-- dump date   	20140618_204508
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
224324000001	elongation factor G; Reviewed; Region: PRK00007
224324000002	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
224324000003	G1 box; other site
224324000004	putative GEF interaction site [polypeptide binding]; other site
224324000005	GTP/Mg2+ binding site [chemical binding]; other site
224324000006	Switch I region; other site
224324000007	G2 box; other site
224324000008	G3 box; other site
224324000009	Switch II region; other site
224324000010	G4 box; other site
224324000011	G5 box; other site
224324000012	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
224324000013	Elongation Factor G, domain II; Region: EFG_II; pfam14492
224324000014	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
224324000015	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
224324000016	elongation factor Tu; Reviewed; Region: PRK00049
224324000017	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
224324000018	G1 box; other site
224324000019	GEF interaction site [polypeptide binding]; other site
224324000020	GTP/Mg2+ binding site [chemical binding]; other site
224324000021	Switch I region; other site
224324000022	G2 box; other site
224324000023	G3 box; other site
224324000024	Switch II region; other site
224324000025	G4 box; other site
224324000026	G5 box; other site
224324000027	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224324000028	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224324000029	Antibiotic Binding Site [chemical binding]; other site
224324000030	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
224324000031	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
224324000032	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
224324000033	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
224324000034	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
224324000035	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
224324000036	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
224324000037	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
224324000038	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
224324000039	protein-rRNA interface [nucleotide binding]; other site
224324000040	putative translocon binding site; other site
224324000041	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
224324000042	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
224324000043	G-X-X-G motif; other site
224324000044	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
224324000045	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
224324000046	23S rRNA interface [nucleotide binding]; other site
224324000047	5S rRNA interface [nucleotide binding]; other site
224324000048	putative antibiotic binding site [chemical binding]; other site
224324000049	L25 interface [polypeptide binding]; other site
224324000050	L27 interface [polypeptide binding]; other site
224324000051	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
224324000052	putative translocon interaction site; other site
224324000053	23S rRNA interface [nucleotide binding]; other site
224324000054	signal recognition particle (SRP54) interaction site; other site
224324000055	L23 interface [polypeptide binding]; other site
224324000056	trigger factor interaction site; other site
224324000057	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
224324000058	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
224324000059	active site
224324000060	catalytic residue [active]
224324000061	dimer interface [polypeptide binding]; other site
224324000062	CAAX protease self-immunity; Region: Abi; pfam02517
224324000063	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
224324000064	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224324000065	inhibitor-cofactor binding pocket; inhibition site
224324000066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324000067	catalytic residue [active]
224324000068	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
224324000069	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
224324000070	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
224324000071	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
224324000072	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
224324000073	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
224324000074	Putative sterol carrier protein [Lipid metabolism]; Region: COG3255
224324000075	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
224324000076	PAS fold; Region: PAS_3; pfam08447
224324000077	PAS domain; Region: PAS_9; pfam13426
224324000078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324000079	putative active site [active]
224324000080	heme pocket [chemical binding]; other site
224324000081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324000082	metal binding site [ion binding]; metal-binding site
224324000083	active site
224324000084	I-site; other site
224324000085	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324000086	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
224324000087	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
224324000088	dimer interface [polypeptide binding]; other site
224324000089	putative functional site; other site
224324000090	putative MPT binding site; other site
224324000091	anion transporter; Region: dass; TIGR00785
224324000092	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
224324000093	transmembrane helices; other site
224324000094	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
224324000095	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
224324000096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324000097	metal binding site [ion binding]; metal-binding site
224324000098	active site
224324000099	I-site; other site
224324000100	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
224324000101	active site
224324000102	(T/H)XGH motif; other site
224324000103	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
224324000104	putative active site [active]
224324000105	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
224324000106	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
224324000107	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
224324000108	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
224324000109	putative active site pocket [active]
224324000110	4-fold oligomerization interface [polypeptide binding]; other site
224324000111	metal binding residues [ion binding]; metal-binding site
224324000112	3-fold/trimer interface [polypeptide binding]; other site
224324000113	Gtr1/RagA G protein conserved region; Region: Gtr1_RagA; pfam04670
224324000114	Uncharacterized protein family UPF0102; Region: UPF0102; pfam02021
224324000115	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
224324000116	cytochrome c-550; Provisional; Region: psbV; cl17239
224324000117	Cytochrome c; Region: Cytochrom_C; cl11414
224324000118	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
224324000119	intrachain domain interface; other site
224324000120	interchain domain interface [polypeptide binding]; other site
224324000121	heme bH binding site [chemical binding]; other site
224324000122	Qi binding site; other site
224324000123	heme bL binding site [chemical binding]; other site
224324000124	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
224324000125	Qo binding site; other site
224324000126	interchain domain interface [polypeptide binding]; other site
224324000127	intrachain domain interface; other site
224324000128	Qi binding site; other site
224324000129	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
224324000130	Qo binding site; other site
224324000131	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
224324000132	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
224324000133	iron-sulfur cluster [ion binding]; other site
224324000134	[2Fe-2S] cluster binding site [ion binding]; other site
224324000135	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
224324000136	heterodimer interface [polypeptide binding]; other site
224324000137	active site
224324000138	FMN binding site [chemical binding]; other site
224324000139	homodimer interface [polypeptide binding]; other site
224324000140	substrate binding site [chemical binding]; other site
224324000141	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
224324000142	aromatic arch; other site
224324000143	DCoH dimer interaction site [polypeptide binding]; other site
224324000144	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
224324000145	DCoH tetramer interaction site [polypeptide binding]; other site
224324000146	substrate binding site [chemical binding]; other site
224324000147	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324000148	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324000149	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
224324000150	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324000151	Surface antigen; Region: Bac_surface_Ag; pfam01103
224324000152	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
224324000153	putative active site [active]
224324000154	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
224324000155	Mg++ binding site [ion binding]; other site
224324000156	putative catalytic motif [active]
224324000157	putative substrate binding site [chemical binding]; other site
224324000158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4752
224324000159	Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578
224324000160	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
224324000161	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
224324000162	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
224324000163	MPT binding site; other site
224324000164	trimer interface [polypeptide binding]; other site
224324000165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000166	S-adenosylmethionine binding site [chemical binding]; other site
224324000167	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
224324000168	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
224324000169	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
224324000170	dimer interface [polypeptide binding]; other site
224324000171	ssDNA binding site [nucleotide binding]; other site
224324000172	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224324000173	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
224324000174	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
224324000175	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
224324000176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000177	S-adenosylmethionine binding site [chemical binding]; other site
224324000178	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
224324000179	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
224324000180	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
224324000181	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
224324000182	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
224324000183	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
224324000184	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
224324000185	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
224324000186	alphaNTD homodimer interface [polypeptide binding]; other site
224324000187	alphaNTD - beta interaction site [polypeptide binding]; other site
224324000188	alphaNTD - beta' interaction site [polypeptide binding]; other site
224324000189	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
224324000190	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
224324000191	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
224324000192	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324000193	RNA binding surface [nucleotide binding]; other site
224324000194	30S ribosomal protein S11; Validated; Region: PRK05309
224324000195	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
224324000196	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
224324000197	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
224324000198	rRNA binding site [nucleotide binding]; other site
224324000199	predicted 30S ribosome binding site; other site
224324000200	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
224324000201	active site
224324000202	adenylate kinase; Reviewed; Region: adk; PRK00279
224324000203	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
224324000204	AMP-binding site [chemical binding]; other site
224324000205	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
224324000206	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
224324000207	SecY translocase; Region: SecY; pfam00344
224324000208	ribosomal protein L28; Region: L28; TIGR00009
224324000209	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
224324000210	Tetramer interface [polypeptide binding]; other site
224324000211	active site
224324000212	FMN-binding site [chemical binding]; other site
224324000213	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
224324000214	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324000215	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
224324000216	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
224324000217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224324000218	dimer interface [polypeptide binding]; other site
224324000219	conserved gate region; other site
224324000220	putative PBP binding loops; other site
224324000221	ABC-ATPase subunit interface; other site
224324000222	Roadblock/LC7 domain [Function unknown]; Region: COG4831
224324000223	Roadblock/LC7 domain [Function unknown]; Region: COG4831
224324000224	Putative sterol carrier protein [Lipid metabolism]; Region: COG3255
224324000225	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
224324000226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324000227	putative active site [active]
224324000228	heme pocket [chemical binding]; other site
224324000229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000230	Walker A motif; other site
224324000231	ATP binding site [chemical binding]; other site
224324000232	Walker B motif; other site
224324000233	arginine finger; other site
224324000234	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224324000235	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
224324000236	ATP cone domain; Region: ATP-cone; pfam03477
224324000237	Class I ribonucleotide reductase; Region: RNR_I; cd01679
224324000238	active site
224324000239	dimer interface [polypeptide binding]; other site
224324000240	catalytic residues [active]
224324000241	effector binding site; other site
224324000242	R2 peptide binding site; other site
224324000243	Preprotein translocase SecG subunit; Region: SecG; pfam03840
224324000244	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
224324000245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000246	S-adenosylmethionine binding site [chemical binding]; other site
224324000247	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224324000248	Domain of unknown function DUF21; Region: DUF21; pfam01595
224324000249	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224324000250	Transporter associated domain; Region: CorC_HlyC; smart01091
224324000251	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
224324000252	active site
224324000253	catalytic triad [active]
224324000254	dimer interface [polypeptide binding]; other site
224324000255	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
224324000256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324000257	Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858
224324000258	bacterial Hfq-like; Region: Hfq; cd01716
224324000259	hexamer interface [polypeptide binding]; other site
224324000260	Sm1 motif; other site
224324000261	RNA binding site [nucleotide binding]; other site
224324000262	Sm2 motif; other site
224324000263	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
224324000264	glutamine synthetase, type I; Region: GlnA; TIGR00653
224324000265	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
224324000266	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
224324000267	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
224324000268	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
224324000269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1978
224324000270	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
224324000271	molybdopterin cofactor binding site; other site
224324000272	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
224324000273	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
224324000274	substrate binding site [chemical binding]; other site
224324000275	hinge regions; other site
224324000276	ADP binding site [chemical binding]; other site
224324000277	catalytic site [active]
224324000278	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
224324000279	active site
224324000280	intersubunit interactions; other site
224324000281	catalytic residue [active]
224324000282	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
224324000283	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324000284	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
224324000285	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
224324000286	dimer interface [polypeptide binding]; other site
224324000287	motif 1; other site
224324000288	active site
224324000289	motif 2; other site
224324000290	motif 3; other site
224324000291	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
224324000292	anticodon binding site; other site
224324000293	ribosomal protein S16; Region: S16; TIGR00002
224324000294	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
224324000295	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
224324000296	Predicted permeases [General function prediction only]; Region: COG0730
224324000297	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
224324000298	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
224324000299	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
224324000300	homopentamer interface [polypeptide binding]; other site
224324000301	active site
224324000302	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
224324000303	putative RNA binding site [nucleotide binding]; other site
224324000304	TIGR00725 family protein; Region: TIGR00725
224324000305	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
224324000306	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
224324000307	putative NAD(P) binding site [chemical binding]; other site
224324000308	active site
224324000309	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
224324000310	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
224324000311	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
224324000312	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
224324000313	catalytic motif [active]
224324000314	Zn binding site [ion binding]; other site
224324000315	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
224324000316	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
224324000317	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
224324000318	active site
224324000319	Riboflavin kinase; Region: Flavokinase; pfam01687
224324000320	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
224324000321	nucleotide binding site/active site [active]
224324000322	HIT family signature motif; other site
224324000323	catalytic residue [active]
224324000324	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
224324000325	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
224324000326	putative active site [active]
224324000327	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
224324000328	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
224324000329	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
224324000330	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
224324000331	intersubunit interface [polypeptide binding]; other site
224324000332	active site
224324000333	catalytic residue [active]
224324000334	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
224324000335	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
224324000336	active site
224324000337	oxalacetate binding site [chemical binding]; other site
224324000338	citrylCoA binding site [chemical binding]; other site
224324000339	coenzyme A binding site [chemical binding]; other site
224324000340	catalytic triad [active]
224324000341	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
224324000342	catalytic residues [active]
224324000343	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
224324000344	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
224324000345	putative active site [active]
224324000346	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
224324000347	D-pathway; other site
224324000348	Predicted membrane protein [Function unknown]; Region: COG2322
224324000349	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
224324000350	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
224324000351	active site
224324000352	Ap6A binding site [chemical binding]; other site
224324000353	nudix motif; other site
224324000354	metal binding site [ion binding]; metal-binding site
224324000355	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
224324000356	catalytic center binding site [active]
224324000357	ATP binding site [chemical binding]; other site
224324000358	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
224324000359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224324000360	active site
224324000361	phosphorylation site [posttranslational modification]
224324000362	intermolecular recognition site; other site
224324000363	dimerization interface [polypeptide binding]; other site
224324000364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000365	Walker A motif; other site
224324000366	ATP binding site [chemical binding]; other site
224324000367	Walker B motif; other site
224324000368	arginine finger; other site
224324000369	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
224324000370	RNA methyltransferase, RsmE family; Region: TIGR00046
224324000371	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
224324000372	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
224324000373	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
224324000374	uncharacterized protein, YfiH family; Region: TIGR00726
224324000375	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
224324000376	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224324000377	inhibitor-cofactor binding pocket; inhibition site
224324000378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324000379	catalytic residue [active]
224324000380	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
224324000381	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224324000382	minor groove reading motif; other site
224324000383	helix-hairpin-helix signature motif; other site
224324000384	substrate binding pocket [chemical binding]; other site
224324000385	active site
224324000386	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
224324000387	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
224324000388	membrane protein insertase; Provisional; Region: PRK01318
224324000389	YidC periplasmic domain; Region: YidC_periplas; pfam14849
224324000390	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
224324000391	hypothetical protein; Provisional; Region: PRK14382
224324000392	F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636
224324000393	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324000394	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
224324000395	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
224324000396	substrate binding site [chemical binding]; other site
224324000397	glutamase interaction surface [polypeptide binding]; other site
224324000398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
224324000399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324000400	TPR motif; other site
224324000401	binding surface
224324000402	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
224324000403	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
224324000404	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
224324000405	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
224324000406	active site
224324000407	nucleotide binding site [chemical binding]; other site
224324000408	HIGH motif; other site
224324000409	KMSKS motif; other site
224324000410	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
224324000411	NAD(P) binding site [chemical binding]; other site
224324000412	catalytic residues [active]
224324000413	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
224324000414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000415	Walker A motif; other site
224324000416	ATP binding site [chemical binding]; other site
224324000417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000418	Walker B motif; other site
224324000419	arginine finger; other site
224324000420	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224324000421	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
224324000422	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224324000423	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224324000424	Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503
224324000425	eRF1 domain 3; Region: eRF1_3; pfam03465
224324000426	Uncharacterized conserved protein [Function unknown]; Region: COG1432
224324000427	LabA_like proteins; Region: LabA; cd10911
224324000428	putative metal binding site [ion binding]; other site
224324000429	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
224324000430	active site
224324000431	dimerization interface [polypeptide binding]; other site
224324000432	F0F1-type ATP synthase, gamma subunit [Energy production and conversion]; Region: AtpG; COG0224
224324000433	core domain interface [polypeptide binding]; other site
224324000434	delta subunit interface [polypeptide binding]; other site
224324000435	epsilon subunit interface [polypeptide binding]; other site
224324000436	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
224324000437	KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878
224324000438	Walker A motif; other site
224324000439	ATP binding site [chemical binding]; other site
224324000440	Walker B motif; other site
224324000441	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
224324000442	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324000443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224324000444	Rotavirus VP2 protein; Region: Rota_VP2; pfam05087
224324000445	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
224324000446	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224324000447	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
224324000448	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
224324000449	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
224324000450	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
224324000451	active site
224324000452	SAM binding site [chemical binding]; other site
224324000453	homodimer interface [polypeptide binding]; other site
224324000454	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
224324000455	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
224324000456	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
224324000457	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
224324000458	heme-binding site [chemical binding]; other site
224324000459	cyanate hydratase; Region: cynS; TIGR00673
224324000460	Helix-turn-helix; Region: HTH_3; pfam01381
224324000461	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
224324000462	oligomer interface [polypeptide binding]; other site
224324000463	active site
224324000464	Nitrogen regulatory protein P-II; Region: P-II; cl00412
224324000465	Nitrogen regulatory protein P-II; Region: P-II; smart00938
224324000466	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
224324000467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224324000468	putative substrate translocation pore; other site
224324000469	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
224324000470	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
224324000471	[4Fe-4S] binding site [ion binding]; other site
224324000472	molybdopterin cofactor binding site; other site
224324000473	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
224324000474	molybdopterin cofactor binding site; other site
224324000475	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
224324000476	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
224324000477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000478	Walker A motif; other site
224324000479	ATP binding site [chemical binding]; other site
224324000480	Walker B motif; other site
224324000481	arginine finger; other site
224324000482	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224324000483	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224324000484	trimer interface [polypeptide binding]; other site
224324000485	active site
224324000486	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
224324000487	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
224324000488	RNase E interface [polypeptide binding]; other site
224324000489	trimer interface [polypeptide binding]; other site
224324000490	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
224324000491	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
224324000492	RNase E interface [polypeptide binding]; other site
224324000493	trimer interface [polypeptide binding]; other site
224324000494	active site
224324000495	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
224324000496	putative nucleic acid binding region [nucleotide binding]; other site
224324000497	G-X-X-G motif; other site
224324000498	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224324000499	RNA binding site [nucleotide binding]; other site
224324000500	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224324000501	RNA binding site [nucleotide binding]; other site
224324000502	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
224324000503	16S/18S rRNA binding site [nucleotide binding]; other site
224324000504	S13e-L30e interaction site [polypeptide binding]; other site
224324000505	25S rRNA binding site [nucleotide binding]; other site
224324000506	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
224324000507	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
224324000508	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
224324000509	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
224324000510	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
224324000511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224324000512	active site
224324000513	phosphorylation site [posttranslational modification]
224324000514	intermolecular recognition site; other site
224324000515	dimerization interface [polypeptide binding]; other site
224324000516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000517	Walker A motif; other site
224324000518	ATP binding site [chemical binding]; other site
224324000519	Walker B motif; other site
224324000520	arginine finger; other site
224324000521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324000522	PAS domain; Region: PAS_9; pfam13426
224324000523	putative active site [active]
224324000524	heme pocket [chemical binding]; other site
224324000525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
224324000526	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224324000527	dimer interface [polypeptide binding]; other site
224324000528	phosphorylation site [posttranslational modification]
224324000529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224324000530	ATP binding site [chemical binding]; other site
224324000531	Mg2+ binding site [ion binding]; other site
224324000532	G-X-G motif; other site
224324000533	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
224324000534	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224324000535	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
224324000536	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
224324000537	SoxF and SoxL family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. SoxF is a subunit of the terminal oxidase supercomplex SoxM in the plasma membrane of Sulfolobus acidocaldarius that combines...; Region: Rieske_SoxF_SoxL; cd03475
224324000538	[2Fe-2S] cluster binding site [ion binding]; other site
224324000539	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
224324000540	GMP synthase; Reviewed; Region: guaA; PRK00074
224324000541	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
224324000542	AMP/PPi binding site [chemical binding]; other site
224324000543	candidate oxyanion hole; other site
224324000544	catalytic triad [active]
224324000545	potential glutamine specificity residues [chemical binding]; other site
224324000546	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
224324000547	ATP Binding subdomain [chemical binding]; other site
224324000548	Ligand Binding sites [chemical binding]; other site
224324000549	Dimerization subdomain; other site
224324000550	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
224324000551	E-class dimer interface [polypeptide binding]; other site
224324000552	P-class dimer interface [polypeptide binding]; other site
224324000553	active site
224324000554	Cu2+ binding site [ion binding]; other site
224324000555	Zn2+ binding site [ion binding]; other site
224324000556	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
224324000557	active site
224324000558	MoxR-like ATPases [General function prediction only]; Region: COG0714
224324000559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000560	Walker A motif; other site
224324000561	ATP binding site [chemical binding]; other site
224324000562	Walker B motif; other site
224324000563	arginine finger; other site
224324000564	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
224324000565	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
224324000566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000567	Walker A motif; other site
224324000568	ATP binding site [chemical binding]; other site
224324000569	Walker B motif; other site
224324000570	arginine finger; other site
224324000571	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
224324000572	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
224324000573	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
224324000574	ATP-grasp domain; Region: ATP-grasp; pfam02222
224324000575	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224324000576	EamA-like transporter family; Region: EamA; cl17759
224324000577	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
224324000578	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
224324000579	Thermostable 8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1059
224324000580	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224324000581	minor groove reading motif; other site
224324000582	helix-hairpin-helix signature motif; other site
224324000583	substrate binding pocket [chemical binding]; other site
224324000584	active site
224324000585	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
224324000586	active site
224324000587	(T/H)XGH motif; other site
224324000588	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK01236
224324000589	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
224324000590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000591	S-adenosylmethionine binding site [chemical binding]; other site
224324000592	transcription termination factor NusA; Region: NusA; TIGR01953
224324000593	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
224324000594	RNA binding site [nucleotide binding]; other site
224324000595	homodimer interface [polypeptide binding]; other site
224324000596	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224324000597	G-X-X-G motif; other site
224324000598	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
224324000599	G-X-X-G motif; other site
224324000600	Sm and related proteins; Region: Sm_like; cl00259
224324000601	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
224324000602	putative oligomer interface [polypeptide binding]; other site
224324000603	putative RNA binding site [nucleotide binding]; other site
224324000604	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
224324000605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000606	S-adenosylmethionine binding site [chemical binding]; other site
224324000607	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
224324000608	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
224324000609	domain interfaces; other site
224324000610	active site
224324000611	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224324000612	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324000613	metal binding site [ion binding]; metal-binding site
224324000614	active site
224324000615	I-site; other site
224324000616	Rrf2 family protein; Region: rrf2_super; TIGR00738
224324000617	Predicted transcriptional regulator [Transcription]; Region: COG1959
224324000618	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
224324000619	active site
224324000620	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
224324000621	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
224324000622	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
224324000623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224324000624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324000625	homodimer interface [polypeptide binding]; other site
224324000626	catalytic residue [active]
224324000627	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
