-- dump date   	20140618_204805
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1036172000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1036172000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172000003	Walker A motif; other site
1036172000004	ATP binding site [chemical binding]; other site
1036172000005	Walker B motif; other site
1036172000006	arginine finger; other site
1036172000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1036172000008	DnaA box-binding interface [nucleotide binding]; other site
1036172000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
1036172000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1036172000011	putative DNA binding surface [nucleotide binding]; other site
1036172000012	dimer interface [polypeptide binding]; other site
1036172000013	beta-clamp/clamp loader binding surface; other site
1036172000014	beta-clamp/translesion DNA polymerase binding surface; other site
1036172000015	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1036172000016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172000017	Mg2+ binding site [ion binding]; other site
1036172000018	G-X-G motif; other site
1036172000019	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1036172000020	anchoring element; other site
1036172000021	dimer interface [polypeptide binding]; other site
1036172000022	ATP binding site [chemical binding]; other site
1036172000023	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1036172000024	active site
1036172000025	putative metal-binding site [ion binding]; other site
1036172000026	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1036172000027	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1036172000028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036172000029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036172000030	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1036172000031	Predicted membrane protein [Function unknown]; Region: COG1238
1036172000032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172000033	S-adenosylmethionine binding site [chemical binding]; other site
1036172000034	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036172000035	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1036172000036	Walker A/P-loop; other site
1036172000037	ATP binding site [chemical binding]; other site
1036172000038	Q-loop/lid; other site
1036172000039	ABC transporter signature motif; other site
1036172000040	Walker B; other site
1036172000041	D-loop; other site
1036172000042	H-loop/switch region; other site
1036172000043	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1036172000044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172000045	dimer interface [polypeptide binding]; other site
1036172000046	conserved gate region; other site
1036172000047	putative PBP binding loops; other site
1036172000048	ABC-ATPase subunit interface; other site
1036172000049	TOBE domain; Region: TOBE; cl01440
1036172000050	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1036172000051	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036172000052	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1036172000053	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1036172000054	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1036172000055	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1036172000056	Predicted membrane protein [Function unknown]; Region: COG3174
1036172000057	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
1036172000058	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036172000059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036172000060	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1036172000061	dimerization interface [polypeptide binding]; other site
1036172000062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172000063	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172000064	putative substrate translocation pore; other site
1036172000065	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1036172000066	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036172000067	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036172000068	active site
1036172000069	adenylosuccinate lyase; Provisional; Region: PRK08470
1036172000070	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1036172000071	tetramer interface [polypeptide binding]; other site
1036172000072	active site
1036172000073	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1036172000074	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447
1036172000075	ATP cone domain; Region: ATP-cone; pfam03477
1036172000076	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1036172000077	active site
1036172000078	dimer interface [polypeptide binding]; other site
1036172000079	catalytic residues [active]
1036172000080	effector binding site; other site
1036172000081	R2 peptide binding site; other site
1036172000082	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1036172000083	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1036172000084	dimer interface [polypeptide binding]; other site
1036172000085	putative radical transfer pathway; other site
1036172000086	diiron center [ion binding]; other site
1036172000087	tyrosyl radical; other site
1036172000088	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1036172000089	active site
1036172000090	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172000091	ligand binding site [chemical binding]; other site
1036172000092	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172000093	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1036172000094	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
1036172000095	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1036172000096	NADP binding site [chemical binding]; other site
1036172000097	dimer interface [polypeptide binding]; other site
1036172000098	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036172000099	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036172000100	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1036172000101	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1036172000102	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1036172000103	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1036172000104	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1036172000105	GatB domain; Region: GatB_Yqey; smart00845
1036172000106	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1036172000107	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1036172000108	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1036172000109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172000110	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1036172000111	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1036172000112	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1036172000113	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1036172000114	FAD binding domain; Region: FAD_binding_4; pfam01565
1036172000115	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036172000116	L-lactate permease; Region: Lactate_perm; cl00701
1036172000117	glycolate transporter; Provisional; Region: PRK09695
1036172000118	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172000119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172000120	active site
1036172000121	phosphorylation site [posttranslational modification]
1036172000122	intermolecular recognition site; other site
1036172000123	dimerization interface [polypeptide binding]; other site
1036172000124	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1036172000125	DNA binding site [nucleotide binding]
1036172000126	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1036172000127	PAS fold; Region: PAS_4; pfam08448
1036172000128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172000129	putative active site [active]
1036172000130	heme pocket [chemical binding]; other site
1036172000131	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172000132	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
1036172000133	ATP binding site [chemical binding]; other site
1036172000134	G-X-G motif; other site
1036172000135	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1036172000136	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1036172000137	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1036172000138	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1036172000139	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036172000140	Cysteine-rich domain; Region: CCG; pfam02754
