-- dump date 20140618_204439 -- class Genbank::misc_feature -- table misc_feature_note -- id note 491915000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 491915000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 491915000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915000004 Walker A motif; other site 491915000005 ATP binding site [chemical binding]; other site 491915000006 Walker B motif; other site 491915000007 arginine finger; other site 491915000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 491915000009 DnaA box-binding interface [nucleotide binding]; other site 491915000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 491915000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 491915000012 putative DNA binding surface [nucleotide binding]; other site 491915000013 dimer interface [polypeptide binding]; other site 491915000014 beta-clamp/clamp loader binding surface; other site 491915000015 beta-clamp/translesion DNA polymerase binding surface; other site 491915000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 491915000017 recombination protein F; Reviewed; Region: recF; PRK00064 491915000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 491915000019 Walker A/P-loop; other site 491915000020 ATP binding site [chemical binding]; other site 491915000021 Q-loop/lid; other site 491915000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915000023 ABC transporter signature motif; other site 491915000024 Walker B; other site 491915000025 D-loop; other site 491915000026 H-loop/switch region; other site 491915000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 491915000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915000029 Mg2+ binding site [ion binding]; other site 491915000030 G-X-G motif; other site 491915000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 491915000032 anchoring element; other site 491915000033 dimer interface [polypeptide binding]; other site 491915000034 ATP binding site [chemical binding]; other site 491915000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 491915000036 active site 491915000037 putative metal-binding site [ion binding]; other site 491915000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 491915000039 DNA gyrase subunit A; Validated; Region: PRK05560 491915000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 491915000041 CAP-like domain; other site 491915000042 active site 491915000043 primary dimer interface [polypeptide binding]; other site 491915000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 491915000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915000052 Zn2+ binding site [ion binding]; other site 491915000053 Mg2+ binding site [ion binding]; other site 491915000054 YaaC-like Protein; Region: YaaC; pfam14175 491915000055 YaaC-like Protein; Region: YaaC; pfam14175 491915000056 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 491915000057 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 491915000058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 491915000059 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 491915000060 active site 491915000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 491915000062 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 491915000063 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 491915000064 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 491915000065 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 491915000066 active site 491915000067 multimer interface [polypeptide binding]; other site 491915000068 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 491915000069 predicted active site [active] 491915000070 catalytic triad [active] 491915000071 T-box leader; Aflv_R006 491915000072 seryl-tRNA synthetase; Provisional; Region: PRK05431 491915000073 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 491915000074 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 491915000075 dimer interface [polypeptide binding]; other site 491915000076 active site 491915000077 motif 1; other site 491915000078 motif 2; other site 491915000079 motif 3; other site 491915000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 491915000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 491915000082 Substrate-binding site [chemical binding]; other site 491915000083 Substrate specificity [chemical binding]; other site 491915000084 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 491915000085 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 491915000086 Substrate-binding site [chemical binding]; other site 491915000087 Substrate specificity [chemical binding]; other site 491915000088 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 491915000089 nucleoside/Zn binding site; other site 491915000090 dimer interface [polypeptide binding]; other site 491915000091 catalytic motif [active] 491915000092 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 491915000093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915000094 Walker A motif; other site 491915000095 ATP binding site [chemical binding]; other site 491915000096 Walker B motif; other site 491915000097 arginine finger; other site 491915000098 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 491915000099 hypothetical protein; Validated; Region: PRK00153 491915000100 recombination protein RecR; Reviewed; Region: recR; PRK00076 491915000101 RecR protein; Region: RecR; pfam02132 491915000102 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 491915000103 putative active site [active] 491915000104 putative metal-binding site [ion binding]; other site 491915000105 tetramer interface [polypeptide binding]; other site 491915000106 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 491915000107 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 491915000108 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 491915000109 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 491915000110 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 491915000111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915000112 catalytic residue [active] 491915000113 thymidylate kinase; Validated; Region: tmk; PRK00698 491915000114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 491915000115 TMP-binding site; other site 491915000116 ATP-binding site [chemical binding]; other site 491915000117 DNA polymerase III subunit delta'; Validated; Region: PRK08058 491915000118 DNA polymerase III subunit delta'; Validated; Region: PRK08485 491915000119 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 491915000120 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 491915000121 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 491915000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915000123 S-adenosylmethionine binding site [chemical binding]; other site 491915000124 Predicted methyltransferases [General function prediction only]; Region: COG0313 491915000125 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 491915000126 putative SAM binding site [chemical binding]; other site 491915000127 putative homodimer interface [polypeptide binding]; other site 491915000128 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 491915000129 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 491915000130 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 491915000131 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 491915000132 active site 491915000133 HIGH motif; other site 491915000134 KMSKS motif; other site 491915000135 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 491915000136 tRNA binding surface [nucleotide binding]; other site 491915000137 anticodon binding site; other site 491915000138 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 491915000139 dimer interface [polypeptide binding]; other site 491915000140 putative tRNA-binding site [nucleotide binding]; other site 491915000141 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 491915000142 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 491915000143 active site 491915000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 491915000145 Domain of unknown function (DUF348); Region: DUF348; pfam03990 491915000146 Domain of unknown function (DUF348); Region: DUF348; pfam03990 491915000147 Domain of unknown function (DUF348); Region: DUF348; pfam03990 491915000148 G5 domain; Region: G5; pfam07501 491915000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 491915000150 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 491915000151 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 491915000152 putative active site [active] 491915000153 putative metal binding site [ion binding]; other site 491915000154 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 491915000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 491915000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915000157 S-adenosylmethionine binding site [chemical binding]; other site 491915000158 YabG peptidase U57; Region: Peptidase_U57; pfam05582 491915000159 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 491915000160 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 491915000161 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 491915000162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 491915000163 pur operon repressor; Provisional; Region: PRK09213 491915000164 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 491915000165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915000166 active site 491915000167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 491915000168 homotrimer interaction site [polypeptide binding]; other site 491915000169 putative active site [active] 491915000170 regulatory protein SpoVG; Reviewed; Region: PRK13259 491915000171 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 491915000172 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 491915000173 Substrate binding site; other site 491915000174 Mg++ binding site; other site 491915000175 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 491915000176 active site 491915000177 substrate binding site [chemical binding]; other site 491915000178 CoA binding site [chemical binding]; other site 491915000179 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 491915000180 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 491915000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915000182 active site 491915000183 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 491915000184 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 491915000185 5S rRNA interface [nucleotide binding]; other site 491915000186 CTC domain interface [polypeptide binding]; other site 491915000187 L16 interface [polypeptide binding]; other site 491915000188 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 491915000189 putative active site [active] 491915000190 catalytic residue [active] 491915000191 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 491915000192 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 491915000193 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 491915000194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915000195 ATP binding site [chemical binding]; other site 491915000196 putative Mg++ binding site [ion binding]; other site 491915000197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915000198 nucleotide binding region [chemical binding]; other site 491915000199 ATP-binding site [chemical binding]; other site 491915000200 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 491915000201 stage V sporulation protein T; Region: spore_V_T; TIGR02851 491915000202 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 491915000203 stage V sporulation protein B; Region: spore_V_B; TIGR02900 491915000204 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 491915000205 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 491915000206 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 491915000207 putative SAM binding site [chemical binding]; other site 491915000208 putative homodimer interface [polypeptide binding]; other site 491915000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 491915000210 homodimer interface [polypeptide binding]; other site 491915000211 metal binding site [ion binding]; metal-binding site 491915000212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 491915000213 homodimer interface [polypeptide binding]; other site 491915000214 active site 491915000215 putative chemical substrate binding site [chemical binding]; other site 491915000216 metal binding site [ion binding]; metal-binding site 491915000217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915000218 RNA binding surface [nucleotide binding]; other site 491915000219 sporulation protein YabP; Region: spore_yabP; TIGR02892 491915000220 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 491915000221 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 491915000222 Septum formation initiator; Region: DivIC; pfam04977 491915000223 hypothetical protein; Provisional; Region: PRK08582 491915000224 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 491915000225 RNA binding site [nucleotide binding]; other site 491915000226 stage II sporulation protein E; Region: spore_II_E; TIGR02865 491915000227 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 491915000228 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 491915000229 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 491915000230 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 491915000231 metal ion-dependent adhesion site (MIDAS); other site 491915000232 Protein kinase domain; Region: Pkinase; pfam00069 491915000233 Catalytic domain of Protein Kinases; Region: PKc; cd00180 491915000234 active site 491915000235 ATP binding site [chemical binding]; other site 491915000236 substrate binding site [chemical binding]; other site 491915000237 activation loop (A-loop); other site 491915000238 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 491915000239 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 491915000240 Ligand Binding Site [chemical binding]; other site 491915000241 TilS substrate C-terminal domain; Region: TilS_C; smart00977 491915000242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915000243 active site 491915000244 FtsH Extracellular; Region: FtsH_ext; pfam06480 491915000245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 491915000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915000247 Walker A motif; other site 491915000248 ATP binding site [chemical binding]; other site 491915000249 Walker B motif; other site 491915000250 arginine finger; other site 491915000251 Peptidase family M41; Region: Peptidase_M41; pfam01434 491915000252 pantothenate kinase; Reviewed; Region: PRK13318 491915000253 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 491915000254 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 491915000255 dimerization interface [polypeptide binding]; other site 491915000256 domain crossover interface; other site 491915000257 redox-dependent activation switch; other site 491915000258 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 491915000259 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 491915000260 dimer interface [polypeptide binding]; other site 491915000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915000262 catalytic residue [active] 491915000263 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 491915000264 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 491915000265 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 491915000266 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 491915000267 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 491915000268 glutamine binding [chemical binding]; other site 491915000269 catalytic triad [active] 491915000270 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 491915000271 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 491915000272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915000273 catalytic residue [active] 491915000274 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 491915000275 dihydropteroate synthase; Region: DHPS; TIGR01496 491915000276 substrate binding pocket [chemical binding]; other site 491915000277 dimer interface [polypeptide binding]; other site 491915000278 inhibitor binding site; inhibition site 491915000279 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 491915000280 homooctamer interface [polypeptide binding]; other site 491915000281 active site 491915000282 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 491915000283 catalytic center binding site [active] 491915000284 ATP binding site [chemical binding]; other site 491915000285 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 491915000286 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 491915000287 FMN binding site [chemical binding]; other site 491915000288 active site 491915000289 catalytic residues [active] 491915000290 substrate binding site [chemical binding]; other site 491915000291 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 491915000292 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 491915000293 dimer interface [polypeptide binding]; other site 491915000294 putative anticodon binding site; other site 491915000295 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 491915000296 motif 1; other site 491915000297 active site 491915000298 motif 2; other site 491915000299 motif 3; other site 491915000300 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 491915000301 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 491915000302 UvrB/uvrC motif; Region: UVR; pfam02151 491915000303 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 491915000304 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 491915000305 ADP binding site [chemical binding]; other site 491915000306 phosphagen binding site; other site 491915000307 substrate specificity loop; other site 491915000308 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 491915000309 Clp amino terminal domain; Region: Clp_N; pfam02861 491915000310 Clp amino terminal domain; Region: Clp_N; pfam02861 491915000311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915000312 Walker A motif; other site 491915000313 ATP binding site [chemical binding]; other site 491915000314 Walker B motif; other site 491915000315 arginine finger; other site 491915000316 UvrB/uvrC motif; Region: UVR; pfam02151 491915000317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915000318 Walker A motif; other site 491915000319 ATP binding site [chemical binding]; other site 491915000320 Walker B motif; other site 491915000321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 491915000322 DNA repair protein RadA; Provisional; Region: PRK11823 491915000323 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 491915000324 Walker A motif/ATP binding site; other site 491915000325 ATP binding site [chemical binding]; other site 491915000326 Walker B motif; other site 491915000327 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 491915000328 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 491915000329 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 491915000330 putative active site [active] 491915000331 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 491915000332 substrate binding site; other site 491915000333 dimer interface; other site 491915000334 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 491915000335 homotrimer interaction site [polypeptide binding]; other site 491915000336 zinc binding site [ion binding]; other site 491915000337 CDP-binding sites; other site 491915000338 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 491915000339 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 491915000340 HIGH motif; other site 491915000341 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 491915000342 active site 491915000343 KMSKS motif; other site 491915000344 serine O-acetyltransferase; Region: cysE; TIGR01172 491915000345 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 491915000346 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 491915000347 trimer interface [polypeptide binding]; other site 491915000348 active site 491915000349 substrate binding site [chemical binding]; other site 491915000350 CoA binding site [chemical binding]; other site 491915000351 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 491915000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 491915000353 active site 491915000354 HIGH motif; other site 491915000355 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 491915000356 KMSKS motif; other site 491915000357 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 491915000358 tRNA binding surface [nucleotide binding]; other site 491915000359 anticodon binding site; other site 491915000360 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 491915000361 active site 491915000362 metal binding site [ion binding]; metal-binding site 491915000363 dimerization interface [polypeptide binding]; other site 491915000364 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 491915000365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 491915000366 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 491915000367 YacP-like NYN domain; Region: NYN_YacP; cl01491 491915000368 RNA polymerase factor sigma-70; Validated; Region: PRK08295 491915000369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915000370 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 491915000371 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 491915000372 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 491915000373 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 491915000374 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 491915000375 putative homodimer interface [polypeptide binding]; other site 491915000376 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 491915000377 heterodimer interface [polypeptide binding]; other site 491915000378 homodimer interface [polypeptide binding]; other site 491915000379 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 491915000380 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 491915000381 putative thiostrepton binding site; other site 491915000382 23S rRNA interface [nucleotide binding]; other site 491915000383 L7/L12 interface [polypeptide binding]; other site 491915000384 L25 interface [polypeptide binding]; other site 491915000385 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 491915000386 mRNA/rRNA interface [nucleotide binding]; other site 491915000387 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 491915000388 23S rRNA interface [nucleotide binding]; other site 491915000389 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 491915000390 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 491915000391 core dimer interface [polypeptide binding]; other site 491915000392 peripheral dimer interface [polypeptide binding]; other site 491915000393 L10 interface [polypeptide binding]; other site 491915000394 L11 interface [polypeptide binding]; other site 491915000395 putative EF-Tu interaction site [polypeptide binding]; other site 491915000396 putative EF-G interaction site [polypeptide binding]; other site 491915000397 Methyltransferase domain; Region: Methyltransf_31; pfam13847 491915000398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915000399 S-adenosylmethionine binding site [chemical binding]; other site 491915000400 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 491915000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 491915000402 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 491915000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 491915000404 RPB1 interaction site [polypeptide binding]; other site 491915000405 RPB10 interaction site [polypeptide binding]; other site 491915000406 RPB11 interaction site [polypeptide binding]; other site 491915000407 RPB3 interaction site [polypeptide binding]; other site 491915000408 RPB12 interaction site [polypeptide binding]; other site 491915000409 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 491915000410 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 491915000411 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 491915000412 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 491915000413 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 491915000414 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 491915000415 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 491915000416 G-loop; other site 491915000417 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 491915000418 DNA binding site [nucleotide binding] 491915000419 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 491915000420 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 491915000421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 491915000422 S17 interaction site [polypeptide binding]; other site 491915000423 S8 interaction site; other site 491915000424 16S rRNA interaction site [nucleotide binding]; other site 491915000425 streptomycin interaction site [chemical binding]; other site 491915000426 23S rRNA interaction site [nucleotide binding]; other site 491915000427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 491915000428 30S ribosomal protein S7; Validated; Region: PRK05302 491915000429 elongation factor G; Reviewed; Region: PRK00007 491915000430 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 491915000431 G1 box; other site 491915000432 putative GEF interaction site [polypeptide binding]; other site 491915000433 GTP/Mg2+ binding site [chemical binding]; other site 491915000434 Switch I region; other site 491915000435 G2 box; other site 491915000436 G3 box; other site 491915000437 Switch II region; other site 491915000438 G4 box; other site 491915000439 G5 box; other site 491915000440 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 491915000441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 491915000442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 491915000443 elongation factor Tu; Reviewed; Region: PRK00049 491915000444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 491915000445 G1 box; other site 491915000446 GEF interaction site [polypeptide binding]; other site 491915000447 GTP/Mg2+ binding site [chemical binding]; other site 491915000448 Switch I region; other site 491915000449 G2 box; other site 491915000450 G3 box; other site 491915000451 Switch II region; other site 491915000452 G4 box; other site 491915000453 G5 box; other site 491915000454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 491915000455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 491915000456 Antibiotic Binding Site [chemical binding]; other site 491915000457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 491915000458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 491915000459 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 491915000460 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 491915000461 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 491915000462 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 491915000463 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 491915000464 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 491915000465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 491915000466 putative translocon binding site; other site 491915000467 protein-rRNA interface [nucleotide binding]; other site 491915000468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 491915000469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 491915000470 G-X-X-G motif; other site 491915000471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 491915000472 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 491915000473 23S rRNA interface [nucleotide binding]; other site 491915000474 5S rRNA interface [nucleotide binding]; other site 491915000475 putative antibiotic binding site [chemical binding]; other site 491915000476 L25 interface [polypeptide binding]; other site 491915000477 L27 interface [polypeptide binding]; other site 491915000478 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 491915000479 23S rRNA interface [nucleotide binding]; other site 491915000480 putative translocon interaction site; other site 491915000481 signal recognition particle (SRP54) interaction site; other site 491915000482 L23 interface [polypeptide binding]; other site 491915000483 trigger factor interaction site; other site 491915000484 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 491915000485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 491915000486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 491915000487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 491915000488 RNA binding site [nucleotide binding]; other site 491915000489 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 491915000490 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 491915000491 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 491915000492 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 491915000493 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 491915000494 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 491915000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 491915000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 491915000497 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 491915000498 5S rRNA interface [nucleotide binding]; other site 491915000499 23S rRNA interface [nucleotide binding]; other site 491915000500 L5 interface [polypeptide binding]; other site 491915000501 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 491915000502 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 491915000503 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 491915000504 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 491915000505 23S rRNA binding site [nucleotide binding]; other site 491915000506 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 491915000507 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 491915000508 SecY translocase; Region: SecY; pfam00344 491915000509 adenylate kinase; Reviewed; Region: adk; PRK00279 491915000510 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 491915000511 AMP-binding site [chemical binding]; other site 491915000512 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 491915000513 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 491915000514 active site 491915000515 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 491915000516 rRNA binding site [nucleotide binding]; other site 491915000517 predicted 30S ribosome binding site; other site 491915000518 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 491915000519 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 491915000520 30S ribosomal protein S13; Region: bact_S13; TIGR03631 491915000521 30S ribosomal protein S11; Validated; Region: PRK05309 491915000522 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 491915000523 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 491915000524 alphaNTD homodimer interface [polypeptide binding]; other site 491915000525 alphaNTD - beta interaction site [polypeptide binding]; other site 491915000526 alphaNTD - beta' interaction site [polypeptide binding]; other site 491915000527 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 491915000528 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 491915000529 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 491915000530 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915000531 Walker A/P-loop; other site 491915000532 ATP binding site [chemical binding]; other site 491915000533 Q-loop/lid; other site 491915000534 ABC transporter signature motif; other site 491915000535 Walker B; other site 491915000536 D-loop; other site 491915000537 H-loop/switch region; other site 491915000538 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 491915000539 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915000540 Walker A/P-loop; other site 491915000541 ATP binding site [chemical binding]; other site 491915000542 Q-loop/lid; other site 491915000543 ABC transporter signature motif; other site 491915000544 Walker B; other site 491915000545 D-loop; other site 491915000546 H-loop/switch region; other site 491915000547 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 491915000548 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 491915000549 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 491915000550 dimerization interface 3.5A [polypeptide binding]; other site 491915000551 active site 491915000552 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 491915000553 23S rRNA interface [nucleotide binding]; other site 491915000554 L3 interface [polypeptide binding]; other site 491915000555 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 491915000556 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 491915000557 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 491915000558 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 491915000559 active site 491915000560 metal binding site [ion binding]; metal-binding site 491915000561 Domain of unknown function DUF59; Region: DUF59; cl00941 491915000562 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 491915000563 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 491915000564 Protein of unknown function (DUF445); Region: DUF445; pfam04286 491915000565 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 491915000566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 491915000567 polysaccharide deacetylase family sporulation protein PdaB; Region: spore_ybaN_pdaB; TIGR02764 491915000568 Arginase family; Region: Arginase; cd09989 491915000569 agmatinase; Region: agmatinase; TIGR01230 491915000570 active site 491915000571 Mn binding site [ion binding]; other site 491915000572 oligomer interface [polypeptide binding]; other site 491915000573 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 491915000574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915000575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915000576 DNA binding residues [nucleotide binding] 491915000577 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 491915000578 Putative zinc-finger; Region: zf-HC2; pfam13490 491915000579 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 491915000580 Uncharacterized conserved protein [Function unknown]; Region: COG1624 491915000581 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 491915000582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 491915000583 YbbR-like protein; Region: YbbR; pfam07949 491915000584 YbbR-like protein; Region: YbbR; pfam07949 491915000585 YbbR-like protein; Region: YbbR; pfam07949 491915000586 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 491915000587 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 491915000588 active site 491915000589 substrate binding site [chemical binding]; other site 491915000590 metal binding site [ion binding]; metal-binding site 491915000591 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 491915000592 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 491915000593 glutaminase active site [active] 491915000594 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 491915000595 dimer interface [polypeptide binding]; other site 491915000596 active site 491915000597 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 491915000598 dimer interface [polypeptide binding]; other site 491915000599 active site 491915000600 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 491915000601 Winged helix-turn helix; Region: HTH_29; pfam13551 491915000602 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915000603 Winged helix-turn helix; Region: HTH_33; pfam13592 491915000604 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915000605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915000606 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915000607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915000608 Winged helix-turn helix; Region: HTH_29; pfam13551 491915000609 Winged helix-turn helix; Region: HTH_33; pfam13592 491915000610 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 491915000611 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 491915000612 putative acyl-acceptor binding pocket; other site 491915000613 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915000614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915000615 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915000616 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 491915000617 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915000618 Transposase domain (DUF772); Region: DUF772; pfam05598 491915000619 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915000620 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 491915000621 Divergent AAA domain; Region: AAA_4; pfam04326 491915000622 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 491915000623 Homeodomain-like domain; Region: HTH_23; pfam13384 491915000624 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 491915000625 PemK-like protein; Region: PemK; cl00995 491915000626 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 491915000627 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 491915000628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 491915000629 Histidine kinase; Region: HisKA_3; pfam07730 491915000630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915000631 ATP binding site [chemical binding]; other site 491915000632 Mg2+ binding site [ion binding]; other site 491915000633 G-X-G motif; other site 491915000634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915000635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915000636 active site 491915000637 phosphorylation site [posttranslational modification] 491915000638 intermolecular recognition site; other site 491915000639 dimerization interface [polypeptide binding]; other site 491915000640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915000641 DNA binding residues [nucleotide binding] 491915000642 dimerization interface [polypeptide binding]; other site 491915000643 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 491915000644 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 491915000645 DNA binding residues [nucleotide binding] 491915000646 dimer interface [polypeptide binding]; other site 491915000647 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 491915000648 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 491915000649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915000650 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 491915000651 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 491915000652 Carbon starvation protein CstA; Region: CstA; pfam02554 491915000653 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 491915000654 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 491915000655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915000657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915000658 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 491915000659 FAD binding site [chemical binding]; other site 491915000660 homotetramer interface [polypeptide binding]; other site 491915000661 substrate binding pocket [chemical binding]; other site 491915000662 catalytic base [active] 491915000663 AMP-binding domain protein; Validated; Region: PRK08315 491915000664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 491915000665 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 491915000666 acyl-activating enzyme (AAE) consensus motif; other site 491915000667 acyl-activating enzyme (AAE) consensus motif; other site 491915000668 putative AMP binding site [chemical binding]; other site 491915000669 putative active site [active] 491915000670 putative CoA binding site [chemical binding]; other site 491915000671 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 491915000672 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915000673 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 491915000674 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 491915000675 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 491915000676 carboxyltransferase (CT) interaction site; other site 491915000677 biotinylation site [posttranslational modification]; other site 491915000678 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 491915000679 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 491915000680 active site 491915000681 catalytic residues [active] 491915000682 metal binding site [ion binding]; metal-binding site 491915000683 enoyl-CoA hydratase; Provisional; Region: PRK07657 491915000684 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 491915000685 substrate binding site [chemical binding]; other site 491915000686 oxyanion hole (OAH) forming residues; other site 491915000687 trimer interface [polypeptide binding]; other site 491915000688 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 491915000689 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 491915000690 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 491915000691 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 491915000692 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 491915000693 NodB motif; other site 491915000694 putative active site [active] 491915000695 putative catalytic site [active] 491915000696 putative Zn binding site [ion binding]; other site 491915000697 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 491915000698 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 491915000699 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 491915000700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 491915000701 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 491915000702 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 491915000703 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915000704 Spore germination protein; Region: Spore_permease; cl17796 491915000705 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 491915000706 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 491915000707 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 491915000708 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 491915000709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 491915000710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 491915000711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 491915000712 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 491915000713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 491915000714 ATP binding site [chemical binding]; other site 491915000715 Mg++ binding site [ion binding]; other site 491915000716 motif III; other site 491915000717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915000718 nucleotide binding region [chemical binding]; other site 491915000719 ATP-binding site [chemical binding]; other site 491915000720 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 491915000721 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 491915000722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 491915000723 alanine racemase; Reviewed; Region: alr; PRK00053 491915000724 active site 491915000725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 491915000726 dimer interface [polypeptide binding]; other site 491915000727 substrate binding site [chemical binding]; other site 491915000728 catalytic residues [active] 491915000729 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 491915000730 PemK-like protein; Region: PemK; pfam02452 491915000731 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 491915000732 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 491915000733 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 491915000734 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 491915000735 RNA binding site [nucleotide binding]; other site 491915000736 hypothetical protein; Provisional; Region: PRK04351 491915000737 SprT homologues; Region: SprT; cl01182 491915000738 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 491915000739 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 491915000740 Glycoprotease family; Region: Peptidase_M22; pfam00814 491915000741 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 491915000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915000743 Coenzyme A binding pocket [chemical binding]; other site 491915000744 UGMP family protein; Validated; Region: PRK09604 491915000745 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 491915000746 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 491915000747 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 491915000748 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 491915000749 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 491915000750 ABC transporter; Region: ABC_tran_2; pfam12848 491915000751 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 491915000752 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 491915000753 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 491915000754 CoA binding domain; Region: CoA_binding; pfam02629 491915000755 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 491915000756 CAAX protease self-immunity; Region: Abi; pfam02517 491915000757 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 491915000758 oligomerisation interface [polypeptide binding]; other site 491915000759 mobile loop; other site 491915000760 roof hairpin; other site 491915000761 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 491915000762 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 491915000763 ring oligomerisation interface [polypeptide binding]; other site 491915000764 ATP/Mg binding site [chemical binding]; other site 491915000765 stacking interactions; other site 491915000766 hinge regions; other site 491915000767 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 491915000768 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 491915000769 active site 491915000770 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 491915000771 Ligand Binding Site [chemical binding]; other site 491915000772 Molecular Tunnel; other site 491915000773 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 491915000774 heterotetramer interface [polypeptide binding]; other site 491915000775 active site pocket [active] 491915000776 cleavage site 491915000777 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 491915000778 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 491915000779 agmatinase; Region: agmatinase; TIGR01230 491915000780 oligomer interface [polypeptide binding]; other site 491915000781 putative active site [active] 491915000782 Mn binding site [ion binding]; other site 491915000783 hypothetical protein; Region: PHA00728 491915000784 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915000785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915000786 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915000787 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 491915000788 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 491915000789 TPP-binding site [chemical binding]; other site 491915000790 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 491915000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915000792 multidrug resistance protein MdtH; Provisional; Region: PRK11646 491915000793 putative substrate translocation pore; other site 491915000794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915000795 Coenzyme A binding pocket [chemical binding]; other site 491915000796 GMP synthase; Reviewed; Region: guaA; PRK00074 491915000797 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 491915000798 AMP/PPi binding site [chemical binding]; other site 491915000799 candidate oxyanion hole; other site 491915000800 catalytic triad [active] 491915000801 potential glutamine specificity residues [chemical binding]; other site 491915000802 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 491915000803 ATP Binding subdomain [chemical binding]; other site 491915000804 Ligand Binding sites [chemical binding]; other site 491915000805 Dimerization subdomain; other site 491915000806 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 491915000807 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 491915000808 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 491915000809 putative dimer interface [polypeptide binding]; other site 491915000810 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 491915000811 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 491915000812 ATP-grasp domain; Region: ATP-grasp; pfam02222 491915000813 adenylosuccinate lyase; Provisional; Region: PRK07492 491915000814 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 491915000815 tetramer interface [polypeptide binding]; other site 491915000816 active site 491915000817 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 491915000818 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 491915000819 ATP binding site [chemical binding]; other site 491915000820 active site 491915000821 substrate binding site [chemical binding]; other site 491915000822 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 491915000823 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 491915000824 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 491915000825 putative active site [active] 491915000826 catalytic triad [active] 491915000827 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 491915000828 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 491915000829 dimerization interface [polypeptide binding]; other site 491915000830 ATP binding site [chemical binding]; other site 491915000831 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 491915000832 dimerization interface [polypeptide binding]; other site 491915000833 ATP binding site [chemical binding]; other site 491915000834 amidophosphoribosyltransferase; Provisional; Region: PRK07631 491915000835 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 491915000836 active site 491915000837 tetramer interface [polypeptide binding]; other site 491915000838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915000839 active site 491915000840 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 491915000841 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 491915000842 dimerization interface [polypeptide binding]; other site 491915000843 putative ATP binding site [chemical binding]; other site 491915000844 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 491915000845 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 491915000846 active site 491915000847 substrate binding site [chemical binding]; other site 491915000848 cosubstrate binding site; other site 491915000849 catalytic site [active] 491915000850 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 491915000851 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 491915000852 purine monophosphate binding site [chemical binding]; other site 491915000853 dimer interface [polypeptide binding]; other site 491915000854 putative catalytic residues [active] 491915000855 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 491915000856 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 491915000857 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 491915000858 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 491915000859 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 491915000860 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 491915000861 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 491915000862 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 491915000863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 491915000864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 491915000865 active site 491915000866 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 491915000867 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 491915000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 491915000869 PcrB family; Region: PcrB; pfam01884 491915000870 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 491915000871 substrate binding site [chemical binding]; other site 491915000872 putative active site [active] 491915000873 dimer interface [polypeptide binding]; other site 491915000874 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 491915000875 Part of AAA domain; Region: AAA_19; pfam13245 491915000876 Family description; Region: UvrD_C_2; pfam13538 491915000877 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 491915000878 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 491915000879 nucleotide binding pocket [chemical binding]; other site 491915000880 K-X-D-G motif; other site 491915000881 catalytic site [active] 491915000882 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 491915000883 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 491915000884 Helix-hairpin-helix motif; Region: HHH; pfam00633 491915000885 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 491915000886 Dimer interface [polypeptide binding]; other site 491915000887 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 491915000888 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 491915000889 putative dimer interface [polypeptide binding]; other site 491915000890 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 491915000891 putative dimer interface [polypeptide binding]; other site 491915000892 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 491915000893 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 491915000894 Glutamate binding site [chemical binding]; other site 491915000895 homodimer interface [polypeptide binding]; other site 491915000896 NAD binding site [chemical binding]; other site 491915000897 catalytic residues [active] 491915000898 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 491915000899 active site 491915000900 NTP binding site [chemical binding]; other site 491915000901 metal binding triad [ion binding]; metal-binding site 491915000902 antibiotic binding site [chemical binding]; other site 491915000903 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 491915000904 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915000905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915000906 Winged helix-turn helix; Region: HTH_29; pfam13551 491915000907 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915000908 Homeodomain-like domain; Region: HTH_32; pfam13565 491915000909 Winged helix-turn helix; Region: HTH_33; pfam13592 491915000910 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915000911 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 491915000912 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 491915000913 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 491915000914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 491915000915 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 491915000916 active site 491915000917 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 491915000918 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 491915000919 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 491915000920 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 491915000921 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 491915000922 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 491915000923 GatB domain; Region: GatB_Yqey; pfam02637 491915000924 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 491915000925 putative active site [active] 491915000926 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 491915000927 NADPH bind site [chemical binding]; other site 491915000928 putative FMN binding site [chemical binding]; other site 491915000929 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 491915000930 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 491915000931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915000932 S-adenosylmethionine binding site [chemical binding]; other site 491915000933 ribonuclease Y; Region: RNase_Y; TIGR03319 491915000934 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 491915000935 TIGR02677 family protein; Region: TIGR02677 491915000936 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 491915000937 TIGR02680 family protein; Region: TIGR02680 491915000938 P-loop containing region of AAA domain; Region: AAA_29; cl17516 491915000939 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 491915000940 TIGR02679 family protein; Region: TIGR02679 491915000941 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 491915000942 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 491915000943 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 491915000944 NAD(P) binding site [chemical binding]; other site 491915000945 catalytic residues [active] 491915000946 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 491915000947 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 491915000948 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 491915000949 D-pathway; other site 491915000950 Putative ubiquinol binding site [chemical binding]; other site 491915000951 Low-spin heme (heme b) binding site [chemical binding]; other site 491915000952 Putative water exit pathway; other site 491915000953 Binuclear center (heme o3/CuB) [ion binding]; other site 491915000954 K-pathway; other site 491915000955 Putative proton exit pathway; other site 491915000956 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 491915000957 Subunit I/III interface [polypeptide binding]; other site 491915000958 Subunit III/IV interface [polypeptide binding]; other site 491915000959 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 491915000960 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 491915000961 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 491915000962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915000963 Zn2+ binding site [ion binding]; other site 491915000964 Mg2+ binding site [ion binding]; other site 491915000965 PspA/IM30 family; Region: PspA_IM30; pfam04012 491915000966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915000967 dimer interface [polypeptide binding]; other site 491915000968 phosphorylation site [posttranslational modification] 491915000969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915000970 ATP binding site [chemical binding]; other site 491915000971 Mg2+ binding site [ion binding]; other site 491915000972 G-X-G motif; other site 491915000973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915000974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915000975 active site 491915000976 phosphorylation site [posttranslational modification] 491915000977 intermolecular recognition site; other site 491915000978 dimerization interface [polypeptide binding]; other site 491915000979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 491915000980 DNA binding site [nucleotide binding] 491915000981 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 491915000982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915000983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 491915000984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915000985 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915000986 active site residue [active] 491915000987 PAS fold; Region: PAS; pfam00989 491915000988 PAS domain; Region: PAS_8; pfam13188 491915000989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 491915000990 Histidine kinase; Region: HisKA_3; pfam07730 491915000991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915000992 ATP binding site [chemical binding]; other site 491915000993 Mg2+ binding site [ion binding]; other site 491915000994 G-X-G motif; other site 491915000995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915000997 active site 491915000998 phosphorylation site [posttranslational modification] 491915000999 intermolecular recognition site; other site 491915001000 dimerization interface [polypeptide binding]; other site 491915001001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915001002 DNA binding residues [nucleotide binding] 491915001003 dimerization interface [polypeptide binding]; other site 491915001004 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 491915001005 putative lipid kinase; Reviewed; Region: PRK13337 491915001006 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 491915001007 TRAM domain; Region: TRAM; pfam01938 491915001008 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 491915001009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915001010 S-adenosylmethionine binding site [chemical binding]; other site 491915001011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915001013 putative substrate translocation pore; other site 491915001014 PAS domain; Region: PAS_9; pfam13426 491915001015 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915001016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915001017 dimer interface [polypeptide binding]; other site 491915001018 putative CheW interface [polypeptide binding]; other site 491915001019 Predicted transcriptional regulators [Transcription]; Region: COG1695 491915001020 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 491915001021 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 491915001022 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915001023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915001024 DNA binding residues [nucleotide binding] 491915001025 5' nucleotidase family; Region: 5_nucleotid; cl17687 491915001026 5' nucleotidase family; Region: 5_nucleotid; cl17687 491915001027 5' nucleotidase family; Region: 5_nucleotid; cl17687 491915001028 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 491915001029 active site 491915001030 dimer interface [polypeptide binding]; other site 491915001031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915001032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915001033 dimer interface [polypeptide binding]; other site 491915001034 putative CheW interface [polypeptide binding]; other site 491915001035 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 491915001036 NlpC/P60 family; Region: NLPC_P60; pfam00877 491915001037 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 491915001038 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 491915001039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915001040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915001041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 491915001042 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 491915001043 active site residue [active] 491915001044 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 491915001045 CPxP motif; other site 491915001046 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 491915001047 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 491915001048 active site 491915001049 metal binding site [ion binding]; metal-binding site 491915001050 FeoA domain; Region: FeoA; pfam04023 491915001051 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 491915001052 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 491915001053 G1 box; other site 491915001054 GTP/Mg2+ binding site [chemical binding]; other site 491915001055 Switch I region; other site 491915001056 G2 box; other site 491915001057 G3 box; other site 491915001058 Switch II region; other site 491915001059 G4 box; other site 491915001060 G5 box; other site 491915001061 Nucleoside recognition; Region: Gate; pfam07670 491915001062 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 491915001063 Nucleoside recognition; Region: Gate; pfam07670 491915001064 Acylphosphatase; Region: Acylphosphatase; pfam00708 491915001065 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 491915001066 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 491915001067 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 491915001068 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 491915001069 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 491915001070 putative active site [active] 491915001071 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 491915001072 putative active site [active] 491915001073 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 491915001074 active site 491915001075 SAM binding site [chemical binding]; other site 491915001076 homodimer interface [polypeptide binding]; other site 491915001077 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 491915001078 AAA domain; Region: AAA_18; pfam13238 491915001079 ligand-binding site [chemical binding]; other site 491915001080 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 491915001081 ATP-sulfurylase; Region: ATPS; cd00517 491915001082 active site 491915001083 HXXH motif; other site 491915001084 flexible loop; other site 491915001085 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 491915001086 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 491915001087 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 491915001088 Active Sites [active] 491915001089 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915001090 Zn2+ binding site [ion binding]; other site 491915001091 Mg2+ binding site [ion binding]; other site 491915001092 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 491915001093 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 491915001094 Low molecular weight phosphatase family; Region: LMWPc; cd00115 491915001095 active site 491915001096 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 491915001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915001098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915001099 putative substrate translocation pore; other site 491915001100 calcium/proton exchanger (cax); Region: cax; TIGR00378 491915001101 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 491915001102 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 491915001103 YfkD-like protein; Region: YfkD; pfam14167 491915001104 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 491915001105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915001106 FeS/SAM binding site; other site 491915001107 YfkB-like domain; Region: YfkB; pfam08756 491915001108 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 491915001109 Fumarase C-terminus; Region: Fumerase_C; pfam05683 491915001110 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 491915001111 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 491915001112 NodB motif; other site 491915001113 active site 491915001114 catalytic site [active] 491915001115 Cd binding site [ion binding]; other site 491915001116 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 491915001117 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 491915001118 minor groove reading motif; other site 491915001119 helix-hairpin-helix signature motif; other site 491915001120 substrate binding pocket [chemical binding]; other site 491915001121 active site 491915001122 TRAM domain; Region: TRAM; pfam01938 491915001123 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 