-- dump date 20140618_204532 -- class Genbank::misc_feature -- table misc_feature_note -- id note 644284000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644284000003 Walker A motif; other site 644284000004 ATP binding site [chemical binding]; other site 644284000005 Walker B motif; other site 644284000006 arginine finger; other site 644284000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 644284000008 DnaA box-binding interface [nucleotide binding]; other site 644284000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 644284000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 644284000011 putative DNA binding surface [nucleotide binding]; other site 644284000012 dimer interface [polypeptide binding]; other site 644284000013 beta-clamp/clamp loader binding surface; other site 644284000014 beta-clamp/translesion DNA polymerase binding surface; other site 644284000015 recombination protein F; Reviewed; Region: recF; PRK00064 644284000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 644284000017 Walker A/P-loop; other site 644284000018 ATP binding site [chemical binding]; other site 644284000019 Q-loop/lid; other site 644284000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000021 ABC transporter signature motif; other site 644284000022 Walker B; other site 644284000023 D-loop; other site 644284000024 H-loop/switch region; other site 644284000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 644284000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 644284000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284000028 ATP binding site [chemical binding]; other site 644284000029 Mg2+ binding site [ion binding]; other site 644284000030 G-X-G motif; other site 644284000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644284000032 anchoring element; other site 644284000033 dimer interface [polypeptide binding]; other site 644284000034 ATP binding site [chemical binding]; other site 644284000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644284000036 active site 644284000037 putative metal-binding site [ion binding]; other site 644284000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644284000039 DNA gyrase subunit A; Validated; Region: PRK05560 644284000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644284000041 CAP-like domain; other site 644284000042 active site 644284000043 primary dimer interface [polypeptide binding]; other site 644284000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 644284000051 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 644284000052 Divergent AAA domain; Region: AAA_4; pfam04326 644284000053 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 644284000054 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 644284000055 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 644284000056 Sulfatase; Region: Sulfatase; cl17466 644284000057 Phosphotransferase enzyme family; Region: APH; pfam01636 644284000058 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644284000059 active site 644284000060 ATP binding site [chemical binding]; other site 644284000061 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 644284000062 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 644284000063 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 644284000064 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284000065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284000066 nucleotide binding site [chemical binding]; other site 644284000067 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 644284000068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284000069 Coenzyme A binding pocket [chemical binding]; other site 644284000070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284000071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284000072 Predicted membrane protein [Function unknown]; Region: COG1511 644284000073 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 644284000074 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 644284000075 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 644284000076 L-lactate permease; Region: Lactate_perm; cl00701 644284000077 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 644284000078 Cysteine-rich domain; Region: CCG; pfam02754 644284000079 Cysteine-rich domain; Region: CCG; pfam02754 644284000080 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 644284000081 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 644284000082 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 644284000083 Uncharacterized conserved protein [Function unknown]; Region: COG1556 644284000084 Cna protein B-type domain; Region: Cna_B; pfam05738 644284000085 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 644284000086 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644284000087 active site 644284000088 metal binding site [ion binding]; metal-binding site 644284000089 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644284000090 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 644284000091 catalytic site [active] 644284000092 BNR repeat-like domain; Region: BNR_2; pfam13088 644284000093 Asp-box motif; other site 644284000094 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 644284000095 BCCT family transporter; Region: BCCT; pfam02028 644284000096 Predicted permeases [General function prediction only]; Region: RarD; COG2962 644284000097 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 644284000098 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 644284000099 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 644284000100 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 644284000101 active site 644284000102 catalytic site [active] 644284000103 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 644284000104 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 644284000105 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 644284000106 active site 644284000107 catalytic site [active] 644284000108 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 644284000109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284000110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284000111 DNA binding site [nucleotide binding] 644284000112 domain linker motif; other site 644284000113 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644284000114 ligand binding site [chemical binding]; other site 644284000115 dimerization interface [polypeptide binding]; other site 644284000116 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644284000117 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 644284000118 putative substrate binding site [chemical binding]; other site 644284000119 putative ATP binding site [chemical binding]; other site 644284000120 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 644284000121 putative active cleft [active] 644284000122 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 644284000123 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263 644284000124 putative NAD(P) binding site [chemical binding]; other site 644284000125 catalytic Zn binding site [ion binding]; other site 644284000126 structural Zn binding site [ion binding]; other site 644284000127 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 644284000128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000129 putative substrate translocation pore; other site 644284000130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000131 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 644284000132 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 644284000133 DNA interaction; other site 644284000134 Metal-binding active site; metal-binding site 644284000135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644284000136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 644284000137 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 644284000138 Transaldolase; Region: Transaldolase; pfam00923 644284000139 catalytic residue [active] 644284000140 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644284000141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284000142 DNA-binding site [nucleotide binding]; DNA binding site 644284000143 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644284000144 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 644284000145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644284000146 substrate binding site [chemical binding]; other site 644284000147 ATP binding site [chemical binding]; other site 644284000148 KduI/IolB family; Region: KduI; pfam04962 644284000149 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 644284000150 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644284000151 PYR/PP interface [polypeptide binding]; other site 644284000152 dimer interface [polypeptide binding]; other site 644284000153 TPP binding site [chemical binding]; other site 644284000154 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 644284000155 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 644284000156 TPP-binding site; other site 644284000157 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 644284000158 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 644284000159 tetrameric interface [polypeptide binding]; other site 644284000160 NAD binding site [chemical binding]; other site 644284000161 catalytic residues [active] 644284000162 Uncharacterized conserved protein [Function unknown]; Region: COG5476 644284000163 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 644284000164 MlrC C-terminus; Region: MlrC_C; pfam07171 644284000165 Transcriptional regulators [Transcription]; Region: MarR; COG1846 644284000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284000167 dimerization interface [polypeptide binding]; other site 644284000168 putative Zn2+ binding site [ion binding]; other site 644284000169 putative DNA binding site [nucleotide binding]; other site 644284000170 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284000171 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284000172 nucleotide binding site [chemical binding]; other site 644284000173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644284000174 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644284000175 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 644284000176 peptide binding site [polypeptide binding]; other site 644284000177 dimer interface [polypeptide binding]; other site 644284000178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644284000179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000180 dimer interface [polypeptide binding]; other site 644284000181 conserved gate region; other site 644284000182 putative PBP binding loops; other site 644284000183 ABC-ATPase subunit interface; other site 644284000184 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644284000185 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644284000186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000187 dimer interface [polypeptide binding]; other site 644284000188 conserved gate region; other site 644284000189 putative PBP binding loops; other site 644284000190 ABC-ATPase subunit interface; other site 644284000191 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 644284000192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284000193 Walker A/P-loop; other site 644284000194 ATP binding site [chemical binding]; other site 644284000195 Q-loop/lid; other site 644284000196 ABC transporter signature motif; other site 644284000197 Walker B; other site 644284000198 D-loop; other site 644284000199 H-loop/switch region; other site 644284000200 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644284000201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284000202 Walker A/P-loop; other site 644284000203 ATP binding site [chemical binding]; other site 644284000204 Q-loop/lid; other site 644284000205 ABC transporter signature motif; other site 644284000206 Walker B; other site 644284000207 D-loop; other site 644284000208 H-loop/switch region; other site 644284000209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 644284000210 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284000211 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284000212 nucleotide binding site [chemical binding]; other site 644284000213 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 644284000214 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 644284000215 CutC family; Region: CutC; cl01218 644284000216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644284000217 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 644284000218 Probable Catalytic site; other site 644284000219 metal-binding site 644284000220 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 644284000221 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 644284000222 putative active site [active] 644284000223 catalytic site [active] 644284000224 putative metal binding site [ion binding]; other site 644284000225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284000226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000227 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 644284000228 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 644284000229 active site 644284000230 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 644284000231 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 644284000232 NAD binding site [chemical binding]; other site 644284000233 substrate binding site [chemical binding]; other site 644284000234 homodimer interface [polypeptide binding]; other site 644284000235 active site 644284000236 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 644284000237 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 644284000238 Walker A/P-loop; other site 644284000239 ATP binding site [chemical binding]; other site 644284000240 Q-loop/lid; other site 644284000241 ABC transporter signature motif; other site 644284000242 Walker B; other site 644284000243 D-loop; other site 644284000244 H-loop/switch region; other site 644284000245 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 644284000246 putative carbohydrate binding site [chemical binding]; other site 644284000247 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 644284000248 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 644284000249 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644284000250 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 644284000251 Probable Catalytic site; other site 644284000252 metal-binding site 644284000253 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644284000254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644284000255 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 644284000256 Ligand binding site; other site 644284000257 Putative Catalytic site; other site 644284000258 DXD motif; other site 644284000259 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 644284000260 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 644284000261 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644284000262 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 644284000263 Ligand binding site; other site 644284000264 Putative Catalytic site; other site 644284000265 DXD motif; other site 644284000266 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 644284000267 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 644284000268 active site 644284000269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 644284000270 active site 644284000271 LicD family; Region: LicD; pfam04991 644284000272 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644284000273 EamA-like transporter family; Region: EamA; cl17759 644284000274 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644284000275 non-specific DNA interactions [nucleotide binding]; other site 644284000276 DNA binding site [nucleotide binding] 644284000277 sequence specific DNA binding site [nucleotide binding]; other site 644284000278 putative cAMP binding site [chemical binding]; other site 644284000279 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 644284000280 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 644284000281 active site 644284000282 metal-binding site 644284000283 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 644284000284 thiamine kinase; Region: ycfN_thiK; TIGR02721 644284000285 active site 644284000286 ATP binding site [chemical binding]; other site 644284000287 substrate binding site [chemical binding]; other site 644284000288 dimer interface [polypeptide binding]; other site 644284000289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644284000290 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 644284000291 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 644284000292 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 644284000293 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 644284000294 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 644284000295 NADP binding site [chemical binding]; other site 644284000296 active site 644284000297 putative substrate binding site [chemical binding]; other site 644284000298 AAA domain; Region: AAA_21; pfam13304 644284000299 AAA domain; Region: AAA_21; pfam13304 644284000300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000301 Walker B; other site 644284000302 D-loop; other site 644284000303 H-loop/switch region; other site 644284000304 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 644284000305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284000306 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284000307 DNA-binding interface [nucleotide binding]; DNA binding site 644284000308 putative transposase OrfB; Reviewed; Region: PHA02517 644284000309 HTH-like domain; Region: HTH_21; pfam13276 644284000310 Integrase core domain; Region: rve; pfam00665 644284000311 Integrase core domain; Region: rve_3; pfam13683 644284000312 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 644284000313 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 644284000314 Ligand binding site; other site 644284000315 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 644284000316 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 644284000317 substrate binding site; other site 644284000318 tetramer interface; other site 644284000319 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 644284000320 EamA-like transporter family; Region: EamA; cl17759 644284000321 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 644284000322 active site 644284000323 Rhomboid family; Region: Rhomboid; pfam01694 644284000324 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 644284000325 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 644284000326 active site 644284000327 catalytic site [active] 644284000328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644284000329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644284000330 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644284000331 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644284000332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 644284000333 active site 644284000334 ATP binding site [chemical binding]; other site 644284000335 substrate binding site [chemical binding]; other site 644284000336 activation loop (A-loop); other site 644284000337 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284000338 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284000339 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 644284000340 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644284000341 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 644284000342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 644284000343 active site 644284000344 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 644284000345 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 644284000346 phosphopeptide binding site; other site 644284000347 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 644284000348 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 644284000349 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 644284000350 phosphopeptide binding site; other site 644284000351 Predicted membrane protein [Function unknown]; Region: COG2860 644284000352 UPF0126 domain; Region: UPF0126; pfam03458 644284000353 UPF0126 domain; Region: UPF0126; pfam03458 644284000354 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 644284000355 ADP-ribose binding site [chemical binding]; other site 644284000356 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 644284000357 RNA/DNA hybrid binding site [nucleotide binding]; other site 644284000358 active site 644284000359 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 644284000360 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644284000361 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 644284000362 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 644284000363 S-ribosylhomocysteinase; Provisional; Region: PRK02260 644284000364 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 644284000365 catalytic residues [active] 644284000366 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 644284000367 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 644284000368 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 644284000369 Class I ribonucleotide reductase; Region: RNR_I; cd01679 644284000370 active site 644284000371 dimer interface [polypeptide binding]; other site 644284000372 catalytic residues [active] 644284000373 effector binding site; other site 644284000374 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 644284000375 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 644284000376 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 644284000377 dimer interface [polypeptide binding]; other site 644284000378 putative radical transfer pathway; other site 644284000379 diiron center [ion binding]; other site 644284000380 tyrosyl radical; other site 644284000381 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 644284000382 Low molecular weight phosphatase family; Region: LMWPc; cd00115 644284000383 active site 644284000384 SprT homologues; Region: SprT; cl01182 644284000385 SprT-like family; Region: SprT-like; pfam10263 644284000386 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644284000387 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 644284000388 Walker A/P-loop; other site 644284000389 ATP binding site [chemical binding]; other site 644284000390 Q-loop/lid; other site 644284000391 ABC transporter signature motif; other site 644284000392 Walker B; other site 644284000393 D-loop; other site 644284000394 H-loop/switch region; other site 644284000395 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644284000396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000397 dimer interface [polypeptide binding]; other site 644284000398 conserved gate region; other site 644284000399 putative PBP binding loops; other site 644284000400 ABC-ATPase subunit interface; other site 644284000401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644284000402 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644284000403 substrate binding pocket [chemical binding]; other site 644284000404 membrane-bound complex binding site; other site 644284000405 hinge residues; other site 644284000406 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 644284000407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284000408 ATP binding site [chemical binding]; other site 644284000409 putative Mg++ binding site [ion binding]; other site 644284000410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284000411 nucleotide binding region [chemical binding]; other site 644284000412 ATP-binding site [chemical binding]; other site 644284000413 Helicase associated domain (HA2); Region: HA2; pfam04408 644284000414 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 644284000415 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 644284000416 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 644284000417 putative catalytic site [active] 644284000418 putative phosphate binding site [ion binding]; other site 644284000419 putative metal binding site [ion binding]; other site 644284000420 Uncharacterized conserved protein [Function unknown]; Region: COG4850 644284000421 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 644284000422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644284000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284000424 DNA-binding site [nucleotide binding]; DNA binding site 644284000425 UTRA domain; Region: UTRA; pfam07702 644284000426 phosphoglucomutase; Validated; Region: PRK07564 644284000427 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 644284000428 active site 644284000429 substrate binding site [chemical binding]; other site 644284000430 metal binding site [ion binding]; metal-binding site 644284000431 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 644284000432 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 644284000433 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644284000434 metal-binding site [ion binding] 644284000435 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644284000436 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644284000437 metal-binding site [ion binding] 644284000438 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644284000439 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 644284000440 Membrane protein of unknown function; Region: DUF360; pfam04020 644284000441 YwiC-like protein; Region: YwiC; pfam14256 644284000442 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 644284000443 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 644284000444 active site 644284000445 catalytic residue [active] 644284000446 dimer interface [polypeptide binding]; other site 644284000447 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 644284000448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644284000449 active site 644284000450 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284000451 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644284000452 intersubunit interface [polypeptide binding]; other site 644284000453 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644284000454 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644284000455 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284000456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284000457 ABC-ATPase subunit interface; other site 644284000458 dimer interface [polypeptide binding]; other site 644284000459 putative PBP binding regions; other site 644284000460 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284000461 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284000462 ABC-ATPase subunit interface; other site 644284000463 dimer interface [polypeptide binding]; other site 644284000464 putative PBP binding regions; other site 644284000465 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 644284000466 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 644284000467 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644284000468 FeoA domain; Region: FeoA; pfam04023 644284000469 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 644284000470 trimer interface [polypeptide binding]; other site 644284000471 active site 644284000472 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 644284000473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644284000474 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 644284000475 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 644284000476 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 644284000477 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 644284000478 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644284000479 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 644284000480 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 644284000481 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 644284000482 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 644284000483 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644284000484 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 644284000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000486 dimer interface [polypeptide binding]; other site 644284000487 conserved gate region; other site 644284000488 putative PBP binding loops; other site 644284000489 ABC-ATPase subunit interface; other site 644284000490 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644284000491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000492 dimer interface [polypeptide binding]; other site 644284000493 ABC-ATPase subunit interface; other site 644284000494 putative PBP binding loops; other site 644284000495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284000496 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 644284000497 Walker A/P-loop; other site 644284000498 ATP binding site [chemical binding]; other site 644284000499 Q-loop/lid; other site 644284000500 ABC transporter signature motif; other site 644284000501 Walker B; other site 644284000502 D-loop; other site 644284000503 H-loop/switch region; other site 644284000504 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 644284000505 active site 644284000506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644284000507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000508 dimer interface [polypeptide binding]; other site 644284000509 conserved gate region; other site 644284000510 putative PBP binding loops; other site 644284000511 ABC-ATPase subunit interface; other site 644284000512 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 644284000513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644284000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000515 putative PBP binding loops; other site 644284000516 dimer interface [polypeptide binding]; other site 644284000517 ABC-ATPase subunit interface; other site 644284000518 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644284000519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 644284000520 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 644284000521 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 644284000522 nucleotide binding site/active site [active] 644284000523 HIT family signature motif; other site 644284000524 catalytic residue [active] 644284000525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000526 putative substrate translocation pore; other site 644284000527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284000528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000529 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 644284000530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 644284000531 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644284000532 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 644284000533 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 644284000534 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 644284000535 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 644284000536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 644284000537 nucleotide binding site [chemical binding]; other site 644284000538 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 644284000539 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 644284000540 dimer interface [polypeptide binding]; other site 644284000541 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 644284000542 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 644284000543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644284000544 HSP70 interaction site [polypeptide binding]; other site 644284000545 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 644284000546 substrate binding site [polypeptide binding]; other site 644284000547 dimer interface [polypeptide binding]; other site 644284000548 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644284000549 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 644284000550 DNA binding residues [nucleotide binding] 644284000551 putative dimer interface [polypeptide binding]; other site 644284000552 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 644284000553 putative active site [active] 644284000554 putative CoA binding site [chemical binding]; other site 644284000555 nudix motif; other site 644284000556 metal binding site [ion binding]; metal-binding site 644284000557 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 644284000558 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 644284000559 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 644284000560 generic binding surface I; other site 644284000561 generic binding surface II; other site 644284000562 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 644284000563 putative active site [active] 644284000564 putative catalytic site [active] 644284000565 putative Mg binding site IVb [ion binding]; other site 644284000566 putative phosphate binding site [ion binding]; other site 644284000567 putative DNA binding site [nucleotide binding]; other site 644284000568 putative Mg binding site IVa [ion binding]; other site 644284000569 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 644284000570 putative deacylase active site [active] 644284000571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 644284000572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284000573 Coenzyme A binding pocket [chemical binding]; other site 644284000574 TspO/MBR family; Region: TspO_MBR; pfam03073 644284000575 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 644284000576 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 644284000577 active site 644284000578 HIGH motif; other site 644284000579 nucleotide binding site [chemical binding]; other site 644284000580 active site 644284000581 KMSKS motif; other site 644284000582 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 644284000583 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 644284000584 Clp amino terminal domain; Region: Clp_N; pfam02861 644284000585 Clp amino terminal domain; Region: Clp_N; pfam02861 644284000586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000587 Walker A motif; other site 644284000588 ATP binding site [chemical binding]; other site 644284000589 Walker B motif; other site 644284000590 arginine finger; other site 644284000591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000592 Walker A motif; other site 644284000593 ATP binding site [chemical binding]; other site 644284000594 Walker B motif; other site 644284000595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644284000596 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644284000597 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 644284000598 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 644284000599 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 644284000600 Beta-lactamase; Region: Beta-lactamase; pfam00144 644284000601 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 644284000602 putative catalytic site [active] 644284000603 putative phosphate binding site [ion binding]; other site 644284000604 active site 644284000605 metal binding site A [ion binding]; metal-binding site 644284000606 DNA binding site [nucleotide binding] 644284000607 putative AP binding site [nucleotide binding]; other site 644284000608 putative metal binding site B [ion binding]; other site 644284000609 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 644284000610 classical (c) SDRs; Region: SDR_c; cd05233 644284000611 NAD(P) binding site [chemical binding]; other site 644284000612 active site 644284000613 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 644284000614 active site 644284000615 8-oxo-dGMP binding site [chemical binding]; other site 644284000616 nudix motif; other site 644284000617 metal binding site [ion binding]; metal-binding site 644284000618 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644284000619 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 644284000620 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 644284000621 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 644284000622 active site 644284000623 intersubunit interface [polypeptide binding]; other site 644284000624 zinc binding site [ion binding]; other site 644284000625 Na+ binding site [ion binding]; other site 644284000626 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 644284000627 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 644284000628 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644284000629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 644284000630 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 644284000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000632 dimer interface [polypeptide binding]; other site 644284000633 conserved gate region; other site 644284000634 putative PBP binding loops; other site 644284000635 ABC-ATPase subunit interface; other site 644284000636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644284000637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000638 dimer interface [polypeptide binding]; other site 644284000639 conserved gate region; other site 644284000640 putative PBP binding loops; other site 644284000641 ABC-ATPase subunit interface; other site 644284000642 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 644284000643 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 644284000644 active site 644284000645 substrate-binding site [chemical binding]; other site 644284000646 metal-binding site [ion binding] 644284000647 GTP binding site [chemical binding]; other site 644284000648 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 644284000649 ATP binding site [chemical binding]; other site 644284000650 active site 644284000651 substrate binding site [chemical binding]; other site 644284000652 glutamate dehydrogenase; Provisional; Region: PRK09414 644284000653 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644284000654 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 644284000655 NAD(P) binding site [chemical binding]; other site 644284000656 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 644284000657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644284000658 active site 644284000659 metal binding site [ion binding]; metal-binding site 644284000660 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644284000661 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 644284000662 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 644284000663 DNA binding residues [nucleotide binding] 644284000664 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 644284000665 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 644284000666 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 644284000667 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 644284000668 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644284000669 methionine sulfoxide reductase B; Provisional; Region: PRK00222 644284000670 SelR domain; Region: SelR; pfam01641 644284000671 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 644284000672 putative catalytic site [active] 644284000673 putative metal binding site [ion binding]; other site 644284000674 putative phosphate binding site [ion binding]; other site 644284000675 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 644284000676 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644284000677 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644284000678 PBP superfamily domain; Region: PBP_like_2; cl17296 644284000679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000680 dimer interface [polypeptide binding]; other site 644284000681 conserved gate region; other site 644284000682 putative PBP binding loops; other site 644284000683 ABC-ATPase subunit interface; other site 644284000684 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 644284000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284000686 dimer interface [polypeptide binding]; other site 644284000687 conserved gate region; other site 644284000688 ABC-ATPase subunit interface; other site 644284000689 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 