1036172000141	Cysteine-rich domain; Region: CCG; pfam02754
1036172000142	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1036172000143	catalytic motif [active]
1036172000144	Zn binding site [ion binding]; other site
1036172000145	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1036172000146	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036172000147	carboxyltransferase (CT) interaction site; other site
1036172000148	biotinylation site [posttranslational modification]; other site
1036172000149	biotin carboxylase; Validated; Region: PRK08462
1036172000150	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172000151	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172000152	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1036172000153	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1036172000154	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036172000155	ATP binding site [chemical binding]; other site
1036172000156	Mg++ binding site [ion binding]; other site
1036172000157	motif III; other site
1036172000158	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172000159	nucleotide binding region [chemical binding]; other site
1036172000160	ATP-binding site [chemical binding]; other site
1036172000161	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1036172000162	Phosphate transporter family; Region: PHO4; pfam01384
1036172000163	Phosphate transporter family; Region: PHO4; cl00396
1036172000164	Membrane transport protein; Region: Mem_trans; cl09117
1036172000165	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1036172000166	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1036172000167	active site
1036172000168	dimer interface [polypeptide binding]; other site
1036172000169	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1036172000170	Ligand Binding Site [chemical binding]; other site
1036172000171	Molecular Tunnel; other site
1036172000172	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1036172000173	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1036172000174	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1036172000175	putative active site [active]
1036172000176	PhoH-like protein; Region: PhoH; pfam02562
1036172000177	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1036172000178	recombination factor protein RarA; Reviewed; Region: PRK13342
1036172000179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172000180	Walker A motif; other site
1036172000181	ATP binding site [chemical binding]; other site
1036172000182	Walker B motif; other site
1036172000183	arginine finger; other site
1036172000184	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1036172000185	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172000186	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1036172000187	RNA binding surface [nucleotide binding]; other site
1036172000188	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1036172000189	active site
1036172000190	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1036172000191	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1036172000192	putative active site [active]
1036172000193	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1036172000194	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1036172000195	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1036172000196	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1036172000197	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1036172000198	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1036172000199	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1036172000200	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1036172000201	substrate binding site [chemical binding]; other site
1036172000202	glutamase interaction surface [polypeptide binding]; other site
1036172000203	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1036172000204	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1036172000205	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462
1036172000206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1036172000207	FeS/SAM binding site; other site
1036172000208	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036172000209	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1036172000210	active site
1036172000211	HIGH motif; other site
1036172000212	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036172000213	active site
1036172000214	KMSKS motif; other site
1036172000215	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1036172000216	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1036172000217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172000218	active site
1036172000219	phosphorylation site [posttranslational modification]
1036172000220	intermolecular recognition site; other site
1036172000221	dimerization interface [polypeptide binding]; other site
1036172000222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172000223	DNA binding site [nucleotide binding]
1036172000224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172000225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172000226	dimer interface [polypeptide binding]; other site
1036172000227	phosphorylation site [posttranslational modification]
1036172000228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172000229	ATP binding site [chemical binding]; other site
1036172000230	Mg2+ binding site [ion binding]; other site
1036172000231	G-X-G motif; other site
1036172000232	YtkA-like; Region: YtkA; pfam13115
1036172000233	Outer membrane efflux protein; Region: OEP; pfam02321
1036172000234	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172000235	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1036172000236	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1036172000237	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1036172000238	Adhesion protein FadA; Region: FadA; pfam09403
1036172000239	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
1036172000240	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1036172000241	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1036172000242	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1036172000243	active site
1036172000244	dimer interface [polypeptide binding]; other site
1036172000245	motif 1; other site
1036172000246	motif 2; other site
1036172000247	motif 3; other site
1036172000248	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1036172000249	anticodon binding site; other site
1036172000250	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1036172000251	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1036172000252	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1036172000253	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1036172000254	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1036172000255	23S rRNA binding site [nucleotide binding]; other site
1036172000256	L21 binding site [polypeptide binding]; other site
1036172000257	L13 binding site [polypeptide binding]; other site
1036172000258	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172000259	active site residue [active]
1036172000260	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172000261	active site residue [active]
1036172000262	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172000263	active site residue [active]
1036172000264	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1036172000265	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036172000266	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1036172000267	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1036172000268	GTP binding site; other site
1036172000269	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1036172000270	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1036172000271	substrate binding site [chemical binding]; other site
1036172000272	ligand binding site [chemical binding]; other site
1036172000273	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1036172000274	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324
1036172000275	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1036172000276	active site
1036172000277	substrate binding site [chemical binding]; other site
1036172000278	metal binding site [ion binding]; metal-binding site
1036172000279	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1036172000280	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1036172000281	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1036172000282	RF-1 domain; Region: RF-1; pfam00472
