-- dump date 20140618_204238 -- class Genbank::misc_feature -- table misc_feature_note -- id note 234826000001 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 234826000002 AIR carboxylase; Region: AIRC; pfam00731 234826000003 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234826000004 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234826000005 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 234826000006 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 234826000007 IHF - DNA interface [nucleotide binding]; other site 234826000008 IHF dimer interface [polypeptide binding]; other site 234826000009 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 234826000010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234826000011 DNA binding residues [nucleotide binding] 234826000012 ribonuclease E; Reviewed; Region: rne; PRK10811 234826000013 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234826000014 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234826000015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234826000016 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234826000017 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 234826000018 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 234826000019 active site 234826000020 HIGH motif; other site 234826000021 dimer interface [polypeptide binding]; other site 234826000022 KMSKS motif; other site 234826000023 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826000024 GrpE; Region: GrpE; pfam01025 234826000025 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 234826000026 dimer interface [polypeptide binding]; other site 234826000027 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 234826000028 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 234826000029 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 234826000030 catalytic motif [active] 234826000031 Zn binding site [ion binding]; other site 234826000032 RibD C-terminal domain; Region: RibD_C; cl17279 234826000033 CTP synthetase; Validated; Region: pyrG; PRK05380 234826000034 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 234826000035 Catalytic site [active] 234826000036 active site 234826000037 UTP binding site [chemical binding]; other site 234826000038 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 234826000039 active site 234826000040 putative oxyanion hole; other site 234826000041 catalytic triad [active] 234826000042 Preprotein translocase SecG subunit; Region: SecG; pfam03840 234826000043 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234826000044 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 234826000045 active site 234826000046 DNA binding site [nucleotide binding] 234826000047 Int/Topo IB signature motif; other site 234826000048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234826000049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234826000050 Walker A/P-loop; other site 234826000051 ATP binding site [chemical binding]; other site 234826000052 Q-loop/lid; other site 234826000053 ABC transporter signature motif; other site 234826000054 Walker B; other site 234826000055 D-loop; other site 234826000056 H-loop/switch region; other site 234826000057 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 234826000058 Malic enzyme, N-terminal domain; Region: malic; pfam00390 234826000059 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 234826000060 putative NAD(P) binding site [chemical binding]; other site 234826000061 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 234826000062 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12662 234826000063 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826000064 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000065 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 234826000066 thiS-thiF/thiG interaction site; other site 234826000067 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 234826000068 ThiS interaction site; other site 234826000069 putative active site [active] 234826000070 tetramer interface [polypeptide binding]; other site 234826000071 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 234826000072 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 234826000073 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826000074 active site 234826000075 HIGH motif; other site 234826000076 nucleotide binding site [chemical binding]; other site 234826000077 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234826000078 active site 234826000079 KMSKS motif; other site 234826000080 SurA N-terminal domain; Region: SurA_N_3; cl07813 234826000081 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 234826000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826000083 S-adenosylmethionine binding site [chemical binding]; other site 234826000084 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000085 transcription termination factor Rho; Provisional; Region: rho; PRK09376 234826000086 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 234826000087 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 234826000088 RNA binding site [nucleotide binding]; other site 234826000089 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 234826000090 multimer interface [polypeptide binding]; other site 234826000091 Walker A motif; other site 234826000092 ATP binding site [chemical binding]; other site 234826000093 Walker B motif; other site 234826000094 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 234826000095 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 234826000096 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 234826000097 23S rRNA binding site [nucleotide binding]; other site 234826000098 L21 binding site [polypeptide binding]; other site 234826000099 L13 binding site [polypeptide binding]; other site 234826000100 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 234826000101 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 234826000102 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 234826000103 dimer interface [polypeptide binding]; other site 234826000104 motif 1; other site 234826000105 active site 234826000106 motif 2; other site 234826000107 motif 3; other site 234826000108 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 234826000109 NADP binding site [chemical binding]; other site 234826000110 substrate binding pocket [chemical binding]; other site 234826000111 active site 234826000112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234826000113 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 234826000114 active site 234826000115 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 234826000116 active site 234826000117 substrate binding site [chemical binding]; other site 234826000118 CoA binding site [chemical binding]; other site 234826000119 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 234826000120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000121 metabolite-proton symporter; Region: 2A0106; TIGR00883 234826000122 putative substrate translocation pore; other site 234826000123 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000124 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 234826000125 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 234826000126 Uncharacterized conserved protein [Function unknown]; Region: COG2835 234826000127 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234826000128 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 234826000129 ATP cone domain; Region: ATP-cone; pfam03477 234826000130 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 234826000131 mce related protein; Region: MCE; pfam02470 234826000132 Surface antigen; Region: Surface_Ag_2; pfam01617 234826000133 Surface antigen; Region: Surface_Ag_2; pfam01617 234826000134 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000135 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000136 recombinase A; Provisional; Region: recA; PRK09354 234826000137 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 234826000138 hexamer interface [polypeptide binding]; other site 234826000139 Walker A motif; other site 234826000140 ATP binding site [chemical binding]; other site 234826000141 Walker B motif; other site 234826000142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234826000143 active site 234826000144 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 234826000145 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 234826000146 ATP binding site [chemical binding]; other site 234826000147 substrate interface [chemical binding]; other site 234826000148 Surface antigen; Region: Surface_Ag_2; pfam01617 234826000149 Membrane transport protein; Region: Mem_trans; cl09117 234826000150 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 234826000151 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 234826000152 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234826000153 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234826000154 catalytic residues [active] 234826000155 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 234826000156 VirB7 interaction site; other site 234826000157 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 234826000158 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234826000159 tetramer interface [polypeptide binding]; other site 234826000160 TPP-binding site [chemical binding]; other site 234826000161 heterodimer interface [polypeptide binding]; other site 234826000162 phosphorylation loop region [posttranslational modification] 234826000163 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234826000164 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234826000165 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 234826000166 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 234826000167 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 234826000168 active site 234826000169 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 234826000170 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 234826000171 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234826000172 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234826000173 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 234826000174 thymidylate kinase; Validated; Region: tmk; PRK00698 234826000175 TMP-binding site; other site 234826000176 ATP-binding site [chemical binding]; other site 234826000177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000178 putative substrate translocation pore; other site 234826000179 Tim44-like domain; Region: Tim44; pfam04280 234826000180 preprotein translocase subunit SecB; Validated; Region: PRK05751 234826000181 SecA binding site; other site 234826000182 Preprotein binding site; other site 234826000183 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234826000184 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 234826000185 catalytic residues [active] 234826000186 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234826000187 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234826000188 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234826000189 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234826000190 Peptidase family M23; Region: Peptidase_M23; pfam01551 234826000191 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234826000192 FMN binding site [chemical binding]; other site 234826000193 substrate binding site [chemical binding]; other site 234826000194 putative catalytic residue [active] 234826000195 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 234826000196 Lumazine binding domain; Region: Lum_binding; pfam00677 234826000197 Lumazine binding domain; Region: Lum_binding; pfam00677 234826000198 Major surface protein 1B; Region: MSP1b; pfam03429 234826000199 Major surface protein 1B; Region: MSP1b; pfam03429 234826000200 Major surface protein 1B; Region: MSP1b; pfam03429 234826000201 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 234826000202 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 234826000203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234826000204 ATP binding site [chemical binding]; other site 234826000205 putative Mg++ binding site [ion binding]; other site 234826000206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234826000207 nucleotide binding region [chemical binding]; other site 234826000208 ATP-binding site [chemical binding]; other site 234826000209 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 234826000210 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 234826000211 RNA/DNA hybrid binding site [nucleotide binding]; other site 234826000212 active site 234826000213 Protein of unknown function; Region: DUF3971; pfam13116 234826000214 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 234826000215 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 234826000216 putative nucleotide binding site [chemical binding]; other site 234826000217 uridine monophosphate binding site [chemical binding]; other site 234826000218 homohexameric interface [polypeptide binding]; other site 234826000219 ribosome recycling factor; Reviewed; Region: frr; PRK00083 234826000220 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 234826000221 hinge region; other site 234826000222 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 234826000223 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 234826000224 catalytic residue [active] 234826000225 putative FPP diphosphate binding site; other site 234826000226 putative FPP binding hydrophobic cleft; other site 234826000227 dimer interface [polypeptide binding]; other site 234826000228 putative IPP diphosphate binding site; other site 234826000229 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 234826000230 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 234826000231 Major surface protein 1B; Region: MSP1b; pfam03429 234826000232 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 234826000233 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 234826000234 ATP binding site [chemical binding]; other site 234826000235 active site 234826000236 substrate binding site [chemical binding]; other site 234826000237 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 234826000238 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 234826000239 dimer interface [polypeptide binding]; other site 234826000240 motif 1; other site 234826000241 active site 234826000242 motif 2; other site 234826000243 motif 3; other site 234826000244 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 234826000245 anticodon binding site; other site 234826000246 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234826000247 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 234826000248 catalytic residues [active] 234826000249 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 234826000250 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 234826000251 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 234826000252 oligomerization interface [polypeptide binding]; other site 234826000253 active site 234826000254 metal binding site [ion binding]; metal-binding site 234826000255 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 234826000256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826000257 Walker A/P-loop; other site 234826000258 ATP binding site [chemical binding]; other site 234826000259 Q-loop/lid; other site 234826000260 ABC transporter signature motif; other site 234826000261 Walker B; other site 234826000262 D-loop; other site 234826000263 H-loop/switch region; other site 234826000264 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 234826000265 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 234826000266 hinge; other site 234826000267 active site 234826000268 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 234826000269 trimer interface [polypeptide binding]; other site 234826000270 active site 234826000271 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 234826000272 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 234826000273 putative NAD(P) binding site [chemical binding]; other site 234826000274 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234826000275 DNA-binding site [nucleotide binding]; DNA binding site 234826000276 RNA-binding motif; other site 234826000277 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 234826000278 HAMP domain; Region: HAMP; pfam00672 234826000279 dimerization interface [polypeptide binding]; other site 234826000280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234826000281 dimer interface [polypeptide binding]; other site 234826000282 phosphorylation site [posttranslational modification] 234826000283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826000284 ATP binding site [chemical binding]; other site 234826000285 Mg2+ binding site [ion binding]; other site 234826000286 G-X-G motif; other site 234826000287 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 234826000288 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 234826000289 catalytic site [active] 234826000290 putative active site [active] 234826000291 putative substrate binding site [chemical binding]; other site 234826000292 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 234826000293 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 234826000294 nucleotide binding pocket [chemical binding]; other site 234826000295 K-X-D-G motif; other site 234826000296 catalytic site [active] 234826000297 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 234826000298 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 234826000299 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 234826000300 Dimer interface [polypeptide binding]; other site 234826000301 BRCT sequence motif; other site 234826000302 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 234826000303 putative GSH binding site [chemical binding]; other site 234826000304 catalytic residues [active] 234826000305 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 234826000306 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 234826000307 catalytic residues [active] 234826000308 central insert; other site 234826000309 DNA repair protein RadA; Provisional; Region: PRK11823 234826000310 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234826000311 Walker A motif; other site 234826000312 ATP binding site [chemical binding]; other site 234826000313 Walker B motif; other site 234826000314 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 234826000315 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 234826000316 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 234826000317 Colicin V production protein; Region: Colicin_V; pfam02674 234826000318 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 234826000319 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 234826000320 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 234826000321 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 234826000322 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 234826000323 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 234826000324 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 234826000325 dimer interface [polypeptide binding]; other site 234826000326 active site 234826000327 glycine-pyridoxal phosphate binding site [chemical binding]; other site 234826000328 folate binding site [chemical binding]; other site 234826000329 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 234826000330 putative iron binding site [ion binding]; other site 234826000331 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 234826000332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234826000333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826000334 Walker A/P-loop; other site 234826000335 ATP binding site [chemical binding]; other site 234826000336 Q-loop/lid; other site 234826000337 ABC transporter signature motif; other site 234826000338 Walker B; other site 234826000339 D-loop; other site 234826000340 H-loop/switch region; other site 234826000341 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 234826000342 L-aspartate oxidase; Provisional; Region: PRK06175 234826000343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234826000344 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 234826000345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234826000346 catalytic loop [active] 234826000347 iron binding site [ion binding]; other site 234826000348 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 234826000349 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 234826000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000351 putative substrate translocation pore; other site 234826000352 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 234826000353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826000354 Walker A motif; other site 234826000355 ATP binding site [chemical binding]; other site 234826000356 Walker B motif; other site 234826000357 arginine finger; other site 234826000358 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 234826000359 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 234826000360 RuvA N terminal domain; Region: RuvA_N; pfam01330 234826000361 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 234826000362 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 234826000363 