224324000628	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224324000629	catalytic residue [active]
224324000630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
224324000631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224324000632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224324000633	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
224324000634	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224324000635	minor groove reading motif; other site
224324000636	helix-hairpin-helix signature motif; other site
224324000637	substrate binding pocket [chemical binding]; other site
224324000638	active site
224324000639	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
224324000640	Bifunctional nuclease; Region: DNase-RNase; pfam02577
224324000641	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14331
224324000642	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224324000643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324000644	FeS/SAM binding site; other site
224324000645	TRAM domain; Region: TRAM; pfam01938
224324000646	Predicted membrane protein [Function unknown]; Region: COG2862
224324000647	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
224324000648	SmpB-tmRNA interface; other site
224324000649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
224324000650	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
224324000651	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
224324000652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000653	Walker A motif; other site
224324000654	ATP binding site [chemical binding]; other site
224324000655	Walker B motif; other site
224324000656	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
224324000657	Predicted membrane protein [Function unknown]; Region: COG3431
224324000658	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224324000659	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224324000660	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324000661	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
224324000662	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224324000663	FtsX-like permease family; Region: FtsX; pfam02687
224324000664	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224324000665	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224324000666	Walker A/P-loop; other site
224324000667	ATP binding site [chemical binding]; other site
224324000668	Q-loop/lid; other site
224324000669	ABC transporter signature motif; other site
224324000670	Walker B; other site
224324000671	D-loop; other site
224324000672	H-loop/switch region; other site
224324000673	seryl-tRNA synthetase; Provisional; Region: PRK05431
224324000674	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
224324000675	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
224324000676	dimer interface [polypeptide binding]; other site
224324000677	active site
224324000678	motif 1; other site
224324000679	motif 2; other site
224324000680	motif 3; other site
224324000681	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
224324000682	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
224324000683	glutaminase active site [active]
224324000684	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
224324000685	dimer interface [polypeptide binding]; other site
224324000686	active site
224324000687	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
224324000688	dimer interface [polypeptide binding]; other site
224324000689	active site
224324000690	Ion channel; Region: Ion_trans_2; pfam07885
224324000691	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224324000692	TrkA-N domain; Region: TrkA_N; pfam02254
224324000693	TrkA-C domain; Region: TrkA_C; pfam02080
224324000694	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
224324000695	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
224324000696	active site
224324000697	HIGH motif; other site
224324000698	KMSKS motif; other site
224324000699	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
224324000700	tRNA binding surface [nucleotide binding]; other site
224324000701	anticodon binding site; other site
224324000702	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
224324000703	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
224324000704	MutS domain I; Region: MutS_I; pfam01624
224324000705	MutS domain II; Region: MutS_II; pfam05188
224324000706	MutS domain III; Region: MutS_III; pfam05192
224324000707	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
224324000708	Walker A/P-loop; other site
224324000709	ATP binding site [chemical binding]; other site
224324000710	Q-loop/lid; other site
224324000711	ABC transporter signature motif; other site
224324000712	Walker B; other site
224324000713	D-loop; other site
224324000714	H-loop/switch region; other site
224324000715	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
224324000716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000717	S-adenosylmethionine binding site [chemical binding]; other site
224324000718	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
224324000719	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
224324000720	tetramer interfaces [polypeptide binding]; other site
224324000721	binuclear metal-binding site [ion binding]; other site
224324000722	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224324000723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224324000724	dimer interface [polypeptide binding]; other site
224324000725	phosphorylation site [posttranslational modification]
224324000726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224324000727	ATP binding site [chemical binding]; other site
224324000728	Mg2+ binding site [ion binding]; other site
224324000729	G-X-G motif; other site
224324000730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224324000731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224324000732	active site
224324000733	phosphorylation site [posttranslational modification]
224324000734	intermolecular recognition site; other site
224324000735	dimerization interface [polypeptide binding]; other site
224324000736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
224324000737	DNA binding site [nucleotide binding]
224324000738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224324000739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224324000740	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
224324000741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324000742	Walker A motif; other site
224324000743	ATP binding site [chemical binding]; other site
224324000744	Walker B motif; other site
224324000745	arginine finger; other site
224324000746	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
224324000747	DnaA box-binding interface [nucleotide binding]; other site
224324000748	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
224324000749	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
224324000750	active site
224324000751	catalytic tetrad [active]
224324000752	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
224324000753	ParB-like nuclease domain; Region: ParBc; pfam02195
224324000754	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
224324000755	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
224324000756	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
224324000757	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
224324000758	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224324000759	Putative lysophospholipase; Region: Hydrolase_4; cl19140
224324000760	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
224324000761	Ferritin-like domain; Region: Ferritin; pfam00210
224324000762	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
224324000763	dinuclear metal binding motif [ion binding]; other site
224324000764	Ferritin-like domain; Region: Ferritin; pfam00210
224324000765	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
224324000766	dinuclear metal binding motif [ion binding]; other site
224324000767	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
224324000768	substrate binding site [chemical binding]; other site
224324000769	active site
224324000770	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
224324000771	active site
224324000772	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
224324000773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324000774	S-adenosylmethionine binding site [chemical binding]; other site
224324000775	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
224324000776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324000777	PAS domain; Region: PAS_9; pfam13426
224324000778	putative active site [active]
224324000779	heme pocket [chemical binding]; other site
224324000780	GAF domain; Region: GAF_2; pfam13185
224324000781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324000782	PAS domain; Region: PAS_9; pfam13426
224324000783	putative active site [active]
224324000784	heme pocket [chemical binding]; other site
224324000785	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324000786	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
224324000787	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
224324000788	homodimer interface [polypeptide binding]; other site
224324000789	metal binding site [ion binding]; metal-binding site
224324000790	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
224324000791	homodimer interface [polypeptide binding]; other site
224324000792	active site
224324000793	putative chemical substrate binding site [chemical binding]; other site
224324000794	metal binding site [ion binding]; metal-binding site
224324000795	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
224324000796	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
224324000797	Nucleotide binding site [chemical binding]; other site
224324000798	DTAP/Switch II; other site
224324000799	Switch I; other site
224324000800	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
224324000801	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
224324000802	NADP binding site [chemical binding]; other site
224324000803	homopentamer interface [polypeptide binding]; other site
224324000804	substrate binding site [chemical binding]; other site
224324000805	active site
224324000806	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
224324000807	metal ion-dependent adhesion site (MIDAS); other site
224324000808	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
224324000809	putative active site [active]
224324000810	catalytic residue [active]
224324000811	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
224324000812	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
224324000813	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
224324000814	dimerization interface [polypeptide binding]; other site
224324000815	active site
224324000816	tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133
224324000817	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
224324000818	HIGH motif; other site
224324000819	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224324000820	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224324000821	conserved hypothetical integral membrane protein; Region: TIGR00056
224324000822	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
224324000823	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
224324000824	active site
224324000825	catalytic residues [active]
224324000826	metal binding site [ion binding]; metal-binding site
224324000827	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
224324000828	Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747
224324000829	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
224324000830	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324000831	ATP binding site [chemical binding]; other site
224324000832	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
224324000833	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074
224324000834	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
224324000835	substrate binding site [chemical binding]; other site
224324000836	dimer interface [polypeptide binding]; other site
224324000837	catalytic triad [active]
224324000838	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
224324000839	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
224324000840	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
224324000841	homotrimer interaction site [polypeptide binding]; other site
224324000842	putative active site [active]
224324000843	prolyl-tRNA synthetase; Provisional; Region: PRK09194
224324000844	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
224324000845	dimer interface [polypeptide binding]; other site
224324000846	motif 1; other site
224324000847	active site
224324000848	motif 2; other site
224324000849	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
224324000850	putative deacylase active site [active]
224324000851	motif 3; other site
224324000852	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
224324000853	anticodon binding site; other site
224324000854	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324000855	metal binding site [ion binding]; metal-binding site
224324000856	active site
224324000857	I-site; other site
224324000858	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324000859	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
224324000860	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
224324000861	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
224324000862	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
224324000863	CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639
224324000864	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09665
224324000865	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cd09658
224324000866	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cd09650
224324000867	Proline dehydrogenase; Region: Pro_dh; pfam01619
224324000868	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
224324000869	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09681
224324000870	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09660
224324000871	CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661
224324000872	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682
224324000873	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cd09657
224324000874	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
224324000875	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09654
224324000876	CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336
224324000877	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09656
224324000878	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
224324000879	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
224324000880	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224324000881	CPxP  motif; other site
224324000882	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
224324000883	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
224324000884	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
224324000885	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
224324000886	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
224324000887	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324000888	Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110
224324000889	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
224324000890	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324000891	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
224324000892	Cysteine-rich domain; Region: CCG; pfam02754
224324000893	Cysteine-rich domain; Region: CCG; pfam02754
224324000894	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
224324000895	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224324000896	lipoyl attachment site [posttranslational modification]; other site
224324000897	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
224324000898	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324000899	FeS/SAM binding site; other site
224324000900	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
224324000901	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
224324000902	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
224324000903	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
224324000904	Predicted integral membrane protein [Function unknown]; Region: COG0392
224324000905	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
224324000906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324000907	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
224324000908	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
224324000909	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
224324000910	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224324000911	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
224324000912	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
224324000913	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
224324000914	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
224324000915	catalytic site [active]
224324000916	subunit interface [polypeptide binding]; other site
224324000917	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
224324000918	DHH family; Region: DHH; pfam01368
224324000919	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
224324000920	FOG: CBS domain [General function prediction only]; Region: COG0517
224324000921	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
224324000922	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
224324000923	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
224324000924	active site
224324000925	NTP binding site [chemical binding]; other site
224324000926	metal binding triad [ion binding]; metal-binding site
224324000927	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
224324000928	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
224324000929	Walker A/P-loop; other site
224324000930	ATP binding site [chemical binding]; other site
224324000931	Q-loop/lid; other site
224324000932	ABC transporter signature motif; other site
224324000933	Walker B; other site
224324000934	D-loop; other site
224324000935	H-loop/switch region; other site
224324000936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400
224324000937	TrkA-N domain; Region: TrkA_N; pfam02254
224324000938	TrkA-C domain; Region: TrkA_C; pfam02080
224324000939	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324000940	Ligand Binding Site [chemical binding]; other site
224324000941	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
224324000942	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
224324000943	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324000944	FeS/SAM binding site; other site
224324000945	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
224324000946	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
224324000947	Walker A/P-loop; other site
224324000948	ATP binding site [chemical binding]; other site
224324000949	Q-loop/lid; other site
224324000950	ABC transporter signature motif; other site
224324000951	Walker B; other site
224324000952	D-loop; other site
224324000953	H-loop/switch region; other site
224324000954	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
224324000955	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
224324000956	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224324000957	catalytic residues [active]
224324000958	HNH/Endo VII superfamily nuclease toxin with a HHH motif; Region: Tox-HNH-HHH; pfam15637
224324000959	aspartate aminotransferase; Provisional; Region: PRK05764
224324000960	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224324000961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324000962	homodimer interface [polypeptide binding]; other site
224324000963	catalytic residue [active]
224324000964	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
224324000965	dimer interface [polypeptide binding]; other site
224324000966	putative tRNA-binding site [nucleotide binding]; other site
224324000967	ScpA/B protein; Region: ScpA_ScpB; pfam02616
224324000968	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
224324000969	homodimer interface [polypeptide binding]; other site
224324000970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324000971	catalytic residue [active]
224324000972	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
224324000973	putative active site [active]
224324000974	dimerization interface [polypeptide binding]; other site
224324000975	putative tRNAtyr binding site [nucleotide binding]; other site
224324000976	DsrH like protein; Region: DsrH; cl17347
224324000977	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324000978	metal binding site [ion binding]; metal-binding site
224324000979	active site
224324000980	I-site; other site
224324000981	LabA_like proteins; Region: LabA; cd10911
224324000982	Uncharacterized conserved protein [Function unknown]; Region: COG1432
224324000983	putative metal binding site [ion binding]; other site
224324000984	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
224324000985	dimer interface [polypeptide binding]; other site
224324000986	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
224324000987	glycerol kinase; Region: glycerol_kin; TIGR01311
224324000988	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
224324000989	N- and C-terminal domain interface [polypeptide binding]; other site
224324000990	active site
224324000991	MgATP binding site [chemical binding]; other site
224324000992	catalytic site [active]
224324000993	metal binding site [ion binding]; metal-binding site
224324000994	glycerol binding site [chemical binding]; other site
224324000995	homotetramer interface [polypeptide binding]; other site
224324000996	homodimer interface [polypeptide binding]; other site
224324000997	FBP binding site [chemical binding]; other site
224324000998	protein IIAGlc interface [polypeptide binding]; other site
224324000999	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
224324001000	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
224324001001	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224324001002	catalytic loop [active]
224324001003	iron binding site [ion binding]; other site
224324001004	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
224324001005	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324001006	4Fe-4S binding domain; Region: Fer4; pfam00037
224324001007	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
224324001008	molybdopterin cofactor binding site; other site
224324001009	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
224324001010	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
224324001011	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
224324001012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001013	S-adenosylmethionine binding site [chemical binding]; other site
224324001014	Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975
224324001015	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
224324001016	catalytic residues [active]
224324001017	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
224324001018	catalytic residues [active]
224324001019	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
224324001020	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
224324001021	MgtC family; Region: MgtC; pfam02308
224324001022	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
224324001023	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
224324001024	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
224324001025	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
224324001026	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
224324001027	PYR/PP interface [polypeptide binding]; other site
224324001028	dimer interface [polypeptide binding]; other site
224324001029	TPP binding site [chemical binding]; other site
224324001030	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
224324001031	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
224324001032	TPP-binding site [chemical binding]; other site
224324001033	dimer interface [polypeptide binding]; other site
224324001034	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
224324001035	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
224324001036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001037	FeS/SAM binding site; other site
224324001038	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
224324001039	Sulphur oxygenase reductase; Region: SOR; pfam07682
224324001040	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
224324001041	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224324001042	catalytic triad [active]
224324001043	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
224324001044	active site
224324001045	Zn binding site [ion binding]; other site
224324001046	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224324001047	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
224324001048	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
224324001049	GatB domain; Region: GatB_Yqey; smart00845
224324001050	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
224324001051	Outer membrane efflux protein; Region: OEP; pfam02321
224324001052	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224324001053	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
224324001054	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324001055	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
224324001056	MMPL family; Region: MMPL; cl14618
224324001057	MMPL family; Region: MMPL; cl14618
224324001058	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224324001059	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
224324001060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001061	FeS/SAM binding site; other site
224324001062	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
224324001063	tetramerization interface [polypeptide binding]; other site
224324001064	active site
224324001065	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224324001066	active site residue [active]
224324001067	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
224324001068	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
224324001069	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
224324001070	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
224324001071	dimer interface [polypeptide binding]; other site
224324001072	active site
224324001073	glycine-pyridoxal phosphate binding site [chemical binding]; other site
224324001074	folate binding site [chemical binding]; other site
224324001075	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
224324001076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224324001077	dimer interface [polypeptide binding]; other site
224324001078	conserved gate region; other site
224324001079	putative PBP binding loops; other site
224324001080	ABC-ATPase subunit interface; other site
224324001081	enolase; Provisional; Region: eno; PRK00077
224324001082	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
224324001083	dimer interface [polypeptide binding]; other site
224324001084	metal binding site [ion binding]; metal-binding site
224324001085	substrate binding pocket [chemical binding]; other site
224324001086	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224324001087	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
224324001088	dimer interface [polypeptide binding]; other site
224324001089	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224324001090	catalytic triad [active]
224324001091	peroxidatic and resolving cysteines [active]
224324001092	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
224324001093	dimer interface [polypeptide binding]; other site
224324001094	catalytic triad [active]
224324001095	peroxidatic and resolving cysteines [active]
224324001096	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
224324001097	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224324001098	ligand binding site [chemical binding]; other site
224324001099	flexible hinge region; other site
224324001100	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
224324001101	putative switch regulator; other site
224324001102	non-specific DNA interactions [nucleotide binding]; other site
224324001103	DNA binding site [nucleotide binding]
224324001104	sequence specific DNA binding site [nucleotide binding]; other site
224324001105	putative cAMP binding site [chemical binding]; other site
224324001106	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
224324001107	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
224324001108	catalytic triad [active]
224324001109	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
224324001110	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
224324001111	minor groove reading motif; other site
224324001112	helix-hairpin-helix signature motif; other site
224324001113	substrate binding pocket [chemical binding]; other site
224324001114	active site
224324001115	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
224324001116	Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Region: Zwf; COG0364
224324001117	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
224324001118	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
224324001119	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
224324001120	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
224324001121	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
224324001122	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
224324001123	ParB-like nuclease domain; Region: ParBc; pfam02195
224324001124	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
224324001125	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
224324001126	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324001127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224324001128	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324001129	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
224324001130	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
224324001131	active site
224324001132	substrate binding site [chemical binding]; other site
224324001133	metal binding site [ion binding]; metal-binding site
224324001134	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
224324001135	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
224324001136	SLBB domain; Region: SLBB; pfam10531
224324001137	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
224324001138	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
224324001139	SLBB domain; Region: SLBB; pfam10531
224324001140	SLBB domain; Region: SLBB; pfam10531
224324001141	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
224324001142	SLBB domain; Region: SLBB; pfam10531
224324001143	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
224324001144	Chain length determinant protein; Region: Wzz; pfam02706
224324001145	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
224324001146	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
224324001147	active site
224324001148	NTP binding site [chemical binding]; other site
224324001149	metal binding triad [ion binding]; metal-binding site
224324001150	antibiotic binding site [chemical binding]; other site
224324001151	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
224324001152	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
224324001153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001154	S-adenosylmethionine binding site [chemical binding]; other site
224324001155	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
224324001156	FAD binding domain; Region: FAD_binding_4; cl19922
224324001157	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
224324001158	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
224324001159	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
224324001160	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
224324001161	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324001162	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324001163	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
224324001164	putative ADP-binding pocket [chemical binding]; other site
224324001165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224324001166	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
224324001167	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
224324001168	Mg++ binding site [ion binding]; other site
224324001169	putative catalytic motif [active]
224324001170	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
224324001171	FAD binding domain; Region: FAD_binding_4; pfam01565
224324001172	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
224324001173	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
224324001174	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
224324001175	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
224324001176	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
224324001177	cell division protein FtsA; Region: ftsA; TIGR01174
224324001178	Cell division protein FtsA; Region: FtsA; smart00842
224324001179	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224324001180	nucleotide binding site [chemical binding]; other site
224324001181	Cell division protein FtsA; Region: FtsA; pfam14450
224324001182	cell division protein FtsZ; Validated; Region: PRK09330
224324001183	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
224324001184	nucleotide binding site [chemical binding]; other site
224324001185	SulA interaction site; other site
224324001186	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
224324001187	trimer interface [polypeptide binding]; other site
224324001188	dimer interface [polypeptide binding]; other site
224324001189	putative active site [active]
224324001190	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
224324001191	archaeoflavoprotein AfpA; Region: archaeo_AfpA; TIGR02699
224324001192	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
224324001193	N-terminal plug; other site
224324001194	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
224324001195	ligand-binding site [chemical binding]; other site
224324001196	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
224324001197	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
224324001198	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
224324001199	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
224324001200	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
224324001201	putative RNA binding site [nucleotide binding]; other site
224324001202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001203	S-adenosylmethionine binding site [chemical binding]; other site
224324001204	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
224324001205	MarC family integral membrane protein; Region: MarC; pfam01914
224324001206	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
224324001207	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324001208	active site
224324001209	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
224324001210	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
224324001211	metal binding site [ion binding]; metal-binding site
224324001212	dimer interface [polypeptide binding]; other site
224324001213	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
224324001214	Active_site [active]
224324001215	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
224324001216	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
224324001217	glutamine binding [chemical binding]; other site
224324001218	catalytic triad [active]
224324001219	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
224324001220	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
224324001221	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
224324001222	DNA repair protein RadA; Provisional; Region: PRK11823
224324001223	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
224324001224	Walker A motif/ATP binding site; other site
224324001225	ATP binding site [chemical binding]; other site
224324001226	Walker B motif; other site
224324001227	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
224324001228	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
224324001229	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
224324001230	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224324001231	catalytic loop [active]
224324001232	iron binding site [ion binding]; other site
224324001233	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324001234	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224324001235	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324001236	RNA binding surface [nucleotide binding]; other site
224324001237	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
224324001238	active site
224324001239	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
224324001240	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
224324001241	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224324001242	AAA domain; Region: AAA_26; pfam13500
224324001243	Protein of unknown function (DUF1611); Region: DUF1611; cl19508
224324001244	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
224324001245	active site
224324001246	ADP binding site [chemical binding]; other site
224324001247	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224324001248	thiamine phosphate binding site [chemical binding]; other site
224324001249	active site
224324001250	pyrophosphate binding site [ion binding]; other site
224324001251	DNA repair protein RecN; Region: recN; TIGR00634
224324001252	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