644284000690 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 644284000691 Walker A/P-loop; other site 644284000692 ATP binding site [chemical binding]; other site 644284000693 Q-loop/lid; other site 644284000694 ABC transporter signature motif; other site 644284000695 Walker B; other site 644284000696 D-loop; other site 644284000697 H-loop/switch region; other site 644284000698 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 644284000699 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 644284000700 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 644284000701 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 644284000702 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 644284000703 heme-binding site [chemical binding]; other site 644284000704 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 644284000705 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 644284000706 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 644284000707 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 644284000708 putative active site [active] 644284000709 dimerization interface [polypeptide binding]; other site 644284000710 putative tRNAtyr binding site [nucleotide binding]; other site 644284000711 Clp protease ATP binding subunit; Region: clpC; CHL00095 644284000712 Clp amino terminal domain; Region: Clp_N; pfam02861 644284000713 Clp amino terminal domain; Region: Clp_N; pfam02861 644284000714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000715 Walker A motif; other site 644284000716 ATP binding site [chemical binding]; other site 644284000717 Walker B motif; other site 644284000718 arginine finger; other site 644284000719 UvrB/uvrC motif; Region: UVR; pfam02151 644284000720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000721 Walker A motif; other site 644284000722 ATP binding site [chemical binding]; other site 644284000723 Walker B motif; other site 644284000724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 644284000725 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 644284000726 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 644284000727 active site 644284000728 catalytic site [active] 644284000729 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644284000730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644284000731 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644284000732 Predicted permease [General function prediction only]; Region: COG2056 644284000733 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 644284000734 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 644284000735 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644284000736 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 644284000737 active site 644284000738 metal binding site [ion binding]; metal-binding site 644284000739 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 644284000740 pyruvate phosphate dikinase; Provisional; Region: PRK09279 644284000741 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 644284000742 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644284000743 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644284000744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644284000745 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 644284000746 catalytic triad [active] 644284000747 catalytic triad [active] 644284000748 oxyanion hole [active] 644284000749 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644284000750 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 644284000751 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 644284000752 active site 644284000753 catalytic triad [active] 644284000754 oxyanion hole [active] 644284000755 von Willebrand factor type A domain; Region: VWA_2; pfam13519 644284000756 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 644284000757 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644284000758 NlpC/P60 family; Region: NLPC_P60; pfam00877 644284000759 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 644284000760 dimer interface [polypeptide binding]; other site 644284000761 substrate binding site [chemical binding]; other site 644284000762 metal binding sites [ion binding]; metal-binding site 644284000763 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 644284000764 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 644284000765 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 644284000766 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 644284000767 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 644284000768 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 644284000769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284000770 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644284000771 Walker A motif; other site 644284000772 ATP binding site [chemical binding]; other site 644284000773 Walker B motif; other site 644284000774 arginine finger; other site 644284000775 Peptidase family M41; Region: Peptidase_M41; pfam01434 644284000776 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 644284000777 GTP cyclohydrolase I; Provisional; Region: PLN03044 644284000778 homodecamer interface [polypeptide binding]; other site 644284000779 active site 644284000780 putative catalytic site residues [active] 644284000781 zinc binding site [ion binding]; other site 644284000782 GTP-CH-I/GFRP interaction surface; other site 644284000783 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 644284000784 dihydropteroate synthase; Region: DHPS; TIGR01496 644284000785 substrate binding pocket [chemical binding]; other site 644284000786 dimer interface [polypeptide binding]; other site 644284000787 inhibitor binding site; inhibition site 644284000788 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 644284000789 homooctamer interface [polypeptide binding]; other site 644284000790 active site 644284000791 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 644284000792 catalytic center binding site [active] 644284000793 ATP binding site [chemical binding]; other site 644284000794 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 644284000795 Uncharacterized conserved protein [Function unknown]; Region: COG3402 644284000796 Predicted membrane protein [Function unknown]; Region: COG3428 644284000797 Bacterial PH domain; Region: DUF304; pfam03703 644284000798 Bacterial PH domain; Region: DUF304; cl01348 644284000799 Bacterial PH domain; Region: DUF304; pfam03703 644284000800 Rossmann-like domain; Region: Rossmann-like; pfam10727 644284000801 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 644284000802 pantoate--beta-alanine ligase; Region: panC; TIGR00018 644284000803 Pantoate-beta-alanine ligase; Region: PanC; cd00560 644284000804 active site 644284000805 ATP-binding site [chemical binding]; other site 644284000806 pantoate-binding site; other site 644284000807 HXXH motif; other site 644284000808 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 644284000809 tetramerization interface [polypeptide binding]; other site 644284000810 active site 644284000811 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 644284000812 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 644284000813 dimer interface [polypeptide binding]; other site 644284000814 putative anticodon binding site; other site 644284000815 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644284000816 motif 1; other site 644284000817 dimer interface [polypeptide binding]; other site 644284000818 active site 644284000819 motif 2; other site 644284000820 motif 3; other site 644284000821 glycerol kinase; Provisional; Region: glpK; PRK00047 644284000822 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 644284000823 N- and C-terminal domain interface [polypeptide binding]; other site 644284000824 active site 644284000825 MgATP binding site [chemical binding]; other site 644284000826 catalytic site [active] 644284000827 metal binding site [ion binding]; metal-binding site 644284000828 putative homotetramer interface [polypeptide binding]; other site 644284000829 glycerol binding site [chemical binding]; other site 644284000830 homodimer interface [polypeptide binding]; other site 644284000831 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 644284000832 amphipathic channel; other site 644284000833 Asn-Pro-Ala signature motifs; other site 644284000834 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 644284000835 active site 644284000836 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 644284000837 Cysteine-rich domain; Region: CCG; pfam02754 644284000838 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 644284000839 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 644284000840 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 644284000841 hydroxyglutarate oxidase; Provisional; Region: PRK11728 644284000842 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 644284000843 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 644284000844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644284000845 DNA binding residues [nucleotide binding] 644284000846 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 644284000847 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 644284000848 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644284000849 minor groove reading motif; other site 644284000850 helix-hairpin-helix signature motif; other site 644284000851 substrate binding pocket [chemical binding]; other site 644284000852 active site 644284000853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284000854 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284000855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000856 putative substrate translocation pore; other site 644284000857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000858 metabolite-proton symporter; Region: 2A0106; TIGR00883 644284000859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284000860 putative substrate translocation pore; other site 644284000861 Predicted ATPase [General function prediction only]; Region: COG4637 644284000862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000863 Walker A/P-loop; other site 644284000864 ATP binding site [chemical binding]; other site 644284000865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000866 ABC transporter signature motif; other site 644284000867 Walker B; other site 644284000868 D-loop; other site 644284000869 H-loop/switch region; other site 644284000870 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 644284000871 DNA repair protein RadA; Provisional; Region: PRK11823 644284000872 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644284000873 Walker A motif; other site 644284000874 ATP binding site [chemical binding]; other site 644284000875 Walker B motif; other site 644284000876 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 644284000877 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644284000878 TrkA-N domain; Region: TrkA_N; pfam02254 644284000879 TrkA-C domain; Region: TrkA_C; pfam02080 644284000880 Cation transport protein; Region: TrkH; cl17365 644284000881 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 644284000882 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 644284000883 DNA binding domain, excisionase family; Region: excise; TIGR01764 644284000884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644284000885 MarR family; Region: MarR_2; pfam12802 644284000886 MarR family; Region: MarR_2; cl17246 644284000887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644284000888 catalytic core [active] 644284000889 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 644284000890 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 644284000891 UbiA prenyltransferase family; Region: UbiA; pfam01040 644284000892 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 644284000893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644284000894 active site 644284000895 CoA binding site [chemical binding]; other site 644284000896 AMP binding site [chemical binding]; other site 644284000897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644284000898 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 644284000899 substrate binding site [chemical binding]; other site 644284000900 oxyanion hole (OAH) forming residues; other site 644284000901 trimer interface [polypeptide binding]; other site 644284000902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284000903 S-adenosylmethionine binding site [chemical binding]; other site 644284000904 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 644284000905 O-succinylbenzoate synthase; Provisional; Region: PRK05105 644284000906 active site 644284000907 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 644284000908 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 644284000909 PYR/PP interface [polypeptide binding]; other site 644284000910 dimer interface [polypeptide binding]; other site 644284000911 TPP binding site [chemical binding]; other site 644284000912 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 644284000913 TPP-binding site [chemical binding]; other site 644284000914 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 644284000915 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644284000916 protein binding site [polypeptide binding]; other site 644284000917 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 644284000918 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 644284000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284000920 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 644284000921 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 644284000922 NADH dehydrogenase subunit B; Validated; Region: PRK06411 644284000923 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 644284000924 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 644284000925 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 644284000926 NADH dehydrogenase subunit D; Validated; Region: PRK06075 644284000927 NADH dehydrogenase subunit E; Validated; Region: PRK07539 644284000928 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 644284000929 putative dimer interface [polypeptide binding]; other site 644284000930 [2Fe-2S] cluster binding site [ion binding]; other site 644284000931 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 644284000932 SLBB domain; Region: SLBB; pfam10531 644284000933 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 644284000934 NADH dehydrogenase subunit G; Validated; Region: PRK07860 644284000935 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644284000936 catalytic loop [active] 644284000937 iron binding site [ion binding]; other site 644284000938 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 644284000939 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 644284000940 molybdopterin cofactor binding site; other site 644284000941 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 644284000942 molybdopterin cofactor binding site; other site 644284000943 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 644284000944 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 644284000945 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 644284000946 4Fe-4S binding domain; Region: Fer4; pfam00037 644284000947 4Fe-4S binding domain; Region: Fer4; pfam00037 644284000948 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 644284000949 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 644284000950 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 644284000951 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 644284000952 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 644284000953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644284000954 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 644284000955 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644284000956 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 644284000957 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 644284000958 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644284000959 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644284000960 substrate binding pocket [chemical binding]; other site 644284000961 chain length determination region; other site 644284000962 substrate-Mg2+ binding site; other site 644284000963 catalytic residues [active] 644284000964 aspartate-rich region 1; other site 644284000965 active site lid residues [active] 644284000966 aspartate-rich region 2; other site 644284000967 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 644284000968 DEAD/DEAH box helicase; Region: DEAD; pfam00270 644284000969 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 644284000970 TRAM domain; Region: TRAM; pfam01938 644284000971 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 644284000972 Methyltransferase domain; Region: Methyltransf_26; pfam13659 644284000973 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 644284000974 oligomeric interface; other site 644284000975 putative active site [active] 644284000976 homodimer interface [polypeptide binding]; other site 644284000977 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 644284000978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 644284000979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644284000980 Helix-turn-helix domain; Region: HTH_17; pfam12728 644284000981 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 644284000982 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 644284000983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000984 Walker A/P-loop; other site 644284000985 ATP binding site [chemical binding]; other site 644284000986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284000987 ABC transporter signature motif; other site 644284000988 Walker B; other site 644284000989 D-loop; other site 644284000990 H-loop/switch region; other site 644284000991 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 644284000992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644284000993 active site 644284000994 metal binding site [ion binding]; metal-binding site 644284000995 DNA binding site [nucleotide binding] 644284000996 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 644284000997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 644284000998 PAS domain; Region: PAS_9; pfam13426 644284000999 putative active site [active] 644284001000 heme pocket [chemical binding]; other site 644284001001 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 644284001002 ribosome small subunit-dependent GTPase A; Region: TIGR00157 644284001003 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644284001004 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644284001005 GTP/Mg2+ binding site [chemical binding]; other site 644284001006 G4 box; other site 644284001007 G5 box; other site 644284001008 G1 box; other site 644284001009 Switch I region; other site 644284001010 G2 box; other site 644284001011 G3 box; other site 644284001012 Switch II region; other site 644284001013 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 644284001014 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 644284001015 hinge; other site 644284001016 active site 644284001017 Transcriptional regulators [Transcription]; Region: GntR; COG1802 644284001018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284001019 DNA-binding site [nucleotide binding]; DNA binding site 644284001020 FCD domain; Region: FCD; pfam07729 644284001021 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284001022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284001023 nucleotide binding site [chemical binding]; other site 644284001024 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 644284001025 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 644284001026 putative active site cavity [active] 644284001027 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 644284001028 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 644284001029 active site 644284001030 trimer interface [polypeptide binding]; other site 644284001031 allosteric site; other site 644284001032 active site lid [active] 644284001033 hexamer (dimer of trimers) interface [polypeptide binding]; other site 644284001034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644284001035 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 644284001036 active site 644284001037 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 644284001038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644284001039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644284001040 DNA binding residues [nucleotide binding] 644284001041 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 644284001042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 644284001043 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 644284001044 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 644284001045 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 644284001046 putative active site [active] 644284001047 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 644284001048 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 644284001049 active site 644284001050 catalytic triad [active] 644284001051 oxyanion hole [active] 644284001052 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 644284001053 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 644284001054 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 644284001055 TPP-binding site [chemical binding]; other site 644284001056 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 644284001057 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 644284001058 Domain of unknown function DUF21; Region: DUF21; pfam01595 644284001059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644284001060 Transporter associated domain; Region: CorC_HlyC; smart01091 644284001061 Domain of unknown function DUF21; Region: DUF21; pfam01595 644284001062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644284001063 FOG: CBS domain [General function prediction only]; Region: COG0517 644284001064 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 644284001065 Peptidase family M23; Region: Peptidase_M23; pfam01551 644284001066 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 644284001067 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 644284001068 putative active site [active] 644284001069 catalytic site [active] 644284001070 putative metal binding site [ion binding]; other site 644284001071 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 644284001072 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 644284001073 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 644284001074 active site 644284001075 HIGH motif; other site 644284001076 KMSK motif region; other site 644284001077 tRNA binding surface [nucleotide binding]; other site 644284001078 DALR anticodon binding domain; Region: DALR_1; smart00836 644284001079 anticodon binding site; other site 644284001080 homoserine kinase; Provisional; Region: PRK01212 644284001081 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cl06998 644284001082 transcription termination factor Rho; Provisional; Region: PRK12608 644284001083 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644284001084 RNA binding site [nucleotide binding]; other site 644284001085 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 644284001086 multimer interface [polypeptide binding]; other site 644284001087 Walker A motif; other site 644284001088 ATP binding site [chemical binding]; other site 644284001089 Walker B motif; other site 644284001090 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 644284001091 peptide chain release factor 1; Validated; Region: prfA; PRK00591 644284001092 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644284001093 RF-1 domain; Region: RF-1; pfam00472 644284001094 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 644284001095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284001096 S-adenosylmethionine binding site [chemical binding]; other site 644284001097 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 644284001098 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 644284001099 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 644284001100 Mg++ binding site [ion binding]; other site 644284001101 putative catalytic motif [active] 644284001102 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 644284001103 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 644284001104 ATP synthase subunit C; Region: ATP-synt_C; cl00466 644284001105 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 644284001106 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 644284001107 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 644284001108 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 644284001109 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 644284001110 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644284001111 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 644284001112 beta subunit interaction interface [polypeptide binding]; other site 644284001113 Walker A motif; other site 644284001114 ATP binding site [chemical binding]; other site 644284001115 Walker B motif; other site 644284001116 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644284001117 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 644284001118 core domain interface [polypeptide binding]; other site 644284001119 delta subunit interface [polypeptide binding]; other site 644284001120 epsilon subunit interface [polypeptide binding]; other site 644284001121 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 644284001122 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 644284001123 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 644284001124 alpha subunit interaction interface [polypeptide binding]; other site 644284001125 Walker A motif; other site 644284001126 ATP binding site [chemical binding]; other site 644284001127 Walker B motif; other site 644284001128 inhibitor binding site; inhibition site 644284001129 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644284001130 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 644284001131 gamma subunit interface [polypeptide binding]; other site 644284001132 LBP interface [polypeptide binding]; other site 644284001133 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 644284001134 hypothetical protein; Provisional; Region: PRK03298 644284001135 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644284001136 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 644284001137 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 644284001138 DivIVA protein; Region: DivIVA; pfam05103 644284001139 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 644284001140 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 644284001141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644284001142 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 644284001143 active site 644284001144 catalytic site [active] 644284001145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284001146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284001147 DNA binding site [nucleotide binding] 644284001148 domain linker motif; other site 644284001149 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 644284001150 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 644284001151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 644284001152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001153 dimer interface [polypeptide binding]; other site 644284001154 conserved gate region; other site 644284001155 putative PBP binding loops; other site 644284001156 ABC-ATPase subunit interface; other site 644284001157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644284001158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001159 dimer interface [polypeptide binding]; other site 644284001160 conserved gate region; other site 644284001161 putative PBP binding loops; other site 644284001162 ABC-ATPase subunit interface; other site 644284001163 Predicted flavoprotein [General function prediction only]; Region: COG0431 644284001164 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644284001165 glycogen branching enzyme; Provisional; Region: PRK05402 644284001166 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 644284001167 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 644284001168 active site 644284001169 catalytic site [active] 644284001170 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 644284001171 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 644284001172 trehalose synthase; Region: treS_nterm; TIGR02456 644284001173 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 644284001174 active site 644284001175 catalytic site [active] 644284001176 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 644284001177 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 644284001178 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 644284001179 active site 644284001180 catalytic site [active] 644284001181 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 644284001182 active site 644284001183 DNA binding site [nucleotide binding] 644284001184 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 644284001185 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 644284001186 active site pocket [active] 644284001187 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 644284001188 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 644284001189 active site 644284001190 HIGH motif; other site 644284001191 dimer interface [polypeptide binding]; other site 644284001192 KMSKS motif; other site 644284001193 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 644284001194 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 644284001195 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 644284001196 active site 644284001197 catalytic site [active] 644284001198 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 644284001199 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 644284001200 putative NADH binding site [chemical binding]; other site 644284001201 putative active site [active] 644284001202 nudix motif; other site 644284001203 putative metal binding site [ion binding]; other site 644284001204 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 644284001205 Part of AAA domain; Region: AAA_19; pfam13245 644284001206 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 644284001207 Family description; Region: UvrD_C_2; pfam13538 644284001208 HRDC domain; Region: HRDC; pfam00570 644284001209 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 644284001210 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 644284001211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644284001212 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 644284001213 Uncharacterized conserved protein [Function unknown]; Region: COG1615 644284001214 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 644284001215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001216 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284001217 Walker A/P-loop; other site 644284001218 ATP binding site [chemical binding]; other site 644284001219 Q-loop/lid; other site 644284001220 ABC transporter signature motif; other site 644284001221 Walker B; other site 644284001222 D-loop; other site 644284001223 H-loop/switch region; other site 644284001224 Predicted transcriptional regulators [Transcription]; Region: COG1725 644284001225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284001226 DNA-binding site [nucleotide binding]; DNA binding site 644284001227 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 644284001228 Predicted transcriptional regulators [Transcription]; Region: COG1695 644284001229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 644284001230 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001231 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644284001232 Walker A/P-loop; other site 644284001233 ATP binding site [chemical binding]; other site 644284001234 Q-loop/lid; other site 644284001235 ABC transporter signature motif; other site 644284001236 Walker B; other site 644284001237 D-loop; other site 644284001238 H-loop/switch region; other site 644284001239 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 644284001240 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 644284001241 GTP binding site; other site 644284001242 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 644284001243 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 644284001244 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 644284001245 folate binding site [chemical binding]; other site 644284001246 NADP+ binding site [chemical binding]; other site 644284001247 thymidylate synthase; Reviewed; Region: thyA; PRK01827 644284001248 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 644284001249 dimerization interface [polypeptide binding]; other site 644284001250 active site 644284001251 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 644284001252 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 644284001253 PAS fold; Region: PAS_4; pfam08448 644284001254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 644284001255 Histidine kinase; Region: HisKA_2; pfam07568 644284001256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284001257 ATP binding site [chemical binding]; other site 644284001258 Mg2+ binding site [ion binding]; other site 644284001259 G-X-G motif; other site 644284001260 Transcription factor WhiB; Region: Whib; pfam02467 644284001261 FtsX-like permease family; Region: FtsX; pfam02687 644284001262 FtsX-like permease family; Region: FtsX; pfam02687 644284001263 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644284001264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001266 Walker A/P-loop; other site 644284001267 ATP binding site [chemical binding]; other site 644284001268 Q-loop/lid; other site 644284001269 ABC transporter signature motif; other site 644284001270 Walker B; other site 644284001271 D-loop; other site 644284001272 H-loop/switch region; other site 644284001273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284001274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284001275 active site 644284001276 phosphorylation site [posttranslational modification] 644284001277 intermolecular recognition site; other site 644284001278 dimerization interface [polypeptide binding]; other site 644284001279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284001280 DNA binding residues [nucleotide binding] 644284001281 dimerization interface [polypeptide binding]; other site 644284001282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644284001283 Histidine kinase; Region: HisKA_3; pfam07730 644284001284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284001285 ATP binding site [chemical binding]; other site 644284001286 Mg2+ binding site [ion binding]; other site 644284001287 G-X-G motif; other site 644284001288 Ligase N family; Region: LIGANc; smart00532 644284001289 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 644284001290 nucleotide binding pocket [chemical binding]; other site 644284001291 K-X-D-G motif; other site 644284001292 catalytic site [active] 644284001293 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 644284001294 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 644284001295 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 644284001296 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 644284001297 Dimer interface [polypeptide binding]; other site 644284001298 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 644284001299 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 644284001300 putative active site [active] 644284001301 catalytic site [active] 644284001302 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 644284001303 putative active site [active] 644284001304 catalytic site [active] 644284001305 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 644284001306 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 644284001307 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 644284001308 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 644284001309 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 644284001310 GatB domain; Region: GatB_Yqey; smart00845 644284001311 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644284001312 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 644284001313 Malic enzyme, N-terminal domain; Region: malic; pfam00390 644284001314 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 644284001315 putative NAD(P) binding site [chemical binding]; other site 644284001316 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 644284001317 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 644284001318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284001319 S-adenosylmethionine binding site [chemical binding]; other site 644284001320 Uncharacterized conserved protein [Function unknown]; Region: COG2966 644284001321 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 644284001322 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 644284001323 Predicted permease [General function prediction only]; Region: COG2985 644284001324 TrkA-C domain; Region: TrkA_C; pfam02080 644284001325 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 644284001326 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 644284001327 Aspartase; Region: Aspartase; cd01357 644284001328 active sites [active] 644284001329 tetramer interface [polypeptide binding]; other site 644284001330 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 644284001331 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 644284001332 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 644284001333 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 644284001334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284001335 FeS/SAM binding site; other site 644284001336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 644284001337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644284001338 catalytic residue [active] 644284001339 Superfamily II helicase [General function prediction only]; Region: COG1204 644284001340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284001341 ATP binding site [chemical binding]; other site 644284001342 putative Mg++ binding site [ion binding]; other site 644284001343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284001344 nucleotide binding region [chemical binding]; other site 644284001345 ATP-binding site [chemical binding]; other site 644284001346 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 644284001347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284001348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284001349 DNA binding site [nucleotide binding] 644284001350 domain linker motif; other site 644284001351 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644284001352 ligand binding site [chemical binding]; other site 644284001353 dimerization interface [polypeptide binding]; other site 644284001354 glucuronate isomerase; Reviewed; Region: PRK02925 644284001355 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 644284001356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644284001357 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 644284001358 substrate binding site [chemical binding]; other site 644284001359 ATP binding site [chemical binding]; other site 644284001360 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 644284001361 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 644284001362 active site 644284001363 intersubunit interface [polypeptide binding]; other site 644284001364 catalytic residue [active] 644284001365 mannonate dehydratase; Provisional; Region: PRK03906 644284001366 mannonate dehydratase; Region: uxuA; TIGR00695 644284001367 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 644284001368 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 644284001369 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 644284001370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644284001371 