 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 320483002435 DHH family; Region: DHH; pfam01368 320483002436 DHHA1 domain; Region: DHHA1; pfam02272 320483002437 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 320483002438 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 320483002439 active site 320483002440 NTP binding site [chemical binding]; other site 320483002441 metal binding triad [ion binding]; metal-binding site 320483002442 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 320483002443 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 320483002444 active site 320483002445 multimer interface [polypeptide binding]; other site 320483002446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320483002447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320483002448 non-specific DNA binding site [nucleotide binding]; other site 320483002449 salt bridge; other site 320483002450 sequence-specific DNA binding site [nucleotide binding]; other site 320483002451 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002452 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002453 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002454 Protein of unknown function (DUF1455); Region: DUF1455; pfam07306 320483002455 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002456 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002457 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320483002458 HSP70 interaction site [polypeptide binding]; other site 320483002459 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 320483002460 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 320483002461 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002462 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002463 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002464 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002465 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002466 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 320483002467 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 320483002468 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 320483002469 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 320483002470 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 320483002471 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483002472 active site 320483002473 HIGH motif; other site 320483002474 nucleotide binding site [chemical binding]; other site 320483002475 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320483002476 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320483002477 active site 320483002478 KMSKS motif; other site 320483002479 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 320483002480 tRNA binding surface [nucleotide binding]; other site 320483002481 anticodon binding site; other site 320483002482 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 320483002483 SmpB-tmRNA interface; other site 320483002484 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 320483002485 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 320483002486 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 320483002487 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 320483002488 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320483002489 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 320483002490 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320483002491 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 320483002492 beta subunit interaction interface [polypeptide binding]; other site 320483002493 Walker A motif; other site 320483002494 ATP binding site [chemical binding]; other site 320483002495 Walker B motif; other site 320483002496 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320483002497 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 320483002498 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 320483002499 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 320483002500 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 320483002501 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 320483002502 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320483002503 FtsX-like permease family; Region: FtsX; pfam02687 320483002504 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 320483002505 Glutamate-cysteine ligase; Region: GshA; pfam08886 320483002506 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320483002507 Citrate synthase; Region: Citrate_synt; pfam00285 320483002508 oxalacetate binding site [chemical binding]; other site 320483002509 citrylCoA binding site [chemical binding]; other site 320483002510 coenzyme A binding site [chemical binding]; other site 320483002511 catalytic triad [active] 320483002512 GMP synthase; Reviewed; Region: guaA; PRK00074 320483002513 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 320483002514 AMP/PPi binding site [chemical binding]; other site 320483002515 candidate oxyanion hole; other site 320483002516 catalytic triad [active] 320483002517 potential glutamine specificity residues [chemical binding]; other site 320483002518 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 320483002519 ATP Binding subdomain [chemical binding]; other site 320483002520 Ligand Binding sites [chemical binding]; other site 320483002521 Dimerization subdomain; other site 320483002522 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 320483002523 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320483002524 E3 interaction surface; other site 320483002525 lipoyl attachment site [posttranslational modification]; other site 320483002526 e3 binding domain; Region: E3_binding; pfam02817 320483002527 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320483002528 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 320483002529 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 320483002530 putative active site; other site 320483002531 catalytic residue [active] 320483002532 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 320483002533 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320483002534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320483002535 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 320483002536 Protein export membrane protein; Region: SecD_SecF; cl14618 320483002537 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 320483002538 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320483002539 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 320483002540 substrate-cofactor binding pocket; other site 320483002541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320483002542 catalytic residue [active] 320483002543 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 