224324001253	Walker A/P-loop; other site
224324001254	ATP binding site [chemical binding]; other site
224324001255	Q-loop/lid; other site
224324001256	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
224324001257	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
224324001258	ABC transporter signature motif; other site
224324001259	Walker B; other site
224324001260	D-loop; other site
224324001261	H-loop/switch region; other site
224324001262	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
224324001263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324001264	metal binding site [ion binding]; metal-binding site
224324001265	active site
224324001266	I-site; other site
224324001267	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
224324001268	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
224324001269	putative ribose interaction site [chemical binding]; other site
224324001270	putative ADP binding site [chemical binding]; other site
224324001271	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
224324001272	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
224324001273	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
224324001274	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
224324001275	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224324001276	Coenzyme A binding pocket [chemical binding]; other site
224324001277	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
224324001278	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
224324001279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324001280	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
224324001281	putative ADP-binding pocket [chemical binding]; other site
224324001282	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
224324001283	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
224324001284	SLBB domain; Region: SLBB; pfam10531
224324001285	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
224324001286	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
224324001287	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
224324001288	putative dimer interface [polypeptide binding]; other site
224324001289	[2Fe-2S] cluster binding site [ion binding]; other site
224324001290	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
224324001291	active site
224324001292	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
224324001293	Catalytic domain of Protein Kinases; Region: PKc; cd00180
224324001294	active site
224324001295	ATP binding site [chemical binding]; other site
224324001296	substrate binding site [chemical binding]; other site
224324001297	activation loop (A-loop); other site
224324001298	Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112
224324001299	active site
224324001300	substrate binding site [chemical binding]; other site
224324001301	ATP binding site [chemical binding]; other site
224324001302	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
224324001303	active site
224324001304	catalytic residues [active]
224324001305	metal binding site [ion binding]; metal-binding site
224324001306	anthranilate synthase component I; Provisional; Region: PRK13565
224324001307	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
224324001308	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224324001309	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
224324001310	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
224324001311	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
224324001312	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
224324001313	active site
224324001314	putative substrate binding pocket [chemical binding]; other site
224324001315	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
224324001316	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
224324001317	Substrate binding site; other site
224324001318	Cupin domain; Region: Cupin_2; cl17218
224324001319	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
224324001320	SurA N-terminal domain; Region: SurA_N_3; cl07813
224324001321	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
224324001322	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
224324001323	L-aspartate oxidase; Provisional; Region: PRK06175
224324001324	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
224324001325	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
224324001326	adenylosuccinate lyase; Region: purB; TIGR00928
224324001327	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
224324001328	tetramer interface [polypeptide binding]; other site
224324001329	active site
224324001330	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
224324001331	Uncharacterized conserved protein [Function unknown]; Region: COG3439
224324001332	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
224324001333	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
224324001334	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
224324001335	Predicted transcriptional regulators [Transcription]; Region: COG1318
224324001336	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224324001337	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
224324001338	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
224324001339	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
224324001340	active site
224324001341	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
224324001342	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
224324001343	Substrate binding site; other site
224324001344	Mg++ binding site; other site
224324001345	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
224324001346	active site
224324001347	substrate binding site [chemical binding]; other site
224324001348	CoA binding site [chemical binding]; other site
224324001349	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
224324001350	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
224324001351	homodimer interface [polypeptide binding]; other site
224324001352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324001353	catalytic residue [active]
224324001354	GTP-binding protein YchF; Reviewed; Region: PRK09601
224324001355	YchF GTPase; Region: YchF; cd01900
224324001356	G1 box; other site
224324001357	GTP/Mg2+ binding site [chemical binding]; other site
224324001358	Switch I region; other site
224324001359	G2 box; other site
224324001360	Switch II region; other site
224324001361	G3 box; other site
224324001362	G4 box; other site
224324001363	G5 box; other site
224324001364	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
224324001365	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
224324001366	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
224324001367	intracellular protease, PfpI family; Region: PfpI; TIGR01382
224324001368	proposed catalytic triad [active]
224324001369	conserved cys residue [active]
224324001370	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
224324001371	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
224324001372	metal binding site [ion binding]; metal-binding site
224324001373	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
224324001374	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
224324001375	Uncharacterized conserved protein [Function unknown]; Region: COG1565
224324001376	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
224324001377	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
224324001378	Transglycosylase; Region: Transgly; pfam00912
224324001379	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
224324001380	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
224324001381	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
224324001382	substrate-cofactor binding pocket; other site
224324001383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324001384	catalytic residue [active]
224324001385	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
224324001386	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
224324001387	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
224324001388	MoaE interaction surface [polypeptide binding]; other site
224324001389	MoeB interaction surface [polypeptide binding]; other site
224324001390	thiocarboxylated glycine; other site
224324001391	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
224324001392	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
224324001393	Walker A/P-loop; other site
224324001394	ATP binding site [chemical binding]; other site
224324001395	Q-loop/lid; other site
224324001396	ABC transporter signature motif; other site
224324001397	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
224324001398	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
224324001399	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
224324001400	ABC transporter signature motif; other site
224324001401	Walker B; other site
224324001402	D-loop; other site
224324001403	H-loop/switch region; other site
224324001404	radical SAM protein, TIGR01212 family; Region: TIGR01212
224324001405	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001406	FeS/SAM binding site; other site
224324001407	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
224324001408	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
224324001409	nucleotide binding pocket [chemical binding]; other site
224324001410	K-X-D-G motif; other site
224324001411	catalytic site [active]
224324001412	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
224324001413	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
224324001414	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
224324001415	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
224324001416	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
224324001417	Dimer interface [polypeptide binding]; other site
224324001418	BRCT sequence motif; other site
224324001419	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
224324001420	active site
224324001421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224324001422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224324001423	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
224324001424	putative dimerization interface [polypeptide binding]; other site
224324001425	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
224324001426	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
224324001427	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
224324001428	putative active site [active]
224324001429	adenylation catalytic residue [active]
224324001430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022
224324001431	Uncharacterized conserved protein [Function unknown]; Region: COG1700
224324001432	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
224324001433	Protein of unknown function (DUF524); Region: DUF524; pfam04411
224324001434	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
224324001435	AAA domain; Region: AAA_22; pfam13401
224324001436	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
224324001437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001438	FeS/SAM binding site; other site
224324001439	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
224324001440	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224324001441	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224324001442	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224324001443	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
224324001444	Peptidase family M23; Region: Peptidase_M23; pfam01551
224324001445	MgtE intracellular N domain; Region: MgtE_N; cl15244
224324001446	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
224324001447	FliG middle domain; Region: FliG_M; pfam14841
224324001448	FliG C-terminal domain; Region: FliG_C; pfam01706
224324001449	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
224324001450	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224324001451	catalytic loop [active]
224324001452	iron binding site [ion binding]; other site
224324001453	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324001454	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
224324001455	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
224324001456	active site
224324001457	interdomain interaction site; other site
224324001458	putative metal-binding site [ion binding]; other site
224324001459	nucleotide binding site [chemical binding]; other site
224324001460	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224324001461	domain I; other site
224324001462	DNA binding groove [nucleotide binding]
224324001463	phosphate binding site [ion binding]; other site
224324001464	domain II; other site
224324001465	domain III; other site
224324001466	nucleotide binding site [chemical binding]; other site
224324001467	catalytic site [active]
224324001468	domain IV; other site
224324001469	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
224324001470	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
224324001471	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
224324001472	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
224324001473	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
224324001474	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
224324001475	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
224324001476	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
224324001477	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
224324001478	putative substrate-binding site; other site
224324001479	nickel binding site [ion binding]; other site
224324001480	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
224324001481	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
224324001482	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
224324001483	Acylphosphatase; Region: Acylphosphatase; pfam00708
224324001484	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
224324001485	HypF finger; Region: zf-HYPF; pfam07503
224324001486	HypF finger; Region: zf-HYPF; pfam07503
224324001487	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
224324001488	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
224324001489	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
224324001490	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
224324001491	gamma subunit interface [polypeptide binding]; other site
224324001492	epsilon subunit interface [polypeptide binding]; other site
224324001493	LBP interface [polypeptide binding]; other site
224324001494	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
224324001495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001496	S-adenosylmethionine binding site [chemical binding]; other site
224324001497	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
224324001498	chromosome segregation protein; Provisional; Region: PRK01156
224324001499	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
224324001500	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224324001501	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
224324001502	beta subunit interaction interface [polypeptide binding]; other site
224324001503	Walker A motif; other site
224324001504	ATP binding site [chemical binding]; other site
224324001505	Walker B motif; other site
224324001506	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224324001507	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
224324001508	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
224324001509	P loop; other site
224324001510	Nucleotide binding site [chemical binding]; other site
224324001511	DTAP/Switch II; other site
224324001512	Switch I; other site
224324001513	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
224324001514	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
224324001515	putative active site [active]
224324001516	putative metal binding site [ion binding]; other site
224324001517	Low molecular weight phosphatase family; Region: LMWPc; cd00115
224324001518	active site
224324001519	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
224324001520	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
224324001521	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
224324001522	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
224324001523	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
224324001524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324001525	metal binding site [ion binding]; metal-binding site
224324001526	active site
224324001527	I-site; other site
224324001528	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
224324001529	Glucose inhibited division protein A; Region: GIDA; pfam01134
224324001530	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
224324001531	Ligand binding site; other site
224324001532	oligomer interface; other site
224324001533	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
224324001534	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224324001535	MMPL family; Region: MMPL; cl14618
224324001536	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224324001537	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
224324001538	Outer membrane efflux protein; Region: OEP; pfam02321
224324001539	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324001540	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
224324001541	Outer membrane efflux protein; Region: OEP; pfam02321
224324001542	Outer membrane efflux protein; Region: OEP; pfam02321
224324001543	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
224324001544	Ligand Binding Site [chemical binding]; other site
224324001545	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
224324001546	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
224324001547	DNA binding residues [nucleotide binding]
224324001548	putative dimer interface [polypeptide binding]; other site
224324001549	chaperone protein DnaJ; Provisional; Region: PRK14291
224324001550	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224324001551	HSP70 interaction site [polypeptide binding]; other site
224324001552	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224324001553	substrate binding site [polypeptide binding]; other site
224324001554	dimer interface [polypeptide binding]; other site
224324001555	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
224324001556	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
224324001557	RNA binding site [nucleotide binding]; other site
224324001558	active site
224324001559	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
224324001560	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
224324001561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324001562	catalytic residue [active]
224324001563	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
224324001564	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
224324001565	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
224324001566	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
224324001567	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
224324001568	Staphylococcal nuclease homologues; Region: SNc; smart00318
224324001569	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
224324001570	Catalytic site; other site
224324001571	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
224324001572	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
224324001573	hinge region; other site
224324001574	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
224324001575	putative nucleotide binding site [chemical binding]; other site
224324001576	uridine monophosphate binding site [chemical binding]; other site
224324001577	homohexameric interface [polypeptide binding]; other site
224324001578	elongation factor Ts; Provisional; Region: tsf; PRK09377
224324001579	UBA/TS-N domain; Region: UBA; pfam00627
224324001580	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
224324001581	Probable transposase; Region: OrfB_IS605; pfam01385
224324001582	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
224324001583	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224324001584	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
224324001585	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
224324001586	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
224324001587	active site
224324001588	Substrate binding site; other site
224324001589	Mg++ binding site; other site
224324001590	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
224324001591	putative trimer interface [polypeptide binding]; other site
224324001592	putative CoA binding site [chemical binding]; other site
224324001593	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
224324001594	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
224324001595	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
224324001596	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
224324001597	putative active site [active]
224324001598	catalytic site [active]
224324001599	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
224324001600	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
224324001601	ADP-binding pocket [chemical binding]; other site
224324001602	homodimer interface [polypeptide binding]; other site
224324001603	glycogen branching enzyme; Provisional; Region: PRK12313
224324001604	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
224324001605	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
224324001606	active site
224324001607	catalytic site [active]
224324001608	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
224324001609	4-alpha-glucanotransferase; Provisional; Region: PRK14508
224324001610	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
224324001611	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
224324001612	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224324001613	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
224324001614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324001615	motif II; other site
224324001616	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
224324001617	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
224324001618	D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187
224324001619	ligand binding site [chemical binding]; other site
224324001620	NAD binding site [chemical binding]; other site
224324001621	homodimer interface [polypeptide binding]; other site
224324001622	catalytic site [active]
224324001623	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
224324001624	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
224324001625	dimer interface [polypeptide binding]; other site
224324001626	active site
224324001627	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224324001628	catalytic residues [active]
224324001629	substrate binding site [chemical binding]; other site
224324001630	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
224324001631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001632	FeS/SAM binding site; other site
224324001633	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
224324001634	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
224324001635	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
224324001636	putative active site [active]
224324001637	oxyanion strand; other site
224324001638	catalytic triad [active]
224324001639	30S ribosomal protein S7; Validated; Region: PRK05302
224324001640	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
224324001641	S17 interaction site [polypeptide binding]; other site
224324001642	S8 interaction site; other site
224324001643	16S rRNA interaction site [nucleotide binding]; other site
224324001644	streptomycin interaction site [chemical binding]; other site
224324001645	23S rRNA interaction site [nucleotide binding]; other site
224324001646	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
224324001647	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
224324001648	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324001649	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224324001650	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324001651	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
224324001652	Domain of unknown function DUF59; Region: DUF59; cl00941
224324001653	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
224324001654	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
224324001655	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224324001656	catalytic residue [active]
224324001657	Domain of unknown function DUF20; Region: UPF0118; pfam01594
224324001658	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
224324001659	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
224324001660	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
224324001661	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
224324001662	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
224324001663	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
224324001664	Walker A motif; other site
224324001665	ATP binding site [chemical binding]; other site
224324001666	Walker B motif; other site
224324001667	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
224324001668	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224324001669	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224324001670	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224324001671	substrate binding pocket [chemical binding]; other site
224324001672	chain length determination region; other site
224324001673	substrate-Mg2+ binding site; other site
224324001674	catalytic residues [active]
224324001675	aspartate-rich region 1; other site
224324001676	active site lid residues [active]
224324001677	aspartate-rich region 2; other site
224324001678	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
224324001679	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
224324001680	dimerization interface 3.5A [polypeptide binding]; other site
224324001681	active site
224324001682	bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128
224324001683	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
224324001684	dimer interface [polypeptide binding]; other site
224324001685	active site
224324001686	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
224324001687	dimer interface [polypeptide binding]; other site
224324001688	active site
224324001689	Uncharacterized conserved protein [Function unknown]; Region: COG1542
224324001690	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
224324001691	Uncharacterized conserved protein [Function unknown]; Region: COG1851
224324001692	Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta...; Region: Prefoldin_alpha; cd00584
224324001693	prefoldin alpha/beta subunit interface [polypeptide binding]; other site
224324001694	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
224324001695	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
224324001696	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
224324001697	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
224324001698	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
224324001699	motif 1; other site
224324001700	dimer interface [polypeptide binding]; other site
224324001701	active site
224324001702	motif 2; other site
224324001703	motif 3; other site
224324001704	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
224324001705	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224324001706	Bacterial transcriptional regulator; Region: IclR; pfam01614
224324001707	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224324001708	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
224324001709	Hamartin protein; Region: Hamartin; pfam04388
224324001710	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
224324001711	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
224324001712	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
224324001713	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
224324001714	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
224324001715	dimerization interface [polypeptide binding]; other site
224324001716	putative ATP binding site [chemical binding]; other site
224324001717	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
224324001718	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324001719	RNA binding surface [nucleotide binding]; other site
224324001720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001721	S-adenosylmethionine binding site [chemical binding]; other site
224324001722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
224324001723	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
224324001724	dimerization interface [polypeptide binding]; other site
224324001725	L-aspartate oxidase; Provisional; Region: PRK06175
224324001726	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
224324001727	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
224324001728	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
224324001729	phosphate binding site [ion binding]; other site
224324001730	putative substrate binding pocket [chemical binding]; other site
224324001731	dimer interface [polypeptide binding]; other site
224324001732	Immunoglobulin domain; Region: Ig; cl11960
224324001733	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
224324001734	histidinol dehydrogenase; Region: hisD; TIGR00069
224324001735	NAD binding site [chemical binding]; other site
224324001736	dimerization interface [polypeptide binding]; other site
224324001737	product binding site; other site
224324001738	substrate binding site [chemical binding]; other site
224324001739	zinc binding site [ion binding]; other site
224324001740	catalytic residues [active]
224324001741	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
224324001742	MMPL family; Region: MMPL; cl14618
224324001743	MMPL family; Region: MMPL; cl14618
224324001744	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224324001745	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
224324001746	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001747	FeS/SAM binding site; other site
224324001748	DNA helicase, putative; Region: TIGR00376
224324001749	Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654
224324001750	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
224324001751	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
224324001752	Part of AAA domain; Region: AAA_19; pfam13245
224324001753	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
224324001754	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
224324001755	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
224324001756	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
224324001757	protein binding site [polypeptide binding]; other site
224324001758	Catalytic dyad [active]
224324001759	UGMP family protein; Validated; Region: PRK09604
224324001760	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
224324001761	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224324001762	nucleotide binding site [chemical binding]; other site
224324001763	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
224324001764	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
224324001765	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
224324001766	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
224324001767	dihydroorotase; Validated; Region: pyrC; PRK09357
224324001768	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224324001769	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
224324001770	active site
224324001771	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
224324001772	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263
224324001773	Predicted membrane protein [Function unknown]; Region: COG4244
224324001774	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224324001775	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224324001776	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
224324001777	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
224324001778	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
224324001779	active site
224324001780	Flavoprotein; Region: Flavoprotein; cl19190
224324001781	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
224324001782	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
224324001783	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
224324001784	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
224324001785	inhibitor-cofactor binding pocket; inhibition site
224324001786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324001787	catalytic residue [active]
224324001788	conserved hypothetical protein; Region: TIGR00374
224324001789	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
224324001790	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
224324001791	putative active site [active]
224324001792	catalytic triad [active]
224324001793	putative dimer interface [polypeptide binding]; other site
224324001794	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224324001795	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
224324001796	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224324001797	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224324001798	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
224324001799	Ligand Binding Site [chemical binding]; other site
224324001800	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
224324001801	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
224324001802	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
224324001803	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
224324001804	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224324001805	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
224324001806	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224324001807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
224324001808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324001809	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224324001810	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
224324001811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324001812	S-adenosylmethionine binding site [chemical binding]; other site
224324001813	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
224324001814	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
224324001815	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
224324001816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224324001817	Zn2+ binding site [ion binding]; other site
224324001818	Mg2+ binding site [ion binding]; other site
224324001819	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
224324001820	synthetase active site [active]
224324001821	NTP binding site [chemical binding]; other site
224324001822	metal binding site [ion binding]; metal-binding site
224324001823	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
224324001824	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
224324001825	rod shape-determining protein MreB; Provisional; Region: PRK13930
224324001826	MreB and similar proteins; Region: MreB_like; cd10225
224324001827	nucleotide binding site [chemical binding]; other site
224324001828	Mg binding site [ion binding]; other site
224324001829	putative protofilament interaction site [polypeptide binding]; other site
224324001830	RodZ interaction site [polypeptide binding]; other site
224324001831	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
224324001832	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
224324001833	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
224324001834	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
224324001835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324001836	FeS/SAM binding site; other site
224324001837	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
224324001838	Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like; cd12825
224324001839	Cl binding site [ion binding]; other site
224324001840	oligomer interface [polypeptide binding]; other site
224324001841	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
224324001842	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
224324001843	active site
224324001844	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224324001845	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324001846	binding surface
224324001847	TPR motif; other site
224324001848	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224324001849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324001850	binding surface
224324001851	TPR motif; other site
224324001852	Tetratricopeptide repeat; Region: TPR_19; pfam14559
224324001853	Tetratricopeptide repeat; Region: TPR_19; pfam14559
224324001854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324001855	binding surface
224324001856	TPR motif; other site
224324001857	Tetratricopeptide repeat; Region: TPR_15; pfam13429
224324001858	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324001859	binding surface
224324001860	TPR motif; other site
224324001861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324001862	binding surface
224324001863	TPR motif; other site
224324001864	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324001865	Ligand Binding Site [chemical binding]; other site
224324001866	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324001867	Ligand Binding Site [chemical binding]; other site
224324001868	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
224324001869	active site
224324001870	substrate binding site [chemical binding]; other site
224324001871	cosubstrate binding site; other site
224324001872	catalytic site [active]
224324001873	peroxiredoxin; Provisional; Region: PRK13189
224324001874	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
224324001875	dimer interface [polypeptide binding]; other site