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 644284001372 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 644284001373 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644284001374 E3 interaction surface; other site 644284001375 lipoyl attachment site [posttranslational modification]; other site 644284001376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001377 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644284001378 Walker A/P-loop; other site 644284001379 ATP binding site [chemical binding]; other site 644284001380 Q-loop/lid; other site 644284001381 ABC transporter signature motif; other site 644284001382 Walker B; other site 644284001383 D-loop; other site 644284001384 H-loop/switch region; other site 644284001385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644284001386 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644284001387 FtsX-like permease family; Region: FtsX; pfam02687 644284001388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644284001389 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 644284001390 catalytic site [active] 644284001391 putative active site [active] 644284001392 putative substrate binding site [chemical binding]; other site 644284001393 dimer interface [polypeptide binding]; other site 644284001394 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 644284001395 G1 box; other site 644284001396 GTP/Mg2+ binding site [chemical binding]; other site 644284001397 G2 box; other site 644284001398 Switch I region; other site 644284001399 G3 box; other site 644284001400 Switch II region; other site 644284001401 G4 box; other site 644284001402 Dynamin family; Region: Dynamin_N; pfam00350 644284001403 YfjP GTPase; Region: YfjP; cd11383 644284001404 G1 box; other site 644284001405 GTP/Mg2+ binding site [chemical binding]; other site 644284001406 Switch I region; other site 644284001407 G2 box; other site 644284001408 Switch II region; other site 644284001409 G3 box; other site 644284001410 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 644284001411 G4 box; other site 644284001412 G4 box; other site 644284001413 G5 box; other site 644284001414 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644284001415 dimer interface [polypeptide binding]; other site 644284001416 ssDNA binding site [nucleotide binding]; other site 644284001417 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644284001418 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644284001419 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 644284001420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001421 Walker A/P-loop; other site 644284001422 ATP binding site [chemical binding]; other site 644284001423 Q-loop/lid; other site 644284001424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284001425 ABC transporter; Region: ABC_tran_2; pfam12848 644284001426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284001427 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644284001428 Domain of unknown function (DUF955); Region: DUF955; cl01076 644284001429 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 644284001430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644284001431 active site 644284001432 TQXA domain; Region: TQXA_dom; TIGR03934 644284001433 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 644284001434 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 644284001435 nudix motif; other site 644284001436 RelB antitoxin; Region: RelB; cl01171 644284001437 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 644284001438 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 644284001439 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 644284001440 active site 644284001441 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 644284001442 catalytic triad [active] 644284001443 dimer interface [polypeptide binding]; other site 644284001444 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 644284001445 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 644284001446 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 644284001447 active site turn [active] 644284001448 phosphorylation site [posttranslational modification] 644284001449 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644284001450 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 644284001451 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 644284001452 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 644284001453 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 644284001454 Zn binding site [ion binding]; other site 644284001455 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 644284001456 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 644284001457 active site 644284001458 Zn binding site [ion binding]; other site 644284001459 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 644284001460 serine O-acetyltransferase; Region: cysE; TIGR01172 644284001461 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 644284001462 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 644284001463 trimer interface [polypeptide binding]; other site 644284001464 active site 644284001465 substrate binding site [chemical binding]; other site 644284001466 CoA binding site [chemical binding]; other site 644284001467 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 644284001468 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 644284001469 dimer interface [polypeptide binding]; other site 644284001470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644284001471 catalytic residue [active] 644284001472 Uncharacterized conserved protein [Function unknown]; Region: COG1739 644284001473 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 644284001474 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 644284001475 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 644284001476 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 644284001477 Asp-box motif; other site 644284001478 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284001479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284001480 ABC-ATPase subunit interface; other site 644284001481 dimer interface [polypeptide binding]; other site 644284001482 putative PBP binding regions; other site 644284001483 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644284001484 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 644284001485 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284001486 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284001487 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 644284001488 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284001489 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284001490 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 644284001491 Carbon starvation protein CstA; Region: CstA; pfam02554 644284001492 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 644284001493 Protein of unknown function (DUF466); Region: DUF466; pfam04328 644284001494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644284001495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644284001496 active site 644284001497 catalytic tetrad [active] 644284001498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284001499 putative DNA binding site [nucleotide binding]; other site 644284001500 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 644284001501 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 644284001502 Substrate-binding site [chemical binding]; other site 644284001503 Substrate specificity [chemical binding]; other site 644284001504 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 644284001505 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 644284001506 gating phenylalanine in ion channel; other site 644284001507 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 644284001508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644284001509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 644284001510 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644284001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001512 dimer interface [polypeptide binding]; other site 644284001513 conserved gate region; other site 644284001514 putative PBP binding loops; other site 644284001515 ABC-ATPase subunit interface; other site 644284001516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644284001517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001518 dimer interface [polypeptide binding]; other site 644284001519 conserved gate region; other site 644284001520 putative PBP binding loops; other site 644284001521 ABC-ATPase subunit interface; other site 644284001522 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 644284001523 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 644284001524 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 644284001525 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 644284001526 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 644284001527 putative transposase OrfB; Reviewed; Region: PHA02517 644284001528 HTH-like domain; Region: HTH_21; pfam13276 644284001529 Integrase core domain; Region: rve; pfam00665 644284001530 Integrase core domain; Region: rve_3; pfam13683 644284001531 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 644284001532 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644284001533 active site 644284001534 Phage terminase, small subunit; Region: Terminase_4; cl01525 644284001535 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 644284001536 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 644284001537 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 644284001538 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 644284001539 ParB-like nuclease domain; Region: ParBc; pfam02195 644284001540 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 644284001541 DNA methylase; Region: N6_N4_Mtase; cl17433 644284001542 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 644284001543 Phage-related protein [Function unknown]; Region: COG4695; cl01923 644284001544 Phage portal protein; Region: Phage_portal; pfam04860 644284001545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284001546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284001547 active site 644284001548 phosphorylation site [posttranslational modification] 644284001549 intermolecular recognition site; other site 644284001550 dimerization interface [polypeptide binding]; other site 644284001551 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 644284001552 dimerization interface [polypeptide binding]; other site 644284001553 DNA binding residues [nucleotide binding] 644284001554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644284001555 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 644284001556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284001557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284001558 active site 644284001559 phosphorylation site [posttranslational modification] 644284001560 intermolecular recognition site; other site 644284001561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284001562 DNA binding residues [nucleotide binding] 644284001563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644284001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284001565 ATP binding site [chemical binding]; other site 644284001566 Mg2+ binding site [ion binding]; other site 644284001567 G-X-G motif; other site 644284001568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001569 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644284001570 Walker A/P-loop; other site 644284001571 ATP binding site [chemical binding]; other site 644284001572 Q-loop/lid; other site 644284001573 ABC transporter signature motif; other site 644284001574 Walker B; other site 644284001575 D-loop; other site 644284001576 H-loop/switch region; other site 644284001577 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 644284001578 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 644284001579 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 644284001580 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 644284001581 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 644284001582 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 644284001583 trigger factor; Provisional; Region: tig; PRK01490 644284001584 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644284001585 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 644284001586 Clp protease; Region: CLP_protease; pfam00574 644284001587 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644284001588 oligomer interface [polypeptide binding]; other site 644284001589 active site residues [active] 644284001590 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 644284001591 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644284001592 oligomer interface [polypeptide binding]; other site 644284001593 active site residues [active] 644284001594 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 644284001595 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 644284001596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284001597 Walker A motif; other site 644284001598 ATP binding site [chemical binding]; other site 644284001599 Walker B motif; other site 644284001600 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 644284001601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284001602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284001603 DNA binding site [nucleotide binding] 644284001604 domain linker motif; other site 644284001605 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644284001606 dimerization interface [polypeptide binding]; other site 644284001607 ligand binding site [chemical binding]; other site 644284001608 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 644284001609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284001610 putative substrate translocation pore; other site 644284001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284001612 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 644284001613 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 644284001614 active site 644284001615 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 644284001616 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 644284001617 acyl-activating enzyme (AAE) consensus motif; other site 644284001618 putative AMP binding site [chemical binding]; other site 644284001619 putative active site [active] 644284001620 putative CoA binding site [chemical binding]; other site 644284001621 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 644284001622 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284001623 active site 644284001624 HIGH motif; other site 644284001625 nucleotide binding site [chemical binding]; other site 644284001626 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284001627 active site 644284001628 KMSKS motif; other site 644284001629 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 644284001630 tRNA binding surface [nucleotide binding]; other site 644284001631 anticodon binding site; other site 644284001632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284001633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001634 Walker A/P-loop; other site 644284001635 ATP binding site [chemical binding]; other site 644284001636 Q-loop/lid; other site 644284001637 ABC transporter signature motif; other site 644284001638 Walker B; other site 644284001639 D-loop; other site 644284001640 H-loop/switch region; other site 644284001641 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284001642 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001644 Walker A/P-loop; other site 644284001645 ATP binding site [chemical binding]; other site 644284001646 Q-loop/lid; other site 644284001647 ABC transporter signature motif; other site 644284001648 Walker B; other site 644284001649 D-loop; other site 644284001650 H-loop/switch region; other site 644284001651 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 644284001652 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 644284001653 HIGH motif; other site 644284001654 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 644284001655 active site 644284001656 KMSKS motif; other site 644284001657 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 644284001658 tRNA binding surface [nucleotide binding]; other site 644284001659 anticodon binding site; other site 644284001660 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 644284001661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284001662 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644284001663 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 644284001664 active site 644284001665 multimer interface [polypeptide binding]; other site 644284001666 DAK2 domain; Region: Dak2; cl03685 644284001667 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 644284001668 AAA domain; Region: AAA_23; pfam13476 644284001669 Walker A/P-loop; other site 644284001670 ATP binding site [chemical binding]; other site 644284001671 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 644284001672 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 644284001673 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 644284001674 ABC transporter signature motif; other site 644284001675 Walker B; other site 644284001676 D-loop; other site 644284001677 H-loop/switch region; other site 644284001678 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 644284001679 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 644284001680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 644284001681 signal recognition particle protein; Provisional; Region: PRK10867 644284001682 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 644284001683 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644284001684 P loop; other site 644284001685 GTP binding site [chemical binding]; other site 644284001686 Signal peptide binding domain; Region: SRP_SPB; pfam02978 644284001687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644284001688 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 644284001689 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644284001690 active site 644284001691 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 644284001692 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 644284001693 Cation efflux family; Region: Cation_efflux; cl00316 644284001694 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 644284001695 hypothetical protein; Provisional; Region: PRK02821 644284001696 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 644284001697 G-X-X-G motif; other site 644284001698 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 644284001699 RimM N-terminal domain; Region: RimM; pfam01782 644284001700 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 644284001701 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644284001702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284001703 Coenzyme A binding pocket [chemical binding]; other site 644284001704 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 644284001705 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 644284001706 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644284001707 Catalytic site [active] 644284001708 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 644284001709 RNA/DNA hybrid binding site [nucleotide binding]; other site 644284001710 active site 644284001711 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 644284001712 hypothetical protein; Reviewed; Region: PRK12497 644284001713 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 644284001714 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 644284001715 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 644284001716 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 644284001717 DNA protecting protein DprA; Region: dprA; TIGR00732 644284001718 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 644284001719 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 644284001720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644284001721 active site 644284001722 DNA binding site [nucleotide binding] 644284001723 Int/Topo IB signature motif; other site 644284001724 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 644284001725 active site 644284001726 catalytic triad [active] 644284001727 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 644284001728 Peptidase family M23; Region: Peptidase_M23; pfam01551 644284001729 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 644284001730 rRNA interaction site [nucleotide binding]; other site 644284001731 S8 interaction site; other site 644284001732 putative laminin-1 binding site; other site 644284001733 elongation factor Ts; Provisional; Region: tsf; PRK09377 644284001734 Elongation factor TS; Region: EF_TS; pfam00889 644284001735 Elongation factor TS; Region: EF_TS; pfam00889 644284001736 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 644284001737 Ligand Binding Site [chemical binding]; other site 644284001738 Electron transfer flavoprotein domain; Region: ETF; pfam01012 644284001739 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 644284001740 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 644284001741 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 644284001742 oxidoreductase; Provisional; Region: PRK10015 644284001743 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 644284001744 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 644284001745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284001747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644284001748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284001749 non-specific DNA binding site [nucleotide binding]; other site 644284001750 salt bridge; other site 644284001751 sequence-specific DNA binding site [nucleotide binding]; other site 644284001752 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284001753 RNA binding surface [nucleotide binding]; other site 644284001754 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 644284001755 putative nucleotide binding site [chemical binding]; other site 644284001756 uridine monophosphate binding site [chemical binding]; other site 644284001757 homohexameric interface [polypeptide binding]; other site 644284001758 ribosome recycling factor; Reviewed; Region: frr; PRK00083 644284001759 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 644284001760 hinge region; other site 644284001761 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 644284001762 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 644284001763 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 644284001764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284001765 FeS/SAM binding site; other site 644284001766 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 644284001767 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 644284001768 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 644284001769 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 644284001770 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 644284001771 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 644284001772 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644284001773 active site 644284001774 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644284001775 protein binding site [polypeptide binding]; other site 644284001776 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 644284001777 putative substrate binding region [chemical binding]; other site 644284001778 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644284001779 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 644284001780 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644284001781 Predicted acetyltransferase [General function prediction only]; Region: COG3393 644284001782 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 644284001783 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644284001784 prolyl-tRNA synthetase; Provisional; Region: PRK09194 644284001785 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 644284001786 dimer interface [polypeptide binding]; other site 644284001787 motif 1; other site 644284001788 active site 644284001789 motif 2; other site 644284001790 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 644284001791 putative deacylase active site [active] 644284001792 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644284001793 active site 644284001794 motif 3; other site 644284001795 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 644284001796 anticodon binding site; other site 644284001797 ribosome maturation protein RimP; Reviewed; Region: PRK00092 644284001798 Sm and related proteins; Region: Sm_like; cl00259 644284001799 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 644284001800 putative oligomer interface [polypeptide binding]; other site 644284001801 putative RNA binding site [nucleotide binding]; other site 644284001802 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 644284001803 NusA N-terminal domain; Region: NusA_N; pfam08529 644284001804 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 644284001805 RNA binding site [nucleotide binding]; other site 644284001806 homodimer interface [polypeptide binding]; other site 644284001807 NusA-like KH domain; Region: KH_5; pfam13184 644284001808 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 644284001809 G-X-X-G motif; other site 644284001810 Protein of unknown function (DUF448); Region: DUF448; pfam04296 644284001811 putative RNA binding cleft [nucleotide binding]; other site 644284001812 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644284001813 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644284001814 translation initiation factor IF-2; Region: IF-2; TIGR00487 644284001815 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 644284001816 G1 box; other site 644284001817 putative GEF interaction site [polypeptide binding]; other site 644284001818 GTP/Mg2+ binding site [chemical binding]; other site 644284001819 Switch I region; other site 644284001820 G2 box; other site 644284001821 G3 box; other site 644284001822 Switch II region; other site 644284001823 G4 box; other site 644284001824 G5 box; other site 644284001825 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 644284001826 Translation-initiation factor 2; Region: IF-2; pfam11987 644284001827 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 644284001828 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 644284001829 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 644284001830 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 644284001831 RNA binding site [nucleotide binding]; other site 644284001832 active site 644284001833 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 644284001834 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 644284001835 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 644284001836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284001837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644284001838 Walker A/P-loop; other site 644284001839 ATP binding site [chemical binding]; other site 644284001840 Q-loop/lid; other site 644284001841 ABC transporter signature motif; other site 644284001842 Walker B; other site 644284001843 D-loop; other site 644284001844 H-loop/switch region; other site 644284001845 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644284001846 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644284001847 FtsX-like permease family; Region: FtsX; pfam02687 644284001848 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 644284001849 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 644284001850 active site 644284001851 Riboflavin kinase; Region: Flavokinase; pfam01687 644284001852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001853 Walker B; other site 644284001854 D-loop; other site 644284001855 Htaa; Region: HtaA; pfam04213 644284001856 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 644284001857 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 644284001858 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 644284001859 Substrate binding site [chemical binding]; other site 644284001860 Leucine rich repeat; Region: LRR_8; pfam13855 644284001861 Htaa; Region: HtaA; pfam04213 644284001862 Htaa; Region: HtaA; pfam04213 644284001863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284001864 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 644284001865 intersubunit interface [polypeptide binding]; other site 644284001866 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 644284001867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284001868 ABC-ATPase subunit interface; other site 644284001869 dimer interface [polypeptide binding]; other site 644284001870 putative PBP binding regions; other site 644284001871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644284001872 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 644284001873 Walker A/P-loop; other site 644284001874 ATP binding site [chemical binding]; other site 644284001875 Q-loop/lid; other site 644284001876 ABC transporter signature motif; other site 644284001877 Walker B; other site 644284001878 D-loop; other site 644284001879 H-loop/switch region; other site 644284001880 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 644284001881 16S/18S rRNA binding site [nucleotide binding]; other site 644284001882 S13e-L30e interaction site [polypeptide binding]; other site 644284001883 25S rRNA binding site [nucleotide binding]; other site 644284001884 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 644284001885 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 644284001886 oligomer interface [polypeptide binding]; other site 644284001887 RNA binding site [nucleotide binding]; other site 644284001888 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 644284001889 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 644284001890 RNase E interface [polypeptide binding]; other site 644284001891 trimer interface [polypeptide binding]; other site 644284001892 active site 644284001893 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 644284001894 putative nucleic acid binding region [nucleotide binding]; other site 644284001895 G-X-X-G motif; other site 644284001896 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 644284001897 RNA binding site [nucleotide binding]; other site 644284001898 domain interface; other site 644284001899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284001900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284001901 putative substrate translocation pore; other site 644284001902 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 644284001903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 644284001904 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 644284001905 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644284001906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284001907 Walker A/P-loop; other site 644284001908 ATP binding site [chemical binding]; other site 644284001909 Q-loop/lid; other site 644284001910 ABC transporter signature motif; other site 644284001911 Walker B; other site 644284001912 D-loop; other site 644284001913 H-loop/switch region; other site 644284001914 TOBE domain; Region: TOBE_2; pfam08402 644284001915 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 644284001916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001917 dimer interface [polypeptide binding]; other site 644284001918 conserved gate region; other site 644284001919 putative PBP binding loops; other site 644284001920 ABC-ATPase subunit interface; other site 644284001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284001922 dimer interface [polypeptide binding]; other site 644284001923 conserved gate region; other site 644284001924 putative PBP binding loops; other site 644284001925 ABC-ATPase subunit interface; other site 644284001926 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 644284001927 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 644284001928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284001929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284001930 active site 644284001931 phosphorylation site [posttranslational modification] 644284001932 intermolecular recognition site; other site 644284001933 dimerization interface [polypeptide binding]; other site 644284001934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284001935 DNA binding site [nucleotide binding] 644284001936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644284001937 dimer interface [polypeptide binding]; other site 644284001938 phosphorylation site [posttranslational modification] 644284001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284001940 ATP binding site [chemical binding]; other site 644284001941 Mg2+ binding site [ion binding]; other site 644284001942 G-X-G motif; other site 644284001943 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 644284001944 putative ligand binding site [chemical binding]; other site 644284001945 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 644284001946 putative NAD binding site [chemical binding]; other site 644284001947 catalytic site [active] 644284001948 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 644284001949 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 644284001950 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 644284001951 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 644284001952 Competence-damaged protein; Region: CinA; pfam02464 644284001953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284001954 non-specific DNA binding site [nucleotide binding]; other site 644284001955 salt bridge; other site 644284001956 sequence-specific DNA binding site [nucleotide binding]; other site 644284001957 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 644284001958 recombinase A; Provisional; Region: recA; PRK09354 644284001959 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 644284001960 hexamer interface [polypeptide binding]; other site 644284001961 Walker A motif; other site 644284001962 ATP binding site [chemical binding]; other site 644284001963 Walker B motif; other site 644284001964 recombination regulator RecX; Reviewed; Region: recX; PRK00117 644284001965 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 644284001966 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 644284001967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284001968 FeS/SAM binding site; other site 644284001969 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 644284001970 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 644284001971 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 644284001972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284001973 S-adenosylmethionine binding site [chemical binding]; other site 644284001974 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 644284001975 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 644284001976 HflX GTPase family; Region: HflX; cd01878 644284001977 G1 box; other site 644284001978 GTP/Mg2+ binding site [chemical binding]; other site 644284001979 Switch I region; other site 644284001980 G2 box; other site 644284001981 G3 box; other site 644284001982 Switch II region; other site 644284001983 G4 box; other site 644284001984 G5 box; other site 644284001985 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 644284001986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644284001987 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 644284001988 LexA repressor; Validated; Region: PRK00215 644284001989 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 644284001990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 644284001991 Catalytic site [active] 644284001992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644284001993 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 644284001994 ATP cone domain; Region: ATP-cone; pfam03477 644284001995 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 644284001996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644284001997 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644284001998 acyl-activating enzyme (AAE) consensus motif; other site 644284001999 AMP binding site [chemical binding]; other site 644284002000 active site 644284002001 CoA binding site [chemical binding]; other site 644284002002 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 644284002003 Part of AAA domain; Region: AAA_19; pfam13245 644284002004 Family description; Region: UvrD_C_2; pfam13538 644284002005 PAC2 family; Region: PAC2; pfam09754 644284002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284002007 S-adenosylmethionine binding site [chemical binding]; other site 644284002008 DNA polymerase IV; Validated; Region: PRK03858 644284002009 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 644284002010 active site 644284002011 DNA binding site [nucleotide binding] 644284002012 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 644284002013 cell division protein MraZ; Reviewed; Region: PRK00326 644284002014 MraZ protein; Region: MraZ; pfam02381 644284002015 MraZ protein; Region: MraZ; pfam02381 644284002016 MraW methylase family; Region: Methyltransf_5; cl17771 644284002017 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 644284002018 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 644284002019 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644284002020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 644284002021 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 644284002022 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644284002023 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284002024 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644284002025 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 644284002026 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644284002027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284002028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644284002029 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 644284002030 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 644284002031 Mg++ binding site [ion binding]; other site 644284002032 putative catalytic motif [active] 644284002033 putative substrate binding site [chemical binding]; other site 644284002034 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 644284002035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284002036 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 644284002037 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 644284002038 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 644284002039 active site 644284002040 homodimer interface [polypeptide binding]; other site 644284002041 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 644284002042 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644284002043 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284002044 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644284002045 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 644284002046 Cell division protein FtsQ; Region: FtsQ; pfam03799 644284002047 cell division protein FtsZ; Validated; Region: PRK09330 644284002048 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 644284002049 nucleotide binding site [chemical binding]; other site 644284002050 SulA interaction site; other site 644284002051 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 644284002052 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 644284002053 Protein of unknown function (DUF552); Region: DUF552; pfam04472 644284002054 cell division protein GpsB; Provisional; Region: PRK14127 644284002055 DivIVA domain; Region: DivI1A_domain; TIGR03544 644284002056 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 644284002057 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 644284002058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284002059 RNA binding surface [nucleotide binding]; other