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 234826000364 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 234826000365 catalytic site [active] 234826000366 G-X2-G-X-G-K; other site 234826000367 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234826000368 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 234826000369 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14187 234826000370 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 234826000371 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 234826000372 homodimer interface [polypeptide binding]; other site 234826000373 NADP binding site [chemical binding]; other site 234826000374 substrate binding site [chemical binding]; other site 234826000375 Major surface protein 1B; Region: MSP1b; pfam03429 234826000376 Protein involved in mRNA turnover and stability [RNA processing and modification]; Region: SSM4; COG5183 234826000377 Major surface protein 1B; Region: MSP1b; pfam03429 234826000378 Major surface protein 1B; Region: MSP1b; pfam03429 234826000379 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 234826000380 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234826000381 Cytochrome c2 [Energy production and conversion]; Region: COG3474 234826000382 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 234826000383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826000384 pyruvate phosphate dikinase; Provisional; Region: PRK09279 234826000385 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 234826000386 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234826000387 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 234826000388 RDD family; Region: RDD; pfam06271 234826000389 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234826000390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234826000391 motif II; other site 234826000392 GAD domain; Region: GAD; pfam02938 234826000393 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234826000394 active site 234826000395 motif 3; other site 234826000396 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 234826000397 dimer interface [polypeptide binding]; other site 234826000398 anticodon binding site; other site 234826000399 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234826000400 motif 1; other site 234826000401 dimer interface [polypeptide binding]; other site 234826000402 active site 234826000403 motif 2; other site 234826000404 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 234826000405 BON domain; Region: BON; pfam04972 234826000406 BON domain; Region: BON; pfam04972 234826000407 glutathione synthetase, prokaryotic; Region: glut_syn; TIGR01380 234826000408 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 234826000409 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 234826000410 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 234826000411 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 234826000412 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234826000413 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 234826000414 Cell division protein FtsQ; Region: FtsQ; pfam03799 234826000415 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 234826000416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234826000417 active site 234826000418 phosphorylation site [posttranslational modification] 234826000419 intermolecular recognition site; other site 234826000420 dimerization interface [polypeptide binding]; other site 234826000421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826000422 Walker A motif; other site 234826000423 ATP binding site [chemical binding]; other site 234826000424 Walker B motif; other site 234826000425 arginine finger; other site 234826000426 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234826000427 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826000428 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 234826000429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234826000430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234826000431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234826000432 putative hydrolase; Provisional; Region: PRK02113 234826000433 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 234826000434 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234826000435 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 234826000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234826000437 dimer interface [polypeptide binding]; other site 234826000438 conserved gate region; other site 234826000439 putative PBP binding loops; other site 234826000440 ABC-ATPase subunit interface; other site 234826000441 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 234826000442 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 234826000443 motif 1; other site 234826000444 active site 234826000445 motif 2; other site 234826000446 motif 3; other site 234826000447 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 234826000448 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 234826000449 CoA binding domain; Region: CoA_binding; smart00881 234826000450 CoA-ligase; Region: Ligase_CoA; pfam00549 234826000451 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 234826000452 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 234826000453 CoA-ligase; Region: Ligase_CoA; pfam00549 234826000454 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 234826000455 PBP superfamily domain; Region: PBP_like_2; cl17296 234826000456 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 234826000457 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 234826000458 Cu(I) binding site [ion binding]; other site 234826000459 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 234826000460 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234826000461 FMN binding site [chemical binding]; other site 234826000462 substrate binding site [chemical binding]; other site 234826000463 putative catalytic residue [active] 234826000464 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 234826000465 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 234826000466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234826000467 dimer interface [polypeptide binding]; other site 234826000468 conserved gate region; other site 234826000469 putative PBP binding loops; other site 234826000470 ABC-ATPase subunit interface; other site 234826000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234826000472 dimer interface [polypeptide binding]; other site 234826000473 conserved gate region; other site 234826000474 putative PBP binding loops; other site 234826000475 ABC-ATPase subunit interface; other site 234826000476 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 234826000477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 234826000478 HlyD family secretion protein; Region: HlyD_3; pfam13437 234826000479 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 234826000480 COQ9; Region: COQ9; pfam08511 234826000481 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 234826000482 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234826000483 translocation protein TolB; Provisional; Region: tolB; PRK05137 234826000484 TolB amino-terminal domain; Region: TolB_N; pfam04052 234826000485 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234826000486 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 234826000487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234826000488 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 234826000489 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234826000490 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234826000491 active site 234826000492 metal binding site [ion binding]; metal-binding site 234826000493 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 234826000494 S17 interaction site [polypeptide binding]; other site 234826000495 S8 interaction site; other site 234826000496 16S rRNA interaction site [nucleotide binding]; other site 234826000497 streptomycin interaction site [chemical binding]; other site 234826000498 23S rRNA interaction site [nucleotide binding]; other site 234826000499 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 234826000500 30S ribosomal protein S7; Validated; Region: PRK05302 234826000501 elongation factor G; Reviewed; Region: PRK00007 234826000502 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 234826000503 G1 box; other site 234826000504 putative GEF interaction site [polypeptide binding]; other site 234826000505 GTP/Mg2+ binding site [chemical binding]; other site 234826000506 Switch I region; other site 234826000507 G2 box; other site 234826000508 G3 box; other site 234826000509 Switch II region; other site 234826000510 G4 box; other site 234826000511 G5 box; other site 234826000512 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 234826000513 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 234826000514 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 234826000515 elongation factor Tu; Reviewed; Region: PRK00049 234826000516 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 234826000517 G1 box; other site 234826000518 GEF interaction site [polypeptide binding]; other site 234826000519 GTP/Mg2+ binding site [chemical binding]; other site 234826000520 Switch I region; other site 234826000521 G2 box; other site 234826000522 G3 box; other site 234826000523 Switch II region; other site 234826000524 G4 box; other site 234826000525 G5 box; other site 234826000526 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 234826000527 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 234826000528 Antibiotic Binding Site [chemical binding]; other site 234826000529 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 234826000530 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 234826000531 putative homodimer interface [polypeptide binding]; other site 234826000532 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 234826000533 heterodimer interface [polypeptide binding]; other site 234826000534 homodimer interface [polypeptide binding]; other site 234826000535 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 234826000536 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 234826000537 23S rRNA interface [nucleotide binding]; other site 234826000538 L7/L12 interface [polypeptide binding]; other site 234826000539 putative thiostrepton binding site; other site 234826000540 L25 interface [polypeptide binding]; other site 234826000541 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 234826000542 mRNA/rRNA interface [nucleotide binding]; other site 234826000543 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 234826000544 23S rRNA interface [nucleotide binding]; other site 234826000545 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 234826000546 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 234826000547 peripheral dimer interface [polypeptide binding]; other site 234826000548 core dimer interface [polypeptide binding]; other site 234826000549 L10 interface [polypeptide binding]; other site 234826000550 L11 interface [polypeptide binding]; other site 234826000551 putative EF-Tu interaction site [polypeptide binding]; other site 234826000552 putative EF-G interaction site [polypeptide binding]; other site 234826000553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 234826000554 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 234826000555 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 234826000556 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 234826000557 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 234826000558 RPB3 interaction site [polypeptide binding]; other site 234826000559 RPB1 interaction site [polypeptide binding]; other site 234826000560 RPB11 interaction site [polypeptide binding]; other site 234826000561 RPB10 interaction site [polypeptide binding]; other site 234826000562 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 234826000563 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 234826000564 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 234826000565 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 234826000566 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 234826000567 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 234826000568 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 234826000569 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 234826000570 DNA binding site [nucleotide binding] 234826000571 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 234826000572 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 234826000573 RNA/DNA hybrid binding site [nucleotide binding]; other site 234826000574 active site 234826000575 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 234826000576 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 234826000577 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 234826000578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234826000579 catalytic residue [active] 234826000580 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 234826000581 pantothenate kinase; Reviewed; Region: PRK13318 234826000582 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 234826000583 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 234826000584 quinone interaction residues [chemical binding]; other site 234826000585 active site 234826000586 catalytic residues [active] 234826000587 FMN binding site [chemical binding]; other site 234826000588 substrate binding site [chemical binding]; other site 234826000589 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 234826000590 active site 234826000591 catalytic residues [active] 234826000592 metal binding site [ion binding]; metal-binding site 234826000593 Predicted esterase [General function prediction only]; Region: COG0400 234826000594 putative hydrolase; Provisional; Region: PRK11460 234826000595 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 234826000596 nucleophile elbow; other site 234826000597 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 234826000598 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234826000599 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 234826000600 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 234826000601 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234826000602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234826000603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234826000604 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 234826000605 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234826000606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234826000607 catalytic residue [active] 234826000608 BolA-like protein; Region: BolA; pfam01722 234826000609 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 234826000610 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 234826000611 putative active site [active] 234826000612 putative PHP Thumb interface [polypeptide binding]; other site 234826000613 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 234826000614 generic binding surface I; other site 234826000615 generic binding surface II; other site 234826000616 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 234826000617 putative active site [active] 234826000618 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 234826000619 Iron-sulfur protein interface; other site 234826000620 proximal quinone binding site [chemical binding]; other site 234826000621 SdhD (CybS) interface [polypeptide binding]; other site 234826000622 proximal heme binding site [chemical binding]; other site 234826000623 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 234826000624 putative SdhC subunit interface [polypeptide binding]; other site 234826000625 putative proximal heme binding site [chemical binding]; other site 234826000626 putative Iron-sulfur protein interface [polypeptide binding]; other site 234826000627 putative proximal quinone binding site; other site 234826000628 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 234826000629 dimer interface [polypeptide binding]; other site 234826000630 substrate binding site [chemical binding]; other site 234826000631 ATP binding site [chemical binding]; other site 234826000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234826000633 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 234826000634 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234826000635 Domain of unknown function DUF20; Region: UPF0118; pfam01594 234826000636 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 234826000637 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 234826000638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234826000639 RNA binding surface [nucleotide binding]; other site 234826000640 PAS fold; Region: PAS_7; pfam12860 234826000641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234826000642 Coenzyme A binding pocket [chemical binding]; other site 234826000643 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 234826000644 tetramer interfaces [polypeptide binding]; other site 234826000645 binuclear metal-binding site [ion binding]; other site 234826000646 trigger factor; Region: tig; TIGR00115 234826000647 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234826000648 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 234826000649 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 234826000650 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234826000651 oligomer interface [polypeptide binding]; other site 234826000652 active site residues [active] 234826000653 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 234826000654 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 234826000655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826000656 Walker A motif; other site 234826000657 ATP binding site [chemical binding]; other site 234826000658 Walker B motif; other site 234826000659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234826000660 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 234826000661 Found in ATP-dependent protease La (LON); Region: LON; smart00464 234826000662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826000663 Walker A motif; other site 234826000664 ATP binding site [chemical binding]; other site 234826000665 Walker B motif; other site 234826000666 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 234826000667 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 234826000668 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 234826000669 putative active site [active] 234826000670 substrate binding site [chemical binding]; other site 234826000671 putative cosubstrate binding site; other site 234826000672 catalytic site [active] 234826000673 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 234826000674 substrate binding site [chemical binding]; other site 234826000675 hypothetical protein; Validated; Region: PRK01415 234826000676 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 234826000677 active site residue [active] 234826000678 PEP synthetase regulatory protein; Provisional; Region: PRK05339 234826000679 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 234826000680 thiamine phosphate binding site [chemical binding]; other site 234826000681 active site 234826000682 pyrophosphate binding site [ion binding]; other site 234826000683 Domain of unknown function DUF21; Region: DUF21; pfam01595 234826000684 gliding motility-associated protein GldE; Region: GldE; TIGR03520 234826000685 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234826000686 Transporter associated domain; Region: CorC_HlyC; smart01091 234826000687 YGGT family; Region: YGGT; pfam02325 234826000688 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 234826000689 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 234826000690 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234826000691 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 234826000692 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 234826000693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234826000694 inhibitor-cofactor binding pocket; inhibition site 234826000695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234826000696 catalytic residue [active] 234826000697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234826000698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234826000699 dimer interface [polypeptide binding]; other site 234826000700 phosphorylation site [posttranslational modification] 234826000701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826000702 ATP binding site [chemical binding]; other site 234826000703 Mg2+ binding site [ion binding]; other site 234826000704 G-X-G motif; other site 234826000705 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 234826000706 TolR protein; Region: tolR; TIGR02801 234826000707 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 234826000708 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 234826000709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826000710 ATP binding site [chemical binding]; other site 234826000711 Mg2+ binding site [ion binding]; other site 234826000712 G-X-G motif; other site 234826000713 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 234826000714 ATP binding site [chemical binding]; other site 