224324001876	decamer (pentamer of dimers) interface [polypeptide binding]; other site
224324001877	catalytic triad [active]
224324001878	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
224324001879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
224324001880	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
224324001881	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324001882	Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828
224324001883	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
224324001884	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
224324001885	dimerization interface [polypeptide binding]; other site
224324001886	active site
224324001887	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
224324001888	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
224324001889	trmE is a tRNA modification GTPase; Region: trmE; cd04164
224324001890	G1 box; other site
224324001891	GTP/Mg2+ binding site [chemical binding]; other site
224324001892	Switch I region; other site
224324001893	G2 box; other site
224324001894	Switch II region; other site
224324001895	G3 box; other site
224324001896	G4 box; other site
224324001897	G5 box; other site
224324001898	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
224324001899	transcription termination factor Rho; Provisional; Region: rho; PRK09376
224324001900	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
224324001901	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
224324001902	RNA binding site [nucleotide binding]; other site
224324001903	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
224324001904	multimer interface [polypeptide binding]; other site
224324001905	Walker A motif; other site
224324001906	ATP binding site [chemical binding]; other site
224324001907	Walker B motif; other site
224324001908	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
224324001909	peptide chain release factor 1; Validated; Region: prfA; PRK00591
224324001910	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224324001911	RF-1 domain; Region: RF-1; pfam00472
224324001912	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
224324001913	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
224324001914	P-loop; other site
224324001915	ADP binding residues [chemical binding]; other site
224324001916	Switch I; other site
224324001917	Switch II; other site
224324001918	septum site-determining protein MinC; Region: minC; TIGR01222
224324001919	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
224324001920	hypothetical protein; Provisional; Region: PRK04358
224324001921	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
224324001922	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
224324001923	TPP-binding site; other site
224324001924	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224324001925	PYR/PP interface [polypeptide binding]; other site
224324001926	dimer interface [polypeptide binding]; other site
224324001927	TPP binding site [chemical binding]; other site
224324001928	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224324001929	reverse gyrase; Region: rgy; TIGR01054
224324001930	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324001931	ATP binding site [chemical binding]; other site
224324001932	putative Mg++ binding site [ion binding]; other site
224324001933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224324001934	nucleotide binding region [chemical binding]; other site
224324001935	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
224324001936	active site
224324001937	metal binding site [ion binding]; metal-binding site
224324001938	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224324001939	domain I; other site
224324001940	DNA binding groove [nucleotide binding]
224324001941	phosphate binding site [ion binding]; other site
224324001942	domain II; other site
224324001943	domain III; other site
224324001944	nucleotide binding site [chemical binding]; other site
224324001945	catalytic site [active]
224324001946	domain IV; other site
224324001947	Uncharacterized conserved protein [Function unknown]; Region: COG5502
224324001948	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
224324001949	putative ligand binding pocket/active site [active]
224324001950	putative metal binding site [ion binding]; other site
224324001951	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
224324001952	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224324001953	nucleotide binding site [chemical binding]; other site
224324001954	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
224324001955	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
224324001956	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
224324001957	Uncharacterized conserved protein [Function unknown]; Region: COG1578
224324001958	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
224324001959	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
224324001960	substrate binding pocket [chemical binding]; other site
224324001961	chain length determination region; other site
224324001962	substrate-Mg2+ binding site; other site
224324001963	catalytic residues [active]
224324001964	aspartate-rich region 1; other site
224324001965	active site lid residues [active]
224324001966	aspartate-rich region 2; other site
224324001967	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
224324001968	trimerization site [polypeptide binding]; other site
224324001969	active site
224324001970	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
224324001971	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
224324001972	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
224324001973	shikimate binding site; other site
224324001974	NAD(P) binding site [chemical binding]; other site
224324001975	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
224324001976	nucleoside/Zn binding site; other site
224324001977	dimer interface [polypeptide binding]; other site
224324001978	catalytic motif [active]
224324001979	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
224324001980	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
224324001981	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224324001982	dimerization interface [polypeptide binding]; other site
224324001983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224324001984	dimer interface [polypeptide binding]; other site
224324001985	phosphorylation site [posttranslational modification]
224324001986	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
224324001987	PhoU domain; Region: PhoU; pfam01895
224324001988	PhoU domain; Region: PhoU; pfam01895
224324001989	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
224324001990	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
224324001991	dimer interface [polypeptide binding]; other site
224324001992	active site
224324001993	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
224324001994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324001995	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224324001996	Walker A motif; other site
224324001997	ATP binding site [chemical binding]; other site
224324001998	Walker B motif; other site
224324001999	arginine finger; other site
224324002000	prohibitin homologues; Region: PHB; smart00244
224324002001	Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826
224324002002	trimer interface [polypeptide binding]; other site
224324002003	Domain of unknown function (DUF202); Region: DUF202; pfam02656
224324002004	Predicted membrane protein [Function unknown]; Region: COG2149
224324002005	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611
224324002006	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
224324002007	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
224324002008	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
224324002009	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
224324002010	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
224324002011	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
224324002012	Fe binding site [ion binding]; other site
224324002013	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
224324002014	catalytic loop [active]
224324002015	iron binding site [ion binding]; other site
224324002016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002017	TPR motif; other site
224324002018	binding surface
224324002019	TPR repeat; Region: TPR_11; pfam13414
224324002020	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
224324002021	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224324002022	P loop; other site
224324002023	GTP binding site [chemical binding]; other site
224324002024	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
224324002025	NADPH bind site [chemical binding]; other site
224324002026	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
224324002027	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
224324002028	putative FMN binding site [chemical binding]; other site
224324002029	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
224324002030	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
224324002031	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
224324002032	active site
224324002033	HIGH motif; other site
224324002034	KMSK motif region; other site
224324002035	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224324002036	tRNA binding surface [nucleotide binding]; other site
224324002037	anticodon binding site; other site
224324002038	ribonuclease PH; Reviewed; Region: rph; PRK00173
224324002039	Ribonuclease PH; Region: RNase_PH_bact; cd11362
224324002040	hexamer interface [polypeptide binding]; other site
224324002041	active site
224324002042	Uncharacterized conserved protein [Function unknown]; Region: COG1801
224324002043	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
224324002044	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
224324002045	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
224324002046	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224324002047	active site
224324002048	catalytic site [active]
224324002049	substrate binding site [chemical binding]; other site
224324002050	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
224324002051	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
224324002052	active site
224324002053	FtsH Extracellular; Region: FtsH_ext; pfam06480
224324002054	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
224324002055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324002056	Walker A motif; other site
224324002057	ATP binding site [chemical binding]; other site
224324002058	Walker B motif; other site
224324002059	arginine finger; other site
224324002060	Peptidase family M41; Region: Peptidase_M41; pfam01434
224324002061	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
224324002062	substrate binding site [chemical binding]; other site
224324002063	ligand binding site [chemical binding]; other site
224324002064	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
224324002065	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224324002066	lipoyl attachment site [posttranslational modification]; other site
224324002067	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
224324002068	dimer interface [polypeptide binding]; other site
224324002069	motif 1; other site
224324002070	active site
224324002071	motif 2; other site
224324002072	motif 3; other site
224324002073	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
224324002074	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
224324002075	dimerization interface [polypeptide binding]; other site
224324002076	active site
224324002077	metal binding site [ion binding]; metal-binding site
224324002078	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
224324002079	dsRNA binding site [nucleotide binding]; other site
224324002080	Ferrochelatase; Region: Ferrochelatase; pfam00762
224324002081	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
224324002082	C-terminal domain interface [polypeptide binding]; other site
224324002083	active site
224324002084	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
224324002085	active site
224324002086	N-terminal domain interface [polypeptide binding]; other site
224324002087	Chorismate mutase type II; Region: CM_2; pfam01817
224324002088	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
224324002089	Prephenate dehydratase; Region: PDT; pfam00800
224324002090	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
224324002091	putative L-Phe binding site [chemical binding]; other site
224324002092	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
224324002093	23S rRNA binding site [nucleotide binding]; other site
224324002094	L21 binding site [polypeptide binding]; other site
224324002095	L13 binding site [polypeptide binding]; other site
224324002096	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
224324002097	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
224324002098	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
224324002099	dimer interface [polypeptide binding]; other site
224324002100	motif 1; other site
224324002101	active site
224324002102	motif 2; other site
224324002103	motif 3; other site
224324002104	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
224324002105	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
224324002106	Catalytic site [active]
224324002107	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
224324002108	homotrimer interaction site [polypeptide binding]; other site
224324002109	zinc binding site [ion binding]; other site
224324002110	CDP-binding sites; other site
224324002111	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
224324002112	NAD synthetase; Provisional; Region: PRK13981
224324002113	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
224324002114	multimer interface [polypeptide binding]; other site
224324002115	active site
224324002116	catalytic triad [active]
224324002117	protein interface 1 [polypeptide binding]; other site
224324002118	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
224324002119	homodimer interface [polypeptide binding]; other site
224324002120	NAD binding pocket [chemical binding]; other site
224324002121	ATP binding pocket [chemical binding]; other site
224324002122	Mg binding site [ion binding]; other site
224324002123	active-site loop [active]
224324002124	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
224324002125	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
224324002126	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324002127	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
224324002128	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
224324002129	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
224324002130	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
224324002131	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
224324002132	Organic solvent tolerance protein; Region: OstA_C; pfam04453
224324002133	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
224324002134	substrate binding site [chemical binding]; other site
224324002135	hexamer interface [polypeptide binding]; other site
224324002136	metal binding site [ion binding]; metal-binding site
224324002137	thymidylate kinase; Validated; Region: tmk; PRK00698
224324002138	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
224324002139	TMP-binding site; other site
224324002140	ATP-binding site [chemical binding]; other site
224324002141	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
224324002142	heterotetramer interface [polypeptide binding]; other site
224324002143	active site pocket [active]
224324002144	cleavage site
224324002145	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
224324002146	Peptidase family M48; Region: Peptidase_M48; pfam01435
224324002147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002148	binding surface
224324002149	TPR motif; other site
224324002150	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002151	binding surface
224324002152	TPR motif; other site
224324002153	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
224324002154	protein-export membrane protein SecD; Region: secD; TIGR01129
224324002155	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
224324002156	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224324002157	biotin synthase; Region: bioB; TIGR00433
224324002158	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324002159	FeS/SAM binding site; other site
224324002160	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
224324002161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
224324002162	Uncharacterized conserved protein [Function unknown]; Region: COG1683
224324002163	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
224324002164	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
224324002165	Moco binding site; other site
224324002166	metal coordination site [ion binding]; other site
224324002167	DNA gyrase subunit A; Validated; Region: PRK05560
224324002168	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
224324002169	CAP-like domain; other site
224324002170	active site
224324002171	primary dimer interface [polypeptide binding]; other site
224324002172	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224324002173	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224324002174	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
224324002175	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
224324002176	active site
224324002177	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
224324002178	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
224324002179	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
224324002180	putative ADP-ribose binding site [chemical binding]; other site
224324002181	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
224324002182	Cu(I) binding site [ion binding]; other site
224324002183	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
224324002184	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224324002185	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
224324002186	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
224324002187	active site
224324002188	HIGH motif; other site
224324002189	dimer interface [polypeptide binding]; other site
224324002190	KMSKS motif; other site
224324002191	PHP domain; Region: PHP; pfam02811
224324002192	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
224324002193	active site
224324002194	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
224324002195	catalytic triad [active]
224324002196	metal binding site [ion binding]; metal-binding site
224324002197	conserved cis-peptide bond; other site
224324002198	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
224324002199	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
224324002200	nucleotide binding site [chemical binding]; other site
224324002201	NEF interaction site [polypeptide binding]; other site
224324002202	SBD interface [polypeptide binding]; other site
224324002203	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
224324002204	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
224324002205	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
224324002206	acyl-activating enzyme (AAE) consensus motif; other site
224324002207	putative AMP binding site [chemical binding]; other site
224324002208	putative active site [active]
224324002209	putative CoA binding site [chemical binding]; other site
224324002210	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
224324002211	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
224324002212	putative acyl-acceptor binding pocket; other site
224324002213	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
224324002214	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
224324002215	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224324002216	ligand binding site [chemical binding]; other site
224324002217	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
224324002218	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
224324002219	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224324002220	ligand binding site [chemical binding]; other site
224324002221	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
224324002222	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
224324002223	exonuclease SbcC; Region: sbcc; TIGR00618
224324002224	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
224324002225	Walker A/P-loop; other site
224324002226	ATP binding site [chemical binding]; other site
224324002227	Q-loop/lid; other site
224324002228	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176
224324002229	linker region; other site
224324002230	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
224324002231	ABC transporter signature motif; other site
224324002232	Walker B; other site
224324002233	D-loop; other site
224324002234	H-loop/switch region; other site
224324002235	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
224324002236	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
224324002237	active site
224324002238	PHP Thumb interface [polypeptide binding]; other site
224324002239	metal binding site [ion binding]; metal-binding site
224324002240	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
224324002241	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
224324002242	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
224324002243	generic binding surface I; other site
224324002244	generic binding surface II; other site
224324002245	short chain dehydrogenase; Provisional; Region: PRK09134
224324002246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
224324002247	NAD(P) binding site [chemical binding]; other site
224324002248	active site
224324002249	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
224324002250	Mechanosensitive ion channel; Region: MS_channel; pfam00924
224324002251	putative protease; Provisional; Region: PRK15452
224324002252	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
224324002253	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342
224324002254	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
224324002255	non-specific DNA binding site [nucleotide binding]; other site
224324002256	salt bridge; other site
224324002257	sequence-specific DNA binding site [nucleotide binding]; other site
224324002258	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
224324002259	dimerization interface [polypeptide binding]; other site
224324002260	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
224324002261	ATP binding site [chemical binding]; other site
224324002262	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
224324002263	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
224324002264	active site
224324002265	Zn binding site [ion binding]; other site
224324002266	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324002267	Ligand Binding Site [chemical binding]; other site
224324002268	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
224324002269	Ligand Binding Site [chemical binding]; other site
224324002270	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
224324002271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224324002272	ATP binding site [chemical binding]; other site
224324002273	Mg2+ binding site [ion binding]; other site
224324002274	G-X-G motif; other site
224324002275	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
224324002276	anchoring element; other site
224324002277	dimer interface [polypeptide binding]; other site
224324002278	ATP binding site [chemical binding]; other site
224324002279	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
224324002280	active site
224324002281	putative metal-binding site [ion binding]; other site
224324002282	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
224324002283	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
224324002284	selenium donor protein; Region: selD; TIGR00476
224324002285	dimerization interface [polypeptide binding]; other site
224324002286	putative ATP binding site [chemical binding]; other site
224324002287	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
224324002288	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
224324002289	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224324002290	catalytic residue [active]
224324002291	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
224324002292	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
224324002293	G1 box; other site
224324002294	putative GEF interaction site [polypeptide binding]; other site
224324002295	GTP/Mg2+ binding site [chemical binding]; other site
224324002296	Switch I region; other site
224324002297	G2 box; other site
224324002298	G3 box; other site
224324002299	Switch II region; other site
224324002300	G4 box; other site
224324002301	G5 box; other site
224324002302	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
224324002303	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
224324002304	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
224324002305	Transcriptional regulator [Transcription]; Region: LysR; COG0583
224324002306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
224324002307	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
224324002308	dimerization interface [polypeptide binding]; other site
224324002309	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
224324002310	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
224324002311	[4Fe-4S] binding site [ion binding]; other site
224324002312	molybdopterin cofactor binding site; other site
224324002313	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
224324002314	molybdopterin cofactor binding site; other site
224324002315	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
224324002316	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
224324002317	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
224324002318	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
224324002319	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
224324002320	E-class dimer interface [polypeptide binding]; other site
224324002321	P-class dimer interface [polypeptide binding]; other site
224324002322	active site
224324002323	Cu2+ binding site [ion binding]; other site
224324002324	Zn2+ binding site [ion binding]; other site
224324002325	Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058
224324002326	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224324002327	lipoyl attachment site [posttranslational modification]; other site
224324002328	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
224324002329	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
224324002330	catalytic residue [active]
224324002331	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
224324002332	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
224324002333	putative active site [active]
224324002334	putative metal binding site [ion binding]; other site
224324002335	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
224324002336	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
224324002337	Walker A/P-loop; other site
224324002338	ATP binding site [chemical binding]; other site
224324002339	Q-loop/lid; other site
224324002340	ABC transporter signature motif; other site
224324002341	Walker B; other site
224324002342	D-loop; other site
224324002343	H-loop/switch region; other site
224324002344	putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513
224324002345	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
224324002346	active site
224324002347	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
224324002348	RimM N-terminal domain; Region: RimM; pfam01782
224324002349	PRC-barrel domain; Region: PRC; pfam05239
224324002350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224324002351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224324002352	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
224324002353	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
224324002354	Outer membrane efflux protein; Region: OEP; pfam02321
224324002355	Outer membrane efflux protein; Region: OEP; pfam02321
224324002356	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
224324002357	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
224324002358	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
224324002359	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324002360	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
224324002361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224324002362	putative substrate translocation pore; other site
224324002363	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
224324002364	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
224324002365	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
224324002366	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
224324002367	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
224324002368	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
224324002369	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
224324002370	active site
224324002371	HIGH motif; other site
224324002372	KMSKS motif; other site
224324002373	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
224324002374	anticodon binding site; other site
224324002375	tRNA binding surface [nucleotide binding]; other site
224324002376	UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179
224324002377	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
224324002378	NAD binding site [chemical binding]; other site
224324002379	homodimer interface [polypeptide binding]; other site
224324002380	active site
224324002381	substrate binding site [chemical binding]; other site
224324002382	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
224324002383	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
224324002384	putative catalytic cysteine [active]
224324002385	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
224324002386	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
224324002387	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
224324002388	active site residue [active]
224324002389	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
224324002390	active site residue [active]
224324002391	Acyltransferase family; Region: Acyl_transf_3; cl19154
224324002392	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
224324002393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324002394	S-adenosylmethionine binding site [chemical binding]; other site
224324002395	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324002396	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224324002397	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324002398	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
224324002399	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
224324002400	ATP-sulfurylase; Region: ATPS; cd00517
224324002401	active site
224324002402	HXXH motif; other site
224324002403	flexible loop; other site
224324002404	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
224324002405	ligand-binding site [chemical binding]; other site
224324002406	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
224324002407	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
224324002408	NADP-binding site; other site
224324002409	homotetramer interface [polypeptide binding]; other site
224324002410	substrate binding site [chemical binding]; other site
224324002411	homodimer interface [polypeptide binding]; other site
224324002412	active site
224324002413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324002414	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
224324002415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002416	binding surface
224324002417	TPR motif; other site
224324002418	TPR repeat; Region: TPR_11; pfam13414
224324002419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002420	binding surface
224324002421	TPR motif; other site
224324002422	TPR repeat; Region: TPR_11; pfam13414
224324002423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002424	binding surface
224324002425	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224324002426	TPR motif; other site
224324002427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324002428	binding surface
224324002429	TPR motif; other site
224324002430	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
224324002431	Protein of unknown function (DUF3491); Region: DUF3491; pfam11996
224324002432	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
224324002433	Outer membrane efflux protein; Region: OEP; pfam02321
224324002434	Outer membrane efflux protein; Region: OEP; pfam02321
224324002435	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
224324002436	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
224324002437	Walker A/P-loop; other site
224324002438	ATP binding site [chemical binding]; other site
224324002439	Q-loop/lid; other site
224324002440	ABC transporter signature motif; other site
224324002441	Walker B; other site
224324002442	D-loop; other site
224324002443	H-loop/switch region; other site
224324002444	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
224324002445	putative carbohydrate binding site [chemical binding]; other site
224324002446	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
224324002447	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
224324002448	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324002449	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
224324002450	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224324002451	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
224324002452	Walker A/P-loop; other site
224324002453	ATP binding site [chemical binding]; other site
224324002454	Q-loop/lid; other site
224324002455	ABC transporter signature motif; other site
224324002456	Walker B; other site
224324002457	D-loop; other site
224324002458	H-loop/switch region; other site
224324002459	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
224324002460	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
224324002461	dimer interface [polypeptide binding]; other site
224324002462	active site
224324002463	CoA binding pocket [chemical binding]; other site
224324002464	putative phosphate acyltransferase; Provisional; Region: PRK05331
224324002465	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
224324002466	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
224324002467	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
224324002468	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
224324002469	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
224324002470	Glutamine amidotransferase class-I; Region: GATase; pfam00117
224324002471	putative active site [active]
224324002472	catalytic triad [active]
224324002473	Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894
224324002474	active site
224324002475	dimer interface [polypeptide binding]; other site
224324002476	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
224324002477	MoaE interaction surface [polypeptide binding]; other site
224324002478	MoeB interaction surface [polypeptide binding]; other site
224324002479	thiocarboxylated glycine; other site
224324002480	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224324002481	lipoyl attachment site [posttranslational modification]; other site
224324002482	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
224324002483	tetramer interface [polypeptide binding]; other site
224324002484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324002485	catalytic residue [active]
224324002486	Uncharacterized conserved protein [Function unknown]; Region: COG1656
224324002487	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
224324002488	putative SAM binding site [chemical binding]; other site
224324002489	putative homodimer interface [polypeptide binding]; other site
224324002490	ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392
224324002491	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
224324002492	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
224324002493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324002494	putative active site [active]
224324002495	heme pocket [chemical binding]; other site
224324002496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
224324002497	dimer interface [polypeptide binding]; other site
224324002498	phosphorylation site [posttranslational modification]
224324002499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224324002500	ATP binding site [chemical binding]; other site
224324002501	Mg2+ binding site [ion binding]; other site
224324002502	G-X-G motif; other site
224324002503	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
224324002504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
224324002505	active site
224324002506	phosphorylation site [posttranslational modification]
224324002507	intermolecular recognition site; other site
224324002508	dimerization interface [polypeptide binding]; other site
224324002509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324002510	Walker A motif; other site
224324002511	ATP binding site [chemical binding]; other site
224324002512	Walker B motif; other site
224324002513	arginine finger; other site
224324002514	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224324002515	Uncharacterized conserved protein [Function unknown]; Region: COG1416
224324002516	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
224324002517	MMPL family; Region: MMPL; cl14618
224324002518	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