320483002544 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 320483002545 active site 320483002546 HIGH motif; other site 320483002547 dimer interface [polypeptide binding]; other site 320483002548 KMSKS motif; other site 320483002549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320483002550 RNA binding surface [nucleotide binding]; other site 320483002551 glutamine synthetase, type I; Region: GlnA; TIGR00653 320483002552 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 320483002553 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320483002554 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 320483002555 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 320483002556 Mg++ binding site [ion binding]; other site 320483002557 putative catalytic motif [active] 320483002558 putative substrate binding site [chemical binding]; other site 320483002559 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320483002560 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320483002561 substrate binding pocket [chemical binding]; other site 320483002562 chain length determination region; other site 320483002563 substrate-Mg2+ binding site; other site 320483002564 catalytic residues [active] 320483002565 aspartate-rich region 1; other site 320483002566 active site lid residues [active] 320483002567 aspartate-rich region 2; other site 320483002568 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320483002569 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 320483002570 Walker A/P-loop; other site 320483002571 ATP binding site [chemical binding]; other site 320483002572 Q-loop/lid; other site 320483002573 ABC transporter signature motif; other site 320483002574 Walker B; other site 320483002575 D-loop; other site 320483002576 H-loop/switch region; other site 320483002577 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 320483002578 Permease; Region: Permease; pfam02405 320483002579 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 320483002580 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 320483002581 substrate binding site [chemical binding]; other site 320483002582 hexamer interface [polypeptide binding]; other site 320483002583 metal binding site [ion binding]; metal-binding site 320483002584 DNA polymerase I; Provisional; Region: PRK05755 320483002585 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 320483002586 active site 320483002587 metal binding site 1 [ion binding]; metal-binding site 320483002588 putative 5' ssDNA interaction site; other site 320483002589 metal binding site 3; metal-binding site 320483002590 metal binding site 2 [ion binding]; metal-binding site 320483002591 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 320483002592 putative DNA binding site [nucleotide binding]; other site 320483002593 putative metal binding site [ion binding]; other site 320483002594 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 320483002595 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 320483002596 active site 320483002597 DNA binding site [nucleotide binding] 320483002598 catalytic site [active] 320483002599 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 320483002600 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320483002601 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320483002602 recombination protein F; Reviewed; Region: recF; PRK00064 320483002603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483002604 Walker A/P-loop; other site 320483002605 ATP binding site [chemical binding]; other site 320483002606 Q-loop/lid; other site 320483002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320483002608 ABC transporter signature motif; other site 320483002609 Walker B; other site 320483002610 D-loop; other site 320483002611 H-loop/switch region; other site 320483002612 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002613 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002614 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002615 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002616 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002617 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002618 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002619 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002620 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 320483002621 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 320483002622 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 320483002623 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 320483002624 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320483002625 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320483002626 putative acyl-acceptor binding pocket; other site 320483002627 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320483002628 active site 320483002629 catalytic residues [active] 320483002630 metal binding site [ion binding]; metal-binding site 320483002631 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 320483002632 Fe-S cluster binding site [ion binding]; other site 320483002633 active site 320483002634 outer membrane protein RatB; Provisional; Region: PRK15314 320483002635 excinuclease ABC subunit B; Provisional; Region: PRK05298 320483002636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320483002637 ATP binding site [chemical binding]; other site 320483002638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320483002639 nucleotide binding region [chemical binding]; other site 320483002640 ATP-binding site [chemical binding]; other site 320483002641 Ultra-violet resistance protein B; Region: UvrB; pfam12344 320483002642 UvrB/uvrC motif; Region: UVR; pfam02151 320483002643 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 320483002644 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 320483002645 TrbC/VIRB2 family; Region: TrbC; pfam04956 320483002646 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 320483002647 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002648 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002649 Surface antigen; Region: Surface_Ag_2; pfam01617 320483002650 cell division protein FtsZ; Validated; Region: PRK09330 320483002651 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 320483002652 nucleotide binding site [chemical binding]; other site 320483002653 SulA interaction site; other site 320483002654 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 320483002655 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 320483002656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320483002657 P-loop; other site 320483002658 Magnesium ion binding site [ion binding]; other site 320483002659 