491915001124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915001125 S-adenosylmethionine binding site [chemical binding]; other site 491915001126 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 491915001127 active site 491915001128 8-oxo-dGMP binding site [chemical binding]; other site 491915001129 nudix motif; other site 491915001130 metal binding site [ion binding]; metal-binding site 491915001131 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 491915001132 PLD-like domain; Region: PLDc_2; pfam13091 491915001133 putative active site [active] 491915001134 catalytic site [active] 491915001135 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 491915001136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915001137 ATP binding site [chemical binding]; other site 491915001138 putative Mg++ binding site [ion binding]; other site 491915001139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915001140 nucleotide binding region [chemical binding]; other site 491915001141 ATP-binding site [chemical binding]; other site 491915001142 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 491915001143 hypothetical protein; Validated; Region: PRK00029 491915001144 Uncharacterized conserved protein [Function unknown]; Region: COG0397 491915001145 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 491915001146 Probable transposase; Region: OrfB_IS605; pfam01385 491915001147 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915001148 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915001149 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 491915001150 putative switch regulator; other site 491915001151 non-specific DNA interactions [nucleotide binding]; other site 491915001152 DNA binding site [nucleotide binding] 491915001153 sequence specific DNA binding site [nucleotide binding]; other site 491915001154 putative cAMP binding site [chemical binding]; other site 491915001155 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 491915001156 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 491915001157 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 491915001158 NAD binding site [chemical binding]; other site 491915001159 substrate binding site [chemical binding]; other site 491915001160 catalytic Zn binding site [ion binding]; other site 491915001161 tetramer interface [polypeptide binding]; other site 491915001162 structural Zn binding site [ion binding]; other site 491915001163 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 491915001164 CHASE3 domain; Region: CHASE3; cl05000 491915001165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915001166 dimerization interface [polypeptide binding]; other site 491915001167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915001168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915001169 dimer interface [polypeptide binding]; other site 491915001170 putative CheW interface [polypeptide binding]; other site 491915001171 YfhD-like protein; Region: YfhD; pfam14151 491915001172 YfhE-like protein; Region: YfhE; pfam14152 491915001173 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 491915001174 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 491915001175 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 491915001176 active site 491915001177 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 491915001178 TIGR01777 family protein; Region: yfcH 491915001179 putative NAD(P) binding site [chemical binding]; other site 491915001180 putative active site [active] 491915001181 RecX family; Region: RecX; cl00936 491915001182 short chain dehydrogenase; Provisional; Region: PRK06924 491915001183 classical (c) SDRs; Region: SDR_c; cd05233 491915001184 NAD(P) binding site [chemical binding]; other site 491915001185 active site 491915001186 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 491915001187 L-lactate permease; Region: Lactate_perm; cl00701 491915001188 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 491915001189 YpzG-like protein; Region: YpzG; pfam14139 491915001190 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 491915001191 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 491915001192 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 491915001193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 491915001194 minor groove reading motif; other site 491915001195 helix-hairpin-helix signature motif; other site 491915001196 substrate binding pocket [chemical binding]; other site 491915001197 active site 491915001198 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 491915001199 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 491915001200 DNA binding and oxoG recognition site [nucleotide binding] 491915001201 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 491915001202 hypothetical protein; Provisional; Region: PRK13662 491915001203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 491915001204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 491915001205 Walker A/P-loop; other site 491915001206 ATP binding site [chemical binding]; other site 491915001207 Q-loop/lid; other site 491915001208 ABC transporter signature motif; other site 491915001209 Walker B; other site 491915001210 D-loop; other site 491915001211 H-loop/switch region; other site 491915001212 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 491915001213 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 491915001214 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 491915001215 Walker A/P-loop; other site 491915001216 ATP binding site [chemical binding]; other site 491915001217 Q-loop/lid; other site 491915001218 ABC transporter signature motif; other site 491915001219 Walker B; other site 491915001220 D-loop; other site 491915001221 H-loop/switch region; other site 491915001222 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 491915001223 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 491915001224 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 491915001225 peptide binding site [polypeptide binding]; other site 491915001226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 491915001227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915001228 dimer interface [polypeptide binding]; other site 491915001229 conserved gate region; other site 491915001230 putative PBP binding loops; other site 491915001231 ABC-ATPase subunit interface; other site 491915001232 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 491915001233 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 491915001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915001235 dimer interface [polypeptide binding]; other site 491915001236 conserved gate region; other site 491915001237 ABC-ATPase subunit interface; other site 491915001238 Predicted membrane protein [Function unknown]; Region: COG4129 491915001239 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 491915001240 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 491915001241 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 491915001242 active site 491915001243 dimer interface [polypeptide binding]; other site 491915001244 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 491915001245 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 491915001246 active site 491915001247 FMN binding site [chemical binding]; other site 491915001248 substrate binding site [chemical binding]; other site 491915001249 3Fe-4S cluster binding site [ion binding]; other site 491915001250 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 491915001251 domain_subunit interface; other site 491915001252 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 491915001253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915001254 inhibitor-cofactor binding pocket; inhibition site 491915001255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915001256 catalytic residue [active] 491915001257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 491915001258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915001259 Walker A/P-loop; other site 491915001260 ATP binding site [chemical binding]; other site 491915001261 Q-loop/lid; other site 491915001262 ABC transporter signature motif; other site 491915001263 Walker B; other site 491915001264 D-loop; other site 491915001265 H-loop/switch region; other site 491915001266 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 491915001267 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 491915001268 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 491915001269 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 491915001270 Ion channel; Region: Ion_trans_2; pfam07885 491915001271 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 491915001272 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915001273 catalytic triad [active] 491915001274 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 491915001275 metal binding site 2 [ion binding]; metal-binding site 491915001276 putative DNA binding helix; other site 491915001277 metal binding site 1 [ion binding]; metal-binding site 491915001278 dimer interface [polypeptide binding]; other site 491915001279 structural Zn2+ binding site [ion binding]; other site 491915001280 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 491915001281 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 491915001282 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 491915001283 glycogen branching enzyme; Provisional; Region: PRK12313 491915001284 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 491915001285 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 491915001286 active site 491915001287 catalytic site [active] 491915001288 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 491915001289 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 491915001290 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 491915001291 ligand binding site; other site 491915001292 oligomer interface; other site 491915001293 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 491915001294 dimer interface [polypeptide binding]; other site 491915001295 N-terminal domain interface [polypeptide binding]; other site 491915001296 sulfate 1 binding site; other site 491915001297 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 491915001298 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 491915001299 ligand binding site; other site 491915001300 oligomer interface; other site 491915001301 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 491915001302 dimer interface [polypeptide binding]; other site 491915001303 N-terminal domain interface [polypeptide binding]; other site 491915001304 sulfate 1 binding site; other site 491915001305 glycogen synthase; Provisional; Region: glgA; PRK00654 491915001306 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 491915001307 ADP-binding pocket [chemical binding]; other site 491915001308 homodimer interface [polypeptide binding]; other site 491915001309 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 491915001310 homodimer interface [polypeptide binding]; other site 491915001311 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 491915001312 active site pocket [active] 491915001313 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 491915001314 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 491915001315 UbiA prenyltransferase family; Region: UbiA; pfam01040 491915001316 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 491915001317 isochorismate synthases; Region: isochor_syn; TIGR00543 491915001318 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 491915001319 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 491915001320 dimer interface [polypeptide binding]; other site 491915001321 tetramer interface [polypeptide binding]; other site 491915001322 PYR/PP interface [polypeptide binding]; other site 491915001323 TPP binding site [chemical binding]; other site 491915001324 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 491915001325 TPP-binding site; other site 491915001326 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 491915001327 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 491915001328 nucleophilic elbow; other site 491915001329 catalytic triad; other site 491915001330 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 491915001331 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 491915001332 substrate binding site [chemical binding]; other site 491915001333 oxyanion hole (OAH) forming residues; other site 491915001334 trimer interface [polypeptide binding]; other site 491915001335 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 491915001336 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 491915001337 acyl-activating enzyme (AAE) consensus motif; other site 491915001338 putative AMP binding site [chemical binding]; other site 491915001339 putative active site [active] 491915001340 putative CoA binding site [chemical binding]; other site 491915001341 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 491915001342 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 491915001343 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 491915001344 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 491915001345 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 491915001346 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 491915001347 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 491915001348 dimer interface [polypeptide binding]; other site 491915001349 putative radical transfer pathway; other site 491915001350 diiron center [ion binding]; other site 491915001351 tyrosyl radical; other site 491915001352 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 491915001353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915001354 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915001355 Probable transposase; Region: OrfB_IS605; pfam01385 491915001356 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915001357 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 491915001358 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 491915001359 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 491915001360 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 491915001361 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 491915001362 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 491915001363 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 491915001364 metal binding site [ion binding]; metal-binding site 491915001365 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 491915001366 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 491915001367 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 491915001368 Haemolytic domain; Region: Haemolytic; pfam01809 491915001369 S-ribosylhomocysteinase; Provisional; Region: PRK02260 491915001370 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 491915001371 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 491915001372 dimerization interface [polypeptide binding]; other site 491915001373 DPS ferroxidase diiron center [ion binding]; other site 491915001374 ion pore; other site 491915001375 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 491915001376 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 491915001377 nudix motif; other site 491915001378 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 491915001379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915001380 dimer interface [polypeptide binding]; other site 491915001381 conserved gate region; other site 491915001382 putative PBP binding loops; other site 491915001383 ABC-ATPase subunit interface; other site 491915001384 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 491915001385 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 491915001386 Walker A/P-loop; other site 491915001387 ATP binding site [chemical binding]; other site 491915001388 Q-loop/lid; other site 491915001389 ABC transporter signature motif; other site 491915001390 Walker B; other site 491915001391 D-loop; other site 491915001392 H-loop/switch region; other site 491915001393 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 491915001394 NMT1-like family; Region: NMT1_2; pfam13379 491915001395 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 491915001396 Fatty acid desaturase; Region: FA_desaturase; pfam00487 491915001397 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 491915001398 putative di-iron ligands [ion binding]; other site 491915001399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 491915001400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915001401 Walker A/P-loop; other site 491915001402 ATP binding site [chemical binding]; other site 491915001403 Q-loop/lid; other site 491915001404 ABC transporter signature motif; other site 491915001405 Walker B; other site 491915001406 D-loop; other site 491915001407 H-loop/switch region; other site 491915001408 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 491915001409 cobalt transport protein CbiM; Validated; Region: PRK06265 491915001410 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 491915001411 PDGLE domain; Region: PDGLE; pfam13190 491915001412 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 491915001413 substrate binding site [chemical binding]; other site 491915001414 amidase catalytic site [active] 491915001415 Zn binding residues [ion binding]; other site 491915001416 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 491915001417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915001418 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 491915001419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 491915001420 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 491915001421 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 491915001422 active site 491915001423 substrate-binding site [chemical binding]; other site 491915001424 metal-binding site [ion binding] 491915001425 ATP binding site [chemical binding]; other site 491915001426 S-adenosylmethionine synthetase; Validated; Region: PRK05250 491915001427 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 491915001428 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 491915001429 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 491915001430 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 491915001431 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 491915001432 active site 491915001433 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 491915001434 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 491915001435 trimer interface [polypeptide binding]; other site 491915001436 putative metal binding site [ion binding]; other site 491915001437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 491915001438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 491915001439 Serine hydrolase; Region: Ser_hydrolase; cl17834 491915001440 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 491915001441 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 491915001442 putative active site [active] 491915001443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 491915001444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 491915001445 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 491915001446 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 491915001447 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 491915001448 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 491915001449 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 491915001450 HIGH motif; other site 491915001451 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 491915001452 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 491915001453 active site 491915001454 KMSKS motif; other site 491915001455 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 491915001456 tRNA binding surface [nucleotide binding]; other site 491915001457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915001458 active site residue [active] 491915001459 HI0933-like protein; Region: HI0933_like; pfam03486 491915001460 stage V sporulation protein B; Region: spore_V_B; TIGR02900 491915001461 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 491915001462 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 491915001463 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 491915001464 active site 491915001465 uracil binding [chemical binding]; other site 491915001466 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 491915001467 dipeptidase PepV; Reviewed; Region: PRK07318 491915001468 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 491915001469 active site 491915001470 metal binding site [ion binding]; metal-binding site 491915001471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915001472 sugar efflux transporter; Region: 2A0120; TIGR00899 491915001473 putative substrate translocation pore; other site 491915001474 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 491915001475 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 491915001476 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 491915001477 holin-like protein; Validated; Region: PRK01658 491915001478 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 491915001479 pullulanase, type I; Region: pulA_typeI; TIGR02104 491915001480 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 491915001481 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 491915001482 Ca binding site [ion binding]; other site 491915001483 active site 491915001484 catalytic site [active] 491915001485 Phosphotransferase enzyme family; Region: APH; pfam01636 491915001486 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 491915001487 substrate binding site [chemical binding]; other site 491915001488 YtzH-like protein; Region: YtzH; pfam14165 491915001489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915001490 S-adenosylmethionine binding site [chemical binding]; other site 491915001491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915001492 Predicted small secreted protein [Function unknown]; Region: COG5584 491915001493 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 491915001494 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 491915001495 oligomer interface [polypeptide binding]; other site 491915001496 active site 491915001497 metal binding site [ion binding]; metal-binding site 491915001498 NTPase; Reviewed; Region: PRK03114 491915001499 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 491915001500 catalytic residues [active] 491915001501 hypothetical protein; Provisional; Region: PRK13668 491915001502 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 491915001503 putative tRNA-binding site [nucleotide binding]; other site 491915001504 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 491915001505 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 491915001506 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 491915001507 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 491915001508 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 491915001509 active site 491915001510 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 491915001511 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 491915001512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 491915001513 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 491915001514 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 491915001515 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 491915001516 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 491915001517 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 491915001518 cell division protein FtsA; Region: ftsA; TIGR01174 491915001519 Cell division protein FtsA; Region: FtsA; smart00842 491915001520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 491915001521 nucleotide binding site [chemical binding]; other site 491915001522 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 491915001523 Chorismate mutase type II; Region: CM_2; cl00693 491915001524 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 491915001525 catabolite control protein A; Region: ccpA; TIGR01481 491915001526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915001527 DNA binding site [nucleotide binding] 491915001528 domain linker motif; other site 491915001529 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 491915001530 dimerization interface [polypeptide binding]; other site 491915001531 effector binding site; other site 491915001532 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 491915001533 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 491915001534 active site 491915001535 Zn binding site [ion binding]; other site 491915001536 FOG: CBS domain [General function prediction only]; Region: COG0517 491915001537 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 491915001538 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 491915001539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915001540 Coenzyme A binding pocket [chemical binding]; other site 491915001541 acetyl-CoA synthetase; Provisional; Region: PRK04319 491915001542 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 491915001543 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 491915001544 active site 491915001545 acyl-activating enzyme (AAE) consensus motif; other site 491915001546 putative CoA binding site [chemical binding]; other site 491915001547 AMP binding site [chemical binding]; other site 491915001548 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 491915001549 Transglycosylase; Region: Transgly; pfam00912 491915001550 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 491915001551 anticodon binding site; other site 491915001552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 491915001553 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 491915001554 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 491915001555 active site 491915001556 HIGH motif; other site 491915001557 dimer interface [polypeptide binding]; other site 491915001558 KMSKS motif; other site 491915001559 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915001560 RNA binding surface [nucleotide binding]; other site 491915001561 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 491915001562 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 491915001563 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915001564 RNA binding surface [nucleotide binding]; other site 491915001565 GAF domain; Region: GAF_3; pfam13492 491915001566 GAF domain; Region: GAF_2; pfam13185 491915001567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915001568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915001569 metal binding site [ion binding]; metal-binding site 491915001570 active site 491915001571 I-site; other site 491915001572 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 491915001573 GAF domain; Region: GAF_2; pfam13185 491915001574 histidinol-phosphatase; Reviewed; Region: PRK08123 491915001575 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 491915001576 active site 491915001577 dimer interface [polypeptide binding]; other site 491915001578 septation ring formation regulator EzrA; Provisional; Region: PRK04778 491915001579 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 491915001580 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 491915001581 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 491915001582 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915001583 catalytic residue [active] 491915001584 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 491915001585 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 491915001586 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 491915001587 Ligand Binding Site [chemical binding]; other site 491915001588 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 491915001589 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 491915001590 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 491915001591 active site 491915001592 acyl-activating enzyme (AAE) consensus motif; other site 491915001593 putative CoA binding site [chemical binding]; other site 491915001594 AMP binding site [chemical binding]; other site 491915001595 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 491915001596 ATP-NAD kinase; Region: NAD_kinase; pfam01513 491915001597 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 491915001598 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 491915001599 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 491915001600 dimer interface [polypeptide binding]; other site 491915001601 catalytic triad [active] 491915001602 peroxidatic and resolving cysteines [active] 491915001603 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 491915001604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915001605 S-adenosylmethionine binding site [chemical binding]; other site 491915001606 propionate/acetate kinase; Provisional; Region: PRK12379 491915001607 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 491915001608 argininosuccinate synthase; Provisional; Region: PRK13820 491915001609 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 491915001610 ANP binding site [chemical binding]; other site 491915001611 Substrate Binding Site II [chemical binding]; other site 491915001612 Substrate Binding Site I [chemical binding]; other site 491915001613 argininosuccinate lyase; Provisional; Region: PRK00855 491915001614 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 491915001615 active sites [active] 491915001616 tetramer interface [polypeptide binding]; other site 491915001617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 491915001618 Ligand Binding Site [chemical binding]; other site 491915001619 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 491915001620 classical (c) SDRs; Region: SDR_c; cd05233 491915001621 NAD(P) binding site [chemical binding]; other site 491915001622 active site 491915001623 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 491915001624 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 491915001625 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 491915001626 active site 491915001627 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 491915001628 metal-dependent hydrolase; Provisional; Region: PRK00685 491915001629 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 491915001630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915001631 DNA-binding site [nucleotide binding]; DNA binding site 491915001632 DRTGG domain; Region: DRTGG; pfam07085 491915001633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 491915001634 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 491915001635 active site 2 [active] 491915001636 active site 1 [active] 491915001637 YtpI-like protein; Region: YtpI; pfam14007 491915001638 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 491915001639 DHH family; Region: DHH; pfam01368 491915001640 DHHA1 domain; Region: DHHA1; pfam02272 491915001641 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 491915001642 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 491915001643 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 491915001644 active site 491915001645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 491915001646 generic binding surface II; other site 491915001647 generic binding surface I; other site 491915001648 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 491915001649 Malic enzyme, N-terminal domain; Region: malic; pfam00390 491915001650 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 491915001651 putative NAD(P) binding site [chemical binding]; other site 491915001652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915001653 DNA-binding site [nucleotide binding]; DNA binding site 491915001654 Transcriptional regulators [Transcription]; Region: FadR; COG2186 491915001655 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 491915001656 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 491915001657 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 491915001658 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 491915001659 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 491915001660 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 491915001661 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 491915001662 active site 491915001663 ADP/pyrophosphate binding site [chemical binding]; other site 491915001664 dimerization interface [polypeptide binding]; other site 491915001665 allosteric effector site; other site 491915001666 fructose-1,6-bisphosphate binding site; other site 491915001667 pyruvate kinase; Provisional; Region: PRK06354 491915001668 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 491915001669 domain interfaces; other site 491915001670 active site 491915001671 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 491915001672 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 491915001673 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 491915001674 Domain of unknown function DUF20; Region: UPF0118; pfam01594 491915001675 Protein of unknown function (DUF441); Region: DUF441; pfam04284 491915001676 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 491915001677 dimer interface [polypeptide binding]; other site 491915001678 Citrate synthase; Region: Citrate_synt; pfam00285 491915001679 active site 491915001680 citrylCoA binding site [chemical binding]; other site 491915001681 oxalacetate/citrate binding site [chemical binding]; other site 491915001682 coenzyme A binding site [chemical binding]; other site 491915001683 catalytic triad [active] 491915001684 isocitrate dehydrogenase; Reviewed; Region: PRK07006 491915001685 isocitrate dehydrogenase; Validated; Region: PRK07362 491915001686 malate dehydrogenase; Reviewed; Region: PRK06223 491915001687 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 491915001688 NAD(P) binding site [chemical binding]; other site 491915001689 dimer interface [polypeptide binding]; other site 491915001690 tetramer (dimer of dimers) interface [polypeptide binding]; other site 491915001691 substrate binding site [chemical binding]; other site 491915001692 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 491915001693 active site 2 [active] 491915001694 active site 1 [active] 491915001695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915001697 active site 491915001698 phosphorylation site [posttranslational modification] 491915001699 intermolecular recognition site; other site 491915001700 dimerization interface [polypeptide binding]; other site 491915001701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 491915001702 DNA binding site [nucleotide binding] 491915001703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915001704 dimerization interface [polypeptide binding]; other site 491915001705 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 491915001706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915001707 putative active site [active] 491915001708 heme pocket [chemical binding]; other site 491915001709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915001710 dimer interface [polypeptide binding]; other site 491915001711 phosphorylation site [posttranslational modification] 491915001712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915001713 ATP binding site [chemical binding]; other site 491915001714 Mg2+ binding site [ion binding]; other site 491915001715 G-X-G motif; other site 491915001716 DNA polymerase I; Provisional; Region: PRK05755 491915001717 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 491915001718 active site 491915001719 metal binding site 1 [ion binding]; metal-binding site 491915001720 putative 5' ssDNA interaction site; other site 491915001721 metal binding site 3; metal-binding site 491915001722 metal binding site 2 [ion binding]; metal-binding site 491915001723 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 491915001724 putative DNA binding site [nucleotide binding]; other site 491915001725 putative metal binding site [ion binding]; other site 491915001726 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 491915001727 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 491915001728 active site 491915001729 DNA binding site [nucleotide binding] 491915001730 catalytic site [active] 491915001731 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 491915001732 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 491915001733 DNA binding site [nucleotide binding] 491915001734 catalytic residue [active] 491915001735 H2TH interface [polypeptide binding]; other site 491915001736 putative catalytic residues [active] 491915001737 turnover-facilitating residue; other site 491915001738 intercalation triad [nucleotide binding]; other site 491915001739 8OG recognition residue [nucleotide binding]; other site 491915001740 putative reading head residues; other site 491915001741 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 491915001742 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 491915001743 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 491915001744 Domain of unknown function DUF; Region: DUF204; pfam02659 491915001745 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 491915001746 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 491915001747 CoA-binding site [chemical binding]; other site 491915001748 ATP-binding [chemical binding]; other site 491915001749 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 491915001750 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 491915001751 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 491915001752 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 491915001753 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 491915001754 ATP cone domain; Region: ATP-cone; pfam03477 491915001755 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 491915001756 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 491915001757 primosomal protein DnaI; Reviewed; Region: PRK08939 491915001758 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 491915001759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915001760 Walker A motif; other site 491915001761 ATP binding site [chemical binding]; other site 491915001762 Walker B motif; other site 491915001763 YtxC-like family; Region: YtxC; cl08500 491915001764 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 491915001765 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 491915001766 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 491915001767 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 491915001768 active site 491915001769 dimer interface [polypeptide binding]; other site 491915001770 motif 1; other site 491915001771 motif 2; other site 491915001772 motif 3; other site 491915001773 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 491915001774 anticodon binding site; other site 491915001775 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 491915001776 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 491915001777 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 491915001778 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 491915001779 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 491915001780 23S rRNA binding site [nucleotide binding]; other site 491915001781 L21 binding site [polypeptide binding]; other site 491915001782 L13 binding site [polypeptide binding]; other site 491915001783 DDE superfamily endonuclease; Region: DDE_5; cl17874 491915001784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915001785 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 491915001786 dUTPase; Region: dUTPase_2; pfam08761 491915001787 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 491915001788 active site 491915001789 homodimer interface [polypeptide binding]; other site 491915001790 metal binding site [ion binding]; metal-binding site 491915001791 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 491915001792 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 491915001793 oligomer interface [polypeptide binding]; other site 491915001794 active site 491915001795 metal binding site [ion binding]; metal-binding site 491915001796 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 491915001797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915001798 DNA-binding site [nucleotide binding]; DNA binding site 491915001799 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 491915001800 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 491915001801 putative dimerization interface [polypeptide binding]; other site 491915001802 putative ligand binding site [chemical binding]; other site 491915001803 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 491915001804 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 491915001805 intersubunit interface [polypeptide binding]; other site 491915001806 active site 491915001807 Zn2+ binding site [ion binding]; other site 491915001808 ribulokinase; Provisional; Region: PRK04123 491915001809 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 491915001810 N- and C-terminal domain interface [polypeptide binding]; other site 491915001811 active site 491915001812 MgATP binding site [chemical binding]; other site 491915001813 catalytic site [active] 491915001814 metal binding site [ion binding]; metal-binding site 491915001815 carbohydrate binding site [chemical binding]; other site 491915001816 homodimer interface [polypeptide binding]; other site 491915001817 L-arabinose isomerase; Provisional; Region: PRK02929 491915001818 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 491915001819 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 491915001820 trimer interface [polypeptide binding]; other site 491915001821 putative substrate binding site [chemical binding]; other site 491915001822 putative metal binding site [ion binding]; other site 491915001823 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 491915001824 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 491915001825 active site 491915001826 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 491915001827 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 491915001828 C-terminal fragment of alpha-galactosidase 491915001829 authentic frameshift 491915001830 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 491915001831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915001832 DNA binding site [nucleotide binding] 491915001833 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 491915001834 putative dimerization interface [polypeptide binding]; other site 491915001835 putative ligand binding site [chemical binding]; other site 491915001836 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 491915001837 active site 491915001838 catalytic residues [active] 491915001839 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 491915001840 methionine sulfoxide reductase A; Provisional; Region: PRK14054 491915001841 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 491915001842 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 491915001843 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 491915001844 T-box leader; Aflv_R080 491915001845 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 491915001846 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 491915001847 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 491915001848 dimer interface [polypeptide binding]; other site 491915001849 motif 1; other site 491915001850 active site 491915001851 motif 2; other site 491915001852 motif 3; other site 491915001853 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 491915001854 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 491915001855 putative tRNA-binding site [nucleotide binding]; other site 491915001856 B3/4 domain; Region: B3_4; pfam03483 491915001857 tRNA synthetase B5 domain; Region: B5; smart00874 491915001858 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 491915001859 dimer interface [polypeptide binding]; other site 491915001860 motif 1; other site 491915001861 motif 3; other site 491915001862 motif 2; other site 491915001863 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 491915001864 Integrase core domain; Region: rve; pfam00665 491915001865 DDE domain; Region: DDE_Tnp_IS240; pfam13610 491915001866 Integrase core domain; Region: rve_3; cl15866 491915001867 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 491915001868 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 491915001869 Integrase core domain; Region: rve; pfam00665 491915001870 DDE domain; Region: DDE_Tnp_IS240; pfam13610 491915001871 Integrase core domain; Region: rve_3; cl15866 491915001872 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 491915001873 substrate binding pocket [chemical binding]; other site 491915001874 substrate-Mg2+ binding site; other site 491915001875 aspartate-rich region 1; other site 491915001876 aspartate-rich region 2; other site 491915001877 Bacillus competence pheromone ComX; Region: ComX; pfam05952 491915001878 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 491915001879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 491915001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915001881 ATP binding site [chemical binding]; other site 491915001882 Mg2+ binding site [ion binding]; other site 491915001883 G-X-G motif; other site 491915001884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915001885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915001886 active site 491915001887 phosphorylation site [posttranslational modification] 491915001888 intermolecular recognition site; other site 491915001889 dimerization interface [polypeptide binding]; other site 491915001890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915001891 DNA binding residues [nucleotide binding] 491915001892 dimerization interface [polypeptide binding]; other site 491915001893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 491915001894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 491915001895 VanZ like family; Region: VanZ; pfam04892 491915001896 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 491915001897 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 491915001898 putative active site [active] 491915001899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 491915001900 MarR family; Region: MarR_2; pfam12802 491915001901 MMPL family; Region: MMPL; pfam03176 491915001902 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915001903 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 491915001904 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 491915001905 cell division protein ZapA; Provisional; Region: PRK14126 491915001906 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 491915001907 Colicin V production protein; Region: Colicin_V; pfam02674 491915001908 hypothetical protein; Provisional; Region: PRK08609 491915001909 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 491915001910 active site 491915001911 primer binding site [nucleotide binding]; other site 491915001912 NTP binding site [chemical binding]; other site 491915001913 metal binding triad [ion binding]; metal-binding site 491915001914 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 491915001915 active site 491915001916 MutS domain III; Region: MutS_III; pfam05192 491915001917 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 491915001918 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 491915001919 Walker A/P-loop; other site 491915001920 ATP binding site [chemical binding]; other site 491915001921 Q-loop/lid; other site 491915001922 ABC transporter signature motif; other site 491915001923 Walker B; other site 491915001924 D-loop; other site 491915001925 H-loop/switch region; other site 491915001926 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 491915001927 Smr domain; Region: Smr; pfam01713 491915001928 Predicted membrane protein [Function unknown]; Region: COG3766 491915001929 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 491915001930 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 491915001931 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 491915001932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 491915001933 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 491915001934 acyl-activating enzyme (AAE) consensus motif; other site 491915001935 putative AMP binding site [chemical binding]; other site 491915001936 putative active site [active] 491915001937 putative CoA binding site [chemical binding]; other site 491915001938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915001939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915001940 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 491915001941 enoyl-CoA hydratase; Provisional; Region: PRK07658 491915001942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 491915001943 substrate binding site [chemical binding]; other site 491915001944 oxyanion hole (OAH) forming residues; other site 491915001945 trimer interface [polypeptide binding]; other site 491915001946 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 491915001947 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 491915001948 Ligand binding site [chemical binding]; other site 491915001949 Electron transfer flavoprotein domain; Region: ETF; pfam01012 491915001950 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 491915001951 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 491915001952 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 491915001953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 491915001954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915001955 catalytic residues [active] 491915001956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 491915001957 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 491915001958 NAD(P) binding site [chemical binding]; other site 491915001959 active site 491915001960 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 491915001961 Sulfatase; Region: Sulfatase; cl17466 491915001962 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 491915001963 Ligand binding site; other site 491915001964 Putative Catalytic site; other site 491915001965 DXD motif; other site 491915001966 Iron permease FTR1 family; Region: FTR1; cl00475 491915001967 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 491915001968 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 491915001969 GIY-YIG motif/motif A; other site 491915001970 active site 491915001971 catalytic site [active] 491915001972 putative DNA binding site [nucleotide binding]; other site 491915001973 metal binding site [ion binding]; metal-binding site 491915001974 UvrB/uvrC motif; Region: UVR; pfam02151 491915001975 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 491915001976 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 491915001977 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 491915001978 putative Iron-sulfur protein interface [polypeptide binding]; other site 491915001979 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 491915001980 proximal heme binding site [chemical binding]; other site 491915001981 distal heme binding site [chemical binding]; other site 491915001982 putative dimer interface [polypeptide binding]; other site 491915001983 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 491915001984 L-aspartate oxidase; Provisional; Region: PRK06175 491915001985 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 491915001986 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 491915001987 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 491915001988 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 491915001989 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 491915001990 active site 491915001991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915001992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915001993 DNA binding residues [nucleotide binding] 491915001994 dimerization interface [polypeptide binding]; other site 491915001995 glutamate racemase; Provisional; Region: PRK00865 491915001996 Sporulation and spore germination; Region: Germane; pfam10646 491915001997 Spore germination protein [General function prediction only]; Region: COG5401 491915001998 Sporulation and spore germination; Region: Germane; pfam10646 491915001999 ribonuclease PH; Reviewed; Region: rph; PRK00173 491915002000 Ribonuclease PH; Region: RNase_PH_bact; cd11362 491915002001 hexamer interface [polypeptide binding]; other site 491915002002 active site 491915002003 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 491915002004 active site 491915002005 dimerization interface [polypeptide binding]; other site 491915002006 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 491915002007 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 491915002008 active site 491915002009 metal binding site [ion binding]; metal-binding site 491915002010 homotetramer interface [polypeptide binding]; other site 491915002011 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 491915002012 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 491915002013 homodimer interface [polypeptide binding]; other site 491915002014 substrate-cofactor binding pocket; other site 491915002015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002016 catalytic residue [active] 491915002017 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 491915002018 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 491915002019 PYR/PP interface [polypeptide binding]; other site 491915002020 dimer interface [polypeptide binding]; other site 491915002021 TPP binding site [chemical binding]; other site 491915002022 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 491915002023 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 491915002024 TPP-binding site [chemical binding]; other site 491915002025 dimer interface [polypeptide binding]; other site 491915002026 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 491915002027 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 491915002028 putative valine binding site [chemical binding]; other site 491915002029 dimer interface [polypeptide binding]; other site 491915002030 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 491915002031 ketol-acid reductoisomerase; Provisional; Region: PRK05479 491915002032 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 491915002033 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 491915002034 2-isopropylmalate synthase; Validated; Region: PRK00915 491915002035 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 491915002036 active site 491915002037 catalytic residues [active] 491915002038 metal binding site [ion binding]; metal-binding site 491915002039 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 491915002040 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 491915002041 tartrate dehydrogenase; Region: TTC; TIGR02089 491915002042 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 491915002043 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 491915002044 substrate binding site [chemical binding]; other site 491915002045 ligand binding site [chemical binding]; other site 491915002046 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 491915002047 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 491915002048 substrate binding site [chemical binding]; other site 491915002049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915002050 binding surface 491915002051 Tetratricopeptide repeat; Region: TPR_16; pfam13432 491915002052 TPR motif; other site 491915002053 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 491915002054 trigger factor; Provisional; Region: tig; PRK01490 491915002055 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 491915002056 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 491915002057 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 491915002058 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 491915002059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002060 Walker A motif; other site 491915002061 ATP binding site [chemical binding]; other site 491915002062 Walker B motif; other site 491915002063 arginine finger; other site 491915002064 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 491915002065 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 491915002066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002067 Walker A motif; other site 491915002068 ATP binding site [chemical binding]; other site 491915002069 Walker B motif; other site 491915002070 arginine finger; other site 491915002071 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 491915002072 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 491915002073 Found in ATP-dependent protease La (LON); Region: LON; smart00464 491915002074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002075 Walker A motif; other site 491915002076 ATP binding site [chemical binding]; other site 491915002077 Walker B motif; other site 491915002078 arginine finger; other site 491915002079 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 491915002080 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 491915002081 G1 box; other site 491915002082 GTP/Mg2+ binding site [chemical binding]; other site 491915002083 Switch I region; other site 491915002084 G2 box; other site 491915002085 G3 box; other site 491915002086 Switch II region; other site 491915002087 G4 box; other site 491915002088 G5 box; other site 491915002089 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 491915002090 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 491915002091 tRNA; other site 491915002092 putative tRNA binding site [nucleotide binding]; other site 491915002093 putative NADP binding site [chemical binding]; other site 491915002094 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 491915002095 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 491915002096 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 491915002097 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 491915002098 domain interfaces; other site 491915002099 active site 491915002100 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 491915002101 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 491915002102 active site 491915002103 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 491915002104 dimer interface [polypeptide binding]; other site 491915002105 active site 491915002106 Schiff base residues; other site 491915002107 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 491915002108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915002109 inhibitor-cofactor binding pocket; inhibition site 491915002110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002111 catalytic residue [active] 491915002112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915002113 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 491915002114 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 491915002115 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 491915002116 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 491915002117 active site 491915002118 HIGH motif; other site 491915002119 nucleotide binding site [chemical binding]; other site 491915002120 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 491915002121 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 491915002122 active site 491915002123 KMSKS motif; other site 491915002124 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 491915002125 tRNA binding surface [nucleotide binding]; other site 491915002126 anticodon binding site; other site 491915002127 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 491915002128 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 491915002129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 491915002130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 491915002131 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 491915002132 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 491915002133 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 491915002134 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 491915002135 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 491915002136 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 491915002137 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 491915002138 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 491915002139 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 491915002140 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 491915002141 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 491915002142 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 491915002143 VanW like protein; Region: VanW; pfam04294 491915002144 G5 domain; Region: G5; pfam07501 491915002145 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 491915002146 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 491915002147 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 491915002148 Walker A motif; other site 491915002149 ATP binding site [chemical binding]; other site 491915002150 Walker B motif; other site 491915002151 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 491915002152 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 491915002153 Walker A motif; other site 491915002154 ATP binding site [chemical binding]; other site 491915002155 Walker B motif; other site 491915002156 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 491915002157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 491915002158 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 491915002159 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 491915002160 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 491915002161 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 491915002162 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 491915002163 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 491915002164 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 491915002165 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 491915002166 Sporulation related domain; Region: SPOR; cl10051 491915002167 Maf-like protein; Region: Maf; pfam02545 491915002168 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 491915002169 active site 491915002170 dimer interface [polypeptide binding]; other site 491915002171 DNA repair RadC protein N-terminus 491915002172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 491915002173 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 491915002174 catalytic residues [active] 491915002175 catalytic nucleophile [active] 491915002176 Recombinase; Region: Recombinase; pfam07508 491915002177 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 491915002178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915002179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915002180 sequence-specific DNA binding site [nucleotide binding]; other site 491915002181 salt bridge; other site 491915002182 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 491915002183 Catalytic site [active] 491915002184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915002185 non-specific DNA binding site [nucleotide binding]; other site 491915002186 salt bridge; other site 491915002187 sequence-specific DNA binding site [nucleotide binding]; other site 491915002188 ORF6N domain; Region: ORF6N; pfam10543 491915002189 Hypothetical protein Yqai; Region: Yqai; pfam09466 491915002190 VRR-NUC domain; Region: VRR_NUC; pfam08774 491915002191 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 491915002192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 491915002193 putative Mg++ binding site [ion binding]; other site 491915002194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915002195 nucleotide binding region [chemical binding]; other site 491915002196 ATP-binding site [chemical binding]; other site 491915002197 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 491915002198 AAA domain; Region: AAA_24; pfam13479 491915002199 Protein of unknown function (DUF669); Region: DUF669; pfam05037 491915002200 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 491915002201 active site 491915002202 metal-binding site 491915002203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 491915002204 active site 491915002205 homodimer interface [polypeptide binding]; other site 491915002206 metal binding site [ion binding]; metal-binding site 491915002207 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 491915002208 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 491915002209 nucleotide binding site [chemical binding]; other site 491915002210 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 491915002211 positive control sigma-like factor; Validated; Region: PRK06930 491915002212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915002213 DNA binding residues [nucleotide binding] 491915002214 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 491915002215 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 491915002216 active site 491915002217 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 491915002218 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 491915002219 Phage-related protein [Function unknown]; Region: COG4695; cl01923 491915002220 Phage head maturation protease [General function prediction only]; Region: COG3740 491915002221 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 491915002222 Phage capsid family; Region: Phage_capsid; pfam05065 491915002223 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 491915002224 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 491915002225 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 491915002226 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 491915002227 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 491915002228 Phage tail protein; Region: Sipho_tail; cl17486 491915002229 Haemolysin XhlA; Region: XhlA; pfam10779 491915002230 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 491915002231 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 491915002232 S-layer homology domain; Region: SLH; pfam00395 491915002233 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915002234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915002235 non-specific DNA binding site [nucleotide binding]; other site 491915002236 salt bridge; other site 491915002237 sequence-specific DNA binding site [nucleotide binding]; other site 491915002238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 491915002239 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 491915002240 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 491915002241 DNA repair protein RadC C-terminus 491915002242 rod shape-determining protein MreB; Provisional; Region: PRK13927 491915002243 MreB and similar proteins; Region: MreB_like; cd10225 491915002244 nucleotide binding site [chemical binding]; other site 491915002245 Mg binding site [ion binding]; other site 491915002246 putative protofilament interaction site [polypeptide binding]; other site 491915002247 RodZ interaction site [polypeptide binding]; other site 491915002248 