224324002519	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224324002520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324002521	motif II; other site
224324002522	Predicted metal-binding protein [General function prediction only]; Region: COG3019
224324002523	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
224324002524	The first cupredoxin domain of multicopper oxidase McoP and similar proteins; Region: CuRO_1_McoP_like; cd13852
224324002525	Domain 2 interface [polypeptide binding]; other site
224324002526	Domain 3 interface [polypeptide binding]; other site
224324002527	trinuclear Cu binding site [ion binding]; other site
224324002528	The second cupredoxin domain of multicopper oxidase McoP and similar proteins; Region: CuRO_2_McoP_like; cd13879
224324002529	putative Domain 1 interface [polypeptide binding]; other site
224324002530	putative Domain 3 interface [polypeptide binding]; other site
224324002531	The third cupredoxin domain of multicopper oxidase McoP and similar proteins; Region: CuRO_3_McoP_like; cd13888
224324002532	Domain 2 interface [polypeptide binding]; other site
224324002533	Domain 1 interface [polypeptide binding]; other site
224324002534	Type 1 (T1) Cu binding site [ion binding]; other site
224324002535	trinuclear Cu binding site [ion binding]; other site
224324002536	YtkA-like; Region: YtkA; pfam13115
224324002537	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
224324002538	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324002539	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
224324002540	Outer membrane efflux protein; Region: OEP; pfam02321
224324002541	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
224324002542	glutamate 5-kinase; Region: proB; TIGR01027
224324002543	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
224324002544	nucleotide binding site [chemical binding]; other site
224324002545	homotetrameric interface [polypeptide binding]; other site
224324002546	putative phosphate binding site [ion binding]; other site
224324002547	putative allosteric binding site; other site
224324002548	PUA domain; Region: PUA; pfam01472
224324002549	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; pfam02899
224324002550	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
224324002551	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
224324002552	active site
224324002553	catalytic residues [active]
224324002554	DNA binding site [nucleotide binding]
224324002555	Int/Topo IB signature motif; other site
224324002556	ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120
224324002557	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
224324002558	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
224324002559	ANP binding site [chemical binding]; other site
224324002560	Substrate Binding Site II [chemical binding]; other site
224324002561	Substrate Binding Site I [chemical binding]; other site
224324002562	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324002563	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
224324002564	Domain of unknown function (DUF377); Region: DUF377; pfam04041
224324002565	active site
224324002566	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
224324002567	dimer interface [polypeptide binding]; other site
224324002568	active site
224324002569	catalytic residue [active]
224324002570	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
224324002571	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
224324002572	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
224324002573	active site
224324002574	NAD binding site [chemical binding]; other site
224324002575	metal binding site [ion binding]; metal-binding site
224324002576	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
224324002577	PAS domain S-box; Region: sensory_box; TIGR00229
224324002578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324002579	putative active site [active]
224324002580	heme pocket [chemical binding]; other site
224324002581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324002582	metal binding site [ion binding]; metal-binding site
224324002583	active site
224324002584	I-site; other site
224324002585	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324002586	aspartate kinase; Reviewed; Region: PRK06635
224324002587	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
224324002588	putative nucleotide binding site [chemical binding]; other site
224324002589	putative catalytic residues [active]
224324002590	putative Mg ion binding site [ion binding]; other site
224324002591	putative aspartate binding site [chemical binding]; other site
224324002592	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
224324002593	putative allosteric regulatory site; other site
224324002594	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
224324002595	putative allosteric regulatory residue; other site
224324002596	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
224324002597	S-adenosylmethionine synthetase; Region: metK; TIGR01034
224324002598	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
224324002599	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
224324002600	ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705
224324002601	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
224324002602	dimer interface [polypeptide binding]; other site
224324002603	motif 1; other site
224324002604	active site
224324002605	motif 2; other site
224324002606	motif 3; other site
224324002607	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
224324002608	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
224324002609	putative active site [active]
224324002610	putative substrate binding site [chemical binding]; other site
224324002611	putative cosubstrate binding site; other site
224324002612	catalytic site [active]
224324002613	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
224324002614	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
224324002615	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
224324002616	substrate binding site [chemical binding]; other site
224324002617	oxyanion hole (OAH) forming residues; other site
224324002618	trimer interface [polypeptide binding]; other site
224324002619	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
224324002620	reverse gyrase; Region: rgy; TIGR01054
224324002621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324002622	ATP binding site [chemical binding]; other site
224324002623	putative Mg++ binding site [ion binding]; other site
224324002624	TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361
224324002625	active site
224324002626	putative interdomain interaction site [polypeptide binding]; other site
224324002627	putative metal-binding site [ion binding]; other site
224324002628	putative nucleotide binding site [chemical binding]; other site
224324002629	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
224324002630	domain I; other site
224324002631	DNA binding groove [nucleotide binding]
224324002632	phosphate binding site [ion binding]; other site
224324002633	domain II; other site
224324002634	domain III; other site
224324002635	nucleotide binding site [chemical binding]; other site
224324002636	catalytic site [active]
224324002637	domain IV; other site
224324002638	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
224324002639	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
224324002640	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
224324002641	dimer interface [polypeptide binding]; other site
224324002642	PYR/PP interface [polypeptide binding]; other site
224324002643	TPP binding site [chemical binding]; other site
224324002644	substrate binding site [chemical binding]; other site
224324002645	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224324002646	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
224324002647	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
224324002648	TPP-binding site [chemical binding]; other site
224324002649	dimer interface [polypeptide binding]; other site
224324002650	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
224324002651	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
224324002652	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224324002653	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
224324002654	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224324002655	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
224324002656	IMP binding site; other site
224324002657	dimer interface [polypeptide binding]; other site
224324002658	interdomain contacts; other site
224324002659	partial ornithine binding site; other site
224324002660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224324002661	catalytic core [active]
224324002662	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
224324002663	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
224324002664	amidophosphoribosyltransferase; Region: purF; TIGR01134
224324002665	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
224324002666	active site
224324002667	tetramer interface [polypeptide binding]; other site
224324002668	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324002669	active site
224324002670	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
224324002671	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
224324002672	active site
224324002673	homodimer interface [polypeptide binding]; other site
224324002674	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
224324002675	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
224324002676	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
224324002677	homotetramer interface [polypeptide binding]; other site
224324002678	ligand binding site [chemical binding]; other site
224324002679	catalytic site [active]
224324002680	NAD binding site [chemical binding]; other site
224324002681	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
224324002682	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
224324002683	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
224324002684	Flagellar hook-basal body protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliE; COG1677
224324002685	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
224324002686	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224324002687	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224324002688	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
224324002689	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
224324002690	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
224324002691	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
224324002692	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
224324002693	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
224324002694	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
224324002695	DNA protecting protein DprA; Region: dprA; TIGR00732
224324002696	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
224324002697	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
224324002698	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
224324002699	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
224324002700	putative active site [active]
224324002701	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
224324002702	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
224324002703	dimer interface [polypeptide binding]; other site
224324002704	PYR/PP interface [polypeptide binding]; other site
224324002705	TPP binding site [chemical binding]; other site
224324002706	substrate binding site [chemical binding]; other site
224324002707	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224324002708	Thiamine pyrophosphate (TPP family), Pyruvate ferredoxin/flavodoxin oxidoreductase (PFOR) subfamily, TPP-binding module; PFOR catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA, a crucial step in many metabolic pathways. Archaea; Region: TPP_PFOR; cd02018
224324002709	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
224324002710	TPP-binding site [chemical binding]; other site
224324002711	dimer interface [polypeptide binding]; other site
224324002712	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
224324002713	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
224324002714	ZPR1 zinc-finger domain; Region: zf-ZPR1; cl19251
224324002715	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
224324002716	dimer interface [polypeptide binding]; other site
224324002717	putative anticodon binding site; other site
224324002718	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
224324002719	motif 1; other site
224324002720	active site
224324002721	motif 2; other site
224324002722	motif 3; other site
224324002723	ThiC family; Region: ThiC; pfam01964
224324002724	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
224324002725	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224324002726	metal binding site 2 [ion binding]; metal-binding site
224324002727	putative DNA binding helix; other site
224324002728	metal binding site 1 [ion binding]; metal-binding site
224324002729	dimer interface [polypeptide binding]; other site
224324002730	structural Zn2+ binding site [ion binding]; other site
224324002731	diaminopimelate decarboxylase; Region: lysA; TIGR01048
224324002732	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
224324002733	active site
224324002734	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224324002735	substrate binding site [chemical binding]; other site
224324002736	catalytic residues [active]
224324002737	dimer interface [polypeptide binding]; other site
224324002738	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
224324002739	PilZ domain; Region: PilZ; pfam07238
224324002740	flagellar biosynthesis protein FlhA; Region: FlhA; TIGR01398
224324002741	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
224324002742	SRP54-type protein, GTPase domain; Region: SRP54; pfam00448
224324002743	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
224324002744	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
224324002745	P-loop; other site
224324002746	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
224324002747	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224324002748	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224324002749	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224324002750	DNA binding residues [nucleotide binding]
224324002751	Transcriptional repressor TCF25; Region: Tcf25; pfam04910
224324002752	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224324002753	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; pfam02366
224324002754	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224324002755	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
224324002756	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
224324002757	active site
224324002758	HIGH motif; other site
224324002759	KMSKS motif; other site
224324002760	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
224324002761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224324002762	Walker A/P-loop; other site
224324002763	ATP binding site [chemical binding]; other site
224324002764	Q-loop/lid; other site
224324002765	ABC transporter signature motif; other site
224324002766	Walker B; other site
224324002767	D-loop; other site
224324002768	H-loop/switch region; other site
224324002769	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
224324002770	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
224324002771	Putative zinc ribbon domain; Region: DUF164; pfam02591
224324002772	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
224324002773	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
224324002774	Ligand Binding Site [chemical binding]; other site
224324002775	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
224324002776	Major Facilitator Superfamily; Region: MFS_1; pfam07690
224324002777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224324002778	putative substrate translocation pore; other site
224324002779	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
224324002780	Polymerase and Histidinol Phosphatase domain of Thermotoga like; Region: PHP_HisPPase_Thermotoga_like; cd12111
224324002781	active site
224324002782	dimer interface [polypeptide binding]; other site
224324002783	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
224324002784	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
224324002785	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
224324002786	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
224324002787	The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763
224324002788	putative [Fe4-S4] binding site [ion binding]; other site
224324002789	putative molybdopterin cofactor binding site [chemical binding]; other site
224324002790	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
224324002791	putative molybdopterin cofactor binding site; other site
224324002792	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224324002793	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
224324002794	precorrin-2 dehydrogenase; Validated; Region: PRK06719
224324002795	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
224324002796	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
224324002797	Mitochondrial ribosome subunit S24; Region: MRP-S24; pfam14955
224324002798	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
224324002799	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
224324002800	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
224324002801	short chain dehydrogenase; Region: adh_short; pfam00106
224324002802	NADP binding site [chemical binding]; other site
224324002803	homodimer interface [polypeptide binding]; other site
224324002804	active site
224324002805	MutS2 family protein; Region: mutS2; TIGR01069
224324002806	MutS domain III; Region: MutS_III; pfam05192
224324002807	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
224324002808	Walker A/P-loop; other site
224324002809	ATP binding site [chemical binding]; other site
224324002810	Q-loop/lid; other site
224324002811	ABC transporter signature motif; other site
224324002812	Walker B; other site
224324002813	D-loop; other site
224324002814	H-loop/switch region; other site
224324002815	Smr domain; Region: Smr; pfam01713
224324002816	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
224324002817	ketol-acid reductoisomerase; Provisional; Region: PRK05479
224324002818	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
224324002819	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
224324002820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
224324002821	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
224324002822	Tetratricopeptide repeat; Region: TPR_6; pfam13174
224324002823	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
224324002824	active site
224324002825	dimer interface [polypeptide binding]; other site
224324002826	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
224324002827	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
224324002828	substrate binding site [chemical binding]; other site
224324002829	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
224324002830	preprotein translocase, YajC subunit; Region: yajC; TIGR00739
224324002831	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
224324002832	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
224324002833	G1 box; other site
224324002834	GTP/Mg2+ binding site [chemical binding]; other site
224324002835	Switch I region; other site
224324002836	G2 box; other site
224324002837	G3 box; other site
224324002838	Switch II region; other site
224324002839	G4 box; other site
224324002840	G5 box; other site
224324002841	Nucleoside recognition; Region: Gate; pfam07670
224324002842	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
224324002843	Nucleoside recognition; Region: Gate; pfam07670
224324002844	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
224324002845	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
224324002846	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
224324002847	active site
224324002848	HIGH motif; other site
224324002849	KMSKS motif; other site
224324002850	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
224324002851	tRNA binding surface [nucleotide binding]; other site
224324002852	anticodon binding site; other site
224324002853	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
224324002854	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
224324002855	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890
224324002856	FMN-binding domain; Region: FMN_bind; pfam04205
224324002857	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
224324002858	Carbon starvation protein CstA; Region: CstA; pfam02554
224324002859	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
224324002860	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
224324002861	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
224324002862	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
224324002863	Sulfate transporter family; Region: Sulfate_transp; pfam00916
224324002864	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
224324002865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324002866	S-adenosylmethionine binding site [chemical binding]; other site
224324002867	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224324002868	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224324002869	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224324002870	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
224324002871	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
224324002872	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
224324002873	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224324002874	RNA binding site [nucleotide binding]; other site
224324002875	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
224324002876	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
224324002877	glutamyl-tRNA reductase; Region: hemA; TIGR01035
224324002878	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
224324002879	tRNA; other site
224324002880	putative tRNA binding site [nucleotide binding]; other site
224324002881	putative NADP binding site [chemical binding]; other site
224324002882	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
224324002883	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
224324002884	hinge; other site
224324002885	active site
224324002886	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
224324002887	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
224324002888	putative dimer interface [polypeptide binding]; other site
224324002889	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
224324002890	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224324002891	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
224324002892	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
224324002893	type II secretion system protein D; Region: type_II_gspD; TIGR02517
224324002894	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
224324002895	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
224324002896	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
224324002897	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
224324002898	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
224324002899	GDP-binding site [chemical binding]; other site
224324002900	ACT binding site; other site
224324002901	IMP binding site; other site
224324002902	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
224324002903	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324002904	Walker A motif; other site
224324002905	ATP binding site [chemical binding]; other site
224324002906	Walker B motif; other site
224324002907	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
224324002908	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
224324002909	motif 1; other site
224324002910	active site
224324002911	motif 2; other site
224324002912	motif 3; other site
224324002913	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224324002914	DHHA1 domain; Region: DHHA1; pfam02272
224324002915	reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612
224324002916	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
224324002917	Clp amino terminal domain; Region: Clp_N; pfam02861
224324002918	Clp amino terminal domain; Region: Clp_N; pfam02861
224324002919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324002920	Walker A motif; other site
224324002921	ATP binding site [chemical binding]; other site
224324002922	Walker B motif; other site
224324002923	arginine finger; other site
224324002924	UvrB/uvrC motif; Region: UVR; pfam02151
224324002925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324002926	Walker A motif; other site
224324002927	ATP binding site [chemical binding]; other site
224324002928	Walker B motif; other site
224324002929	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224324002930	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
224324002931	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324002932	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324002933	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324002934	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324002935	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
224324002936	Surface antigen; Region: Bac_surface_Ag; pfam01103
224324002937	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
224324002938	DNA-binding site [nucleotide binding]; DNA binding site
224324002939	RNA-binding motif; other site
224324002940	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
224324002941	catalytic residues [active]
224324002942	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
224324002943	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
224324002944	FAD binding pocket [chemical binding]; other site
224324002945	FAD binding motif [chemical binding]; other site
224324002946	phosphate binding motif [ion binding]; other site
224324002947	beta-alpha-beta structure motif; other site
224324002948	NAD binding pocket [chemical binding]; other site
224324002949	Iron coordination center [ion binding]; other site
224324002950	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
224324002951	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
224324002952	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
224324002953	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
224324002954	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
224324002955	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
224324002956	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
224324002957	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
224324002958	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
224324002959	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
224324002960	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
224324002961	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
224324002962	NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005
224324002963	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
224324002964	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324002965	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
224324002966	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
224324002967	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713
224324002968	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
224324002969	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
224324002970	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324002971	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
224324002972	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324002973	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
224324002974	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324002975	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
224324002976	substrate binding site; other site
224324002977	dimer interface; other site
224324002978	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
224324002979	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
224324002980	Superfamily II helicase [General function prediction only]; Region: COG1204
224324002981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324002982	ATP binding site [chemical binding]; other site
224324002983	putative Mg++ binding site [ion binding]; other site
224324002984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224324002985	nucleotide binding region [chemical binding]; other site
224324002986	ATP-binding site [chemical binding]; other site
224324002987	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
224324002988	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
224324002989	ATP binding site [chemical binding]; other site
224324002990	substrate interface [chemical binding]; other site
224324002991	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
224324002992	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
224324002993	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
224324002994	Protein of unknown function (DUF342); Region: DUF342; cl19219
224324002995	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324002996	putative membrane fusion protein; Region: TIGR02828
224324002997	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
224324002998	Outer membrane efflux protein; Region: OEP; pfam02321
224324002999	Outer membrane efflux protein; Region: OEP; pfam02321
224324003000	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
224324003001	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
224324003002	Ligand Binding Site [chemical binding]; other site
224324003003	TIGR00269 family protein; Region: TIGR00269
224324003004	CTP synthetase; Validated; Region: pyrG; PRK05380
224324003005	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
224324003006	Catalytic site [active]
224324003007	active site
224324003008	UTP binding site [chemical binding]; other site
224324003009	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
224324003010	active site
224324003011	putative oxyanion hole; other site
224324003012	catalytic triad [active]
224324003013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
224324003014	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
224324003015	putative NAD(P) binding site [chemical binding]; other site
224324003016	active site
224324003017	putative substrate binding site [chemical binding]; other site
224324003018	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
224324003019	putative ligand binding pocket/active site [active]
224324003020	putative metal binding site [ion binding]; other site
224324003021	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
224324003022	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
224324003023	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324003024	Walker A motif; other site
224324003025	ATP binding site [chemical binding]; other site
224324003026	Walker B motif; other site
224324003027	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224324003028	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
224324003029	oligomer interface [polypeptide binding]; other site
224324003030	active site residues [active]
224324003031	trigger factor; Region: tig; TIGR00115
224324003032	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
224324003033	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
224324003034	phosphoglycolate phosphatase; Provisional; Region: PRK13222
224324003035	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324003036	active site
224324003037	motif I; other site
224324003038	motif II; other site
224324003039	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
224324003040	catalytic residues [active]
224324003041	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
224324003042	PspA/IM30 family; Region: PspA_IM30; pfam04012
224324003043	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
224324003044	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
224324003045	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
224324003046	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
224324003047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324003048	S-adenosylmethionine binding site [chemical binding]; other site
224324003049	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
224324003050	PhoH-like protein; Region: PhoH; pfam02562
224324003051	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
224324003052	lipoyl synthase; Provisional; Region: PRK12928
224324003053	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324003054	FeS/SAM binding site; other site
224324003055	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
224324003056	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
224324003057	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
224324003058	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
224324003059	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224324003060	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224324003061	Coenzyme A binding pocket [chemical binding]; other site
224324003062	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224324003063	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
224324003064	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224324003065	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224324003066	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
224324003067	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
224324003068	putative NAD(P) binding site [chemical binding]; other site
224324003069	structural Zn binding site [ion binding]; other site
224324003070	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
224324003071	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224324003072	carboxyltransferase (CT) interaction site; other site
224324003073	biotinylation site [posttranslational modification]; other site
224324003074	elongation factor P; Validated; Region: PRK00529
224324003075	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
224324003076	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
224324003077	RNA binding site [nucleotide binding]; other site
224324003078	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
224324003079	RNA binding site [nucleotide binding]; other site
224324003080	Uncharacterized conserved protein [Function unknown]; Region: COG0062
224324003081	putative carbohydrate kinase; Provisional; Region: PRK10565
224324003082	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
224324003083	putative substrate binding site [chemical binding]; other site
224324003084	putative ATP binding site [chemical binding]; other site
224324003085	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
224324003086	thiamine phosphate binding site [chemical binding]; other site
224324003087	active site
224324003088	pyrophosphate binding site [ion binding]; other site
224324003089	Predicted sugar nucleotidyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1213
224324003090	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
224324003091	active site
224324003092	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
224324003093	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
224324003094	active site
224324003095	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
224324003096	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
224324003097	argininosuccinate lyase; Region: argH; TIGR00838
224324003098	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
224324003099	active sites [active]
224324003100	tetramer interface [polypeptide binding]; other site
224324003101	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
224324003102	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
224324003103	4Fe-4S binding domain; Region: Fer4; pfam00037
224324003104	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
224324003105	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; Region: NuoK; COG0713
224324003106	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
224324003107	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
224324003108	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324003109	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
224324003110	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324003111	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
224324003112	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
224324003113	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
224324003114	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
224324003115	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
224324003116	active site
224324003117	nucleophile elbow; other site
224324003118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224324003119	dimerization interface [polypeptide binding]; other site
224324003120	putative DNA binding site [nucleotide binding]; other site
224324003121	putative Zn2+ binding site [ion binding]; other site
224324003122	Predicted permease; Region: DUF318; pfam03773
224324003123	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
224324003124	intersubunit interface [polypeptide binding]; other site
224324003125	active site
224324003126	zinc binding site [ion binding]; other site
224324003127	Na+ binding site [ion binding]; other site
224324003128	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
224324003129	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
224324003130	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
224324003131	ATP-dependent DNA ligase; Provisional; Region: PRK01109
224324003132	DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675