234826000715 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 234826000716 DNA protecting protein DprA; Region: dprA; TIGR00732 234826000717 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 234826000718 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 234826000719 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 234826000720 Ligand Binding Site [chemical binding]; other site 234826000721 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234826000722 Walker A motif; other site 234826000723 ATP binding site [chemical binding]; other site 234826000724 Walker B motif; other site 234826000725 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 234826000726 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234826000727 dimer interface [polypeptide binding]; other site 234826000728 active site 234826000729 acyl carrier protein; Provisional; Region: acpP; PRK00982 234826000730 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 234826000731 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 234826000732 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 234826000733 diiron binding motif [ion binding]; other site 234826000734 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 234826000735 Part of AAA domain; Region: AAA_19; pfam13245 234826000736 Family description; Region: UvrD_C_2; pfam13538 234826000737 DNA gyrase subunit A; Validated; Region: PRK05560 234826000738 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 234826000739 CAP-like domain; other site 234826000740 active site 234826000741 primary dimer interface [polypeptide binding]; other site 234826000742 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234826000743 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234826000744 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234826000745 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234826000746 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 234826000747 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234826000748 minor groove reading motif; other site 234826000749 helix-hairpin-helix signature motif; other site 234826000750 substrate binding pocket [chemical binding]; other site 234826000751 active site 234826000752 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 234826000753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 234826000754 heat shock protein 90; Provisional; Region: PRK05218 234826000755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826000756 ATP binding site [chemical binding]; other site 234826000757 Mg2+ binding site [ion binding]; other site 234826000758 G-X-G motif; other site 234826000759 adenylosuccinate lyase; Provisional; Region: PRK07492 234826000760 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 234826000761 tetramer interface [polypeptide binding]; other site 234826000762 active site 234826000763 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 234826000764 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 234826000765 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 234826000766 GIY-YIG motif/motif A; other site 234826000767 active site 234826000768 catalytic site [active] 234826000769 putative DNA binding site [nucleotide binding]; other site 234826000770 metal binding site [ion binding]; metal-binding site 234826000771 UvrB/uvrC motif; Region: UVR; pfam02151 234826000772 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 234826000773 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 234826000774 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 234826000775 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 234826000776 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 234826000777 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 234826000778 C-terminal domain interface [polypeptide binding]; other site 234826000779 GSH binding site (G-site) [chemical binding]; other site 234826000780 dimer interface [polypeptide binding]; other site 234826000781 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 234826000782 N-terminal domain interface [polypeptide binding]; other site 234826000783 dimer interface [polypeptide binding]; other site 234826000784 substrate binding pocket (H-site) [chemical binding]; other site 234826000785 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 234826000786 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 234826000787 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 234826000788 Walker A/P-loop; other site 234826000789 ATP binding site [chemical binding]; other site 234826000790 Q-loop/lid; other site 234826000791 ABC transporter signature motif; other site 234826000792 Walker B; other site 234826000793 D-loop; other site 234826000794 H-loop/switch region; other site 234826000795 TOBE domain; Region: TOBE_2; pfam08402 234826000796 recombination protein RecR; Reviewed; Region: recR; PRK00076 234826000797 RecR protein; Region: RecR; pfam02132 234826000798 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 234826000799 putative active site [active] 234826000800 putative metal-binding site [ion binding]; other site 234826000801 tetramer interface [polypeptide binding]; other site 234826000802 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 234826000803 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 234826000804 metal binding site [ion binding]; metal-binding site 234826000805 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 234826000806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826000807 Walker A/P-loop; other site 234826000808 ATP binding site [chemical binding]; other site 234826000809 Q-loop/lid; other site 234826000810 ABC transporter signature motif; other site 234826000811 Walker B; other site 234826000812 D-loop; other site 234826000813 H-loop/switch region; other site 234826000814 ABC1 family; Region: ABC1; cl17513 234826000815 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 234826000816 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 234826000817 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 234826000818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234826000819 FeS/SAM binding site; other site 234826000820 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 234826000821 Putative phage tail protein; Region: Phage-tail_3; pfam13550 234826000822 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 234826000823 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 234826000824 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 234826000825 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 234826000826 TPP-binding site [chemical binding]; other site 234826000827 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 234826000828 dimer interface [polypeptide binding]; other site 234826000829 PYR/PP interface [polypeptide binding]; other site 234826000830 TPP binding site [chemical binding]; other site 234826000831 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 234826000832 Phage capsid family; Region: Phage_capsid; pfam05065 234826000833 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234826000834 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 234826000835 dimer interface [polypeptide binding]; other site 234826000836 active site 234826000837 catalytic residue [active] 234826000838 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 234826000839 nucleotide binding site/active site [active] 234826000840 HIT family signature motif; other site 234826000841 catalytic residue [active] 234826000842 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 234826000843 MutS domain I; Region: MutS_I; pfam01624 234826000844 MutS domain II; Region: MutS_II; pfam05188 234826000845 MutS domain III; Region: MutS_III; pfam05192 234826000846 MutS domain V; Region: MutS_V; pfam00488 234826000847 Walker A/P-loop; other site 234826000848 ATP binding site [chemical binding]; other site 234826000849 Q-loop/lid; other site 234826000850 ABC transporter signature motif; other site 234826000851 Walker B; other site 234826000852 D-loop; other site 234826000853 H-loop/switch region; other site 234826000854 metabolite-proton symporter; Region: 2A0106; TIGR00883 234826000855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000856 putative substrate translocation pore; other site 234826000857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000858 metabolite-proton symporter; Region: 2A0106; TIGR00883 234826000859 putative substrate translocation pore; other site 234826000860 NAD synthetase; Provisional; Region: PRK13981 234826000861 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 234826000862 catalytic triad [active] 234826000863 dimer interface [polypeptide binding]; other site 234826000864 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 234826000865 homodimer interface [polypeptide binding]; other site 234826000866 NAD binding pocket [chemical binding]; other site 234826000867 ATP binding pocket [chemical binding]; other site 234826000868 Mg binding site [ion binding]; other site 234826000869 active-site loop [active] 234826000870 Delta-aminolevulinic acid dehydratase; Region: ALAD; smart01004 234826000871 dimer interface [polypeptide binding]; other site 234826000872 active site 234826000873 Schiff base residues; other site 234826000874 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 234826000875 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 234826000876 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234826000877 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 234826000878 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234826000879 metabolite-proton symporter; Region: 2A0106; TIGR00883 234826000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234826000881 putative substrate translocation pore; other site 234826000882 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 234826000883 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 234826000884 dimer interface [polypeptide binding]; other site 234826000885 ssDNA binding site [nucleotide binding]; other site 234826000886 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234826000887 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 234826000888 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 234826000889 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 234826000890 GatB domain; Region: GatB_Yqey; smart00845 234826000891 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 234826000892 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 234826000893 NAD binding site [chemical binding]; other site 234826000894 homotetramer interface [polypeptide binding]; other site 234826000895 homodimer interface [polypeptide binding]; other site 234826000896 substrate binding site [chemical binding]; other site 234826000897 active site 234826000898 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 234826000899 DnaA N-terminal domain; Region: DnaA_N; pfam11638 234826000900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826000901 Walker A motif; other site 234826000902 ATP binding site [chemical binding]; other site 234826000903 Walker B motif; other site 234826000904 arginine finger; other site 234826000905 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 234826000906 DnaA box-binding interface [nucleotide binding]; other site 234826000907 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 234826000908 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 234826000909 active site 234826000910 (T/H)XGH motif; other site 234826000911 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 234826000912 active site 234826000913 hydrophilic channel; other site 234826000914 dimerization interface [polypeptide binding]; other site 234826000915 catalytic residues [active] 234826000916 active site lid [active] 234826000917 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 234826000918 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 234826000919 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 234826000920 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 234826000921 CoA-binding site [chemical binding]; other site 234826000922 ATP-binding [chemical binding]; other site 234826000923 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 234826000924 ThiC-associated domain; Region: ThiC-associated; pfam13667 234826000925 ThiC family; Region: ThiC; pfam01964 234826000926 Smr domain; Region: Smr; pfam01713 234826000927 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 234826000928 Helix-turn-helix domain; Region: HTH_37; pfam13744 234826000929 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 234826000930 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 234826000931 HIGH motif; other site 234826000932 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234826000933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826000934 active site 234826000935 KMSKS motif; other site 234826000936 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 234826000937 tRNA binding surface [nucleotide binding]; other site 234826000938 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234826000939 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 234826000940 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 234826000941 active site 234826000942 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 234826000943 active site 234826000944 dimer interface [polypeptide binding]; other site 234826000945 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 234826000946 Survival protein SurE; Region: SurE; pfam01975 234826000947 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 234826000948 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 234826000949 NADH dehydrogenase subunit B; Validated; Region: PRK06411 234826000950 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 234826000951 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 234826000952 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234826000953 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234826000954 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 234826000955 transcription antitermination factor NusB; Region: nusB; TIGR01951 234826000956 putative RNA binding site [nucleotide binding]; other site 234826000957 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 234826000958 homopentamer interface [polypeptide binding]; other site 234826000959 active site 234826000960 membrane protein insertase; Provisional; Region: PRK01318 234826000961 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 234826000962 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 234826000963 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 234826000964 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 234826000965 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 234826000966 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 234826000967 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 234826000968 FAD binding pocket [chemical binding]; other site 234826000969 FAD binding motif [chemical binding]; other site 234826000970 phosphate binding motif [ion binding]; other site 234826000971 beta-alpha-beta structure motif; other site 234826000972 NAD binding pocket [chemical binding]; other site 234826000973 Iron coordination center [ion binding]; other site 234826000974 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 234826000975 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 234826000976 active site 234826000977 homodimer interface [polypeptide binding]; other site 234826000978 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 234826000979 elongation factor P; Validated; Region: PRK00529 234826000980 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 234826000981 RNA binding site [nucleotide binding]; other site 234826000982 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 234826000983 RNA binding site [nucleotide binding]; other site 234826000984 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 234826000985 active site 234826000986 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 234826000987 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 234826000988 active site 234826000989 response regulator PleD; Reviewed; Region: pleD; PRK09581 234826000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234826000991 active site 234826000992 phosphorylation site [posttranslational modification] 234826000993 intermolecular recognition site; other site 234826000994 dimerization interface [polypeptide binding]; other site 234826000995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234826000996 active site 234826000997 phosphorylation site [posttranslational modification] 234826000998 intermolecular recognition site; other site 234826000999 dimerization interface [polypeptide binding]; other site 234826001000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234826001001 metal binding site [ion binding]; metal-binding site 234826001002 active site 234826001003 I-site; other site 234826001004 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 234826001005 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 234826001006 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 234826001007 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 234826001008 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 234826001009 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234826001010 active site 234826001011 HIGH motif; other site 234826001012 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234826001013 KMSKS motif; other site 234826001014 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234826001015 tRNA binding surface [nucleotide binding]; other site 234826001016 anticodon binding site; other site 234826001017 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 234826001018 dimer interface [polypeptide binding]; other site 234826001019 putative radical transfer pathway; other site 234826001020 diiron center [ion binding]; other site 234826001021 tyrosyl radical; other site 234826001022 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234826001023 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234826001024 catalytic residues [active] 234826001025 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 234826001026 Uncharacterized conserved protein [Function unknown]; Region: COG1565 234826001027 DNA primase; Validated; Region: dnaG; PRK05667 234826001028 CHC2 zinc finger; Region: zf-CHC2; cl17510 234826001029 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 234826001030 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 234826001031 active site 234826001032 metal binding site [ion binding]; metal-binding site 234826001033 interdomain interaction site; other site 234826001034 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 234826001035 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 234826001036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234826001037 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234826001038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234826001039 DNA binding residues [nucleotide binding] 234826001040 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 234826001041 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 234826001042 FMN binding site [chemical binding]; other site 234826001043 active site 234826001044 catalytic residues [active] 234826001045 substrate binding site [chemical binding]; other site 234826001046 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 234826001047 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 234826001048 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 234826001049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234826001050 dimer interface [polypeptide binding]; other site 234826001051 phosphorylation site [posttranslational modification] 234826001052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826001053 ATP binding site [chemical binding]; other site 234826001054 Mg2+ binding site [ion binding]; other site 234826001055 G-X-G motif; other site 234826001056 Response regulator receiver domain; Region: Response_reg; pfam00072 234826001057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234826001058 active site 234826001059 phosphorylation site [posttranslational modification] 234826001060 intermolecular recognition site; other site 234826001061 dimerization interface [polypeptide binding]; other site 234826001062 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 234826001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826001064 S-adenosylmethionine binding site [chemical binding]; other site 234826001065 2-methylcitrate dehydratase; Region: prpD; TIGR02330 234826001066 Uncharacterized conserved protein [Function unknown]; Region: COG0062 234826001067 putative carbohydrate kinase; Provisional; Region: PRK10565 234826001068 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 234826001069 putative substrate binding site [chemical binding]; other site 234826001070 putative ATP binding site [chemical binding]; other site 234826001071 DNA topoisomerase I; Validated; Region: PRK06599 234826001072 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 234826001073 active site 234826001074 interdomain interaction site; other site 234826001075 putative metal-binding site [ion binding]; other site 234826001076 nucleotide binding site [chemical binding]; other