rod shape-determining protein MreC; Provisional; Region: PRK13922 491915002249 rod shape-determining protein MreC; Region: MreC; pfam04085 491915002250 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 491915002251 septum formation inhibitor; Reviewed; Region: minC; PRK00513 491915002252 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 491915002253 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 491915002254 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 491915002255 Switch I; other site 491915002256 Switch II; other site 491915002257 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 491915002258 Peptidase family M23; Region: Peptidase_M23; pfam01551 491915002259 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 491915002260 active site 491915002261 putative substrate binding region [chemical binding]; other site 491915002262 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 491915002263 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 491915002264 hypothetical protein; Provisional; Region: PRK14553 491915002265 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 491915002266 GTPase CgtA; Reviewed; Region: obgE; PRK12297 491915002267 GTP1/OBG; Region: GTP1_OBG; pfam01018 491915002268 Obg GTPase; Region: Obg; cd01898 491915002269 G1 box; other site 491915002270 GTP/Mg2+ binding site [chemical binding]; other site 491915002271 Switch I region; other site 491915002272 G2 box; other site 491915002273 G3 box; other site 491915002274 Switch II region; other site 491915002275 G4 box; other site 491915002276 G5 box; other site 491915002277 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 491915002278 hypothetical protein; Provisional; Region: PRK04435 491915002279 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 491915002280 prephenate dehydratase; Provisional; Region: PRK11898 491915002281 Prephenate dehydratase; Region: PDT; pfam00800 491915002282 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 491915002283 putative L-Phe binding site [chemical binding]; other site 491915002284 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 491915002285 HTH domain; Region: HTH_11; pfam08279 491915002286 3H domain; Region: 3H; pfam02829 491915002287 cysteine desulfurase; Provisional; Region: PRK02948 491915002288 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 491915002289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915002290 catalytic residue [active] 491915002291 L-aspartate oxidase; Provisional; Region: PRK08071 491915002292 L-aspartate oxidase; Provisional; Region: PRK06175 491915002293 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 491915002294 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 491915002295 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 491915002296 dimerization interface [polypeptide binding]; other site 491915002297 active site 491915002298 quinolinate synthetase; Provisional; Region: PRK09375 491915002299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915002300 NAD synthetase; Provisional; Region: PRK13980 491915002301 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 491915002302 homodimer interface [polypeptide binding]; other site 491915002303 NAD binding pocket [chemical binding]; other site 491915002304 ATP binding pocket [chemical binding]; other site 491915002305 Mg binding site [ion binding]; other site 491915002306 active-site loop [active] 491915002307 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 491915002308 hypothetical protein; Validated; Region: PRK00110 491915002309 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 491915002310 BofC C-terminal domain; Region: BofC_C; pfam08955 491915002311 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 491915002312 RuvA N terminal domain; Region: RuvA_N; pfam01330 491915002313 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 491915002314 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 491915002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002316 Walker A motif; other site 491915002317 ATP binding site [chemical binding]; other site 491915002318 Walker B motif; other site 491915002319 arginine finger; other site 491915002320 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 491915002321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915002322 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915002323 Probable transposase; Region: OrfB_IS605; pfam01385 491915002324 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915002325 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 491915002326 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 491915002327 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 491915002328 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 491915002329 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 491915002330 Preprotein translocase subunit; Region: YajC; pfam02699 491915002331 Predicted membrane protein [Function unknown]; Region: COG2323 491915002332 stage V sporulation protein B; Region: spore_V_B; TIGR02900 491915002333 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 491915002334 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 491915002335 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 491915002336 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 491915002337 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 491915002338 Protein export membrane protein; Region: SecD_SecF; pfam02355 491915002339 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 491915002340 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 491915002341 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 491915002342 DHH family; Region: DHH; pfam01368 491915002343 DHHA1 domain; Region: DHHA1; pfam02272 491915002344 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 491915002345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915002346 active site 491915002347 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 491915002348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915002349 Zn2+ binding site [ion binding]; other site 491915002350 Mg2+ binding site [ion binding]; other site 491915002351 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 491915002352 synthetase active site [active] 491915002353 NTP binding site [chemical binding]; other site 491915002354 metal binding site [ion binding]; metal-binding site 491915002355 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 491915002356 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 491915002357 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 491915002358 putative active site [active] 491915002359 dimerization interface [polypeptide binding]; other site 491915002360 putative tRNAtyr binding site [nucleotide binding]; other site 491915002361 Bacterial SH3 domain; Region: SH3_3; pfam08239 491915002362 Bacterial SH3 domain; Region: SH3_3; pfam08239 491915002363 Bacterial SH3 domain; Region: SH3_3; pfam08239 491915002364 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 491915002365 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 491915002366 active site 491915002367 metal binding site [ion binding]; metal-binding site 491915002368 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 491915002369 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 491915002370 dimer interface [polypeptide binding]; other site 491915002371 motif 1; other site 491915002372 active site 491915002373 motif 2; other site 491915002374 motif 3; other site 491915002375 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 491915002376 anticodon binding site; other site 491915002377 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 491915002378 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 491915002379 dimer interface [polypeptide binding]; other site 491915002380 anticodon binding site; other site 491915002381 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 491915002382 homodimer interface [polypeptide binding]; other site 491915002383 motif 1; other site 491915002384 active site 491915002385 motif 2; other site 491915002386 GAD domain; Region: GAD; pfam02938 491915002387 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 491915002388 motif 3; other site 491915002389 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 491915002390 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 491915002391 putative ATP binding site [chemical binding]; other site 491915002392 putative substrate interface [chemical binding]; other site 491915002393 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 491915002394 Protein export membrane protein; Region: SecD_SecF; cl14618 491915002395 Protein export membrane protein; Region: SecD_SecF; cl14618 491915002396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915002397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915002398 recombination factor protein RarA; Reviewed; Region: PRK13342 491915002399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002400 Walker A motif; other site 491915002401 ATP binding site [chemical binding]; other site 491915002402 Walker B motif; other site 491915002403 arginine finger; other site 491915002404 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 491915002405 Predicted transcriptional regulator [Transcription]; Region: COG1959 491915002406 Transcriptional regulator; Region: Rrf2; pfam02082 491915002407 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 491915002408 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 491915002409 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915002410 catalytic residue [active] 491915002411 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 491915002412 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 491915002413 TPR repeat; Region: TPR_11; pfam13414 491915002414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915002415 binding surface 491915002416 TPR motif; other site 491915002417 TPR repeat; Region: TPR_11; pfam13414 491915002418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915002419 binding surface 491915002420 TPR motif; other site 491915002421 TPR repeat; Region: TPR_11; pfam13414 491915002422 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 491915002423 AAA domain; Region: AAA_30; pfam13604 491915002424 Family description; Region: UvrD_C_2; pfam13538 491915002425 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 491915002426 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 491915002427 Domain of unknown function DUF20; Region: UPF0118; pfam01594 491915002428 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 491915002429 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 491915002430 motif 1; other site 491915002431 active site 491915002432 motif 2; other site 491915002433 motif 3; other site 491915002434 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 491915002435 DHHA1 domain; Region: DHHA1; pfam02272 491915002436 hypothetical protein; Provisional; Region: PRK05473 491915002437 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 491915002438 hypothetical protein; Provisional; Region: PRK13678 491915002439 YceG-like family; Region: YceG; pfam02618 491915002440 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 491915002441 dimerization interface [polypeptide binding]; other site 491915002442 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 491915002443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915002444 S-adenosylmethionine binding site [chemical binding]; other site 491915002445 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 491915002446 Peptidase family U32; Region: Peptidase_U32; pfam01136 491915002447 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 491915002448 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 491915002449 Peptidase family U32; Region: Peptidase_U32; pfam01136 491915002450 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 491915002451 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 491915002452 Sugar specificity; other site 491915002453 Pyrimidine base specificity; other site 491915002454 ATP-binding site [chemical binding]; other site 491915002455 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 491915002456 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 491915002457 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 491915002458 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 491915002459 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 491915002460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 491915002461 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 491915002462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915002463 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 491915002464 Probable transposase; Region: OrfB_IS605; pfam01385 491915002465 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915002466 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 491915002467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915002468 S-adenosylmethionine binding site [chemical binding]; other site 491915002469 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 491915002470 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 491915002471 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 491915002472 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 491915002473 dimer interface [polypeptide binding]; other site 491915002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002475 catalytic residue [active] 491915002476 cystathionine beta-lyase; Provisional; Region: PRK07671 491915002477 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 491915002478 homodimer interface [polypeptide binding]; other site 491915002479 substrate-cofactor binding pocket; other site 491915002480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002481 catalytic residue [active] 491915002482 YrhC-like protein; Region: YrhC; pfam14143 491915002483 Staphylococcal nuclease homologues; Region: SNc; smart00318 491915002484 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 491915002485 Catalytic site; other site 491915002486 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 491915002487 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 491915002488 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 491915002489 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 491915002490 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 491915002491 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 491915002492 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 491915002493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 491915002494 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 491915002495 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 491915002496 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 491915002497 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 491915002498 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 491915002499 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 491915002500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915002501 Walker A motif; other site 491915002502 ATP binding site [chemical binding]; other site 491915002503 Walker B motif; other site 491915002504 arginine finger; other site 491915002505 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 491915002506 RNA polymerase sporulation-specific sigma factor (sigma-K) (C-terminal half) 491915002507 Domain of unknown function (DUF955); Region: DUF955; pfam06114 491915002508 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 491915002509 Restriction endonuclease; Region: Mrr_cat; pfam04471 491915002510 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915002511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915002512 non-specific DNA binding site [nucleotide binding]; other site 491915002513 salt bridge; other site 491915002514 sequence-specific DNA binding site [nucleotide binding]; other site 491915002515 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915002516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915002517 non-specific DNA binding site [nucleotide binding]; other site 491915002518 salt bridge; other site 491915002519 sequence-specific DNA binding site [nucleotide binding]; other site 491915002520 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 491915002521 polymerase nucleotide-binding site; other site 491915002522 DNA-binding residues [nucleotide binding]; DNA binding site 491915002523 nucleotide binding site [chemical binding]; other site 491915002524 primase nucleotide-binding site [nucleotide binding]; other site 491915002525 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 491915002526 D5 N terminal like; Region: D5_N; pfam08706 491915002527 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 491915002528 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 491915002529 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 491915002530 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 491915002531 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 491915002532 catalytic residues [active] 491915002533 catalytic nucleophile [active] 491915002534 Recombinase; Region: Recombinase; pfam07508 491915002535 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 491915002536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915002537 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 491915002538 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 491915002539 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 491915002540 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 491915002541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 491915002542 ligand binding site [chemical binding]; other site 491915002543 flagellar motor protein MotA; Validated; Region: PRK08124 491915002544 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 491915002545 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 491915002546 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 491915002547 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 491915002548 Sporulation inhibitor A; Region: Sda; pfam08970 491915002549 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 491915002550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915002551 active site 491915002552 motif I; other site 491915002553 motif II; other site 491915002554 GTPase YqeH; Provisional; Region: PRK13796 491915002555 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 491915002556 GTP/Mg2+ binding site [chemical binding]; other site 491915002557 G4 box; other site 491915002558 G5 box; other site 491915002559 G1 box; other site 491915002560 Switch I region; other site 491915002561 G2 box; other site 491915002562 G3 box; other site 491915002563 Switch II region; other site 491915002564 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 491915002565 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 491915002566 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 491915002567 shikimate binding site; other site 491915002568 NAD(P) binding site [chemical binding]; other site 491915002569 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 491915002570 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 491915002571 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 491915002572 active site 491915002573 (T/H)XGH motif; other site 491915002574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915002575 Zn2+ binding site [ion binding]; other site 491915002576 Mg2+ binding site [ion binding]; other site 491915002577 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 491915002578 Methyltransferase domain; Region: Methyltransf_31; pfam13847 491915002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915002580 S-adenosylmethionine binding site [chemical binding]; other site 491915002581 late competence protein ComER; Validated; Region: PRK07680 491915002582 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 491915002583 SLBB domain; Region: SLBB; pfam10531 491915002584 comEA protein; Region: comE; TIGR01259 491915002585 Helix-hairpin-helix motif; Region: HHH; pfam00633 491915002586 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 491915002587 catalytic motif [active] 491915002588 Zn binding site [ion binding]; other site 491915002589 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 491915002590 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 491915002591 Competence protein; Region: Competence; pfam03772 491915002592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915002593 YqzM-like protein; Region: YqzM; pfam14141 491915002594 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 491915002595 DNA polymerase III, delta subunit; Region: holA; TIGR01128 491915002596 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 491915002597 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 491915002598 ligand binding site [chemical binding]; other site 491915002599 flexible hinge region; other site 491915002600 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 491915002601 putative switch regulator; other site 491915002602 non-specific DNA interactions [nucleotide binding]; other site 491915002603 DNA binding site [nucleotide binding] 491915002604 sequence specific DNA binding site [nucleotide binding]; other site 491915002605 putative cAMP binding site [chemical binding]; other site 491915002606 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 491915002607 germination protease; Provisional; Region: PRK02858 491915002608 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 491915002609 stage II sporulation protein P; Region: spore_II_P; TIGR02867 491915002610 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 491915002611 GTP-binding protein LepA; Provisional; Region: PRK05433 491915002612 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 491915002613 G1 box; other site 491915002614 putative GEF interaction site [polypeptide binding]; other site 491915002615 GTP/Mg2+ binding site [chemical binding]; other site 491915002616 Switch I region; other site 491915002617 G2 box; other site 491915002618 G3 box; other site 491915002619 Switch II region; other site 491915002620 G4 box; other site 491915002621 G5 box; other site 491915002622 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 491915002623 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 491915002624 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 491915002625 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 491915002626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915002627 FeS/SAM binding site; other site 491915002628 HemN C-terminal domain; Region: HemN_C; pfam06969 491915002629 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 491915002630 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 491915002631 GrpE; Region: GrpE; pfam01025 491915002632 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 491915002633 dimer interface [polypeptide binding]; other site 491915002634 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 491915002635 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 491915002636 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 491915002637 nucleotide binding site [chemical binding]; other site 491915002638 NEF interaction site [polypeptide binding]; other site 491915002639 SBD interface [polypeptide binding]; other site 491915002640 chaperone protein DnaJ; Provisional; Region: PRK14280 491915002641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 491915002642 HSP70 interaction site [polypeptide binding]; other site 491915002643 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 491915002644 substrate binding site [polypeptide binding]; other site 491915002645 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 491915002646 Zn binding sites [ion binding]; other site 491915002647 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 491915002648 dimer interface [polypeptide binding]; other site 491915002649 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 491915002650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915002651 S-adenosylmethionine binding site [chemical binding]; other site 491915002652 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 491915002653 RNA methyltransferase, RsmE family; Region: TIGR00046 491915002654 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 491915002655 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 491915002656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915002657 FeS/SAM binding site; other site 491915002658 TRAM domain; Region: TRAM; cl01282 491915002659 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 491915002660 Yqey-like protein; Region: YqeY; pfam09424 491915002661 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 491915002662 hypothetical protein; Provisional; Region: PRK13665 491915002663 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 491915002664 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 491915002665 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 491915002666 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 491915002667 PhoH-like protein; Region: PhoH; pfam02562 491915002668 metal-binding heat shock protein; Provisional; Region: PRK00016 491915002669 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 491915002670 GTPase Era; Reviewed; Region: era; PRK00089 491915002671 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 491915002672 G1 box; other site 491915002673 GTP/Mg2+ binding site [chemical binding]; other site 491915002674 Switch I region; other site 491915002675 G2 box; other site 491915002676 Switch II region; other site 491915002677 G3 box; other site 491915002678 G4 box; other site 491915002679 G5 box; other site 491915002680 KH domain; Region: KH_2; pfam07650 491915002681 YqzL-like protein; Region: YqzL; pfam14006 491915002682 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 491915002683 Recombination protein O N terminal; Region: RecO_N; pfam11967 491915002684 Recombination protein O C terminal; Region: RecO_C; pfam02565 491915002685 HTH domain; Region: HTH_11; pfam08279 491915002686 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 491915002687 FOG: CBS domain [General function prediction only]; Region: COG0517 491915002688 PEP synthetase regulatory protein; Provisional; Region: PRK05339 491915002689 DNA primase; Validated; Region: dnaG; PRK05667 491915002690 CHC2 zinc finger; Region: zf-CHC2; pfam01807 491915002691 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 491915002692 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 491915002693 active site 491915002694 metal binding site [ion binding]; metal-binding site 491915002695 interdomain interaction site; other site 491915002696 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 491915002697 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 491915002698 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 491915002699 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 491915002700 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 491915002701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915002702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 491915002703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915002704 DNA binding residues [nucleotide binding] 491915002705 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 491915002706 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 491915002707 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 491915002708 Family of unknown function (DUF633); Region: DUF633; pfam04816 491915002709 Uncharacterized conserved protein [Function unknown]; Region: COG0327 491915002710 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 491915002711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 491915002712 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 491915002713 Uncharacterized conserved protein [Function unknown]; Region: COG0327 491915002714 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 491915002715 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 491915002716 YqfQ-like protein; Region: YqfQ; pfam14181 491915002717 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 491915002718 DEAD-like helicases superfamily; Region: DEXDc; smart00487 491915002719 ATP binding site [chemical binding]; other site 491915002720 Mg++ binding site [ion binding]; other site 491915002721 motif III; other site 491915002722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915002723 nucleotide binding region [chemical binding]; other site 491915002724 ATP-binding site [chemical binding]; other site 491915002725 endonuclease IV; Provisional; Region: PRK01060 491915002726 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 491915002727 AP (apurinic/apyrimidinic) site pocket; other site 491915002728 DNA interaction; other site 491915002729 Metal-binding active site; metal-binding site 491915002730 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 491915002731 Uncharacterized conserved protein [Function unknown]; Region: COG1284 491915002732 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915002733 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915002734 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 491915002735 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 491915002736 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 491915002737 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 491915002738 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915002739 ABC-ATPase subunit interface; other site 491915002740 dimer interface [polypeptide binding]; other site 491915002741 putative PBP binding regions; other site 491915002742 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 491915002743 metal binding site 2 [ion binding]; metal-binding site 491915002744 putative DNA binding helix; other site 491915002745 metal binding site 1 [ion binding]; metal-binding site 491915002746 dimer interface [polypeptide binding]; other site 491915002747 structural Zn2+ binding site [ion binding]; other site 491915002748 Uncharacterized conserved protein [Function unknown]; Region: COG5663 491915002749 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 491915002750 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 491915002751 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 491915002752 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915002753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915002754 dimerization interface [polypeptide binding]; other site 491915002755 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915002756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915002757 dimer interface [polypeptide binding]; other site 491915002758 putative CheW interface [polypeptide binding]; other site 491915002759 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 491915002760 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 491915002761 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 491915002762 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 491915002763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915002764 putative substrate translocation pore; other site 491915002765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915002766 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 491915002767 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 491915002768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 491915002769 PBP superfamily domain; Region: PBP_like_2; cl17296 491915002770 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 491915002771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915002772 dimer interface [polypeptide binding]; other site 491915002773 conserved gate region; other site 491915002774 putative PBP binding loops; other site 491915002775 ABC-ATPase subunit interface; other site 491915002776 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 491915002777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915002778 dimer interface [polypeptide binding]; other site 491915002779 conserved gate region; other site 491915002780 putative PBP binding loops; other site 491915002781 ABC-ATPase subunit interface; other site 491915002782 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 491915002783 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 491915002784 Walker A/P-loop; other site 491915002785 ATP binding site [chemical binding]; other site 491915002786 Q-loop/lid; other site 491915002787 ABC transporter signature motif; other site 491915002788 Walker B; other site 491915002789 D-loop; other site 491915002790 H-loop/switch region; other site 491915002791 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 491915002792 PhoU domain; Region: PhoU; pfam01895 491915002793 PhoU domain; Region: PhoU; pfam01895 491915002794 YceG-like family; Region: YceG; pfam02618 491915002795 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 491915002796 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 491915002797 active site 491915002798 Substrate binding site; other site 491915002799 Mg++ binding site; other site 491915002800 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 491915002801 putative trimer interface [polypeptide binding]; other site 491915002802 putative CoA binding site [chemical binding]; other site 491915002803 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 491915002804 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 491915002805 active site 491915002806 substrate binding site [chemical binding]; other site 491915002807 metal binding site [ion binding]; metal-binding site 491915002808 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 491915002809 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 491915002810 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 491915002811 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 491915002812 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 491915002813 tetramer (dimer of dimers) interface [polypeptide binding]; other site 491915002814 NAD binding site [chemical binding]; other site 491915002815 dimer interface [polypeptide binding]; other site 491915002816 substrate binding site [chemical binding]; other site 491915002817 Rhomboid family; Region: Rhomboid; pfam01694 491915002818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915002819 binding surface 491915002820 TPR motif; other site 491915002821 TPR repeat; Region: TPR_11; pfam13414 491915002822 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915002823 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 491915002824 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 491915002825 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 491915002826 nucleotide binding site [chemical binding]; other site 491915002827 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 491915002828 Sulfatase; Region: Sulfatase; pfam00884 491915002829 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 491915002830 putative active site [active] 491915002831 Zn binding site [ion binding]; other site 491915002832 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 491915002833 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 491915002834 Uncharacterized conserved protein [Function unknown]; Region: COG1565 491915002835 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 491915002836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915002837 putative DNA binding site [nucleotide binding]; other site 491915002838 dimerization interface [polypeptide binding]; other site 491915002839 Predicted transcriptional regulator [Transcription]; Region: COG2345 491915002840 putative Zn2+ binding site [ion binding]; other site 491915002841 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 491915002842 ArsC family; Region: ArsC; pfam03960 491915002843 putative catalytic residues [active] 491915002844 thiol/disulfide switch; other site 491915002845 Type II/IV secretion system protein; Region: T2SE; pfam00437 491915002846 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 491915002847 Walker A motif; other site 491915002848 ATP binding site [chemical binding]; other site 491915002849 Walker B motif; other site 491915002850 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 491915002851 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 491915002852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 491915002853 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 491915002854 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 491915002855 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 491915002856 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 491915002857 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 491915002858 ComG operon protein 7; Region: ComGG; pfam14173 491915002859 shikimate kinase; Reviewed; Region: aroK; PRK00131 491915002860 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 491915002861 ADP binding site [chemical binding]; other site 491915002862 magnesium binding site [ion binding]; other site 491915002863 putative shikimate binding site; other site 491915002864 YqzE-like protein; Region: YqzE; pfam14038 491915002865 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 491915002866 DEAD-like helicases superfamily; Region: DEXDc; smart00487 491915002867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915002868 ATP binding site [chemical binding]; other site 491915002869 putative Mg++ binding site [ion binding]; other site 491915002870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915002871 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 491915002872 nucleotide binding region [chemical binding]; other site 491915002873 ATP-binding site [chemical binding]; other site 491915002874 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 491915002875 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 491915002876 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 491915002877 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 491915002878 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 491915002879 tetramer interface [polypeptide binding]; other site 491915002880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002881 catalytic residue [active] 491915002882 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 491915002883 tetramer interface [polypeptide binding]; other site 491915002884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915002885 catalytic residue [active] 491915002886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915002887 active site residue [active] 491915002888 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 491915002889 authentic frameshift 491915002890 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 491915002891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915002892 FeS/SAM binding site; other site 491915002893 manganese transport transcriptional regulator; Provisional; Region: PRK03902 491915002894 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 491915002895 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 491915002896 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 491915002897 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 491915002898 active site 491915002899 nucleophile elbow; other site 491915002900 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 491915002901 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 491915002902 Conserved membrane protein YqhR; Region: YqhR; pfam11085 491915002903 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 491915002904 Dehydroquinase class II; Region: DHquinase_II; pfam01220 491915002905 active site 491915002906 trimer interface [polypeptide binding]; other site 491915002907 dimer interface [polypeptide binding]; other site 491915002908 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 491915002909 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 491915002910 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 491915002911 active site 491915002912 elongation factor P; Validated; Region: PRK00529 491915002913 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 491915002914 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 491915002915 RNA binding site [nucleotide binding]; other site 491915002916 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 491915002917 RNA binding site [nucleotide binding]; other site 491915002918 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 491915002919 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 491915002920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 491915002921 Walker A motif; other site 491915002922 ATP binding site [chemical binding]; other site 491915002923 Walker B motif; other site 491915002924 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 491915002925 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 491915002926 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 491915002927 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 491915002928 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 491915002929 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 491915002930 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 491915002931 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 491915002932 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 491915002933 carboxyltransferase (CT) interaction site; other site 491915002934 biotinylation site [posttranslational modification]; other site 491915002935 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 491915002936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915002937 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 491915002938 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 491915002939 Asp23 family; Region: Asp23; pfam03780 491915002940 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 491915002941 putative RNA binding site [nucleotide binding]; other site 491915002942 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 491915002943 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 491915002944 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 491915002945 homodimer interface [polypeptide binding]; other site 491915002946 NADP binding site [chemical binding]; other site 491915002947 substrate binding site [chemical binding]; other site 491915002948 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 491915002949 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 491915002950 generic binding surface II; other site 491915002951 generic binding surface I; other site 491915002952 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 491915002953 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 491915002954 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 491915002955 substrate binding pocket [chemical binding]; other site 491915002956 chain length determination region; other site 491915002957 substrate-Mg2+ binding site; other site 491915002958 catalytic residues [active] 491915002959 aspartate-rich region 1; other site 491915002960 active site lid residues [active] 491915002961 aspartate-rich region 2; other site 491915002962 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 491915002963 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 491915002964 TPP-binding site; other site 491915002965 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 491915002966 PYR/PP interface [polypeptide binding]; other site 491915002967 dimer interface [polypeptide binding]; other site 491915002968 TPP binding site [chemical binding]; other site 491915002969 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 491915002970 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 491915002971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915002972 RNA binding surface [nucleotide binding]; other site 491915002973 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 491915002974 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 491915002975 arginine repressor; Provisional; Region: PRK04280 491915002976 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 491915002977 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 491915002978 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 491915002979 Walker A/P-loop; other site 491915002980 ATP binding site [chemical binding]; other site 491915002981 Q-loop/lid; other site 491915002982 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 491915002983 ABC transporter signature motif; other site 491915002984 Walker B; other site 491915002985 D-loop; other site 491915002986 H-loop/switch region; other site 491915002987 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 491915002988 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 491915002989 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 491915002990 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 491915002991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915002992 active site 491915002993 phosphorylation site [posttranslational modification] 491915002994 intermolecular recognition site; other site 491915002995 dimerization interface [polypeptide binding]; other site 491915002996 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 491915002997 YycC-like protein; Region: YycC; pfam14174 491915002998 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 491915002999 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 491915003000 active site 491915003001 catalytic site [active] 491915003002 metal binding site [ion binding]; metal-binding site 491915003003 dimer interface [polypeptide binding]; other site 491915003004 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 491915003005 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 491915003006 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 491915003007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915003008 putative active site [active] 491915003009 heme pocket [chemical binding]; other site 491915003010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915003011 putative active site [active] 491915003012 heme pocket [chemical binding]; other site 491915003013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915003014 Walker A motif; other site 491915003015 ATP binding site [chemical binding]; other site 491915003016 Walker B motif; other site 491915003017 arginine finger; other site 491915003018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 491915003019 phosphate butyryltransferase; Validated; Region: PRK07742 491915003020 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 491915003021 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 491915003022 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 491915003023 NAD binding site [chemical binding]; other site 491915003024 Phe binding site; other site 491915003025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 491915003026 nucleotide binding site [chemical binding]; other site 491915003027 Acetokinase family; Region: Acetate_kinase; cl17229 491915003028 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 491915003029 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 491915003030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915003031 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 491915003032 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 491915003033 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 491915003034 tetramer interface [polypeptide binding]; other site 491915003035 TPP-binding site [chemical binding]; other site 491915003036 heterodimer interface [polypeptide binding]; other site 491915003037 phosphorylation loop region [posttranslational modification] 491915003038 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 491915003039 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 491915003040 alpha subunit interface [polypeptide binding]; other site 491915003041 TPP binding site [chemical binding]; other site 491915003042 heterodimer interface [polypeptide binding]; other site 491915003043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 491915003044 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 491915003045 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 491915003046 E3 interaction surface; other site 491915003047 lipoyl attachment site [posttranslational modification]; other site 491915003048 e3 binding domain; Region: E3_binding; pfam02817 491915003049 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 491915003050 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 491915003051 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 491915003052 heterodimer interface [polypeptide binding]; other site 491915003053 substrate interaction site [chemical binding]; other site 491915003054 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 491915003055 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 491915003056 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 491915003057 active site 491915003058 substrate binding site [chemical binding]; other site 491915003059 coenzyme B12 binding site [chemical binding]; other site 491915003060 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 491915003061 B12 binding site [chemical binding]; other site 491915003062 cobalt ligand [ion binding]; other site 491915003063 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 491915003064 GTP/Mg2+ binding site [chemical binding]; other site 491915003065 membrane ATPase/protein kinase; Provisional; Region: PRK09435 491915003066 G5 box; other site 491915003067 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 491915003068 Walker A; other site 491915003069 G1 box; other site 491915003070 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 491915003071 Predicted membrane protein [Function unknown]; Region: COG4129 491915003072 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 491915003073 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 491915003074 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 491915003075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 491915003076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 491915003077 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 491915003078 dimer interface [polypeptide binding]; other site 491915003079 substrate binding site [chemical binding]; other site 491915003080 metal binding site [ion binding]; metal-binding site 491915003081 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 491915003082 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 491915003083 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 491915003084 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 491915003085 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 491915003086 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 491915003087 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 491915003088 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 491915003089 peptidase T-like protein; Region: PepT-like; TIGR01883 491915003090 metal binding site [ion binding]; metal-binding site 491915003091 putative dimer interface [polypeptide binding]; other site 491915003092 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 491915003093 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 491915003094 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 491915003095 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 491915003096 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 491915003097 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 491915003098 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 491915003099 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 491915003100 ribonuclease Z; Region: RNase_Z; TIGR02651 491915003101 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 491915003102 CHY zinc finger; Region: zf-CHY; pfam05495 491915003103 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 491915003104 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 491915003105 active site 491915003106 FMN binding site [chemical binding]; other site 491915003107 substrate binding site [chemical binding]; other site 491915003108 homotetramer interface [polypeptide binding]; other site 491915003109 catalytic residue [active] 491915003110 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 491915003111 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 491915003112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915003113 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 491915003114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 491915003115 NAD(P) binding site [chemical binding]; other site 491915003116 active site 491915003117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 491915003118 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 491915003119 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 491915003120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 491915003121 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 491915003122 active site 491915003123 catalytic tetrad [active] 491915003124 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 491915003125 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 491915003126 dimer interface [polypeptide binding]; other site 491915003127 ADP-ribose binding site [chemical binding]; other site 491915003128 active site 491915003129 nudix motif; other site 491915003130 metal binding site [ion binding]; metal-binding site 491915003131 stage II sporulation protein M; Region: spo_II_M; TIGR02831 491915003132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915003133 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915003134 Probable transposase; Region: OrfB_IS605; pfam01385 491915003135 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915003136 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915003137 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 491915003138 metal binding site 2 [ion binding]; metal-binding site 491915003139 putative DNA binding helix; other site 491915003140 metal binding site 1 [ion binding]; metal-binding site 491915003141 dimer interface [polypeptide binding]; other site 491915003142 structural Zn2+ binding site [ion binding]; other site 491915003143 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 491915003144 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 491915003145 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 491915003146 active site 491915003147 Int/Topo IB signature motif; other site 491915003148 phosphopentomutase; Provisional; Region: PRK05362 491915003149 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 491915003150 purine nucleoside phosphorylase; Provisional; Region: PRK08202 491915003151 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 491915003152 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 491915003153 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 491915003154 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 491915003155 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 491915003156 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 491915003157 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 491915003158 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 491915003159 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 491915003160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915003161 ATP binding site [chemical binding]; other site 491915003162 Mg2+ binding site [ion binding]; other site 491915003163 G-X-G motif; other site 491915003164 sporulation sigma factor SigF; Validated; Region: PRK05572 491915003165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915003166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 491915003167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915003168 DNA binding residues [nucleotide binding] 491915003169 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 491915003170 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 491915003171 SpoVA protein; Region: SpoVA; cl04298 491915003172 stage V sporulation protein AD; Validated; Region: PRK08304 491915003173 stage V sporulation protein AD; Provisional; Region: PRK12404 491915003174 SpoVA protein; Region: SpoVA; cl04298 491915003175 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 491915003176 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915003177 diaminopimelate decarboxylase; Region: lysA; TIGR01048 491915003178 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 491915003179 active site 491915003180 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 491915003181 substrate binding site [chemical binding]; other site 491915003182 catalytic residues [active] 491915003183 dimer interface [polypeptide binding]; other site 491915003184 Predicted secreted protein [Function unknown]; Region: COG4086 491915003185 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 491915003186 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 491915003187 active site 491915003188 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 491915003189 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 491915003190 catalytic motif [active] 491915003191 Zn binding site [ion binding]; other site 491915003192 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 491915003193 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 491915003194 Lumazine binding domain; Region: Lum_binding; pfam00677 491915003195 Lumazine binding domain; Region: Lum_binding; pfam00677 491915003196 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 491915003197 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 491915003198 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 491915003199 dimerization interface [polypeptide binding]; other site 491915003200 active site 491915003201 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 491915003202 homopentamer interface [polypeptide binding]; other site 491915003203 active site 491915003204 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 491915003205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915003206 Coenzyme A binding pocket [chemical binding]; other site 491915003207 Domain of unknown function (DUF309); Region: DUF309; pfam03745 491915003208 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 491915003209 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 491915003210 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 491915003211 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 491915003212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915003213 catalytic residue [active] 491915003214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915003215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915003216 putative substrate translocation pore; other site 491915003217 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 491915003218 hypothetical protein; Provisional; Region: PRK07206 491915003219 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 491915003220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915003221 putative DNA binding site [nucleotide binding]; other site 491915003222 dimerization interface [polypeptide binding]; other site 491915003223 putative Zn2+ binding site [ion binding]; other site 491915003224 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 491915003225 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 491915003226 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 491915003227 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 491915003228 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 491915003229 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 491915003230 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 491915003231 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 491915003232 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 491915003233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915003234 RNA binding surface [nucleotide binding]; other site 491915003235 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 491915003236 active site 491915003237 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 491915003238 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915003239 catalytic residues [active] 491915003240 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 491915003241 ResB-like family; Region: ResB; pfam05140 491915003242 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 491915003243 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 491915003244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915003245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915003246 active site 491915003247 phosphorylation site [posttranslational modification] 491915003248 intermolecular recognition site; other site 491915003249 dimerization interface [polypeptide binding]; other site 491915003250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 491915003251 DNA binding site [nucleotide binding] 491915003252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 491915003253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915003254 dimerization interface [polypeptide binding]; other site 491915003255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915003256 dimer interface [polypeptide binding]; other site 491915003257 phosphorylation site [posttranslational modification] 491915003258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915003259 ATP binding site [chemical binding]; other site 491915003260 Mg2+ binding site [ion binding]; other site 491915003261 G-X-G motif; other site 491915003262 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 491915003263 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 491915003264 putative binding site residues; other site 491915003265 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 491915003266 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915003267 ABC-ATPase subunit interface; other site 491915003268 dimer interface [polypeptide binding]; other site 491915003269 putative PBP binding regions; other site 491915003270 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 491915003271 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 491915003272 Walker A/P-loop; other site 491915003273 ATP binding site [chemical binding]; other site 491915003274 Q-loop/lid; other site 491915003275 ABC transporter signature motif; other site 491915003276 Walker B; other site 491915003277 D-loop; other site 491915003278 H-loop/switch region; other site 491915003279 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 491915003280 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 491915003281 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 491915003282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003284 homodimer interface [polypeptide binding]; other site 491915003285 catalytic residue [active] 491915003286 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 491915003287 homotrimer interface [polypeptide binding]; other site 491915003288 Walker A motif; other site 491915003289 GTP binding site [chemical binding]; other site 491915003290 Walker B motif; other site 491915003291 cobalamin synthase; Reviewed; Region: cobS; PRK00235 491915003292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 491915003293 catalytic core [active] 491915003294 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 491915003295 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 491915003296 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 491915003297 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 491915003298 histidinol-phosphatase; Provisional; Region: PRK07328 491915003299 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 491915003300 active site 491915003301 dimer interface [polypeptide binding]; other site 491915003302 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 491915003303 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 491915003304 ligand binding site [chemical binding]; other site 491915003305 NAD binding site [chemical binding]; other site 491915003306 dimerization interface [polypeptide binding]; other site 491915003307 catalytic site [active] 491915003308 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 491915003309 putative L-serine binding site [chemical binding]; other site 491915003310 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 491915003311 dimer interface [polypeptide binding]; other site 491915003312 substrate binding site [chemical binding]; other site 491915003313 metal binding sites [ion binding]; metal-binding site 491915003314 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 491915003315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 491915003316 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 491915003317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915003318 ATP binding site [chemical binding]; other site 491915003319 putative Mg++ binding site [ion binding]; other site 491915003320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915003321 nucleotide binding region [chemical binding]; other site 491915003322 ATP-binding site [chemical binding]; other site 491915003323 CAAX protease self-immunity; Region: Abi; pfam02517 491915003324 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 491915003325 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915003326 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 491915003327 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 491915003328 putative active site [active] 491915003329 putative metal binding site [ion binding]; other site 491915003330 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 491915003331 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 491915003332 DNA binding residues [nucleotide binding] 491915003333 B12 binding domain; Region: B12-binding_2; pfam02607 491915003334 B12 binding domain; Region: B12-binding; pfam02310 491915003335 B12 binding site [chemical binding]; other site 491915003336 adaptor protein; Provisional; Region: PRK02899 491915003337 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 491915003338 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 491915003339 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 491915003340 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 491915003341 NAD(P) binding site [chemical binding]; other site 491915003342 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 491915003343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 491915003344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915003345 AAA domain; Region: AAA_26; pfam13500 491915003346 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915003347 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 491915003348 ADP binding site [chemical binding]; other site 491915003349 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 491915003350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915003351 inhibitor-cofactor binding pocket; inhibition site 491915003352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003353 catalytic residue [active] 491915003354 germination protein YpeB; Region: spore_YpeB; TIGR02889 491915003355 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 