224324003133	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
224324003134	active site
224324003135	DNA binding site [nucleotide binding]
224324003136	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_I; cd07969
224324003137	DNA binding site [nucleotide binding]
224324003138	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
224324003139	substrate binding site [chemical binding]; other site
224324003140	cellulose synthase regulator protein; Provisional; Region: PRK11114
224324003141	Endoglucanase Y [Carbohydrate transport and metabolism]; Region: CelA; COG3405
224324003142	Tetratricopeptide repeat; Region: TPR_16; pfam13432
224324003143	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324003144	TPR motif; other site
224324003145	binding surface
224324003146	Tetratricopeptide repeat; Region: TPR_19; pfam14559
224324003147	TPR repeat; Region: TPR_11; pfam13414
224324003148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324003149	binding surface
224324003150	TPR motif; other site
224324003151	TPR repeat; Region: TPR_11; pfam13414
224324003152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324003153	binding surface
224324003154	TPR motif; other site
224324003155	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
224324003156	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
224324003157	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224324003158	P-loop; other site
224324003159	Magnesium ion binding site [ion binding]; other site
224324003160	Sporulation related domain; Region: SPOR; pfam05036
224324003161	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
224324003162	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
224324003163	DXD motif; other site
224324003164	PilZ domain; Region: PilZ; pfam07238
224324003165	Uncharacterized conserved protein [Function unknown]; Region: COG1801
224324003166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324003167	TPR motif; other site
224324003168	TPR repeat; Region: TPR_11; pfam13414
224324003169	binding surface
224324003170	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
224324003171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324003172	catalytic residue [active]
224324003173	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
224324003174	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
224324003175	active site
224324003176	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
224324003177	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
224324003178	active site
224324003179	HIGH motif; other site
224324003180	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
224324003181	KMSKS motif; other site
224324003182	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
224324003183	tRNA binding surface [nucleotide binding]; other site
224324003184	anticodon binding site; other site
224324003185	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
224324003186	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
224324003187	metal binding site 2 [ion binding]; metal-binding site
224324003188	putative DNA binding helix; other site
224324003189	metal binding site 1 [ion binding]; metal-binding site
224324003190	dimer interface [polypeptide binding]; other site
224324003191	structural Zn2+ binding site [ion binding]; other site
224324003192	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
224324003193	GTP binding site; other site
224324003194	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224324003195	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224324003196	catalytic residue [active]
224324003197	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: SirA; COG0425
224324003198	CPxP  motif; other site
224324003199	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
224324003200	hypothetical protein; Provisional; Region: PRK08609
224324003201	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
224324003202	active site
224324003203	primer binding site [nucleotide binding]; other site
224324003204	NTP  binding site [chemical binding]; other site
224324003205	metal binding triad [ion binding]; metal-binding site
224324003206	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
224324003207	active site
224324003208	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
224324003209	active site
224324003210	hydrophilic channel; other site
224324003211	dimerization interface [polypeptide binding]; other site
224324003212	catalytic residues [active]
224324003213	active site lid [active]
224324003214	coproporphyrinogen III oxidase; Provisional; Region: PRK08446
224324003215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324003216	FeS/SAM binding site; other site
224324003217	HemN C-terminal domain; Region: HemN_C; pfam06969
224324003218	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
224324003219	Lipid-A-disaccharide synthetase; Region: LpxB; pfam02684
224324003220	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
224324003221	FAD binding site [chemical binding]; other site
224324003222	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
224324003223	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
224324003224	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
224324003225	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
224324003226	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
224324003227	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
224324003228	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
224324003229	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
224324003230	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
224324003231	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
224324003232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324003233	PAS domain; Region: PAS_9; pfam13426
224324003234	putative active site [active]
224324003235	heme pocket [chemical binding]; other site
224324003236	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
224324003237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
224324003238	PAS domain; Region: PAS_9; pfam13426
224324003239	putative active site [active]
224324003240	heme pocket [chemical binding]; other site
224324003241	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324003242	metal binding site [ion binding]; metal-binding site
224324003243	active site
224324003244	I-site; other site
224324003245	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
224324003246	Uncharacterized conserved protein [Function unknown]; Region: AMMECR1; COG2078
224324003247	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
224324003248	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224324003249	metal-binding site [ion binding]
224324003250	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
224324003251	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
224324003252	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324003253	motif II; other site
224324003254	Haemagglutinin; Region: Hemagglutinin; pfam00509
224324003255	Argonaute homolog, implicated in RNA metabolism [Translation, ribosomal structure and biogenesis]; Region: COG1431
224324003256	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
224324003257	5' RNA guide strand anchoring site; other site
224324003258	active site
224324003259	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
224324003260	nudix motif; other site
224324003261	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
224324003262	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
224324003263	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224324003264	protein binding site [polypeptide binding]; other site
224324003265	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224324003266	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224324003267	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
224324003268	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224324003269	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224324003270	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224324003271	DNA binding residues [nucleotide binding]
224324003272	FIST N domain; Region: FIST; cl10701
224324003273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
224324003274	metal binding site [ion binding]; metal-binding site
224324003275	active site
224324003276	I-site; other site
224324003277	Methyltransferase domain; Region: Methyltransf_31; pfam13847
224324003278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324003279	S-adenosylmethionine binding site [chemical binding]; other site
224324003280	Probable transposase; Region: OrfB_IS605; pfam01385
224324003281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
224324003282	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
224324003283	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
224324003284	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
224324003285	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324003286	RNA binding surface [nucleotide binding]; other site
224324003287	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
224324003288	active site
224324003289	Uncharacterized conserved protein [Function unknown]; Region: COG1624
224324003290	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
224324003291	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
224324003292	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
224324003293	substrate binding pocket [chemical binding]; other site
224324003294	dimer interface [polypeptide binding]; other site
224324003295	inhibitor binding site; inhibition site
224324003296	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
224324003297	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
224324003298	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224324003299	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224324003300	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
224324003301	replicative DNA helicase; Region: DnaB; TIGR00665
224324003302	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
224324003303	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
224324003304	Walker A motif; other site
224324003305	ATP binding site [chemical binding]; other site
224324003306	Walker B motif; other site
224324003307	DNA binding loops [nucleotide binding]
224324003308	Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031
224324003309	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
224324003310	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
224324003311	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
224324003312	Walker A motif; other site
224324003313	ATP binding site [chemical binding]; other site
224324003314	Walker B motif; other site
224324003315	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
224324003316	Uncharacterized iron-regulated protein [Function unknown]; Region: PhuW; COG3016
224324003317	recombination protein RecR; Region: recR; TIGR00615
224324003318	RecR protein; Region: RecR; pfam02132
224324003319	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
224324003320	putative active site [active]
224324003321	putative metal-binding site [ion binding]; other site
224324003322	tetramer interface [polypeptide binding]; other site
224324003323	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
224324003324	Predicted membrane protein [Function unknown]; Region: COG4711
224324003325	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
224324003326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
224324003327	Coenzyme A binding pocket [chemical binding]; other site
224324003328	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
224324003329	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
224324003330	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
224324003331	AAA domain; Region: AAA_33; pfam13671
224324003332	ATP-binding site [chemical binding]; other site
224324003333	Gluconate-6-phosphate binding site [chemical binding]; other site
224324003334	Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776
224324003335	DNA binding site [nucleotide binding]
224324003336	dimer interface [polypeptide binding]; other site
224324003337	ribosomal protein S1; Region: rpsA; TIGR00717
224324003338	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
224324003339	RNA binding site [nucleotide binding]; other site
224324003340	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
224324003341	RNA binding site [nucleotide binding]; other site
224324003342	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
224324003343	RNA binding site [nucleotide binding]; other site
224324003344	S1 RNA binding domain; Region: S1; pfam00575
224324003345	RNA binding site [nucleotide binding]; other site
224324003346	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
224324003347	RNA binding site [nucleotide binding]; other site
224324003348	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
224324003349	RNA binding site [nucleotide binding]; other site
224324003350	tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336
224324003351	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
224324003352	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
224324003353	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
224324003354	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
224324003355	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
224324003356	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
224324003357	DNA binding residues [nucleotide binding]
224324003358	CHC2 zinc finger; Region: zf-CHC2; cl17510
224324003359	DNA primase, catalytic core; Region: dnaG; TIGR01391
224324003360	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
224324003361	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
224324003362	active site
224324003363	metal binding site [ion binding]; metal-binding site
224324003364	interdomain interaction site; other site
224324003365	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
224324003366	active site
224324003367	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
224324003368	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
224324003369	active site
224324003370	DNA binding site [nucleotide binding]
224324003371	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
224324003372	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
224324003373	nucleotide binding site [chemical binding]; other site
224324003374	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
224324003375	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
224324003376	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
224324003377	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
224324003378	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
224324003379	O-Antigen ligase; Region: Wzy_C; pfam04932
224324003380	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224324003381	TrkA-N domain; Region: TrkA_N; pfam02254
224324003382	TrkA-C domain; Region: TrkA_C; pfam02080
224324003383	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
224324003384	Cation transport protein; Region: TrkH; cl17365
224324003385	Cation transport protein; Region: TrkH; pfam02386
224324003386	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
224324003387	dimer interface [polypeptide binding]; other site
224324003388	putative radical transfer pathway; other site
224324003389	diiron center [ion binding]; other site
224324003390	tyrosyl radical; other site
224324003391	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
224324003392	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
224324003393	protein-splicing catalytic site; other site
224324003394	thioester formation/cholesterol transfer; other site
224324003395	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
224324003396	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
224324003397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324003398	S-adenosylmethionine binding site [chemical binding]; other site
224324003399	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
224324003400	Protein of unknown function DUF58; Region: DUF58; pfam01882
224324003401	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
224324003402	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
224324003403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224324003404	dimer interface [polypeptide binding]; other site
224324003405	conserved gate region; other site
224324003406	putative PBP binding loops; other site
224324003407	ABC-ATPase subunit interface; other site
224324003408	Transcriptional regulator [Transcription]; Region: IclR; COG1414
224324003409	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224324003410	putative DNA binding site [nucleotide binding]; other site
224324003411	putative Zn2+ binding site [ion binding]; other site
224324003412	Bacterial transcriptional regulator; Region: IclR; pfam01614
224324003413	Isocitrate dehydrogenases [Energy production and conversion]; Region: Icd; COG0538
224324003414	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
224324003415	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
224324003416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224324003417	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224324003418	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
224324003419	pyruvate carboxylase subunit B; Validated; Region: PRK09282
224324003420	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
224324003421	active site
224324003422	catalytic residues [active]
224324003423	metal binding site [ion binding]; metal-binding site
224324003424	homodimer binding site [polypeptide binding]; other site
224324003425	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
224324003426	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224324003427	carboxyltransferase (CT) interaction site; other site
224324003428	biotinylation site [posttranslational modification]; other site
224324003429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324003430	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
224324003431	Walker A motif; other site
224324003432	ATP binding site [chemical binding]; other site
224324003433	Walker B motif; other site
224324003434	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
224324003435	arginine finger; other site
224324003436	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
224324003437	Radical SAM superfamily; Region: Radical_SAM; pfam04055
224324003438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324003439	FeS/SAM binding site; other site
224324003440	conserved hypothetical integral membrane protein; Region: TIGR00056
224324003441	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
224324003442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224324003443	Walker A/P-loop; other site
224324003444	ATP binding site [chemical binding]; other site
224324003445	Q-loop/lid; other site
224324003446	ABC transporter signature motif; other site
224324003447	Walker B; other site
224324003448	D-loop; other site
224324003449	H-loop/switch region; other site
224324003450	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
224324003451	mce related protein; Region: MCE; pfam02470
224324003452	Guanylate-binding protein, N-terminal domain; Region: GBP; cl19296
224324003453	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
224324003454	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
224324003455	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
224324003456	active site
224324003457	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
224324003458	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
224324003459	hinge; other site
224324003460	active site
224324003461	flagellar motor switch protein FliN; Region: fliN; TIGR02480
224324003462	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
224324003463	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
224324003464	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
224324003465	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
224324003466	putative active site [active]
224324003467	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
224324003468	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
224324003469	putative active site [active]
224324003470	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
224324003471	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
224324003472	dimer interface [polypeptide binding]; other site
224324003473	substrate binding site [chemical binding]; other site
224324003474	metal binding sites [ion binding]; metal-binding site
224324003475	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
224324003476	substrate binding site [chemical binding]; other site
224324003477	active site
224324003478	catalytic residues [active]
224324003479	heterodimer interface [polypeptide binding]; other site
224324003480	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
224324003481	Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654
224324003482	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
224324003483	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
224324003484	NAD binding site [chemical binding]; other site
224324003485	homotetramer interface [polypeptide binding]; other site
224324003486	homodimer interface [polypeptide binding]; other site
224324003487	substrate binding site [chemical binding]; other site
224324003488	active site
224324003489	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
224324003490	putative active site; other site
224324003491	catalytic residue [active]
224324003492	cysteine synthase; Region: PLN02565
224324003493	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
224324003494	dimer interface [polypeptide binding]; other site
224324003495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324003496	catalytic residue [active]
224324003497	Tetratricopeptide repeat; Region: TPR_19; pfam14559
224324003498	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
224324003499	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
224324003500	G1 box; other site
224324003501	GTP/Mg2+ binding site [chemical binding]; other site
224324003502	G2 box; other site
224324003503	Switch I region; other site
224324003504	G3 box; other site
224324003505	Switch II region; other site
224324003506	G4 box; other site
224324003507	G5 box; other site
224324003508	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
224324003509	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
224324003510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224324003511	Walker A/P-loop; other site
224324003512	ATP binding site [chemical binding]; other site
224324003513	Q-loop/lid; other site
224324003514	ABC transporter signature motif; other site
224324003515	Walker B; other site
224324003516	D-loop; other site
224324003517	H-loop/switch region; other site
224324003518	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
224324003519	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
224324003520	active site
224324003521	dimer interface [polypeptide binding]; other site
224324003522	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
224324003523	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
224324003524	active site
224324003525	FMN binding site [chemical binding]; other site
224324003526	substrate binding site [chemical binding]; other site
224324003527	3Fe-4S cluster binding site [ion binding]; other site
224324003528	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
224324003529	domain interface; other site
224324003530	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
224324003531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
224324003532	putative substrate translocation pore; other site
224324003533	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
224324003534	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
224324003535	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224324003536	Uncharacterized conserved protein [Function unknown]; Region: COG1507
224324003537	hypothetical protein; Validated; Region: PRK00110
224324003538	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
224324003539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
224324003540	ATP binding site [chemical binding]; other site
224324003541	Mg2+ binding site [ion binding]; other site
224324003542	G-X-G motif; other site
224324003543	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
224324003544	ATP binding site [chemical binding]; other site
224324003545	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
224324003546	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224324003547	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224324003548	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224324003549	catalytic residue [active]
224324003550	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
224324003551	active site
224324003552	dimer interface [polypeptide binding]; other site
224324003553	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
224324003554	PilZ domain; Region: PilZ; pfam07238
224324003555	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
224324003556	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
224324003557	FtsX-like permease family; Region: FtsX; pfam02687
224324003558	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
224324003559	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
224324003560	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
224324003561	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
224324003562	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
224324003563	Nucleoside diphosphate kinase; Region: NDK; pfam00334
224324003564	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
224324003565	active site
224324003566	multimer interface [polypeptide binding]; other site
224324003567	ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026
224324003568	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224324003569	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
224324003570	Walker A motif/ATP binding site; other site
224324003571	Walker B motif; other site
224324003572	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
224324003573	Flagellar assembly protein FliH; Region: FliH; cl19405
224324003574	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
224324003575	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
224324003576	FMN binding site [chemical binding]; other site
224324003577	active site
224324003578	catalytic residues [active]
224324003579	substrate binding site [chemical binding]; other site
224324003580	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
224324003581	active site residue [active]
224324003582	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
224324003583	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
224324003584	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
224324003585	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
224324003586	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
224324003587	Protein export membrane protein; Region: SecD_SecF; pfam02355
224324003588	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
224324003589	30S subunit binding site; other site
224324003590	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
224324003591	homodimer interface [polypeptide binding]; other site
224324003592	substrate-cofactor binding pocket; other site
224324003593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324003594	catalytic residue [active]
224324003595	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
224324003596	trimer interface [polypeptide binding]; other site
224324003597	active site
224324003598	molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256
224324003599	DNA repair protein radc; Region: radc; TIGR00608
224324003600	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
224324003601	MPN+ (JAMM) motif; other site
224324003602	Zinc-binding site [ion binding]; other site
224324003603	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
224324003604	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
224324003605	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
224324003606	pyruvate carboxylase subunit B; Validated; Region: PRK09282
224324003607	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
224324003608	active site
224324003609	catalytic residues [active]
224324003610	metal binding site [ion binding]; metal-binding site
224324003611	homodimer binding site [polypeptide binding]; other site
224324003612	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
224324003613	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
224324003614	carboxyltransferase (CT) interaction site; other site
224324003615	biotinylation site [posttranslational modification]; other site
224324003616	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
224324003617	Competence protein; Region: Competence; pfam03772
224324003618	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
224324003619	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
224324003620	CoA-ligase; Region: Ligase_CoA; pfam00549
224324003621	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
224324003622	CoA binding domain; Region: CoA_binding; pfam02629
224324003623	CoA-ligase; Region: Ligase_CoA; pfam00549
224324003624	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
224324003625	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
224324003626	5'-3' exonuclease; Region: 53EXOc; smart00475
224324003627	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
224324003628	active site
224324003629	metal binding site 1 [ion binding]; metal-binding site
224324003630	putative 5' ssDNA interaction site; other site
224324003631	metal binding site 3; metal-binding site
224324003632	metal binding site 2 [ion binding]; metal-binding site
224324003633	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
224324003634	putative DNA binding site [nucleotide binding]; other site
224324003635	putative metal binding site [ion binding]; other site
224324003636	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
224324003637	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
224324003638	AP (apurinic/apyrimidinic) site pocket; other site
224324003639	DNA interaction; other site
224324003640	Metal-binding active site; metal-binding site
224324003641	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
224324003642	DHH family; Region: DHH; pfam01368
224324003643	DHHA1 domain; Region: DHHA1; pfam02272
224324003644	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
224324003645	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324003646	FeS/SAM binding site; other site
224324003647	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
224324003648	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
224324003649	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
224324003650	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
224324003651	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
224324003652	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324003653	active site
224324003654	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224324003655	Protein of unknown function DUF116; Region: DUF116; pfam01976
224324003656	CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; pfam02552
224324003657	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
224324003658	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
224324003659	Cysteine-rich domain; Region: CCG; pfam02754
224324003660	Cysteine-rich domain; Region: CCG; pfam02754
224324003661	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
224324003662	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
224324003663	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324003664	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
224324003665	putative ADP-binding pocket [chemical binding]; other site
224324003666	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
224324003667	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
224324003668	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
224324003669	23S rRNA binding site [nucleotide binding]; other site
224324003670	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
224324003671	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
224324003672	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
224324003673	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
224324003674	23S rRNA interface [nucleotide binding]; other site
224324003675	L21e interface [polypeptide binding]; other site
224324003676	5S rRNA interface [nucleotide binding]; other site
224324003677	L27 interface [polypeptide binding]; other site
224324003678	L5 interface [polypeptide binding]; other site
224324003679	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
224324003680	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224324003681	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
224324003682	Ribosomal protein S8; Region: Ribosomal_S8; pfam00410
224324003683	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
224324003684	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
224324003685	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
224324003686	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
224324003687	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
224324003688	RNA binding site [nucleotide binding]; other site
224324003689	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
224324003690	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
224324003691	V4R domain; Region: V4R; pfam02830
224324003692	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
224324003693	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
224324003694	lipoyl attachment site [posttranslational modification]; other site
224324003695	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
224324003696	active site
224324003697	intersubunit interface [polypeptide binding]; other site
224324003698	Zn2+ binding site [ion binding]; other site
224324003699	6-carboxyhexanoate--CoA ligase; Region: bioW; TIGR01204
224324003700	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
224324003701	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
224324003702	trimer interface [polypeptide binding]; other site
224324003703	putative metal binding site [ion binding]; other site
224324003704	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
224324003705	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
224324003706	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
224324003707	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
224324003708	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
224324003709	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224324003710	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
224324003711	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224324003712	ATP-grasp domain; Region: ATP-grasp_4; cl17255
224324003713	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
224324003714	malate dehydrogenase; Reviewed; Region: PRK06223
224324003715	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
224324003716	NAD(P) binding site [chemical binding]; other site
224324003717	dimer interface [polypeptide binding]; other site
224324003718	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224324003719	substrate binding site [chemical binding]; other site
224324003720	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
224324003721	putative active site [active]
224324003722	putative metal binding site [ion binding]; other site
224324003723	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
224324003724	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
224324003725	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
224324003726	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
224324003727	active site
224324003728	dimer interface [polypeptide binding]; other site
224324003729	motif 1; other site
224324003730	motif 2; other site
224324003731	motif 3; other site
224324003732	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
224324003733	anticodon binding site; other site
224324003734	Protein of unknown function DUF86; Region: DUF86; cl01031
224324003735	Uncharacterized conserved protein [Function unknown]; Region: COG2445
224324003736	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
224324003737	catalytic residues [active]
224324003738	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
224324003739	Outer membrane efflux protein; Region: OEP; pfam02321
224324003740	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
224324003741	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
224324003742	active site
224324003743	HslU subunit interaction site [polypeptide binding]; other site
224324003744	Clp amino terminal domain; Region: Clp_N; pfam02861
224324003745	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
224324003746	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324003747	Walker A motif; other site
224324003748	ATP binding site [chemical binding]; other site
224324003749	Walker B motif; other site
224324003750	arginine finger; other site
224324003751	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
224324003752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324003753	Walker A motif; other site
224324003754	ATP binding site [chemical binding]; other site
224324003755	Walker B motif; other site
224324003756	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
224324003757	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
224324003758	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
224324003759	dimer interface [polypeptide binding]; other site
224324003760	anticodon binding site; other site