site 644284002060 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644284002061 active site 644284002062 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 644284002063 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 644284002064 active site 644284002065 PHP Thumb interface [polypeptide binding]; other site 644284002066 metal binding site [ion binding]; metal-binding site 644284002067 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 644284002068 generic binding surface II; other site 644284002069 generic binding surface I; other site 644284002070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284002071 RNA binding surface [nucleotide binding]; other site 644284002072 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644284002073 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 644284002074 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644284002075 metal binding site 2 [ion binding]; metal-binding site 644284002076 putative DNA binding helix; other site 644284002077 metal binding site 1 [ion binding]; metal-binding site 644284002078 dimer interface [polypeptide binding]; other site 644284002079 structural Zn2+ binding site [ion binding]; other site 644284002080 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284002081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284002082 putative PBP binding regions; other site 644284002083 ABC-ATPase subunit interface; other site 644284002084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284002085 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644284002086 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284002087 intersubunit interface [polypeptide binding]; other site 644284002088 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644284002089 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284002090 glycyl-tRNA synthetase; Provisional; Region: PRK04173 644284002091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644284002092 motif 1; other site 644284002093 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 644284002094 active site 644284002095 motif 2; other site 644284002096 motif 3; other site 644284002097 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 644284002098 anticodon binding site; other site 644284002099 YibE/F-like protein; Region: YibE_F; pfam07907 644284002100 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 644284002101 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 644284002102 FMN binding site [chemical binding]; other site 644284002103 active site 644284002104 catalytic residues [active] 644284002105 substrate binding site [chemical binding]; other site 644284002106 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 644284002107 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644284002108 Zn2+ binding site [ion binding]; other site 644284002109 Mg2+ binding site [ion binding]; other site 644284002110 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 644284002111 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 644284002112 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 644284002113 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 644284002114 Walker A/P-loop; other site 644284002115 ATP binding site [chemical binding]; other site 644284002116 Q-loop/lid; other site 644284002117 ABC transporter signature motif; other site 644284002118 Walker B; other site 644284002119 D-loop; other site 644284002120 H-loop/switch region; other site 644284002121 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644284002122 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644284002123 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 644284002124 TM-ABC transporter signature motif; other site 644284002125 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644284002126 active site residue [active] 644284002127 DNA primase; Validated; Region: dnaG; PRK05667 644284002128 CHC2 zinc finger; Region: zf-CHC2; pfam01807 644284002129 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644284002130 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644284002131 active site 644284002132 metal binding site [ion binding]; metal-binding site 644284002133 interdomain interaction site; other site 644284002134 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 644284002135 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 644284002136 Cutinase; Region: Cutinase; pfam01083 644284002137 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 644284002138 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 644284002139 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 644284002140 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 644284002141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644284002142 NAD(P) binding site [chemical binding]; other site 644284002143 active site 644284002144 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 644284002145 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 644284002146 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 644284002147 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644284002148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284002149 motif II; other site 644284002150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284002151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284002152 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 644284002153 Walker A/P-loop; other site 644284002154 ATP binding site [chemical binding]; other site 644284002155 Q-loop/lid; other site 644284002156 ABC transporter signature motif; other site 644284002157 Walker B; other site 644284002158 D-loop; other site 644284002159 H-loop/switch region; other site 644284002160 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284002161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284002162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284002163 Walker A/P-loop; other site 644284002164 ATP binding site [chemical binding]; other site 644284002165 Q-loop/lid; other site 644284002166 ABC transporter signature motif; other site 644284002167 Walker B; other site 644284002168 D-loop; other site 644284002169 H-loop/switch region; other site 644284002170 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 644284002171 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 644284002172 dimer interface [polypeptide binding]; other site 644284002173 TPP-binding site [chemical binding]; other site 644284002174 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 644284002175 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 644284002176 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 644284002177 active site 644284002178 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 644284002179 Uncharacterized conserved protein [Function unknown]; Region: COG0327 644284002180 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 644284002181 hypothetical protein; Validated; Region: PRK02101 644284002182 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284002183 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284002184 nucleotide binding site [chemical binding]; other site 644284002185 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 644284002186 active site 644284002187 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 644284002188 oligomerization interface [polypeptide binding]; other site 644284002189 active site 644284002190 metal binding site [ion binding]; metal-binding site 644284002191 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 644284002192 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644284002193 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644284002194 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 644284002195 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 644284002196 metal binding triad; other site 644284002197 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 644284002198 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 644284002199 metal binding triad; other site 644284002200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644284002201 catalytic core [active] 644284002202 glutamine synthetase, type I; Region: GlnA; TIGR00653 644284002203 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644284002204 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644284002205 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 644284002206 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644284002207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284002208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284002209 putative substrate translocation pore; other site 644284002210 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 644284002211 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644284002212 E3 interaction surface; other site 644284002213 lipoyl attachment site [posttranslational modification]; other site 644284002214 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644284002215 E3 interaction surface; other site 644284002216 lipoyl attachment site [posttranslational modification]; other site 644284002217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 644284002218 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 644284002219 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 644284002220 catalytic residue [active] 644284002221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644284002222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644284002223 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644284002224 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644284002225 Walker A/P-loop; other site 644284002226 ATP binding site [chemical binding]; other site 644284002227 Q-loop/lid; other site 644284002228 ABC transporter signature motif; other site 644284002229 Walker B; other site 644284002230 D-loop; other site 644284002231 H-loop/switch region; other site 644284002232 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644284002233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284002234 ABC-ATPase subunit interface; other site 644284002235 dimer interface [polypeptide binding]; other site 644284002236 putative PBP binding regions; other site 644284002237 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 644284002238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284002239 ABC-ATPase subunit interface; other site 644284002240 dimer interface [polypeptide binding]; other site 644284002241 putative PBP binding regions; other site 644284002242 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 644284002243 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284002244 intersubunit interface [polypeptide binding]; other site 644284002245 multifunctional aminopeptidase A; Provisional; Region: PRK00913 644284002246 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 644284002247 interface (dimer of trimers) [polypeptide binding]; other site 644284002248 Substrate-binding/catalytic site; other site 644284002249 Zn-binding sites [ion binding]; other site 644284002250 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 644284002251 hypothetical protein; Provisional; Region: PRK07907 644284002252 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 644284002253 active site 644284002254 metal binding site [ion binding]; metal-binding site 644284002255 dimer interface [polypeptide binding]; other site 644284002256 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 644284002257 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644284002258 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 644284002259 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 644284002260 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 644284002261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 644284002262 active site 644284002263 phosphorylation site [posttranslational modification] 644284002264 intermolecular recognition site; other site 644284002265 dimerization interface [polypeptide binding]; other site 644284002266 hypothetical protein; Validated; Region: PRK07883 644284002267 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644284002268 active site 644284002269 catalytic site [active] 644284002270 substrate binding site [chemical binding]; other site 644284002271 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 644284002272 GIY-YIG motif/motif A; other site 644284002273 active site 644284002274 catalytic site [active] 644284002275 putative DNA binding site [nucleotide binding]; other site 644284002276 metal binding site [ion binding]; metal-binding site 644284002277 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 644284002278 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 644284002279 active site 644284002280 ADP/pyrophosphate binding site [chemical binding]; other site 644284002281 allosteric effector site; other site 644284002282 fructose-1,6-bisphosphate binding site; other site 644284002283 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 644284002284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 644284002285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 644284002286 active site 644284002287 ATP binding site [chemical binding]; other site 644284002288 substrate binding site [chemical binding]; other site 644284002289 activation loop (A-loop); other site 644284002290 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644284002291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 644284002292 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284002293 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284002294 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284002295 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284002296 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644284002297 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644284002298 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644284002299 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 644284002300 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644284002301 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644284002302 catalytic residue [active] 644284002303 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644284002304 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644284002305 substrate binding pocket [chemical binding]; other site 644284002306 chain length determination region; other site 644284002307 substrate-Mg2+ binding site; other site 644284002308 catalytic residues [active] 644284002309 aspartate-rich region 1; other site 644284002310 active site lid residues [active] 644284002311 aspartate-rich region 2; other site 644284002312 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 644284002313 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 644284002314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644284002315 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644284002316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644284002317 DNA binding residues [nucleotide binding] 644284002318 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 644284002319 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644284002320 active site 644284002321 catalytic site [active] 644284002322 substrate binding site [chemical binding]; other site 644284002323 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 644284002324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284002325 Mg2+ binding site [ion binding]; other site 644284002326 G-X-G motif; other site 644284002327 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644284002328 anchoring element; other site 644284002329 dimer interface [polypeptide binding]; other site 644284002330 ATP binding site [chemical binding]; other site 644284002331 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644284002332 active site 644284002333 putative metal-binding site [ion binding]; other site 644284002334 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644284002335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644284002336 Coenzyme A binding pocket [chemical binding]; other site 644284002337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 644284002338 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 644284002339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284002340 Coenzyme A binding pocket [chemical binding]; other site 644284002341 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 644284002342 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 644284002343 CAP-like domain; other site 644284002344 active site 644284002345 primary dimer interface [polypeptide binding]; other site 644284002346 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284002347 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644284002348 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 644284002349 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 644284002350 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 644284002351 thymidine kinase; Provisional; Region: PRK04296 644284002352 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644284002353 ATP binding site [chemical binding]; other site 644284002354 Walker A motif; other site 644284002355 Walker B motif; other site 644284002356 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 644284002357 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 644284002358 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 644284002359 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 644284002360 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644284002361 TrkA-N domain; Region: TrkA_N; pfam02254 644284002362 TrkA-C domain; Region: TrkA_C; pfam02080 644284002363 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644284002364 TrkA-N domain; Region: TrkA_N; pfam02254 644284002365 TrkA-C domain; Region: TrkA_C; pfam02080 644284002366 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 644284002367 DNA methylase; Region: N6_N4_Mtase; pfam01555 644284002368 DNA methylase; Region: N6_N4_Mtase; cl17433 644284002369 Restriction endonuclease [Defense mechanisms]; Region: COG3587 644284002370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284002371 ATP binding site [chemical binding]; other site 644284002372 putative Mg++ binding site [ion binding]; other site 644284002373 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644284002374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284002375 ATP binding site [chemical binding]; other site 644284002376 putative Mg++ binding site [ion binding]; other site 644284002377 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 644284002378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284002379 nucleotide binding region [chemical binding]; other site 644284002380 ATP-binding site [chemical binding]; other site 644284002381 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 644284002382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284002383 Transposase; Region: HTH_Tnp_1; cl17663 644284002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 644284002385 HTH-like domain; Region: HTH_21; pfam13276 644284002386 Integrase core domain; Region: rve; pfam00665 644284002387 Integrase core domain; Region: rve_3; pfam13683 644284002388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284002389 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284002390 DNA-binding interface [nucleotide binding]; DNA binding site 644284002391 putative transposase OrfB; Reviewed; Region: PHA02517 644284002392 HTH-like domain; Region: HTH_21; pfam13276 644284002393 Integrase core domain; Region: rve; pfam00665 644284002394 Integrase core domain; Region: rve_3; pfam13683 644284002395 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644284002396 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644284002397 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 644284002398 Walker A/P-loop; other site 644284002399 ATP binding site [chemical binding]; other site 644284002400 Q-loop/lid; other site 644284002401 ABC transporter signature motif; other site 644284002402 Walker B; other site 644284002403 D-loop; other site 644284002404 H-loop/switch region; other site 644284002405 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644284002406 FtsX-like permease family; Region: FtsX; pfam02687 644284002407 AIR carboxylase; Region: AIRC; pfam00731 644284002408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284002409 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284002410 DNA-binding interface [nucleotide binding]; DNA binding site 644284002411 putative transposase OrfB; Reviewed; Region: PHA02517 644284002412 HTH-like domain; Region: HTH_21; pfam13276 644284002413 Integrase core domain; Region: rve; pfam00665 644284002414 Integrase core domain; Region: rve_3; pfam13683 644284002415 aconitate hydratase; Validated; Region: PRK09277 644284002416 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 644284002417 substrate binding site [chemical binding]; other site 644284002418 ligand binding site [chemical binding]; other site 644284002419 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 644284002420 substrate binding site [chemical binding]; other site 644284002421 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 644284002422 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 644284002423 TPP-binding site [chemical binding]; other site 644284002424 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644284002425 PYR/PP interface [polypeptide binding]; other site 644284002426 dimer interface [polypeptide binding]; other site 644284002427 TPP binding site [chemical binding]; other site 644284002428 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 644284002429 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 644284002430 catalytic site [active] 644284002431 putative active site [active] 644284002432 putative substrate binding site [chemical binding]; other site 644284002433 HRDC domain; Region: HRDC; pfam00570 644284002434 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 644284002435 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 644284002436 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 644284002437 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 644284002438 catalytic site [active] 644284002439 active site 644284002440 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 644284002441 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 644284002442 active site 644284002443 catalytic site [active] 644284002444 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 644284002445 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 644284002446 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 644284002447 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 644284002448 active site 644284002449 catalytic site [active] 644284002450 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644284002451 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 644284002452 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 644284002453 G1 box; other site 644284002454 GTP/Mg2+ binding site [chemical binding]; other site 644284002455 G2 box; other site 644284002456 Switch I region; other site 644284002457 G3 box; other site 644284002458 Switch II region; other site 644284002459 G4 box; other site 644284002460 G5 box; other site 644284002461 Nucleoside recognition; Region: Gate; pfam07670 644284002462 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 644284002463 YodA lipocalin-like domain; Region: YodA; cl01365 644284002464 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 644284002465 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284002466 intersubunit interface [polypeptide binding]; other site 644284002467 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284002468 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 644284002469 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284002470 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644284002471 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284002472 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284002473 ABC-ATPase subunit interface; other site 644284002474 dimer interface [polypeptide binding]; other site 644284002475 putative PBP binding regions; other site 644284002476 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 644284002477 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 644284002478 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 644284002479 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 644284002480 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 644284002481 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 644284002482 active site 644284002483 dimer interface [polypeptide binding]; other site 644284002484 motif 1; other site 644284002485 motif 2; other site 644284002486 motif 3; other site 644284002487 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 644284002488 anticodon binding site; other site 644284002489 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 644284002490 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 644284002491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 644284002492 putative acyl-acceptor binding pocket; other site 644284002493 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644284002494 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644284002495 Protease prsW family; Region: PrsW-protease; pfam13367 644284002496 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644284002497 nudix motif; other site 644284002498 hypothetical protein; Validated; Region: PRK00110 644284002499 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 644284002500 active site 644284002501 putative DNA-binding cleft [nucleotide binding]; other site 644284002502 dimer interface [polypeptide binding]; other site 644284002503 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 644284002504 RuvA N terminal domain; Region: RuvA_N; pfam01330 644284002505 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 644284002506 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 644284002507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284002508 Walker A motif; other site 644284002509 ATP binding site [chemical binding]; other site 644284002510 Walker B motif; other site 644284002511 arginine finger; other site 644284002512 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 644284002513 Preprotein translocase subunit; Region: YajC; pfam02699 644284002514 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 644284002515 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 644284002516 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 644284002517 Protein export membrane protein; Region: SecD_SecF; pfam02355 644284002518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644284002519 active site 644284002520 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 644284002521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644284002522 Zn2+ binding site [ion binding]; other site 644284002523 Mg2+ binding site [ion binding]; other site 644284002524 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644284002525 synthetase active site [active] 644284002526 NTP binding site [chemical binding]; other site 644284002527 metal binding site [ion binding]; metal-binding site 644284002528 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 644284002529 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 644284002530 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 644284002531 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 644284002532 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 644284002533 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 644284002534 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 644284002535 dimer interface [polypeptide binding]; other site 644284002536 motif 1; other site 644284002537 active site 644284002538 motif 2; other site 644284002539 motif 3; other site 644284002540 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 644284002541 anticodon binding site; other site 644284002542 Protein of unknown function, DUF258; Region: DUF258; pfam03193 644284002543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 644284002544 G1 box; other site 644284002545 GTP/Mg2+ binding site [chemical binding]; other site 644284002546 G2 box; other site 644284002547 Switch I region; other site 644284002548 G3 box; other site 644284002549 Switch II region; other site 644284002550 G4 box; other site 644284002551 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 644284002552 G1 box; other site 644284002553 GTP/Mg2+ binding site [chemical binding]; other site 644284002554 G2 box; other site 644284002555 Switch I region; other site 644284002556 G3 box; other site 644284002557 Switch II region; other site 644284002558 G4 box; other site 644284002559 helicase 45; Provisional; Region: PTZ00424 644284002560 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644284002561 ATP binding site [chemical binding]; other site 644284002562 Mg++ binding site [ion binding]; other site 644284002563 motif III; other site 644284002564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284002565 nucleotide binding region [chemical binding]; other site 644284002566 ATP-binding site [chemical binding]; other site 644284002567 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 644284002568 putative RNA binding site [nucleotide binding]; other site 644284002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284002570 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644284002571 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 644284002572 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 644284002573 dimer interface [polypeptide binding]; other site 644284002574 anticodon binding site; other site 644284002575 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 644284002576 homodimer interface [polypeptide binding]; other site 644284002577 motif 1; other site 644284002578 active site 644284002579 motif 2; other site 644284002580 GAD domain; Region: GAD; pfam02938 644284002581 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644284002582 active site 644284002583 motif 3; other site 644284002584 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 644284002585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 644284002586 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 644284002587 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 644284002588 recombination factor protein RarA; Reviewed; Region: PRK13342 644284002589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284002590 Walker A motif; other site 644284002591 ATP binding site [chemical binding]; other site 644284002592 Walker B motif; other site 644284002593 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644284002594 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 644284002595 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 644284002596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284002597 RNA binding surface [nucleotide binding]; other site 644284002598 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 644284002599 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 644284002600 motif 1; other site 644284002601 active site 644284002602 motif 2; other site 644284002603 motif 3; other site 644284002604 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 644284002605 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 644284002606 YceG-like family; Region: YceG; pfam02618 644284002607 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 644284002608 dimerization interface [polypeptide binding]; other site 644284002609 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 644284002610 NAD(P) binding pocket [chemical binding]; other site 644284002611 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 644284002612 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 644284002613 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 644284002614 Tetramer interface [polypeptide binding]; other site 644284002615 active site 644284002616 FMN-binding site [chemical binding]; other site 644284002617 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 644284002618 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 644284002619 ADP binding site [chemical binding]; other site 644284002620 magnesium binding site [ion binding]; other site 644284002621 putative shikimate binding site; other site 644284002622 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 644284002623 active site 644284002624 dimer interface [polypeptide binding]; other site 644284002625 metal binding site [ion binding]; metal-binding site 644284002626 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 644284002627 elongation factor P; Validated; Region: PRK00529 644284002628 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 644284002629 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 644284002630 RNA binding site [nucleotide binding]; other site 644284002631 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 644284002632 RNA binding site [nucleotide binding]; other site 644284002633 transcription antitermination factor NusB; Region: nusB; TIGR01951 644284002634 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 644284002635 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 644284002636 catalytic site [active] 644284002637 G-X2-G-X-G-K; other site 644284002638 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 644284002639 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 644284002640 Flavoprotein; Region: Flavoprotein; pfam02441 644284002641 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 644284002642 S-adenosylmethionine synthetase; Validated; Region: PRK05250 644284002643 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 644284002644 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 644284002645 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 644284002646 primosome assembly protein PriA; Provisional; Region: PRK14873 644284002647 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 644284002648 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 644284002649 putative active site [active] 644284002650 substrate binding site [chemical binding]; other site 644284002651 putative cosubstrate binding site; other site 644284002652 catalytic site [active] 644284002653 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 644284002654 substrate binding site [chemical binding]; other site 644284002655 NusB family; Region: NusB; pfam01029 644284002656 16S rRNA methyltransferase B; Provisional; Region: PRK14902 644284002657 putative RNA binding site [nucleotide binding]; other site 644284002658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284002659 S-adenosylmethionine binding site [chemical binding]; other site 644284002660 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 644284002661 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 644284002662 substrate binding site [chemical binding]; other site 644284002663 hexamer interface [polypeptide binding]; other site 644284002664 metal binding site [ion binding]; metal-binding site 644284002665 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 644284002666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284002667 dimer interface [polypeptide binding]; other site 644284002668 conserved gate region; other site 644284002669 putative PBP binding loops; other site 644284002670 ABC-ATPase subunit interface; other site 644284002671 NMT1/THI5 like; Region: NMT1; pfam09084 644284002672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644284002673 substrate binding pocket [chemical binding]; other site 644284002674 membrane-bound complex binding site; other site 644284002675 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 644284002676 Predicted transcriptional regulator [Transcription]; Region: COG2378 644284002677 WYL domain; Region: WYL; pfam13280 644284002678 WYL domain; Region: WYL; pfam13280 644284002679 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644284002680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284002681 ATP binding site [chemical binding]; other site 644284002682 putative Mg++ binding site [ion binding]; other site 644284002683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284002684 nucleotide binding region [chemical binding]; other site 644284002685 ATP-binding site [chemical binding]; other site 644284002686 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 644284002687 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 644284002688 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 644284002689 putative active site [active] 644284002690 catalytic triad [active] 644284002691 putative dimer interface [polypeptide binding]; other site 644284002692 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 644284002693 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 644284002694 DNA binding residues [nucleotide binding] 644284002695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644284002696 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 644284002697 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644284002698 DNA binding residues [nucleotide binding] 644284002699 dimer interface [polypeptide binding]; other site 644284002700 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 644284002701 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 644284002702 phosphopeptide binding site; other site 644284002703 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 644284002704 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 644284002705 Zn binding site [ion binding]; other site 644284002706 GTP-binding protein Der; Reviewed; Region: PRK03003 644284002707 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 644284002708 G1 box; other site 644284002709 GTP/Mg2+ binding site [chemical binding]; other site 644284002710 Switch I region; other site 644284002711 G2 box; other site 644284002712 Switch II region; other site 644284002713 G3 box; other site 644284002714 G4 box; other site 644284002715 G5 box; other site 644284002716 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 644284002717 G1 box; other site 644284002718 GTP/Mg2+ binding site [chemical binding]; other site 644284002719 Switch I region; other site 644284002720 G2 box; other site 644284002721 G3 box; other site 644284002722 Switch II region; other site 644284002723 G4 box; other site 644284002724 G5 box; other site 644284002725 cytidylate kinase; Provisional; Region: cmk; PRK00023 644284002726 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 644284002727 CMP-binding site; other site 644284002728 The sites determining sugar specificity; other site 644284002729 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 644284002730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284002731 RNA binding surface [nucleotide binding]; other site 644284002732 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 644284002733 active site 644284002734 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 644284002735 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 644284002736 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644284002737 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284002738 P-loop; other site 644284002739 Magnesium ion binding site [ion binding]; other site 644284002740 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284002741 Magnesium ion binding site [ion binding]; other site 644284002742 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 644284002743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644284002744 active site 644284002745 DNA binding site [nucleotide binding] 644284002746 Int/Topo IB signature motif; other site 644284002747 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 644284002748 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644284002749 TPP-binding site [chemical binding]; other site 644284002750 dimer interface [polypeptide binding]; other site 644284002751 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644284002752 PYR/PP interface [polypeptide binding]; other site 644284002753 dimer interface [polypeptide binding]; other