1036172000283	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1036172000284	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172000285	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1036172000286	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172000287	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172000288	metal binding site [ion binding]; metal-binding site
1036172000289	active site
1036172000290	I-site; other site
1036172000291	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1036172000292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172000293	dimer interface [polypeptide binding]; other site
1036172000294	conserved gate region; other site
1036172000295	putative PBP binding loops; other site
1036172000296	ABC-ATPase subunit interface; other site
1036172000297	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1036172000298	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1036172000299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172000300	dimer interface [polypeptide binding]; other site
1036172000301	conserved gate region; other site
1036172000302	putative PBP binding loops; other site
1036172000303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036172000304	ABC-ATPase subunit interface; other site
1036172000305	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1036172000306	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1036172000307	Walker A/P-loop; other site
1036172000308	ATP binding site [chemical binding]; other site
1036172000309	Q-loop/lid; other site
1036172000310	ABC transporter signature motif; other site
1036172000311	Walker B; other site
1036172000312	D-loop; other site
1036172000313	H-loop/switch region; other site
1036172000314	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1036172000315	PhoU domain; Region: PhoU; pfam01895
1036172000316	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172000317	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172000318	active site
1036172000319	phosphorylation site [posttranslational modification]
1036172000320	intermolecular recognition site; other site
1036172000321	dimerization interface [polypeptide binding]; other site
1036172000322	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172000323	DNA binding site [nucleotide binding]
1036172000324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172000325	dimer interface [polypeptide binding]; other site
1036172000326	phosphorylation site [posttranslational modification]
1036172000327	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036172000328	ATP binding site [chemical binding]; other site
1036172000329	Mg2+ binding site [ion binding]; other site
1036172000330	G-X-G motif; other site
1036172000331	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1036172000332	23S rRNA interface [nucleotide binding]; other site
1036172000333	L3 interface [polypeptide binding]; other site
1036172000334	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1036172000335	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
1036172000336	peptide binding site [polypeptide binding]; other site
1036172000337	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1036172000338	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1036172000339	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172000340	motif II; other site
1036172000341	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1036172000342	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1036172000343	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1036172000344	Protein of unknown function (DUF330); Region: DUF330; cl01135
1036172000345	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1036172000346	mce related protein; Region: MCE; pfam02470
1036172000347	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1036172000348	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172000349	Walker A/P-loop; other site
1036172000350	ATP binding site [chemical binding]; other site
1036172000351	Q-loop/lid; other site
1036172000352	ABC transporter signature motif; other site
1036172000353	Walker B; other site
1036172000354	D-loop; other site
1036172000355	H-loop/switch region; other site
1036172000356	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1036172000357	Permease; Region: Permease; pfam02405
1036172000358	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172000359	Walker A/P-loop; other site
1036172000360	ATP binding site [chemical binding]; other site
1036172000361	Q-loop/lid; other site
1036172000362	AAA domain; Region: AAA_21; pfam13304
1036172000363	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1036172000364	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
1036172000365	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036172000366	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1036172000367	Predicted membrane protein [Function unknown]; Region: COG2259
1036172000368	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1036172000369	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1036172000370	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1036172000371	substrate binding pocket [chemical binding]; other site
1036172000372	dimer interface [polypeptide binding]; other site
1036172000373	inhibitor binding site; inhibition site
1036172000374	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1036172000375	B12 binding site [chemical binding]; other site
1036172000376	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1036172000377	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1036172000378	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1036172000379	homodimer interface [polypeptide binding]; other site
1036172000380	substrate-cofactor binding pocket; other site
1036172000381	catalytic residue [active]
1036172000382	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1036172000383	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1036172000384	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1036172000385	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1036172000386	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1036172000387	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1036172000388	metal binding site [ion binding]; metal-binding site
1036172000389	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1036172000390	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1036172000391	ThiC family; Region: ThiC; pfam01964
1036172000392	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
1036172000393	HDOD domain; Region: HDOD; pfam08668
1036172000394	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1036172000395	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1036172000396	substrate binding site; other site
1036172000397	dimer interface; other site
1036172000398	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1036172000399	homotrimer interaction site [polypeptide binding]; other site
1036172000400	zinc binding site [ion binding]; other site
1036172000401	CDP-binding sites; other site
1036172000402	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036172000403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172000404	active site
1036172000405	phosphorylation site [posttranslational modification]
1036172000406	dimerization interface [polypeptide binding]; other site
1036172000407	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1036172000408	tetramer interfaces [polypeptide binding]; other site
1036172000409	binuclear metal-binding site [ion binding]; other site
1036172000410	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1036172000411	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1036172000412	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1036172000413	catalytic site [active]
1036172000414	subunit interface [polypeptide binding]; other site
1036172000415	Protein of unknown function (DUF507); Region: DUF507; pfam04368
1036172000416	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1036172000417	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1036172000418	GDP-binding site [chemical binding]; other site
1036172000419	ACT binding site; other site
1036172000420	IMP binding site; other site
1036172000421	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293
1036172000422	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036172000423	motif 1; other site
1036172000424	dimer interface [polypeptide binding]; other site
1036172000425	active site
1036172000426	motif 2; other site
1036172000427	motif 3; other site