491915003356 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 491915003357 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 491915003358 Protease prsW family; Region: PrsW-protease; pfam13367 491915003359 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 491915003360 Flagellar protein YcgR; Region: YcgR_2; pfam12945 491915003361 PilZ domain; Region: PilZ; pfam07238 491915003362 cytidylate kinase; Provisional; Region: cmk; PRK00023 491915003363 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 491915003364 CMP-binding site; other site 491915003365 The sites determining sugar specificity; other site 491915003366 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 491915003367 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 491915003368 putative acyl-acceptor binding pocket; other site 491915003369 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 491915003370 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 491915003371 RNA binding site [nucleotide binding]; other site 491915003372 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 491915003373 RNA binding site [nucleotide binding]; other site 491915003374 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 491915003375 RNA binding site [nucleotide binding]; other site 491915003376 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 491915003377 RNA binding site [nucleotide binding]; other site 491915003378 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 491915003379 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 491915003380 homotetramer interface [polypeptide binding]; other site 491915003381 FMN binding site [chemical binding]; other site 491915003382 homodimer contacts [polypeptide binding]; other site 491915003383 putative active site [active] 491915003384 putative substrate binding site [chemical binding]; other site 491915003385 YIEGIA protein; Region: YIEGIA; pfam14045 491915003386 GTP-binding protein Der; Reviewed; Region: PRK00093 491915003387 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 491915003388 G1 box; other site 491915003389 GTP/Mg2+ binding site [chemical binding]; other site 491915003390 Switch I region; other site 491915003391 G2 box; other site 491915003392 Switch II region; other site 491915003393 G3 box; other site 491915003394 G4 box; other site 491915003395 G5 box; other site 491915003396 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 491915003397 G1 box; other site 491915003398 GTP/Mg2+ binding site [chemical binding]; other site 491915003399 Switch I region; other site 491915003400 G2 box; other site 491915003401 G3 box; other site 491915003402 Switch II region; other site 491915003403 G4 box; other site 491915003404 G5 box; other site 491915003405 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 491915003406 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 491915003407 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 491915003408 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 491915003409 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 491915003410 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 491915003411 G1 box; other site 491915003412 GTP/Mg2+ binding site [chemical binding]; other site 491915003413 G2 box; other site 491915003414 Switch I region; other site 491915003415 G3 box; other site 491915003416 Switch II region; other site 491915003417 G5 box; other site 491915003418 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 491915003419 IHF dimer interface [polypeptide binding]; other site 491915003420 IHF - DNA interface [nucleotide binding]; other site 491915003421 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 491915003422 homodecamer interface [polypeptide binding]; other site 491915003423 GTP cyclohydrolase I; Provisional; Region: PLN03044 491915003424 active site 491915003425 putative catalytic site residues [active] 491915003426 zinc binding site [ion binding]; other site 491915003427 GTP-CH-I/GFRP interaction surface; other site 491915003428 transcription attenuation protein MtrB; Provisional; Region: PRK13251 491915003429 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 491915003430 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 491915003431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915003432 S-adenosylmethionine binding site [chemical binding]; other site 491915003433 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 491915003434 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 491915003435 substrate binding pocket [chemical binding]; other site 491915003436 chain length determination region; other site 491915003437 substrate-Mg2+ binding site; other site 491915003438 catalytic residues [active] 491915003439 aspartate-rich region 1; other site 491915003440 active site lid residues [active] 491915003441 aspartate-rich region 2; other site 491915003442 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 491915003443 active site 491915003444 multimer interface [polypeptide binding]; other site 491915003445 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 491915003446 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 491915003447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915003448 S-adenosylmethionine binding site [chemical binding]; other site 491915003449 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 491915003450 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 491915003451 Tetramer interface [polypeptide binding]; other site 491915003452 active site 491915003453 FMN-binding site [chemical binding]; other site 491915003454 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 491915003455 active site 491915003456 dimer interface [polypeptide binding]; other site 491915003457 metal binding site [ion binding]; metal-binding site 491915003458 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 491915003459 homotrimer interaction site [polypeptide binding]; other site 491915003460 active site 491915003461 anthranilate synthase component I; Provisional; Region: PRK13569 491915003462 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 491915003463 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 491915003464 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 491915003465 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 491915003466 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 491915003467 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 491915003468 active site 491915003469 ribulose/triose binding site [chemical binding]; other site 491915003470 phosphate binding site [ion binding]; other site 491915003471 substrate (anthranilate) binding pocket [chemical binding]; other site 491915003472 product (indole) binding pocket [chemical binding]; other site 491915003473 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 491915003474 active site 491915003475 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 491915003476 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 491915003477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003478 catalytic residue [active] 491915003479 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 491915003480 substrate binding site [chemical binding]; other site 491915003481 active site 491915003482 catalytic residues [active] 491915003483 heterodimer interface [polypeptide binding]; other site 491915003484 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 491915003485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915003486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003487 homodimer interface [polypeptide binding]; other site 491915003488 catalytic residue [active] 491915003489 prephenate dehydrogenase; Validated; Region: PRK06545 491915003490 prephenate dehydrogenase; Validated; Region: PRK08507 491915003491 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 491915003492 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 491915003493 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 491915003494 hinge; other site 491915003495 active site 491915003496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915003497 binding surface 491915003498 TPR motif; other site 491915003499 TPR repeat; Region: TPR_11; pfam13414 491915003500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915003501 TPR motif; other site 491915003502 binding surface 491915003503 TPR repeat; Region: TPR_11; pfam13414 491915003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915003505 binding surface 491915003506 TPR motif; other site 491915003507 hypothetical protein; Provisional; Region: PRK03636 491915003508 UPF0302 domain; Region: UPF0302; pfam08864 491915003509 IDEAL domain; Region: IDEAL; pfam08858 491915003510 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 491915003511 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 491915003512 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 491915003513 iron-sulfur cluster [ion binding]; other site 491915003514 [2Fe-2S] cluster binding site [ion binding]; other site 491915003515 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 491915003516 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 491915003517 interchain domain interface [polypeptide binding]; other site 491915003518 intrachain domain interface; other site 491915003519 heme bH binding site [chemical binding]; other site 491915003520 Qi binding site; other site 491915003521 heme bL binding site [chemical binding]; other site 491915003522 Qo binding site; other site 491915003523 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 491915003524 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 491915003525 interchain domain interface [polypeptide binding]; other site 491915003526 intrachain domain interface; other site 491915003527 Qi binding site; other site 491915003528 Qo binding site; other site 491915003529 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 491915003530 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 491915003531 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 491915003532 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 491915003533 Uncharacterized conserved protein [Function unknown]; Region: COG1284 491915003534 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915003535 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915003536 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 491915003537 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 491915003538 homodimer interface [polypeptide binding]; other site 491915003539 metal binding site [ion binding]; metal-binding site 491915003540 dihydrodipicolinate reductase; Provisional; Region: PRK00048 491915003541 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 491915003542 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 491915003543 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 491915003544 active site 491915003545 dimer interfaces [polypeptide binding]; other site 491915003546 catalytic residues [active] 491915003547 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 491915003548 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 491915003549 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 491915003550 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 491915003551 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 491915003552 active site 491915003553 NTP binding site [chemical binding]; other site 491915003554 metal binding triad [ion binding]; metal-binding site 491915003555 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 491915003556 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 491915003557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915003558 putative DNA binding site [nucleotide binding]; other site 491915003559 putative Zn2+ binding site [ion binding]; other site 491915003560 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 491915003561 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 491915003562 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 491915003563 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 491915003564 oligomerization interface [polypeptide binding]; other site 491915003565 active site 491915003566 metal binding site [ion binding]; metal-binding site 491915003567 pantoate--beta-alanine ligase; Region: panC; TIGR00018 491915003568 Pantoate-beta-alanine ligase; Region: PanC; cd00560 491915003569 active site 491915003570 ATP-binding site [chemical binding]; other site 491915003571 pantoate-binding site; other site 491915003572 HXXH motif; other site 491915003573 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 491915003574 tetramerization interface [polypeptide binding]; other site 491915003575 active site 491915003576 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 491915003577 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 491915003578 active site 491915003579 catalytic site [active] 491915003580 substrate binding site [chemical binding]; other site 491915003581 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 491915003582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 491915003583 putative Mg++ binding site [ion binding]; other site 491915003584 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 491915003585 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 491915003586 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 491915003587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 491915003588 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 491915003589 aspartate aminotransferase; Provisional; Region: PRK05764 491915003590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915003591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003592 homodimer interface [polypeptide binding]; other site 491915003593 catalytic residue [active] 491915003594 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 491915003595 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 491915003596 putative dimer interface [polypeptide binding]; other site 491915003597 putative anticodon binding site; other site 491915003598 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 491915003599 homodimer interface [polypeptide binding]; other site 491915003600 motif 1; other site 491915003601 motif 2; other site 491915003602 active site 491915003603 motif 3; other site 491915003604 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 491915003605 Helix-turn-helix domain; Region: HTH_36; pfam13730 491915003606 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 491915003607 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 491915003608 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 491915003609 minor groove reading motif; other site 491915003610 helix-hairpin-helix signature motif; other site 491915003611 substrate binding pocket [chemical binding]; other site 491915003612 active site 491915003613 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 491915003614 Transglycosylase; Region: Transgly; pfam00912 491915003615 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 491915003616 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 491915003617 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 491915003618 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 491915003619 putative transporter; Provisional; Region: PRK11660 491915003620 Sulfate transporter family; Region: Sulfate_transp; pfam00916 491915003621 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 491915003622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915003623 dimerization interface [polypeptide binding]; other site 491915003624 putative DNA binding site [nucleotide binding]; other site 491915003625 putative Zn2+ binding site [ion binding]; other site 491915003626 YppF-like protein; Region: YppF; pfam14178 491915003627 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 491915003628 YppG-like protein; Region: YppG; pfam14179 491915003629 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 491915003630 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 491915003631 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 491915003632 EcsC protein family; Region: EcsC; pfam12787 491915003633 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 491915003634 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 491915003635 putative dimer interface [polypeptide binding]; other site 491915003636 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 491915003637 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 491915003638 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915003639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915003640 metal binding site [ion binding]; metal-binding site 491915003641 active site 491915003642 I-site; other site 491915003643 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 491915003644 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 491915003645 glycerate kinase; Region: TIGR00045 491915003646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915003647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915003648 metal binding site [ion binding]; metal-binding site 491915003649 active site 491915003650 I-site; other site 491915003651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915003652 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 491915003653 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 491915003654 Walker A/P-loop; other site 491915003655 ATP binding site [chemical binding]; other site 491915003656 Q-loop/lid; other site 491915003657 ABC transporter signature motif; other site 491915003658 Walker B; other site 491915003659 D-loop; other site 491915003660 H-loop/switch region; other site 491915003661 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 491915003662 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 491915003663 putative ligand binding residues [chemical binding]; other site 491915003664 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 491915003665 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915003666 ABC-ATPase subunit interface; other site 491915003667 dimer interface [polypeptide binding]; other site 491915003668 putative PBP binding regions; other site 491915003669 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 491915003670 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915003671 ABC-ATPase subunit interface; other site 491915003672 dimer interface [polypeptide binding]; other site 491915003673 putative PBP binding regions; other site 491915003674 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 491915003675 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 491915003676 substrate-cofactor binding pocket; other site 491915003677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003678 catalytic residue [active] 491915003679 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 491915003680 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 491915003681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915003682 S-adenosylmethionine binding site [chemical binding]; other site 491915003683 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 491915003684 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 491915003685 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 491915003686 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 491915003687 TrkA-N domain; Region: TrkA_N; pfam02254 491915003688 TrkA-C domain; Region: TrkA_C; pfam02080 491915003689 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 491915003690 metal binding site [ion binding]; metal-binding site 491915003691 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 491915003692 PLD-like domain; Region: PLDc_2; pfam13091 491915003693 putative homodimer interface [polypeptide binding]; other site 491915003694 putative active site [active] 491915003695 catalytic site [active] 491915003696 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 491915003697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915003698 ATP binding site [chemical binding]; other site 491915003699 putative Mg++ binding site [ion binding]; other site 491915003700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915003701 nucleotide binding region [chemical binding]; other site 491915003702 ATP-binding site [chemical binding]; other site 491915003703 Winged helix-turn helix; Region: HTH_29; pfam13551 491915003704 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915003705 Protein of unknown function DUF91; Region: DUF91; cl00709 491915003706 hypothetical protein; Region: PHA00728 491915003707 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915003708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915003709 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915003710 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 491915003711 Part of AAA domain; Region: AAA_19; pfam13245 491915003712 Family description; Region: UvrD_C_2; pfam13538 491915003713 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 491915003714 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 491915003715 DNA methylase; Region: N6_N4_Mtase; pfam01555 491915003716 AAA domain; Region: AAA_30; pfam13604 491915003717 AAA domain; Region: AAA_11; pfam13086 491915003718 AAA domain; Region: AAA_12; pfam13087 491915003719 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 491915003720 Double zinc ribbon; Region: DZR; pfam12773 491915003721 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 491915003722 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 491915003723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915003724 Transposase; Region: HTH_Tnp_1; pfam01527 491915003725 HTH-like domain; Region: HTH_21; pfam13276 491915003726 Integrase core domain; Region: rve; pfam00665 491915003727 Cupin domain; Region: Cupin_2; cl17218 491915003728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 491915003729 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 491915003730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 491915003731 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 491915003732 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 491915003733 active site pocket [active] 491915003734 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 491915003735 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915003736 NAD binding site [chemical binding]; other site 491915003737 catalytic residues [active] 491915003738 substrate binding site [chemical binding]; other site 491915003739 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 491915003740 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 491915003741 tetramer interface [polypeptide binding]; other site 491915003742 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 491915003743 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915003744 NAD(P) binding site [chemical binding]; other site 491915003745 catalytic residues [active] 491915003746 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 491915003747 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 491915003748 NAD binding site [chemical binding]; other site 491915003749 catalytic Zn binding site [ion binding]; other site 491915003750 substrate binding site [chemical binding]; other site 491915003751 structural Zn binding site [ion binding]; other site 491915003752 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 491915003753 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 491915003754 active site 491915003755 metal binding site [ion binding]; metal-binding site 491915003756 BCCT family transporter; Region: BCCT; pfam02028 491915003757 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 491915003758 Integrase core domain; Region: rve; pfam00665 491915003759 DDE domain; Region: DDE_Tnp_IS240; pfam13610 491915003760 Integrase core domain; Region: rve_3; cl15866 491915003761 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 491915003762 DNA methylase; Region: N6_N4_Mtase; pfam01555 491915003763 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 491915003764 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 491915003765 authentic frameshift 491915003766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915003767 TPR motif; other site 491915003768 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 491915003769 Peptidase family M28; Region: Peptidase_M28; pfam04389 491915003770 metal binding site [ion binding]; metal-binding site 491915003771 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 491915003772 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 491915003773 active site 491915003774 NTP binding site [chemical binding]; other site 491915003775 metal binding triad [ion binding]; metal-binding site 491915003776 antibiotic binding site [chemical binding]; other site 491915003777 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 491915003778 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 491915003779 dimer interface [polypeptide binding]; other site 491915003780 active site 491915003781 heme binding site [chemical binding]; other site 491915003782 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 491915003783 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 491915003784 maltose O-acetyltransferase; Provisional; Region: PRK10092 491915003785 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 491915003786 active site 491915003787 substrate binding site [chemical binding]; other site 491915003788 trimer interface [polypeptide binding]; other site 491915003789 CoA binding site [chemical binding]; other site 491915003790 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 491915003791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915003792 FeS/SAM binding site; other site 491915003793 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 491915003794 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915003795 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 491915003796 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 491915003797 Spore germination protein; Region: Spore_permease; cl17796 491915003798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 491915003799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 491915003800 active site 491915003801 catalytic tetrad [active] 491915003802 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 491915003803 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 491915003804 NodB motif; other site 491915003805 active site 491915003806 catalytic site [active] 491915003807 metal binding site [ion binding]; metal-binding site 491915003808 authentic frameshift 491915003809 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 491915003810 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 491915003811 substrate binding [chemical binding]; other site 491915003812 active site 491915003813 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 491915003814 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 491915003815 putative homodimer interface [polypeptide binding]; other site 491915003816 putative homotetramer interface [polypeptide binding]; other site 491915003817 allosteric switch controlling residues; other site 491915003818 putative metal binding site [ion binding]; other site 491915003819 putative homodimer-homodimer interface [polypeptide binding]; other site 491915003820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 491915003821 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 491915003822 metal-binding site [ion binding] 491915003823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 491915003824 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 491915003825 metal-binding site [ion binding] 491915003826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 491915003827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915003828 motif II; other site 491915003829 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 491915003830 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 491915003831 metal-binding site [ion binding] 491915003832 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 491915003833 metal-binding site [ion binding] 491915003834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915003835 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915003836 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915003837 authentic frameshift 491915003838 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 491915003839 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 491915003840 active site 491915003841 dimer interface [polypeptide binding]; other site 491915003842 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 491915003843 Ligand Binding Site [chemical binding]; other site 491915003844 Molecular Tunnel; other site 491915003845 PrcB C-terminal; Region: PrcB_C; pfam14343 491915003846 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 491915003847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915003848 DNA photolyase; Region: DNA_photolyase; pfam00875 491915003849 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 491915003850 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915003851 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 491915003852 NAD(P) binding site [chemical binding]; other site 491915003853 catalytic residues [active] 491915003854 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 491915003855 Predicted membrane protein [Function unknown]; Region: COG2246 491915003856 GtrA-like protein; Region: GtrA; pfam04138 491915003857 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915003858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915003859 dimer interface [polypeptide binding]; other site 491915003860 putative CheW interface [polypeptide binding]; other site 491915003861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 491915003862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 491915003863 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 491915003864 putative dimerization interface [polypeptide binding]; other site 491915003865 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 491915003866 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 491915003867 active site 491915003868 dimer interface [polypeptide binding]; other site 491915003869 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 491915003870 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 491915003871 active site 491915003872 FMN binding site [chemical binding]; other site 491915003873 substrate binding site [chemical binding]; other site 491915003874 3Fe-4S cluster binding site [ion binding]; other site 491915003875 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 491915003876 domain interface; other site 491915003877 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 491915003878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915003879 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 491915003880 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 491915003881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915003882 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 491915003883 active site 491915003884 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 491915003885 CoA-transferase family III; Region: CoA_transf_3; pfam02515 491915003886 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 491915003887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915003888 inhibitor-cofactor binding pocket; inhibition site 491915003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915003890 catalytic residue [active] 491915003891 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 491915003892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915003893 NAD(P) binding site [chemical binding]; other site 491915003894 catalytic residues [active] 491915003895 amino acid transporter; Region: 2A0306; TIGR00909 491915003896 thiamine pyrophosphate protein; Validated; Region: PRK08199 491915003897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 491915003898 PYR/PP interface [polypeptide binding]; other site 491915003899 dimer interface [polypeptide binding]; other site 491915003900 TPP binding site [chemical binding]; other site 491915003901 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 491915003902 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 491915003903 TPP-binding site [chemical binding]; other site 491915003904 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 491915003905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915003906 NAD binding site [chemical binding]; other site 491915003907 catalytic residues [active] 491915003908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 491915003909 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 491915003910 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 491915003911 Ligand binding site [chemical binding]; other site 491915003912 Electron transfer flavoprotein domain; Region: ETF; pfam01012 491915003913 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 491915003914 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 491915003915 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 491915003916 oxidoreductase; Provisional; Region: PRK10015 491915003917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915003918 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 491915003919 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 491915003920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915003921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915003922 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 491915003923 PGAP1-like protein; Region: PGAP1; pfam07819 491915003924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 491915003925 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 491915003926 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 491915003927 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 491915003928 H+ Antiporter protein; Region: 2A0121; TIGR00900 491915003929 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915003930 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 491915003931 5'-3' exonuclease; Region: 53EXOc; smart00475 491915003932 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 491915003933 active site 491915003934 metal binding site 1 [ion binding]; metal-binding site 491915003935 putative 5' ssDNA interaction site; other site 491915003936 metal binding site 3; metal-binding site 491915003937 metal binding site 2 [ion binding]; metal-binding site 491915003938 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 491915003939 putative DNA binding site [nucleotide binding]; other site 491915003940 putative metal binding site [ion binding]; other site 491915003941 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 491915003942 classical (c) SDRs; Region: SDR_c; cd05233 491915003943 NAD(P) binding site [chemical binding]; other site 491915003944 active site 491915003945 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 491915003946 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 491915003947 siderophore binding site; other site 491915003948 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 491915003949 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915003950 ABC-ATPase subunit interface; other site 491915003951 dimer interface [polypeptide binding]; other site 491915003952 putative PBP binding regions; other site 491915003953 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 491915003954 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915003955 ABC-ATPase subunit interface; other site 491915003956 dimer interface [polypeptide binding]; other site 491915003957 putative PBP binding regions; other site 491915003958 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 491915003959 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 491915003960 Walker A/P-loop; other site 491915003961 ATP binding site [chemical binding]; other site 491915003962 Q-loop/lid; other site 491915003963 ABC transporter signature motif; other site 491915003964 Walker B; other site 491915003965 D-loop; other site 491915003966 H-loop/switch region; other site 491915003967 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 491915003968 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 491915003969 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 491915003970 putative catalytic cysteine [active] 491915003971 gamma-glutamyl kinase; Provisional; Region: PRK05429 491915003972 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 491915003973 nucleotide binding site [chemical binding]; other site 491915003974 homotetrameric interface [polypeptide binding]; other site 491915003975 putative phosphate binding site [ion binding]; other site 491915003976 putative allosteric binding site; other site 491915003977 PUA domain; Region: PUA; pfam01472 491915003978 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 491915003979 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 491915003980 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 491915003981 Walker A/P-loop; other site 491915003982 ATP binding site [chemical binding]; other site 491915003983 Q-loop/lid; other site 491915003984 ABC transporter signature motif; other site 491915003985 Walker B; other site 491915003986 D-loop; other site 491915003987 H-loop/switch region; other site 491915003988 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 491915003989 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 491915003990 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 491915003991 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 491915003992 Protein of unknown function (DUF342); Region: DUF342; pfam03961 491915003993 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 491915003994 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 491915003995 acyl-activating enzyme (AAE) consensus motif; other site 491915003996 putative AMP binding site [chemical binding]; other site 491915003997 putative active site [active] 491915003998 putative CoA binding site [chemical binding]; other site 491915003999 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 491915004000 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 491915004001 DNA binding residues [nucleotide binding] 491915004002 putative dimer interface [polypeptide binding]; other site 491915004003 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 491915004004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 491915004005 acyl-activating enzyme (AAE) consensus motif; other site 491915004006 AMP binding site [chemical binding]; other site 491915004007 active site 491915004008 CoA binding site [chemical binding]; other site 491915004009 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 491915004010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915004011 active site 491915004012 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 491915004013 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 491915004014 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 491915004015 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 491915004016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 491915004017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 491915004018 Protein of unknown function (DUF523); Region: DUF523; pfam04463 491915004019 Uncharacterized conserved protein [Function unknown]; Region: COG3272 491915004020 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 491915004021 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 491915004022 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 491915004023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 491915004024 intersubunit interface [polypeptide binding]; other site 491915004025 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 491915004026 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 491915004027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915004028 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 491915004029 dimer interface [polypeptide binding]; other site 491915004030 putative PBP binding regions; other site 491915004031 ABC-ATPase subunit interface; other site 491915004032 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 491915004033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915004034 ABC-ATPase subunit interface; other site 491915004035 dimer interface [polypeptide binding]; other site 491915004036 putative PBP binding regions; other site 491915004037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915004038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915004039 putative substrate translocation pore; other site 491915004040 Predicted membrane protein [Function unknown]; Region: COG4640 491915004041 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 491915004042 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 491915004043 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 491915004044 active site residue [active] 491915004045 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 491915004046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915004047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915004048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 491915004049 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 491915004050 active site residue [active] 491915004051 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915004052 active site residue [active] 491915004053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915004054 H+ Antiporter protein; Region: 2A0121; TIGR00900 491915004055 putative substrate translocation pore; other site 491915004056 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 491915004057 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 491915004058 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915004059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915004060 dimerization interface [polypeptide binding]; other site 491915004061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915004062 dimer interface [polypeptide binding]; other site 491915004063 putative CheW interface [polypeptide binding]; other site 491915004064 Transposase domain (DUF772); Region: DUF772; pfam05598 491915004065 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915004066 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915004067 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 491915004068 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 491915004069 ligand binding site [chemical binding]; other site 491915004070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 491915004071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915004072 dimerization interface [polypeptide binding]; other site 491915004073 Histidine kinase; Region: His_kinase; pfam06580 491915004074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004075 ATP binding site [chemical binding]; other site 491915004076 Mg2+ binding site [ion binding]; other site 491915004077 G-X-G motif; other site 491915004078 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 491915004079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915004080 active site 491915004081 phosphorylation site [posttranslational modification] 491915004082 intermolecular recognition site; other site 491915004083 dimerization interface [polypeptide binding]; other site 491915004084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 491915004085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 491915004086 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 491915004087 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 491915004088 putative ligand binding site [chemical binding]; other site 491915004089 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 491915004090 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 491915004091 Walker A/P-loop; other site 491915004092 ATP binding site [chemical binding]; other site 491915004093 Q-loop/lid; other site 491915004094 ABC transporter signature motif; other site 491915004095 Walker B; other site 491915004096 D-loop; other site 491915004097 H-loop/switch region; other site 491915004098 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 491915004099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915004100 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 491915004101 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 491915004102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915004103 TM-ABC transporter signature motif; other site 491915004104 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 491915004105 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 491915004106 active site 491915004107 octamer interface [polypeptide binding]; other site 491915004108 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 491915004109 DnaA N-terminal domain; Region: DnaA_N; pfam11638 491915004110 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 491915004111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915004112 Coenzyme A binding pocket [chemical binding]; other site 491915004113 Predicted amidohydrolase [General function prediction only]; Region: COG0388 491915004114 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 491915004115 putative active site [active] 491915004116 catalytic triad [active] 491915004117 putative dimer interface [polypeptide binding]; other site 491915004118 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 491915004119 catalytic residues [active] 491915004120 dimer interface [polypeptide binding]; other site 491915004121 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 491915004122 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 491915004123 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 491915004124 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 491915004125 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 491915004126 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 491915004127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 491915004128 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 491915004129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915004130 Walker A/P-loop; other site 491915004131 ATP binding site [chemical binding]; other site 491915004132 Q-loop/lid; other site 491915004133 ABC transporter signature motif; other site 491915004134 Walker B; other site 491915004135 D-loop; other site 491915004136 H-loop/switch region; other site 491915004137 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 491915004138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 491915004139 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 491915004140 Walker A/P-loop; other site 491915004141 ATP binding site [chemical binding]; other site 491915004142 Q-loop/lid; other site 491915004143 ABC transporter signature motif; other site 491915004144 Walker B; other site 491915004145 D-loop; other site 491915004146 H-loop/switch region; other site 491915004147 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 491915004148 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 491915004149 Endonuclease I; Region: Endonuclease_1; pfam04231 491915004150 authentic frameshift 491915004151 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 491915004152 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 491915004153 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 491915004154 metal binding triad; other site 491915004155 hypothetical protein; Provisional; Region: PRK07740 491915004156 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 491915004157 active site 491915004158 catalytic site [active] 491915004159 substrate binding site [chemical binding]; other site 491915004160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915004161 dimerization interface [polypeptide binding]; other site 491915004162 putative DNA binding site [nucleotide binding]; other site 491915004163 putative Zn2+ binding site [ion binding]; other site 491915004164 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 491915004165 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 491915004166 metal-binding site [ion binding] 491915004167 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 491915004168 Soluble P-type ATPase [General function prediction only]; Region: COG4087 491915004169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915004170 PAS fold; Region: PAS; pfam00989 491915004171 putative active site [active] 491915004172 heme pocket [chemical binding]; other site 491915004173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915004174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915004175 metal binding site [ion binding]; metal-binding site 491915004176 active site 491915004177 I-site; other site 491915004178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915004179 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 491915004180 NosL; Region: NosL; cl01769 491915004181 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 491915004182 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 491915004183 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 491915004184 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915004185 Walker A/P-loop; other site 491915004186 ATP binding site [chemical binding]; other site 491915004187 Q-loop/lid; other site 491915004188 ABC transporter signature motif; other site 491915004189 Walker B; other site 491915004190 D-loop; other site 491915004191 H-loop/switch region; other site 491915004192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 491915004193 catalytic core [active] 491915004194 Staphylococcal nuclease homologues; Region: SNc; smart00318 491915004195 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 491915004196 Catalytic site; other site 491915004197 hydroxylamine reductase; Provisional; Region: PRK12310 491915004198 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 491915004199 ACS interaction site; other site 491915004200 CODH interaction site; other site 491915004201 metal cluster binding site [ion binding]; other site 491915004202 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 491915004203 substrate binding site [chemical binding]; other site 491915004204 multimerization interface [polypeptide binding]; other site 491915004205 ATP binding site [chemical binding]; other site 491915004206 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 491915004207 thiamine phosphate binding site [chemical binding]; other site 491915004208 active site 491915004209 pyrophosphate binding site [ion binding]; other site 491915004210 enoyl-CoA hydratase; Provisional; Region: PRK07659 491915004211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 491915004212 substrate binding site [chemical binding]; other site 491915004213 oxyanion hole (OAH) forming residues; other site 491915004214 trimer interface [polypeptide binding]; other site 491915004215 Response regulator receiver domain; Region: Response_reg; pfam00072 491915004216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915004217 active site 491915004218 phosphorylation site [posttranslational modification] 491915004219 intermolecular recognition site; other site 491915004220 dimerization interface [polypeptide binding]; other site 491915004221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 491915004222 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 491915004223 anti sigma factor interaction site; other site 491915004224 regulatory phosphorylation site [posttranslational modification]; other site 491915004225 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 491915004226 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 491915004227 ATP binding site [chemical binding]; other site 491915004228 Mg2+ binding site [ion binding]; other site 491915004229 G-X-G motif; other site 491915004230 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 491915004231 heme-binding site [chemical binding]; other site 491915004232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915004233 dimer interface [polypeptide binding]; other site 491915004234 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 491915004235 putative CheW interface [polypeptide binding]; other site 491915004236 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 491915004237 cell division protein GpsB; Provisional; Region: PRK14127 491915004238 DivIVA domain; Region: DivI1A_domain; TIGR03544 491915004239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915004240 PAS domain; Region: PAS_9; pfam13426 491915004241 putative active site [active] 491915004242 heme pocket [chemical binding]; other site 491915004243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915004244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915004245 metal binding site [ion binding]; metal-binding site 491915004246 active site 491915004247 I-site; other site 491915004248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915004249 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 491915004250 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 491915004251 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 491915004252 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 491915004253 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 491915004254 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 491915004255 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 491915004256 active site 491915004257 Zn binding site [ion binding]; other site 491915004258 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 491915004259 Putative D-pathway homolog; other site 491915004260 Low-spin heme binding site [chemical binding]; other site 491915004261 Subunit I/II interface [polypeptide binding]; other site 491915004262 Putative Q-pathway; other site 491915004263 Putative alternate electron transfer pathway; other site 491915004264 Putative water exit pathway; other site 491915004265 Binuclear center (active site) [active] 491915004266 Putative K-pathway homolog; other site 491915004267 Putative proton exit pathway; other site 491915004268 Subunit I/IIa interface [polypeptide binding]; other site 491915004269 Electron transfer pathway; other site 491915004270 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 491915004271 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 491915004272 Transposase; Region: DEDD_Tnp_IS110; pfam01548 491915004273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 491915004274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 491915004275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 491915004276 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 491915004277 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 491915004278 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 491915004279 malonyl-CoA binding site [chemical binding]; other site 491915004280 dimer interface [polypeptide binding]; other site 491915004281 active site 491915004282 product binding site; other site 491915004283 Phospholipid methyltransferase; Region: PEMT; cl17370 491915004284 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 491915004285 Dynamin family; Region: Dynamin_N; pfam00350 491915004286 G1 box; other site 491915004287 GTP/Mg2+ binding site [chemical binding]; other site 491915004288 G2 box; other site 491915004289 Switch I region; other site 491915004290 G3 box; other site 491915004291 Switch II region; other site 491915004292 G4 box; other site 491915004293 G5 box; other site 491915004294 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 491915004295 Dynamin family; Region: Dynamin_N; pfam00350 491915004296 G1 box; other site 491915004297 GTP/Mg2+ binding site [chemical binding]; other site 491915004298 G2 box; other site 491915004299 Switch I region; other site 491915004300 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 491915004301 G3 box; other site 491915004302 Switch II region; other site 491915004303 GTP/Mg2+ binding site [chemical binding]; other site 491915004304 G4 box; other site 491915004305 G5 box; other site 491915004306 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 491915004307 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 491915004308 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915004309 catalytic residues [active] 491915004310 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 491915004311 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 491915004312 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 491915004313 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 491915004314 active site 491915004315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 491915004316 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 491915004317 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 491915004318 Cl binding site [ion binding]; other site 491915004319 oligomer interface [polypeptide binding]; other site 491915004320 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 491915004321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915004322 biotin synthase; Validated; Region: PRK06256 491915004323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915004324 FeS/SAM binding site; other site 491915004325 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 491915004326 YozD-like protein; Region: YozD; pfam14162 491915004327 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 491915004328 SpoOM protein; Region: Spo0M; pfam07070 491915004329 YodL-like; Region: YodL; pfam14191 491915004330 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 491915004331 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 491915004332 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 491915004333 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 491915004334 Predicted permease [General function prediction only]; Region: COG2056 491915004335 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 491915004336 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 491915004337 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 491915004338 Predicted permeases [General function prediction only]; Region: RarD; COG2962 491915004339 EamA-like transporter family; Region: EamA; pfam00892 491915004340 multidrug efflux protein; Reviewed; Region: PRK01766 491915004341 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 491915004342 cation binding site [ion binding]; other site 491915004343 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 491915004344 amino acid carrier protein; Region: agcS; TIGR00835 491915004345 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 491915004346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915004347 putative active site [active] 491915004348 heme pocket [chemical binding]; other site 491915004349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915004350 phosphorylation site [posttranslational modification] 491915004351 dimer interface [polypeptide binding]; other site 491915004352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004353 ATP binding site [chemical binding]; other site 491915004354 Mg2+ binding site [ion binding]; other site 491915004355 G-X-G motif; other site 491915004356 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 491915004357 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 491915004358 dimanganese center [ion binding]; other site 491915004359 threonine dehydratase; Provisional; Region: PRK08198 491915004360 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 491915004361 tetramer interface [polypeptide binding]; other site 491915004362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915004363 catalytic residue [active] 491915004364 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 491915004365 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 491915004366 NosL; Region: NosL; cl01769 491915004367 Predicted transcriptional regulators [Transcription]; Region: COG1725 491915004368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915004369 DNA-binding site [nucleotide binding]; DNA binding site 491915004370 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 491915004371 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915004372 Walker A/P-loop; other site 491915004373 ATP binding site [chemical binding]; other site 491915004374 Q-loop/lid; other site 491915004375 ABC transporter signature motif; other site 491915004376 Walker B; other site 491915004377 D-loop; other site 491915004378 H-loop/switch region; other site 491915004379 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 491915004380 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 491915004381 Peptidase family U32; Region: Peptidase_U32; pfam01136 491915004382 Collagenase; Region: DUF3656; pfam12392 491915004383 Peptidase family U32; Region: Peptidase_U32; pfam01136 491915004384 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 491915004385 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915004386 putative catalytic residue [active] 491915004387 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 491915004388 DNA-binding site [nucleotide binding]; DNA binding site 491915004389 RNA-binding motif; other site 491915004390 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 491915004391 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 491915004392 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 491915004393 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 491915004394 active site 491915004395 catalytic triad [active] 491915004396 oxyanion hole [active] 491915004397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 491915004398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915004399 Walker A/P-loop; other site 491915004400 ATP binding site [chemical binding]; other site 491915004401 Q-loop/lid; other site 491915004402 ABC transporter signature motif; other site 491915004403 Walker B; other site 491915004404 D-loop; other site 491915004405 H-loop/switch region; other site 491915004406 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 491915004407 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 491915004408 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 491915004409 putative active site [active] 491915004410 putative CoA binding site [chemical binding]; other site 491915004411 nudix motif; other site 491915004412 metal binding site [ion binding]; metal-binding site 491915004413 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 491915004414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915004415 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 491915004416 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 491915004417 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 491915004418 active site 491915004419 RNA/DNA hybrid binding site [nucleotide binding]; other site 491915004420 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 491915004421 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 491915004422 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 491915004423 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 491915004424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915004425 dimerization interface [polypeptide binding]; other site 491915004426 putative DNA binding site [nucleotide binding]; other site 491915004427 putative Zn2+ binding site [ion binding]; other site 491915004428 arsenical pump membrane protein; Provisional; Region: PRK15445 491915004429 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 491915004430 transmembrane helices; other site 491915004431 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 491915004432 Low molecular weight phosphatase family; Region: LMWPc; cd00115 491915004433 active site 491915004434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 491915004435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 491915004436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 491915004437 dimerization interface [polypeptide binding]; other site 491915004438 EamA-like transporter family; Region: EamA; pfam00892 491915004439 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 491915004440 EamA-like transporter family; Region: EamA; pfam00892 491915004441 EamA-like transporter family; Region: EamA; pfam00892 491915004442 EamA-like transporter family; Region: EamA; pfam00892 491915004443 short chain dehydrogenase; Provisional; Region: PRK06914 491915004444 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 491915004445 NADP binding site [chemical binding]; other site 491915004446 active site 491915004447 steroid binding site; other site 491915004448 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 491915004449 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915004450 Walker A/P-loop; other site 491915004451 ATP binding site [chemical binding]; other site 491915004452 Q-loop/lid; other site 491915004453 ABC transporter signature motif; other site 491915004454 Walker B; other site 491915004455 D-loop; other site 491915004456 H-loop/switch region; other site 491915004457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915004458 Coenzyme A binding pocket [chemical binding]; other site 491915004459 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 491915004460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 491915004461 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 491915004462 dimer interface [polypeptide binding]; other site 491915004463 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 491915004464 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 491915004465 DNA binding residues [nucleotide binding] 491915004466 dimer interface [polypeptide binding]; other site 491915004467 mercury binding site [ion binding]; other site 491915004468 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 491915004469 metal-binding site [ion binding] 491915004470 mercuric reductase; Region: MerA; TIGR02053 491915004471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915004472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915004473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 491915004474 DNA topoisomerase III C-terminus, disrupted by transposon 491915004475 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915004476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915004477 Winged helix-turn helix; Region: HTH_29; pfam13551 491915004478 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915004479 Homeodomain-like domain; Region: HTH_32; pfam13565 491915004480 Winged helix-turn helix; Region: HTH_33; pfam13592 491915004481 DNA topoisomerase III N-terminus, disrupted by transposon 491915004482 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 491915004483 amino acid carrier protein; Region: agcS; TIGR00835 491915004484 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 491915004485 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 491915004486 metal ion-dependent adhesion site (MIDAS); other site 491915004487 MoxR-like ATPases [General function prediction only]; Region: COG0714 491915004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915004489 Walker A motif; other site 491915004490 ATP binding site [chemical binding]; other site 491915004491 Walker B motif; other site 491915004492 arginine finger; other site 491915004493 