site 644284002754 TPP binding site [chemical binding]; other site 644284002755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644284002756 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 644284002757 triosephosphate isomerase; Provisional; Region: PRK14567 644284002758 substrate binding site [chemical binding]; other site 644284002759 dimer interface [polypeptide binding]; other site 644284002760 catalytic triad [active] 644284002761 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 644284002762 Phosphoglycerate kinase; Region: PGK; pfam00162 644284002763 substrate binding site [chemical binding]; other site 644284002764 hinge regions; other site 644284002765 ADP binding site [chemical binding]; other site 644284002766 catalytic site [active] 644284002767 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 644284002768 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 644284002769 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 644284002770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 644284002771 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 644284002772 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 644284002773 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 644284002774 phosphate binding site [ion binding]; other site 644284002775 putative substrate binding pocket [chemical binding]; other site 644284002776 dimer interface [polypeptide binding]; other site 644284002777 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 644284002778 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 644284002779 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644284002780 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 644284002781 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 644284002782 YCII-related domain; Region: YCII; cl00999 644284002783 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 644284002784 excinuclease ABC subunit B; Provisional; Region: PRK05298 644284002785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284002786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284002787 nucleotide binding region [chemical binding]; other site 644284002788 ATP-binding site [chemical binding]; other site 644284002789 Ultra-violet resistance protein B; Region: UvrB; pfam12344 644284002790 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 644284002791 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 644284002792 CoA-binding site [chemical binding]; other site 644284002793 ATP-binding [chemical binding]; other site 644284002794 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 644284002795 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 644284002796 RNA binding site [nucleotide binding]; other site 644284002797 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 644284002798 RNA binding site [nucleotide binding]; other site 644284002799 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644284002800 RNA binding site [nucleotide binding]; other site 644284002801 S1 RNA binding domain; Region: S1; pfam00575 644284002802 RNA binding site [nucleotide binding]; other site 644284002803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284002804 S-adenosylmethionine binding site [chemical binding]; other site 644284002805 DNA polymerase I; Provisional; Region: PRK05755 644284002806 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 644284002807 active site 644284002808 metal binding site 1 [ion binding]; metal-binding site 644284002809 putative 5' ssDNA interaction site; other site 644284002810 metal binding site 3; metal-binding site 644284002811 metal binding site 2 [ion binding]; metal-binding site 644284002812 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 644284002813 putative DNA binding site [nucleotide binding]; other site 644284002814 putative metal binding site [ion binding]; other site 644284002815 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 644284002816 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 644284002817 active site 644284002818 DNA binding site [nucleotide binding] 644284002819 catalytic site [active] 644284002820 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 644284002821 CoenzymeA binding site [chemical binding]; other site 644284002822 subunit interaction site [polypeptide binding]; other site 644284002823 PHB binding site; other site 644284002824 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 644284002825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284002826 active site 644284002827 phosphorylation site [posttranslational modification] 644284002828 intermolecular recognition site; other site 644284002829 dimerization interface [polypeptide binding]; other site 644284002830 ANTAR domain; Region: ANTAR; pfam03861 644284002831 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 644284002832 pyruvate kinase; Provisional; Region: PRK06247 644284002833 domain interfaces; other site 644284002834 active site 644284002835 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 644284002836 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644284002837 Pup-ligase protein; Region: Pup_ligase; cl15463 644284002838 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 644284002839 Pup-ligase protein; Region: Pup_ligase; pfam03136 644284002840 proteasome ATPase; Region: pup_AAA; TIGR03689 644284002841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284002842 Walker A motif; other site 644284002843 ATP binding site [chemical binding]; other site 644284002844 Walker B motif; other site 644284002845 arginine finger; other site 644284002846 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 644284002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644284002848 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 644284002849 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 644284002850 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644284002851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284002852 motif II; other site 644284002853 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 644284002854 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644284002855 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644284002856 active site 644284002857 catalytic tetrad [active] 644284002858 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 644284002859 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 644284002860 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644284002861 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644284002862 shikimate binding site; other site 644284002863 NAD(P) binding site [chemical binding]; other site 644284002864 hypothetical protein; Provisional; Region: PRK06771 644284002865 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 644284002866 metal binding site [ion binding]; metal-binding site 644284002867 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 644284002868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644284002869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284002870 non-specific DNA binding site [nucleotide binding]; other site 644284002871 salt bridge; other site 644284002872 sequence-specific DNA binding site [nucleotide binding]; other site 644284002873 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644284002874 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 644284002875 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644284002876 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 644284002877 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 644284002878 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 644284002879 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644284002880 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644284002881 Walker A/P-loop; other site 644284002882 ATP binding site [chemical binding]; other site 644284002883 Q-loop/lid; other site 644284002884 ABC transporter signature motif; other site 644284002885 Walker B; other site 644284002886 D-loop; other site 644284002887 H-loop/switch region; other site 644284002888 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 644284002889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644284002890 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 644284002891 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 644284002892 ligand binding site; other site 644284002893 oligomer interface; other site 644284002894 Protein of unknown function (DUF3405); Region: DUF3405; pfam11885 644284002895 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 644284002896 dimer interface [polypeptide binding]; other site 644284002897 N-terminal domain interface [polypeptide binding]; other site 644284002898 sulfate 1 binding site; other site 644284002899 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644284002900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284002901 Walker A/P-loop; other site 644284002902 ATP binding site [chemical binding]; other site 644284002903 Q-loop/lid; other site 644284002904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284002905 ABC transporter signature motif; other site 644284002906 Walker B; other site 644284002907 D-loop; other site 644284002908 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284002909 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 644284002910 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 644284002911 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 644284002912 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 644284002913 trimerization site [polypeptide binding]; other site 644284002914 active site 644284002915 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644284002916 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 644284002917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644284002918 catalytic residue [active] 644284002919 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 644284002920 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 644284002921 Walker A/P-loop; other site 644284002922 ATP binding site [chemical binding]; other site 644284002923 Q-loop/lid; other site 644284002924 ABC transporter signature motif; other site 644284002925 Walker B; other site 644284002926 D-loop; other site 644284002927 H-loop/switch region; other site 644284002928 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 644284002929 [2Fe-2S] cluster binding site [ion binding]; other site 644284002930 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 644284002931 FeS assembly protein SufD; Region: sufD; TIGR01981 644284002932 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 644284002933 FeS assembly protein SufB; Region: sufB; TIGR01980 644284002934 Predicted transcriptional regulator [Transcription]; Region: COG2345 644284002935 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284002936 putative Zn2+ binding site [ion binding]; other site 644284002937 putative DNA binding site [nucleotide binding]; other site 644284002938 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644284002939 dimer interface [polypeptide binding]; other site 644284002940 ADP-ribose binding site [chemical binding]; other site 644284002941 active site 644284002942 nudix motif; other site 644284002943 metal binding site [ion binding]; metal-binding site 644284002944 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 644284002945 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 644284002946 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 644284002947 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 644284002948 Thiamine pyrophosphokinase; Region: TPK; cl08415 644284002949 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 644284002950 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 644284002951 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644284002952 Walker A/P-loop; other site 644284002953 ATP binding site [chemical binding]; other site 644284002954 Q-loop/lid; other site 644284002955 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 644284002956 ABC transporter signature motif; other site 644284002957 Walker B; other site 644284002958 D-loop; other site 644284002959 H-loop/switch region; other site 644284002960 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 644284002961 ATP-NAD kinase; Region: NAD_kinase; pfam01513 644284002962 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 644284002963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644284002964 RNA binding surface [nucleotide binding]; other site 644284002965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284002966 S-adenosylmethionine binding site [chemical binding]; other site 644284002967 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 644284002968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284002969 active site 644284002970 motif I; other site 644284002971 motif II; other site 644284002972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284002973 motif II; other site 644284002974 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 644284002975 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 644284002976 active site 644284002977 HIGH motif; other site 644284002978 dimer interface [polypeptide binding]; other site 644284002979 KMSKS motif; other site 644284002980 Uncharacterized membrane protein [Function unknown]; Region: COG3949 644284002981 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 644284002982 dimer interface [polypeptide binding]; other site 644284002983 FMN binding site [chemical binding]; other site 644284002984 NADPH bind site [chemical binding]; other site 644284002985 arginine repressor; Provisional; Region: PRK03341 644284002986 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 644284002987 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 644284002988 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 644284002989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644284002990 inhibitor-cofactor binding pocket; inhibition site 644284002991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644284002992 catalytic residue [active] 644284002993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 644284002994 classical (c) SDRs; Region: SDR_c; cd05233 644284002995 NAD(P) binding site [chemical binding]; other site 644284002996 active site 644284002997 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 644284002998 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 644284002999 putative tRNA-binding site [nucleotide binding]; other site 644284003000 B3/4 domain; Region: B3_4; pfam03483 644284003001 tRNA synthetase B5 domain; Region: B5; smart00874 644284003002 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 644284003003 dimer interface [polypeptide binding]; other site 644284003004 motif 1; other site 644284003005 motif 3; other site 644284003006 motif 2; other site 644284003007 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 644284003008 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 644284003009 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 644284003010 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 644284003011 dimer interface [polypeptide binding]; other site 644284003012 motif 1; other site 644284003013 active site 644284003014 motif 2; other site 644284003015 motif 3; other site 644284003016 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 644284003017 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 644284003018 inhibitor site; inhibition site 644284003019 active site 644284003020 dimer interface [polypeptide binding]; other site 644284003021 catalytic residue [active] 644284003022 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 644284003023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284003024 Walker A/P-loop; other site 644284003025 ATP binding site [chemical binding]; other site 644284003026 Q-loop/lid; other site 644284003027 ABC transporter signature motif; other site 644284003028 Walker B; other site 644284003029 D-loop; other site 644284003030 H-loop/switch region; other site 644284003031 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644284003032 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644284003033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284003034 dimer interface [polypeptide binding]; other site 644284003035 conserved gate region; other site 644284003036 putative PBP binding loops; other site 644284003037 ABC-ATPase subunit interface; other site 644284003038 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644284003039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284003040 Walker A/P-loop; other site 644284003041 ATP binding site [chemical binding]; other site 644284003042 Q-loop/lid; other site 644284003043 ABC transporter signature motif; other site 644284003044 Walker B; other site 644284003045 D-loop; other site 644284003046 H-loop/switch region; other site 644284003047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 644284003048 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644284003049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284003050 dimer interface [polypeptide binding]; other site 644284003051 conserved gate region; other site 644284003052 putative PBP binding loops; other site 644284003053 ABC-ATPase subunit interface; other site 644284003054 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 644284003055 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644284003056 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644284003057 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 644284003058 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644284003059 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 644284003060 23S rRNA binding site [nucleotide binding]; other site 644284003061 L21 binding site [polypeptide binding]; other site 644284003062 L13 binding site [polypeptide binding]; other site 644284003063 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 644284003064 translation initiation factor IF-3; Region: infC; TIGR00168 644284003065 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 644284003066 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 644284003067 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 644284003068 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 644284003069 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 644284003070 catalytic residue [active] 644284003071 putative FPP diphosphate binding site; other site 644284003072 putative FPP binding hydrophobic cleft; other site 644284003073 dimer interface [polypeptide binding]; other site 644284003074 putative IPP diphosphate binding site; other site 644284003075 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 644284003076 Recombination protein O N terminal; Region: RecO_N; pfam11967 644284003077 Recombination protein O C terminal; Region: RecO_C; pfam02565 644284003078 GTPase Era; Reviewed; Region: era; PRK00089 644284003079 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 644284003080 G1 box; other site 644284003081 GTP/Mg2+ binding site [chemical binding]; other site 644284003082 Switch I region; other site 644284003083 G2 box; other site 644284003084 Switch II region; other site 644284003085 G3 box; other site 644284003086 G4 box; other site 644284003087 G5 box; other site 644284003088 KH domain; Region: KH_2; pfam07650 644284003089 FOG: CBS domain [General function prediction only]; Region: COG0517 644284003090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 644284003091 Transporter associated domain; Region: CorC_HlyC; smart01091 644284003092 metal-binding heat shock protein; Provisional; Region: PRK00016 644284003093 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 644284003094 PhoH-like protein; Region: PhoH; pfam02562 644284003095 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 644284003096 RNA methyltransferase, RsmE family; Region: TIGR00046 644284003097 chaperone protein DnaJ; Provisional; Region: PRK14278 644284003098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644284003099 HSP70 interaction site [polypeptide binding]; other site 644284003100 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644284003101 Zn binding sites [ion binding]; other site 644284003102 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 644284003103 dimer interface [polypeptide binding]; other site 644284003104 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 644284003105 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 644284003106 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 644284003107 oligomeric interface; other site 644284003108 putative active site [active] 644284003109 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 644284003110 coproporphyrinogen III oxidase; Validated; Region: PRK05628 644284003111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284003112 FeS/SAM binding site; other site 644284003113 HemN C-terminal domain; Region: HemN_C; pfam06969 644284003114 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 644284003115 GTP-binding protein LepA; Provisional; Region: PRK05433 644284003116 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 644284003117 G1 box; other site 644284003118 putative GEF interaction site [polypeptide binding]; other site 644284003119 GTP/Mg2+ binding site [chemical binding]; other site 644284003120 Switch I region; other site 644284003121 G2 box; other site 644284003122 G3 box; other site 644284003123 Switch II region; other site 644284003124 G4 box; other site 644284003125 G5 box; other site 644284003126 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 644284003127 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 644284003128 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 644284003129 Bacterial PH domain; Region: DUF304; pfam03703 644284003130 PemK-like protein; Region: PemK; pfam02452 644284003131 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 644284003132 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 644284003133 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 644284003134 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 644284003135 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 644284003136 ligand binding site [chemical binding]; other site 644284003137 homodimer interface [polypeptide binding]; other site 644284003138 NAD(P) binding site [chemical binding]; other site 644284003139 trimer interface B [polypeptide binding]; other site 644284003140 trimer interface A [polypeptide binding]; other site 644284003141 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 644284003142 hypothetical protein; Reviewed; Region: PRK07914 644284003143 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 644284003144 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 644284003145 Competence protein; Region: Competence; pfam03772 644284003146 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 644284003147 SLBB domain; Region: SLBB; pfam10531 644284003148 Helix-hairpin-helix motif; Region: HHH; pfam00633 644284003149 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 644284003150 Domain of unknown function DUF87; Region: DUF87; pfam01935 644284003151 AAA-like domain; Region: AAA_10; pfam12846 644284003152 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 644284003153 active site 644284003154 catalytic residues [active] 644284003155 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 644284003156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284003157 active site 644284003158 HIGH motif; other site 644284003159 nucleotide binding site [chemical binding]; other site 644284003160 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284003161 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644284003162 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284003163 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644284003164 active site 644284003165 KMSKS motif; other site 644284003166 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 644284003167 tRNA binding surface [nucleotide binding]; other site 644284003168 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 644284003169 nucleotide binding site/active site [active] 644284003170 HIT family signature motif; other site 644284003171 catalytic residue [active] 644284003172 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 644284003173 putative active site [active] 644284003174 redox center [active] 644284003175 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644284003176 Eukaryotic phosphomannomutase; Region: PMM; cl17107 644284003177 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644284003178 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 644284003179 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 644284003180 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 644284003181 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 644284003182 Walker A/P-loop; other site 644284003183 ATP binding site [chemical binding]; other site 644284003184 Q-loop/lid; other site 644284003185 ABC transporter signature motif; other site 644284003186 Walker B; other site 644284003187 D-loop; other site 644284003188 H-loop/switch region; other site 644284003189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284003190 dimer interface [polypeptide binding]; other site 644284003191 conserved gate region; other site 644284003192 putative PBP binding loops; other site 644284003193 ABC-ATPase subunit interface; other site 644284003194 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 644284003195 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 644284003196 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 644284003197 Na binding site [ion binding]; other site 644284003198 DctM-like transporters; Region: DctM; pfam06808 644284003199 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 644284003200 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 644284003201 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 644284003202 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 644284003203 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 644284003204 putative substrate binding pocket [chemical binding]; other site 644284003205 AC domain interface; other site 644284003206 catalytic triad [active] 644284003207 AB domain interface; other site 644284003208 interchain disulfide; other site 644284003209 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 644284003210 putative active site [active] 644284003211 catalytic triad [active] 644284003212 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 644284003213 PA/protease or protease-like domain interface [polypeptide binding]; other site 644284003214 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 644284003215 catalytic residues [active] 644284003216 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 644284003217 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 644284003218 Protein of unknown function (DUF998); Region: DUF998; pfam06197 644284003219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644284003220 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 644284003221 nucleophilic elbow; other site 644284003222 catalytic triad; other site 644284003223 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 644284003224 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 644284003225 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 644284003226 dimer interface [polypeptide binding]; other site 644284003227 putative anticodon binding site; other site 644284003228 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 644284003229 motif 1; other site 644284003230 dimer interface [polypeptide binding]; other site 644284003231 active site 644284003232 motif 2; other site 644284003233 motif 3; other site 644284003234 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 644284003235 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644284003236 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 644284003237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644284003238 active site 644284003239 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 644284003240 active site 644284003241 dimer interface [polypeptide binding]; other site 644284003242 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 644284003243 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 644284003244 heterodimer interface [polypeptide binding]; other site 644284003245 active site 644284003246 FMN binding site [chemical binding]; other site 644284003247 homodimer interface [polypeptide binding]; other site 644284003248 substrate binding site [chemical binding]; other site 644284003249 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 644284003250 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 644284003251 FAD binding pocket [chemical binding]; other site 644284003252 FAD binding motif [chemical binding]; other site 644284003253 phosphate binding motif [ion binding]; other site 644284003254 beta-alpha-beta structure motif; other site 644284003255 NAD binding pocket [chemical binding]; other site 644284003256 Iron coordination center [ion binding]; other site 644284003257 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 644284003258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644284003259 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644284003260 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644284003261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644284003262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 644284003263 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 644284003264 IMP binding site; other site 644284003265 dimer interface [polypeptide binding]; other site 644284003266 interdomain contacts; other site 644284003267 partial ornithine binding site; other site 644284003268 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 644284003269 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 644284003270 active site 644284003271 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 644284003272 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 644284003273 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 644284003274 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 644284003275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644284003276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284003277 putative substrate translocation pore; other site 644284003278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284003279 CrcB-like protein; Region: CRCB; pfam02537 644284003280 CrcB-like protein; Region: CRCB; cl09114 644284003281 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644284003282 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644284003283 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 644284003284 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 644284003285 Sulfate transporter family; Region: Sulfate_transp; pfam00916 644284003286 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 644284003287 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 644284003288 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644284003289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644284003290 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644284003291 Abi-like protein; Region: Abi_2; cl01988 644284003292 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 644284003293 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 644284003294 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 644284003295 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 644284003296 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 644284003297 HsdM N-terminal domain; Region: HsdM_N; pfam12161 644284003298 Methyltransferase domain; Region: Methyltransf_26; pfam13659 644284003299 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 644284003300 DEAD-like helicases superfamily; Region: DEXDc; smart00487 644284003301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284003302 ATP binding site [chemical binding]; other site 644284003303 putative Mg++ binding site [ion binding]; other site 644284003304 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 644284003305 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 644284003306 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 644284003307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284003308 S-adenosylmethionine binding site [chemical binding]; other site 644284003309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 644284003310 Cupin domain; Region: Cupin_2; cl17218 644284003311 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 644284003312 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 644284003313 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644284003314 catalytic core [active] 644284003315 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 644284003316 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 644284003317 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 644284003318 active site 644284003319 (T/H)XGH motif; other site 644284003320 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644284003321 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644284003322 catalytic residues [active] 644284003323 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 644284003324 GTPase CgtA; Reviewed; Region: obgE; PRK12296 644284003325 GTP1/OBG; Region: GTP1_OBG; pfam01018 644284003326 Obg GTPase; Region: Obg; cd01898 644284003327 G1 box; other site 644284003328 GTP/Mg2+ binding site [chemical binding]; other site 644284003329 Switch I region; other site 644284003330 G2 box; other site 644284003331 G3 box; other site 644284003332 Switch II region; other site 644284003333 G4 box; other site 644284003334 G5 box; other site 644284003335 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 644284003336 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 644284003337 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 644284003338 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 644284003339 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 644284003340 homodimer interface [polypeptide binding]; other site 644284003341 oligonucleotide binding site [chemical binding]; other site 644284003342 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 644284003343 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 644284003344 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 644284003345 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 644284003346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284003347 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 644284003348 Walker A/P-loop; other site 644284003349 ATP binding site [chemical binding]; other site 644284003350 Q-loop/lid; other site 644284003351 ABC transporter signature motif; other site 644284003352 Walker B; other site 644284003353 D-loop; other site 644284003354 H-loop/switch region; other site 644284003355 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 644284003356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284003357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003358 Walker A/P-loop; other site 644284003359 ATP binding site [chemical binding]; other site 644284003360 Q-loop/lid; other site 644284003361 ABC transporter signature motif; other site 644284003362 Walker B; other site 644284003363 D-loop; other site 644284003364 H-loop/switch region; other site 644284003365 GAF domain; Region: GAF; pfam01590 644284003366 Histidine kinase; Region: HisKA_3; pfam07730 644284003367 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 644284003368 ATP binding site [chemical binding]; other site 644284003369 Mg2+ binding site [ion binding]; other site 644284003370 G-X-G motif; other site 644284003371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284003372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284003373 active site 644284003374 phosphorylation site [posttranslational modification] 644284003375 intermolecular recognition site; other site 644284003376 dimerization interface [polypeptide binding]; other site 644284003377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284003378 DNA binding residues [nucleotide binding] 644284003379 dimerization interface [polypeptide binding]; other site 644284003380 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 644284003381 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 644284003382 DNA binding site [nucleotide binding] 644284003383 catalytic residue [active] 644284003384 H2TH interface [polypeptide binding]; other site 644284003385 putative catalytic residues [active] 644284003386 turnover-facilitating residue; other site 644284003387 intercalation triad [nucleotide binding]; other site 644284003388 8OG recognition residue [nucleotide binding]; other site 644284003389 putative reading head residues; other site 644284003390 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 644284003391 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644284003392 ribonuclease III; Reviewed; Region: rnc; PRK00102 644284003393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 644284003394 dimerization interface [polypeptide binding]; other site 644284003395 active site 644284003396 metal binding site [ion binding]; metal-binding site 644284003397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 644284003398 dsRNA binding site [nucleotide binding]; other site 644284003399 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 644284003400 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 644284003401 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 644284003402 active site 644284003403 (T/H)XGH motif; other site 644284003404 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 644284003405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284003406 S-adenosylmethionine binding site [chemical binding]; other site 644284003407 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 644284003408 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 644284003409 generic binding surface II; other site 644284003410 ssDNA binding site; other site 644284003411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284003412 ATP binding site [chemical binding]; other site 644284003413 putative Mg++ binding site [ion binding]; other site 644284003414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284003415 nucleotide binding region [chemical binding]; other site 644284003416 ATP-binding site [chemical binding]; other site 644284003417 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 644284003418 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 644284003419 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644284003420 Walker A/P-loop; other site 644284003421 ATP binding site [chemical binding]; other site 644284003422 Q-loop/lid; other site 644284003423 ABC transporter signature motif; other site 644284003424 Walker B; other site 644284003425 D-loop; other site 644284003426 H-loop/switch region; other site 644284003427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284003428 ABC-ATPase subunit interface; other site 644284003429 dimer interface [polypeptide binding]; other site 644284003430 putative PBP binding regions; other site 644284003431 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284003432 ABC-ATPase subunit interface; other site 644284003433 dimer interface [polypeptide binding]; other site 644284003434 putative PBP binding regions; other site 644284003435 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 644284003436 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644284003437 intersubunit interface [polypeptide binding]; other site 644284003438 thiamine monophosphate kinase; Provisional; Region: PRK05731 644284003439 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 644284003440 ATP binding site [chemical binding]; other site 644284003441 dimerization interface [polypeptide binding]; other site 644284003442 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 644284003443 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 644284003444 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 644284003445 