1036172000428	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1036172000429	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172000430	catalytic residue [active]
1036172000431	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1036172000432	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036172000433	MarR family; Region: MarR; pfam01047
1036172000434	MarR family; Region: MarR_2; cl17246
1036172000435	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1036172000436	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1036172000437	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1036172000438	putative active site [active]
1036172000439	metal binding site [ion binding]; metal-binding site
1036172000440	Predicted flavoprotein [General function prediction only]; Region: COG0431
1036172000441	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036172000442	Pirin-related protein [General function prediction only]; Region: COG1741
1036172000443	Pirin; Region: Pirin; pfam02678
1036172000444	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1036172000445	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1036172000446	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1036172000447	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1036172000448	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1036172000449	dimerization interface [polypeptide binding]; other site
1036172000450	putative ATP binding site [chemical binding]; other site
1036172000451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036172000452	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1036172000453	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1036172000454	CoA-binding site [chemical binding]; other site
1036172000455	ATP-binding [chemical binding]; other site
1036172000456	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1036172000457	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1036172000458	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1036172000459	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1036172000460	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172000461	ATP-grasp domain; Region: ATP-grasp; pfam02222
1036172000462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172000463	Coenzyme A binding pocket [chemical binding]; other site
1036172000464	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172000465	Sel1-like repeats; Region: SEL1; smart00671
1036172000466	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
1036172000467	genetic element 1
1036172000468	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
1036172000469	rod shape-determining protein MreC; Provisional; Region: PRK13922
1036172000470	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1036172000471	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
1036172000472	Helix-turn-helix domain; Region: HTH_17; pfam12728
1036172000473	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1036172000474	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036172000475	active site
1036172000476	DNA binding site [nucleotide binding]
1036172000477	Int/Topo IB signature motif; other site
1036172000478	prenyltransferase; Reviewed; Region: ubiA; PRK12874
1036172000479	UbiA prenyltransferase family; Region: UbiA; pfam01040
1036172000480	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1036172000481	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1036172000482	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1036172000483	Predicted methyltransferases [General function prediction only]; Region: COG0313
1036172000484	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1036172000485	putative SAM binding site [chemical binding]; other site
1036172000486	putative homodimer interface [polypeptide binding]; other site
1036172000487	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1036172000488	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1036172000489	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1036172000490	aspartate aminotransferase; Provisional; Region: PRK08636
1036172000491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172000492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172000493	homodimer interface [polypeptide binding]; other site
1036172000494	catalytic residue [active]
1036172000495	homoserine dehydrogenase; Provisional; Region: PRK06349
1036172000496	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1036172000497	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1036172000498	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1036172000499	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
1036172000500	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
1036172000501	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1036172000502	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1036172000503	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1036172000504	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1036172000505	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1036172000506	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1036172000507	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1036172000508	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036172000509	UGMP family protein; Validated; Region: PRK09604
1036172000510	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1036172000511	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1036172000512	putative rRNA binding site [nucleotide binding]; other site
1036172000513	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1036172000514	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1036172000515	putative substrate binding site [chemical binding]; other site
1036172000516	putative ATP binding site [chemical binding]; other site
1036172000517	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
1036172000518	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1036172000519	ThiS interaction site; other site
1036172000520	putative active site [active]
1036172000521	tetramer interface [polypeptide binding]; other site
1036172000522	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
1036172000523	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1036172000524	active site
1036172000525	catalytic residues [active]
1036172000526	metal binding site [ion binding]; metal-binding site
1036172000527	homodimer binding site [polypeptide binding]; other site
1036172000528	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1036172000529	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036172000530	carboxyltransferase (CT) interaction site; other site
1036172000531	biotinylation site [posttranslational modification]; other site
1036172000532	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
1036172000533	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172000534	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172000535	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036172000536	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1036172000537	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172000538	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172000539	dimer interface [polypeptide binding]; other site
1036172000540	putative CheW interface [polypeptide binding]; other site
1036172000541	PLD-like domain; Region: PLDc_2; pfam13091
1036172000542	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
1036172000543	putative homodimer interface [polypeptide binding]; other site
1036172000544	putative active site [active]
1036172000545	catalytic site [active]
1036172000546	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1036172000547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172000548	ATP binding site [chemical binding]; other site
1036172000549	putative Mg++ binding site [ion binding]; other site
1036172000550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172000551	nucleotide binding region [chemical binding]; other site
1036172000552	ATP-binding site [chemical binding]; other site
1036172000553	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1036172000554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172000555	putative substrate translocation pore; other site
1036172000556	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172000557	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1036172000558	MarR family; Region: MarR_2; pfam12802
1036172000559	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1036172000560	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1036172000561	TPP-binding site [chemical binding]; other site