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 491915004494 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 491915004495 putative homodimer interface [polypeptide binding]; other site 491915004496 putative homotetramer interface [polypeptide binding]; other site 491915004497 putative metal binding site [ion binding]; other site 491915004498 putative homodimer-homodimer interface [polypeptide binding]; other site 491915004499 putative allosteric switch controlling residues; other site 491915004500 Replication terminator protein; Region: RTP; pfam02334 491915004501 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 491915004502 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 491915004503 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 491915004504 putative active site [active] 491915004505 putative substrate binding site [chemical binding]; other site 491915004506 putative cosubstrate binding site; other site 491915004507 catalytic site [active] 491915004508 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 491915004509 spermidine synthase; Provisional; Region: PRK00811 491915004510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915004511 S-adenosylmethionine binding site [chemical binding]; other site 491915004512 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 491915004513 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 491915004514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915004515 DNA-binding site [nucleotide binding]; DNA binding site 491915004516 UTRA domain; Region: UTRA; pfam07702 491915004517 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 491915004518 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 491915004519 Ca binding site [ion binding]; other site 491915004520 active site 491915004521 catalytic site [active] 491915004522 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 491915004523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 491915004524 active site turn [active] 491915004525 phosphorylation site [posttranslational modification] 491915004526 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 491915004527 PilZ domain; Region: PilZ; pfam07238 491915004528 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 491915004529 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 491915004530 CAP-like domain; other site 491915004531 active site 491915004532 primary dimer interface [polypeptide binding]; other site 491915004533 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915004534 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915004535 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915004536 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 491915004537 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 491915004538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004539 ATP binding site [chemical binding]; other site 491915004540 Mg2+ binding site [ion binding]; other site 491915004541 G-X-G motif; other site 491915004542 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 491915004543 anchoring element; other site 491915004544 dimer interface [polypeptide binding]; other site 491915004545 ATP binding site [chemical binding]; other site 491915004546 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 491915004547 active site 491915004548 putative metal-binding site [ion binding]; other site 491915004549 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 491915004550 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 491915004551 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 491915004552 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 491915004553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915004554 S-adenosylmethionine binding site [chemical binding]; other site 491915004555 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 491915004556 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 491915004557 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 491915004558 active site 491915004559 catalytic triad [active] 491915004560 oxyanion hole [active] 491915004561 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 491915004562 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 491915004563 Cu(I) binding site [ion binding]; other site 491915004564 EDD domain protein, DegV family; Region: DegV; TIGR00762 491915004565 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 491915004566 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 491915004567 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 491915004568 threonine dehydratase; Validated; Region: PRK08639 491915004569 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 491915004570 tetramer interface [polypeptide binding]; other site 491915004571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915004572 catalytic residue [active] 491915004573 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 491915004574 putative Ile/Val binding site [chemical binding]; other site 491915004575 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 491915004576 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 491915004577 folate binding site [chemical binding]; other site 491915004578 NADP+ binding site [chemical binding]; other site 491915004579 thymidylate synthase; Reviewed; Region: thyA; PRK01827 491915004580 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 491915004581 dimerization interface [polypeptide binding]; other site 491915004582 active site 491915004583 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 491915004584 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 491915004585 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 491915004586 GIY-YIG motif/motif A; other site 491915004587 putative active site [active] 491915004588 putative metal binding site [ion binding]; other site 491915004589 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 491915004590 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 491915004591 YuzL-like protein; Region: YuzL; pfam14115 491915004592 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 491915004593 Disulphide isomerase; Region: Disulph_isomer; pfam06491 491915004594 homoserine O-succinyltransferase; Provisional; Region: PRK05368 491915004595 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 491915004596 proposed active site lysine [active] 491915004597 conserved cys residue [active] 491915004598 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 491915004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915004600 putative substrate translocation pore; other site 491915004601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915004602 Predicted transcriptional regulators [Transcription]; Region: COG1695 491915004603 Transcriptional regulator PadR-like family; Region: PadR; cl17335 491915004604 Methyltransferase domain; Region: Methyltransf_23; pfam13489 491915004605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915004606 S-adenosylmethionine binding site [chemical binding]; other site 491915004607 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 491915004608 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 491915004609 Acyltransferase family; Region: Acyl_transf_3; pfam01757 491915004610 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 491915004611 CHASE3 domain; Region: CHASE3; cl05000 491915004612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915004613 dimerization interface [polypeptide binding]; other site 491915004614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915004615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915004616 dimer interface [polypeptide binding]; other site 491915004617 putative CheW interface [polypeptide binding]; other site 491915004618 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 491915004619 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 491915004620 active site 491915004621 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 491915004622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915004623 dimer interface [polypeptide binding]; other site 491915004624 phosphorylation site [posttranslational modification] 491915004625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004626 ATP binding site [chemical binding]; other site 491915004627 Mg2+ binding site [ion binding]; other site 491915004628 G-X-G motif; other site 491915004629 flavodoxin; Provisional; Region: PRK06756 491915004630 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 491915004631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 491915004632 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 491915004633 active site 491915004634 phosphorylation site [posttranslational modification] 491915004635 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 491915004636 active site 491915004637 P-loop; other site 491915004638 phosphorylation site [posttranslational modification] 491915004639 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 491915004640 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 491915004641 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 491915004642 putative substrate binding site [chemical binding]; other site 491915004643 putative ATP binding site [chemical binding]; other site 491915004644 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 491915004645 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 491915004646 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 491915004647 Low affinity iron permease; Region: Iron_permease; cl12096 491915004648 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915004649 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915004650 metal binding site [ion binding]; metal-binding site 491915004651 active site 491915004652 I-site; other site 491915004653 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 491915004654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915004655 Zn2+ binding site [ion binding]; other site 491915004656 Mg2+ binding site [ion binding]; other site 491915004657 glycerol kinase; Provisional; Region: glpK; PRK00047 491915004658 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 491915004659 N- and C-terminal domain interface [polypeptide binding]; other site 491915004660 active site 491915004661 MgATP binding site [chemical binding]; other site 491915004662 catalytic site [active] 491915004663 metal binding site [ion binding]; metal-binding site 491915004664 glycerol binding site [chemical binding]; other site 491915004665 homotetramer interface [polypeptide binding]; other site 491915004666 homodimer interface [polypeptide binding]; other site 491915004667 FBP binding site [chemical binding]; other site 491915004668 protein IIAGlc interface [polypeptide binding]; other site 491915004669 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 491915004670 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 491915004671 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 491915004672 DNA-binding site [nucleotide binding]; DNA binding site 491915004673 RNA-binding motif; other site 491915004674 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 491915004675 hypothetical protein; Validated; Region: PRK07708 491915004676 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 491915004677 RNA/DNA hybrid binding site [nucleotide binding]; other site 491915004678 active site 491915004679 conserved hypothetical integral membrane protein; Region: TIGR00697 491915004680 EamA-like transporter family; Region: EamA; pfam00892 491915004681 Divergent PAP2 family; Region: DUF212; pfam02681 491915004682 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 491915004683 aconitate hydratase; Validated; Region: PRK09277 491915004684 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 491915004685 substrate binding site [chemical binding]; other site 491915004686 ligand binding site [chemical binding]; other site 491915004687 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 491915004688 substrate binding site [chemical binding]; other site 491915004689 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 491915004690 Transposase domain (DUF772); Region: DUF772; pfam05598 491915004691 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915004692 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915004693 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 491915004694 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 491915004695 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 491915004696 Response regulator receiver domain; Region: Response_reg; pfam00072 491915004697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915004698 active site 491915004699 phosphorylation site [posttranslational modification] 491915004700 intermolecular recognition site; other site 491915004701 dimerization interface [polypeptide binding]; other site 491915004702 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 491915004703 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 491915004704 hypothetical protein; Provisional; Region: PRK01844 491915004705 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 491915004706 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 491915004707 TPP-binding site [chemical binding]; other site 491915004708 dimer interface [polypeptide binding]; other site 491915004709 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 491915004710 PYR/PP interface [polypeptide binding]; other site 491915004711 dimer interface [polypeptide binding]; other site 491915004712 TPP binding site [chemical binding]; other site 491915004713 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 491915004714 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 491915004715 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 491915004716 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 491915004717 catalytic residues [active] 491915004718 catalytic nucleophile [active] 491915004719 cell division suppressor protein YneA; Provisional; Region: PRK14125 491915004720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915004721 LexA repressor; Validated; Region: PRK00215 491915004722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915004723 putative DNA binding site [nucleotide binding]; other site 491915004724 putative Zn2+ binding site [ion binding]; other site 491915004725 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 491915004726 Catalytic site [active] 491915004727 glutamine synthetase, type I; Region: GlnA; TIGR00653 491915004728 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 491915004729 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 491915004730 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 491915004731 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 491915004732 DNA binding residues [nucleotide binding] 491915004733 putative dimer interface [polypeptide binding]; other site 491915004734 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 491915004735 Aluminium resistance protein; Region: Alum_res; pfam06838 491915004736 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 491915004737 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 491915004738 HflX GTPase family; Region: HflX; cd01878 491915004739 G1 box; other site 491915004740 GTP/Mg2+ binding site [chemical binding]; other site 491915004741 Switch I region; other site 491915004742 G2 box; other site 491915004743 G3 box; other site 491915004744 Switch II region; other site 491915004745 G4 box; other site 491915004746 G5 box; other site 491915004747 Predicted membrane protein [Function unknown]; Region: COG2860 491915004748 UPF0126 domain; Region: UPF0126; pfam03458 491915004749 UPF0126 domain; Region: UPF0126; pfam03458 491915004750 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 491915004751 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 491915004752 dimer interface [polypeptide binding]; other site 491915004753 active site 491915004754 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 491915004755 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 491915004756 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 491915004757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915004758 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 491915004759 active site 491915004760 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 491915004761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 491915004762 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 491915004763 acyl-activating enzyme (AAE) consensus motif; other site 491915004764 putative AMP binding site [chemical binding]; other site 491915004765 putative active site [active] 491915004766 putative CoA binding site [chemical binding]; other site 491915004767 stage V sporulation protein K; Region: spore_V_K; TIGR02881 491915004768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915004769 Walker A motif; other site 491915004770 ATP binding site [chemical binding]; other site 491915004771 Walker B motif; other site 491915004772 arginine finger; other site 491915004773 bacterial Hfq-like; Region: Hfq; cd01716 491915004774 hexamer interface [polypeptide binding]; other site 491915004775 Sm1 motif; other site 491915004776 RNA binding site [nucleotide binding]; other site 491915004777 Sm2 motif; other site 491915004778 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 491915004779 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 491915004780 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 491915004781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004782 ATP binding site [chemical binding]; other site 491915004783 Mg2+ binding site [ion binding]; other site 491915004784 G-X-G motif; other site 491915004785 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 491915004786 ATP binding site [chemical binding]; other site 491915004787 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 491915004788 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 491915004789 MutS domain I; Region: MutS_I; pfam01624 491915004790 MutS domain II; Region: MutS_II; pfam05188 491915004791 MutS domain III; Region: MutS_III; pfam05192 491915004792 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 491915004793 Walker A/P-loop; other site 491915004794 ATP binding site [chemical binding]; other site 491915004795 Q-loop/lid; other site 491915004796 ABC transporter signature motif; other site 491915004797 Walker B; other site 491915004798 D-loop; other site 491915004799 H-loop/switch region; other site 491915004800 Outer spore coat protein E (CotE); Region: CotE; pfam10628 491915004801 Predicted membrane protein [Function unknown]; Region: COG4550 491915004802 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 491915004803 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 491915004804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915004805 FeS/SAM binding site; other site 491915004806 TRAM domain; Region: TRAM; cl01282 491915004807 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 491915004808 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 491915004809 TPP-binding site [chemical binding]; other site 491915004810 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 491915004811 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 491915004812 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 491915004813 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 491915004814 PYR/PP interface [polypeptide binding]; other site 491915004815 TPP binding site [chemical binding]; other site 491915004816 dimer interface [polypeptide binding]; other site 491915004817 substrate binding site [chemical binding]; other site 491915004818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 491915004819 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 491915004820 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 491915004821 active site 491915004822 dimer interface [polypeptide binding]; other site 491915004823 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 491915004824 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 491915004825 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 491915004826 putative active site [active] 491915004827 metal binding site [ion binding]; metal-binding site 491915004828 homodimer binding site [polypeptide binding]; other site 491915004829 phosphodiesterase; Provisional; Region: PRK12704 491915004830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915004831 Zn2+ binding site [ion binding]; other site 491915004832 Mg2+ binding site [ion binding]; other site 491915004833 Cation efflux family; Region: Cation_efflux; cl00316 491915004834 recombinase A; Provisional; Region: recA; PRK09354 491915004835 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 491915004836 hexamer interface [polypeptide binding]; other site 491915004837 Walker A motif; other site 491915004838 ATP binding site [chemical binding]; other site 491915004839 Walker B motif; other site 491915004840 competence damage-inducible protein A; Provisional; Region: PRK00549 491915004841 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 491915004842 putative MPT binding site; other site 491915004843 Competence-damaged protein; Region: CinA; pfam02464 491915004844 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 491915004845 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 491915004846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915004847 non-specific DNA binding site [nucleotide binding]; other site 491915004848 salt bridge; other site 491915004849 sequence-specific DNA binding site [nucleotide binding]; other site 491915004850 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 491915004851 ACT domain; Region: ACT; pfam01842 491915004852 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 491915004853 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 491915004854 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 491915004855 classical (c) SDRs; Region: SDR_c; cd05233 491915004856 NAD(P) binding site [chemical binding]; other site 491915004857 active site 491915004858 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 491915004859 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 491915004860 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 491915004861 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 491915004862 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 491915004863 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 491915004864 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 491915004865 dimer interface [polypeptide binding]; other site 491915004866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915004867 catalytic residue [active] 491915004868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915004869 active site residue [active] 491915004870 DNA topoisomerase III; Provisional; Region: PRK07726 491915004871 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 491915004872 active site 491915004873 putative interdomain interaction site [polypeptide binding]; other site 491915004874 putative metal-binding site [ion binding]; other site 491915004875 putative nucleotide binding site [chemical binding]; other site 491915004876 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 491915004877 domain I; other site 491915004878 DNA binding groove [nucleotide binding] 491915004879 phosphate binding site [ion binding]; other site 491915004880 domain II; other site 491915004881 domain III; other site 491915004882 nucleotide binding site [chemical binding]; other site 491915004883 catalytic site [active] 491915004884 domain IV; other site 491915004885 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 491915004886 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 491915004887 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 491915004888 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 491915004889 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 491915004890 DNA binding residues [nucleotide binding] 491915004891 putative dimer interface [polypeptide binding]; other site 491915004892 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 491915004893 Domain of unknown function (DUF897); Region: DUF897; pfam05982 491915004894 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 491915004895 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 491915004896 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 491915004897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915004898 motif II; other site 491915004899 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 491915004900 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 491915004901 active site 491915004902 NAD binding site [chemical binding]; other site 491915004903 metal binding site [ion binding]; metal-binding site 491915004904 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 491915004905 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 491915004906 Probable transposase; Region: OrfB_IS605; pfam01385 491915004907 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915004908 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915004909 Imidazolonepropionase C-terminal fragment 491915004910 hypothetical protein; Provisional; Region: PRK02237 491915004911 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 491915004912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915004913 dimer interface [polypeptide binding]; other site 491915004914 phosphorylation site [posttranslational modification] 491915004915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915004916 ATP binding site [chemical binding]; other site 491915004917 Mg2+ binding site [ion binding]; other site 491915004918 G-X-G motif; other site 491915004919 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 491915004920 Predicted permeases [General function prediction only]; Region: COG0701 491915004921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915004922 dimerization interface [polypeptide binding]; other site 491915004923 putative DNA binding site [nucleotide binding]; other site 491915004924 putative Zn2+ binding site [ion binding]; other site 491915004925 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 491915004926 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 491915004927 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 491915004928 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 491915004929 active site 491915004930 phosphorylation site [posttranslational modification] 491915004931 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 491915004932 HTH domain; Region: HTH_11; pfam08279 491915004933 HTH domain; Region: HTH_11; cl17392 491915004934 PRD domain; Region: PRD; pfam00874 491915004935 PRD domain; Region: PRD; pfam00874 491915004936 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 491915004937 active site 491915004938 P-loop; other site 491915004939 phosphorylation site [posttranslational modification] 491915004940 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 491915004941 active site 491915004942 phosphorylation site [posttranslational modification] 491915004943 Transposase domain (DUF772); Region: DUF772; pfam05598 491915004944 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915004945 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915004946 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 491915004947 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 491915004948 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 491915004949 active site 491915004950 P-loop; other site 491915004951 phosphorylation site [posttranslational modification] 491915004952 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 491915004953 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 491915004954 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 491915004955 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 491915004956 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 491915004957 Transcriptional regulator [Transcription]; Region: IclR; COG1414 491915004958 Bacterial transcriptional regulator; Region: IclR; pfam01614 491915004959 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 491915004960 active site 491915004961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915004962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915004963 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 491915004964 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 491915004965 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 491915004966 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915004967 Walker A/P-loop; other site 491915004968 ATP binding site [chemical binding]; other site 491915004969 Q-loop/lid; other site 491915004970 ABC transporter signature motif; other site 491915004971 Walker B; other site 491915004972 D-loop; other site 491915004973 H-loop/switch region; other site 491915004974 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 491915004975 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 491915004976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 491915004977 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 491915004978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915004979 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 491915004980 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 491915004981 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 491915004982 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 491915004983 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 491915004984 MarR family; Region: MarR; pfam01047 491915004985 MarR family; Region: MarR_2; cl17246 491915004986 Pirin-related protein [General function prediction only]; Region: COG1741 491915004987 Pirin; Region: Pirin; pfam02678 491915004988 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 491915004989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915004990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915004991 putative substrate translocation pore; other site 491915004992 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 491915004993 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 491915004994 Potassium binding sites [ion binding]; other site 491915004995 Cesium cation binding sites [ion binding]; other site 491915004996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 491915004997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 491915004998 active site 491915004999 catalytic tetrad [active] 491915005000 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 491915005001 Predicted integral membrane protein [Function unknown]; Region: COG5658 491915005002 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 491915005003 SdpI/YhfL protein family; Region: SdpI; pfam13630 491915005004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915005005 dimerization interface [polypeptide binding]; other site 491915005006 putative DNA binding site [nucleotide binding]; other site 491915005007 putative Zn2+ binding site [ion binding]; other site 491915005008 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 491915005009 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 491915005010 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 491915005011 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 491915005012 active site 491915005013 catalytic site [active] 491915005014 metal binding site [ion binding]; metal-binding site 491915005015 dimer interface [polypeptide binding]; other site 491915005016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 491915005017 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 491915005018 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 491915005019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915005020 dimer interface [polypeptide binding]; other site 491915005021 conserved gate region; other site 491915005022 putative PBP binding loops; other site 491915005023 ABC-ATPase subunit interface; other site 491915005024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915005025 dimer interface [polypeptide binding]; other site 491915005026 conserved gate region; other site 491915005027 putative PBP binding loops; other site 491915005028 ABC-ATPase subunit interface; other site 491915005029 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 491915005030 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 491915005031 Walker A/P-loop; other site 491915005032 ATP binding site [chemical binding]; other site 491915005033 Q-loop/lid; other site 491915005034 ABC transporter signature motif; other site 491915005035 Walker B; other site 491915005036 D-loop; other site 491915005037 H-loop/switch region; other site 491915005038 TOBE domain; Region: TOBE_2; pfam08402 491915005039 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 491915005040 sulfite reductase subunit beta; Provisional; Region: PRK13504 491915005041 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 491915005042 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 491915005043 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 491915005044 Flavodoxin; Region: Flavodoxin_1; pfam00258 491915005045 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 491915005046 FAD binding pocket [chemical binding]; other site 491915005047 FAD binding motif [chemical binding]; other site 491915005048 catalytic residues [active] 491915005049 NAD binding pocket [chemical binding]; other site 491915005050 phosphate binding motif [ion binding]; other site 491915005051 beta-alpha-beta structure motif; other site 491915005052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 491915005053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 491915005054 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 491915005055 putative dimerization interface [polypeptide binding]; other site 491915005056 Small acid-soluble spore protein H family; Region: SspH; pfam08141 491915005057 NAD-dependent deacetylase; Provisional; Region: PRK00481 491915005058 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 491915005059 Predicted membrane protein [Function unknown]; Region: COG3428 491915005060 Bacterial PH domain; Region: DUF304; pfam03703 491915005061 Bacterial PH domain; Region: DUF304; pfam03703 491915005062 Bacterial PH domain; Region: DUF304; pfam03703 491915005063 Uncharacterized conserved protein [Function unknown]; Region: COG3402 491915005064 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 491915005065 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 491915005066 NAD(P) binding site [chemical binding]; other site 491915005067 catalytic residues [active] 491915005068 Protein of unknown function (DUF779); Region: DUF779; pfam05610 491915005069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915005070 Protein of unknown function (DUF817); Region: DUF817; pfam05675 491915005071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915005072 salt bridge; other site 491915005073 non-specific DNA binding site [nucleotide binding]; other site 491915005074 sequence-specific DNA binding site [nucleotide binding]; other site 491915005075 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 491915005076 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 491915005077 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 491915005078 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 491915005079 Uncharacterized conserved protein [Function unknown]; Region: COG5646 491915005080 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 491915005081 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 491915005082 P-loop; other site 491915005083 Magnesium ion binding site [ion binding]; other site 491915005084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 491915005085 Magnesium ion binding site [ion binding]; other site 491915005086 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 491915005087 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915005088 catalytic residues [active] 491915005089 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 491915005090 putative active site pocket [active] 491915005091 dimerization interface [polypeptide binding]; other site 491915005092 putative catalytic residue [active] 491915005093 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 491915005094 putative active site pocket [active] 491915005095 dimerization interface [polypeptide binding]; other site 491915005096 putative catalytic residue [active] 491915005097 Predicted acetyltransferase [General function prediction only]; Region: COG3393 491915005098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915005099 Coenzyme A binding pocket [chemical binding]; other site 491915005100 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 491915005101 putative active site [active] 491915005102 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 491915005103 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 491915005104 catalytic residues [active] 491915005105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 491915005106 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 491915005107 dimer interface [polypeptide binding]; other site 491915005108 putative metal binding site [ion binding]; other site 491915005109 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 491915005110 Virulence factor; Region: Virulence_fact; pfam13769 491915005111 HEAT repeats; Region: HEAT_2; pfam13646 491915005112 HEAT repeat; Region: HEAT; pfam02985 491915005113 HEAT repeats; Region: HEAT_2; pfam13646 491915005114 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 491915005115 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 491915005116 nudix motif; other site 491915005117 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 491915005118 nudix motif; other site 491915005119 This domain is found in the protein Piwi and its relatives; Region: Piwi; smart00950 491915005120 5' RNA guide strand anchoring site; other site 491915005121 active site 491915005122 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 491915005123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 491915005124 Transposase; Region: DEDD_Tnp_IS110; pfam01548 491915005125 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 491915005126 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 491915005127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915005128 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915005129 HTH-like domain; Region: HTH_21; pfam13276 491915005130 Integrase core domain; Region: rve; pfam00665 491915005131 Integrase core domain; Region: rve_3; pfam13683 491915005132 Protein of unknown function DUF262; Region: DUF262; pfam03235 491915005133 Uncharacterized conserved protein [Function unknown]; Region: COG1479 491915005134 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 491915005135 Competence protein CoiA-like family; Region: CoiA; cl11541 491915005136 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 491915005137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915005138 AAA domain; Region: AAA_21; pfam13304 491915005139 Walker A/P-loop; other site 491915005140 ATP binding site [chemical binding]; other site 491915005141 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 491915005142 putative active site [active] 491915005143 putative metal-binding site [ion binding]; other site 491915005144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915005145 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 491915005146 Walker A motif; other site 491915005147 ATP binding site [chemical binding]; other site 491915005148 Walker B motif; other site 491915005149 Uncharacterized conserved protein [Function unknown]; Region: COG3410 491915005150 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 491915005151 homodimer interface [polypeptide binding]; other site 491915005152 chemical substrate binding site [chemical binding]; other site 491915005153 oligomer interface [polypeptide binding]; other site 491915005154 metal binding site [ion binding]; metal-binding site 491915005155 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 491915005156 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 491915005157 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 491915005158 Helix-turn-helix domain; Region: HTH_38; pfam13936 491915005159 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915005160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915005161 Winged helix-turn helix; Region: HTH_29; pfam13551 491915005162 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915005163 Homeodomain-like domain; Region: HTH_32; pfam13565 491915005164 Winged helix-turn helix; Region: HTH_33; pfam13592 491915005165 authentic frameshift 491915005166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 491915005167 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 491915005168 ThiC-associated domain; Region: ThiC-associated; pfam13667 491915005169 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 491915005170 ThiC family; Region: ThiC; pfam01964 491915005171 malate:quinone oxidoreductase; Validated; Region: PRK05257 491915005172 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 491915005173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915005174 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915005175 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915005176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915005177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915005178 metal binding site [ion binding]; metal-binding site 491915005179 active site 491915005180 I-site; other site 491915005181 Protein of unknown function (DUF975); Region: DUF975; cl10504 491915005182 Transposase; Region: DEDD_Tnp_IS110; pfam01548 491915005183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 491915005184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 491915005185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 491915005186 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 491915005187 Double zinc ribbon; Region: DZR; pfam12773 491915005188 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 491915005189 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 491915005190 Sulfate transporter family; Region: Sulfate_transp; pfam00916 491915005191 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 491915005192 T-box leader; Aflv_R088 491915005193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 491915005194 Ligand Binding Site [chemical binding]; other site 491915005195 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 491915005196 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 491915005197 putative active site [active] 491915005198 putative metal binding site [ion binding]; other site 491915005199 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 491915005200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915005201 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 491915005202 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 491915005203 Transposase; Region: DDE_Tnp_ISL3; pfam01610 491915005204 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 491915005205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 491915005206 dimer interface [polypeptide binding]; other site 491915005207 putative metal binding site [ion binding]; other site 491915005208 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915005209 Homeodomain-like domain; Region: HTH_32; pfam13565 491915005210 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 491915005211 Integrase core domain; Region: rve; pfam00665 491915005212 Integrase core domain; Region: rve_3; pfam13683 491915005213 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 491915005214 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 491915005215 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 491915005216 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 491915005217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915005218 TM-ABC transporter signature motif; other site 491915005219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915005220 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 491915005221 TM-ABC transporter signature motif; other site 491915005222 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 491915005223 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 491915005224 Walker A/P-loop; other site 491915005225 ATP binding site [chemical binding]; other site 491915005226 Q-loop/lid; other site 491915005227 ABC transporter signature motif; other site 491915005228 Walker B; other site 491915005229 D-loop; other site 491915005230 H-loop/switch region; other site 491915005231 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 491915005232 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 491915005233 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 491915005234 ligand binding site [chemical binding]; other site 491915005235 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 491915005236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915005237 DNA-binding site [nucleotide binding]; DNA binding site 491915005238 UTRA domain; Region: UTRA; pfam07702 491915005239 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 491915005240 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 491915005241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 491915005242 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 491915005243 YlzJ-like protein; Region: YlzJ; pfam14035 491915005244 Clp protease; Region: CLP_protease; pfam00574 491915005245 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 491915005246 active site 491915005247 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 491915005248 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 491915005249 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 491915005250 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 491915005251 dihydrodipicolinate synthase; Region: dapA; TIGR00674 491915005252 dimer interface [polypeptide binding]; other site 491915005253 active site 491915005254 catalytic residue [active] 491915005255 aspartate kinase I; Reviewed; Region: PRK08210 491915005256 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 491915005257 nucleotide binding site [chemical binding]; other site 491915005258 substrate binding site [chemical binding]; other site 491915005259 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 491915005260 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 491915005261 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 491915005262 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 491915005263 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 491915005264 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 491915005265 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 491915005266 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 491915005267 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 491915005268 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 491915005269 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 491915005270 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 491915005271 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 491915005272 NodB motif; other site 491915005273 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 491915005274 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 491915005275 RNase E interface [polypeptide binding]; other site 491915005276 trimer interface [polypeptide binding]; other site 491915005277 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 491915005278 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 491915005279 RNase E interface [polypeptide binding]; other site 491915005280 trimer interface [polypeptide binding]; other site 491915005281 active site 491915005282 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 491915005283 putative nucleic acid binding region [nucleotide binding]; other site 491915005284 G-X-X-G motif; other site 491915005285 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 491915005286 RNA binding site [nucleotide binding]; other site 491915005287 domain interface; other site 491915005288 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 491915005289 16S/18S rRNA binding site [nucleotide binding]; other site 491915005290 S13e-L30e interaction site [polypeptide binding]; other site 491915005291 25S rRNA binding site [nucleotide binding]; other site 491915005292 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 491915005293 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 491915005294 active site 491915005295 Riboflavin kinase; Region: Flavokinase; pfam01687 491915005296 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 491915005297 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 491915005298 RNA binding site [nucleotide binding]; other site 491915005299 active site 491915005300 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 491915005301 Protein of unknown function (DUF503); Region: DUF503; cl00669 491915005302 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 491915005303 translation initiation factor IF-2; Region: IF-2; TIGR00487 491915005304 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 491915005305 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 491915005306 G1 box; other site 491915005307 putative GEF interaction site [polypeptide binding]; other site 491915005308 GTP/Mg2+ binding site [chemical binding]; other site 491915005309 Switch I region; other site 491915005310 G2 box; other site 491915005311 G3 box; other site 491915005312 Switch II region; other site 491915005313 G4 box; other site 491915005314 G5 box; other site 491915005315 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 491915005316 Translation-initiation factor 2; Region: IF-2; pfam11987 491915005317 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 491915005318 hypothetical protein; Provisional; Region: PRK07714 491915005319 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 491915005320 putative RNA binding cleft [nucleotide binding]; other site 491915005321 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 491915005322 NusA N-terminal domain; Region: NusA_N; pfam08529 491915005323 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 491915005324 RNA binding site [nucleotide binding]; other site 491915005325 homodimer interface [polypeptide binding]; other site 491915005326 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 491915005327 G-X-X-G motif; other site 491915005328 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 491915005329 G-X-X-G motif; other site 491915005330 ribosome maturation protein RimP; Reviewed; Region: PRK00092 491915005331 Sm and related proteins; Region: Sm_like; cl00259 491915005332 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 491915005333 putative oligomer interface [polypeptide binding]; other site 491915005334 putative RNA binding site [nucleotide binding]; other site 491915005335 DNA polymerase III PolC; Validated; Region: polC; PRK00448 491915005336 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 491915005337 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 491915005338 generic binding surface I; other site 491915005339 generic binding surface II; other site 491915005340 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 491915005341 active site 491915005342 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 491915005343 active site 491915005344 catalytic site [active] 491915005345 substrate binding site [chemical binding]; other site 491915005346 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 491915005347 prolyl-tRNA synthetase; Provisional; Region: PRK09194 491915005348 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 491915005349 dimer interface [polypeptide binding]; other site 491915005350 motif 1; other site 491915005351 active site 491915005352 motif 2; other site 491915005353 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 491915005354 putative deacylase active site [active] 491915005355 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 491915005356 active site 491915005357 motif 3; other site 491915005358 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 491915005359 anticodon binding site; other site 491915005360 RIP metalloprotease RseP; Region: TIGR00054 491915005361 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 491915005362 active site 491915005363 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 491915005364 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 491915005365 protein binding site [polypeptide binding]; other site 491915005366 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 491915005367 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 491915005368 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 491915005369 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 491915005370 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 491915005371 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 491915005372 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 491915005373 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 491915005374 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 491915005375 catalytic residue [active] 491915005376 putative FPP diphosphate binding site; other site 491915005377 putative FPP binding hydrophobic cleft; other site 491915005378 dimer interface [polypeptide binding]; other site 491915005379 putative IPP diphosphate binding site; other site 491915005380 ribosome recycling factor; Reviewed; Region: frr; PRK00083 491915005381 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 491915005382 hinge region; other site 491915005383 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 491915005384 putative nucleotide binding site [chemical binding]; other site 491915005385 uridine monophosphate binding site [chemical binding]; other site 491915005386 homohexameric interface [polypeptide binding]; other site 491915005387 elongation factor Ts; Provisional; Region: tsf; PRK09377 491915005388 UBA/TS-N domain; Region: UBA; pfam00627 491915005389 Elongation factor TS; Region: EF_TS; pfam00889 491915005390 Elongation factor TS; Region: EF_TS; pfam00889 491915005391 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 491915005392 rRNA interaction site [nucleotide binding]; other site 491915005393 S8 interaction site; other site 491915005394 putative laminin-1 binding site; other site 491915005395 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 491915005396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915005397 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 491915005398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915005399 DNA binding residues [nucleotide binding] 491915005400 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 491915005401 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 491915005402 CheC-like family; Region: CheC; pfam04509 491915005403 CheC-like family; Region: CheC; pfam04509 491915005404 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 491915005405 putative CheA interaction surface; other site 491915005406 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 491915005407 putative binding surface; other site 491915005408 active site 491915005409 P2 response regulator binding domain; Region: P2; pfam07194 491915005410 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 491915005411 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 491915005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915005413 ATP binding site [chemical binding]; other site 491915005414 Mg2+ binding site [ion binding]; other site 491915005415 G-X-G motif; other site 491915005416 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 491915005417 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 491915005418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915005419 active site 491915005420 phosphorylation site [posttranslational modification] 491915005421 intermolecular recognition site; other site 491915005422 dimerization interface [polypeptide binding]; other site 491915005423 CheB methylesterase; Region: CheB_methylest; pfam01339 491915005424 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 491915005425 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915005426 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 491915005427 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 491915005428 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915005429 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 491915005430 FHIPEP family; Region: FHIPEP; pfam00771 491915005431 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 491915005432 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 491915005433 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 491915005434 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 491915005435 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 491915005436 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 491915005437 Response regulator receiver domain; Region: Response_reg; pfam00072 491915005438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915005439 active site 491915005440 phosphorylation site [posttranslational modification] 491915005441 intermolecular recognition site; other site 491915005442 dimerization interface [polypeptide binding]; other site 491915005443 flagellar motor switch protein; Validated; Region: PRK08119 491915005444 CheC-like family; Region: CheC; pfam04509 491915005445 CheC-like family; Region: CheC; pfam04509 491915005446 flagellar motor switch protein FliN; Region: fliN; TIGR02480 491915005447 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 491915005448 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 491915005449 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 491915005450 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 491915005451 Flagellar protein (FlbD); Region: FlbD; pfam06289 491915005452 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 491915005453 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915005454 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 491915005455 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 491915005456 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 491915005457 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 491915005458 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 491915005459 Uncharacterized conserved protein [Function unknown]; Region: COG3334 491915005460 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 491915005461 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 491915005462 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 491915005463 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 491915005464 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 491915005465 Walker A motif/ATP binding site; other site 491915005466 Walker B motif; other site 491915005467 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 491915005468 Flagellar assembly protein FliH; Region: FliH; pfam02108 491915005469 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 491915005470 FliG C-terminal domain; Region: FliG_C; pfam01706 491915005471 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 491915005472 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 491915005473 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 491915005474 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 491915005475 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 491915005476 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915005477 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 491915005478 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 491915005479 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915005480 transcriptional repressor CodY; Validated; Region: PRK04158 491915005481 CodY GAF-like domain; Region: CodY; pfam06018 491915005482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915005483 putative DNA binding site [nucleotide binding]; other site 491915005484 putative Zn2+ binding site [ion binding]; other site 491915005485 dimerization interface [polypeptide binding]; other site 491915005486 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 491915005487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915005488 Walker A motif; other site 491915005489 ATP binding site [chemical binding]; other site 491915005490 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 491915005491 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 491915005492 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 491915005493 active site 491915005494 HslU subunit interaction site [polypeptide binding]; other site 491915005495 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 491915005496 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 491915005497 active site 491915005498 Int/Topo IB signature motif; other site 491915005499 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 491915005500 Glucose inhibited division protein A; Region: GIDA; pfam01134 491915005501 DNA topoisomerase I; Validated; Region: PRK05582 491915005502 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 491915005503 active site 491915005504 interdomain interaction site; other site 491915005505 putative metal-binding site [ion binding]; other site 491915005506 nucleotide binding site [chemical binding]; other site 491915005507 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 491915005508 domain I; other site 491915005509 DNA binding groove [nucleotide binding] 491915005510 phosphate binding site [ion binding]; other site 491915005511 domain II; other site 491915005512 domain III; other site 491915005513 nucleotide binding site [chemical binding]; other site 491915005514 catalytic site [active] 491915005515 domain IV; other site 491915005516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 491915005517 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 491915005518 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 491915005519 DNA protecting protein DprA; Region: dprA; TIGR00732 491915005520 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 491915005521 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 491915005522 CoA binding domain; Region: CoA_binding; pfam02629 491915005523 CoA-ligase; Region: Ligase_CoA; pfam00549 491915005524 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 491915005525 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 491915005526 CoA-ligase; Region: Ligase_CoA; pfam00549 491915005527 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 491915005528 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 491915005529 RNA/DNA hybrid binding site [nucleotide binding]; other site 491915005530 active site 491915005531 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 491915005532 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 491915005533 GTP/Mg2+ binding site [chemical binding]; other site 491915005534 G4 box; other site 491915005535 G5 box; other site 491915005536 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 491915005537 G1 box; other site 491915005538 G1 box; other site 491915005539 GTP/Mg2+ binding site [chemical binding]; other site 491915005540 Switch I region; other site 491915005541 G2 box; other site 491915005542 G2 box; other site 491915005543 Switch I region; other site 491915005544 G3 box; other site 491915005545 G3 box; other site 491915005546 Switch II region; other site 491915005547 Switch II region; other site 491915005548 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 491915005549 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 491915005550 Catalytic site [active] 491915005551 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 491915005552 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 491915005553 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 491915005554 RimM N-terminal domain; Region: RimM; pfam01782 491915005555 PRC-barrel domain; Region: PRC; pfam05239 491915005556 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 491915005557 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 491915005558 KH domain; Region: KH_4; pfam13083 491915005559 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 491915005560 signal recognition particle protein; Provisional; Region: PRK10867 491915005561 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 491915005562 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 491915005563 P loop; other site 491915005564 GTP binding site [chemical binding]; other site 491915005565 Signal peptide binding domain; Region: SRP_SPB; pfam02978 491915005566 putative DNA-binding protein; Validated; Region: PRK00118 491915005567 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 491915005568 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 491915005569 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 491915005570 P loop; other site 491915005571 GTP binding site [chemical binding]; other site 491915005572 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 491915005573 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 491915005574 Walker A/P-loop; other site 491915005575 ATP binding site [chemical binding]; other site 491915005576 Q-loop/lid; other site 491915005577 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 491915005578 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 491915005579 ABC transporter signature motif; other site 491915005580 Walker B; other site 491915005581 D-loop; other site 491915005582 H-loop/switch region; other site 491915005583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915005584 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915005585 Probable transposase; Region: OrfB_IS605; pfam01385 491915005586 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915005587 ribonuclease III; Reviewed; Region: rnc; PRK00102 491915005588 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 491915005589 dimerization interface [polypeptide binding]; other site 491915005590 active site 491915005591 metal binding site [ion binding]; metal-binding site 491915005592 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 491915005593 dsRNA binding site [nucleotide binding]; other site 491915005594 acyl carrier protein; Provisional; Region: acpP; PRK00982 491915005595 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 491915005596 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 491915005597 NAD(P) binding site [chemical binding]; other site 491915005598 homotetramer interface [polypeptide binding]; other site 491915005599 homodimer interface [polypeptide binding]; other site 491915005600 active site 491915005601 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 491915005602 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 491915005603 putative phosphate acyltransferase; Provisional; Region: PRK05331 491915005604 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 491915005605 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 491915005606 active site 2 [active] 491915005607 active site 