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 644284003446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644284003447 putative acyl-acceptor binding pocket; other site 644284003448 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 644284003449 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 644284003450 hinge; other site 644284003451 active site 644284003452 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 644284003453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 644284003454 Bacterial transcriptional regulator; Region: IclR; pfam01614 644284003455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644284003456 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644284003457 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 644284003458 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 644284003459 active site 644284003460 Zn binding site [ion binding]; other site 644284003461 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 644284003462 active site 644284003463 catalytic site [active] 644284003464 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 644284003465 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644284003466 HIGH motif; other site 644284003467 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644284003468 active site 644284003469 KMSKS motif; other site 644284003470 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 644284003471 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 644284003472 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 644284003473 Domain of unknown function DUF77; Region: DUF77; pfam01910 644284003474 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 644284003475 domain interaction interfaces [polypeptide binding]; other site 644284003476 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 644284003477 domain interaction interfaces [polypeptide binding]; other site 644284003478 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 644284003479 domain interaction interfaces [polypeptide binding]; other site 644284003480 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 644284003481 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 644284003482 catalytic triad [active] 644284003483 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644284003484 nudix motif; other site 644284003485 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 644284003486 active site 644284003487 dimerization interface [polypeptide binding]; other site 644284003488 ribonuclease PH; Reviewed; Region: rph; PRK00173 644284003489 Ribonuclease PH; Region: RNase_PH_bact; cd11362 644284003490 hexamer interface [polypeptide binding]; other site 644284003491 active site 644284003492 Fic family protein [Function unknown]; Region: COG3177 644284003493 Fic/DOC family; Region: Fic; pfam02661 644284003494 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 644284003495 glutamate racemase; Provisional; Region: PRK00865 644284003496 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 644284003497 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 644284003498 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 644284003499 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 644284003500 active site 644284003501 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 644284003502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284003503 ATP binding site [chemical binding]; other site 644284003504 putative Mg++ binding site [ion binding]; other site 644284003505 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 644284003506 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 644284003507 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644284003508 IHF dimer interface [polypeptide binding]; other site 644284003509 IHF - DNA interface [nucleotide binding]; other site 644284003510 Predicted permease [General function prediction only]; Region: COG2985 644284003511 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 644284003512 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 644284003513 Putative esterase; Region: Esterase; pfam00756 644284003514 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 644284003515 active pocket/dimerization site; other site 644284003516 active site 644284003517 phosphorylation site [posttranslational modification] 644284003518 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644284003519 dimerization domain swap beta strand [polypeptide binding]; other site 644284003520 regulatory protein interface [polypeptide binding]; other site 644284003521 active site 644284003522 regulatory phosphorylation site [posttranslational modification]; other site 644284003523 dihydroxyacetone kinase; Provisional; Region: PRK14479 644284003524 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 644284003525 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 644284003526 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644284003527 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 644284003528 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 644284003529 homodimer interface [polypeptide binding]; other site 644284003530 NAD binding pocket [chemical binding]; other site 644284003531 ATP binding pocket [chemical binding]; other site 644284003532 Mg binding site [ion binding]; other site 644284003533 active-site loop [active] 644284003534 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284003535 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 644284003536 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284003537 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 644284003538 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284003539 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 644284003540 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 644284003541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003542 Walker A/P-loop; other site 644284003543 ATP binding site [chemical binding]; other site 644284003544 Q-loop/lid; other site 644284003545 ABC transporter signature motif; other site 644284003546 Walker B; other site 644284003547 D-loop; other site 644284003548 H-loop/switch region; other site 644284003549 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 644284003550 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 644284003551 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 644284003552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284003553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284003554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284003555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284003556 active site 644284003557 phosphorylation site [posttranslational modification] 644284003558 intermolecular recognition site; other site 644284003559 dimerization interface [polypeptide binding]; other site 644284003560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284003561 DNA binding site [nucleotide binding] 644284003562 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 644284003563 dimer interface [polypeptide binding]; other site 644284003564 phosphorylation site [posttranslational modification] 644284003565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284003566 ATP binding site [chemical binding]; other site 644284003567 Mg2+ binding site [ion binding]; other site 644284003568 G-X-G motif; other site 644284003569 Ferrochelatase; Region: Ferrochelatase; pfam00762 644284003570 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 644284003571 C-terminal domain interface [polypeptide binding]; other site 644284003572 active site 644284003573 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 644284003574 active site 644284003575 N-terminal domain interface [polypeptide binding]; other site 644284003576 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 644284003577 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 644284003578 FMN binding site [chemical binding]; other site 644284003579 dimer interface [polypeptide binding]; other site 644284003580 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 644284003581 dimer interface [polypeptide binding]; other site 644284003582 catalytic triad [active] 644284003583 Flavodoxin domain; Region: Flavodoxin_5; cl17428 644284003584 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 644284003585 conserved cys residue [active] 644284003586 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 644284003587 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 644284003588 active site 644284003589 multimer interface [polypeptide binding]; other site 644284003590 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 644284003591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 644284003592 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 644284003593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644284003594 ABC-ATPase subunit interface; other site 644284003595 dimer interface [polypeptide binding]; other site 644284003596 putative PBP binding regions; other site 644284003597 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644284003598 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 644284003599 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 644284003600 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 644284003601 metal binding site [ion binding]; metal-binding site 644284003602 LssY C-terminus; Region: LssY_C; pfam14067 644284003603 Predicted transcriptional regulators [Transcription]; Region: COG1725 644284003604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284003605 DNA-binding site [nucleotide binding]; DNA binding site 644284003606 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284003607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644284003608 Walker A/P-loop; other site 644284003609 ATP binding site [chemical binding]; other site 644284003610 Q-loop/lid; other site 644284003611 ABC transporter signature motif; other site 644284003612 Walker B; other site 644284003613 D-loop; other site 644284003614 H-loop/switch region; other site 644284003615 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644284003616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003617 Walker A/P-loop; other site 644284003618 ATP binding site [chemical binding]; other site 644284003619 Q-loop/lid; other site 644284003620 ABC transporter signature motif; other site 644284003621 Walker B; other site 644284003622 D-loop; other site 644284003623 H-loop/switch region; other site 644284003624 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 644284003625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284003626 dimer interface [polypeptide binding]; other site 644284003627 conserved gate region; other site 644284003628 putative PBP binding loops; other site 644284003629 ABC-ATPase subunit interface; other site 644284003630 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644284003631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644284003632 substrate binding pocket [chemical binding]; other site 644284003633 membrane-bound complex binding site; other site 644284003634 hinge residues; other site 644284003635 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 644284003636 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 644284003637 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 644284003638 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 644284003639 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 644284003640 MgtC family; Region: MgtC; pfam02308 644284003641 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 644284003642 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 644284003643 FMN-binding domain; Region: FMN_bind; cl01081 644284003644 ApbE family; Region: ApbE; pfam02424 644284003645 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 644284003646 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 644284003647 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644284003648 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644284003649 UDP-glucose 4-epimerase; Region: PLN02240 644284003650 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 644284003651 NAD binding site [chemical binding]; other site 644284003652 homodimer interface [polypeptide binding]; other site 644284003653 active site 644284003654 substrate binding site [chemical binding]; other site 644284003655 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 644284003656 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 644284003657 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 644284003658 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644284003659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644284003660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284003661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284003662 argininosuccinate synthase; Provisional; Region: PRK13820 644284003663 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 644284003664 ANP binding site [chemical binding]; other site 644284003665 Substrate Binding Site II [chemical binding]; other site 644284003666 Substrate Binding Site I [chemical binding]; other site 644284003667 argininosuccinate lyase; Provisional; Region: PRK00855 644284003668 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 644284003669 active sites [active] 644284003670 tetramer interface [polypeptide binding]; other site 644284003671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644284003672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284003673 Coenzyme A binding pocket [chemical binding]; other site 644284003674 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 644284003675 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 644284003676 tetramer interface [polypeptide binding]; other site 644284003677 active site 644284003678 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 644284003679 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 644284003680 GDP-binding site [chemical binding]; other site 644284003681 ACT binding site; other site 644284003682 IMP binding site; other site 644284003683 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 644284003684 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 644284003685 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 644284003686 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644284003687 active site 644284003688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284003689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003691 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 644284003692 Walker A/P-loop; other site 644284003693 ATP binding site [chemical binding]; other site 644284003694 Q-loop/lid; other site 644284003695 ABC transporter signature motif; other site 644284003696 Walker B; other site 644284003697 D-loop; other site 644284003698 H-loop/switch region; other site 644284003699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284003700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284003701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003702 Walker A/P-loop; other site 644284003703 ATP binding site [chemical binding]; other site 644284003704 Q-loop/lid; other site 644284003705 ABC transporter signature motif; other site 644284003706 Walker B; other site 644284003707 D-loop; other site 644284003708 H-loop/switch region; other site 644284003709 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284003710 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644284003711 Walker A/P-loop; other site 644284003712 ATP binding site [chemical binding]; other site 644284003713 Q-loop/lid; other site 644284003714 ABC transporter signature motif; other site 644284003715 Walker B; other site 644284003716 D-loop; other site 644284003717 H-loop/switch region; other site 644284003718 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 644284003719 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 644284003720 Walker A/P-loop; other site 644284003721 ATP binding site [chemical binding]; other site 644284003722 Q-loop/lid; other site 644284003723 ABC transporter signature motif; other site 644284003724 Walker B; other site 644284003725 D-loop; other site 644284003726 H-loop/switch region; other site 644284003727 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 644284003728 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 644284003729 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 644284003730 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 644284003731 DNA binding residues [nucleotide binding] 644284003732 dimer interface [polypeptide binding]; other site 644284003733 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 644284003734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 644284003735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284003736 non-specific DNA binding site [nucleotide binding]; other site 644284003737 salt bridge; other site 644284003738 sequence-specific DNA binding site [nucleotide binding]; other site 644284003739 Peptidase family C69; Region: Peptidase_C69; pfam03577 644284003740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 644284003741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284003742 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284003743 DNA-binding interface [nucleotide binding]; DNA binding site 644284003744 putative transposase OrfB; Reviewed; Region: PHA02517 644284003745 HTH-like domain; Region: HTH_21; pfam13276 644284003746 Integrase core domain; Region: rve; pfam00665 644284003747 Integrase core domain; Region: rve_3; pfam13683 644284003748 RelB antitoxin; Region: RelB; cl01171 644284003749 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 644284003750 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 644284003751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284003752 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 644284003753 FeS/SAM binding site; other site 644284003754 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 644284003755 putative transposase OrfB; Reviewed; Region: PHA02517 644284003756 HTH-like domain; Region: HTH_21; pfam13276 644284003757 Integrase core domain; Region: rve; pfam00665 644284003758 Integrase core domain; Region: rve_3; pfam13683 644284003759 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 644284003760 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 644284003761 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 644284003762 catalytic residues [active] 644284003763 catalytic nucleophile [active] 644284003764 Recombinase; Region: Recombinase; pfam07508 644284003765 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 644284003766 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644284003767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003768 Walker A/P-loop; other site 644284003769 ATP binding site [chemical binding]; other site 644284003770 Q-loop/lid; other site 644284003771 ABC transporter signature motif; other site 644284003772 Walker B; other site 644284003773 D-loop; other site 644284003774 H-loop/switch region; other site 644284003775 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284003776 UMP phosphatase; Provisional; Region: PRK10444 644284003777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284003778 active site 644284003779 motif I; other site 644284003780 motif II; other site 644284003781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284003782 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 644284003783 SmpB-tmRNA interface; other site 644284003784 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 644284003785 Peptidase family M23; Region: Peptidase_M23; pfam01551 644284003786 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 644284003787 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 644284003788 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 644284003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003790 Walker A/P-loop; other site 644284003791 ATP binding site [chemical binding]; other site 644284003792 Q-loop/lid; other site 644284003793 ABC transporter signature motif; other site 644284003794 Walker B; other site 644284003795 D-loop; other site 644284003796 H-loop/switch region; other site 644284003797 peptide chain release factor 2; Validated; Region: prfB; PRK00578 644284003798 This domain is found in peptide chain release factors; Region: PCRF; smart00937 644284003799 RF-1 domain; Region: RF-1; pfam00472 644284003800 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 644284003801 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644284003802 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 644284003803 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 644284003804 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 644284003805 ATP binding site [chemical binding]; other site 644284003806 Walker A motif; other site 644284003807 hexamer interface [polypeptide binding]; other site 644284003808 Walker B motif; other site 644284003809 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644284003810 active site 644284003811 substrate binding site [chemical binding]; other site 644284003812 ATP binding site [chemical binding]; other site 644284003813 Phosphotransferase enzyme family; Region: APH; pfam01636 644284003814 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 644284003815 Part of AAA domain; Region: AAA_19; pfam13245 644284003816 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 644284003817 Part of AAA domain; Region: AAA_19; pfam13245 644284003818 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 644284003819 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 644284003820 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 644284003821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 644284003822 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 644284003823 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 644284003824 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 644284003825 ATP binding site [chemical binding]; other site 644284003826 Mg++ binding site [ion binding]; other site 644284003827 motif III; other site 644284003828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284003829 nucleotide binding region [chemical binding]; other site 644284003830 ATP-binding site [chemical binding]; other site 644284003831 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 644284003832 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 644284003833 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 644284003834 active site 644284003835 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 644284003836 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 644284003837 proline aminopeptidase P II; Provisional; Region: PRK10879 644284003838 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 644284003839 active site 644284003840 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 644284003841 MgtE intracellular N domain; Region: MgtE_N; smart00924 644284003842 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 644284003843 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 644284003844 Domain of unknown function DUF59; Region: DUF59; cl00941 644284003845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644284003846 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 644284003847 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 644284003848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284003849 S-adenosylmethionine binding site [chemical binding]; other site 644284003850 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 644284003851 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 644284003852 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 644284003853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 644284003854 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 644284003855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284003856 dimer interface [polypeptide binding]; other site 644284003857 conserved gate region; other site 644284003858 putative PBP binding loops; other site 644284003859 ABC-ATPase subunit interface; other site 644284003860 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 644284003861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284003862 Walker A/P-loop; other site 644284003863 ATP binding site [chemical binding]; other site 644284003864 Q-loop/lid; other site 644284003865 ABC transporter signature motif; other site 644284003866 Walker B; other site 644284003867 D-loop; other site 644284003868 H-loop/switch region; other site 644284003869 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 644284003870 trimer interface [polypeptide binding]; other site 644284003871 dimer interface [polypeptide binding]; other site 644284003872 putative active site [active] 644284003873 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 644284003874 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644284003875 dimer interface [polypeptide binding]; other site 644284003876 putative functional site; other site 644284003877 putative MPT binding site; other site 644284003878 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 644284003879 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 644284003880 ATP binding site [chemical binding]; other site 644284003881 substrate interface [chemical binding]; other site 644284003882 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 644284003883 MPT binding site; other site 644284003884 trimer interface [polypeptide binding]; other site 644284003885 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 644284003886 MoaE homodimer interface [polypeptide binding]; other site 644284003887 MoaD interaction [polypeptide binding]; other site 644284003888 active site residues [active] 644284003889 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 644284003890 MoaE interaction surface [polypeptide binding]; other site 644284003891 MoeB interaction surface [polypeptide binding]; other site 644284003892 thiocarboxylated glycine; other site 644284003893 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 644284003894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284003895 FeS/SAM binding site; other site 644284003896 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 644284003897 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 644284003898 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 644284003899 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 644284003900 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 644284003901 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 644284003902 4Fe-4S binding domain; Region: Fer4; pfam00037 644284003903 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 644284003904 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 644284003905 putative [Fe4-S4] binding site [ion binding]; other site 644284003906 putative molybdopterin cofactor binding site [chemical binding]; other site 644284003907 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 644284003908 putative molybdopterin cofactor binding site; other site 644284003909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284003910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284003911 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 644284003912 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 644284003913 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 644284003914 purine nucleoside phosphorylase; Provisional; Region: PRK08202 644284003915 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 644284003916 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 644284003917 active site 644284003918 substrate binding site [chemical binding]; other site 644284003919 metal binding site [ion binding]; metal-binding site 644284003920 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 644284003921 intersubunit interface [polypeptide binding]; other site 644284003922 active site 644284003923 catalytic residue [active] 644284003924 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 644284003925 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644284003926 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644284003927 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 644284003928 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 644284003929 active site 644284003930 catalytic motif [active] 644284003931 Zn binding site [ion binding]; other site 644284003932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644284003933 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 644284003934 TM-ABC transporter signature motif; other site 644284003935 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 644284003936 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 644284003937 TM-ABC transporter signature motif; other site 644284003938 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 644284003939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 644284003940 Walker A/P-loop; other site 644284003941 ATP binding site [chemical binding]; other site 644284003942 Q-loop/lid; other site 644284003943 ABC transporter signature motif; other site 644284003944 Walker B; other site 644284003945 D-loop; other site 644284003946 H-loop/switch region; other site 644284003947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 644284003948 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 644284003949 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 644284003950 ligand binding site [chemical binding]; other site 644284003951 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 644284003952 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 644284003953 Substrate binding site; other site 644284003954 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 644284003955 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 644284003956 putative catalytic site [active] 644284003957 putative metal binding site [ion binding]; other site 644284003958 putative phosphate binding site [ion binding]; other site 644284003959 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 644284003960 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 644284003961 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 644284003962 homodimer interface [polypeptide binding]; other site 644284003963 NADP binding site [chemical binding]; other site 644284003964 substrate binding site [chemical binding]; other site 644284003965 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 644284003966 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 644284003967 dimer interface [polypeptide binding]; other site 644284003968 active site 644284003969 glycine-pyridoxal phosphate binding site [chemical binding]; other site 644284003970 folate binding site [chemical binding]; other site 644284003971 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 644284003972 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 644284003973 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 644284003974 putative active site [active] 644284003975 putative substrate binding site [chemical binding]; other site 644284003976 putative cosubstrate binding site; other site 644284003977 catalytic site [active] 644284003978 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 644284003979 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 644284003980 dimer interface [polypeptide binding]; other site 644284003981 substrate binding site [chemical binding]; other site 644284003982 ATP binding site [chemical binding]; other site 644284003983 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 644284003984 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 644284003985 thiamine phosphate binding site [chemical binding]; other site 644284003986 active site 644284003987 pyrophosphate binding site [ion binding]; other site 644284003988 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 644284003989 substrate binding site [chemical binding]; other site 644284003990 multimerization interface [polypeptide binding]; other site 644284003991 ATP binding site [chemical binding]; other site 644284003992 maltose O-acetyltransferase; Provisional; Region: PRK10092 644284003993 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 644284003994 active site 644284003995 substrate binding site [chemical binding]; other site 644284003996 trimer interface [polypeptide binding]; other site 644284003997 CoA binding site [chemical binding]; other site 644284003998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284003999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 644284004000 active site 644284004001 phosphorylation site [posttranslational modification] 644284004002 intermolecular recognition site; other site 644284004003 dimerization interface [polypeptide binding]; other site 644284004004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284004005 dimerization interface [polypeptide binding]; other site 644284004006 DNA binding residues [nucleotide binding] 644284004007 PspC domain; Region: PspC; pfam04024 644284004008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284004009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644284004010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644284004011 ATP binding site [chemical binding]; other site 644284004012 Mg2+ binding site [ion binding]; other site 644284004013 G-X-G motif; other site 644284004014 PspC domain; Region: PspC; pfam04024 644284004015 hypothetical protein; Provisional; Region: PRK04233 644284004016 malate dehydrogenase; Provisional; Region: PRK05442 644284004017 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 644284004018 NAD(P) binding site [chemical binding]; other site 644284004019 dimer interface [polypeptide binding]; other site 644284004020 malate binding site [chemical binding]; other site 644284004021 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 644284004022 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 644284004023 active site 644284004024 dimer interface [polypeptide binding]; other site 644284004025 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 644284004026 dimer interface [polypeptide binding]; other site 644284004027 active site 644284004028 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 644284004029 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 644284004030 active site 644284004031 catalytic site [active] 644284004032 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 644284004033 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 644284004034 active site 644284004035 ADP/pyrophosphate binding site [chemical binding]; other site 644284004036 dimerization interface [polypeptide binding]; other site 644284004037 allosteric effector site; other site 644284004038 fructose-1,6-bisphosphate binding site; other site 644284004039 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 644284004040 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 644284004041 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 644284004042 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 644284004043 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 644284004044 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 644284004045 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 644284004046 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 644284004047 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 644284004048 sugar binding site [chemical binding]; other site 644284004049 ATP synthase protein 8; Region: ATP-synt_8; cl03008 644284004050 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 644284004051 CoA binding domain; Region: CoA_binding; smart00881 644284004052 CoA-ligase; Region: Ligase_CoA; pfam00549 644284004053 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 644284004054 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 644284004055 CoA-ligase; Region: Ligase_CoA; pfam00549 644284004056 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 644284004057 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 644284004058 active site 644284004059 catalytic triad [active] 644284004060 oxyanion hole [active] 644284004061 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 644284004062 Part of AAA domain; Region: AAA_19; pfam13245 644284004063 Family description; Region: UvrD_C_2; pfam13538 644284004064 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 644284004065 catalytic site [active] 644284004066 BNR repeat-like domain; Region: BNR_2; pfam13088 644284004067 Asp-box motif; other site 644284004068 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 644284004069 AzlC protein; Region: AzlC; cl00570 644284004070 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284004071 DNA-binding interface [nucleotide binding]; DNA binding site 644284004072 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284004073 DNA-binding interface [nucleotide binding]; DNA binding site 644284004074 SdpI/YhfL protein family; Region: SdpI; pfam13630 644284004075 GMP synthase; Reviewed; Region: guaA; PRK00074 644284004076 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 644284004077 AMP/PPi binding site [chemical binding]; other site 644284004078 candidate oxyanion hole; other site 644284004079 catalytic triad [active] 644284004080 potential glutamine specificity residues [chemical binding]; other site 644284004081 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 644284004082 ATP Binding subdomain [chemical binding]; other site 644284004083 Ligand Binding sites [chemical binding]; other site 644284004084 Dimerization subdomain; other site 644284004085 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 644284004086 Domain of unknown function (DUF955); Region: DUF955; pfam06114 644284004087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284004088 non-specific DNA binding site [nucleotide binding]; other site 644284004089 salt bridge; other site 644284004090 sequence-specific DNA binding site [nucleotide binding]; other site 644284004091 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 644284004092 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 644284004093 active site 644284004094 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 644284004095 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 644284004096 propionate/acetate kinase; Provisional; Region: PRK12379 644284004097 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 644284004098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 644284004099 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 644284004100 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 644284004101 fumarate hydratase; Reviewed; Region: fumC; PRK00485 644284004102 Class II fumarases; Region: Fumarase_classII; cd01362 644284004103 active site 644284004104 tetramer interface [polypeptide binding]; other site 644284004105 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 644284004106 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 644284004107 phosphate binding site [ion binding]; other site 644284004108 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 644284004109 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 644284004110 active site 644284004111 catalytic site [active] 644284004112 substrate binding site [chemical binding]; other site 644284004113 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 644284004114 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 644284004115 catalytic residue [active] 644284004116 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 644284004117 catalytic residues [active] 644284004118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644284004119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644284004120 peroxiredoxin; Region: AhpC; TIGR03137 644284004121 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 644284004122 dimer interface [polypeptide binding]; other site 644284004123 decamer (pentamer of dimers) interface [polypeptide binding]; other site 644284004124 catalytic triad [active] 644284004125 peroxidatic and resolving cysteines [active] 644284004126 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 644284004127 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 