1036172000562	dimer interface [polypeptide binding]; other site
1036172000563	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036172000564	PYR/PP interface [polypeptide binding]; other site
1036172000565	dimer interface [polypeptide binding]; other site
1036172000566	TPP binding site [chemical binding]; other site
1036172000567	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036172000568	LrgA family; Region: LrgA; pfam03788
1036172000569	LrgB-like family; Region: LrgB; pfam04172
1036172000570	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1036172000571	putative active site pocket [active]
1036172000572	dimerization interface [polypeptide binding]; other site
1036172000573	putative catalytic residue [active]
1036172000574	Predicted membrane protein [Function unknown]; Region: COG3766
1036172000575	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1036172000576	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1036172000577	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036172000578	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036172000579	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036172000580	DNA binding residues [nucleotide binding]
1036172000581	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
1036172000582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172000583	putative substrate translocation pore; other site
1036172000584	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1036172000585	putative acyl-acceptor binding pocket; other site
1036172000586	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1036172000587	acyl-activating enzyme (AAE) consensus motif; other site
1036172000588	putative AMP binding site [chemical binding]; other site
1036172000589	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1036172000590	metal binding triad; other site
1036172000591	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1036172000592	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
1036172000593	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
1036172000594	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1036172000595	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172000596	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172000597	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172000598	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172000599	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172000600	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172000601	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172000602	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1036172000603	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1036172000604	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1036172000605	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1036172000606	active site
1036172000607	substrate binding pocket [chemical binding]; other site
1036172000608	dimer interface [polypeptide binding]; other site
1036172000609	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1036172000610	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1036172000611	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1036172000612	Flagellar P-ring protein; Region: FlgI; pfam02119
1036172000613	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
1036172000614	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1036172000615	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1036172000616	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
1036172000617	Flagellar L-ring protein; Region: FlgH; pfam02107
1036172000618	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
1036172000619	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172000620	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1036172000621	flagellar protein FliS; Validated; Region: fliS; PRK05685
1036172000622	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1036172000623	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1036172000624	Ligand Binding Site [chemical binding]; other site
1036172000625	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1036172000626	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036172000627	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1036172000628	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1036172000629	active site
1036172000630	ATP-binding site [chemical binding]; other site
1036172000631	pantoate-binding site; other site
1036172000632	HXXH motif; other site
1036172000633	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036172000634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172000635	dimer interface [polypeptide binding]; other site
1036172000636	conserved gate region; other site
1036172000637	putative PBP binding loops; other site
1036172000638	ABC-ATPase subunit interface; other site
1036172000639	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1036172000640	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1036172000641	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1036172000642	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1036172000643	FAD binding site [chemical binding]; other site
1036172000644	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1036172000645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172000646	motif II; other site
1036172000647	Class I aldolases; Region: Aldolase_Class_I; cl17187
1036172000648	transaldolase; Provisional; Region: PRK03903
1036172000649	catalytic residue [active]
1036172000650	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1036172000651	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
1036172000652	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
1036172000653	ArsC family; Region: ArsC; pfam03960
1036172000654	catalytic residue [active]
1036172000655	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1036172000656	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1036172000657	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1036172000658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400
1036172000659	TrkA-C domain; Region: TrkA_C; pfam02080
1036172000660	hypothetical protein; Provisional; Region: PRK05839
1036172000661	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172000662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172000663	homodimer interface [polypeptide binding]; other site
1036172000664	catalytic residue [active]
1036172000665	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1036172000666	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1036172000667	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036172000668	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036172000669	DNA protecting protein DprA; Region: dprA; TIGR00732
1036172000670	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1036172000671	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1036172000672	putative active site [active]
1036172000673	NodB motif; other site
1036172000674	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1036172000675	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1036172000676	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1036172000677	RNB domain; Region: RNB; pfam00773
1036172000678	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1036172000679	FliW protein; Region: FliW; pfam02623
1036172000680	DNA polymerase III subunit delta; Validated; Region: PRK08487
1036172000681	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1036172000682	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1036172000683	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1036172000684	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1036172000685	dimer interface [polypeptide binding]; other site
1036172000686	ssDNA binding site [nucleotide binding]; other site
1036172000687	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036172000688	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1036172000689	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1036172000690	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1036172000691	active site
1036172000692	HIGH motif; other site
1036172000693	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1036172000694	KMSKS motif; other site
1036172000695	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1036172000696	tRNA binding surface [nucleotide binding]; other site
1036172000697	anticodon binding site; other site
1036172000698	transcription elongation factor NusA; Provisional; Region: nusA; PRK12328
1036172000699	NusA N-terminal domain; Region: NusA_N; pfam08529