1 [active] 491915005608 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 491915005609 Pathogenicity locus; Region: Cdd1; pfam11731 491915005610 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 491915005611 generic binding surface II; other site 491915005612 ssDNA binding site; other site 491915005613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915005614 ATP binding site [chemical binding]; other site 491915005615 putative Mg++ binding site [ion binding]; other site 491915005616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915005617 nucleotide binding region [chemical binding]; other site 491915005618 ATP-binding site [chemical binding]; other site 491915005619 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 491915005620 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 491915005621 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 491915005622 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 491915005623 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 491915005624 putative L-serine binding site [chemical binding]; other site 491915005625 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 491915005626 DAK2 domain; Region: Dak2; pfam02734 491915005627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 491915005628 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 491915005629 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 491915005630 Thiamine pyrophosphokinase; Region: TPK; cd07995 491915005631 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 491915005632 active site 491915005633 dimerization interface [polypeptide binding]; other site 491915005634 thiamine binding site [chemical binding]; other site 491915005635 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 491915005636 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 491915005637 substrate binding site [chemical binding]; other site 491915005638 hexamer interface [polypeptide binding]; other site 491915005639 metal binding site [ion binding]; metal-binding site 491915005640 GTPase RsgA; Reviewed; Region: PRK00098 491915005641 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 491915005642 RNA binding site [nucleotide binding]; other site 491915005643 homodimer interface [polypeptide binding]; other site 491915005644 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 491915005645 GTPase/Zn-binding domain interface [polypeptide binding]; other site 491915005646 GTP/Mg2+ binding site [chemical binding]; other site 491915005647 G4 box; other site 491915005648 G5 box; other site 491915005649 G1 box; other site 491915005650 Switch I region; other site 491915005651 G2 box; other site 491915005652 G3 box; other site 491915005653 Switch II region; other site 491915005654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 491915005655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 491915005656 active site 491915005657 ATP binding site [chemical binding]; other site 491915005658 substrate binding site [chemical binding]; other site 491915005659 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 491915005660 activation loop (A-loop); other site 491915005661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 491915005662 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 491915005663 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 491915005664 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 491915005665 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 491915005666 Protein phosphatase 2C; Region: PP2C; pfam00481 491915005667 active site 491915005668 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 491915005669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915005670 FeS/SAM binding site; other site 491915005671 16S rRNA methyltransferase B; Provisional; Region: PRK14902 491915005672 NusB family; Region: NusB; pfam01029 491915005673 putative RNA binding site [nucleotide binding]; other site 491915005674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915005675 S-adenosylmethionine binding site [chemical binding]; other site 491915005676 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 491915005677 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 491915005678 putative active site [active] 491915005679 substrate binding site [chemical binding]; other site 491915005680 putative cosubstrate binding site; other site 491915005681 catalytic site [active] 491915005682 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 491915005683 substrate binding site [chemical binding]; other site 491915005684 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 491915005685 active site 491915005686 catalytic residues [active] 491915005687 metal binding site [ion binding]; metal-binding site 491915005688 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 491915005689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915005690 ATP binding site [chemical binding]; other site 491915005691 putative Mg++ binding site [ion binding]; other site 491915005692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915005693 nucleotide binding region [chemical binding]; other site 491915005694 ATP-binding site [chemical binding]; other site 491915005695 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 491915005696 Flavoprotein; Region: Flavoprotein; pfam02441 491915005697 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 491915005698 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 491915005699 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 491915005700 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 491915005701 catalytic site [active] 491915005702 G-X2-G-X-G-K; other site 491915005703 hypothetical protein; Provisional; Region: PRK11820 491915005704 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 491915005705 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 491915005706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 491915005707 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 491915005708 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 491915005709 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 491915005710 Soluble P-type ATPase [General function prediction only]; Region: COG4087 491915005711 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 491915005712 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 491915005713 Domain of unknown function (DUF814); Region: DUF814; pfam05670 491915005714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915005715 active site 491915005716 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 491915005717 active site 491915005718 dimer interface [polypeptide binding]; other site 491915005719 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 491915005720 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 491915005721 heterodimer interface [polypeptide binding]; other site 491915005722 active site 491915005723 FMN binding site [chemical binding]; other site 491915005724 homodimer interface [polypeptide binding]; other site 491915005725 substrate binding site [chemical binding]; other site 491915005726 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 491915005727 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 491915005728 FAD binding pocket [chemical binding]; other site 491915005729 FAD binding motif [chemical binding]; other site 491915005730 phosphate binding motif [ion binding]; other site 491915005731 beta-alpha-beta structure motif; other site 491915005732 NAD binding pocket [chemical binding]; other site 491915005733 Iron coordination center [ion binding]; other site 491915005734 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 491915005735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915005736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 491915005737 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 491915005738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915005739 ATP-grasp domain; Region: ATP-grasp_4; cl17255 491915005740 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 491915005741 IMP binding site; other site 491915005742 dimer interface [polypeptide binding]; other site 491915005743 interdomain contacts; other site 491915005744 partial ornithine binding site; other site 491915005745 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 491915005746 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 491915005747 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 491915005748 catalytic site [active] 491915005749 subunit interface [polypeptide binding]; other site 491915005750 dihydroorotase; Validated; Region: pyrC; PRK09357 491915005751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 491915005752 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 491915005753 active site 491915005754 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 491915005755 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 491915005756 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 491915005757 uracil transporter; Provisional; Region: PRK10720 491915005758 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 491915005759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915005760 active site 491915005761 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 491915005762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915005763 RNA binding surface [nucleotide binding]; other site 491915005764 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 491915005765 active site 491915005766 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 491915005767 lipoprotein signal peptidase; Provisional; Region: PRK14787 491915005768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915005769 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915005770 Probable transposase; Region: OrfB_IS605; pfam01385 491915005771 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 491915005772 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 491915005773 HIGH motif; other site 491915005774 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 491915005775 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 491915005776 active site 491915005777 KMSKS motif; other site 491915005778 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 491915005779 tRNA binding surface [nucleotide binding]; other site 491915005780 anticodon binding site; other site 491915005781 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 491915005782 T-box leader; Aflv_R089 491915005783 DivIVA protein; Region: DivIVA; pfam05103 491915005784 DivIVA domain; Region: DivI1A_domain; TIGR03544 491915005785 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 491915005786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 491915005787 RNA binding surface [nucleotide binding]; other site 491915005788 YGGT family; Region: YGGT; pfam02325 491915005789 Protein of unknown function (DUF552); Region: DUF552; cl00775 491915005790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 491915005791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 491915005792 catalytic residue [active] 491915005793 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 491915005794 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 491915005795 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 491915005796 sporulation sigma factor SigG; Reviewed; Region: PRK08215 491915005797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915005798 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 491915005799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915005800 DNA binding residues [nucleotide binding] 491915005801 sporulation sigma factor SigE; Reviewed; Region: PRK08301 491915005802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915005803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915005804 DNA binding residues [nucleotide binding] 491915005805 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 491915005806 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 491915005807 cell division protein FtsZ; Validated; Region: PRK09330 491915005808 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 491915005809 nucleotide binding site [chemical binding]; other site 491915005810 SulA interaction site; other site 491915005811 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 491915005812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 491915005813 nucleotide binding site [chemical binding]; other site 491915005814 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 491915005815 Cell division protein FtsA; Region: FtsA; pfam14450 491915005816 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 491915005817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 491915005818 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 491915005819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 491915005820 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 491915005821 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 491915005822 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 491915005823 Cell division protein FtsQ; Region: FtsQ; pfam03799 491915005824 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 491915005825 FAD binding domain; Region: FAD_binding_4; pfam01565 491915005826 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 491915005827 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 491915005828 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 491915005829 active site 491915005830 homodimer interface [polypeptide binding]; other site 491915005831 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 491915005832 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 491915005833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 491915005834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 491915005835 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 491915005836 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 491915005837 Mg++ binding site [ion binding]; other site 491915005838 putative catalytic motif [active] 491915005839 putative substrate binding site [chemical binding]; other site 491915005840 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 491915005841 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 491915005842 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 491915005843 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 491915005844 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 491915005845 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 491915005846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 491915005847 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 491915005848 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 491915005849 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 491915005850 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 491915005851 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 491915005852 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 491915005853 Cell division protein FtsL; Region: FtsL; cl11433 491915005854 MraW methylase family; Region: Methyltransf_5; pfam01795 491915005855 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 491915005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 491915005857 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 491915005858 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 491915005859 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 491915005860 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 491915005861 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 491915005862 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 491915005863 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 491915005864 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 491915005865 substrate binding site [chemical binding]; other site 491915005866 oxyanion hole (OAH) forming residues; other site 491915005867 trimer interface [polypeptide binding]; other site 491915005868 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 491915005869 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 491915005870 hypothetical protein; Provisional; Region: PRK13670 491915005871 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 491915005872 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 491915005873 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 491915005874 protein binding site [polypeptide binding]; other site 491915005875 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 491915005876 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 491915005877 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 491915005878 active site 491915005879 nucleophile elbow; other site 491915005880 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 491915005881 Nucleoside recognition; Region: Gate; pfam07670 491915005882 Nucleoside recognition; Region: Gate; pfam07670 491915005883 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 491915005884 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 491915005885 active site 491915005886 (T/H)XGH motif; other site 491915005887 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 491915005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 491915005889 hypothetical protein; Provisional; Region: PRK02886 491915005890 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 491915005891 YlbE-like protein; Region: YlbE; pfam14003 491915005892 Putative coat protein; Region: YlbD_coat; pfam14071 491915005893 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 491915005894 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 491915005895 FOG: CBS domain [General function prediction only]; Region: COG0517 491915005896 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 491915005897 YugN-like family; Region: YugN; pfam08868 491915005898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 491915005899 Domain of unknown function DUF20; Region: UPF0118; pfam01594 491915005900 Protein of unknown function (DUF420); Region: DUF420; pfam04238 491915005901 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 491915005902 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 491915005903 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 491915005904 Subunit I/III interface [polypeptide binding]; other site 491915005905 Subunit III/IV interface [polypeptide binding]; other site 491915005906 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 491915005907 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 491915005908 D-pathway; other site 491915005909 Putative ubiquinol binding site [chemical binding]; other site 491915005910 Low-spin heme (heme b) binding site [chemical binding]; other site 491915005911 Putative water exit pathway; other site 491915005912 Binuclear center (heme o3/CuB) [ion binding]; other site 491915005913 K-pathway; other site 491915005914 Putative proton exit pathway; other site 491915005915 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 491915005916 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 491915005917 Cytochrome c; Region: Cytochrom_C; pfam00034 491915005918 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 491915005919 UbiA prenyltransferase family; Region: UbiA; pfam01040 491915005920 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 491915005921 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 491915005922 pyruvate carboxylase; Reviewed; Region: PRK12999 491915005923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915005924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 491915005925 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 491915005926 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 491915005927 active site 491915005928 catalytic residues [active] 491915005929 metal binding site [ion binding]; metal-binding site 491915005930 homodimer binding site [polypeptide binding]; other site 491915005931 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 491915005932 carboxyltransferase (CT) interaction site; other site 491915005933 biotinylation site [posttranslational modification]; other site 491915005934 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 491915005935 hypothetical protein; Provisional; Region: PRK13666 491915005936 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 491915005937 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 491915005938 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 491915005939 putative active site [active] 491915005940 PhoH-like protein; Region: PhoH; pfam02562 491915005941 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 491915005942 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 491915005943 hypothetical protein; Provisional; Region: PRK06733 491915005944 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 491915005945 YlaH-like protein; Region: YlaH; pfam14036 491915005946 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 491915005947 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 491915005948 putative GEF interaction site [polypeptide binding]; other site 491915005949 Switch I region; other site 491915005950 G2 box; other site 491915005951 G3 box; other site 491915005952 Switch II region; other site 491915005953 GTP/Mg2+ binding site [chemical binding]; other site 491915005954 G4 box; other site 491915005955 G5 box; other site 491915005956 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 491915005957 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 491915005958 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 491915005959 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 491915005960 active site 491915005961 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 491915005962 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 491915005963 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 491915005964 FMN binding site [chemical binding]; other site 491915005965 substrate binding site [chemical binding]; other site 491915005966 putative catalytic residue [active] 491915005967 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 491915005968 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 491915005969 homodimer interface [polypeptide binding]; other site 491915005970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915005971 catalytic residue [active] 491915005972 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 491915005973 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 491915005974 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 491915005975 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 491915005976 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 491915005977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915005978 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 491915005979 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 491915005980 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 491915005981 E3 interaction surface; other site 491915005982 lipoyl attachment site [posttranslational modification]; other site 491915005983 e3 binding domain; Region: E3_binding; pfam02817 491915005984 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 491915005985 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 491915005986 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 491915005987 alpha subunit interface [polypeptide binding]; other site 491915005988 TPP binding site [chemical binding]; other site 491915005989 heterodimer interface [polypeptide binding]; other site 491915005990 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 491915005991 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 491915005992 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 491915005993 TPP-binding site [chemical binding]; other site 491915005994 tetramer interface [polypeptide binding]; other site 491915005995 heterodimer interface [polypeptide binding]; other site 491915005996 phosphorylation loop region [posttranslational modification] 491915005997 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 491915005998 active site 491915005999 catalytic residues [active] 491915006000 metal binding site [ion binding]; metal-binding site 491915006001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006002 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 491915006003 active site 491915006004 motif I; other site 491915006005 motif II; other site 491915006006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006007 similar to hypothetical protein 491915006008 hypothetical protein; Provisional; Region: PRK13667 491915006009 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 491915006010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915006011 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 491915006012 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 491915006013 TrkA-N domain; Region: TrkA_N; pfam02254 491915006014 TrkA-C domain; Region: TrkA_C; pfam02080 491915006015 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 491915006016 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915006017 catalytic residues [active] 491915006018 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 491915006019 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 491915006020 metal binding site [ion binding]; metal-binding site 491915006021 putative dimer interface [polypeptide binding]; other site 491915006022 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 491915006023 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 491915006024 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 491915006025 trimer interface [polypeptide binding]; other site 491915006026 active site 491915006027 substrate binding site [chemical binding]; other site 491915006028 CoA binding site [chemical binding]; other site 491915006029 FOG: CBS domain [General function prediction only]; Region: COG0517 491915006030 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 491915006031 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 491915006032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915006033 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 491915006034 short chain dehydrogenase; Provisional; Region: PRK07677 491915006035 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 491915006036 NAD(P) binding site [chemical binding]; other site 491915006037 substrate binding site [chemical binding]; other site 491915006038 homotetramer interface [polypeptide binding]; other site 491915006039 active site 491915006040 homodimer interface [polypeptide binding]; other site 491915006041 phosphodiesterase YaeI; Provisional; Region: PRK11340 491915006042 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 491915006043 putative active site [active] 491915006044 putative metal binding site [ion binding]; other site 491915006045 CrcB-like protein; Region: CRCB; cl09114 491915006046 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 491915006047 polyphosphate kinase; Provisional; Region: PRK05443 491915006048 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 491915006049 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 491915006050 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 491915006051 putative domain interface [polypeptide binding]; other site 491915006052 putative active site [active] 491915006053 catalytic site [active] 491915006054 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 491915006055 putative domain interface [polypeptide binding]; other site 491915006056 putative active site [active] 491915006057 catalytic site [active] 491915006058 exopolyphosphatase; Region: exo_poly_only; TIGR03706 491915006059 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 491915006060 YkyB-like protein; Region: YkyB; pfam14177 491915006061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915006062 metal binding site [ion binding]; metal-binding site 491915006063 active site 491915006064 I-site; other site 491915006065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915006066 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 491915006067 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 491915006068 Spore germination protein; Region: Spore_permease; cl17796 491915006069 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915006070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915006071 dimerization interface [polypeptide binding]; other site 491915006072 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 491915006073 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 491915006074 PAS fold; Region: PAS_4; pfam08448 491915006075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006076 dimer interface [polypeptide binding]; other site 491915006077 phosphorylation site [posttranslational modification] 491915006078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006079 ATP binding site [chemical binding]; other site 491915006080 Mg2+ binding site [ion binding]; other site 491915006081 G-X-G motif; other site 491915006082 Response regulator receiver domain; Region: Response_reg; pfam00072 491915006083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006084 active site 491915006085 phosphorylation site [posttranslational modification] 491915006086 intermolecular recognition site; other site 491915006087 dimerization interface [polypeptide binding]; other site 491915006088 Response regulator receiver domain; Region: Response_reg; pfam00072 491915006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006090 active site 491915006091 phosphorylation site [posttranslational modification] 491915006092 intermolecular recognition site; other site 491915006093 dimerization interface [polypeptide binding]; other site 491915006094 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 491915006095 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 491915006096 DXD motif; other site 491915006097 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 491915006098 HEAT repeats; Region: HEAT_2; pfam13646 491915006099 HEAT repeats; Region: HEAT_2; pfam13646 491915006100 Hpt domain; Region: Hpt; pfam01627 491915006101 putative binding surface; other site 491915006102 active site 491915006103 Response regulator receiver domain; Region: Response_reg; pfam00072 491915006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006105 active site 491915006106 phosphorylation site [posttranslational modification] 491915006107 intermolecular recognition site; other site 491915006108 dimerization interface [polypeptide binding]; other site 491915006109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915006110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915006111 metal binding site [ion binding]; metal-binding site 491915006112 active site 491915006113 I-site; other site 491915006114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915006116 active site 491915006117 phosphorylation site [posttranslational modification] 491915006118 intermolecular recognition site; other site 491915006119 dimerization interface [polypeptide binding]; other site 491915006120 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 491915006121 putative CheA interaction surface; other site 491915006122 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 491915006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006124 active site 491915006125 phosphorylation site [posttranslational modification] 491915006126 intermolecular recognition site; other site 491915006127 dimerization interface [polypeptide binding]; other site 491915006128 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 491915006129 active site 491915006130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915006131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915006132 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 491915006133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006134 dimer interface [polypeptide binding]; other site 491915006135 phosphorylation site [posttranslational modification] 491915006136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006137 ATP binding site [chemical binding]; other site 491915006138 Mg2+ binding site [ion binding]; other site 491915006139 G-X-G motif; other site 491915006140 IDEAL domain; Region: IDEAL; pfam08858 491915006141 aminotransferase A; Validated; Region: PRK07683 491915006142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915006144 homodimer interface [polypeptide binding]; other site 491915006145 catalytic residue [active] 491915006146 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 491915006147 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 491915006148 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 491915006149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 491915006150 putative NAD(P) binding site [chemical binding]; other site 491915006151 putative active site [active] 491915006152 Response regulator receiver domain; Region: Response_reg; pfam00072 491915006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006154 active site 491915006155 phosphorylation site [posttranslational modification] 491915006156 intermolecular recognition site; other site 491915006157 dimerization interface [polypeptide binding]; other site 491915006158 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915006159 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915006160 metal binding site [ion binding]; metal-binding site 491915006161 active site 491915006162 I-site; other site 491915006163 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 491915006164 GAF domain; Region: GAF; pfam01590 491915006165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 491915006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006167 dimer interface [polypeptide binding]; other site 491915006168 phosphorylation site [posttranslational modification] 491915006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006170 ATP binding site [chemical binding]; other site 491915006171 Mg2+ binding site [ion binding]; other site 491915006172 G-X-G motif; other site 491915006173 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 491915006174 Cache domain; Region: Cache_1; pfam02743 491915006175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915006176 dimerization interface [polypeptide binding]; other site 491915006177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006178 dimer interface [polypeptide binding]; other site 491915006179 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915006180 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006181 dimer interface [polypeptide binding]; other site 491915006182 putative CheW interface [polypeptide binding]; other site 491915006183 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 491915006184 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 491915006185 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 491915006186 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 491915006187 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 491915006188 dimerization domain swap beta strand [polypeptide binding]; other site 491915006189 regulatory protein interface [polypeptide binding]; other site 491915006190 active site 491915006191 regulatory phosphorylation site [posttranslational modification]; other site 491915006192 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 491915006193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 491915006194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 491915006195 active site turn [active] 491915006196 phosphorylation site [posttranslational modification] 491915006197 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 491915006198 HPr interaction site; other site 491915006199 glycerol kinase (GK) interaction site [polypeptide binding]; other site 491915006200 active site 491915006201 phosphorylation site [posttranslational modification] 491915006202 transcriptional antiterminator BglG; Provisional; Region: PRK09772 491915006203 CAT RNA binding domain; Region: CAT_RBD; smart01061 491915006204 PRD domain; Region: PRD; pfam00874 491915006205 PRD domain; Region: PRD; pfam00874 491915006206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006207 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 491915006208 active site 491915006209 motif I; other site 491915006210 motif II; other site 491915006211 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 491915006212 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915006213 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 491915006214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915006215 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 491915006216 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 491915006217 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 491915006218 NlpC/P60 family; Region: NLPC_P60; pfam00877 491915006219 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 491915006220 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 491915006221 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 491915006222 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 491915006223 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 491915006224 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 491915006225 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 491915006226 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 491915006227 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 491915006228 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 491915006229 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 491915006230 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 491915006231 heme-binding site [chemical binding]; other site 491915006232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915006233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006234 dimer interface [polypeptide binding]; other site 491915006235 putative CheW interface [polypeptide binding]; other site 491915006236 YvrJ protein family; Region: YvrJ; pfam12841 491915006237 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 491915006238 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 491915006239 Predicted transcriptional regulators [Transcription]; Region: COG1733 491915006240 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 491915006241 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 491915006242 dimer interface [polypeptide binding]; other site 491915006243 FMN binding site [chemical binding]; other site 491915006244 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 491915006245 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006246 putative active site [active] 491915006247 heme pocket [chemical binding]; other site 491915006248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006249 dimer interface [polypeptide binding]; other site 491915006250 phosphorylation site [posttranslational modification] 491915006251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006252 ATP binding site [chemical binding]; other site 491915006253 Mg2+ binding site [ion binding]; other site 491915006254 G-X-G motif; other site 491915006255 YueH-like protein; Region: YueH; pfam14166 491915006256 RNA polymerase factor sigma-70; Validated; Region: PRK06759 491915006257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 491915006258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 491915006259 DNA binding residues [nucleotide binding] 491915006260 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 491915006261 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 491915006262 NADH(P)-binding; Region: NAD_binding_10; pfam13460 491915006263 NAD binding site [chemical binding]; other site 491915006264 active site 491915006265 authentic frameshift 491915006266 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 491915006267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915006268 FeS/SAM binding site; other site 491915006269 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 491915006270 active site 491915006271 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 491915006272 Ligand Binding Site [chemical binding]; other site 491915006273 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 491915006274 PhoU domain; Region: PhoU; pfam01895 491915006275 PhoU domain; Region: PhoU; pfam01895 491915006276 Uncharacterized membrane protein [Function unknown]; Region: COG3949 491915006277 YtkA-like; Region: YtkA; pfam13115 491915006278 SPRY domain; Region: SPRY; cl02614 491915006279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915006280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915006281 active site 491915006282 phosphorylation site [posttranslational modification] 491915006283 intermolecular recognition site; other site 491915006284 dimerization interface [polypeptide binding]; other site 491915006285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 491915006286 DNA binding site [nucleotide binding] 491915006287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 491915006288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915006289 dimerization interface [polypeptide binding]; other site 491915006290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006291 dimer interface [polypeptide binding]; other site 491915006292 phosphorylation site [posttranslational modification] 491915006293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006294 ATP binding site [chemical binding]; other site 491915006295 Mg2+ binding site [ion binding]; other site 491915006296 G-X-G motif; other site 491915006297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006298 PAS domain; Region: PAS_9; pfam13426 491915006299 putative active site [active] 491915006300 heme pocket [chemical binding]; other site 491915006301 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915006302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006303 dimer interface [polypeptide binding]; other site 491915006304 putative CheW interface [polypeptide binding]; other site 491915006305 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 491915006306 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 491915006307 cofactor binding site; other site 491915006308 DNA binding site [nucleotide binding] 491915006309 substrate interaction site [chemical binding]; other site 491915006310 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 491915006311 Restriction endonuclease MspI; Region: Endonuc-MspI; pfam09208 491915006312 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 491915006313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915006314 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 491915006315 Walker A motif; other site 491915006316 ATP binding site [chemical binding]; other site 491915006317 Walker B motif; other site 491915006318 arginine finger; other site 491915006319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915006320 AAA domain; Region: AAA_22; pfam13401 491915006321 Walker A motif; other site 491915006322 ATP binding site [chemical binding]; other site 491915006323 Walker B motif; other site 491915006324 arginine finger; other site 491915006325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 491915006326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915006327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915006328 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 491915006329 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 491915006330 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 491915006331 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 491915006332 Walker A/P-loop; other site 491915006333 ATP binding site [chemical binding]; other site 491915006334 Q-loop/lid; other site 491915006335 ABC transporter signature motif; other site 491915006336 Walker B; other site 491915006337 D-loop; other site 491915006338 H-loop/switch region; other site 491915006339 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 491915006340 Spore germination protein; Region: Spore_permease; cl17796 491915006341 PemK-like protein; Region: PemK; pfam02452 491915006342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006343 dimer interface [polypeptide binding]; other site 491915006344 phosphorylation site [posttranslational modification] 491915006345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006346 ATP binding site [chemical binding]; other site 491915006347 Mg2+ binding site [ion binding]; other site 491915006348 G-X-G motif; other site 491915006349 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 491915006350 ARD/ARD' family; Region: ARD; pfam03079 491915006351 Cupin domain; Region: Cupin_2; cl17218 491915006352 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 491915006353 intersubunit interface [polypeptide binding]; other site 491915006354 active site 491915006355 Zn2+ binding site [ion binding]; other site 491915006356 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 491915006357 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 491915006358 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 491915006359 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 491915006360 dimer interface [polypeptide binding]; other site 491915006361 active site 491915006362 catalytic residue [active] 491915006363 metal binding site [ion binding]; metal-binding site 491915006364 transaminase; Reviewed; Region: PRK08068 491915006365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915006366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915006367 homodimer interface [polypeptide binding]; other site 491915006368 catalytic residue [active] 491915006369 Predicted amidohydrolase [General function prediction only]; Region: COG0388 491915006370 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 491915006371 putative active site [active] 491915006372 catalytic triad [active] 491915006373 putative dimer interface [polypeptide binding]; other site 491915006374 Phosphotransferase enzyme family; Region: APH; pfam01636 491915006375 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 491915006376 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 491915006377 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 491915006378 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 491915006379 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 491915006380 putative ligand binding site [chemical binding]; other site 491915006381 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 491915006382 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 491915006383 Walker A/P-loop; other site 491915006384 ATP binding site [chemical binding]; other site 491915006385 Q-loop/lid; other site 491915006386 ABC transporter signature motif; other site 491915006387 Walker B; other site 491915006388 D-loop; other site 491915006389 H-loop/switch region; other site 491915006390 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 491915006391 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 491915006392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915006393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 491915006394 TM-ABC transporter signature motif; other site 491915006395 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915006396 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006397 dimer interface [polypeptide binding]; other site 491915006398 putative CheW interface [polypeptide binding]; other site 491915006399 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 491915006400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006401 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 491915006402 putative active site [active] 491915006403 heme pocket [chemical binding]; other site 491915006404 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 491915006405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006406 putative active site [active] 491915006407 heme pocket [chemical binding]; other site 491915006408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006409 putative active site [active] 491915006410 heme pocket [chemical binding]; other site 491915006411 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 491915006412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915006413 putative active site [active] 491915006414 heme pocket [chemical binding]; other site 491915006415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006416 dimer interface [polypeptide binding]; other site 491915006417 phosphorylation site [posttranslational modification] 491915006418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006419 ATP binding site [chemical binding]; other site 491915006420 Mg2+ binding site [ion binding]; other site 491915006421 G-X-G motif; other site 491915006422 Uncharacterized conserved protein [Function unknown]; Region: COG1556 491915006423 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 491915006424 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 491915006425 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 491915006426 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 491915006427 Cysteine-rich domain; Region: CCG; pfam02754 491915006428 Cysteine-rich domain; Region: CCG; pfam02754 491915006429 Transcriptional regulators [Transcription]; Region: FadR; COG2186 491915006430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 491915006431 DNA-binding site [nucleotide binding]; DNA binding site 491915006432 FCD domain; Region: FCD; pfam07729 491915006433 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 491915006434 L-lactate permease; Region: Lactate_perm; cl00701 491915006435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915006436 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915006437 Probable transposase; Region: OrfB_IS605; pfam01385 491915006438 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915006439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 491915006440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915006441 AAA domain; Region: AAA_21; pfam13304 491915006442 Walker A/P-loop; other site 491915006443 ATP binding site [chemical binding]; other site 491915006444 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 491915006445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915006446 Radical SAM superfamily; Region: Radical_SAM; pfam04055 491915006447 FeS/SAM binding site; other site 491915006448 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 491915006449 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 491915006450 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 491915006451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 491915006452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006453 dimer interface [polypeptide binding]; other site 491915006454 conserved gate region; other site 491915006455 putative PBP binding loops; other site 491915006456 ABC-ATPase subunit interface; other site 491915006457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006458 dimer interface [polypeptide binding]; other site 491915006459 conserved gate region; other site 491915006460 putative PBP binding loops; other site 491915006461 ABC-ATPase subunit interface; other site 491915006462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 491915006463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 491915006464 beta-phosphoglucomutase; Region: bPGM; TIGR01990 491915006465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006466 motif II; other site 491915006467 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 491915006468 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 491915006469 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 491915006470 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 491915006471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 491915006472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915006473 DNA binding site [nucleotide binding] 491915006474 domain linker motif; other site 491915006475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 491915006476 dimerization interface [polypeptide binding]; other site 491915006477 ligand binding site [chemical binding]; other site 491915006478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915006479 dimerization interface [polypeptide binding]; other site 491915006480 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915006481 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006482 dimer interface [polypeptide binding]; other site 491915006483 putative CheW interface [polypeptide binding]; other site 491915006484 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 491915006485 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 491915006486 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 491915006487 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 491915006488 FAD binding domain; Region: FAD_binding_4; pfam01565 491915006489 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 491915006490 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 491915006491 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 491915006492 Cysteine-rich domain; Region: CCG; pfam02754 491915006493 Cysteine-rich domain; Region: CCG; pfam02754 491915006494 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 491915006495 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 491915006496 Ferritin-like domain; Region: Ferritin; pfam00210 491915006497 ferroxidase diiron center [ion binding]; other site 491915006498 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 491915006499 yybP-yko_riboswitch; Aflv_R092 491915006500 amino acid transporter; Region: 2A0306; TIGR00909 491915006501 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 491915006502 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 491915006503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 491915006504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915006505 dimer interface [polypeptide binding]; other site 491915006506 phosphorylation site [posttranslational modification] 491915006507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915006508 ATP binding site [chemical binding]; other site 491915006509 Mg2+ binding site [ion binding]; other site 491915006510 G-X-G motif; other site 491915006511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915006512 putative substrate translocation pore; other site 491915006513 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915006514 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 491915006515 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 491915006516 Ligand binding site; other site 491915006517 Putative Catalytic site; other site 491915006518 DXD motif; other site 491915006519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915006520 S-adenosylmethionine binding site [chemical binding]; other site 491915006521 azoreductase; Reviewed; Region: PRK00170 491915006522 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 491915006523 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 491915006524 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 491915006525 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 491915006526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 491915006527 active site 491915006528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 491915006529 dimer interface [polypeptide binding]; other site 491915006530 substrate binding site [chemical binding]; other site 491915006531 catalytic residue [active] 491915006532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 491915006533 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 491915006534 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 491915006535 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 491915006536 Malic enzyme, N-terminal domain; Region: malic; pfam00390 491915006537 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 491915006538 putative NAD(P) binding site [chemical binding]; other site 491915006539 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 491915006540 Aspartase; Region: Aspartase; cd01357 491915006541 active sites [active] 491915006542 tetramer interface [polypeptide binding]; other site 491915006543 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 491915006544 active site 491915006545 homodimer interface [polypeptide binding]; other site 491915006546 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 491915006547 Catalytic domain of Protein Kinases; Region: PKc; cd00180 491915006548 active site 491915006549 ATP binding site [chemical binding]; other site 491915006550 substrate binding site [chemical binding]; other site 491915006551 activation loop (A-loop); other site 491915006552 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 491915006553 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 491915006554 EamA-like transporter family; Region: EamA; pfam00892 491915006555 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 491915006556 EamA-like transporter family; Region: EamA; pfam00892 491915006557 DDE superfamily endonuclease; Region: DDE_5; cl17874 491915006558 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915006559 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 491915006560 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 491915006561 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 491915006562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915006563 ATP binding site [chemical binding]; other site 491915006564 putative Mg++ binding site [ion binding]; other site 491915006565 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 491915006566 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 491915006567 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 491915006568 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 491915006569 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 491915006570 HsdM N-terminal domain; Region: HsdM_N; pfam12161 491915006571 Methyltransferase domain; Region: Methyltransf_26; pfam13659 491915006572 S-adenosylmethionine binding site [chemical binding]; other site 491915006573 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 491915006574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915006575 hypothetical protein; Region: PHA00728 491915006576 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915006577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915006578 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915006579 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 491915006580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915006581 Zn2+ binding site [ion binding]; other site 491915006582 Mg2+ binding site [ion binding]; other site 491915006583 cystathionine beta-lyase; Provisional; Region: PRK08064 491915006584 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 491915006585 homodimer interface [polypeptide binding]; other site 491915006586 substrate-cofactor binding pocket; other site 491915006587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915006588 catalytic residue [active] 491915006589 cystathionine gamma-synthase; Reviewed; Region: PRK08247 491915006590 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 491915006591 homodimer interface [polypeptide binding]; other site 491915006592 substrate-cofactor binding pocket; other site 491915006593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915006594 catalytic residue [active] 491915006595 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 491915006596 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 491915006597 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 491915006598 putative active site [active] 491915006599 metal binding site [ion binding]; metal-binding site 491915006600 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 491915006601 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 491915006602 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 491915006603 tetramer interfaces [polypeptide binding]; other site 491915006604 binuclear metal-binding site [ion binding]; other site 491915006605 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 491915006606 Putative esterase; Region: Esterase; pfam00756 491915006607 hypothetical protein; Provisional; Region: PRK13679 491915006608 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 491915006609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 491915006610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 491915006611 Coenzyme A binding pocket [chemical binding]; other site 491915006612 Predicted membrane protein [Function unknown]; Region: COG2323 491915006613 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 491915006614 Part of AAA domain; Region: AAA_19; pfam13245 491915006615 Family description; Region: UvrD_C_2; pfam13538 491915006616 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 491915006617 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 491915006618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 491915006619 catalytic residues [active] 491915006620 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 491915006621 Predicted membrane protein [Function unknown]; Region: COG2323 491915006622 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 491915006623 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 491915006624 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 491915006625 stage V sporulation protein AD; Provisional; Region: PRK12404 491915006626 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 491915006627 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 491915006628 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 491915006629 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 491915006630 Bacteriophage holin; Region: Phage_holin_1; cl02344 491915006631 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 491915006632 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 491915006633 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 491915006634 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 491915006635 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 491915006636 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 491915006637 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 491915006638 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 491915006639 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 491915006640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 491915006641 NAD(P) binding site [chemical binding]; other site 491915006642 active site 491915006643 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 491915006644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 491915006645 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 491915006646 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 491915006647 Protein of unknown function (DUF692); Region: DUF692; cl01263 491915006648 hypothetical protein; Region: PHA00728 491915006649 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915006650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915006651 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915006652 putative transposase OrfB; Reviewed; Region: PHA02517 491915006653 HTH-like domain; Region: HTH_21; pfam13276 491915006654 Integrase core domain; Region: rve; pfam00665 491915006655 Integrase core domain; Region: rve_2; pfam13333 491915006656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 491915006657 Transposase; Region: DDE_Tnp_ISL3; pfam01610 491915006658 DDE superfamily endonuclease; Region: DDE_5; cl17874 491915006659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915006660 H+ Antiporter protein; Region: 2A0121; TIGR00900 491915006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915006662 putative substrate translocation pore; other site 491915006663 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 491915006664 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 491915006665 NAD binding site [chemical binding]; other site 491915006666 homotetramer interface [polypeptide binding]; other site 491915006667 homodimer interface [polypeptide binding]; other site 491915006668 substrate binding site [chemical binding]; other site 491915006669 active site 491915006670 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 491915006671 MgtE intracellular N domain; Region: MgtE_N; pfam03448 491915006672 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 491915006673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 491915006674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 491915006675 Divalent cation transporter; Region: MgtE; pfam01769 491915006676 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 491915006677 Putative amidase domain; Region: Amidase_6; pfam12671 491915006678 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 491915006679 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 491915006680 active site 491915006681 metal binding site [ion binding]; metal-binding site 491915006682 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 491915006683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 491915006684 RNA binding surface [nucleotide binding]; other site 491915006685 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 491915006686 active site 491915006687 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 491915006688 ATP-NAD kinase; Region: NAD_kinase; pfam01513 491915006689 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 491915006690 synthetase active site [active] 491915006691 NTP binding site [chemical binding]; other site 491915006692 metal binding site [ion binding]; metal-binding site 491915006693 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 491915006694 putative active site [active] 491915006695 putative metal binding residues [ion binding]; other site 491915006696 signature motif; other site 491915006697 putative triphosphate binding site [ion binding]; other site 491915006698 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 491915006699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 491915006700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 491915006701 catalytic residue [active] 491915006702 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 491915006703 apolar tunnel; other site 491915006704 heme binding site [chemical binding]; other site 491915006705 dimerization interface [polypeptide binding]; other site 491915006706 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 491915006707 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 491915006708 catalytic residues [active] 491915006709 oligoendopeptidase F; Region: pepF; TIGR00181 491915006710 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 491915006711 active site 491915006712 Zn binding site [ion binding]; other site 491915006713 Competence protein CoiA-like family; Region: CoiA; cl11541 491915006714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915006715 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915006716 Probable transposase; Region: OrfB_IS605; pfam01385 491915006717 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915006718 adaptor protein; Provisional; Region: PRK02315 491915006719 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 491915006720 