644284004128 active site 644284004129 Transcription factor WhiB; Region: Whib; pfam02467 644284004130 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 644284004131 oligomerisation interface [polypeptide binding]; other site 644284004132 mobile loop; other site 644284004133 roof hairpin; other site 644284004134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284004135 S-adenosylmethionine binding site [chemical binding]; other site 644284004136 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 644284004137 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 644284004138 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 644284004139 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 644284004140 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 644284004141 L-aspartate oxidase; Provisional; Region: PRK06175 644284004142 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 644284004143 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 644284004144 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 644284004145 putative Iron-sulfur protein interface [polypeptide binding]; other site 644284004146 proximal heme binding site [chemical binding]; other site 644284004147 distal heme binding site [chemical binding]; other site 644284004148 putative dimer interface [polypeptide binding]; other site 644284004149 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 644284004150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284004151 Coenzyme A binding pocket [chemical binding]; other site 644284004152 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 644284004153 Glycoprotease family; Region: Peptidase_M22; pfam00814 644284004154 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 644284004155 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 644284004156 alanine racemase; Reviewed; Region: alr; PRK00053 644284004157 active site 644284004158 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644284004159 dimer interface [polypeptide binding]; other site 644284004160 substrate binding site [chemical binding]; other site 644284004161 catalytic residues [active] 644284004162 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 644284004163 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 644284004164 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 644284004165 glutaminase active site [active] 644284004166 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644284004167 dimer interface [polypeptide binding]; other site 644284004168 active site 644284004169 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 644284004170 dimer interface [polypeptide binding]; other site 644284004171 active site 644284004172 pantothenate kinase; Provisional; Region: PRK05439 644284004173 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 644284004174 ATP-binding site [chemical binding]; other site 644284004175 CoA-binding site [chemical binding]; other site 644284004176 Mg2+-binding site [ion binding]; other site 644284004177 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 644284004178 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 644284004179 active site 644284004180 substrate binding site [chemical binding]; other site 644284004181 metal binding site [ion binding]; metal-binding site 644284004182 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 644284004183 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 644284004184 23S rRNA interface [nucleotide binding]; other site 644284004185 L3 interface [polypeptide binding]; other site 644284004186 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 644284004187 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 644284004188 dimerization interface 3.5A [polypeptide binding]; other site 644284004189 active site 644284004190 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644284004191 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 644284004192 nucleotide binding site [chemical binding]; other site 644284004193 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 644284004194 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 644284004195 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 644284004196 alphaNTD homodimer interface [polypeptide binding]; other site 644284004197 alphaNTD - beta interaction site [polypeptide binding]; other site 644284004198 alphaNTD - beta' interaction site [polypeptide binding]; other site 644284004199 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 644284004200 30S ribosomal protein S11; Validated; Region: PRK05309 644284004201 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 644284004202 30S ribosomal protein S13; Region: bact_S13; TIGR03631 644284004203 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 644284004204 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 644284004205 rRNA binding site [nucleotide binding]; other site 644284004206 predicted 30S ribosome binding site; other site 644284004207 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 644284004208 oxidoreductase; Provisional; Region: PRK10015 644284004209 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 644284004210 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 644284004211 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 644284004212 Ligand Binding Site [chemical binding]; other site 644284004213 Electron transfer flavoprotein domain; Region: ETF; pfam01012 644284004214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284004215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284004216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 644284004217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284004218 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 644284004219 putative substrate translocation pore; other site 644284004220 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 644284004221 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 644284004222 active site 2 [active] 644284004223 active site 1 [active] 644284004224 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 644284004225 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 644284004226 acyl-activating enzyme (AAE) consensus motif; other site 644284004227 putative AMP binding site [chemical binding]; other site 644284004228 putative active site [active] 644284004229 putative CoA binding site [chemical binding]; other site 644284004230 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 644284004231 CoA-transferase family III; Region: CoA_transf_3; pfam02515 644284004232 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 644284004233 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 644284004234 active site 644284004235 acetyl esterase; Provisional; Region: PRK10162 644284004236 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 644284004237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644284004238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284004239 putative substrate translocation pore; other site 644284004240 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 644284004241 active site 644284004242 adenylate kinase; Reviewed; Region: adk; PRK00279 644284004243 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 644284004244 AMP-binding site [chemical binding]; other site 644284004245 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 644284004246 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 644284004247 SecY translocase; Region: SecY; pfam00344 644284004248 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 644284004249 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 644284004250 23S rRNA binding site [nucleotide binding]; other site 644284004251 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 644284004252 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 644284004253 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 644284004254 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 644284004255 23S rRNA interface [nucleotide binding]; other site 644284004256 5S rRNA interface [nucleotide binding]; other site 644284004257 L27 interface [polypeptide binding]; other site 644284004258 L5 interface [polypeptide binding]; other site 644284004259 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 644284004260 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644284004261 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644284004262 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 644284004263 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 644284004264 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 644284004265 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 644284004266 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 644284004267 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 644284004268 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 644284004269 RNA binding site [nucleotide binding]; other site 644284004270 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 644284004271 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 644284004272 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 644284004273 putative translocon interaction site; other site 644284004274 23S rRNA interface [nucleotide binding]; other site 644284004275 signal recognition particle (SRP54) interaction site; other site 644284004276 L23 interface [polypeptide binding]; other site 644284004277 trigger factor interaction site; other site 644284004278 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 644284004279 23S rRNA interface [nucleotide binding]; other site 644284004280 5S rRNA interface [nucleotide binding]; other site 644284004281 putative antibiotic binding site [chemical binding]; other site 644284004282 L25 interface [polypeptide binding]; other site 644284004283 L27 interface [polypeptide binding]; other site 644284004284 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 644284004285 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 644284004286 G-X-X-G motif; other site 644284004287 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 644284004288 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 644284004289 putative translocon binding site; other site 644284004290 protein-rRNA interface [nucleotide binding]; other site 644284004291 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 644284004292 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 644284004293 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 644284004294 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 644284004295 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 644284004296 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 644284004297 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 644284004298 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 644284004299 elongation factor Tu; Reviewed; Region: PRK00049 644284004300 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 644284004301 G1 box; other site 644284004302 GEF interaction site [polypeptide binding]; other site 644284004303 GTP/Mg2+ binding site [chemical binding]; other site 644284004304 Switch I region; other site 644284004305 G2 box; other site 644284004306 G3 box; other site 644284004307 Switch II region; other site 644284004308 G4 box; other site 644284004309 G5 box; other site 644284004310 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 644284004311 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 644284004312 Antibiotic Binding Site [chemical binding]; other site 644284004313 elongation factor G; Reviewed; Region: PRK00007 644284004314 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 644284004315 G1 box; other site 644284004316 putative GEF interaction site [polypeptide binding]; other site 644284004317 GTP/Mg2+ binding site [chemical binding]; other site 644284004318 Switch I region; other site 644284004319 G2 box; other site 644284004320 G3 box; other site 644284004321 Switch II region; other site 644284004322 G4 box; other site 644284004323 G5 box; other site 644284004324 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 644284004325 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 644284004326 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 644284004327 30S ribosomal protein S7; Validated; Region: PRK05302 644284004328 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 644284004329 S17 interaction site [polypeptide binding]; other site 644284004330 S8 interaction site; other site 644284004331 16S rRNA interaction site [nucleotide binding]; other site 644284004332 streptomycin interaction site [chemical binding]; other site 644284004333 23S rRNA interaction site [nucleotide binding]; other site 644284004334 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 644284004335 PAS domain; Region: PAS_9; pfam13426 644284004336 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 644284004337 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 644284004338 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 644284004339 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 644284004340 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 644284004341 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 644284004342 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 644284004343 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 644284004344 G-loop; other site 644284004345 DNA binding site [nucleotide binding] 644284004346 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 644284004347 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 644284004348 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644284004349 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644284004350 RPB10 interaction site [polypeptide binding]; other site 644284004351 RPB1 interaction site [polypeptide binding]; other site 644284004352 RPB11 interaction site [polypeptide binding]; other site 644284004353 RPB3 interaction site [polypeptide binding]; other site 644284004354 RPB12 interaction site [polypeptide binding]; other site 644284004355 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 644284004356 L11 interface [polypeptide binding]; other site 644284004357 putative EF-Tu interaction site [polypeptide binding]; other site 644284004358 putative EF-G interaction site [polypeptide binding]; other site 644284004359 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 644284004360 23S rRNA interface [nucleotide binding]; other site 644284004361 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 644284004362 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 644284004363 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 644284004364 ATP-binding site [chemical binding]; other site 644284004365 Sugar specificity; other site 644284004366 Pyrimidine base specificity; other site 644284004367 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 644284004368 mRNA/rRNA interface [nucleotide binding]; other site 644284004369 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 644284004370 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 644284004371 23S rRNA interface [nucleotide binding]; other site 644284004372 L7/L12 interface [polypeptide binding]; other site 644284004373 putative thiostrepton binding site; other site 644284004374 L25 interface [polypeptide binding]; other site 644284004375 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 644284004376 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 644284004377 putative homodimer interface [polypeptide binding]; other site 644284004378 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 644284004379 heterodimer interface [polypeptide binding]; other site 644284004380 homodimer interface [polypeptide binding]; other site 644284004381 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 644284004382 aspartate aminotransferase; Provisional; Region: PRK05764 644284004383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644284004384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644284004385 homodimer interface [polypeptide binding]; other site 644284004386 catalytic residue [active] 644284004387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644284004388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644284004389 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644284004390 Phosphotransferase enzyme family; Region: APH; pfam01636 644284004391 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 644284004392 adenosine deaminase; Provisional; Region: PRK09358 644284004393 active site 644284004394 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644284004395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644284004396 PGAP1-like protein; Region: PGAP1; pfam07819 644284004397 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 644284004398 FAD binding domain; Region: FAD_binding_4; pfam01565 644284004399 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 644284004400 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 644284004401 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 644284004402 ferredoxin-NADP+ reductase; Region: PLN02852 644284004403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644284004404 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 644284004405 30S subunit binding site; other site 644284004406 lipoprotein LpqB; Provisional; Region: PRK13614 644284004407 Sporulation and spore germination; Region: Germane; pfam10646 644284004408 sensor kinase CusS; Provisional; Region: PRK09835 644284004409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644284004410 dimerization interface [polypeptide binding]; other site 644284004411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644284004412 dimer interface [polypeptide binding]; other site 644284004413 phosphorylation site [posttranslational modification] 644284004414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284004415 ATP binding site [chemical binding]; other site 644284004416 Mg2+ binding site [ion binding]; other site 644284004417 G-X-G motif; other site 644284004418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284004419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284004420 active site 644284004421 phosphorylation site [posttranslational modification] 644284004422 intermolecular recognition site; other site 644284004423 dimerization interface [polypeptide binding]; other site 644284004424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284004425 DNA binding site [nucleotide binding] 644284004426 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 644284004427 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 644284004428 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 644284004429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644284004430 Transcription factor WhiB; Region: Whib; pfam02467 644284004431 TIGR03089 family protein; Region: TIGR03089 644284004432 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 644284004433 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 644284004434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644284004435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644284004436 dimer interface [polypeptide binding]; other site 644284004437 phosphorylation site [posttranslational modification] 644284004438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284004439 ATP binding site [chemical binding]; other site 644284004440 Mg2+ binding site [ion binding]; other site 644284004441 G-X-G motif; other site 644284004442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284004443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284004444 active site 644284004445 phosphorylation site [posttranslational modification] 644284004446 intermolecular recognition site; other site 644284004447 dimerization interface [polypeptide binding]; other site 644284004448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284004449 DNA binding site [nucleotide binding] 644284004450 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 644284004451 cyclase homology domain; Region: CHD; cd07302 644284004452 nucleotidyl binding site; other site 644284004453 metal binding site [ion binding]; metal-binding site 644284004454 dimer interface [polypeptide binding]; other site 644284004455 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 644284004456 Maf-like protein; Region: Maf; pfam02545 644284004457 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 644284004458 active site 644284004459 dimer interface [polypeptide binding]; other site 644284004460 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 644284004461 dimer interface [polypeptide binding]; other site 644284004462 Citrate synthase; Region: Citrate_synt; pfam00285 644284004463 active site 644284004464 citrylCoA binding site [chemical binding]; other site 644284004465 NADH binding [chemical binding]; other site 644284004466 cationic pore residues; other site 644284004467 oxalacetate/citrate binding site [chemical binding]; other site 644284004468 coenzyme A binding site [chemical binding]; other site 644284004469 catalytic triad [active] 644284004470 Ferredoxin [Energy production and conversion]; Region: COG1146 644284004471 4Fe-4S binding domain; Region: Fer4; pfam00037 644284004472 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 644284004473 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 644284004474 VanW like protein; Region: VanW; pfam04294 644284004475 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 644284004476 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 644284004477 G1 box; other site 644284004478 putative GEF interaction site [polypeptide binding]; other site 644284004479 GTP/Mg2+ binding site [chemical binding]; other site 644284004480 Switch I region; other site 644284004481 G2 box; other site 644284004482 G3 box; other site 644284004483 Switch II region; other site 644284004484 G4 box; other site 644284004485 G5 box; other site 644284004486 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 644284004487 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 644284004488 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 644284004489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284004490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284004491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004492 Walker A/P-loop; other site 644284004493 ATP binding site [chemical binding]; other site 644284004494 Q-loop/lid; other site 644284004495 ABC transporter signature motif; other site 644284004496 Walker B; other site 644284004497 D-loop; other site 644284004498 H-loop/switch region; other site 644284004499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284004500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284004501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004502 Q-loop/lid; other site 644284004503 ABC transporter signature motif; other site 644284004504 Walker B; other site 644284004505 D-loop; other site 644284004506 H-loop/switch region; other site 644284004507 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 644284004508 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 644284004509 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 644284004510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284004511 Walker A/P-loop; other site 644284004512 ATP binding site [chemical binding]; other site 644284004513 Q-loop/lid; other site 644284004514 ABC transporter signature motif; other site 644284004515 Walker B; other site 644284004516 D-loop; other site 644284004517 H-loop/switch region; other site 644284004518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644284004519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 644284004520 Walker A/P-loop; other site 644284004521 ATP binding site [chemical binding]; other site 644284004522 Q-loop/lid; other site 644284004523 ABC transporter signature motif; other site 644284004524 Walker B; other site 644284004525 D-loop; other site 644284004526 H-loop/switch region; other site 644284004527 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 644284004528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644284004529 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644284004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284004531 dimer interface [polypeptide binding]; other site 644284004532 conserved gate region; other site 644284004533 ABC-ATPase subunit interface; other site 644284004534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644284004535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644284004536 dimer interface [polypeptide binding]; other site 644284004537 conserved gate region; other site 644284004538 putative PBP binding loops; other site 644284004539 ABC-ATPase subunit interface; other site 644284004540 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 644284004541 lipoyl synthase; Provisional; Region: PRK05481 644284004542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 644284004543 FeS/SAM binding site; other site 644284004544 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 644284004545 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 644284004546 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 644284004547 acyl-activating enzyme (AAE) consensus motif; other site 644284004548 putative AMP binding site [chemical binding]; other site 644284004549 putative active site [active] 644284004550 putative CoA binding site [chemical binding]; other site 644284004551 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 644284004552 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 644284004553 active site 644284004554 metal binding site [ion binding]; metal-binding site 644284004555 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644284004556 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 644284004557 active site 644284004558 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 644284004559 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 644284004560 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 644284004561 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 644284004562 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 644284004563 NAD binding site [chemical binding]; other site 644284004564 dimer interface [polypeptide binding]; other site 644284004565 substrate binding site [chemical binding]; other site 644284004566 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644284004567 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644284004568 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 644284004569 Tic20-like protein; Region: Tic20; pfam09685 644284004570 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 644284004571 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 644284004572 metal binding site [ion binding]; metal-binding site 644284004573 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 644284004574 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 644284004575 active site turn [active] 644284004576 phosphorylation site [posttranslational modification] 644284004577 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644284004578 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644284004579 HPr interaction site; other site 644284004580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644284004581 active site 644284004582 phosphorylation site [posttranslational modification] 644284004583 transcriptional antiterminator BglG; Provisional; Region: PRK09772 644284004584 CAT RNA binding domain; Region: CAT_RBD; smart01061 644284004585 PRD domain; Region: PRD; pfam00874 644284004586 PRD domain; Region: PRD; pfam00874 644284004587 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 644284004588 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644284004589 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 644284004590 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 644284004591 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644284004592 dimerization domain swap beta strand [polypeptide binding]; other site 644284004593 regulatory protein interface [polypeptide binding]; other site 644284004594 active site 644284004595 regulatory phosphorylation site [posttranslational modification]; other site 644284004596 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 644284004597 Predicted flavoprotein [General function prediction only]; Region: COG0431 644284004598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644284004599 active site residue [active] 644284004600 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 644284004601 Ferritin-like domain; Region: Ferritin; pfam00210 644284004602 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 644284004603 dimerization interface [polypeptide binding]; other site 644284004604 DPS ferroxidase diiron center [ion binding]; other site 644284004605 ion pore; other site 644284004606 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 644284004607 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 644284004608 CAAX protease self-immunity; Region: Abi; pfam02517 644284004609 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 644284004610 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 644284004611 catalytic residues [active] 644284004612 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 644284004613 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 644284004614 ResB-like family; Region: ResB; pfam05140 644284004615 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 644284004616 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 644284004617 TPR repeat; Region: TPR_11; pfam13414 644284004618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644284004619 binding surface 644284004620 TPR motif; other site 644284004621 TPR repeat; Region: TPR_11; pfam13414 644284004622 Cytochrome c552; Region: Cytochrom_C552; pfam02335 644284004623 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 644284004624 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 644284004625 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 644284004626 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 644284004627 Zn2+ binding site [ion binding]; other site 644284004628 intersubunit interface [polypeptide binding]; other site 644284004629 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284004630 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284004631 DNA binding site [nucleotide binding] 644284004632 domain linker motif; other site 644284004633 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644284004634 dimerization interface [polypeptide binding]; other site 644284004635 ligand binding site [chemical binding]; other site 644284004636 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 644284004637 active site 644284004638 SUMO-1 interface [polypeptide binding]; other site 644284004639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644284004640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644284004641 Coenzyme A binding pocket [chemical binding]; other site 644284004642 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 644284004643 Predicted transcriptional regulators [Transcription]; Region: COG1695 644284004644 Transcriptional regulator PadR-like family; Region: PadR; cl17335 644284004645 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 644284004646 Na2 binding site [ion binding]; other site 644284004647 putative substrate binding site 1 [chemical binding]; other site 644284004648 Na binding site 1 [ion binding]; other site 644284004649 putative substrate binding site 2 [chemical binding]; other site 644284004650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644284004651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004652 Walker A/P-loop; other site 644284004653 ATP binding site [chemical binding]; other site 644284004654 Q-loop/lid; other site 644284004655 ABC transporter signature motif; other site 644284004656 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 644284004657 Sulfatase; Region: Sulfatase; cl17466 644284004658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 644284004659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 644284004660 DNA binding site [nucleotide binding] 644284004661 domain linker motif; other site 644284004662 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644284004663 ligand binding site [chemical binding]; other site 644284004664 dimerization interface [polypeptide binding]; other site 644284004665 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 644284004666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284004667 putative substrate translocation pore; other site 644284004668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284004669 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 644284004670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284004671 FeS/SAM binding site; other site 644284004672 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 644284004673 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644284004674 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 644284004675 active site 644284004676 NTP binding site [chemical binding]; other site 644284004677 metal binding triad [ion binding]; metal-binding site 644284004678 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 644284004679 GTP-binding protein YchF; Reviewed; Region: PRK09601 644284004680 YchF GTPase; Region: YchF; cd01900 644284004681 G1 box; other site 644284004682 GTP/Mg2+ binding site [chemical binding]; other site 644284004683 Switch I region; other site 644284004684 G2 box; other site 644284004685 Switch II region; other site 644284004686 G3 box; other site 644284004687 G4 box; other site 644284004688 G5 box; other site 644284004689 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 644284004690 RmuC family; Region: RmuC; pfam02646 644284004691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644284004692 non-specific DNA binding site [nucleotide binding]; other site 644284004693 salt bridge; other site 644284004694 sequence-specific DNA binding site [nucleotide binding]; other site 644284004695 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 644284004696 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 644284004697 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 644284004698 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 644284004699 generic binding surface II; other site 644284004700 generic binding surface I; other site 644284004701 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 644284004702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644284004703 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 644284004704 putative substrate binding site [chemical binding]; other site 644284004705 putative ATP binding site [chemical binding]; other site 644284004706 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 644284004707 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 644284004708 catalytic residue [active] 644284004709 putative FPP diphosphate binding site; other site 644284004710 putative FPP binding hydrophobic cleft; other site 644284004711 dimer interface [polypeptide binding]; other site 644284004712 putative IPP diphosphate binding site; other site 644284004713 Haemolysin-III related; Region: HlyIII; pfam03006 644284004714 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 644284004715 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 644284004716 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644284004717 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644284004718 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 644284004719 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 644284004720 Bax inhibitor 1 like; Region: BaxI_1; cl17691 644284004721 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 644284004722 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 644284004723 Walker A/P-loop; other site 644284004724 ATP binding site [chemical binding]; other site 644284004725 Q-loop/lid; other site 644284004726 ABC transporter signature motif; other site 644284004727 Walker B; other site 644284004728 D-loop; other site 644284004729 H-loop/switch region; other site 644284004730 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 644284004731 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 644284004732 exopolyphosphatase; Region: exo_poly_only; TIGR03706 644284004733 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 644284004734 Protein of unknown function (DUF501); Region: DUF501; pfam04417 644284004735 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 644284004736 Septum formation initiator; Region: DivIC; pfam04977 644284004737 enolase; Provisional; Region: eno; PRK00077 644284004738 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 644284004739 dimer interface [polypeptide binding]; other site 644284004740 metal binding site [ion binding]; metal-binding site 644284004741 substrate binding pocket [chemical binding]; other site 644284004742 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 644284004743 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 644284004744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284004745 ATP binding site [chemical binding]; other site 644284004746 putative Mg++ binding site [ion binding]; other site 644284004747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284004748 nucleotide binding region [chemical binding]; other site 644284004749 ATP-binding site [chemical binding]; other site 644284004750 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 644284004751 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 644284004752 putative active site [active] 644284004753 catalytic residue [active] 644284004754 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 644284004755 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 644284004756 5S rRNA interface [nucleotide binding]; other site 644284004757 CTC domain interface [polypeptide binding]; other site 644284004758 L16 interface [polypeptide binding]; other site 644284004759 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 644284004760 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 644284004761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644284004762 active site 644284004763 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 644284004764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644284004765 active site 644284004766 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 644284004767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284004768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 644284004769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644284004770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004771 Walker A/P-loop; other site 644284004772 ATP binding site [chemical binding]; other site 644284004773 Q-loop/lid; other site 644284004774 ABC transporter signature motif; other site 644284004775 Walker B; other site 644284004776 D-loop; other site 644284004777 H-loop/switch region; other site 644284004778 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 644284004779 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 644284004780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004781 Walker A/P-loop; other site 644284004782 ATP binding site [chemical binding]; other site 644284004783 ABC transporter; Region: ABC_tran; pfam00005 644284004784 Q-loop/lid; other site 644284004785 ABC transporter signature motif; other site 644284004786 Walker B; other site 644284004787 D-loop; other site 644284004788 H-loop/switch region; other site 644284004789 SdpI/YhfL protein family; Region: SdpI; pfam13630 644284004790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284004791 S-adenosylmethionine binding site [chemical binding]; other site 644284004792 Phage-related protein [Function unknown]; Region: COG4722 644284004793 Phage tail protein; Region: Sipho_tail; cl17486 644284004794 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 644284004795 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 644284004796 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 644284004797 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 