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320483002660 Magnesium ion binding site [ion binding]; other site 320483002661 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 320483002662 ParB-like nuclease domain; Region: ParBc; pfam02195 320483002663 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 320483002664 RimM N-terminal domain; Region: RimM; pfam01782 320483002665 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 320483002666 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 320483002667 Competence-damaged protein; Region: CinA; pfam02464 320483002668 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 320483002669 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 320483002670 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 320483002671 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 320483002672 active site 320483002673 dimer interface [polypeptide binding]; other site 320483002674 motif 1; other site 320483002675 motif 2; other site 320483002676 motif 3; other site 320483002677 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 320483002678 anticodon binding site; other site 320483002679 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 320483002680 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 320483002681 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 320483002682 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 320483002683 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 320483002684 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 320483002685 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 320483002686 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320483002687 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 320483002688 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964 320483002689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320483002690 Walker A motif; other site 320483002691 ATP binding site [chemical binding]; other site 320483002692 Walker B motif; other site 320483002693 arginine finger; other site 320483002694 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 320483002695 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 320483002696 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 320483002697 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 320483002698 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 320483002699 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 320483002700 conserved cys residue [active] 320483002701 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 320483002702 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 320483002703 S-adenosylmethionine synthetase; Validated; Region: PRK05250 320483002704 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 320483002705 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 320483002706 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 320483002707 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320483002708 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 320483002709 motif 1; other site 320483002710 dimer interface [polypeptide binding]; other site 320483002711 active site 320483002712 motif 2; other site 320483002713 motif 3; other site 320483002714 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 320483002715 chaperone protein DnaJ; Provisional; Region: PRK10767 320483002716 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320483002717 HSP70 interaction site [polypeptide binding]; other site 320483002718 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 320483002719 substrate binding site [polypeptide binding]; other site 320483002720 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 320483002721 Zn binding sites [ion binding]; other site 320483002722 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 320483002723 dimer interface [polypeptide binding]; other site 320483002724 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 320483002725 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 320483002726 dimerization interface [polypeptide binding]; other site 320483002727 active site 320483002728 membrane protein; Provisional; Region: PRK14396 320483002729 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 320483002730 active site 320483002731 putative DNA-binding cleft [nucleotide binding]; other site 320483002732 dimer interface [polypeptide binding]; other site 320483002733 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 320483002734 Subunit III/VIIa interface [polypeptide binding]; other site 320483002735 Phospholipid binding site [chemical binding]; other site 320483002736 Subunit I/III interface [polypeptide binding]; other site 320483002737 Subunit III/VIb interface [polypeptide binding]; other site 320483002738 Subunit III/VIa interface; other site 320483002739 Subunit III/Vb interface [polypeptide binding]; other site 320483002740 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 320483002741 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320483002742 Transporter associated domain; Region: CorC_HlyC; smart01091 320483002743 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 320483002744 Phage-related protein [Function unknown]; Region: COG4695 320483002745 Phage portal protein; Region: Phage_portal; pfam04860 320483002746 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 320483002747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483002748 S-adenosylmethionine binding site [chemical binding]; other site 320483002749 quinolinate synthetase; Provisional; Region: PRK09375 320483002750 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 320483002751 4Fe-4S binding domain; Region: Fer4; pfam00037 320483002752 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 320483002753 ketol-acid reductoisomerase; Provisional; Region: PRK05479 320483002754 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 320483002755 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 320483002756 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 320483002757 type IV secretion system component VirD4; Provisional; Region: PRK13897 320483002758 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 320483002759 Walker A motif; other site 320483002760 ATP binding site [chemical binding]; other site 320483002761 Walker B motif; other site 320483002762 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 320483002763 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320483002764 Walker A motif; other site 320483002765 hexamer interface [polypeptide binding]; other site 320483002766 ATP binding site [chemical binding]; other site 320483002767 Walker B motif; other site 320483002768 