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 491915006721 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 491915006722 putative active site [active] 491915006723 catalytic site [active] 491915006724 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 491915006725 putative active site [active] 491915006726 catalytic site [active] 491915006727 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 491915006728 ArsC family; Region: ArsC; pfam03960 491915006729 putative catalytic residues [active] 491915006730 thiol/disulfide switch; other site 491915006731 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 491915006732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 491915006733 Walker A/P-loop; other site 491915006734 ATP binding site [chemical binding]; other site 491915006735 Q-loop/lid; other site 491915006736 ABC transporter signature motif; other site 491915006737 Walker B; other site 491915006738 D-loop; other site 491915006739 H-loop/switch region; other site 491915006740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 491915006741 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 491915006742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 491915006743 Walker A/P-loop; other site 491915006744 ATP binding site [chemical binding]; other site 491915006745 Q-loop/lid; other site 491915006746 ABC transporter signature motif; other site 491915006747 Walker B; other site 491915006748 D-loop; other site 491915006749 H-loop/switch region; other site 491915006750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 491915006751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 491915006752 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 491915006753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006754 dimer interface [polypeptide binding]; other site 491915006755 conserved gate region; other site 491915006756 putative PBP binding loops; other site 491915006757 ABC-ATPase subunit interface; other site 491915006758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 491915006759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006760 dimer interface [polypeptide binding]; other site 491915006761 conserved gate region; other site 491915006762 putative PBP binding loops; other site 491915006763 ABC-ATPase subunit interface; other site 491915006764 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 491915006765 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 491915006766 peptide binding site [polypeptide binding]; other site 491915006767 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 491915006768 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 491915006769 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 491915006770 active site 491915006771 HIGH motif; other site 491915006772 dimer interface [polypeptide binding]; other site 491915006773 KMSKS motif; other site 491915006774 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 491915006775 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 491915006776 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 491915006777 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 491915006778 dimer interface [polypeptide binding]; other site 491915006779 active site 491915006780 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 491915006781 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 491915006782 dimer interface [polypeptide binding]; other site 491915006783 active site 491915006784 CoA binding pocket [chemical binding]; other site 491915006785 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 491915006786 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 491915006787 putative ligand binding site [chemical binding]; other site 491915006788 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 491915006789 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 491915006790 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 491915006791 Clp amino terminal domain; Region: Clp_N; pfam02861 491915006792 Clp amino terminal domain; Region: Clp_N; pfam02861 491915006793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915006794 Walker A motif; other site 491915006795 ATP binding site [chemical binding]; other site 491915006796 Walker B motif; other site 491915006797 arginine finger; other site 491915006798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915006799 Walker A motif; other site 491915006800 ATP binding site [chemical binding]; other site 491915006801 Walker B motif; other site 491915006802 arginine finger; other site 491915006803 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 491915006804 YjzC-like protein; Region: YjzC; pfam14168 491915006805 ornithine carbamoyltransferase; Provisional; Region: PRK00779 491915006806 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 491915006807 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 491915006808 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 491915006809 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915006810 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 491915006811 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 491915006812 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 491915006813 ATP-grasp domain; Region: ATP-grasp_4; cl17255 491915006814 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 491915006815 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 491915006816 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 491915006817 catalytic site [active] 491915006818 subunit interface [polypeptide binding]; other site 491915006819 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915006820 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 491915006821 inhibitor-cofactor binding pocket; inhibition site 491915006822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915006823 catalytic residue [active] 491915006824 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 491915006825 nucleotide binding site [chemical binding]; other site 491915006826 N-acetyl-L-glutamate binding site [chemical binding]; other site 491915006827 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 491915006828 heterotetramer interface [polypeptide binding]; other site 491915006829 active site pocket [active] 491915006830 cleavage site 491915006831 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 491915006832 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 491915006833 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 491915006834 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 491915006835 ligand binding site [chemical binding]; other site 491915006836 flexible hinge region; other site 491915006837 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 491915006838 putative switch regulator; other site 491915006839 non-specific DNA interactions [nucleotide binding]; other site 491915006840 DNA binding site [nucleotide binding] 491915006841 sequence specific DNA binding site [nucleotide binding]; other site 491915006842 putative cAMP binding site [chemical binding]; other site 491915006843 YwiC-like protein; Region: YwiC; pfam14256 491915006844 esterase; Provisional; Region: PRK10566 491915006845 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 491915006846 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 491915006847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006848 motif II; other site 491915006849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915006850 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 491915006851 Uncharacterized conserved protein [Function unknown]; Region: COG1284 491915006852 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915006853 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915006854 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 491915006855 EDD domain protein, DegV family; Region: DegV; TIGR00762 491915006856 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 491915006857 Domain of unknown function (DUF3941); Region: DUF3941; pfam13081 491915006858 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915006859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915006860 dimerization interface [polypeptide binding]; other site 491915006861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915006862 dimer interface [polypeptide binding]; other site 491915006863 putative CheW interface [polypeptide binding]; other site 491915006864 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 491915006865 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 491915006866 ligand binding site [chemical binding]; other site 491915006867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 491915006868 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 491915006869 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 491915006870 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 491915006871 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 491915006872 FAD binding site [chemical binding]; other site 491915006873 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 491915006874 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 491915006875 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 491915006876 substrate binding pocket [chemical binding]; other site 491915006877 dimer interface [polypeptide binding]; other site 491915006878 inhibitor binding site; inhibition site 491915006879 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 491915006880 B12 binding site [chemical binding]; other site 491915006881 cobalt ligand [ion binding]; other site 491915006882 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 491915006883 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 491915006884 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 491915006885 Walker A motif; other site 491915006886 homodimer interface [polypeptide binding]; other site 491915006887 ATP binding site [chemical binding]; other site 491915006888 hydroxycobalamin binding site [chemical binding]; other site 491915006889 Walker B motif; other site 491915006890 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 491915006891 active site 491915006892 SAM binding site [chemical binding]; other site 491915006893 homodimer interface [polypeptide binding]; other site 491915006894 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 491915006895 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 491915006896 putative dimer interface [polypeptide binding]; other site 491915006897 active site pocket [active] 491915006898 putative cataytic base [active] 491915006899 cobyric acid synthase; Provisional; Region: PRK00784 491915006900 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915006901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915006902 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 491915006903 catalytic triad [active] 491915006904 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 491915006905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915006906 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 491915006907 catalytic triad [active] 491915006908 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 491915006909 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 491915006910 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 491915006911 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 491915006912 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 491915006913 active site 491915006914 SAM binding site [chemical binding]; other site 491915006915 homodimer interface [polypeptide binding]; other site 491915006916 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 491915006917 active site 491915006918 SAM binding site [chemical binding]; other site 491915006919 homodimer interface [polypeptide binding]; other site 491915006920 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 491915006921 active site 491915006922 putative homodimer interface [polypeptide binding]; other site 491915006923 SAM binding site [chemical binding]; other site 491915006924 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 491915006925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915006926 S-adenosylmethionine binding site [chemical binding]; other site 491915006927 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 491915006928 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 491915006929 Precorrin-8X methylmutase; Region: CbiC; pfam02570 491915006930 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 491915006931 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 491915006932 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 491915006933 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 491915006934 putative active site [active] 491915006935 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 491915006936 putative active site [active] 491915006937 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 491915006938 active site 491915006939 SAM binding site [chemical binding]; other site 491915006940 homodimer interface [polypeptide binding]; other site 491915006941 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 491915006942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 491915006943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915006944 Walker A/P-loop; other site 491915006945 ATP binding site [chemical binding]; other site 491915006946 Q-loop/lid; other site 491915006947 ABC transporter signature motif; other site 491915006948 Walker B; other site 491915006949 D-loop; other site 491915006950 H-loop/switch region; other site 491915006951 Cobalt transport protein; Region: CbiQ; cl00463 491915006952 cobalt transport protein CbiN; Provisional; Region: PRK02898 491915006953 cobalt transport protein CbiM; Validated; Region: PRK08319 491915006954 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 491915006955 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 491915006956 dimer interface [polypeptide binding]; other site 491915006957 [2Fe-2S] cluster binding site [ion binding]; other site 491915006958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 491915006959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915006960 DNA binding site [nucleotide binding] 491915006961 domain linker motif; other site 491915006962 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 491915006963 putative dimerization interface [polypeptide binding]; other site 491915006964 putative ligand binding site [chemical binding]; other site 491915006965 putative alpha-glucosidase; Provisional; Region: PRK10658 491915006966 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 491915006967 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 491915006968 trimer interface [polypeptide binding]; other site 491915006969 active site 491915006970 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 491915006971 catalytic site [active] 491915006972 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 491915006973 trehalose synthase; Region: treS_nterm; TIGR02456 491915006974 active site 491915006975 catalytic site [active] 491915006976 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 491915006977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006978 dimer interface [polypeptide binding]; other site 491915006979 conserved gate region; other site 491915006980 putative PBP binding loops; other site 491915006981 ABC-ATPase subunit interface; other site 491915006982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915006983 dimer interface [polypeptide binding]; other site 491915006984 conserved gate region; other site 491915006985 putative PBP binding loops; other site 491915006986 ABC-ATPase subunit interface; other site 491915006987 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 491915006988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 491915006989 maltodextrin glucosidase; Provisional; Region: PRK10785 491915006990 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 491915006991 homodimer interface [polypeptide binding]; other site 491915006992 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 491915006993 active site 491915006994 homodimer interface [polypeptide binding]; other site 491915006995 catalytic site [active] 491915006996 Cupin domain; Region: Cupin_2; cl17218 491915006997 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 491915006998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 491915006999 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 491915007000 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 491915007001 phytoene desaturase; Region: crtI_fam; TIGR02734 491915007002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915007003 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 491915007004 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 491915007005 active site 491915007006 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 491915007007 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 491915007008 putative acyl-acceptor binding pocket; other site 491915007009 Protein of unknown function (DUF422); Region: DUF422; cl00991 491915007010 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 491915007011 active site lid residues [active] 491915007012 substrate binding pocket [chemical binding]; other site 491915007013 catalytic residues [active] 491915007014 substrate-Mg2+ binding site; other site 491915007015 aspartate-rich region 1; other site 491915007016 aspartate-rich region 2; other site 491915007017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915007018 phytoene desaturase; Region: crtI_fam; TIGR02734 491915007019 phytoene desaturase; Region: crtI_fam; TIGR02734 491915007020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915007021 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 491915007022 active site 491915007023 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 491915007024 dimer interface [polypeptide binding]; other site 491915007025 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 491915007026 Ligand Binding Site [chemical binding]; other site 491915007027 Molecular Tunnel; other site 491915007028 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 491915007029 PAS domain S-box; Region: sensory_box; TIGR00229 491915007030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915007031 putative active site [active] 491915007032 heme pocket [chemical binding]; other site 491915007033 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 491915007034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915007035 metal binding site [ion binding]; metal-binding site 491915007036 active site 491915007037 I-site; other site 491915007038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915007039 hypothetical protein; Provisional; Region: PRK13673 491915007040 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 491915007041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 491915007042 inhibitor-cofactor binding pocket; inhibition site 491915007043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915007044 catalytic residue [active] 491915007045 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 491915007046 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 491915007047 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 491915007048 Predicted membrane protein [Function unknown]; Region: COG2311 491915007049 Protein of unknown function (DUF418); Region: DUF418; cl12135 491915007050 Protein of unknown function (DUF418); Region: DUF418; pfam04235 491915007051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915007052 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915007053 Probable transposase; Region: OrfB_IS605; pfam01385 491915007054 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915007055 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 491915007056 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 491915007057 DNA binding residues [nucleotide binding] 491915007058 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 491915007059 catalytic residues [active] 491915007060 catalytic nucleophile [active] 491915007061 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 491915007062 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 491915007063 Winged helix-turn helix; Region: HTH_29; pfam13551 491915007064 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915007065 Winged helix-turn helix; Region: HTH_33; pfam13592 491915007066 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915007067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915007068 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 491915007069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915007070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915007071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915007072 DNA binding residues [nucleotide binding] 491915007073 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 491915007074 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 491915007075 acyl-activating enzyme (AAE) consensus motif; other site 491915007076 putative active site [active] 491915007077 AMP binding site [chemical binding]; other site 491915007078 putative CoA binding site [chemical binding]; other site 491915007079 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 491915007080 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 491915007081 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 491915007082 Spore germination protein GerPC; Region: GerPC; pfam10737 491915007083 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 491915007084 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 491915007085 HNH endonuclease; Region: HNH; pfam01844 491915007086 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 491915007087 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 491915007088 Walker A/P-loop; other site 491915007089 ATP binding site [chemical binding]; other site 491915007090 Q-loop/lid; other site 491915007091 ABC transporter signature motif; other site 491915007092 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 491915007093 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 491915007094 ABC transporter signature motif; other site 491915007095 Walker B; other site 491915007096 D-loop; other site 491915007097 H-loop/switch region; other site 491915007098 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 491915007099 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 491915007100 active site 491915007101 metal binding site [ion binding]; metal-binding site 491915007102 DNA binding site [nucleotide binding] 491915007103 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 491915007104 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 491915007105 Part of AAA domain; Region: AAA_19; pfam13245 491915007106 Family description; Region: UvrD_C_2; pfam13538 491915007107 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 491915007108 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 491915007109 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 491915007110 Uncharacterized conserved protein [Function unknown]; Region: COG0398 491915007111 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 491915007112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915007113 Probable transposase; Region: OrfB_IS605; pfam01385 491915007114 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915007115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915007116 AAA domain; Region: AAA_23; pfam13476 491915007117 Walker A/P-loop; other site 491915007118 ATP binding site [chemical binding]; other site 491915007119 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 491915007120 putative active site [active] 491915007121 putative metal-binding site [ion binding]; other site 491915007122 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 491915007123 Part of AAA domain; Region: AAA_19; pfam13245 491915007124 Family description; Region: UvrD_C_2; pfam13538 491915007125 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 491915007126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915007127 S-adenosylmethionine binding site [chemical binding]; other site 491915007128 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 491915007129 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 491915007130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915007131 non-specific DNA binding site [nucleotide binding]; other site 491915007132 salt bridge; other site 491915007133 sequence-specific DNA binding site [nucleotide binding]; other site 491915007134 isocitrate lyase; Provisional; Region: PRK15063 491915007135 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 491915007136 tetramer interface [polypeptide binding]; other site 491915007137 active site 491915007138 Mg2+/Mn2+ binding site [ion binding]; other site 491915007139 Peptidase family M48; Region: Peptidase_M48; pfam01435 491915007140 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 491915007141 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 491915007142 Cu(I) binding site [ion binding]; other site 491915007143 Cache domain; Region: Cache_1; pfam02743 491915007144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915007145 dimerization interface [polypeptide binding]; other site 491915007146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915007147 dimer interface [polypeptide binding]; other site 491915007148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915007149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915007150 dimer interface [polypeptide binding]; other site 491915007151 putative CheW interface [polypeptide binding]; other site 491915007152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915007153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915007154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915007155 non-specific DNA binding site [nucleotide binding]; other site 491915007156 salt bridge; other site 491915007157 sequence-specific DNA binding site [nucleotide binding]; other site 491915007158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915007159 Zn2+ binding site [ion binding]; other site 491915007160 Mg2+ binding site [ion binding]; other site 491915007161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915007162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915007163 DNA binding residues [nucleotide binding] 491915007164 dimerization interface [polypeptide binding]; other site 491915007165 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 491915007166 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915007167 PAS domain; Region: PAS_9; pfam13426 491915007168 PAS domain S-box; Region: sensory_box; TIGR00229 491915007169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 491915007170 putative active site [active] 491915007171 heme pocket [chemical binding]; other site 491915007172 PAS domain; Region: PAS_8; pfam13188 491915007173 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 491915007174 metal binding site [ion binding]; metal-binding site 491915007175 active site 491915007176 I-site; other site 491915007177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 491915007178 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 491915007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915007180 Walker A/P-loop; other site 491915007181 ATP binding site [chemical binding]; other site 491915007182 Q-loop/lid; other site 491915007183 ABC transporter signature motif; other site 491915007184 Walker B; other site 491915007185 D-loop; other site 491915007186 H-loop/switch region; other site 491915007187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915007188 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 491915007189 TM-ABC transporter signature motif; other site 491915007190 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 491915007191 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 491915007192 zinc binding site [ion binding]; other site 491915007193 putative ligand binding site [chemical binding]; other site 491915007194 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 491915007195 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 491915007196 acyl-activating enzyme (AAE) consensus motif; other site 491915007197 putative AMP binding site [chemical binding]; other site 491915007198 putative active site [active] 491915007199 putative CoA binding site [chemical binding]; other site 491915007200 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 491915007201 Probable transposase; Region: OrfB_IS605; pfam01385 491915007202 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915007203 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915007204 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 491915007205 RHS Repeat; Region: RHS_repeat; cl11982 491915007206 RHS Repeat; Region: RHS_repeat; cl11982 491915007207 RHS protein; Region: RHS; pfam03527 491915007208 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007209 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 491915007210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 491915007211 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 491915007212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 491915007213 active site 491915007214 substrate binding site [chemical binding]; other site 491915007215 catalytic site [active] 491915007216 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 491915007217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 491915007218 ligand binding site [chemical binding]; other site 491915007219 flexible hinge region; other site 491915007220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 491915007221 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 491915007222 metal binding triad; other site 491915007223 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 491915007224 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 491915007225 Na binding site [ion binding]; other site 491915007226 Predicted membrane protein [Function unknown]; Region: COG4327 491915007227 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915007228 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915007229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915007230 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915007231 Probable transposase; Region: OrfB_IS605; pfam01385 491915007232 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 491915007233 YhfH-like protein; Region: YhfH; pfam14149 491915007234 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 491915007235 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 491915007236 Ca binding site [ion binding]; other site 491915007237 active site 491915007238 catalytic site [active] 491915007239 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 491915007240 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 491915007241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007242 dimer interface [polypeptide binding]; other site 491915007243 conserved gate region; other site 491915007244 putative PBP binding loops; other site 491915007245 ABC-ATPase subunit interface; other site 491915007246 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 491915007247 SF-assemblin/beta giardin; Region: SF-assemblin; pfam06705 491915007248 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 491915007249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007250 dimer interface [polypeptide binding]; other site 491915007251 conserved gate region; other site 491915007252 putative PBP binding loops; other site 491915007253 ABC-ATPase subunit interface; other site 491915007254 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 491915007255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 491915007256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 491915007257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 491915007258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915007259 DNA binding site [nucleotide binding] 491915007260 domain linker motif; other site 491915007261 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 491915007262 putative ligand binding site [chemical binding]; other site 491915007263 putative dimerization interface [polypeptide binding]; other site 491915007264 Predicted membrane protein [Function unknown]; Region: COG1511 491915007265 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 491915007266 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 491915007267 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 491915007268 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 491915007269 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 491915007270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915007271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915007272 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 491915007273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 491915007274 ferrochelatase; Provisional; Region: PRK12435 491915007275 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 491915007276 C-terminal domain interface [polypeptide binding]; other site 491915007277 active site 491915007278 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 491915007279 active site 491915007280 N-terminal domain interface [polypeptide binding]; other site 491915007281 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 491915007282 substrate binding site [chemical binding]; other site 491915007283 active site 491915007284 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 491915007285 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915007286 active site residue [active] 491915007287 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 491915007288 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 491915007289 metal binding site [ion binding]; metal-binding site 491915007290 dimer interface [polypeptide binding]; other site 491915007291 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 491915007292 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 491915007293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915007294 Walker A/P-loop; other site 491915007295 ATP binding site [chemical binding]; other site 491915007296 Q-loop/lid; other site 491915007297 ABC transporter signature motif; other site 491915007298 Walker B; other site 491915007299 D-loop; other site 491915007300 H-loop/switch region; other site 491915007301 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 491915007302 HIT family signature motif; other site 491915007303 catalytic residue [active] 491915007304 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 491915007305 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 491915007306 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 491915007307 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 491915007308 transcriptional regulator Hpr; Provisional; Region: PRK13777 491915007309 MarR family; Region: MarR; pfam01047 491915007310 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 491915007311 homodimer interface [polypeptide binding]; other site 491915007312 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 491915007313 substrate-cofactor binding pocket; other site 491915007314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915007315 catalytic residue [active] 491915007316 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 491915007317 YhzD-like protein; Region: YhzD; pfam14120 491915007318 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 491915007319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915007320 FeS/SAM binding site; other site 491915007321 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 491915007322 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 491915007323 Protein of unknown function (DUF964); Region: DUF964; cl01483 491915007324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 491915007325 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 491915007326 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 491915007327 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 491915007328 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 491915007329 Walker A/P-loop; other site 491915007330 ATP binding site [chemical binding]; other site 491915007331 Q-loop/lid; other site 491915007332 ABC transporter signature motif; other site 491915007333 Walker B; other site 491915007334 D-loop; other site 491915007335 H-loop/switch region; other site 491915007336 TOBE domain; Region: TOBE; pfam03459 491915007337 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 491915007338 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 491915007339 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 491915007340 Walker A/P-loop; other site 491915007341 ATP binding site [chemical binding]; other site 491915007342 Q-loop/lid; other site 491915007343 ABC transporter signature motif; other site 491915007344 Walker B; other site 491915007345 D-loop; other site 491915007346 H-loop/switch region; other site 491915007347 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 491915007348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007349 dimer interface [polypeptide binding]; other site 491915007350 conserved gate region; other site 491915007351 putative PBP binding loops; other site 491915007352 ABC-ATPase subunit interface; other site 491915007353 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 491915007354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 491915007355 substrate binding pocket [chemical binding]; other site 491915007356 membrane-bound complex binding site; other site 491915007357 hinge residues; other site 491915007358 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 491915007359 Domain of unknown function DUF21; Region: DUF21; pfam01595 491915007360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 491915007361 Transporter associated domain; Region: CorC_HlyC; smart01091 491915007362 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 491915007363 dimer interface [polypeptide binding]; other site 491915007364 substrate binding site [chemical binding]; other site 491915007365 ATP binding site [chemical binding]; other site 491915007366 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 491915007367 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 491915007368 ATP binding site [chemical binding]; other site 491915007369 substrate interface [chemical binding]; other site 491915007370 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 491915007371 ThiS interaction site; other site 491915007372 putative active site [active] 491915007373 tetramer interface [polypeptide binding]; other site 491915007374 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 491915007375 thiS-thiF/thiG interaction site; other site 491915007376 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 491915007377 hydroxyglutarate oxidase; Provisional; Region: PRK11728 491915007378 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 491915007379 thiamine phosphate binding site [chemical binding]; other site 491915007380 active site 491915007381 pyrophosphate binding site [ion binding]; other site 491915007382 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 491915007383 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 491915007384 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915007385 Walker A/P-loop; other site 491915007386 ATP binding site [chemical binding]; other site 491915007387 Q-loop/lid; other site 491915007388 ABC transporter signature motif; other site 491915007389 Walker B; other site 491915007390 D-loop; other site 491915007391 H-loop/switch region; other site 491915007392 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 491915007393 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 491915007394 Walker A/P-loop; other site 491915007395 ATP binding site [chemical binding]; other site 491915007396 Q-loop/lid; other site 491915007397 ABC transporter signature motif; other site 491915007398 Walker B; other site 491915007399 D-loop; other site 491915007400 H-loop/switch region; other site 491915007401 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 491915007402 Putative transcription activator [Transcription]; Region: TenA; COG0819 491915007403 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 491915007404 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 491915007405 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 491915007406 putative RNA binding site [nucleotide binding]; other site 491915007407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915007408 S-adenosylmethionine binding site [chemical binding]; other site 491915007409 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 491915007410 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 491915007411 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 491915007412 Ca binding site [ion binding]; other site 491915007413 active site 491915007414 catalytic site [active] 491915007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915007416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 491915007417 putative substrate translocation pore; other site 491915007418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915007419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 491915007420 MarR family; Region: MarR; pfam01047 491915007421 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 491915007422 SpoVR like protein; Region: SpoVR; pfam04293 491915007423 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 491915007424 HflK protein; Region: hflK; TIGR01933 491915007425 HflC protein; Region: hflC; TIGR01932 491915007426 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 491915007427 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 491915007428 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 491915007429 DNA binding site [nucleotide binding] 491915007430 active site 491915007431 YhdB-like protein; Region: YhdB; pfam14148 491915007432 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 491915007433 classical (c) SDRs; Region: SDR_c; cd05233 491915007434 NAD(P) binding site [chemical binding]; other site 491915007435 active site 491915007436 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 491915007437 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 491915007438 active site 491915007439 substrate binding site [chemical binding]; other site 491915007440 metal binding site [ion binding]; metal-binding site 491915007441 FOG: CBS domain [General function prediction only]; Region: COG0517 491915007442 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 491915007443 putative disulfide oxidoreductase; Provisional; Region: PRK03113 491915007444 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 491915007445 catalytic residues [active] 491915007446 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 491915007447 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 491915007448 active site 491915007449 Transposase domain (DUF772); Region: DUF772; pfam05598 491915007450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915007451 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915007452 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 491915007453 Domain of unknown function DUF21; Region: DUF21; pfam01595 491915007454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 491915007455 Transporter associated domain; Region: CorC_HlyC; smart01091 491915007456 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 491915007457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 491915007458 active site residue [active] 491915007459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 491915007460 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 491915007461 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 491915007462 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 491915007463 CPxP motif; other site 491915007464 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 491915007465 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 491915007466 CPxP motif; other site 491915007467 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915007468 active site residue [active] 491915007469 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 491915007470 active site residue [active] 491915007471 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 491915007472 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 491915007473 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 491915007474 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 491915007475 Putative amidase domain; Region: Amidase_6; pfam12671 491915007476 epoxyqueuosine reductase; Region: TIGR00276 491915007477 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 491915007478 HEAT repeats; Region: HEAT_2; pfam13646 491915007479 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 491915007480 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 491915007481 B3/4 domain; Region: B3_4; pfam03483 491915007482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 491915007483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915007484 DNA binding site [nucleotide binding] 491915007485 domain linker motif; other site 491915007486 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 491915007487 dimerization interface [polypeptide binding]; other site 491915007488 ligand binding site [chemical binding]; other site 491915007489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 491915007490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007491 dimer interface [polypeptide binding]; other site 491915007492 conserved gate region; other site 491915007493 putative PBP binding loops; other site 491915007494 ABC-ATPase subunit interface; other site 491915007495 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 491915007496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007497 dimer interface [polypeptide binding]; other site 491915007498 conserved gate region; other site 491915007499 putative PBP binding loops; other site 491915007500 ABC-ATPase subunit interface; other site 491915007501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 491915007502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 491915007503 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 491915007504 beta-galactosidase; Region: BGL; TIGR03356 491915007505 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 491915007506 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 491915007507 EamA-like transporter family; Region: EamA; cl17759 491915007508 EamA-like transporter family; Region: EamA; pfam00892 491915007509 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 491915007510 MgtC family; Region: MgtC; pfam02308 491915007511 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 491915007512 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915007513 Zn2+ binding site [ion binding]; other site 491915007514 Mg2+ binding site [ion binding]; other site 491915007515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915007516 dimerization interface [polypeptide binding]; other site 491915007517 putative DNA binding site [nucleotide binding]; other site 491915007518 putative Zn2+ binding site [ion binding]; other site 491915007519 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 491915007520 Domain of unknown function DUF21; Region: DUF21; pfam01595 491915007521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 491915007522 Transporter associated domain; Region: CorC_HlyC; smart01091 491915007523 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 491915007524 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 491915007525 DNA binding residues [nucleotide binding] 491915007526 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 491915007527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 491915007528 Transposase; Region: DDE_Tnp_ISL3; pfam01610 491915007529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 491915007530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915007531 Walker A/P-loop; other site 491915007532 ATP binding site [chemical binding]; other site 491915007533 Q-loop/lid; other site 491915007534 ABC transporter signature motif; other site 491915007535 Walker B; other site 491915007536 D-loop; other site 491915007537 H-loop/switch region; other site 491915007538 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915007539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915007540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 491915007541 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 491915007542 Winged helix-turn helix; Region: HTH_33; pfam13592 491915007543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915007544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915007545 sequence-specific DNA binding site [nucleotide binding]; other site 491915007546 salt bridge; other site 491915007547 Winged helix-turn helix; Region: HTH_29; pfam13551 491915007548 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915007549 Winged helix-turn helix; Region: HTH_33; pfam13592 491915007550 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915007551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915007552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915007553 putative transposase OrfB; Reviewed; Region: PHA02517 491915007554 HTH-like domain; Region: HTH_21; pfam13276 491915007555 Integrase core domain; Region: rve; pfam00665 491915007556 Integrase core domain; Region: rve_3; pfam13683 491915007557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915007558 Transposase; Region: HTH_Tnp_1; pfam01527 491915007559 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915007560 Small acid-soluble spore protein H family; Region: SspH; pfam08141 491915007561 Ion channel; Region: Ion_trans_2; pfam07885 491915007562 Ion transport protein; Region: Ion_trans; pfam00520 491915007563 TrkA-N domain; Region: TrkA_N; pfam02254 491915007564 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 491915007565 YugN-like family; Region: YugN; pfam08868 491915007566 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 491915007567 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 491915007568 active site 491915007569 dimer interface [polypeptide binding]; other site 491915007570 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 491915007571 dimer interface [polypeptide binding]; other site 491915007572 active site 491915007573 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 491915007574 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 491915007575 dimer interface [polypeptide binding]; other site 491915007576 active site 491915007577 metal binding site [ion binding]; metal-binding site 491915007578 Domain of unknown function (DUF378); Region: DUF378; pfam04070 491915007579 general stress protein 13; Validated; Region: PRK08059 491915007580 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 491915007581 RNA binding site [nucleotide binding]; other site 491915007582 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 491915007583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915007584 non-specific DNA binding site [nucleotide binding]; other site 491915007585 salt bridge; other site 491915007586 sequence-specific DNA binding site [nucleotide binding]; other site 491915007587 hypothetical protein; Validated; Region: PRK07682 491915007588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 491915007589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915007590 homodimer interface [polypeptide binding]; other site 491915007591 catalytic residue [active] 491915007592 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 491915007593 AsnC family; Region: AsnC_trans_reg; pfam01037 491915007594 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 491915007595 E-class dimer interface [polypeptide binding]; other site 491915007596 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 491915007597 P-class dimer interface [polypeptide binding]; other site 491915007598 active site 491915007599 Cu2+ binding site [ion binding]; other site 491915007600 Zn2+ binding site [ion binding]; other site 491915007601 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 491915007602 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 491915007603 transmembrane helices; other site 491915007604 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 491915007605 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 491915007606 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 491915007607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 491915007608 Putative membrane protein; Region: YuiB; pfam14068 491915007609 chaperone protein DnaJ; Provisional; Region: PRK14280 491915007610 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 491915007611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915007612 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 491915007613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915007614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915007615 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 491915007616 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 491915007617 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 491915007618 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 491915007619 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 491915007620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 491915007621 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 491915007622 hypothetical protein; Provisional; Region: PRK13669 491915007623 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 491915007624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915007625 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 491915007626 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 491915007627 homoserine kinase; Provisional; Region: PRK01212 491915007628 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 491915007629 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 491915007630 threonine synthase; Reviewed; Region: PRK06721 491915007631 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 491915007632 homodimer interface [polypeptide binding]; other site 491915007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915007634 catalytic residue [active] 491915007635 homoserine dehydrogenase; Provisional; Region: PRK06349 491915007636 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 491915007637 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 491915007638 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 491915007639 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 491915007640 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 491915007641 dimerization interface [polypeptide binding]; other site 491915007642 ligand binding site [chemical binding]; other site 491915007643 NADP binding site [chemical binding]; other site 491915007644 catalytic site [active] 491915007645 spore coat protein YutH; Region: spore_yutH; TIGR02905 491915007646 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 491915007647 tetramer interfaces [polypeptide binding]; other site 491915007648 binuclear metal-binding site [ion binding]; other site 491915007649 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 491915007650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915007651 active site 491915007652 motif I; other site 491915007653 motif II; other site 491915007654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915007655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 491915007656 Predicted transcriptional regulator [Transcription]; Region: COG2345 491915007657 putative DNA binding site [nucleotide binding]; other site 491915007658 putative Zn2+ binding site [ion binding]; other site 491915007659 Uncharacterized conserved protein [Function unknown]; Region: COG2445 491915007660 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 491915007661 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 491915007662 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 491915007663 lipoyl synthase; Provisional; Region: PRK05481 491915007664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915007665 FeS/SAM binding site; other site 491915007666 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 491915007667 Peptidase family M23; Region: Peptidase_M23; pfam01551 491915007668 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 491915007669 Na2 binding site [ion binding]; other site 491915007670 putative substrate binding site 1 [chemical binding]; other site 491915007671 Na binding site 1 [ion binding]; other site 491915007672 putative substrate binding site 2 [chemical binding]; other site 491915007673 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 491915007674 Uncharacterized conserved protein [Function unknown]; Region: COG3377 491915007675 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 491915007676 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 491915007677 active site 491915007678 metal binding site [ion binding]; metal-binding site 491915007679 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 491915007680 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 491915007681 Protein of unknown function DUF72; Region: DUF72; pfam01904 491915007682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915007683 Transposase; Region: HTH_Tnp_1; pfam01527 491915007684 putative transposase OrfB; Reviewed; Region: PHA02517 491915007685 HTH-like domain; Region: HTH_21; pfam13276 491915007686 Integrase core domain; Region: rve; pfam00665 491915007687 Integrase core domain; Region: rve_3; pfam13683 491915007688 Domain of unknown function (DUF955); Region: DUF955; pfam06114 491915007689 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 491915007690 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 491915007691 active site 491915007692 DNA binding site [nucleotide binding] 491915007693 Int/Topo IB signature motif; other site 491915007694 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 491915007695 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 491915007696 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 491915007697 B12 binding domain; Region: B12-binding; pfam02310 491915007698 B12 binding site [chemical binding]; other site 491915007699 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 491915007700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915007701 FeS/SAM binding site; other site 491915007702 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 491915007703 Zn binding site [ion binding]; other site 491915007704 H+ Antiporter protein; Region: 2A0121; TIGR00900 491915007705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915007706 putative substrate translocation pore; other site 491915007707 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 491915007708 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 491915007709 active site 491915007710 HIGH motif; other site 491915007711 dimer interface [polypeptide binding]; other site 491915007712 KMSKS motif; other site 491915007713 Transposase, Mutator family; Region: Transposase_mut; pfam00872 491915007714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915007715 Transposase; Region: HTH_Tnp_1; pfam01527 491915007716 putative transposase OrfB; Reviewed; Region: PHA02517 491915007717 HTH-like domain; Region: HTH_21; pfam13276 491915007718 Integrase core domain; Region: rve; pfam00665 491915007719 Integrase core domain; Region: rve_3; pfam13683 491915007720 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 491915007721 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 491915007722 putative active site [active] 491915007723 putative NTP binding site [chemical binding]; other site 491915007724 putative nucleic acid binding site [nucleotide binding]; other site 491915007725 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 491915007726 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 491915007727 Winged helix-turn helix; Region: HTH_29; pfam13551 491915007728 Homeodomain-like domain; Region: HTH_32; pfam13565 491915007729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 491915007730 Integrase core domain; Region: rve; pfam00665 491915007731 Integrase core domain; Region: rve_3; pfam13683 491915007732 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 491915007733 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 491915007734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915007735 Walker A motif; other site 491915007736 ATP binding site [chemical binding]; other site 491915007737 Walker B motif; other site 491915007738 arginine finger; other site 491915007739 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915007740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915007741 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915007742 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915007743 DDE superfamily endonuclease; Region: DDE_3; pfam13358 491915007744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 491915007745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 491915007746 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 491915007747 Winged helix-turn helix; Region: HTH_33; pfam13592 491915007748 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 491915007749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 491915007750 DNA binding site [nucleotide binding] 491915007751 active site 491915007752 Int/Topo IB signature motif; other site 491915007753 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 491915007754 FeS assembly protein SufB; Region: sufB; TIGR01980 491915007755 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 491915007756 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 491915007757 trimerization site [polypeptide binding]; other site 491915007758 active site 491915007759 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 491915007760 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 491915007761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 491915007762 catalytic residue [active] 491915007763 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 491915007764 FeS assembly protein SufD; Region: sufD; TIGR01981 491915007765 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 491915007766 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 491915007767 Walker A/P-loop; other site 491915007768 ATP binding site [chemical binding]; other site 491915007769 Q-loop/lid; other site 491915007770 ABC transporter signature motif; other site 491915007771 Walker B; other site 491915007772 D-loop; other site 491915007773 H-loop/switch region; other site 491915007774 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 491915007775 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 491915007776 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 491915007777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915007778 ABC-ATPase subunit interface; other site 491915007779 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 491915007780 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 491915007781 Walker A/P-loop; other site 491915007782 ATP binding site [chemical binding]; other site 491915007783 Q-loop/lid; other site 491915007784 ABC transporter signature motif; other site 491915007785 Walker B; other site 491915007786 D-loop; other site 491915007787 H-loop/switch region; other site 491915007788 NIL domain; Region: NIL; pfam09383 491915007789 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 491915007790 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915007791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915007792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915007793 active site 491915007794 phosphorylation site [posttranslational modification] 491915007795 intermolecular recognition site; other site 491915007796 dimerization interface [polypeptide binding]; other site 491915007797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915007798 DNA binding residues [nucleotide binding] 491915007799 dimerization interface [polypeptide binding]; other site 491915007800 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 491915007801 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 491915007802 homodimer interface [polypeptide binding]; other site 491915007803 substrate-cofactor binding pocket; other site 491915007804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 491915007805 catalytic residue [active] 491915007806 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 491915007807 catalytic residues [active] 491915007808 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 491915007809 active site 491915007810 metal binding site [ion binding]; metal-binding site 491915007811 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 491915007812 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 491915007813 lipoyl attachment site [posttranslational modification]; other site 491915007814 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 491915007815 ArsC family; Region: ArsC; pfam03960 491915007816 putative ArsC-like catalytic residues; other site 491915007817 putative TRX-like catalytic residues [active] 491915007818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 491915007819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915007820 active site 491915007821 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 491915007822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 491915007823 dimer interface [polypeptide binding]; other site 491915007824 active site 491915007825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 491915007826 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 491915007827 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 491915007828 YuzL-like protein; Region: YuzL; pfam14115 491915007829 Proline dehydrogenase; Region: Pro_dh; cl03282 491915007830 Coat F domain; Region: Coat_F; pfam07875 491915007831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915007832 Zn2+ binding site [ion binding]; other site 491915007833 Mg2+ binding site [ion binding]; other site 491915007834 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 491915007835 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 491915007836 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 491915007837 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 491915007838 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 491915007839 Walker A/P-loop; other site 491915007840 ATP binding site [chemical binding]; other site 491915007841 Q-loop/lid; other site 491915007842 ABC transporter signature motif; other site 491915007843 Walker B; other site 491915007844 D-loop; other site 491915007845 H-loop/switch region; other site 491915007846 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 491915007847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 491915007848 ABC-ATPase subunit interface; other site 491915007849 dimer interface [polypeptide binding]; other site 491915007850 putative PBP binding regions; other site 491915007851 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 