644284004798 oligomerization interface [polypeptide binding]; other site 644284004799 Phage capsid family; Region: Phage_capsid; pfam05065 644284004800 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 644284004801 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 644284004802 oligomer interface [polypeptide binding]; other site 644284004803 active site residues [active] 644284004804 Phage-related protein [Function unknown]; Region: COG4695 644284004805 Phage portal protein; Region: Phage_portal; pfam04860 644284004806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284004807 putative DNA binding site [nucleotide binding]; other site 644284004808 putative Zn2+ binding site [ion binding]; other site 644284004809 Predicted permeases [General function prediction only]; Region: COG0701 644284004810 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 644284004811 Low molecular weight phosphatase family; Region: LMWPc; cl00105 644284004812 active site 644284004813 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 644284004814 Phage Terminase; Region: Terminase_1; pfam03354 644284004815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284004816 dimerization interface [polypeptide binding]; other site 644284004817 putative DNA binding site [nucleotide binding]; other site 644284004818 putative Zn2+ binding site [ion binding]; other site 644284004819 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 644284004820 Cadmium resistance transporter; Region: Cad; pfam03596 644284004821 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 644284004822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284004823 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284004824 DNA-binding interface [nucleotide binding]; DNA binding site 644284004825 putative transposase OrfB; Reviewed; Region: PHA02517 644284004826 HTH-like domain; Region: HTH_21; pfam13276 644284004827 Integrase core domain; Region: rve; pfam00665 644284004828 Integrase core domain; Region: rve_3; pfam13683 644284004829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284004830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284004831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004832 Walker A/P-loop; other site 644284004833 ATP binding site [chemical binding]; other site 644284004834 Q-loop/lid; other site 644284004835 ABC transporter signature motif; other site 644284004836 Walker B; other site 644284004837 D-loop; other site 644284004838 H-loop/switch region; other site 644284004839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644284004840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 644284004841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 644284004842 Walker A/P-loop; other site 644284004843 ATP binding site [chemical binding]; other site 644284004844 Q-loop/lid; other site 644284004845 ABC transporter signature motif; other site 644284004846 Walker B; other site 644284004847 D-loop; other site 644284004848 H-loop/switch region; other site 644284004849 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644284004850 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644284004851 Walker A/P-loop; other site 644284004852 ATP binding site [chemical binding]; other site 644284004853 Q-loop/lid; other site 644284004854 ABC transporter signature motif; other site 644284004855 Walker B; other site 644284004856 D-loop; other site 644284004857 H-loop/switch region; other site 644284004858 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 644284004859 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 644284004860 Walker A/P-loop; other site 644284004861 ATP binding site [chemical binding]; other site 644284004862 Q-loop/lid; other site 644284004863 ABC transporter signature motif; other site 644284004864 Walker B; other site 644284004865 D-loop; other site 644284004866 H-loop/switch region; other site 644284004867 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 644284004868 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 644284004869 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 644284004870 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 644284004871 catalytic residues [active] 644284004872 Recombinase; Region: Recombinase; pfam07508 644284004873 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 644284004874 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 644284004875 catalytic residues [active] 644284004876 catalytic nucleophile [active] 644284004877 Recombinase; Region: Recombinase; pfam07508 644284004878 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 644284004879 HsdM N-terminal domain; Region: HsdM_N; pfam12161 644284004880 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 644284004881 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 644284004882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644284004883 MarR family; Region: MarR_2; pfam12802 644284004884 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 644284004885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284004886 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 644284004887 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 644284004888 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 644284004889 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 644284004890 HPr interaction site; other site 644284004891 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644284004892 active site 644284004893 phosphorylation site [posttranslational modification] 644284004894 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 644284004895 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 644284004896 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 644284004897 active site turn [active] 644284004898 phosphorylation site [posttranslational modification] 644284004899 CAT RNA binding domain; Region: CAT_RBD; smart01061 644284004900 PRD domain; Region: PRD; pfam00874 644284004901 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 644284004902 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 644284004903 Domain of unknown function (DUF348); Region: DUF348; pfam03990 644284004904 G5 domain; Region: G5; pfam07501 644284004905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644284004906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644284004907 catalytic residue [active] 644284004908 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644284004909 active site 644284004910 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 644284004911 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 644284004912 active site 644284004913 HIGH motif; other site 644284004914 KMSKS motif; other site 644284004915 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 644284004916 tRNA binding surface [nucleotide binding]; other site 644284004917 anticodon binding site; other site 644284004918 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 644284004919 Isochorismatase family; Region: Isochorismatase; pfam00857 644284004920 catalytic triad [active] 644284004921 metal binding site [ion binding]; metal-binding site 644284004922 conserved cis-peptide bond; other site 644284004923 Uncharacterized conserved protein [Function unknown]; Region: COG5646 644284004924 MMPL family; Region: MMPL; pfam03176 644284004925 Predicted methyltransferases [General function prediction only]; Region: COG0313 644284004926 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 644284004927 putative SAM binding site [chemical binding]; other site 644284004928 putative homodimer interface [polypeptide binding]; other site 644284004929 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 644284004930 DsrE/DsrF-like family; Region: DrsE; cl00672 644284004931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644284004932 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 644284004933 Walker A/P-loop; other site 644284004934 ATP binding site [chemical binding]; other site 644284004935 Q-loop/lid; other site 644284004936 ABC transporter signature motif; other site 644284004937 Walker B; other site 644284004938 D-loop; other site 644284004939 H-loop/switch region; other site 644284004940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644284004941 Histidine kinase; Region: HisKA_3; pfam07730 644284004942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284004943 ATP binding site [chemical binding]; other site 644284004944 Mg2+ binding site [ion binding]; other site 644284004945 G-X-G motif; other site 644284004946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284004947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284004948 active site 644284004949 phosphorylation site [posttranslational modification] 644284004950 intermolecular recognition site; other site 644284004951 dimerization interface [polypeptide binding]; other site 644284004952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284004953 DNA binding residues [nucleotide binding] 644284004954 dimerization interface [polypeptide binding]; other site 644284004955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284004956 S-adenosylmethionine binding site [chemical binding]; other site 644284004957 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 644284004958 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 644284004959 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644284004960 dimer interface [polypeptide binding]; other site 644284004961 putative functional site; other site 644284004962 putative MPT binding site; other site 644284004963 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 644284004964 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 644284004965 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 644284004966 hypothetical protein; Validated; Region: PRK01415 644284004967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 644284004968 active site residue [active] 644284004969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644284004970 Ligand Binding Site [chemical binding]; other site 644284004971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644284004972 Ligand Binding Site [chemical binding]; other site 644284004973 NlpC/P60 family; Region: NLPC_P60; pfam00877 644284004974 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 644284004975 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 644284004976 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 644284004977 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644284004978 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 644284004979 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644284004980 Sulfate transporter family; Region: Sulfate_transp; pfam00916 644284004981 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 644284004982 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 644284004983 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 644284004984 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 644284004985 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 644284004986 DNA-binding site [nucleotide binding]; DNA binding site 644284004987 RNA-binding motif; other site 644284004988 Repair protein; Region: Repair_PSII; pfam04536 644284004989 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 644284004990 LabA_like proteins; Region: LabA_like; cd06167 644284004991 putative metal binding site [ion binding]; other site 644284004992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284004993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284004994 active site 644284004995 phosphorylation site [posttranslational modification] 644284004996 intermolecular recognition site; other site 644284004997 dimerization interface [polypeptide binding]; other site 644284004998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284004999 DNA binding site [nucleotide binding] 644284005000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644284005001 dimerization interface [polypeptide binding]; other site 644284005002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644284005003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644284005004 dimer interface [polypeptide binding]; other site 644284005005 phosphorylation site [posttranslational modification] 644284005006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284005007 ATP binding site [chemical binding]; other site 644284005008 Mg2+ binding site [ion binding]; other site 644284005009 G-X-G motif; other site 644284005010 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 644284005011 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644284005012 putative acyl-acceptor binding pocket; other site 644284005013 short chain dehydrogenase; Provisional; Region: PRK05650 644284005014 classical (c) SDRs; Region: SDR_c; cd05233 644284005015 NAD(P) binding site [chemical binding]; other site 644284005016 active site 644284005017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 644284005018 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 644284005019 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 644284005020 ring oligomerisation interface [polypeptide binding]; other site 644284005021 ATP/Mg binding site [chemical binding]; other site 644284005022 stacking interactions; other site 644284005023 hinge regions; other site 644284005024 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 644284005025 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 644284005026 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 644284005027 ligand binding site [chemical binding]; other site 644284005028 active site 644284005029 UGI interface [polypeptide binding]; other site 644284005030 catalytic site [active] 644284005031 TQXA domain; Region: TQXA_dom; TIGR03934 644284005032 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 644284005033 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 644284005034 substrate-cofactor binding pocket; other site 644284005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644284005036 catalytic residue [active] 644284005037 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 644284005038 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644284005039 NAD(P) binding site [chemical binding]; other site 644284005040 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 644284005041 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 644284005042 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644284005043 TrkA-N domain; Region: TrkA_N; pfam02254 644284005044 TrkA-C domain; Region: TrkA_C; pfam02080 644284005045 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 644284005046 amino acid carrier protein; Region: agcS; TIGR00835 644284005047 Thioredoxin; Region: Thioredoxin_4; cl17273 644284005048 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 644284005049 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 644284005050 Catalytic domain of Protein Kinases; Region: PKc; cd00180 644284005051 active site 644284005052 ATP binding site [chemical binding]; other site 644284005053 substrate binding site [chemical binding]; other site 644284005054 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644284005055 substrate binding site [chemical binding]; other site 644284005056 activation loop (A-loop); other site 644284005057 activation loop (A-loop); other site 644284005058 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 644284005059 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 644284005060 Walker A/P-loop; other site 644284005061 ATP binding site [chemical binding]; other site 644284005062 Q-loop/lid; other site 644284005063 ABC transporter signature motif; other site 644284005064 Walker B; other site 644284005065 D-loop; other site 644284005066 H-loop/switch region; other site 644284005067 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 644284005068 recombination protein RecR; Reviewed; Region: recR; PRK00076 644284005069 RecR protein; Region: RecR; pfam02132 644284005070 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 644284005071 putative active site [active] 644284005072 putative metal-binding site [ion binding]; other site 644284005073 tetramer interface [polypeptide binding]; other site 644284005074 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 644284005075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644284005076 Walker A motif; other site 644284005077 ATP binding site [chemical binding]; other site 644284005078 Walker B motif; other site 644284005079 arginine finger; other site 644284005080 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 644284005081 H+ Antiporter protein; Region: 2A0121; TIGR00900 644284005082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005083 putative substrate translocation pore; other site 644284005084 putative transposase OrfB; Reviewed; Region: PHA02517 644284005085 HTH-like domain; Region: HTH_21; pfam13276 644284005086 Integrase core domain; Region: rve; pfam00665 644284005087 Integrase core domain; Region: rve_3; pfam13683 644284005088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284005089 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284005090 DNA-binding interface [nucleotide binding]; DNA binding site 644284005091 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 644284005092 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 644284005093 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 644284005094 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644284005095 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 644284005096 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 644284005097 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 644284005098 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644284005099 active site 644284005100 HIGH motif; other site 644284005101 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644284005102 KMSKS motif; other site 644284005103 tRNA binding surface [nucleotide binding]; other site 644284005104 anticodon binding site; other site 644284005105 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 644284005106 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 644284005107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005108 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 644284005109 homotrimer interaction site [polypeptide binding]; other site 644284005110 zinc binding site [ion binding]; other site 644284005111 CDP-binding sites; other site 644284005112 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 644284005113 substrate binding site; other site 644284005114 dimer interface; other site 644284005115 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 644284005116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644284005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644284005118 active site 644284005119 phosphorylation site [posttranslational modification] 644284005120 intermolecular recognition site; other site 644284005121 dimerization interface [polypeptide binding]; other site 644284005122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644284005123 DNA binding site [nucleotide binding] 644284005124 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 644284005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644284005126 dimer interface [polypeptide binding]; other site 644284005127 phosphorylation site [posttranslational modification] 644284005128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644284005129 ATP binding site [chemical binding]; other site 644284005130 Mg2+ binding site [ion binding]; other site 644284005131 G-X-G motif; other site 644284005132 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 644284005133 PhoU domain; Region: PhoU; pfam01895 644284005134 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644284005135 catalytic core [active] 644284005136 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 644284005137 hypothetical protein; Provisional; Region: PRK11770 644284005138 Domain of unknown function (DUF307); Region: DUF307; pfam03733 644284005139 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 644284005140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644284005141 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644284005142 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 644284005143 active site residue [active] 644284005144 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 644284005145 putative homotetramer interface [polypeptide binding]; other site 644284005146 putative homodimer interface [polypeptide binding]; other site 644284005147 putative allosteric switch controlling residues; other site 644284005148 putative metal binding site [ion binding]; other site 644284005149 putative homodimer-homodimer interface [polypeptide binding]; other site 644284005150 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644284005151 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 644284005152 xanthine permease; Region: pbuX; TIGR03173 644284005153 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 644284005154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644284005155 putative DNA binding site [nucleotide binding]; other site 644284005156 putative Zn2+ binding site [ion binding]; other site 644284005157 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644284005158 active site 644284005159 DNA binding site [nucleotide binding] 644284005160 Int/Topo IB signature motif; other site 644284005161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284005162 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 644284005163 P-loop; other site 644284005164 Magnesium ion binding site [ion binding]; other site 644284005165 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284005166 Magnesium ion binding site [ion binding]; other site 644284005167 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 644284005168 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 644284005169 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 644284005170 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 644284005171 Walker A motif; other site 644284005172 ATP binding site [chemical binding]; other site 644284005173 Walker B motif; other site 644284005174 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 644284005175 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 644284005176 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 644284005177 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644284005178 catalytic residue [active] 644284005179 CHAP domain; Region: CHAP; pfam05257 644284005180 AAA-like domain; Region: AAA_10; pfam12846 644284005181 Domain of unknown function DUF87; Region: DUF87; pfam01935 644284005182 PrgI family protein; Region: PrgI; pfam12666 644284005183 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 644284005184 DNA binding residues [nucleotide binding] 644284005185 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 644284005186 TAP-like protein; Region: Abhydrolase_4; pfam08386 644284005187 DNA polymerase III subunit delta'; Validated; Region: PRK07940 644284005188 DNA polymerase III subunit delta'; Validated; Region: PRK08485 644284005189 thymidylate kinase; Validated; Region: tmk; PRK00698 644284005190 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 644284005191 TMP-binding site; other site 644284005192 ATP-binding site [chemical binding]; other site 644284005193 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 644284005194 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 644284005195 active site 644284005196 interdomain interaction site; other site 644284005197 putative metal-binding site [ion binding]; other site 644284005198 nucleotide binding site [chemical binding]; other site 644284005199 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 644284005200 domain I; other site 644284005201 phosphate binding site [ion binding]; other site 644284005202 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 644284005203 domain II; other site 644284005204 domain III; other site 644284005205 nucleotide binding site [chemical binding]; other site 644284005206 DNA binding groove [nucleotide binding] 644284005207 catalytic site [active] 644284005208 domain IV; other site 644284005209 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 644284005210 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 644284005211 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 644284005212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644284005213 S-adenosylmethionine binding site [chemical binding]; other site 644284005214 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 644284005215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644284005216 FeS/SAM binding site; other site 644284005217 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 644284005218 Class III ribonucleotide reductase; Region: RNR_III; cd01675 644284005219 effector binding site; other site 644284005220 active site 644284005221 Zn binding site [ion binding]; other site 644284005222 glycine loop; other site 644284005223 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 644284005224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284005225 ATP binding site [chemical binding]; other site 644284005226 putative Mg++ binding site [ion binding]; other site 644284005227 helicase superfamily c-terminal domain; Region: HELICc; smart00490 644284005228 nucleotide binding region [chemical binding]; other site 644284005229 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 644284005230 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 644284005231 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 644284005232 Type II/IV secretion system protein; Region: T2SE; pfam00437 644284005233 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 644284005234 ATP binding site [chemical binding]; other site 644284005235 Walker A motif; other site 644284005236 hexamer interface [polypeptide binding]; other site 644284005237 Walker B motif; other site 644284005238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 644284005239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 644284005240 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 644284005241 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644284005242 minor groove reading motif; other site 644284005243 helix-hairpin-helix signature motif; other site 644284005244 substrate binding pocket [chemical binding]; other site 644284005245 active site 644284005246 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 644284005247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 644284005248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644284005249 ligand binding site [chemical binding]; other site 644284005250 flexible hinge region; other site 644284005251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644284005252 putative switch regulator; other site 644284005253 non-specific DNA interactions [nucleotide binding]; other site 644284005254 DNA binding site [nucleotide binding] 644284005255 sequence specific DNA binding site [nucleotide binding]; other site 644284005256 putative cAMP binding site [chemical binding]; other site 644284005257 Predicted membrane protein (DUF2101); Region: DUF2101; cl01648 644284005258 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 644284005259 homotrimer interaction site [polypeptide binding]; other site 644284005260 putative active site [active] 644284005261 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 644284005262 Transcription factor WhiB; Region: Whib; pfam02467 644284005263 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 644284005264 Transglycosylase; Region: Transgly; pfam00912 644284005265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 644284005266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644284005267 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 644284005268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644284005269 active site 644284005270 metal binding site [ion binding]; metal-binding site 644284005271 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 644284005272 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 644284005273 substrate binding site [chemical binding]; other site 644284005274 dimer interface [polypeptide binding]; other site 644284005275 ATP binding site [chemical binding]; other site 644284005276 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 644284005277 active site 644284005278 catalytic residues [active] 644284005279 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 644284005280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005281 putative substrate translocation pore; other site 644284005282 Abi-like protein; Region: Abi_2; cl01988 644284005283 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 644284005284 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 644284005285 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 644284005286 Cna protein B-type domain; Region: Cna_B; pfam05738 644284005287 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644284005288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644284005289 Soluble P-type ATPase [General function prediction only]; Region: COG4087 644284005290 hypothetical protein; Provisional; Region: PRK13663 644284005291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 644284005292 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 644284005293 active site 644284005294 catalytic residues [active] 644284005295 metal binding site [ion binding]; metal-binding site 644284005296 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 644284005297 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 644284005298 nucleoside/Zn binding site; other site 644284005299 dimer interface [polypeptide binding]; other site 644284005300 catalytic motif [active] 644284005301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644284005302 active site 644284005303 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 644284005304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 644284005305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644284005306 active site 644284005307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644284005308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644284005309 dimerization interface [polypeptide binding]; other site 644284005310 DNA binding residues [nucleotide binding] 644284005311 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 644284005312 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 644284005313 seryl-tRNA synthetase; Provisional; Region: PRK05431 644284005314 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 644284005315 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 644284005316 dimer interface [polypeptide binding]; other site 644284005317 active site 644284005318 motif 1; other site 644284005319 motif 2; other site 644284005320 motif 3; other site 644284005321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644284005322 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644284005323 active site 644284005324 motif I; other site 644284005325 motif II; other site 644284005326 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 644284005327 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 644284005328 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 644284005329 Uncharacterized conserved protein [Function unknown]; Region: COG2128 644284005330 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 644284005331 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 644284005332 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348 644284005333 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 644284005334 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 644284005335 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 644284005336 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 644284005337 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 644284005338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 644284005339 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 644284005340 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 644284005341 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 644284005342 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644284005343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644284005344 DNA-binding site [nucleotide binding]; DNA binding site 644284005345 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 644284005346 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 644284005347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005349 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 644284005350 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 644284005351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644284005352 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 644284005353 putative substrate translocation pore; other site 644284005354 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 644284005355 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 644284005356 transmembrane helices; other site 644284005357 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 644284005358 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 644284005359 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644284005360 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 644284005361 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 644284005362 catalytic triad [active] 644284005363 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 644284005364 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 644284005365 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 644284005366 putative transposase OrfB; Reviewed; Region: PHA02517 644284005367 HTH-like domain; Region: HTH_21; pfam13276 644284005368 Integrase core domain; Region: rve; pfam00665 644284005369 Integrase core domain; Region: rve_3; pfam13683 644284005370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 644284005371 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 644284005372 DNA-binding interface [nucleotide binding]; DNA binding site 644284005373 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 644284005374 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644284005375 ATP binding site [chemical binding]; other site 644284005376 putative Mg++ binding site [ion binding]; other site 644284005377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644284005378 nucleotide binding region [chemical binding]; other site 644284005379 ATP-binding site [chemical binding]; other site 644284005380 Helicase associated domain (HA2); Region: HA2; pfam04408 644284005381 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 644284005382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644284005383 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 644284005384 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 644284005385 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 644284005386 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644284005387 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 644284005388 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 644284005389 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 644284005390 putative acyl-acceptor binding pocket; other site 644284005391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 644284005392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 644284005393 active site 644284005394 catalytic tetrad [active] 644284005395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644284005396 Zn2+ binding site [ion binding]; other site 644284005397 Mg2+ binding site [ion binding]; other site 644284005398 replicative DNA helicase; Region: DnaB; TIGR00665 644284005399 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 644284005400 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 644284005401 Walker A motif; other site 644284005402 ATP binding site [chemical binding]; other site 644284005403 Walker B motif; other site 644284005404 DNA binding loops [nucleotide binding] 644284005405 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 644284005406 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 644284005407 TQXA domain; Region: TQXA_dom; TIGR03934 644284005408 TQXA domain; Region: TQXA_dom; TIGR03934 644284005409 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 644284005410 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 644284005411 active site 644284005412 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 644284005413 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 644284005414 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 644284005415 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 644284005416 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 644284005417 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644284005418 dimer interface [polypeptide binding]; other site 644284005419 ssDNA binding site [nucleotide binding]; other site 644284005420 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644284005421 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 644284005422 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 644284005423 Transglycosylase; Region: Transgly; pfam00912 644284005424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 644284005425 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 644284005426 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644284005427 H+ Antiporter protein; Region: 2A0121; TIGR00900 644284005428 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 644284005429 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 644284005430 active site 644284005431 NTP binding site [chemical binding]; other site 644284005432 metal binding triad [ion binding]; metal-binding site 644284005433 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 644284005434 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644284005435 Zn2+ binding site [ion binding]; other site 644284005436 Mg2+ binding site [ion binding]; other site 644284005437 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 644284005438 active site 644284005439 Ap6A binding site [chemical binding]; other site 644284005440 nudix motif; other site 644284005441 metal binding site [ion binding]; metal-binding site 644284005442 Protein kinase domain; Region: Pkinase; pfam00069 644284005443 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 644284005444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 644284005445 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644284005446 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 644284005447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644284005448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644284005449 homodimer interface [polypeptide binding]; other site 644284005450 catalytic residue [active] 644284005451 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 644284005452 ParB-like nuclease domain; Region: ParB; smart00470 644284005453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644284005454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284005455 P-loop; other site 644284005456 Magnesium ion binding site [ion binding]; other site 644284005457 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644284005458 Magnesium ion binding site [ion binding]; other site 644284005459 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 644284005460 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644284005461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644284005462 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644284005463 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 644284005464 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 644284005465 G-X-X-G motif; other site 644284005466 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 644284005467 RxxxH motif; other site 644284005468 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 644284005469 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 644284005470 Haemolytic domain; Region: Haemolytic; pfam01809 644284005471 Ribonuclease P; Region: Ribonuclease_P; cl00457 644284005472 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399