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 320483002769 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 320483002770 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 320483002771 VirB7 interaction site; other site 320483002772 VirB8 protein; Region: VirB8; pfam04335 320483002773 GTP cyclohydrolase; Provisional; Region: PRK08815 320483002774 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 320483002775 dimerization interface [polypeptide binding]; other site 320483002776 active site 320483002777 Tetratricopeptide repeat; Region: TPR_16; pfam13432 320483002778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320483002779 TPR motif; other site 320483002780 binding surface 320483002781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320483002782 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320483002783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320483002784 S-adenosylmethionine binding site [chemical binding]; other site 320483002785 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 320483002786 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320483002787 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320483002788 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 320483002789 Phosphoglycerate kinase; Region: PGK; pfam00162 320483002790 substrate binding site [chemical binding]; other site 320483002791 hinge regions; other site 320483002792 ADP binding site [chemical binding]; other site 320483002793 catalytic site [active] 320483002794 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 320483002795 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 320483002796 generic binding surface II; other site 320483002797 generic binding surface I; other site 320483002798 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 320483002799 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 320483002800 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 320483002801 trimer interface [polypeptide binding]; other site 320483002802 active site 320483002803 substrate binding site [chemical binding]; other site 320483002804 CoA binding site [chemical binding]; other site 320483002805 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 320483002806 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 320483002807 trmE is a tRNA modification GTPase; Region: trmE; cd04164 320483002808 G1 box; other site 320483002809 GTP/Mg2+ binding site [chemical binding]; other site 320483002810 Switch I region; other site 320483002811 G2 box; other site 320483002812 Switch II region; other site 320483002813 G3 box; other site 320483002814 G4 box; other site 320483002815 G5 box; other site 320483002816 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 320483002817 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 320483002818 Flavoprotein; Region: Flavoprotein; pfam02441 320483002819 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 320483002820 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 320483002821 ssDNA binding site; other site 320483002822 generic binding surface II; other site 320483002823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320483002824 ATP binding site [chemical binding]; other site 320483002825 putative Mg++ binding site [ion binding]; other site 320483002826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320483002827 nucleotide binding region [chemical binding]; other site 320483002828 ATP-binding site [chemical binding]; other site 320483002829 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 320483002830 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 320483002831 putative NAD(P) binding site [chemical binding]; other site 320483002832 active site 320483002833 amidophosphoribosyltransferase; Provisional; Region: PRK09123 320483002834 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 320483002835 active site 320483002836 tetramer interface [polypeptide binding]; other site 320483002837 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320483002838 active site 320483002839 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 320483002840 putative active site [active] 320483002841 catalytic residue [active] 320483002842 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 320483002843 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 320483002844 5S rRNA interface [nucleotide binding]; other site 320483002845 CTC domain interface [polypeptide binding]; other site 320483002846 L16 interface [polypeptide binding]; other site 320483002847 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 320483002848 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320483002849 active site 320483002850 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 320483002851 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 320483002852 metal binding site [ion binding]; metal-binding site 320483002853 dimer interface [polypeptide binding]; other site 320483002854 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 320483002855 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 320483002856 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 320483002857 TrkA-N domain; Region: TrkA_N; pfam02254 320483002858 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 320483002859 putative catalytic residue [active] 320483002860 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 320483002861 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 320483002862 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 320483002863 alpha subunit interface [polypeptide binding]; other site 320483002864 TPP binding site [chemical binding]; other site 320483002865 heterodimer interface [polypeptide binding]; other site 320483002866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320483002867 protease TldD; Provisional; Region: tldD; PRK10735 320483002868 GTP-binding protein YchF; Reviewed; Region: PRK09601 320483002869 YchF GTPase; Region: YchF; cd01900 320483002870 G1 box; other site 320483002871 GTP/Mg2+ binding site [chemical binding]; other site 320483002872 Switch I region; other site 320483002873 G2 box; other site 320483002874 Switch II region; other site 320483002875 G3 box; other site 320483002876 G4 box; other site 320483002877 G5 box; other site 320483002878 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 320483002879 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 320483002880 homotrimer interaction site [polypeptide binding]; other site 320483002881 zinc binding site [ion binding]; other site 320483002882 CDP-binding sites; other site 320483002883 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 320483002884 substrate binding site; other site 320483002885 dimer interface; other site