491915007852 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 491915007853 intersubunit interface [polypeptide binding]; other site 491915007854 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 491915007855 SmpB-tmRNA interface; other site 491915007856 ribonuclease R; Region: RNase_R; TIGR02063 491915007857 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 491915007858 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 491915007859 RNB domain; Region: RNB; pfam00773 491915007860 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 491915007861 RNA binding site [nucleotide binding]; other site 491915007862 Esterase/lipase [General function prediction only]; Region: COG1647 491915007863 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 491915007864 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 491915007865 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 491915007866 RHS protein; Region: RHS; pfam03527 491915007867 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007868 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 491915007869 RHS Repeat; Region: RHS_repeat; cl11982 491915007870 RHS protein; Region: RHS; pfam03527 491915007871 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007872 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 491915007873 RHS Repeat; Region: RHS_repeat; cl11982 491915007874 RHS protein; Region: RHS; pfam03527 491915007875 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007876 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007877 YxiJ-like protein; Region: YxiJ; pfam14176 491915007878 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 491915007879 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 491915007880 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 491915007881 RHS Repeat; Region: RHS_repeat; pfam05593 491915007882 RHS Repeat; Region: RHS_repeat; cl11982 491915007883 RHS protein; Region: RHS; pfam03527 491915007884 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 491915007885 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 491915007886 enolase; Provisional; Region: eno; PRK00077 491915007887 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 491915007888 dimer interface [polypeptide binding]; other site 491915007889 metal binding site [ion binding]; metal-binding site 491915007890 substrate binding pocket [chemical binding]; other site 491915007891 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 491915007892 phosphoglyceromutase; Provisional; Region: PRK05434 491915007893 triosephosphate isomerase; Provisional; Region: PRK14567 491915007894 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 491915007895 substrate binding site [chemical binding]; other site 491915007896 dimer interface [polypeptide binding]; other site 491915007897 catalytic triad [active] 491915007898 Phosphoglycerate kinase; Region: PGK; pfam00162 491915007899 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 491915007900 substrate binding site [chemical binding]; other site 491915007901 hinge regions; other site 491915007902 ADP binding site [chemical binding]; other site 491915007903 catalytic site [active] 491915007904 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 491915007905 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 491915007906 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 491915007907 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 491915007908 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 491915007909 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 491915007910 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 491915007911 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 491915007912 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 491915007913 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 491915007914 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 491915007915 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 491915007916 oligomer interface [polypeptide binding]; other site 491915007917 active site residues [active] 491915007918 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 491915007919 dimerization domain swap beta strand [polypeptide binding]; other site 491915007920 regulatory protein interface [polypeptide binding]; other site 491915007921 active site 491915007922 regulatory phosphorylation site [posttranslational modification]; other site 491915007923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 491915007924 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 491915007925 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 491915007926 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 491915007927 phosphate binding site [ion binding]; other site 491915007928 putative substrate binding pocket [chemical binding]; other site 491915007929 dimer interface [polypeptide binding]; other site 491915007930 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 491915007931 AAA domain; Region: AAA_33; pfam13671 491915007932 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 491915007933 putative active site [active] 491915007934 nucleotide binding site [chemical binding]; other site 491915007935 nudix motif; other site 491915007936 putative metal binding site [ion binding]; other site 491915007937 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 491915007938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915007939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915007940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915007941 binding surface 491915007942 TPR motif; other site 491915007943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 491915007944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915007945 binding surface 491915007946 TPR motif; other site 491915007947 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 491915007948 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 491915007949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 491915007950 metal binding site [ion binding]; metal-binding site 491915007951 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 491915007952 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 491915007953 substrate binding site [chemical binding]; other site 491915007954 glutamase interaction surface [polypeptide binding]; other site 491915007955 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 491915007956 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 491915007957 catalytic residues [active] 491915007958 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 491915007959 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 491915007960 putative active site [active] 491915007961 oxyanion strand; other site 491915007962 catalytic triad [active] 491915007963 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 491915007964 putative active site pocket [active] 491915007965 4-fold oligomerization interface [polypeptide binding]; other site 491915007966 metal binding residues [ion binding]; metal-binding site 491915007967 3-fold/trimer interface [polypeptide binding]; other site 491915007968 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 491915007969 histidinol dehydrogenase; Region: hisD; TIGR00069 491915007970 NAD binding site [chemical binding]; other site 491915007971 dimerization interface [polypeptide binding]; other site 491915007972 product binding site; other site 491915007973 substrate binding site [chemical binding]; other site 491915007974 zinc binding site [ion binding]; other site 491915007975 catalytic residues [active] 491915007976 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 491915007977 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 491915007978 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 491915007979 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 491915007980 dimer interface [polypeptide binding]; other site 491915007981 motif 1; other site 491915007982 active site 491915007983 motif 2; other site 491915007984 motif 3; other site 491915007985 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 491915007986 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 491915007987 trimer interface [polypeptide binding]; other site 491915007988 active site 491915007989 substrate binding site [chemical binding]; other site 491915007990 CoA binding site [chemical binding]; other site 491915007991 pyrophosphatase PpaX; Provisional; Region: PRK13288 491915007992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915007993 active site 491915007994 motif I; other site 491915007995 motif II; other site 491915007996 Nucleoside recognition; Region: Gate; pfam07670 491915007997 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 491915007998 HPr kinase/phosphorylase; Provisional; Region: PRK05428 491915007999 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 491915008000 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 491915008001 Hpr binding site; other site 491915008002 active site 491915008003 homohexamer subunit interaction site [polypeptide binding]; other site 491915008004 Membrane protein of unknown function; Region: DUF360; cl00850 491915008005 PspC domain; Region: PspC; pfam04024 491915008006 Tic20-like protein; Region: Tic20; pfam09685 491915008007 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 491915008008 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 491915008009 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 491915008010 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 491915008011 excinuclease ABC subunit B; Provisional; Region: PRK05298 491915008012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915008013 ATP binding site [chemical binding]; other site 491915008014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915008015 nucleotide binding region [chemical binding]; other site 491915008016 ATP-binding site [chemical binding]; other site 491915008017 Ultra-violet resistance protein B; Region: UvrB; pfam12344 491915008018 UvrB/uvrC motif; Region: UVR; pfam02151 491915008019 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 491915008020 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 491915008021 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 491915008022 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 491915008023 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 491915008024 DNA binding residues [nucleotide binding] 491915008025 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 491915008026 C-terminal peptidase (prc); Region: prc; TIGR00225 491915008027 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 491915008028 protein binding site [polypeptide binding]; other site 491915008029 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 491915008030 Catalytic dyad [active] 491915008031 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 491915008032 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 491915008033 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 491915008034 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 491915008035 Divergent AAA domain; Region: AAA_4; pfam04326 491915008036 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 491915008037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 491915008038 Tho complex subunit 7; Region: THOC7; pfam05615 491915008039 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 491915008040 Peptidase family M23; Region: Peptidase_M23; pfam01551 491915008041 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 491915008042 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 491915008043 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 491915008044 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 491915008045 Walker A/P-loop; other site 491915008046 ATP binding site [chemical binding]; other site 491915008047 Q-loop/lid; other site 491915008048 ABC transporter signature motif; other site 491915008049 Walker B; other site 491915008050 D-loop; other site 491915008051 H-loop/switch region; other site 491915008052 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 491915008053 Uncharacterized conserved protein [Function unknown]; Region: COG1284 491915008054 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915008055 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 491915008056 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 491915008057 peptide chain release factor 2; Provisional; Region: PRK06746 491915008058 This domain is found in peptide chain release factors; Region: PCRF; smart00937 491915008059 RF-1 domain; Region: RF-1; pfam00472 491915008060 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 491915008061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 491915008062 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 491915008063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915008064 nucleotide binding region [chemical binding]; other site 491915008065 ATP-binding site [chemical binding]; other site 491915008066 SEC-C motif; Region: SEC-C; pfam02810 491915008067 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 491915008068 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 491915008069 30S subunit binding site; other site 491915008070 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 491915008071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915008072 Zn2+ binding site [ion binding]; other site 491915008073 Mg2+ binding site [ion binding]; other site 491915008074 flagellar protein FliS; Validated; Region: fliS; PRK05685 491915008075 flagellar capping protein; Validated; Region: fliD; PRK07737 491915008076 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 491915008077 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 491915008078 flagellar protein FlaG; Provisional; Region: PRK07738 491915008079 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 491915008080 putative metal binding site; other site 491915008081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 491915008082 TPR motif; other site 491915008083 binding surface 491915008084 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 491915008085 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 491915008086 active site 491915008087 nucleotide binding site [chemical binding]; other site 491915008088 HIGH motif; other site 491915008089 KMSKS motif; other site 491915008090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 491915008091 active site 491915008092 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 491915008093 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 491915008094 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 491915008095 putative metal binding site; other site 491915008096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915008097 binding surface 491915008098 TPR motif; other site 491915008099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 491915008100 binding surface 491915008101 TPR motif; other site 491915008102 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 491915008103 authentic frameshift 491915008104 carbon storage regulator; Provisional; Region: PRK01712 491915008105 flagellar assembly protein FliW; Provisional; Region: PRK13285 491915008106 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 491915008107 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 491915008108 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 491915008109 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 491915008110 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915008111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 491915008112 FlgN protein; Region: FlgN; pfam05130 491915008113 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 491915008114 flagellar operon protein TIGR03826; Region: YvyF 491915008115 Protein of unknown function (DUF327); Region: DUF327; pfam03885 491915008116 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 491915008117 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 491915008118 Flagellar protein FliS; Region: FliS; cl00654 491915008119 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 491915008120 MAEBL; Provisional; Region: PTZ00121 491915008121 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 491915008122 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 491915008123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915008124 active site 491915008125 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 491915008126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915008127 ATP binding site [chemical binding]; other site 491915008128 putative Mg++ binding site [ion binding]; other site 491915008129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915008130 nucleotide binding region [chemical binding]; other site 491915008131 ATP-binding site [chemical binding]; other site 491915008132 EDD domain protein, DegV family; Region: DegV; TIGR00762 491915008133 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 491915008134 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915008135 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 491915008136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915008137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915008138 active site 491915008139 phosphorylation site [posttranslational modification] 491915008140 intermolecular recognition site; other site 491915008141 dimerization interface [polypeptide binding]; other site 491915008142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915008143 DNA binding residues [nucleotide binding] 491915008144 dimerization interface [polypeptide binding]; other site 491915008145 Sensor protein DegS; Region: DegS; pfam05384 491915008146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 491915008147 Histidine kinase; Region: HisKA_3; pfam07730 491915008148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915008149 ATP binding site [chemical binding]; other site 491915008150 Mg2+ binding site [ion binding]; other site 491915008151 G-X-G motif; other site 491915008152 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 491915008153 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 491915008154 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 491915008155 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 491915008156 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 491915008157 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 491915008158 Mg++ binding site [ion binding]; other site 491915008159 putative catalytic motif [active] 491915008160 substrate binding site [chemical binding]; other site 491915008161 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 491915008162 Stage II sporulation protein; Region: SpoIID; pfam08486 491915008163 S-layer homology domain; Region: SLH; pfam00395 491915008164 S-layer homology domain; Region: SLH; pfam00395 491915008165 S-layer homology domain; Region: SLH; pfam00395 491915008166 S-layer homology domain; Region: SLH; pfam00395 491915008167 S-layer homology domain; Region: SLH; pfam00395 491915008168 S-layer homology domain; Region: SLH; pfam00395 491915008169 Bacterial SH3 domain; Region: SH3_3; pfam08239 491915008170 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 491915008171 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 491915008172 active site 491915008173 metal binding site [ion binding]; metal-binding site 491915008174 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 491915008175 active site 491915008176 catalytic residues [active] 491915008177 S-layer homology domain; Region: SLH; pfam00395 491915008178 S-layer homology domain; Region: SLH; pfam00395 491915008179 S-layer homology domain; Region: SLH; pfam00395 491915008180 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 491915008181 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 491915008182 active site 491915008183 metal binding site [ion binding]; metal-binding site 491915008184 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 491915008185 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 491915008186 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 491915008187 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 491915008188 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 491915008189 glycogen binding site [chemical binding]; other site 491915008190 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 491915008191 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 491915008192 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 491915008193 homodimer interface [polypeptide binding]; other site 491915008194 maltodextrin glucosidase; Provisional; Region: PRK10785 491915008195 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 491915008196 active site 491915008197 homodimer interface [polypeptide binding]; other site 491915008198 catalytic site [active] 491915008199 Aamy_C domain; Region: Aamy_C; smart00632 491915008200 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 491915008201 Interdomain contacts; other site 491915008202 Starch binding domain; Region: CBM_2; smart01065 491915008203 S-layer homology domain; Region: SLH; pfam00395 491915008204 S-layer homology domain; Region: SLH; pfam00395 491915008205 S-layer homology domain; Region: SLH; pfam00395 491915008206 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 491915008207 CAAX protease self-immunity; Region: Abi; pfam02517 491915008208 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 491915008209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 491915008210 HlyD family secretion protein; Region: HlyD_3; pfam13437 491915008211 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 491915008212 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 491915008213 putative active site [active] 491915008214 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 491915008215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915008216 Walker A/P-loop; other site 491915008217 ATP binding site [chemical binding]; other site 491915008218 Q-loop/lid; other site 491915008219 ABC transporter signature motif; other site 491915008220 Walker B; other site 491915008221 D-loop; other site 491915008222 H-loop/switch region; other site 491915008223 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 491915008224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 491915008225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915008226 ATP binding site [chemical binding]; other site 491915008227 Mg2+ binding site [ion binding]; other site 491915008228 G-X-G motif; other site 491915008229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915008230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915008231 active site 491915008232 phosphorylation site [posttranslational modification] 491915008233 intermolecular recognition site; other site 491915008234 dimerization interface [polypeptide binding]; other site 491915008235 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915008236 DNA binding residues [nucleotide binding] 491915008237 dimerization interface [polypeptide binding]; other site 491915008238 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 491915008239 putative active site [active] 491915008240 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 491915008241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 491915008242 Helix-turn-helix domain; Region: HTH_28; pfam13518 491915008243 HTH-like domain; Region: HTH_21; pfam13276 491915008244 Integrase core domain; Region: rve; pfam00665 491915008245 Integrase core domain; Region: rve_3; pfam13683 491915008246 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 491915008247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 491915008248 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 491915008249 DNA-binding interface [nucleotide binding]; DNA binding site 491915008250 Integrase core domain; Region: rve; pfam00665 491915008251 transposase/IS protein; Provisional; Region: PRK09183 491915008252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 491915008253 Walker A motif; other site 491915008254 ATP binding site [chemical binding]; other site 491915008255 Walker B motif; other site 491915008256 S-layer homology domain; Region: SLH; pfam00395 491915008257 S-layer homology domain; Region: SLH; pfam00395 491915008258 S-layer homology domain; Region: SLH; pfam00395 491915008259 Bacterial Ig-like domain; Region: Big_5; pfam13205 491915008260 NlpC/P60 family; Region: NLPC_P60; pfam00877 491915008261 S-layer homology domain; Region: SLH; pfam00395 491915008262 S-layer homology domain; Region: SLH; pfam00395 491915008263 S-layer homology domain; Region: SLH; pfam00395 491915008264 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 491915008265 S-layer homology domain; Region: SLH; pfam00395 491915008266 S-layer homology domain; Region: SLH; pfam00395 491915008267 S-layer homology domain; Region: SLH; pfam00395 491915008268 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 491915008269 active site 491915008270 catalytic residues [active] 491915008271 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 491915008272 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 491915008273 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 491915008274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 491915008275 nucleotide binding region [chemical binding]; other site 491915008276 ATP-binding site [chemical binding]; other site 491915008277 transcriptional repressor DicA; Reviewed; Region: PRK09706 491915008278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 491915008279 non-specific DNA binding site [nucleotide binding]; other site 491915008280 salt bridge; other site 491915008281 sequence-specific DNA binding site [nucleotide binding]; other site 491915008282 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 491915008283 YwpF-like protein; Region: YwpF; pfam14183 491915008284 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 491915008285 active site 491915008286 catalytic site [active] 491915008287 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 491915008288 allosteric regulatory residue; other site 491915008289 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 491915008290 aspartate kinase; Reviewed; Region: PRK09034 491915008291 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 491915008292 putative catalytic residues [active] 491915008293 putative nucleotide binding site [chemical binding]; other site 491915008294 putative aspartate binding site [chemical binding]; other site 491915008295 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 491915008296 allosteric regulatory residue; other site 491915008297 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 491915008298 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 491915008299 ComK protein; Region: ComK; cl11560 491915008300 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 491915008301 HAMP domain; Region: HAMP; pfam00672 491915008302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915008303 dimer interface [polypeptide binding]; other site 491915008304 putative CheW interface [polypeptide binding]; other site 491915008305 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 491915008306 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 491915008307 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 491915008308 stage V sporulation protein B; Region: spore_V_B; TIGR02900 491915008309 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 491915008310 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 491915008311 SEC-C motif; Region: SEC-C; pfam02810 491915008312 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 491915008313 S1 domain; Region: S1_2; pfam13509 491915008314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 491915008315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 491915008316 Fic family protein [Function unknown]; Region: COG3177 491915008317 Fic/DOC family; Region: Fic; pfam02661 491915008318 Predicted integral membrane protein [Function unknown]; Region: COG5652 491915008319 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 491915008320 Fic family protein [Function unknown]; Region: COG3177 491915008321 Fic/DOC family; Region: Fic; pfam02661 491915008322 Helix-turn-helix domain; Region: HTH_36; pfam13730 491915008323 Uncharacterized conserved protein [Function unknown]; Region: COG4715 491915008324 SNF2 Helicase protein; Region: DUF3670; pfam12419 491915008325 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 491915008326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 491915008327 ATP binding site [chemical binding]; other site 491915008328 putative Mg++ binding site [ion binding]; other site 491915008329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 491915008330 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 491915008331 nucleotide binding region [chemical binding]; other site 491915008332 ATP-binding site [chemical binding]; other site 491915008333 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 491915008334 Protein export membrane protein; Region: SecD_SecF; cl14618 491915008335 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 491915008336 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 491915008337 NAD binding site [chemical binding]; other site 491915008338 homodimer interface [polypeptide binding]; other site 491915008339 active site 491915008340 substrate binding site [chemical binding]; other site 491915008341 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 491915008342 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 491915008343 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 491915008344 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 491915008345 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 491915008346 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 491915008347 ligand binding site [chemical binding]; other site 491915008348 dimerization interface [polypeptide binding]; other site 491915008349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 491915008350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 491915008351 TM-ABC transporter signature motif; other site 491915008352 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 491915008353 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 491915008354 Walker A/P-loop; other site 491915008355 ATP binding site [chemical binding]; other site 491915008356 Q-loop/lid; other site 491915008357 ABC transporter signature motif; other site 491915008358 Walker B; other site 491915008359 D-loop; other site 491915008360 H-loop/switch region; other site 491915008361 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 491915008362 D-ribose pyranase; Provisional; Region: PRK11797 491915008363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 491915008364 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 491915008365 substrate binding site [chemical binding]; other site 491915008366 dimer interface [polypeptide binding]; other site 491915008367 ATP binding site [chemical binding]; other site 491915008368 Transcriptional regulators [Transcription]; Region: PurR; COG1609 491915008369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 491915008370 DNA binding site [nucleotide binding] 491915008371 domain linker motif; other site 491915008372 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 491915008373 dimerization interface [polypeptide binding]; other site 491915008374 ligand binding site [chemical binding]; other site 491915008375 sodium binding site [ion binding]; other site 491915008376 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 491915008377 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 491915008378 active site 491915008379 tetramer interface; other site 491915008380 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 491915008381 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 491915008382 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 491915008383 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915008384 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 491915008385 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 491915008386 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 491915008387 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 491915008388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915008389 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915008390 Probable transposase; Region: OrfB_IS605; pfam01385 491915008391 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915008392 rod shape-determining protein Mbl; Provisional; Region: PRK13928 491915008393 MreB and similar proteins; Region: MreB_like; cd10225 491915008394 nucleotide binding site [chemical binding]; other site 491915008395 Mg binding site [ion binding]; other site 491915008396 putative protofilament interaction site [polypeptide binding]; other site 491915008397 RodZ interaction site [polypeptide binding]; other site 491915008398 Stage III sporulation protein D; Region: SpoIIID; pfam12116 491915008399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 491915008400 Peptidase family M23; Region: Peptidase_M23; pfam01551 491915008401 Stage II sporulation protein; Region: SpoIID; pfam08486 491915008402 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 491915008403 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 491915008404 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 491915008405 hinge; other site 491915008406 active site 491915008407 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 491915008408 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 491915008409 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 491915008410 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 491915008411 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 491915008412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 491915008413 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 491915008414 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 491915008415 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 491915008416 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 491915008417 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 491915008418 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 491915008419 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 491915008420 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 491915008421 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 491915008422 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 491915008423 NADH dehydrogenase subunit C; Validated; Region: PRK07735 491915008424 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 491915008425 NADH dehydrogenase subunit B; Validated; Region: PRK06411 491915008426 NADH dehydrogenase subunit A; Validated; Region: PRK07756 491915008427 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 491915008428 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 491915008429 gamma subunit interface [polypeptide binding]; other site 491915008430 epsilon subunit interface [polypeptide binding]; other site 491915008431 LBP interface [polypeptide binding]; other site 491915008432 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 491915008433 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 491915008434 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 491915008435 alpha subunit interaction interface [polypeptide binding]; other site 491915008436 Walker A motif; other site 491915008437 ATP binding site [chemical binding]; other site 491915008438 Walker B motif; other site 491915008439 inhibitor binding site; inhibition site 491915008440 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 491915008441 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 491915008442 core domain interface [polypeptide binding]; other site 491915008443 delta subunit interface [polypeptide binding]; other site 491915008444 epsilon subunit interface [polypeptide binding]; other site 491915008445 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 491915008446 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 491915008447 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 491915008448 beta subunit interaction interface [polypeptide binding]; other site 491915008449 Walker A motif; other site 491915008450 ATP binding site [chemical binding]; other site 491915008451 Walker B motif; other site 491915008452 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 491915008453 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 491915008454 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 491915008455 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 491915008456 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 491915008457 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 491915008458 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 491915008459 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 491915008460 ATP synthase I chain; Region: ATP_synt_I; pfam03899 491915008461 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 491915008462 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 491915008463 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 491915008464 active site 491915008465 homodimer interface [polypeptide binding]; other site 491915008466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 491915008467 active site 491915008468 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 491915008469 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 491915008470 dimer interface [polypeptide binding]; other site 491915008471 active site 491915008472 glycine-pyridoxal phosphate binding site [chemical binding]; other site 491915008473 folate binding site [chemical binding]; other site 491915008474 hypothetical protein; Provisional; Region: PRK13690 491915008475 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 491915008476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915008477 dimerization interface [polypeptide binding]; other site 491915008478 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 491915008479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 491915008480 dimer interface [polypeptide binding]; other site 491915008481 putative CheW interface [polypeptide binding]; other site 491915008482 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 491915008483 Low molecular weight phosphatase family; Region: LMWPc; cd00115 491915008484 active site 491915008485 Predicted membrane protein [Function unknown]; Region: COG1971 491915008486 Domain of unknown function DUF; Region: DUF204; pfam02659 491915008487 Domain of unknown function DUF; Region: DUF204; pfam02659 491915008488 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 491915008489 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 491915008490 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 491915008491 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 491915008492 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 491915008493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915008494 S-adenosylmethionine binding site [chemical binding]; other site 491915008495 peptide chain release factor 1; Validated; Region: prfA; PRK00591 491915008496 This domain is found in peptide chain release factors; Region: PCRF; smart00937 491915008497 RF-1 domain; Region: RF-1; pfam00472 491915008498 thymidine kinase; Provisional; Region: PRK04296 491915008499 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 491915008500 transcription termination factor Rho; Provisional; Region: rho; PRK09376 491915008501 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 491915008502 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 491915008503 RNA binding site [nucleotide binding]; other site 491915008504 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 491915008505 multimer interface [polypeptide binding]; other site 491915008506 Walker A motif; other site 491915008507 ATP binding site [chemical binding]; other site 491915008508 Walker B motif; other site 491915008509 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 491915008510 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 491915008511 putative active site [active] 491915008512 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 491915008513 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 491915008514 hinge; other site 491915008515 active site 491915008516 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 491915008517 active site 491915008518 intersubunit interactions; other site 491915008519 catalytic residue [active] 491915008520 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 491915008521 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 491915008522 intersubunit interface [polypeptide binding]; other site 491915008523 active site 491915008524 zinc binding site [ion binding]; other site 491915008525 Na+ binding site [ion binding]; other site 491915008526 Response regulator receiver domain; Region: Response_reg; pfam00072 491915008527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915008528 active site 491915008529 phosphorylation site [posttranslational modification] 491915008530 intermolecular recognition site; other site 491915008531 dimerization interface [polypeptide binding]; other site 491915008532 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 491915008533 CTP synthetase; Validated; Region: pyrG; PRK05380 491915008534 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 491915008535 Catalytic site [active] 491915008536 active site 491915008537 UTP binding site [chemical binding]; other site 491915008538 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 491915008539 active site 491915008540 putative oxyanion hole; other site 491915008541 catalytic triad [active] 491915008542 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 491915008543 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 491915008544 B12 binding site [chemical binding]; other site 491915008545 cobalt ligand [ion binding]; other site 491915008546 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 491915008547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 491915008548 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 491915008549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 491915008550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 491915008551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915008552 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 491915008553 FAD binding site [chemical binding]; other site 491915008554 homotetramer interface [polypeptide binding]; other site 491915008555 substrate binding pocket [chemical binding]; other site 491915008556 catalytic base [active] 491915008557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 491915008558 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 491915008559 FAD binding site [chemical binding]; other site 491915008560 homotetramer interface [polypeptide binding]; other site 491915008561 substrate binding pocket [chemical binding]; other site 491915008562 catalytic base [active] 491915008563 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 491915008564 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 491915008565 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 491915008566 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 491915008567 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 491915008568 dimer interface [polypeptide binding]; other site 491915008569 active site 491915008570 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 491915008571 4Fe-4S binding domain; Region: Fer4; cl02805 491915008572 Cysteine-rich domain; Region: CCG; pfam02754 491915008573 Cysteine-rich domain; Region: CCG; pfam02754 491915008574 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 491915008575 PLD-like domain; Region: PLDc_2; pfam13091 491915008576 putative active site [active] 491915008577 catalytic site [active] 491915008578 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 491915008579 PLD-like domain; Region: PLDc_2; pfam13091 491915008580 putative active site [active] 491915008581 catalytic site [active] 491915008582 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 491915008583 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 491915008584 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 491915008585 active site 491915008586 HIGH motif; other site 491915008587 KMSK motif region; other site 491915008588 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 491915008589 tRNA binding surface [nucleotide binding]; other site 491915008590 anticodon binding site; other site 491915008591 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 491915008592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915008593 Probable transposase; Region: OrfB_IS605; pfam01385 491915008594 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915008595 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 491915008596 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 491915008597 DNA binding residues [nucleotide binding] 491915008598 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 491915008599 catalytic residues [active] 491915008600 catalytic nucleophile [active] 491915008601 VanZ like family; Region: VanZ; pfam04892 491915008602 DDE superfamily endonuclease; Region: DDE_5; cl17874 491915008603 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915008604 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 491915008605 agmatinase; Region: agmatinase; TIGR01230 491915008606 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 491915008607 putative active site [active] 491915008608 Mn binding site [ion binding]; other site 491915008609 spermidine synthase; Provisional; Region: PRK00811 491915008610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915008611 Transglycosylase; Region: Transgly; pfam00912 491915008612 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 491915008613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 491915008614 YwhD family; Region: YwhD; pfam08741 491915008615 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 491915008616 Peptidase family M50; Region: Peptidase_M50; pfam02163 491915008617 active site 491915008618 putative substrate binding region [chemical binding]; other site 491915008619 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 491915008620 active site 1 [active] 491915008621 dimer interface [polypeptide binding]; other site 491915008622 hexamer interface [polypeptide binding]; other site 491915008623 active site 2 [active] 491915008624 Uncharacterized conserved protein [Function unknown]; Region: COG3465 491915008625 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 491915008626 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 491915008627 Zn2+ binding site [ion binding]; other site 491915008628 Mg2+ binding site [ion binding]; other site 491915008629 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 491915008630 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 491915008631 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 491915008632 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 491915008633 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 491915008634 Predicted membrane protein [Function unknown]; Region: COG1238 491915008635 putative heme peroxidase; Provisional; Region: PRK12276 491915008636 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 491915008637 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 491915008638 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 491915008639 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 491915008640 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 491915008641 Ca binding site [ion binding]; other site 491915008642 active site 491915008643 catalytic site [active] 491915008644 Ion channel; Region: Ion_trans_2; pfam07885 491915008645 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 491915008646 TrkA-N domain; Region: TrkA_N; pfam02254 491915008647 TrkA-C domain; Region: TrkA_C; pfam02080 491915008648 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 491915008649 ligand binding site [chemical binding]; other site 491915008650 active site 491915008651 UGI interface [polypeptide binding]; other site 491915008652 catalytic site [active] 491915008653 glycyl-tRNA synthetase; Provisional; Region: PRK04173 491915008654 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 491915008655 motif 1; other site 491915008656 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 491915008657 active site 491915008658 motif 2; other site 491915008659 motif 3; other site 491915008660 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 491915008661 anticodon binding site; other site 491915008662 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 491915008663 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 491915008664 catalytic residue [active] 491915008665 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 491915008666 catalytic residues [active] 491915008667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 491915008668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 491915008669 peroxiredoxin; Region: AhpC; TIGR03137 491915008670 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 491915008671 dimer interface [polypeptide binding]; other site 491915008672 decamer (pentamer of dimers) interface [polypeptide binding]; other site 491915008673 catalytic triad [active] 491915008674 peroxidatic and resolving cysteines [active] 491915008675 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 491915008676 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 491915008677 active site 491915008678 benzoate transport; Region: 2A0115; TIGR00895 491915008679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915008680 putative substrate translocation pore; other site 491915008681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 491915008682 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 491915008683 Probable transposase; Region: OrfB_IS605; pfam01385 491915008684 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 491915008685 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 491915008686 active site 491915008687 catalytic motif [active] 491915008688 Zn binding site [ion binding]; other site 491915008689 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 491915008690 intersubunit interface [polypeptide binding]; other site 491915008691 active site 491915008692 catalytic residue [active] 491915008693 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 491915008694 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 491915008695 Nucleoside recognition; Region: Gate; pfam07670 491915008696 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 491915008697 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 491915008698 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 491915008699 non-specific DNA interactions [nucleotide binding]; other site 491915008700 DNA binding site [nucleotide binding] 491915008701 sequence specific DNA binding site [nucleotide binding]; other site 491915008702 putative cAMP binding site [chemical binding]; other site 491915008703 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 491915008704 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 491915008705 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 491915008706 substrate binding [chemical binding]; other site 491915008707 active site 491915008708 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 491915008709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 491915008710 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 491915008711 putative substrate binding site [chemical binding]; other site 491915008712 putative ATP binding site [chemical binding]; other site 491915008713 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 491915008714 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 491915008715 active site turn [active] 491915008716 phosphorylation site [posttranslational modification] 491915008717 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 491915008718 transcriptional antiterminator BglG; Provisional; Region: PRK09772 491915008719 CAT RNA binding domain; Region: CAT_RBD; smart01061 491915008720 PRD domain; Region: PRD; pfam00874 491915008721 PRD domain; Region: PRD; pfam00874 491915008722 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 491915008723 HPr interaction site; other site 491915008724 glycerol kinase (GK) interaction site [polypeptide binding]; other site 491915008725 active site 491915008726 phosphorylation site [posttranslational modification] 491915008727 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 491915008728 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 491915008729 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 491915008730 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 491915008731 hexamer interface [polypeptide binding]; other site 491915008732 ligand binding site [chemical binding]; other site 491915008733 putative active site [active] 491915008734 NAD(P) binding site [chemical binding]; other site 491915008735 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 491915008736 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 491915008737 Walker A/P-loop; other site 491915008738 ATP binding site [chemical binding]; other site 491915008739 Q-loop/lid; other site 491915008740 ABC transporter signature motif; other site 491915008741 Walker B; other site 491915008742 D-loop; other site 491915008743 H-loop/switch region; other site 491915008744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915008745 dimer interface [polypeptide binding]; other site 491915008746 conserved gate region; other site 491915008747 putative PBP binding loops; other site 491915008748 ABC-ATPase subunit interface; other site 491915008749 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 491915008750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 491915008751 substrate binding pocket [chemical binding]; other site 491915008752 membrane-bound complex binding site; other site 491915008753 hinge residues; other site 491915008754 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 491915008755 Pyruvate formate lyase 1; Region: PFL1; cd01678 491915008756 coenzyme A binding site [chemical binding]; other site 491915008757 active site 491915008758 catalytic residues [active] 491915008759 glycine loop; other site 491915008760 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 491915008761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 491915008762 FeS/SAM binding site; other site 491915008763 beta-phosphoglucomutase; Region: bPGM; TIGR01990 491915008764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 491915008765 motif II; other site 491915008766 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 491915008767 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 491915008768 putative deacylase active site [active] 491915008769 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 491915008770 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 491915008771 Walker A/P-loop; other site 491915008772 ATP binding site [chemical binding]; other site 491915008773 Q-loop/lid; other site 491915008774 ABC transporter signature motif; other site 491915008775 Walker B; other site 491915008776 D-loop; other site 491915008777 H-loop/switch region; other site 491915008778 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 491915008779 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 491915008780 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 491915008781 substrate binding pocket [chemical binding]; other site 491915008782 substrate-Mg2+ binding site; other site 491915008783 aspartate-rich region 1; other site 491915008784 aspartate-rich region 2; other site 491915008785 Transposase domain (DUF772); Region: DUF772; pfam05598 491915008786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915008787 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 491915008788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 491915008789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915008790 ATP binding site [chemical binding]; other site 491915008791 Mg2+ binding site [ion binding]; other site 491915008792 G-X-G motif; other site 491915008793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 491915008794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915008795 active site 491915008796 phosphorylation site [posttranslational modification] 491915008797 intermolecular recognition site; other site 491915008798 dimerization interface [polypeptide binding]; other site 491915008799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 491915008800 DNA binding residues [nucleotide binding] 491915008801 dimerization interface [polypeptide binding]; other site 491915008802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915008803 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 491915008804 Walker A/P-loop; other site 491915008805 ATP binding site [chemical binding]; other site 491915008806 Q-loop/lid; other site 491915008807 ABC transporter signature motif; other site 491915008808 Walker B; other site 491915008809 D-loop; other site 491915008810 H-loop/switch region; other site 491915008811 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 491915008812 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 491915008813 putative catalytic cysteine [active] 491915008814 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 491915008815 putative active site [active] 491915008816 metal binding site [ion binding]; metal-binding site 491915008817 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 491915008818 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 491915008819 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 491915008820 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 491915008821 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 491915008822 [2Fe-2S] cluster binding site [ion binding]; other site 491915008823 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 491915008824 Spore germination protein; Region: Spore_permease; cl17796 491915008825 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 491915008826 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 491915008827 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 491915008828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 491915008829 Walker A/P-loop; other site 491915008830 ATP binding site [chemical binding]; other site 491915008831 Q-loop/lid; other site 491915008832 ABC transporter signature motif; other site 491915008833 Walker B; other site 491915008834 D-loop; other site 491915008835 H-loop/switch region; other site 491915008836 TOBE domain; Region: TOBE_2; pfam08402 491915008837 sulfate transport protein; Provisional; Region: cysT; CHL00187 491915008838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915008839 dimer interface [polypeptide binding]; other site 491915008840 conserved gate region; other site 491915008841 putative PBP binding loops; other site 491915008842 ABC-ATPase subunit interface; other site 491915008843 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 491915008844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 491915008845 dimer interface [polypeptide binding]; other site 491915008846 conserved gate region; other site 491915008847 putative PBP binding loops; other site 491915008848 ABC-ATPase subunit interface; other site 491915008849 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 491915008850 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 491915008851 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 491915008852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 491915008853 putative substrate translocation pore; other site 491915008854 POT family; Region: PTR2; cl17359 491915008855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 491915008856 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 491915008857 Walker A/P-loop; other site 491915008858 ATP binding site [chemical binding]; other site 491915008859 Q-loop/lid; other site 491915008860 ABC transporter signature motif; other site 491915008861 Walker B; other site 491915008862 D-loop; other site 491915008863 H-loop/switch region; other site 491915008864 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 491915008865 FtsX-like permease family; Region: FtsX; pfam02687 491915008866 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 491915008867 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 491915008868 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 491915008869 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 491915008870 YyzF-like protein; Region: YyzF; pfam14116 491915008871 serine endoprotease; Provisional; Region: PRK10898 491915008872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 491915008873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 491915008874 protein binding site [polypeptide binding]; other site 491915008875 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 491915008876 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 491915008877 YycH protein; Region: YycI; pfam09648 491915008878 YycH protein; Region: YycH; pfam07435 491915008879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 491915008880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 491915008881 dimerization interface [polypeptide binding]; other site 491915008882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 491915008883 dimer interface [polypeptide binding]; other site 491915008884 phosphorylation site [posttranslational modification] 491915008885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 491915008886 ATP binding site [chemical binding]; other site 491915008887 Mg2+ binding site [ion binding]; other site 491915008888 G-X-G motif; other site 491915008889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 491915008890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 491915008891 active site 491915008892 phosphorylation site [posttranslational modification] 491915008893 intermolecular recognition site; other site 491915008894 dimerization interface [polypeptide binding]; other site 491915008895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 491915008896 DNA binding site [nucleotide binding] 491915008897 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 491915008898 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 491915008899 GDP-binding site [chemical binding]; other site 491915008900 ACT binding site; other site 491915008901 IMP binding site; other site 491915008902 replicative DNA helicase; Provisional; Region: PRK05748 491915008903 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 491915008904 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 491915008905 Walker A motif; other site 491915008906 ATP binding site [chemical binding]; other site 491915008907 Walker B motif; other site 491915008908 DNA binding loops [nucleotide binding] 491915008909 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 491915008910 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 491915008911 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 491915008912 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 491915008913 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 491915008914 DHH family; Region: DHH; pfam01368 491915008915 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 491915008916 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 491915008917 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 491915008918 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 491915008919 dimer interface [polypeptide binding]; other site 491915008920 ssDNA binding site [nucleotide binding]; other site 491915008921 tetramer (dimer of dimers) interface [polypeptide binding]; other site 491915008922 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 491915008923 GTP-binding protein YchF; Reviewed; Region: PRK09601 491915008924 YchF GTPase; Region: YchF; cd01900 491915008925 G1 box; other site 491915008926 GTP/Mg2+ binding site [chemical binding]; other site 491915008927 Switch I region; other site 491915008928 G2 box; other site 491915008929 Switch II region; other site 491915008930 G3 box; other site 491915008931 G4 box; other site 491915008932 G5 box; other site 491915008933 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 491915008934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 491915008935 mechanosensitive channel MscS; Provisional; Region: PRK10334 491915008936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 491915008937 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 491915008938 Protein of unknown function (DUF554); Region: DUF554; pfam04474 491915008939 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 491915008940 ParB-like nuclease domain; Region: ParB; smart00470 491915008941 KorB domain; Region: KorB; pfam08535 491915008942 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 491915008943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 491915008944 P-loop; other site 491915008945 Magnesium ion binding site [ion binding]; other site 491915008946 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 491915008947 Magnesium ion binding site [ion binding]; other site 491915008948 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 491915008949 ParB-like nuclease domain; Region: ParBc; pfam02195 491915008950 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 491915008951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 491915008952 S-adenosylmethionine binding site [chemical binding]; other site 491915008953 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 491915008954 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 491915008955 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 491915008956 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 491915008957 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 491915008958 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 491915008959 trmE is a tRNA modification GTPase; Region: trmE; cd04164 491915008960 G1 box; other site 491915008961 GTP/Mg2+ binding site [chemical binding]; other site 491915008962 Switch I region; other site 491915008963 G2 box; other site 491915008964 Switch II region; other site 491915008965 G3 box; other site 491915008966 G4 box; other site 491915008967 G5 box; other site 491915008968 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 491915008969 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 491915008970 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 491915008971 G-X-X-G motif; other site 491915008972 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 491915008973 RxxxH motif; other site 491915008974 OxaA-like protein precursor; Validated; Region: PRK02944 491915008975 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 491915008976 ribonuclease P; Reviewed; Region: rnpA; PRK00499 491915008977 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399