site 234826001077 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 234826001078 domain I; other site 234826001079 DNA binding groove [nucleotide binding] 234826001080 phosphate binding site [ion binding]; other site 234826001081 domain II; other site 234826001082 domain III; other site 234826001083 nucleotide binding site [chemical binding]; other site 234826001084 catalytic site [active] 234826001085 domain IV; other site 234826001086 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 234826001087 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 234826001088 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 234826001089 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 234826001090 Stringent starvation protein B; Region: SspB; pfam04386 234826001091 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14659 234826001092 prolyl-tRNA synthetase; Provisional; Region: PRK12325 234826001093 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 234826001094 dimer interface [polypeptide binding]; other site 234826001095 motif 1; other site 234826001096 active site 234826001097 motif 2; other site 234826001098 motif 3; other site 234826001099 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 234826001100 anticodon binding site; other site 234826001101 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 234826001102 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 234826001103 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 234826001104 active site 234826001105 (T/H)XGH motif; other site 234826001106 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234826001107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234826001108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234826001109 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234826001110 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 234826001111 dimer interface [polypeptide binding]; other site 234826001112 decamer (pentamer of dimers) interface [polypeptide binding]; other site 234826001113 catalytic triad [active] 234826001114 peroxidatic and resolving cysteines [active] 234826001115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234826001116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234826001117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234826001118 homodimer interface [polypeptide binding]; other site 234826001119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234826001120 catalytic residue [active] 234826001121 SurA N-terminal domain; Region: SurA_N_3; cl07813 234826001122 periplasmic folding chaperone; Provisional; Region: PRK10788 234826001123 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 234826001124 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 234826001125 Glycoprotease family; Region: Peptidase_M22; pfam00814 234826001126 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 234826001127 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234826001128 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 234826001129 rod shape-determining protein MreC; Provisional; Region: PRK13922 234826001130 rod shape-determining protein MreC; Region: MreC; pfam04085 234826001131 rod shape-determining protein MreB; Provisional; Region: PRK13927 234826001132 MreB and similar proteins; Region: MreB_like; cd10225 234826001133 nucleotide binding site [chemical binding]; other site 234826001134 Mg binding site [ion binding]; other site 234826001135 putative protofilament interaction site [polypeptide binding]; other site 234826001136 RodZ interaction site [polypeptide binding]; other site 234826001137 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 234826001138 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 234826001139 RNA binding site [nucleotide binding]; other site 234826001140 active site 234826001141 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 234826001142 16S/18S rRNA binding site [nucleotide binding]; other site 234826001143 S13e-L30e interaction site [polypeptide binding]; other site 234826001144 25S rRNA binding site [nucleotide binding]; other site 234826001145 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 234826001146 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 234826001147 oligomer interface [polypeptide binding]; other site 234826001148 RNA binding site [nucleotide binding]; other site 234826001149 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 234826001150 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 234826001151 RNase E interface [polypeptide binding]; other site 234826001152 trimer interface [polypeptide binding]; other site 234826001153 active site 234826001154 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 234826001155 putative nucleic acid binding region [nucleotide binding]; other site 234826001156 G-X-X-G motif; other site 234826001157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234826001158 RNA binding site [nucleotide binding]; other site 234826001159 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 234826001160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826001161 S-adenosylmethionine binding site [chemical binding]; other site 234826001162 GTP-binding protein LepA; Provisional; Region: PRK05433 234826001163 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 234826001164 G1 box; other site 234826001165 putative GEF interaction site [polypeptide binding]; other site 234826001166 GTP/Mg2+ binding site [chemical binding]; other site 234826001167 Switch I region; other site 234826001168 G2 box; other site 234826001169 G3 box; other site 234826001170 Switch II region; other site 234826001171 G4 box; other site 234826001172 G5 box; other site 234826001173 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 234826001174 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 234826001175 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 234826001176 Major surface protein 1a (MSP1a); Region: MSP1a; pfam11670 234826001177 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 234826001178 thiamine monophosphate kinase; Provisional; Region: PRK05731 234826001179 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 234826001180 ATP binding site [chemical binding]; other site 234826001181 dimerization interface [polypeptide binding]; other site 234826001182 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 234826001183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234826001184 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 234826001185 inhibitor-cofactor binding pocket; inhibition site 234826001186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234826001187 catalytic residue [active] 234826001188 Protein of unknown function (DUF721); Region: DUF721; pfam05258 234826001189 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 234826001190 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 234826001191 triosephosphate isomerase; Provisional; Region: PRK14565 234826001192 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 234826001193 substrate binding site [chemical binding]; other site 234826001194 dimer interface [polypeptide binding]; other site 234826001195 catalytic triad [active] 234826001196 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 234826001197 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 234826001198 UGMP family protein; Validated; Region: PRK09604 234826001199 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 234826001200 RDD family; Region: RDD; pfam06271 234826001201 Dihydroneopterin aldolase; Region: FolB; smart00905 234826001202 active site 234826001203 malate dehydrogenase; Reviewed; Region: PRK06223 234826001204 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 234826001205 NAD(P) binding site [chemical binding]; other site 234826001206 dimer interface [polypeptide binding]; other site 234826001207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234826001208 substrate binding site [chemical binding]; other site 234826001209 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 234826001210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826001211 S-adenosylmethionine binding site [chemical binding]; other site 234826001212 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 234826001213 Translation-initiation factor 2; Region: IF-2; pfam11987 234826001214 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 234826001215 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 234826001216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826001217 S-adenosylmethionine binding site [chemical binding]; other site 234826001218 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 234826001219 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 234826001220 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 234826001221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 234826001222 Phage major tail protein 2; Region: Phage_tail_2; cl11463 234826001223 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 234826001224 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 234826001225 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 234826001226 Proline dehydrogenase; Region: Pro_dh; pfam01619 234826001227 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 234826001228 Glutamate binding site [chemical binding]; other site 234826001229 NAD binding site [chemical binding]; other site 234826001230 catalytic residues [active] 234826001231 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 234826001232 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 234826001233 homotetramer interface [polypeptide binding]; other site 234826001234 NAD(P) binding site [chemical binding]; other site 234826001235 homodimer interface [polypeptide binding]; other site 234826001236 active site 234826001237 Proline dehydrogenase; Region: Pro_dh; cl03282 234826001238 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 234826001239 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 234826001240 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 234826001241 putative catalytic site [active] 234826001242 putative phosphate binding site [ion binding]; other site 234826001243 active site 234826001244 metal binding site A [ion binding]; metal-binding site 234826001245 DNA binding site [nucleotide binding] 234826001246 putative AP binding site [nucleotide binding]; other site 234826001247 putative metal binding site B [ion binding]; other site 234826001248 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 234826001249 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 234826001250 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 234826001251 enolase; Provisional; Region: eno; PRK00077 234826001252 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 234826001253 dimer interface [polypeptide binding]; other site 234826001254 metal binding site [ion binding]; metal-binding site 234826001255 substrate binding pocket [chemical binding]; other site 234826001256 GTPase CgtA; Reviewed; Region: obgE; PRK12299 234826001257 GTP1/OBG; Region: GTP1_OBG; pfam01018 234826001258 Obg GTPase; Region: Obg; cd01898 234826001259 G1 box; other site 234826001260 GTP/Mg2+ binding site [chemical binding]; other site 234826001261 Switch I region; other site 234826001262 G2 box; other site 234826001263 G3 box; other site 234826001264 Switch II region; other site 234826001265 G4 box; other site 234826001266 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 234826001267 MraW methylase family; Region: Methyltransf_5; cl17771 234826001268 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 234826001269 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 234826001270 nuclear-egress-membrane-like protein; Provisional; Region: PHA03325 234826001271 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 234826001272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234826001273 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 234826001274 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 234826001275 GTP cyclohydrolase I; Provisional; Region: PLN03044 234826001276 active site 234826001277 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 234826001278 core domain interface [polypeptide binding]; other site 234826001279 delta subunit interface [polypeptide binding]; other site 234826001280 epsilon subunit interface [polypeptide binding]; other site 234826001281 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 234826001282 NADH dehydrogenase subunit D; Validated; Region: PRK06075 234826001283 NADH dehydrogenase subunit E; Validated; Region: PRK07539 234826001284 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 234826001285 putative dimer interface [polypeptide binding]; other site 234826001286 [2Fe-2S] cluster binding site [ion binding]; other site 234826001287 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 234826001288 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 234826001289 active site 234826001290 catalytic site [active] 234826001291 substrate binding site [chemical binding]; other site 234826001292 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 234826001293 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 234826001294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826001295 Walker A motif; other site 234826001296 ATP binding site [chemical binding]; other site 234826001297 Walker B motif; other site 234826001298 arginine finger; other site 234826001299 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 234826001300 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 234826001301 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 234826001302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234826001303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234826001304 DNA binding residues [nucleotide binding] 234826001305 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 234826001306 30S subunit binding site; other site 234826001307 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001308 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 234826001309 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001310 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001311 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234826001312 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 234826001313 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 234826001314 NADH dehydrogenase subunit G; Validated; Region: PRK09130 234826001315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234826001316 catalytic loop [active] 234826001317 iron binding site [ion binding]; other site 234826001318 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 234826001319 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 234826001320 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 234826001321 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 234826001322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234826001323 Mg2+ binding site [ion binding]; other site 234826001324 G-X-G motif; other site 234826001325 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 234826001326 anchoring element; other site 234826001327 dimer interface [polypeptide binding]; other site 234826001328 ATP binding site [chemical binding]; other site 234826001329 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 234826001330 active site 234826001331 putative metal-binding site [ion binding]; other site 234826001332 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 234826001333 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 234826001334 Flavoprotein; Region: Flavoprotein; pfam02441 234826001335 Cytochrome C biogenesis protein; Region: CcmH; cl01179 234826001336 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 234826001337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234826001338 catalytic loop [active] 234826001339 iron binding site [ion binding]; other site 234826001340 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 234826001341 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 234826001342 nucleotide binding site [chemical binding]; other site 234826001343 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234826001344 SBD interface [polypeptide binding]; other site 234826001345 co-chaperone HscB; Provisional; Region: hscB; PRK05014 234826001346 DnaJ domain; Region: DnaJ; pfam00226 234826001347 HSP70 interaction site [polypeptide binding]; other site 234826001348 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 234826001349 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 234826001350 trimerization site [polypeptide binding]; other site 234826001351 active site 234826001352 cysteine desulfurase; Provisional; Region: PRK14012 234826001353 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 234826001354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234826001355 catalytic residue [active] 234826001356 Transcriptional regulator; Region: Rrf2; cl17282 234826001357 Rrf2 family protein; Region: rrf2_super; TIGR00738 234826001358 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 234826001359 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 234826001360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234826001361 catalytic residue [active] 234826001362 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 234826001363 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 234826001364 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826001365 active site 234826001366 nucleotide binding site [chemical binding]; other site 234826001367 HIGH motif; other site 234826001368 KMSKS motif; other site 234826001369 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 234826001370 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 234826001371 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 234826001372 dimerization interface 3.5A [polypeptide binding]; other site 234826001373 active site 234826001374 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 234826001375 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234826001376 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234826001377 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 234826001378 active site 234826001379 intersubunit interactions; other site 234826001380 catalytic residue [active] 234826001381 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 234826001382 gamma subunit interface [polypeptide binding]; other site 234826001383 epsilon subunit interface [polypeptide binding]; other site 234826001384 LBP interface [polypeptide binding]; other site 234826001385 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 234826001386 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234826001387 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 234826001388 alpha subunit interaction interface [polypeptide binding]; other site 234826001389 Walker A motif; other site 234826001390 ATP binding site [chemical binding]; other site 234826001391 Walker B motif; other site 234826001392 inhibitor binding site; inhibition site 234826001393 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234826001394 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 234826001395 MgtE intracellular N domain; Region: MgtE_N; smart00924 234826001396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 234826001397 Divalent cation transporter; Region: MgtE; cl00786 234826001398 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 234826001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826001400 S-adenosylmethionine binding site [chemical binding]; other site 234826001401 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 234826001402 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 234826001403 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 234826001404 active site 234826001405 HIGH motif; other site 234826001406 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826001407 KMSK motif region; other site 234826001408 tRNA binding surface [nucleotide binding]; other site 234826001409 DALR anticodon binding domain; Region: DALR_1; smart00836 234826001410 anticodon binding site; other site 234826001411 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 234826001412 Recombination protein O C terminal; Region: RecO_C; pfam02565 234826001413 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 234826001414 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 234826001415 HIGH motif; other site 234826001416 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 234826001417 active site 234826001418 KMSKS motif; other site 234826001419 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 234826001420 tRNA binding surface [nucleotide binding]; other site 234826001421 anticodon binding site; other site 234826001422 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234826001423 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234826001424 catalytic triad [active] 234826001425 RNA methyltransferase, RsmE family; Region: TIGR00046 234826001426 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 234826001427 peptide chain release factor 2; Validated; Region: prfB; PRK00578 234826001428 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234826001429 RF-1 domain; Region: RF-1; pfam00472 234826001430 hypothetical protein; Validated; Region: PRK00110 234826001431 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234826001432 