224324003761	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
224324003762	homodimer interface [polypeptide binding]; other site
224324003763	motif 1; other site
224324003764	active site
224324003765	motif 2; other site
224324003766	GAD domain; Region: GAD; pfam02938
224324003767	motif 3; other site
224324003768	Fumarase C-terminus; Region: Fumerase_C; cl00795
224324003769	Uncharacterized conserved protein [Function unknown]; Region: COG3334
224324003770	AMIN domain; Region: AMIN; pfam11741
224324003771	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
224324003772	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
224324003773	active site
224324003774	metal binding site [ion binding]; metal-binding site
224324003775	HerA helicase [Replication, recombination, and repair]; Region: COG0433
224324003776	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
224324003777	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
224324003778	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
224324003779	active site
224324003780	Right handed beta helix region; Region: Beta_helix; pfam13229
224324003781	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
224324003782	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
224324003783	HlyD family secretion protein; Region: HlyD_3; pfam13437
224324003784	Sporulation related domain; Region: SPOR; pfam05036
224324003785	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
224324003786	MPN+ (JAMM) motif; other site
224324003787	Zinc-binding site [ion binding]; other site
224324003788	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
224324003789	Fe-S cluster binding site [ion binding]; other site
224324003790	active site
224324003791	SurA N-terminal domain; Region: SurA_N; pfam09312
224324003792	SurA N-terminal domain; Region: SurA_N_3; cl07813
224324003793	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
224324003794	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
224324003795	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
224324003796	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; pfam02366
224324003797	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
224324003798	active site
224324003799	tetramer interface; other site
224324003800	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
224324003801	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
224324003802	active site
224324003803	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
224324003804	Lumazine binding domain; Region: Lum_binding; pfam00677
224324003805	Lumazine binding domain; Region: Lum_binding; pfam00677
224324003806	6-phosphofructokinase; Provisional; Region: PRK03202
224324003807	active site
224324003808	ADP/pyrophosphate binding site [chemical binding]; other site
224324003809	dimerization interface [polypeptide binding]; other site
224324003810	allosteric effector site; other site
224324003811	fructose-1,6-bisphosphate binding site; other site
224324003812	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
224324003813	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
224324003814	THF binding site; other site
224324003815	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
224324003816	substrate binding site [chemical binding]; other site
224324003817	THF binding site; other site
224324003818	zinc-binding site [ion binding]; other site
224324003819	ornithine carbamoyltransferase; Region: orni_carb_tr; TIGR00658
224324003820	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
224324003821	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
224324003822	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
224324003823	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
224324003824	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
224324003825	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
224324003826	NAD(P) binding site [chemical binding]; other site
224324003827	homotetramer interface [polypeptide binding]; other site
224324003828	homodimer interface [polypeptide binding]; other site
224324003829	active site
224324003830	acyl carrier protein; Provisional; Region: acpP; PRK00982
224324003831	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
224324003832	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
224324003833	dimer interface [polypeptide binding]; other site
224324003834	active site
224324003835	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
224324003836	active site
224324003837	dimer interface [polypeptide binding]; other site
224324003838	Hemerythrin; Region: Hemerythrin; cd12107
224324003839	Fe binding site [ion binding]; other site
224324003840	signal recognition particle protein; Provisional; Region: PRK10867
224324003841	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
224324003842	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
224324003843	P loop; other site
224324003844	GTP binding site [chemical binding]; other site
224324003845	Signal peptide binding domain; Region: SRP_SPB; pfam02978
224324003846	Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577
224324003847	active site
224324003848	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
224324003849	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
224324003850	inhibitor-cofactor binding pocket; inhibition site
224324003851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324003852	catalytic residue [active]
224324003853	GTP-binding protein LepA; Provisional; Region: PRK05433
224324003854	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
224324003855	G1 box; other site
224324003856	putative GEF interaction site [polypeptide binding]; other site
224324003857	GTP/Mg2+ binding site [chemical binding]; other site
224324003858	Switch I region; other site
224324003859	G2 box; other site
224324003860	G3 box; other site
224324003861	Switch II region; other site
224324003862	G4 box; other site
224324003863	G5 box; other site
224324003864	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
224324003865	Elongation Factor G, domain II; Region: EFG_II; pfam14492
224324003866	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
224324003867	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
224324003868	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
224324003869	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
224324003870	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
224324003871	DsrE/DsrF-like family; Region: DrsE; pfam02635
224324003872	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
224324003873	CPxP  motif; other site
224324003874	phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472
224324003875	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
224324003876	putative tRNA-binding site [nucleotide binding]; other site
224324003877	B3/4 domain; Region: B3_4; pfam03483
224324003878	tRNA synthetase B5 domain; Region: B5; pfam03484
224324003879	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
224324003880	dimer interface [polypeptide binding]; other site
224324003881	motif 1; other site
224324003882	motif 3; other site
224324003883	motif 2; other site
224324003884	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
224324003885	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
224324003886	phosphodiesterase; Provisional; Region: PRK12704
224324003887	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
224324003888	KH domain; Region: KH_1; pfam00013
224324003889	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224324003890	Zn2+ binding site [ion binding]; other site
224324003891	Mg2+ binding site [ion binding]; other site
224324003892	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
224324003893	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
224324003894	HSP70 interaction site [polypeptide binding]; other site
224324003895	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
224324003896	substrate binding site [polypeptide binding]; other site
224324003897	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
224324003898	Zn binding sites [ion binding]; other site
224324003899	dimer interface [polypeptide binding]; other site
224324003900	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
224324003901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324003902	S-adenosylmethionine binding site [chemical binding]; other site
224324003903	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
224324003904	Fe-S cluster binding site [ion binding]; other site
224324003905	substrate binding site [chemical binding]; other site
224324003906	catalytic site [active]
224324003907	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
224324003908	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224324003909	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
224324003910	EamA-like transporter family; Region: EamA; cl17759
224324003911	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
224324003912	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
224324003913	putative metal binding site; other site
224324003914	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224324003915	Peptidase family M23; Region: Peptidase_M23; pfam01551
224324003916	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224324003917	catalytic core [active]
224324003918	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
224324003919	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
224324003920	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224324003921	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224324003922	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
224324003923	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
224324003924	active site
224324003925	HIGH motif; other site
224324003926	dimer interface [polypeptide binding]; other site
224324003927	KMSKS motif; other site
224324003928	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324003929	RNA binding surface [nucleotide binding]; other site
224324003930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2952
224324003931	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224324003932	Peptidase family M23; Region: Peptidase_M23; pfam01551
224324003933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324003934	prephenate dehydrogenase; Validated; Region: PRK08507
224324003935	Prephenate dehydrogenase; Region: PDH; pfam02153
224324003936	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
224324003937	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
224324003938	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
224324003939	RNA binding surface [nucleotide binding]; other site
224324003940	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
224324003941	active site
224324003942	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
224324003943	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
224324003944	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
224324003945	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
224324003946	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
224324003947	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
224324003948	TPP-binding site [chemical binding]; other site
224324003949	dimer interface [polypeptide binding]; other site
224324003950	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
224324003951	PYR/PP interface [polypeptide binding]; other site
224324003952	dimer interface [polypeptide binding]; other site
224324003953	TPP binding site [chemical binding]; other site
224324003954	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
224324003955	Ribosomal protein S20; Region: Ribosomal_S20p; pfam01649
224324003956	ribonuclease HIII; Region: rnhC; TIGR00716
224324003957	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
224324003958	Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782
224324003959	RNA/DNA hybrid binding site [nucleotide binding]; other site
224324003960	active site
224324003961	FAD binding domain; Region: FAD_binding_4; pfam01565
224324003962	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
224324003963	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
224324003964	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
224324003965	active site
224324003966	KMSKS motif; other site
224324003967	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
224324003968	tRNA binding surface [nucleotide binding]; other site
224324003969	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
224324003970	active site
224324003971	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774
224324003972	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
224324003973	Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066
224324003974	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
224324003975	Walker A motif; other site
224324003976	ATP binding site [chemical binding]; other site
224324003977	Walker B motif; other site
224324003978	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
224324003979	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
224324003980	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
224324003981	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
224324003982	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
224324003983	fumarate hydratase; Provisional; Region: PRK06246
224324003984	malate dehydrogenase; Reviewed; Region: PRK06223
224324003985	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
224324003986	NAD(P) binding site [chemical binding]; other site
224324003987	dimer interface [polypeptide binding]; other site
224324003988	tetramer (dimer of dimers) interface [polypeptide binding]; other site
224324003989	substrate binding site [chemical binding]; other site
224324003990	aconitate hydratase, putative, Aquifex type; Region: acon_putative; TIGR01342
224324003991	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
224324003992	substrate binding site [chemical binding]; other site
224324003993	ligand binding site [chemical binding]; other site
224324003994	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
224324003995	substrate binding site [chemical binding]; other site
224324003996	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
224324003997	active site
224324003998	ribulose/triose binding site [chemical binding]; other site
224324003999	phosphate binding site [ion binding]; other site
224324004000	substrate (anthranilate) binding pocket [chemical binding]; other site
224324004001	product (indole) binding pocket [chemical binding]; other site
224324004002	integral membrane protein MviN; Region: mviN; TIGR01695
224324004003	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
224324004004	Archaeal fructose 1,6-bisphosphatase [Carbohydrate transport and metabolism]; Region: COG1980
224324004005	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
224324004006	GAF domain; Region: GAF; pfam01590
224324004007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324004008	Walker A motif; other site
224324004009	ATP binding site [chemical binding]; other site
224324004010	Walker B motif; other site
224324004011	arginine finger; other site
224324004012	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
224324004013	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
224324004014	putative active site [active]
224324004015	metal binding site [ion binding]; metal-binding site
224324004016	homodimer binding site [polypeptide binding]; other site
224324004017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004018	binding surface
224324004019	TPR motif; other site
224324004020	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
224324004021	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
224324004022	N-acetyl-D-glucosamine binding site [chemical binding]; other site
224324004023	catalytic residue [active]
224324004024	Uncharacterized conserved protein [Function unknown]; Region: COG4911
224324004025	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
224324004026	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
224324004027	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
224324004028	active site residue [active]
224324004029	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
224324004030	active site residue [active]
224324004031	Uncharacterized conserved protein [Function unknown]; Region: COG3439
224324004032	Uncharacterized conserved protein [Function unknown]; Region: COG3439
224324004033	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
224324004034	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
224324004035	active site
224324004036	metal binding site [ion binding]; metal-binding site
224324004037	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
224324004038	Cytochrome c; Region: Cytochrom_C; pfam00034
224324004039	Cytochrome c [Energy production and conversion]; Region: COG3258
224324004040	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
224324004041	Predicted secreted protein [Function unknown]; Region: COG5501
224324004042	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
224324004043	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
224324004044	homoserine dehydrogenase; Provisional; Region: PRK06349
224324004045	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
224324004046	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
224324004047	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
224324004048	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
224324004049	Predicted GTPase [General function prediction only]; Region: COG0218
224324004050	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
224324004051	G1 box; other site
224324004052	GTP/Mg2+ binding site [chemical binding]; other site
224324004053	Switch I region; other site
224324004054	G2 box; other site
224324004055	G3 box; other site
224324004056	Switch II region; other site
224324004057	G4 box; other site
224324004058	G5 box; other site
224324004059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324004060	S-adenosylmethionine binding site [chemical binding]; other site
224324004061	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
224324004062	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
224324004063	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
224324004064	putative active site [active]
224324004065	putative substrate binding site [chemical binding]; other site
224324004066	putative cosubstrate binding site; other site
224324004067	catalytic site [active]
224324004068	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
224324004069	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
224324004070	dimer interface [polypeptide binding]; other site
224324004071	active site residues [active]
224324004072	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
224324004073	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
224324004074	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
224324004075	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
224324004076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
224324004077	dimerization interface [polypeptide binding]; other site
224324004078	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
224324004079	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
224324004080	active site
224324004081	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
224324004082	dimer interface [polypeptide binding]; other site
224324004083	substrate binding site [chemical binding]; other site
224324004084	catalytic residues [active]
224324004085	Predicted membrane protein [Function unknown]; Region: COG3174
224324004086	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
224324004087	Predicted membrane protein [Function unknown]; Region: COG3174
224324004088	MgtC family; Region: MgtC; pfam02308
224324004089	30S ribosomal protein S7; Validated; Region: PRK05302
224324004090	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
224324004091	S17 interaction site [polypeptide binding]; other site
224324004092	S8 interaction site; other site
224324004093	16S rRNA interaction site [nucleotide binding]; other site
224324004094	streptomycin interaction site [chemical binding]; other site
224324004095	23S rRNA interaction site [nucleotide binding]; other site
224324004096	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
224324004097	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
224324004098	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
224324004099	dimerization interface [polypeptide binding]; other site
224324004100	ATP binding site [chemical binding]; other site
224324004101	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
224324004102	dimerization interface [polypeptide binding]; other site
224324004103	ATP binding site [chemical binding]; other site
224324004104	lipoprotein signal peptidase; Provisional; Region: PRK14779
224324004105	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
224324004106	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224324004107	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
224324004108	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
224324004109	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
224324004110	metal-binding site [ion binding]
224324004111	peptide chain release factor 2; Region: prfB; TIGR00020
224324004112	This domain is found in peptide chain release factors; Region: PCRF; smart00937
224324004113	RF-1 domain; Region: RF-1; pfam00472
224324004114	Cell division protein FtsA; Region: FtsA; cl17206
224324004115	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
224324004116	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
224324004117	G1 box; other site
224324004118	GTP/Mg2+ binding site [chemical binding]; other site
224324004119	G2 box; other site
224324004120	Switch I region; other site
224324004121	G3 box; other site
224324004122	Switch II region; other site
224324004123	G4 box; other site
224324004124	G5 box; other site
224324004125	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
224324004126	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
224324004127	Spc7 kinetochore protein; Region: Spc7; pfam08317
224324004128	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
224324004129	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
224324004130	putative valine binding site [chemical binding]; other site
224324004131	dimer interface [polypeptide binding]; other site
224324004132	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
224324004133	PLD-like domain; Region: PLDc_2; pfam13091
224324004134	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
224324004135	putative active site [active]
224324004136	catalytic site [active]
224324004137	HerA helicase [Replication, recombination, and repair]; Region: COG0433
224324004138	Domain of unknown function DUF87; Region: DUF87; pfam01935
224324004139	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
224324004140	Peptidase family M50; Region: Peptidase_M50; pfam02163
224324004141	active site
224324004142	putative substrate binding region [chemical binding]; other site
224324004143	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
224324004144	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14953
224324004145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324004146	Walker A motif; other site
224324004147	ATP binding site [chemical binding]; other site
224324004148	DNA polymerase III subunit delta'; Validated; Region: PRK08485
224324004149	Walker B motif; other site
224324004150	arginine finger; other site
224324004151	excinuclease ABC subunit B; Provisional; Region: PRK05298
224324004152	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324004153	ATP binding site [chemical binding]; other site
224324004154	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
224324004155	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324004156	putative Mg++ binding site [ion binding]; other site
224324004157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224324004158	nucleotide binding region [chemical binding]; other site
224324004159	ATP-binding site [chemical binding]; other site
224324004160	Ultra-violet resistance protein B; Region: UvrB; pfam12344
224324004161	UvrB/uvrC motif; Region: UVR; pfam02151
224324004162	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
224324004163	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
224324004164	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
224324004165	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
224324004166	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
224324004167	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224324004168	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
224324004169	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
224324004170	Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580
224324004171	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
224324004172	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004173	FeS/SAM binding site; other site
224324004174	Ion transport protein; Region: Ion_trans; pfam00520
224324004175	Ion channel; Region: Ion_trans_2; pfam07885
224324004176	TrkA-N domain; Region: TrkA_N; pfam02254
224324004177	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
224324004178	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
224324004179	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
224324004180	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
224324004181	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
224324004182	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
224324004183	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
224324004184	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
224324004185	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
224324004186	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
224324004187	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
224324004188	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
224324004189	23S rRNA interface [nucleotide binding]; other site
224324004190	L3 interface [polypeptide binding]; other site
224324004191	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
224324004192	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
224324004193	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
224324004194	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
224324004195	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
224324004196	DNA polymerase III beta subunit; Region: POL3Bc; smart00480
224324004197	putative DNA binding surface [nucleotide binding]; other site
224324004198	dimer interface [polypeptide binding]; other site
224324004199	beta-clamp/clamp loader binding surface; other site
224324004200	beta-clamp/translesion DNA polymerase binding surface; other site
224324004201	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
224324004202	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
224324004203	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
224324004204	active site
224324004205	metal binding site [ion binding]; metal-binding site
224324004206	DNA binding site [nucleotide binding]
224324004207	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
224324004208	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
224324004209	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
224324004210	Ligand Binding Site [chemical binding]; other site
224324004211	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
224324004212	CoA binding domain; Region: CoA_binding; pfam02629
224324004213	CoA-ligase; Region: Ligase_CoA; pfam00549
224324004214	Quinolinate synthetase A protein; Region: NadA; pfam02445
224324004215	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
224324004216	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
224324004217	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
224324004218	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
224324004219	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
224324004220	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
224324004221	metal binding site [ion binding]; metal-binding site
224324004222	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
224324004223	homodimer interface [polypeptide binding]; other site
224324004224	substrate-cofactor binding pocket; other site
224324004225	catalytic residue [active]
224324004226	cell division protein FtsN; Region: ftsN; TIGR02223
224324004227	Sporulation related domain; Region: SPOR; pfam05036
224324004228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004229	binding surface
224324004230	TPR motif; other site
224324004231	TPR repeat; Region: TPR_11; pfam13414
224324004232	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224324004233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004234	binding surface
224324004235	TPR motif; other site
224324004236	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
224324004237	Sporulation related domain; Region: SPOR; pfam05036
224324004238	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
224324004239	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
224324004240	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
224324004241	homodimer interface [polypeptide binding]; other site
224324004242	NADP binding site [chemical binding]; other site
224324004243	substrate binding site [chemical binding]; other site
224324004244	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
224324004245	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
224324004246	Ligand binding site; other site
224324004247	Putative Catalytic site; other site
224324004248	DXD motif; other site
224324004249	Haemagglutinin; Region: Hemagglutinin; pfam00509
224324004250	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
224324004251	putative active site [active]
224324004252	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
224324004253	tetramer interface [polypeptide binding]; other site
224324004254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324004255	catalytic residue [active]
224324004256	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
224324004257	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
224324004258	ligand binding site [chemical binding]; other site
224324004259	NAD binding site [chemical binding]; other site
224324004260	dimerization interface [polypeptide binding]; other site
224324004261	catalytic site [active]
224324004262	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
224324004263	putative L-serine binding site [chemical binding]; other site
224324004264	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324004265	active site
224324004266	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
224324004267	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
224324004268	HflX GTPase family; Region: HflX; cd01878
224324004269	G1 box; other site
224324004270	GTP/Mg2+ binding site [chemical binding]; other site
224324004271	Switch I region; other site
224324004272	G2 box; other site
224324004273	G3 box; other site
224324004274	Switch II region; other site
224324004275	G4 box; other site
224324004276	G5 box; other site
224324004277	bacterial Hfq-like; Region: Hfq; cd01716
224324004278	hexamer interface [polypeptide binding]; other site
224324004279	Sm1 motif; other site
224324004280	RNA binding site [nucleotide binding]; other site
224324004281	Sm2 motif; other site
224324004282	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
224324004283	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224324004284	Zn2+ binding site [ion binding]; other site
224324004285	Mg2+ binding site [ion binding]; other site
224324004286	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
224324004287	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
224324004288	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
224324004289	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
224324004290	catalytic residues [active]
224324004291	PilZ domain; Region: PilZ; pfam07238
224324004292	GTP-binding protein Der; Reviewed; Region: PRK00093
224324004293	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
224324004294	G1 box; other site
224324004295	GTP/Mg2+ binding site [chemical binding]; other site
224324004296	Switch I region; other site
224324004297	G2 box; other site
224324004298	Switch II region; other site
224324004299	G3 box; other site
224324004300	G4 box; other site
224324004301	G5 box; other site
224324004302	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
224324004303	G1 box; other site
224324004304	GTP/Mg2+ binding site [chemical binding]; other site
224324004305	Switch I region; other site
224324004306	G2 box; other site
224324004307	G3 box; other site
224324004308	Switch II region; other site
224324004309	G4 box; other site
224324004310	G5 box; other site
224324004311	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
224324004312	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
224324004313	3-dehydroquinate synthase; Provisional; Region: PRK02290
224324004314	pantothenate kinase, type III; Region: baf; TIGR00671
224324004315	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
224324004316	elongation factor Tu; Reviewed; Region: PRK00049
224324004317	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
224324004318	G1 box; other site
224324004319	GEF interaction site [polypeptide binding]; other site
224324004320	GTP/Mg2+ binding site [chemical binding]; other site
224324004321	Switch I region; other site
224324004322	G2 box; other site
224324004323	G3 box; other site
224324004324	Switch II region; other site
224324004325	G4 box; other site
224324004326	G5 box; other site
224324004327	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
224324004328	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
224324004329	Antibiotic Binding Site [chemical binding]; other site
224324004330	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
224324004331	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
224324004332	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
224324004333	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
224324004334	putative homodimer interface [polypeptide binding]; other site
224324004335	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
224324004336	heterodimer interface [polypeptide binding]; other site
224324004337	homodimer interface [polypeptide binding]; other site
224324004338	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
224324004339	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
224324004340	23S rRNA interface [nucleotide binding]; other site
224324004341	L7/L12 interface [polypeptide binding]; other site
224324004342	putative thiostrepton binding site; other site
224324004343	L25 interface [polypeptide binding]; other site
224324004344	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
224324004345	mRNA/rRNA interface [nucleotide binding]; other site
224324004346	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
224324004347	23S rRNA interface [nucleotide binding]; other site
224324004348	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
224324004349	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
224324004350	core dimer interface [polypeptide binding]; other site
224324004351	peripheral dimer interface [polypeptide binding]; other site
224324004352	L10 interface [polypeptide binding]; other site
224324004353	L11 interface [polypeptide binding]; other site
224324004354	putative EF-Tu interaction site [polypeptide binding]; other site
224324004355	putative EF-G interaction site [polypeptide binding]; other site
224324004356	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
224324004357	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
224324004358	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
224324004359	RPB1 interaction site [polypeptide binding]; other site
224324004360	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
224324004361	RPB10 interaction site [polypeptide binding]; other site
224324004362	RPB11 interaction site [polypeptide binding]; other site
224324004363	RPB3 interaction site [polypeptide binding]; other site
224324004364	RPB12 interaction site [polypeptide binding]; other site
224324004365	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
224324004366	beta and beta' interface [polypeptide binding]; other site
224324004367	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
224324004368	beta' and sigma factor interface [polypeptide binding]; other site
224324004369	Zn-binding [ion binding]; other site
224324004370	active site region [active]
224324004371	catalytic site [active]
224324004372	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
224324004373	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
224324004374	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
224324004375	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
224324004376	DNA binding site [nucleotide binding]
224324004377	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
224324004378	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
224324004379	Subtilase family; Region: Peptidase_S8; pfam00082
224324004380	catalytic triad [active]
224324004381	putative active site [active]
224324004382	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
224324004383	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
224324004384	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
224324004385	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
224324004386	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
224324004387	RNA/DNA hybrid binding site [nucleotide binding]; other site
224324004388	active site