1036172000700	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1036172000701	RNA binding site [nucleotide binding]; other site
1036172000702	homodimer interface [polypeptide binding]; other site
1036172000703	NusA-like KH domain; Region: KH_5; pfam13184
1036172000704	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1036172000705	G-X-X-G motif; other site
1036172000706	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339
1036172000707	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036172000708	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172000709	FeS/SAM binding site; other site
1036172000710	TRAM domain; Region: TRAM; pfam01938
1036172000711	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1036172000712	putative acyl-acceptor binding pocket; other site
1036172000713	hypothetical protein; Provisional; Region: PRK08444
1036172000714	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172000715	FeS/SAM binding site; other site
1036172000716	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1036172000717	active site clefts [active]
1036172000718	zinc binding site [ion binding]; other site
1036172000719	dimer interface [polypeptide binding]; other site
1036172000720	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1036172000721	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1036172000722	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172000723	catalytic residue [active]
1036172000724	hypothetical protein; Reviewed; Region: PRK12497
1036172000725	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1036172000726	thiS-thiF/thiG interaction site; other site
1036172000727	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172000728	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172000729	ligand binding site [chemical binding]; other site
1036172000730	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
1036172000731	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1036172000732	domain interfaces; other site
1036172000733	active site
1036172000734	acetylornithine aminotransferase; Provisional; Region: PRK02627
1036172000735	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036172000736	inhibitor-cofactor binding pocket; inhibition site
1036172000737	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172000738	catalytic residue [active]
1036172000739	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
1036172000740	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1036172000741	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1036172000742	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1036172000743	para-aminobenzoate synthase component I; Validated; Region: PRK07093
1036172000744	hypothetical protein; Provisional; Region: PRK07101
1036172000745	homodimer interface [polypeptide binding]; other site
1036172000746	substrate-cofactor binding pocket; other site
1036172000747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172000748	catalytic residue [active]
1036172000749	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
1036172000750	PhnA protein; Region: PhnA; pfam03831
1036172000751	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1036172000752	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1036172000753	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036172000754	hypothetical protein; Provisional; Region: PRK10621
1036172000755	HPP family; Region: HPP; pfam04982
1036172000756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1036172000757	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1036172000758	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
1036172000759	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172000760	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172000761	ligand binding site [chemical binding]; other site
1036172000762	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1036172000763	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172000764	MULE transposase domain; Region: MULE; pfam10551
1036172000765	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
1036172000766	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1036172000767	putative ligand binding site [chemical binding]; other site
1036172000768	putative NAD binding site [chemical binding]; other site
1036172000769	catalytic site [active]
1036172000770	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1036172000771	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1036172000772	tetramer interface [polypeptide binding]; other site
1036172000773	active site
1036172000774	Mg2+/Mn2+ binding site [ion binding]; other site
1036172000775	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1036172000776	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
1036172000777	dimer interface [polypeptide binding]; other site
1036172000778	active site
1036172000779	citrylCoA binding site [chemical binding]; other site
1036172000780	oxalacetate/citrate binding site [chemical binding]; other site
1036172000781	coenzyme A binding site [chemical binding]; other site
1036172000782	catalytic triad [active]
1036172000783	aconitate hydratase; Validated; Region: PRK09277
1036172000784	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1036172000785	substrate binding site [chemical binding]; other site
1036172000786	ligand binding site [chemical binding]; other site
1036172000787	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1036172000788	substrate binding site [chemical binding]; other site
1036172000789	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
1036172000790	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
1036172000791	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1036172000792	catalytic triad [active]
1036172000793	dimer interface [polypeptide binding]; other site
1036172000794	Isochorismatase family; Region: Isochorismatase; pfam00857
1036172000795	conserved cis-peptide bond; other site
1036172000796	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1036172000797	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1036172000798	domain interfaces; other site
1036172000799	active site
1036172000800	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1036172000801	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1036172000802	catalytic residues [active]
1036172000803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172000804	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
1036172000805	Walker A motif; other site
1036172000806	ATP binding site [chemical binding]; other site
1036172000807	Walker B motif; other site
1036172000808	arginine finger; other site
1036172000809	glutamate racemase; Provisional; Region: PRK00865
1036172000810	glutamate dehydrogenase; Provisional; Region: PRK09414
1036172000811	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036172000812	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1036172000813	NAD(P) binding site [chemical binding]; other site
1036172000814	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1036172000815	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1036172000816	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1036172000817	RNA binding site [nucleotide binding]; other site
1036172000818	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1036172000819	multimer interface [polypeptide binding]; other site
1036172000820	Walker A motif; other site
1036172000821	ATP binding site [chemical binding]; other site
1036172000822	Walker B motif; other site
1036172000823	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1036172000824	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1036172000825	dimer interface [polypeptide binding]; other site
1036172000826	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1036172000827	catalytic triad [active]
1036172000828	peroxidatic and resolving cysteines [active]
1036172000829	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1036172000830	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1036172000831	active site
1036172000832	multimer interface [polypeptide binding]; other site
1036172000833	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
1036172000834	putative phosphate acyltransferase; Provisional; Region: PRK05331
1036172000835	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1036172000836	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1036172000837	dimer interface [polypeptide binding]; other site
1036172000838	active site
1036172000839	CoA binding pocket [chemical binding]; other site