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 234826001433 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 234826001434 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 234826001435 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 234826001436 domain interfaces; other site 234826001437 active site 234826001438 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 234826001439 FAD binding domain; Region: FAD_binding_4; pfam01565 234826001440 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 234826001441 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001442 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234826001443 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001444 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001445 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001446 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234826001447 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234826001448 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001449 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001450 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 234826001451 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001452 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234826001453 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 234826001454 4Fe-4S binding domain; Region: Fer4; cl02805 234826001455 4Fe-4S binding domain; Region: Fer4; pfam00037 234826001456 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234826001457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234826001458 Catalytic site [active] 234826001459 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234826001460 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 234826001461 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826001462 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826001463 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 234826001464 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 234826001465 G1 box; other site 234826001466 putative GEF interaction site [polypeptide binding]; other site 234826001467 GTP/Mg2+ binding site [chemical binding]; other site 234826001468 Switch I region; other site 234826001469 G2 box; other site 234826001470 G3 box; other site 234826001471 Switch II region; other site 234826001472 G4 box; other site 234826001473 G5 box; other site 234826001474 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 234826001475 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 234826001476 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 234826001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826001478 Walker A motif; other site 234826001479 ATP binding site [chemical binding]; other site 234826001480 Walker B motif; other site 234826001481 arginine finger; other site 234826001482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826001483 Walker A motif; other site 234826001484 ATP binding site [chemical binding]; other site 234826001485 Walker B motif; other site 234826001486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234826001487 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 234826001488 Ribosome-binding factor A; Region: RBFA; pfam02033 234826001489 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234826001490 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 234826001491 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 234826001492 G1 box; other site 234826001493 putative GEF interaction site [polypeptide binding]; other site 234826001494 GTP/Mg2+ binding site [chemical binding]; other site 234826001495 Switch I region; other site 234826001496 G2 box; other site 234826001497 G3 box; other site 234826001498 Switch II region; other site 234826001499 G4 box; other site 234826001500 G5 box; other site 234826001501 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 234826001502 Translation-initiation factor 2; Region: IF-2; pfam11987 234826001503 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 234826001504 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 234826001505 NusA N-terminal domain; Region: NusA_N; pfam08529 234826001506 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 234826001507 RNA binding site [nucleotide binding]; other site 234826001508 homodimer interface [polypeptide binding]; other site 234826001509 NusA-like KH domain; Region: KH_5; pfam13184 234826001510 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 234826001511 G-X-X-G motif; other site 234826001512 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 234826001513 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 234826001514 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 234826001515 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 234826001516 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234826001517 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234826001518 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 234826001519 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 234826001520 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 234826001521 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 234826001522 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 234826001523 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826001524 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 234826001525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826001526 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 234826001527 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 234826001528 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826001529 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 234826001530 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 234826001531 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 234826001532 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 234826001533 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 234826001534 SLBB domain; Region: SLBB; pfam10531 234826001535 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 234826001536 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 234826001537 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 234826001538 VirB8 protein; Region: VirB8; cl01500 234826001539 RmuC family; Region: RmuC; pfam02646 234826001540 seryl-tRNA synthetase; Provisional; Region: PRK05431 234826001541 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 234826001542 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 234826001543 dimer interface [polypeptide binding]; other site 234826001544 active site 234826001545 motif 1; other site 234826001546 motif 2; other site 234826001547 motif 3; other site 234826001548 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 234826001549 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 234826001550 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 234826001551 feedback inhibition sensing region; other site 234826001552 homohexameric interface [polypeptide binding]; other site 234826001553 nucleotide binding site [chemical binding]; other site 234826001554 N-acetyl-L-glutamate binding site [chemical binding]; other site 234826001555 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 234826001556 G1 box; other site 234826001557 GTP/Mg2+ binding site [chemical binding]; other site 234826001558 Switch I region; other site 234826001559 G2 box; other site 234826001560 G3 box; other site 234826001561 Switch II region; other site 234826001562 G4 box; other site 234826001563 G5 box; other site 234826001564 peptide chain release factor 1; Validated; Region: prfA; PRK00591 234826001565 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234826001566 RF-1 domain; Region: RF-1; pfam00472 234826001567 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234826001568 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234826001569 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234826001570 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 234826001571 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 234826001572 DNA binding site [nucleotide binding] 234826001573 catalytic residue [active] 234826001574 H2TH interface [polypeptide binding]; other site 234826001575 putative catalytic residues [active] 234826001576 turnover-facilitating residue; other site 234826001577 intercalation triad [nucleotide binding]; other site 234826001578 8OG recognition residue [nucleotide binding]; other site 234826001579 putative reading head residues; other site 234826001580 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234826001581 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234826001582 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 234826001583 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234826001584 active site 234826001585 HIGH motif; other site 234826001586 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234826001587 active site 234826001588 KMSKS motif; other site 234826001589 Protein of unknown function (DUF2861); Region: DUF2861; pfam11060 234826001590 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 234826001591 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234826001592 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 234826001593 Qi binding site; other site 234826001594 intrachain domain interface; other site 234826001595 interchain domain interface [polypeptide binding]; other site 234826001596 cytochrome b; Provisional; Region: CYTB; MTH00156 234826001597 heme bH binding site [chemical binding]; other site 234826001598 heme bL binding site [chemical binding]; other site 234826001599 Qo binding site; other site 234826001600 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 234826001601 interchain domain interface [polypeptide binding]; other site 234826001602 intrachain domain interface; other site 234826001603 Qi binding site; other site 234826001604 Qo binding site; other site 234826001605 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 234826001606 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 234826001607 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 234826001608 [2Fe-2S] cluster binding site [ion binding]; other site 234826001609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 234826001610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234826001611 ABC-ATPase subunit interface; other site 234826001612 dimer interface [polypeptide binding]; other site 234826001613 putative PBP binding regions; other site 234826001614 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 234826001615 elongation factor Ts; Provisional; Region: tsf; PRK09377 234826001616 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 234826001617 Elongation factor TS; Region: EF_TS; pfam00889 234826001618 Elongation factor TS; Region: EF_TS; pfam00889 234826001619 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 234826001620 rRNA interaction site [nucleotide binding]; other site 234826001621 S8 interaction site; other site 234826001622 putative laminin-1 binding site; other site 234826001623 Maf-like protein; Region: Maf; pfam02545 234826001624 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 234826001625 active site 234826001626 dimer interface [polypeptide binding]; other site 234826001627 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 234826001628 rRNA binding site [nucleotide binding]; other site 234826001629 predicted 30S ribosome binding site; other site 234826001630 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 234826001631 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 234826001632 HlyD family secretion protein; Region: HlyD_3; pfam13437 234826001633 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 234826001634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234826001635 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234826001636 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 234826001637 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234826001638 PQQ-like domain; Region: PQQ_2; pfam13360 234826001639 Trp docking motif [polypeptide binding]; other site 234826001640 active site 234826001641 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 234826001642 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 234826001643 G1 box; other site 234826001644 GTP/Mg2+ binding site [chemical binding]; other site 234826001645 Switch I region; other site 234826001646 G2 box; other site 234826001647 Switch II region; other site 234826001648 G3 box; other site 234826001649 G4 box; other site 234826001650 G5 box; other site 234826001651 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 234826001652 G1 box; other site 234826001653 GTP/Mg2+ binding site [chemical binding]; other site 234826001654 Switch I region; other site 234826001655 G2 box; other site 234826001656 G3 box; other site 234826001657 Switch II region; other site 234826001658 G4 box; other site 234826001659 G5 box; other site 234826001660 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 234826001661 phosphoglyceromutase; Provisional; Region: PRK05434 234826001662 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 234826001663 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 234826001664 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 234826001665 catalytic site [active] 234826001666 subunit interface [polypeptide binding]; other site 234826001667 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 234826001668 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 234826001669 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 234826001670 trimer interface [polypeptide binding]; other site 234826001671 active site 234826001672 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 234826001673 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234826001674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234826001675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234826001676 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 234826001677 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 234826001678 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 234826001679 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 234826001680 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 234826001681 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 234826001682 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 234826001683 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 234826001684 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 234826001685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826001686 Walker A/P-loop; other site 234826001687 ATP binding site [chemical binding]; other site 234826001688 Q-loop/lid; other site 234826001689 type IV secretion system protein VirB3; Provisional; Region: PRK13899 234826001690 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 234826001691 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 234826001692 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 234826001693 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 234826001694 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 234826001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234826001696 dimer interface [polypeptide binding]; other site 234826001697 conserved gate region; other site 234826001698 putative PBP binding loops; other site 234826001699 ABC-ATPase subunit interface; other site 234826001700 lipoyl synthase; Provisional; Region: PRK05481 234826001701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234826001702 FeS/SAM binding site; other site 234826001703 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 234826001704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234826001705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234826001706 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234826001707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234826001708 carboxyltransferase (CT) interaction site; other site 234826001709 biotinylation site [posttranslational modification]; other site 234826001710 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 234826001711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234826001712 RNA binding surface [nucleotide binding]; other site 234826001713 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 234826001714 active site 234826001715 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 234826001716 primosome assembly protein PriA; Validated; Region: PRK05580 234826001717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234826001718 ATP binding site [chemical binding]; other site 234826001719 putative Mg++ binding site [ion binding]; other site 234826001720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234826001721 nucleotide binding region [chemical binding]; other site 234826001722 ATP-binding site [chemical binding]; other site 234826001723 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 234826001724 conserved cys residue [active] 234826001725 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 234826001726 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234826001727 active site 234826001728 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234826001729 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234826001730 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 234826001731 active site 234826001732 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 234826001733 catalytic motif [active] 234826001734 Catalytic residue [active] 234826001735 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 234826001736 active site 234826001737 catalytic site [active] 234826001738 substrate binding site [chemical binding]; other site 234826001739 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 234826001740 GTPase Era; Reviewed; Region: era; PRK00089 234826001741 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 234826001742 G1 box; other site 234826001743 GTP/Mg2+ binding site [chemical binding]; other site 234826001744 Switch I region; other site 234826001745 G2 box; other site 234826001746 Switch II region; other site 234826001747 G3 box; other site 234826001748 G4 box; other site 234826001749 G5 box; other site 234826001750 KH domain; Region: KH_2; pfam07650 234826001751 signal recognition particle protein; Provisional; Region: PRK10867 234826001752 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 234826001753 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 234826001754 P loop; other site 234826001755 GTP binding site [chemical binding]; other site 234826001756 Signal peptide binding domain; Region: SRP_SPB; pfam02978 234826001757 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12664 234826001758 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234826001759 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 234826001760 putative coenzyme Q binding site [chemical binding]; other site 234826001761 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 234826001762 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234826001763 nucleotide binding site [chemical binding]; other site 234826001764 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234826001765 RNA binding site [nucleotide binding]; other site 234826001766 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234826001767 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 234826001768 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 234826001769 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 234826001770 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 234826001771 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 234826001772 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 234826001773 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12670 234826001774 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12603 234826001775 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 234826001776 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234826001777 TPP-binding site [chemical binding]; other site 234826001778 dimer interface [polypeptide binding]; other site 234826001779 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234826001780 PYR/PP interface [polypeptide binding]; other site 234826001781 dimer interface [polypeptide binding]; other site 234826001782 TPP binding site [chemical binding]; other site 234826001783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234826001784 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 234826001785 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 234826001786 Zn binding site [ion binding]; other site 234826001787 putative outer membrane lipoprotein; Provisional; Region: PRK09967 234826001788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 234826001789 ligand binding site [chemical binding]; other site 234826001790 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 234826001791 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 234826001792 GDP-binding site [chemical binding]; other site 234826001793 ACT binding site; other site 234826001794 IMP binding site; other site 234826001795 GTPase CgtA; Reviewed; Region: obgE; PRK12299 234826001796 GTP1/OBG; Region: GTP1_OBG; pfam01018 234826001797 Obg GTPase; Region: Obg; cd01898 234826001798 G1 box; other site 234826001799 GTP/Mg2+ binding site [chemical binding]; other site 234826001800 Switch I region; other site 234826001801 G2 box; other site 234826001802 G3 box; other site 234826001803 Switch II region; other site 234826001804 G4 box; other site 234826001805 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 234826001806 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 234826001807 Class I ribonucleotide reductase; Region: RNR_I; cd01679 234826001808 active site 234826001809 dimer interface [polypeptide binding]; other site 234826001810 catalytic residues [active] 234826001811 effector binding site; other site 234826001812 R2 peptide binding site; other site 234826001813 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234826001814 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234826001815 substrate binding pocket [chemical binding]; other site 234826001816 chain length determination region; other site 234826001817 substrate-Mg2+ binding site; other site 234826001818 catalytic residues [active] 234826001819 aspartate-rich region 1; other site 234826001820 active site lid residues [active] 234826001821 aspartate-rich region 2; other site 234826001822 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234826001823 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 234826001824 replicative DNA helicase; Provisional; Region: PRK09165 234826001825 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 234826001826 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 234826001827 Walker A motif; other site 234826001828 ATP binding site [chemical binding]; other site 234826001829 Walker B motif; other site 234826001830 DNA binding loops [nucleotide binding] 234826001831 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234826001832 nucleoside/Zn binding site; other site 234826001833 dimer interface [polypeptide binding]; other site 234826001834 catalytic motif [active] 234826001835 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 234826001836 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 234826001837 dimer interface [polypeptide binding]; other site 234826001838 active site 234826001839 CoA binding pocket [chemical binding]; other site 234826001840 putative phosphate acyltransferase; Provisional; Region: PRK05331 234826001841 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 234826001842 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 234826001843 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 234826001844 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14244 234826001845 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 234826001846 Walker A/P-loop; other site 234826001847 ATP binding site [chemical binding]; other site 234826001848 Q-loop/lid; other site 234826001849 ABC transporter signature motif; other site 234826001850 Walker B; other site 234826001851 D-loop; other site 234826001852 H-loop/switch region; other site 234826001853 dihydrodipicolinate reductase; Provisional; Region: PRK00048 234826001854 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 234826001855 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 234826001856 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234826001857 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 234826001858 UbiA prenyltransferase family; Region: UbiA; pfam01040 234826001859 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 234826001860 Ribonuclease P; Region: Ribonuclease_P; pfam00825 234826001861 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 234826001862 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 234826001863 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 234826001864 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 234826001865 Competence protein; Region: Competence; pfam03772 234826001866 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 234826001867 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 234826001868 putative tRNA-binding site [nucleotide binding]; other site 234826001869 B3/4 domain; Region: B3_4; pfam03483 234826001870 tRNA synthetase B5 domain; Region: B5; smart00874 234826001871 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 234826001872 dimer interface [polypeptide binding]; other site 234826001873 motif 1; other site 234826001874 motif 3; other site 234826001875 motif 2; other site 234826001876 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 234826001877 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 234826001878 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 234826001879 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 234826001880 alphaNTD - beta interaction site [polypeptide binding]; other site 234826001881 alphaNTD homodimer interface [polypeptide binding]; other site 234826001882 alphaNTD - beta' interaction site [polypeptide binding]; other site 234826001883 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 234826001884 30S ribosomal protein S11; Validated; Region: PRK05309 234826001885 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 234826001886 30S ribosomal protein S13; Region: bact_S13; TIGR03631 234826001887 adenylate kinase; Region: adk; TIGR01351 234826001888 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 234826001889 AMP-binding site [chemical binding]; other site 234826001890 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 234826001891 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 234826001892 SecY translocase; Region: SecY; pfam00344 234826001893 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 234826001894 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 234826001895 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 234826001896 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 234826001897 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 234826001898 5S rRNA interface [nucleotide binding]; other site 234826001899 23S rRNA interface [nucleotide binding]; other site 234826001900 L5 interface [polypeptide binding]; other site 234826001901 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 234826001902 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234826001903 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234826001904 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 234826001905 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 234826001906 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 234826001907 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 234826001908 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 234826001909 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 234826001910 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 234826001911 RNA binding site [nucleotide binding]; other site 234826001912 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 234826001913 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 234826001914 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 234826001915 putative translocon interaction site; other site 234826001916 23S rRNA interface [nucleotide binding]; other site 234826001917 signal recognition particle (SRP54) interaction site; other site 234826001918 L23 interface [polypeptide binding]; other site 234826001919 trigger factor interaction site; other site 234826001920 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 234826001921 23S rRNA interface [nucleotide binding]; other site 234826001922 5S rRNA interface [nucleotide binding]; other site 234826001923 putative antibiotic binding site [chemical binding]; other site 234826001924 L25 interface [polypeptide binding]; other site 234826001925 L27 interface [polypeptide binding]; other site 234826001926 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 234826001927 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 234826001928 G-X-X-G motif; other site 234826001929 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 234826001930 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 234826001931 putative translocon binding site; other site 234826001932 protein-rRNA interface [nucleotide binding]; other site 234826001933 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 234826001934 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 234826001935 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 234826001936 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 234826001937 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 234826001938 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 234826001939 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 234826001940 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 234826001941 elongation factor Tu; Reviewed; Region: PRK00049 234826001942 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 234826001943 G1 box; other site 234826001944 GEF interaction site [polypeptide binding]; other site 234826001945 GTP/Mg2+ binding site [chemical binding]; other site 234826001946 Switch I region; other site 234826001947 G2 box; other site 234826001948 G3 box; other site 234826001949 Switch II region; other site 234826001950 G4 box; other site 234826001951 G5 box; other site 234826001952 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 234826001953 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 234826001954 Antibiotic Binding Site [chemical binding]; other site 234826001955 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 234826001956 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 234826001957 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234826001958 cytidylate kinase; Provisional; Region: cmk; PRK00023 234826001959 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 234826001960 CMP-binding site; other site 234826001961 The sites determining sugar specificity; other site 234826001962 ribosomal protein S1; Region: rpsA; TIGR00717 234826001963 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 234826001964 RNA binding site [nucleotide binding]; other site 234826001965 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 234826001966 RNA binding site [nucleotide binding]; other site 234826001967 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 234826001968 RNA binding site [nucleotide binding]; other site 234826001969 S1 RNA binding domain; Region: S1; pfam00575 234826001970 RNA binding site [nucleotide binding]; other site 234826001971 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234826001972 RNA binding site [nucleotide binding]; other site 234826001973 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 234826001974 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 234826001975 tandem repeat interface [polypeptide binding]; other site 234826001976 oligomer interface [polypeptide binding]; other site 234826001977 active site residues [active] 234826001978 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 234826001979 Cell division protein ZapA; Region: ZapA; pfam05164 234826001980 ferrochelatase; Reviewed; Region: hemH; PRK00035 234826001981 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 234826001982 C-terminal domain interface [polypeptide binding]; other site 234826001983 active site 234826001984 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 234826001985 active site 234826001986 N-terminal domain interface [polypeptide binding]; other site 234826001987 Predicted ATPase [General function prediction only]; Region: COG1485 234826001988 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234826001989 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 234826001990 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234826001991 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234826001992 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234826001993 Part of AAA domain; Region: AAA_19; pfam13245 234826001994 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 234826001995 Family description; Region: UvrD_C_2; pfam13538 234826001996 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 234826001997 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 234826001998 NADP binding site [chemical binding]; other site 234826001999 dimer interface [polypeptide binding]; other site 234826002000 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 234826002001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234826002002 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 234826002003 Walker A/P-loop; other site 234826002004 ATP binding site [chemical binding]; other site 234826002005 Q-loop/lid; other site 234826002006 ABC transporter signature motif; other site 234826002007 Walker B; other site 234826002008 D-loop; other site 234826002009 H-loop/switch region; other site 234826002010 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 234826002011 dihydropteroate synthase; Region: DHPS; TIGR01496 234826002012 substrate binding pocket [chemical binding]; other site 234826002013 dimer interface [polypeptide binding]; other site 234826002014 inhibitor binding site; inhibition site 234826002015 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 234826002016 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234826002017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234826002018 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 234826002019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234826002020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234826002021 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 234826002022 IMP binding site; other site 234826002023 dimer interface [polypeptide binding]; other site 234826002024 interdomain contacts; other site 234826002025 partial ornithine binding site; other site 234826002026 fumarate hydratase; Reviewed; Region: fumC; PRK00485 234826002027 Class II fumarases; Region: Fumarase_classII; cd01362 234826002028 active site 234826002029 tetramer interface [polypeptide binding]; other site 234826002030 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 234826002031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234826002032 dihydroorotase; Validated; Region: pyrC; PRK09357 234826002033 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 234826002034 active site 234826002035 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 234826002036 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 234826002037 active site 234826002038 substrate binding site [chemical binding]; other site 234826002039 metal binding site [ion binding]; metal-binding site 234826002040 lipoate-protein ligase B; Provisional; Region: PRK14341 234826002041 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 234826002042 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 234826002043 MPN+ (JAMM) motif; other site 234826002044 Zinc-binding site [ion binding]; other site 234826002045 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 234826002046 oligomerisation interface [polypeptide binding]; other site 234826002047 mobile loop; other site 234826002048 roof hairpin; other site 234826002049 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 234826002050 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 234826002051 ring oligomerisation interface [polypeptide binding]; other site 234826002052 ATP/Mg binding site [chemical binding]; other site 234826002053 stacking interactions; other site 234826002054 hinge regions; other site 234826002055 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234826002056 classical (c) SDRs; Region: SDR_c; cd05233 234826002057 NAD(P) binding site [chemical binding]; other site 234826002058 active site 234826002059 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 234826002060 Clp amino terminal domain; Region: Clp_N; pfam02861 234826002061 Clp amino terminal domain; Region: Clp_N; pfam02861 234826002062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826002063 Walker A motif; other site 234826002064 ATP binding site [chemical binding]; other site 234826002065 Walker B motif; other site 234826002066 arginine finger; other site 234826002067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826002068 Walker A motif; other site 234826002069 ATP binding site [chemical binding]; other site 234826002070 Walker B motif; other site 234826002071 arginine finger; other site 234826002072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234826002073 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 234826002074 multifunctional aminopeptidase A; Provisional; Region: PRK00913 234826002075 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 234826002076 interface (dimer of trimers) [polypeptide binding]; other site 234826002077 Substrate-binding/catalytic site; other site 234826002078 Zn-binding sites [ion binding]; other site 234826002079 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 234826002080 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 234826002081 active site 234826002082 substrate binding site [chemical binding]; other site 234826002083 cosubstrate binding site; other site 234826002084 catalytic site [active] 234826002085 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 234826002086 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 234826002087 putative active site [active] 234826002088 catalytic triad [active] 234826002089 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 234826002090 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 234826002091 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 234826002092 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 234826002093 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 234826002094 putative active site [active] 234826002095 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234826002096 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234826002097 E3 interaction surface; other site 234826002098 lipoyl attachment site [posttranslational modification]; other site 234826002099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 234826002100 biotin synthase; Region: bioB; TIGR00433 234826002101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234826002102 FeS/SAM binding site; other site 234826002103 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 234826002104 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 234826002105 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 234826002106 dimerization interface [polypeptide binding]; other site 234826002107 ATP binding site [chemical binding]; other site 234826002108 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 234826002109 dimerization interface [polypeptide binding]; other site 234826002110 ATP binding site [chemical binding]; other site 234826002111 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 234826002112 catalytic center binding site [active] 234826002113 ATP binding site [chemical binding]; other site 234826002114 Peptidase family M48; Region: Peptidase_M48; cl12018 234826002115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 234826002116 binding surface 234826002117 TPR motif; other site 234826002118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234826002119 TPR motif; other site 234826002120 binding surface 234826002121 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 234826002122 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 234826002123 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 234826002124 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 234826002125 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 234826002126 dimerization interface [polypeptide binding]; other site 234826002127 putative ATP binding site [chemical binding]; other site 234826002128 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234826002129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234826002130 active site 234826002131 DNA binding site [nucleotide binding] 234826002132 Int/Topo IB signature motif; other site 234826002133 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234826002134 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14620 234826002135 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 234826002136 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002137 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002138 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002139 transcription termination factor Rho; Provisional; Region: rho; PRK09376 234826002140 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 234826002141 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 234826002142 RNA binding site [nucleotide binding]; other site 234826002143 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 234826002144 multimer interface [polypeptide binding]; other site 234826002145 Walker A motif; other site 234826002146 ATP binding site [chemical binding]; other site 234826002147 Walker B motif; other site 234826002148 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 234826002149 active site 234826002150 HslU subunit interaction site [polypeptide binding]; other site 234826002151 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 234826002152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826002153 Walker A motif; other site 234826002154 ATP binding site [chemical binding]; other site 234826002155 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 234826002156 Walker B motif; other site 234826002157 arginine finger; other site 234826002158 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234826002159 