224324004389	Thermus thermophilus Tt1561 and related proteins, metallophosphatase domain; Region: MPP_Tt1561; cd07388
224324004390	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
224324004391	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004392	FeS/SAM binding site; other site
224324004393	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
224324004394	dimer interface [polypeptide binding]; other site
224324004395	substrate binding site [chemical binding]; other site
224324004396	ATP binding site [chemical binding]; other site
224324004397	flagellar biosynthetic protein FliR; Region: fliR; TIGR01400
224324004398	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
224324004399	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
224324004400	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
224324004401	purine monophosphate binding site [chemical binding]; other site
224324004402	dimer interface [polypeptide binding]; other site
224324004403	putative catalytic residues [active]
224324004404	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; pfam01808
224324004405	RIP metalloprotease RseP; Region: TIGR00054
224324004406	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
224324004407	active site
224324004408	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
224324004409	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
224324004410	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
224324004411	putative substrate binding region [chemical binding]; other site
224324004412	Uncharacterized conserved protein [Function unknown]; Region: COG0432
224324004413	Protein of unknown function (DUF1122); Region: DUF1122; pfam06557
224324004414	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
224324004415	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
224324004416	catalytic site [active]
224324004417	putative active site [active]
224324004418	putative substrate binding site [chemical binding]; other site
224324004419	Phylum Aquificae Pol A is different from Escherichia coli  Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639
224324004420	active site
224324004421	DNA binding site [nucleotide binding]
224324004422	catalytic site [active]
224324004423	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
224324004424	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
224324004425	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
224324004426	metal binding site [ion binding]; metal-binding site
224324004427	aspartate aminotransferase; Provisional; Region: PRK05764
224324004428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224324004429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324004430	homodimer interface [polypeptide binding]; other site
224324004431	catalytic residue [active]
224324004432	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
224324004433	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
224324004434	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
224324004435	Walker A motif; other site
224324004436	ATP binding site [chemical binding]; other site
224324004437	Walker B motif; other site
224324004438	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
224324004439	oligomerization interface [polypeptide binding]; other site
224324004440	active site
224324004441	metal binding site [ion binding]; metal-binding site
224324004442	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
224324004443	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
224324004444	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
224324004445	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324004446	motif II; other site
224324004447	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
224324004448	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
224324004449	intersubunit interface [polypeptide binding]; other site
224324004450	active site
224324004451	Zn2+ binding site [ion binding]; other site
224324004452	Uncharacterized conserved protein [Function unknown]; Region: COG4121
224324004453	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
224324004454	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
224324004455	active site
224324004456	dimerization interface [polypeptide binding]; other site
224324004457	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
224324004458	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
224324004459	CoA-binding site [chemical binding]; other site
224324004460	ATP-binding [chemical binding]; other site
224324004461	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
224324004462	putative active site [active]
224324004463	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
224324004464	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
224324004465	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
224324004466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004467	binding surface
224324004468	TPR motif; other site
224324004469	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
224324004470	catalytic core [active]
224324004471	Peptidase family M48; Region: Peptidase_M48; cl12018
224324004472	Uncharacterized conserved protein [Function unknown]; Region: COG3868
224324004473	GTPase Era; Reviewed; Region: era; PRK00089
224324004474	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
224324004475	G1 box; other site
224324004476	GTP/Mg2+ binding site [chemical binding]; other site
224324004477	Switch I region; other site
224324004478	G2 box; other site
224324004479	Switch II region; other site
224324004480	G3 box; other site
224324004481	G4 box; other site
224324004482	G5 box; other site
224324004483	KH domain; Region: KH_2; pfam07650
224324004484	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
224324004485	Dienelactone hydrolase family; Region: DLH; pfam01738
224324004486	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
224324004487	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
224324004488	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
224324004489	Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334
224324004490	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
224324004491	Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465
224324004492	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
224324004493	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
224324004494	Flagellar protein FliS; Region: FliS; pfam02561
224324004495	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
224324004496	rRNA interaction site [nucleotide binding]; other site
224324004497	S8 interaction site; other site
224324004498	putative laminin-1 binding site; other site
224324004499	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
224324004500	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
224324004501	dimerization interface [polypeptide binding]; other site
224324004502	domain crossover interface; other site
224324004503	redox-dependent activation switch; other site
224324004504	Tim44-like domain; Region: Tim44; cl09208
224324004505	MoxR-like ATPases [General function prediction only]; Region: COG0714
224324004506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
224324004507	Walker A motif; other site
224324004508	ATP binding site [chemical binding]; other site
224324004509	Walker B motif; other site
224324004510	arginine finger; other site
224324004511	Uncharacterized conserved protein [Function unknown]; Region: COG0432
224324004512	flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328
224324004513	protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562
224324004514	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
224324004515	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224324004516	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
224324004517	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
224324004518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224324004519	dimer interface [polypeptide binding]; other site
224324004520	conserved gate region; other site
224324004521	putative PBP binding loops; other site
224324004522	ABC-ATPase subunit interface; other site
224324004523	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
224324004524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
224324004525	dimer interface [polypeptide binding]; other site
224324004526	conserved gate region; other site
224324004527	putative PBP binding loops; other site
224324004528	ABC-ATPase subunit interface; other site
224324004529	DsrE/DsrF-like family; Region: DrsE; pfam02635
224324004530	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
224324004531	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
224324004532	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
224324004533	active site
224324004534	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
224324004535	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
224324004536	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
224324004537	Zn2+ binding site [ion binding]; other site
224324004538	Mg2+ binding site [ion binding]; other site
224324004539	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
224324004540	metal binding site [ion binding]; metal-binding site
224324004541	nucleotidyl binding site; other site
224324004542	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
224324004543	TrkA-C domain; Region: TrkA_C; pfam02080
224324004544	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
224324004545	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224324004546	translation initiation factor IF-2; Validated; Region: infB; PRK05306
224324004547	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
224324004548	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
224324004549	G1 box; other site
224324004550	putative GEF interaction site [polypeptide binding]; other site
224324004551	GTP/Mg2+ binding site [chemical binding]; other site
224324004552	Switch I region; other site
224324004553	G2 box; other site
224324004554	G3 box; other site
224324004555	Switch II region; other site
224324004556	G4 box; other site
224324004557	G5 box; other site
224324004558	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
224324004559	Translation-initiation factor 2; Region: IF-2; pfam11987
224324004560	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
224324004561	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
224324004562	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
224324004563	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004564	FeS/SAM binding site; other site
224324004565	integral membrane protein TIGR01906; Region: integ_TIGR01906
224324004566	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
224324004567	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
224324004568	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
224324004569	alpha subunit interaction interface [polypeptide binding]; other site
224324004570	Walker A motif; other site
224324004571	ATP binding site [chemical binding]; other site
224324004572	Walker B motif; other site
224324004573	inhibitor binding site; inhibition site
224324004574	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
224324004575	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
224324004576	core domain interface [polypeptide binding]; other site
224324004577	delta subunit interface [polypeptide binding]; other site
224324004578	epsilon subunit interface [polypeptide binding]; other site
224324004579	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
224324004580	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
224324004581	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
224324004582	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
224324004583	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
224324004584	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
224324004585	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
224324004586	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
224324004587	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224324004588	ribonuclease R; Region: RNase_R; TIGR02063
224324004589	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
224324004590	RNB domain; Region: RNB; pfam00773
224324004591	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
224324004592	RNA binding site [nucleotide binding]; other site
224324004593	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
224324004594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
224324004595	putative DNA binding site [nucleotide binding]; other site
224324004596	putative Zn2+ binding site [ion binding]; other site
224324004597	NosL; Region: NosL; cl01769
224324004598	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
224324004599	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
224324004600	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
224324004601	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
224324004602	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
224324004603	ssDNA binding site; other site
224324004604	generic binding surface II; other site
224324004605	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324004606	ATP binding site [chemical binding]; other site
224324004607	putative Mg++ binding site [ion binding]; other site
224324004608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
224324004609	nucleotide binding region [chemical binding]; other site
224324004610	ATP-binding site [chemical binding]; other site
224324004611	Family of unknown function (DUF490); Region: DUF490; pfam04357
224324004612	Predicted transcriptional regulators [Transcription]; Region: COG1318
224324004613	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
224324004614	MTH865-like family; Region: MTH865; cl01962
224324004615	AAA domain; Region: AAA_11; pfam13086
224324004616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
224324004617	ATP binding site [chemical binding]; other site
224324004618	AAA domain; Region: AAA_12; pfam13087
224324004619	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
224324004620	putative acyl-acceptor binding pocket; other site
224324004621	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
224324004622	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324004623	active site
224324004624	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
224324004625	active site
224324004626	Radical SAM superfamily; Region: Radical_SAM; pfam04055
224324004627	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004628	FeS/SAM binding site; other site
224324004629	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
224324004630	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
224324004631	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
224324004632	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
224324004633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
224324004634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
224324004635	Predicted membrane protein [Function unknown]; Region: COG1238
224324004636	Domain of unknown function DUF77; Region: DUF77; pfam01910
224324004637	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
224324004638	nucleotide binding site [chemical binding]; other site
224324004639	homohexameric interface [polypeptide binding]; other site
224324004640	N-acetyl-L-glutamate binding site [chemical binding]; other site
224324004641	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
224324004642	GTP1/OBG; Region: GTP1_OBG; pfam01018
224324004643	Obg GTPase; Region: Obg; cd01898
224324004644	G1 box; other site
224324004645	GTP/Mg2+ binding site [chemical binding]; other site
224324004646	Switch I region; other site
224324004647	G2 box; other site
224324004648	G3 box; other site
224324004649	Switch II region; other site
224324004650	G4 box; other site
224324004651	G5 box; other site
224324004652	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
224324004653	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
224324004654	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
224324004655	putative RNA binding site [nucleotide binding]; other site
224324004656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324004657	S-adenosylmethionine binding site [chemical binding]; other site
224324004658	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
224324004659	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
224324004660	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
224324004661	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
224324004662	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
224324004663	active site
224324004664	Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333
224324004665	Na2 binding site [ion binding]; other site
224324004666	substrate binding site 1 [chemical binding]; other site
224324004667	Na binding site 1 [ion binding]; other site
224324004668	substrate binding site 2 [chemical binding]; other site
224324004669	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
224324004670	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
224324004671	tandem repeat interface [polypeptide binding]; other site
224324004672	oligomer interface [polypeptide binding]; other site
224324004673	active site residues [active]
224324004674	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
224324004675	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
224324004676	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224324004677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324004678	homodimer interface [polypeptide binding]; other site
224324004679	catalytic residue [active]
224324004680	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
224324004681	putative active site [active]
224324004682	putative metal binding site [ion binding]; other site
224324004683	Predicted membrane protein [Function unknown]; Region: COG3431
224324004684	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
224324004685	2-isopropylmalate synthase; Validated; Region: PRK00915
224324004686	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
224324004687	active site
224324004688	catalytic residues [active]
224324004689	metal binding site [ion binding]; metal-binding site
224324004690	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
224324004691	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
224324004692	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
224324004693	dimerization domain [polypeptide binding]; other site
224324004694	dimer interface [polypeptide binding]; other site
224324004695	catalytic residues [active]
224324004696	aminotransferase; Validated; Region: PRK08175
224324004697	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
224324004698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
224324004699	homodimer interface [polypeptide binding]; other site
224324004700	catalytic residue [active]
224324004701	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
224324004702	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
224324004703	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
224324004704	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
224324004705	FAD binding pocket [chemical binding]; other site
224324004706	FAD binding motif [chemical binding]; other site
224324004707	phosphate binding motif [ion binding]; other site
224324004708	beta-alpha-beta structure motif; other site
224324004709	NAD binding pocket [chemical binding]; other site
224324004710	Iron coordination center [ion binding]; other site
224324004711	multifunctional aminopeptidase A; Provisional; Region: PRK00913
224324004712	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
224324004713	interface (dimer of trimers) [polypeptide binding]; other site
224324004714	Substrate-binding/catalytic site; other site
224324004715	Zn-binding sites [ion binding]; other site
224324004716	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
224324004717	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
224324004718	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
224324004719	Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787
224324004720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
224324004721	Methyltransferase domain; Region: Methyltransf_31; pfam13847
224324004722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324004723	S-adenosylmethionine binding site [chemical binding]; other site
224324004724	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
224324004725	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
224324004726	ligand binding site [chemical binding]; other site
224324004727	flexible hinge region; other site
224324004728	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
224324004729	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
224324004730	metal binding triad; other site
224324004731	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
224324004732	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
224324004733	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
224324004734	active site
224324004735	catalytic site [active]
224324004736	substrate binding site [chemical binding]; other site
224324004737	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
224324004738	dimer interface [polypeptide binding]; other site
224324004739	active site
224324004740	Schiff base residues; other site
224324004741	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
224324004742	active site
224324004743	Zn binding site [ion binding]; other site
224324004744	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
224324004745	Peptidase family M23; Region: Peptidase_M23; pfam01551
224324004746	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
224324004747	active site 2 [active]
224324004748	active site 1 [active]
224324004749	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
224324004750	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
224324004751	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
224324004752	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
224324004753	ATP binding site [chemical binding]; other site
224324004754	active site
224324004755	substrate binding site [chemical binding]; other site
224324004756	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
224324004757	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
224324004758	thiamine-monophosphate kinase; Region: thiL; TIGR01379
224324004759	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
224324004760	ATP binding site [chemical binding]; other site
224324004761	dimerization interface [polypeptide binding]; other site
224324004762	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
224324004763	Domain of unknown function DUF21; Region: DUF21; pfam01595
224324004764	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
224324004765	Transporter associated domain; Region: CorC_HlyC; smart01091
224324004766	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
224324004767	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224324004768	Walker A/P-loop; other site
224324004769	ATP binding site [chemical binding]; other site
224324004770	Q-loop/lid; other site
224324004771	ABC transporter signature motif; other site
224324004772	Walker B; other site
224324004773	D-loop; other site
224324004774	H-loop/switch region; other site
224324004775	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
224324004776	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
224324004777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004778	FeS/SAM binding site; other site
224324004779	HemN C-terminal domain; Region: HemN_C; pfam06969
224324004780	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14667
224324004781	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
224324004782	GIY-YIG motif/motif A; other site
224324004783	active site
224324004784	catalytic site [active]
224324004785	putative DNA binding site [nucleotide binding]; other site
224324004786	metal binding site [ion binding]; metal-binding site
224324004787	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
224324004788	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
224324004789	bile acid transporter; Region: bass; TIGR00841
224324004790	methionyl-tRNA formyltransferase; Region: fmt; TIGR00460
224324004791	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
224324004792	putative active site [active]
224324004793	substrate binding site [chemical binding]; other site
224324004794	putative cosubstrate binding site; other site
224324004795	catalytic site [active]
224324004796	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
224324004797	substrate binding site [chemical binding]; other site
224324004798	Pantoate-beta-alanine ligase; Region: PanC; cd00560
224324004799	active site
224324004800	ATP-binding site [chemical binding]; other site
224324004801	pantoate-binding site; other site
224324004802	HXXH motif; other site
224324004803	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
224324004804	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
224324004805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
224324004806	Walker A/P-loop; other site
224324004807	ATP binding site [chemical binding]; other site
224324004808	Q-loop/lid; other site
224324004809	ABC transporter signature motif; other site
224324004810	Walker B; other site
224324004811	D-loop; other site
224324004812	H-loop/switch region; other site
224324004813	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
224324004814	Putative lysophospholipase; Region: Hydrolase_4; cl19140
224324004815	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
224324004816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
224324004817	S-adenosylmethionine binding site [chemical binding]; other site
224324004818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
224324004819	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
224324004820	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
224324004821	DALR anticodon binding domain; Region: DALR_1; pfam05746
224324004822	phosphoenolpyruvate synthase; Validated; Region: PRK06464
224324004823	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
224324004824	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700
224324004825	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
224324004826	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
224324004827	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
224324004828	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
224324004829	catalytic residues [active]
224324004830	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
224324004831	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
224324004832	fibritin; Provisional; Region: wac; PHA02607
224324004833	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
224324004834	ligand binding site [chemical binding]; other site
224324004835	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
224324004836	recombinase A; Provisional; Region: recA; PRK09354
224324004837	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
224324004838	hexamer interface [polypeptide binding]; other site
224324004839	Walker A motif; other site
224324004840	ATP binding site [chemical binding]; other site
224324004841	Walker B motif; other site
224324004842	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
224324004843	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
224324004844	Walker A motif; other site
224324004845	ATP binding site [chemical binding]; other site
224324004846	Walker B motif; other site
224324004847	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
224324004848	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
224324004849	CMP-binding site; other site
224324004850	The sites determining sugar specificity; other site
224324004851	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
224324004852	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
224324004853	DHH family; Region: DHH; pfam01368
224324004854	DHHA1 domain; Region: DHHA1; pfam02272
224324004855	Uncharacterized metal-binding protein [General function prediction only]; Region: COG2389
224324004856	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
224324004857	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
224324004858	active site
224324004859	NTP binding site [chemical binding]; other site
224324004860	metal binding triad [ion binding]; metal-binding site
224324004861	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
224324004862	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
224324004863	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
224324004864	nucleotide binding site/active site [active]
224324004865	HIT family signature motif; other site
224324004866	catalytic residue [active]
224324004867	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
224324004868	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
224324004869	Walker A/P-loop; other site
224324004870	ATP binding site [chemical binding]; other site
224324004871	Q-loop/lid; other site
224324004872	ABC transporter signature motif; other site
224324004873	Walker B; other site
224324004874	D-loop; other site
224324004875	H-loop/switch region; other site
224324004876	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
224324004877	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
224324004878	active site
224324004879	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
224324004880	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
224324004881	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
224324004882	putative ligand binding site [chemical binding]; other site
224324004883	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
224324004884	NAD+ binding site [chemical binding]; other site
224324004885	substrate binding site [chemical binding]; other site
224324004886	Zn binding site [ion binding]; other site
224324004887	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
224324004888	active site
224324004889	motif I; other site
224324004890	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
224324004891	motif II; other site
224324004892	Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200
224324004893	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
224324004894	OstA-like protein; Region: OstA; pfam03968
224324004895	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
224324004896	dimer interface [polypeptide binding]; other site
224324004897	DNA binding site [nucleotide binding]
224324004898	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
224324004899	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
224324004900	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
224324004901	ADP binding site [chemical binding]; other site
224324004902	magnesium binding site [ion binding]; other site
224324004903	putative shikimate binding site; other site
224324004904	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
224324004905	ThiS interaction site; other site
224324004906	putative active site [active]
224324004907	tetramer interface [polypeptide binding]; other site
224324004908	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
224324004909	thiS-thiF/thiG interaction site; other site
224324004910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224324004911	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224324004912	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
224324004913	MoaE homodimer interface [polypeptide binding]; other site
224324004914	MoaD interaction [polypeptide binding]; other site
224324004915	active site residues [active]
224324004916	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
224324004917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
224324004918	FeS/SAM binding site; other site
224324004919	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
224324004920	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
224324004921	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
224324004922	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
224324004923	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
224324004924	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
224324004925	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
224324004926	Subunit I/III interface [polypeptide binding]; other site
224324004927	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
224324004928	Cu(I) binding site [ion binding]; other site
224324004929	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
224324004930	Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_2; cd13915
224324004931	CuA binuclear center [ion binding]; other site
224324004932	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
224324004933	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
224324004934	Putative D-pathway homolog; other site
224324004935	Low-spin heme binding site [chemical binding]; other site
224324004936	Subunit I/II interface [polypeptide binding]; other site
224324004937	Putative Q-pathway; other site
224324004938	Putative alternate electron transfer pathway; other site
224324004939	Putative water exit pathway; other site
224324004940	Binuclear center (active site) [active]
224324004941	Putative K-pathway homolog; other site
224324004942	Putative proton exit pathway; other site
224324004943	Subunit I/IIa interface [polypeptide binding]; other site
224324004944	Electron transfer pathway; other site
224324004945	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
224324004946	Cu(I) binding site [ion binding]; other site
224324004947	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
224324004948	Uncharacterized conserved protein [Function unknown]; Region: COG1912
224324004949	TPR repeat; Region: TPR_11; pfam13414
224324004950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004951	binding surface
224324004952	TPR motif; other site
224324004953	Tetratricopeptide repeat; Region: TPR_12; pfam13424
224324004954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
224324004955	binding surface
224324004956	TPR motif; other site
224324004957	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
224324004958	oligomerisation interface [polypeptide binding]; other site
224324004959	mobile loop; other site
224324004960	roof hairpin; other site
224324004961	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
224324004962	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
224324004963	ring oligomerisation interface [polypeptide binding]; other site
224324004964	ATP/Mg binding site [chemical binding]; other site
224324004965	stacking interactions; other site
224324004966	hinge regions; other site
224324004967	DNA repair protein RecO; Region: reco; TIGR00613
224324004968	Recombination protein O C terminal; Region: RecO_C; pfam02565
224324004969	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
224324004970	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
224324004971	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
224324004972	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
224324004973	putative active site [active]
224324004974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
224324004975	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
224324004976	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
224324004977	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
224324004978	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
224324004979	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
224324004980	active site
224324004981	Int/Topo IB signature motif; other site
224324004982	catalytic residues [active]
224324004983	DNA binding site [nucleotide binding]
224324004984	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
224324004985	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
224324004986	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
224324004987	catalytic residues [active]
224324004988	DNA repair and recombination protein RadB; Region: recomb_radB; TIGR02237
224324004989	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
224324004990	Walker A motif; other site
224324004991	NTP binding site [chemical binding]; other site
224324004992	hexamer interface [polypeptide binding]; other site
224324004993	Walker B motif; other site
224324004994	Helix-turn-helix domain; Region: HTH_20; pfam12840
224324004995	putative Zn2+ binding site [ion binding]; other site
224324004996	putative DNA binding site [nucleotide binding]; other site
224324004997	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
224324004998	DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710
224324004999	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
224324005000	AAA domain; Region: AAA_14; pfam13173
224324005001	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
224324005002	putative active site [active]
224324005003	catalytic site [active]
224324005004	HerA helicase [Replication, recombination, and repair]; Region: COG0433
224324005005	HAS barrel domain; Region: HAS-barrel; pfam09378
224324005006	HerA helicase [Replication, recombination, and repair]; Region: COG0433
224324005007	Domain of unknown function DUF87; Region: DUF87; cl19135
224324005008	Protein of unknown function (DUF499); Region: DUF499; cl19819
224324005009	ParA-like protein; Provisional; Region: PHA02518
224324005010	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
224324005011	P-loop; other site
224324005012	Magnesium ion binding site [ion binding]; other site
224324005013	Fic family protein [Function unknown]; Region: COG3177
224324005014	Fic/DOC family; Region: Fic; pfam02661
224324005015	Helix-turn-helix domain; Region: HTH_17; cl17695
224324005016	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
224324005017	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609