1036172000840	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1036172000841	GTP/Mg2+ binding site [chemical binding]; other site
1036172000842	G5 box; other site
1036172000843	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1036172000844	Dynamin family; Region: Dynamin_N; pfam00350
1036172000845	G1 box; other site
1036172000846	G1 box; other site
1036172000847	GTP/Mg2+ binding site [chemical binding]; other site
1036172000848	Switch I region; other site
1036172000849	G2 box; other site
1036172000850	G2 box; other site
1036172000851	Switch I region; other site
1036172000852	G3 box; other site
1036172000853	Switch II region; other site
1036172000854	G4 box; other site
1036172000855	G5 box; other site
1036172000856	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1036172000857	Dynamin family; Region: Dynamin_N; pfam00350
1036172000858	G1 box; other site
1036172000859	GTP/Mg2+ binding site [chemical binding]; other site
1036172000860	G2 box; other site
1036172000861	Switch I region; other site
1036172000862	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1036172000863	G3 box; other site
1036172000864	Switch II region; other site
1036172000865	GTP/Mg2+ binding site [chemical binding]; other site
1036172000866	G4 box; other site
1036172000867	G5 box; other site
1036172000868	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
1036172000869	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1036172000870	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036172000871	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
1036172000872	L-aspartate oxidase; Provisional; Region: PRK06175
1036172000873	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036172000874	fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553
1036172000875	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
1036172000876	Iron-sulfur protein interface; other site
1036172000877	proximal heme binding site [chemical binding]; other site
1036172000878	distal heme binding site [chemical binding]; other site
1036172000879	dimer interface [polypeptide binding]; other site
1036172000880	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1036172000881	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036172000882	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1036172000883	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036172000884	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1036172000885	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1036172000886	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036172000887	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1036172000888	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1036172000889	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1036172000890	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1036172000891	4Fe-4S binding domain; Region: Fer4; pfam00037
1036172000892	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1036172000893	NADH dehydrogenase; Region: NADHdh; cl00469
1036172000894	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
1036172000895	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1036172000896	catalytic loop [active]
1036172000897	iron binding site [ion binding]; other site
1036172000898	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1036172000899	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172000900	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172000901	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1036172000902	dimer interface [polypeptide binding]; other site
1036172000903	Citrate synthase; Region: Citrate_synt; pfam00285
1036172000904	active site
1036172000905	citrylCoA binding site [chemical binding]; other site
1036172000906	NADH binding [chemical binding]; other site
1036172000907	cationic pore residues; other site
1036172000908	oxalacetate/citrate binding site [chemical binding]; other site
1036172000909	coenzyme A binding site [chemical binding]; other site
1036172000910	catalytic triad [active]
1036172000911	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1036172000912	SLBB domain; Region: SLBB; pfam10531
1036172000913	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1036172000914	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1036172000915	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1036172000916	putative dimer interface [polypeptide binding]; other site
1036172000917	[2Fe-2S] cluster binding site [ion binding]; other site
1036172000918	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
1036172000919	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1036172000920	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1036172000921	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1036172000922	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1036172000923	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
1036172000924	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172000925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172000926	homodimer interface [polypeptide binding]; other site
1036172000927	catalytic residue [active]
1036172000928	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
1036172000929	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1036172000930	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1036172000931	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1036172000932	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1036172000933	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1036172000934	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1036172000935	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1036172000936	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036172000937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172000938	S-adenosylmethionine binding site [chemical binding]; other site
1036172000939	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172000940	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036172000941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172000942	dimer interface [polypeptide binding]; other site
1036172000943	putative CheW interface [polypeptide binding]; other site
1036172000944	SdiA-regulated; Region: SdiA-regulated; pfam06977
1036172000945	SdiA-regulated; Region: SdiA-regulated; cd09971
1036172000946	putative active site [active]
1036172000947	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1036172000948	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1036172000949	active site
1036172000950	HIGH motif; other site
1036172000951	dimer interface [polypeptide binding]; other site
1036172000952	KMSKS motif; other site
1036172000953	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172000954	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172000955	N-terminal plug; other site
1036172000956	ligand-binding site [chemical binding]; other site
1036172000957	muropeptide transporter; Validated; Region: ampG; cl17669
1036172000958	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036172000959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172000960	S-adenosylmethionine binding site [chemical binding]; other site
1036172000961	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172000962	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172000963	N-terminal plug; other site
1036172000964	ligand-binding site [chemical binding]; other site
1036172000965	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036172000966	Predicted membrane protein [Function unknown]; Region: COG1971
1036172000967	Domain of unknown function DUF; Region: DUF204; pfam02659
1036172000968	Domain of unknown function DUF; Region: DUF204; pfam02659
1036172000969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172000970	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172000971	putative substrate translocation pore; other site
1036172000972	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
1036172000973	muropeptide transporter; Validated; Region: ampG; cl17669
1036172000974	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036172000975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172000976	Walker A/P-loop; other site
1036172000977	ATP binding site [chemical binding]; other site
1036172000978	Q-loop/lid; other site
1036172000979	ABC transporter signature motif; other site
1036172000980	Walker B; other site
1036172000981	D-loop; other site
1036172000982	H-loop/switch region; other site
1036172000983	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172000984	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1036172000985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172000986	Walker A/P-loop; other site