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 234826002160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826002161 S-adenosylmethionine binding site [chemical binding]; other site 234826002162 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 234826002163 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826002164 active site 234826002165 KMSKS motif; other site 234826002166 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 234826002167 tRNA binding surface [nucleotide binding]; other site 234826002168 anticodon binding site; other site 234826002169 aspartate kinase; Reviewed; Region: PRK06635 234826002170 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 234826002171 putative nucleotide binding site [chemical binding]; other site 234826002172 putative catalytic residues [active] 234826002173 putative Mg ion binding site [ion binding]; other site 234826002174 putative aspartate binding site [chemical binding]; other site 234826002175 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 234826002176 putative allosteric regulatory site; other site 234826002177 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 234826002178 putative allosteric regulatory residue; other site 234826002179 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 234826002180 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00117 234826002181 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234826002182 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234826002183 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 234826002184 Subunit I/III interface [polypeptide binding]; other site 234826002185 D-pathway; other site 234826002186 Subunit I/VIIc interface [polypeptide binding]; other site 234826002187 Subunit I/IV interface [polypeptide binding]; other site 234826002188 Subunit I/II interface [polypeptide binding]; other site 234826002189 Low-spin heme (heme a) binding site [chemical binding]; other site 234826002190 Subunit I/VIIa interface [polypeptide binding]; other site 234826002191 Subunit I/VIa interface [polypeptide binding]; other site 234826002192 Dimer interface; other site 234826002193 Putative water exit pathway; other site 234826002194 Binuclear center (heme a3/CuB) [ion binding]; other site 234826002195 K-pathway; other site 234826002196 Subunit I/Vb interface [polypeptide binding]; other site 234826002197 Putative proton exit pathway; other site 234826002198 Subunit I/VIb interface; other site 234826002199 Subunit I/VIc interface [polypeptide binding]; other site 234826002200 Electron transfer pathway; other site 234826002201 Subunit I/VIIIb interface [polypeptide binding]; other site 234826002202 Subunit I/VIIb interface [polypeptide binding]; other site 234826002203 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 234826002204 UbiA prenyltransferase family; Region: UbiA; pfam01040 234826002205 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 234826002206 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 234826002207 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 234826002208 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 234826002209 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 234826002210 Preprotein translocase subunit; Region: YajC; pfam02699 234826002211 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 234826002212 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 234826002213 glutaminase active site [active] 234826002214 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 234826002215 dimer interface [polypeptide binding]; other site 234826002216 active site 234826002217 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 234826002218 dimer interface [polypeptide binding]; other site 234826002219 active site 234826002220 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 234826002221 DNA polymerase III subunit beta; Validated; Region: PRK05643 234826002222 putative DNA binding surface [nucleotide binding]; other site 234826002223 dimer interface [polypeptide binding]; other site 234826002224 beta-clamp/clamp loader binding surface; other site 234826002225 beta-clamp/translesion DNA polymerase binding surface; other site 234826002226 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 234826002227 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 234826002228 catalytic site [active] 234826002229 putative active site [active] 234826002230 putative substrate binding site [chemical binding]; other site 234826002231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234826002232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234826002233 active site 234826002234 phosphorylation site [posttranslational modification] 234826002235 intermolecular recognition site; other site 234826002236 dimerization interface [polypeptide binding]; other site 234826002237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234826002238 DNA binding site [nucleotide binding] 234826002239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234826002240 non-specific DNA binding site [nucleotide binding]; other site 234826002241 salt bridge; other site 234826002242 Predicted transcriptional regulator [Transcription]; Region: COG2932 234826002243 sequence-specific DNA binding site [nucleotide binding]; other site 234826002244 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 234826002245 Catalytic site [active] 234826002246 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 234826002247 dimer interface [polypeptide binding]; other site 234826002248 substrate binding site [chemical binding]; other site 234826002249 metal binding sites [ion binding]; metal-binding site 234826002250 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 234826002251 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 234826002252 23S rRNA interface [nucleotide binding]; other site 234826002253 L3 interface [polypeptide binding]; other site 234826002254 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 234826002255 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 234826002256 Domain of unknown function DUF59; Region: DUF59; pfam01883 234826002257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 234826002258 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 234826002259 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 234826002260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234826002261 active site 234826002262 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686 234826002263 aconitate hydratase; Validated; Region: PRK09277 234826002264 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 234826002265 substrate binding site [chemical binding]; other site 234826002266 ligand binding site [chemical binding]; other site 234826002267 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 234826002268 substrate binding site [chemical binding]; other site 234826002269 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 234826002270 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 234826002271 ATP-grasp domain; Region: ATP-grasp; pfam02222 234826002272 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 234826002273 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 234826002274 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002275 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002276 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002277 TrbC/VIRB2 family; Region: TrbC; cl01583 234826002278 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002279 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002280 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002281 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 234826002282 HflK protein; Region: hflK; TIGR01933 234826002283 HflC protein; Region: hflC; TIGR01932 234826002284 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 234826002285 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 234826002286 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234826002287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234826002288 protein binding site [polypeptide binding]; other site 234826002289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234826002290 protein binding site [polypeptide binding]; other site 234826002291 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 234826002292 ribonuclease III; Reviewed; Region: rnc; PRK00102 234826002293 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 234826002294 dimerization interface [polypeptide binding]; other site 234826002295 active site 234826002296 metal binding site [ion binding]; metal-binding site 234826002297 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 234826002298 dsRNA binding site [nucleotide binding]; other site 234826002299 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 234826002300 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234826002301 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234826002302 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234826002303 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234826002304 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234826002305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234826002306 lipoprotein signal peptidase; Provisional; Region: PRK14775 234826002307 lipoprotein signal peptidase; Provisional; Region: PRK14787 234826002308 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 234826002309 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 234826002310 active site 234826002311 Riboflavin kinase; Region: Flavokinase; smart00904 234826002312 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 234826002313 GSH binding site [chemical binding]; other site 234826002314 catalytic residues [active] 234826002315 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 234826002316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826002317 S-adenosylmethionine binding site [chemical binding]; other site 234826002318 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234826002319 active site 234826002320 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 234826002321 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234826002322 E3 interaction surface; other site 234826002323 lipoyl attachment site [posttranslational modification]; other site 234826002324 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234826002325 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 234826002326 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 234826002327 trimer interface [polypeptide binding]; other site 234826002328 putative metal binding site [ion binding]; other site 234826002329 pantoate--beta-alanine ligase; Region: panC; TIGR00018 234826002330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826002331 active site 234826002332 nucleotide binding site [chemical binding]; other site 234826002333 HIGH motif; other site 234826002334 KMSKS motif; other site 234826002335 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 234826002336 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 234826002337 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 234826002338 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 234826002339 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 234826002340 DsbD alpha interface [polypeptide binding]; other site 234826002341 catalytic residues [active] 234826002342 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 234826002343 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 234826002344 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 234826002345 active site 234826002346 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 234826002347 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 234826002348 putative substrate binding region [chemical binding]; other site 234826002349 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 234826002350 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234826002351 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234826002352 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234826002353 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 234826002354 Surface antigen; Region: Bac_surface_Ag; pfam01103 234826002355 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 234826002356 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 234826002357 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 234826002358 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 234826002359 purine monophosphate binding site [chemical binding]; other site 234826002360 dimer interface [polypeptide binding]; other site 234826002361 putative catalytic residues [active] 234826002362 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 234826002363 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 234826002364 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 234826002365 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 234826002366 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 234826002367 Putative proton exit pathway; other site 234826002368 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 234826002369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234826002370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234826002371 catalytic residue [active] 234826002372 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 234826002373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234826002374 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 234826002375 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234826002376 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234826002377 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 234826002378 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 234826002379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234826002380 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 234826002381 active site 234826002382 metal binding site [ion binding]; metal-binding site 234826002383 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 234826002384 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 234826002385 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 234826002386 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 234826002387 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 234826002388 Cell division protein FtsA; Region: FtsA; smart00842 234826002389 Cell division protein FtsA; Region: FtsA; pfam14450 234826002390 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 234826002391 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 234826002392 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 234826002393 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 234826002394 FtsH Extracellular; Region: FtsH_ext; pfam06480 234826002395 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 234826002396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826002397 Walker A motif; other site 234826002398 ATP binding site [chemical binding]; other site 234826002399 Walker B motif; other site 234826002400 arginine finger; other site 234826002401 Peptidase family M41; Region: Peptidase_M41; pfam01434 234826002402 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 234826002403 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 234826002404 SEC-C motif; Region: SEC-C; pfam02810 234826002405 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 234826002406 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 234826002407 CcmB protein; Region: CcmB; cl17444 234826002408 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 234826002409 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 234826002410 AAA domain; Region: AAA_26; pfam13500 234826002411 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 234826002412 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 234826002413 P loop; other site 234826002414 GTP binding site [chemical binding]; other site 234826002415 isocitrate dehydrogenase; Validated; Region: PRK09222 234826002416 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 234826002417 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 234826002418 DHH family; Region: DHH; pfam01368 234826002419 DHHA1 domain; Region: DHHA1; pfam02272 234826002420 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 234826002421 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 234826002422 active site 234826002423 NTP binding site [chemical binding]; other site 234826002424 metal binding triad [ion binding]; metal-binding site 234826002425 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 234826002426 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 234826002427 active site 234826002428 multimer interface [polypeptide binding]; other site 234826002429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234826002430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234826002431 non-specific DNA binding site [nucleotide binding]; other site 234826002432 salt bridge; other site 234826002433 sequence-specific DNA binding site [nucleotide binding]; other site 234826002434 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002435 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002436 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002437 Protein of unknown function (DUF1455); Region: DUF1455; pfam07306 234826002438 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002439 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002440 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234826002441 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 234826002442 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 234826002443 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002444 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002445 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002446 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002447 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 234826002448 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 234826002449 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 234826002450 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 234826002451 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 234826002452 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826002453 active site 234826002454 HIGH motif; other site 234826002455 nucleotide binding site [chemical binding]; other site 234826002456 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234826002457 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234826002458 active site 234826002459 KMSKS motif; other site 234826002460 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 234826002461 tRNA binding surface [nucleotide binding]; other site 234826002462 anticodon binding site; other site 234826002463 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 234826002464 SmpB-tmRNA interface; other site 234826002465 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 234826002466 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 234826002467 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 234826002468 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 234826002469 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 234826002470 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 234826002471 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234826002472 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 234826002473 beta subunit interaction interface [polypeptide binding]; other site 234826002474 Walker A motif; other site 234826002475 ATP binding site [chemical binding]; other site 234826002476 Walker B motif; other site 234826002477 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234826002478 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 234826002479 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 234826002480 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 234826002481 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 234826002482 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 234826002483 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234826002484 FtsX-like permease family; Region: FtsX; pfam02687 234826002485 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 234826002486 Glutamate-cysteine ligase; Region: GshA; pfam08886 234826002487 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 234826002488 Citrate synthase; Region: Citrate_synt; pfam00285 234826002489 oxalacetate binding site [chemical binding]; other site 234826002490 citrylCoA binding site [chemical binding]; other site 234826002491 coenzyme A binding site [chemical binding]; other site 234826002492 catalytic triad [active] 234826002493 GMP synthase; Reviewed; Region: guaA; PRK00074 234826002494 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 234826002495 AMP/PPi binding site [chemical binding]; other site 234826002496 candidate oxyanion hole; other site 234826002497 catalytic triad [active] 234826002498 potential glutamine specificity residues [chemical binding]; other site 234826002499 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 234826002500 ATP Binding subdomain [chemical binding]; other site 234826002501 Ligand Binding sites [chemical binding]; other site 234826002502 Dimerization subdomain; other site 234826002503 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 234826002504 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234826002505 E3 interaction surface; other site 234826002506 lipoyl attachment site [posttranslational modification]; other site 234826002507 e3 binding domain; Region: E3_binding; pfam02817 234826002508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234826002509 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 234826002510 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 234826002511 putative active site; other site 234826002512 catalytic residue [active] 234826002513 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 234826002514 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 234826002515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234826002516 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 234826002517 Protein export membrane protein; Region: SecD_SecF; cl14618 234826002518 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 234826002519 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 234826002520 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 234826002521 substrate-cofactor binding pocket; other site 234826002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234826002523 catalytic residue [active] 234826002524 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 234826002525 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 234826002526 active site 234826002527 HIGH motif; other site 234826002528 dimer interface [polypeptide binding]; other site 234826002529 KMSKS motif; other site 234826002530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234826002531 RNA binding surface [nucleotide binding]; other site 234826002532 glutamine synthetase, type I; Region: GlnA; TIGR00653 234826002533 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234826002534 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234826002535 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 234826002536 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 234826002537 Mg++ binding site [ion binding]; other site 234826002538 putative catalytic motif [active] 234826002539 putative substrate binding site [chemical binding]; other site 234826002540 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234826002541 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234826002542 substrate binding pocket [chemical binding]; other site 234826002543 chain length determination region; other site 234826002544 substrate-Mg2+ binding site; other site 234826002545 catalytic residues [active] 234826002546 aspartate-rich region 1; other site 234826002547 active site lid residues [active] 234826002548 aspartate-rich region 2; other site 234826002549 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 234826002550 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 234826002551 Walker A/P-loop; other site 234826002552 ATP binding site [chemical binding]; other site 234826002553 Q-loop/lid; other site 234826002554 ABC transporter signature motif; other site 234826002555 Walker B; other site 234826002556 D-loop; other site 234826002557 H-loop/switch region; other site 234826002558 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234826002559 Permease; Region: Permease; pfam02405 234826002560 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 234826002561 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 234826002562 substrate binding site [chemical binding]; other site 234826002563 hexamer interface [polypeptide binding]; other site 234826002564 metal binding site [ion binding]; metal-binding site 234826002565 DNA polymerase I; Provisional; Region: PRK05755 234826002566 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 234826002567 active site 234826002568 metal binding site 1 [ion binding]; metal-binding site 234826002569 putative 5' ssDNA interaction site; other site 234826002570 metal binding site 3; metal-binding site 234826002571 metal binding site 2 [ion binding]; metal-binding site 234826002572 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 234826002573 putative DNA binding site [nucleotide binding]; other site 234826002574 putative metal binding site [ion binding]; other site 234826002575 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 234826002576 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 234826002577 active site 234826002578 DNA binding site [nucleotide binding] 234826002579 catalytic site [active] 234826002580 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 234826002581 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234826002582 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234826002583 recombination protein F; Reviewed; Region: recF; PRK00064 234826002584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826002585 Walker A/P-loop; other site 234826002586 ATP binding site [chemical binding]; other site 234826002587 Q-loop/lid; other site 234826002588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234826002589 ABC transporter signature motif; other site 234826002590 Walker B; other site 234826002591 D-loop; other site 234826002592 H-loop/switch region; other site 234826002593 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002594 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002595 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002596 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002597 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002598 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002599 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002600 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002601 MviN-like protein; Region: MVIN; pfam03023 234826002602 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 234826002603 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 234826002604 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 234826002605 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234826002606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234826002607 putative acyl-acceptor binding pocket; other site 234826002608 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 234826002609 active site 234826002610 catalytic residues [active] 234826002611 metal binding site [ion binding]; metal-binding site 234826002612 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 234826002613 Fe-S cluster binding site [ion binding]; other site 234826002614 active site 234826002615 outer membrane protein RatB; Provisional; Region: PRK15314 234826002616 excinuclease ABC subunit B; Provisional; Region: PRK05298 234826002617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234826002618 ATP binding site [chemical binding]; other site 234826002619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234826002620 nucleotide binding region [chemical binding]; other site 234826002621 ATP-binding site [chemical binding]; other site 234826002622 Ultra-violet resistance protein B; Region: UvrB; pfam12344 234826002623 UvrB/uvrC motif; Region: UVR; pfam02151 234826002624 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 234826002625 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 234826002626 TrbC/VIRB2 family; Region: TrbC; cl01583 234826002627 TrbC/VIRB2 family; Region: TrbC; pfam04956 234826002628 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 234826002629 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002630 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002631 Surface antigen; Region: Surface_Ag_2; pfam01617 234826002632 cell division protein FtsZ; Validated; Region: PRK09330 234826002633 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 234826002634 nucleotide binding site [chemical binding]; other site 234826002635 SulA interaction site; other site 234826002636 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 234826002637 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234826002638 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234826002639 P-loop; other site 234826002640 Magnesium ion binding site [ion binding]; other site 234826002641 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234826002642 Magnesium ion binding site [ion binding]; other site 234826002643 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 234826002644 ParB-like nuclease domain; Region: ParBc; pfam02195 234826002645 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 234826002646 RimM N-terminal domain; Region: RimM; pfam01782 234826002647 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 234826002648 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 234826002649 Competence-damaged protein; Region: CinA; pfam02464 234826002650 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 234826002651 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 234826002652 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 234826002653 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 234826002654 active site 234826002655 dimer interface [polypeptide binding]; other site 234826002656 motif 1; other site 234826002657 motif 2; other site 234826002658 motif 3; other site 234826002659 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 234826002660 anticodon binding site; other site 234826002661 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 234826002662 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 234826002663 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 234826002664 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 234826002665 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 234826002666 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 234826002667 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 234826002668 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234826002669 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 234826002670 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964 234826002671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234826002672 Walker A motif; other site 234826002673 ATP binding site [chemical binding]; other site 234826002674 Walker B motif; other site 234826002675 arginine finger; other site 234826002676 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 234826002677 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 234826002678 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 234826002679 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 234826002680 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 234826002681 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 234826002682 conserved cys residue [active] 234826002683 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 234826002684 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 234826002685 S-adenosylmethionine synthetase; Validated; Region: PRK05250 234826002686 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 234826002687 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 234826002688 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 234826002689 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234826002690 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 234826002691 motif 1; other site 234826002692 dimer interface [polypeptide binding]; other site 234826002693 active site 234826002694 motif 2; other site 234826002695 motif 3; other site 234826002696 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 234826002697 chaperone protein DnaJ; Provisional; Region: PRK10767 234826002698 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234826002699 HSP70 interaction site [polypeptide binding]; other site 234826002700 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 234826002701 substrate binding site [polypeptide binding]; other site 234826002702 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234826002703 Zn binding sites [ion binding]; other site 234826002704 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 234826002705 dimer interface [polypeptide binding]; other site 234826002706 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 234826002707 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 234826002708 dimerization interface [polypeptide binding]; other site 234826002709 active site 234826002710 membrane protein; Provisional; Region: PRK14396 234826002711 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 234826002712 active site 234826002713 putative DNA-binding cleft [nucleotide binding]; other site 234826002714 dimer interface [polypeptide binding]; other site 234826002715 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 234826002716 Subunit III/VIIa interface [polypeptide binding]; other site 234826002717 Phospholipid binding site [chemical binding]; other site 234826002718 Subunit I/III interface [polypeptide binding]; other site 234826002719 Subunit III/VIb interface [polypeptide binding]; other site 234826002720 Subunit III/VIa interface; other site 234826002721 Subunit III/Vb interface [polypeptide binding]; other site 234826002722 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 234826002723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234826002724 Transporter associated domain; Region: CorC_HlyC; smart01091 234826002725 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 234826002726 Phage-related protein [Function unknown]; Region: COG4695 234826002727 Phage portal protein; Region: Phage_portal; pfam04860 234826002728 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 234826002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826002730 S-adenosylmethionine binding site [chemical binding]; other site 234826002731 quinolinate synthetase; Provisional; Region: PRK09375 234826002732 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 234826002733 4Fe-4S binding domain; Region: Fer4; pfam00037 234826002734 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 234826002735 ketol-acid reductoisomerase; Provisional; Region: PRK05479 234826002736 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 234826002737 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 234826002738 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 234826002739 type IV secretion system component VirD4; Provisional; Region: PRK13897 234826002740 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 234826002741 Walker A motif; other site 234826002742 ATP binding site [chemical binding]; other site 234826002743 Walker B motif; other site 234826002744 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 234826002745 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234826002746 Walker A motif; other site 234826002747 hexamer interface [polypeptide binding]; other site 234826002748 ATP binding site [chemical binding]; other site 234826002749 Walker B motif; other site 234826002750 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 234826002751 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 234826002752 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 234826002753 VirB7 interaction site; other site 234826002754 VirB8 protein; Region: VirB8; pfam04335 234826002755 GTP cyclohydrolase; Provisional; Region: PRK08815 234826002756 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 234826002757 dimerization interface [polypeptide binding]; other site 234826002758 active site 234826002759 Tetratricopeptide repeat; Region: TPR_16; pfam13432 234826002760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234826002761 TPR motif; other site 234826002762 binding surface 234826002763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234826002764 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234826002765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234826002766 S-adenosylmethionine binding site [chemical binding]; other site 234826002767 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 234826002768 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234826002769 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234826002770 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 234826002771 Phosphoglycerate kinase; Region: PGK; pfam00162 234826002772 substrate binding site [chemical binding]; other site 234826002773 hinge regions; other site 234826002774 ADP binding site [chemical binding]; other site 234826002775 catalytic site [active] 234826002776 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 234826002777 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 234826002778 generic binding surface II; other site 234826002779 generic binding surface I; other site 234826002780 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 234826002781 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 234826002782 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 234826002783 trimer interface [polypeptide binding]; other site 234826002784 active site 234826002785 substrate binding site [chemical binding]; other site 234826002786 CoA binding site [chemical binding]; other site 234826002787 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 234826002788 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 234826002789 trmE is a tRNA modification GTPase; Region: trmE; cd04164 234826002790 G1 box; other site 234826002791 GTP/Mg2+ binding site [chemical binding]; other site 234826002792 Switch I region; other site 234826002793 G2 box; other site 234826002794 Switch II region; other site 234826002795 G3 box; other site 234826002796 G4 box; other site 234826002797 G5 box; other site 234826002798 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 234826002799 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 234826002800 Flavoprotein; Region: Flavoprotein; pfam02441 234826002801 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 234826002802 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 234826002803 ssDNA binding site; other site 234826002804 generic binding surface II; other site 234826002805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234826002806 ATP binding site [chemical binding]; other site 234826002807 putative Mg++ binding site [ion binding]; other site 234826002808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234826002809 nucleotide binding region [chemical binding]; other site 234826002810 ATP-binding site [chemical binding]; other site 234826002811 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 234826002812 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 234826002813 putative NAD(P) binding site [chemical binding]; other site 234826002814 active site 234826002815 amidophosphoribosyltransferase; Provisional; Region: PRK09123 234826002816 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 234826002817 active site 234826002818 tetramer interface [polypeptide binding]; other site 234826002819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234826002820 active site 234826002821 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 234826002822 putative active site [active] 234826002823 catalytic residue [active] 234826002824 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 234826002825 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 234826002826 5S rRNA interface [nucleotide binding]; other site 234826002827 CTC domain interface [polypeptide binding]; other site 234826002828 L16 interface [polypeptide binding]; other site 234826002829 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 234826002830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234826002831 active site 234826002832 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 234826002833 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 234826002834 metal binding site [ion binding]; metal-binding site 234826002835 dimer interface [polypeptide binding]; other site 234826002836 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 234826002837 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 234826002838 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 234826002839 TrkA-N domain; Region: TrkA_N; pfam02254 234826002840 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 234826002841 putative catalytic residue [active] 234826002842 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 234826002843 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 234826002844 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234826002845 alpha subunit interface [polypeptide binding]; other site 234826002846 TPP binding site [chemical binding]; other site 234826002847 heterodimer interface [polypeptide binding]; other site 234826002848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234826002849 protease TldD; Provisional; Region: tldD; PRK10735 234826002850 GTP-binding protein YchF; Reviewed; Region: PRK09601 234826002851 YchF GTPase; Region: YchF; cd01900 234826002852 G1 box; other site 234826002853 GTP/Mg2+ binding site [chemical binding]; other site 234826002854 Switch I region; other site 234826002855 G2 box; other site 234826002856 Switch II region; other site 234826002857 G3 box; other site 234826002858 G4 box; other site 234826002859 G5 box; other site 234826002860 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 234826002861 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 234826002862 homotrimer interaction site [polypeptide binding]; other site 234826002863 zinc binding site [ion binding]; other site 234826002864 CDP-binding sites; other site 234826002865 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 234826002866 substrate binding site; other site 234826002867 dimer interface; other site