1036172000987	ATP binding site [chemical binding]; other site
1036172000988	Q-loop/lid; other site
1036172000989	ABC transporter signature motif; other site
1036172000990	Walker B; other site
1036172000991	D-loop; other site
1036172000992	H-loop/switch region; other site
1036172000993	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172000994	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172000995	N-terminal plug; other site
1036172000996	ligand-binding site [chemical binding]; other site
1036172000997	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036172000998	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1036172000999	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1036172001000	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1036172001001	putative metal binding site [ion binding]; other site
1036172001002	putative homodimer interface [polypeptide binding]; other site
1036172001003	putative homotetramer interface [polypeptide binding]; other site
1036172001004	putative homodimer-homodimer interface [polypeptide binding]; other site
1036172001005	putative allosteric switch controlling residues; other site
1036172001006	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1036172001007	seryl-tRNA synthetase; Provisional; Region: PRK05431
1036172001008	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1036172001009	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1036172001010	dimer interface [polypeptide binding]; other site
1036172001011	active site
1036172001012	motif 1; other site
1036172001013	motif 2; other site
1036172001014	motif 3; other site
1036172001015	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1036172001016	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1036172001017	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1036172001018	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
1036172001019	PAS fold; Region: PAS_4; pfam08448
1036172001020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036172001021	putative active site [active]
1036172001022	heme pocket [chemical binding]; other site
1036172001023	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172001024	metal binding site [ion binding]; metal-binding site
1036172001025	active site
1036172001026	I-site; other site
1036172001027	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172001028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001029	PAS fold; Region: PAS_3; pfam08447
1036172001030	putative active site [active]
1036172001031	heme pocket [chemical binding]; other site
1036172001032	NapD protein; Region: NapD; cl01163
1036172001033	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1036172001034	structural tetrad; other site
1036172001035	ferredoxin-type protein NapF; Region: napF; TIGR00402
1036172001036	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
1036172001037	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
1036172001038	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1036172001039	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1036172001040	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036172001041	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
1036172001042	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1036172001043	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172001044	molybdopterin cofactor binding site; other site
1036172001045	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172001046	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172001047	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1036172001048	molybdopterin cofactor binding site; other site
1036172001049	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1036172001050	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1036172001051	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1036172001052	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1036172001053	DctM-like transporters; Region: DctM; pfam06808
1036172001054	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172001055	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172001056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001057	ATP binding site [chemical binding]; other site
1036172001058	Mg2+ binding site [ion binding]; other site
1036172001059	G-X-G motif; other site
1036172001060	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172001061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001062	active site
1036172001063	phosphorylation site [posttranslational modification]
1036172001064	intermolecular recognition site; other site
1036172001065	dimerization interface [polypeptide binding]; other site
1036172001066	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172001067	DNA binding site [nucleotide binding]
1036172001068	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1036172001069	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1036172001070	diphthine synthase; Region: dph5; TIGR00522
1036172001071	active site
1036172001072	SAM binding site [chemical binding]; other site
1036172001073	homodimer interface [polypeptide binding]; other site
1036172001074	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1036172001075	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036172001076	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036172001077	ligand binding site [chemical binding]; other site
1036172001078	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
1036172001079	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036172001080	hypothetical protein; Provisional; Region: PRK07394
1036172001081	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1036172001082	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172001083	FeS/SAM binding site; other site
1036172001084	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1036172001085	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1036172001086	16S/18S rRNA binding site [nucleotide binding]; other site
1036172001087	S13e-L30e interaction site [polypeptide binding]; other site
1036172001088	25S rRNA binding site [nucleotide binding]; other site
1036172001089	Rrf2 family protein; Region: rrf2_super; TIGR00738
1036172001090	Transcriptional regulator; Region: Rrf2; pfam02082
1036172001091	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1036172001092	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1036172001093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172001094	HAMP domain; Region: HAMP; pfam00672
1036172001095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172001096	dimer interface [polypeptide binding]; other site
1036172001097	phosphorylation site [posttranslational modification]
1036172001098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001099	ATP binding site [chemical binding]; other site
1036172001100	Mg2+ binding site [ion binding]; other site
1036172001101	G-X-G motif; other site
1036172001102	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172001103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001104	active site
1036172001105	phosphorylation site [posttranslational modification]
1036172001106	intermolecular recognition site; other site
1036172001107	dimerization interface [polypeptide binding]; other site
1036172001108	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172001109	DNA binding site [nucleotide binding]
1036172001110	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1036172001111	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1036172001112	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1036172001113	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1036172001114	active site
1036172001115	intersubunit interface [polypeptide binding]; other site
1036172001116	zinc binding site [ion binding]; other site
1036172001117	Na+ binding site [ion binding]; other site
1036172001118	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1036172001119	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036172001120	NAD(P) binding site [chemical binding]; other site
1036172001121	catalytic residues [active]
1036172001122	Protein of unknown function (DUF779); Region: DUF779; cl01432
1036172001123	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1036172001124	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1036172001125	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1036172001126	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1036172001127	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1036172001128	catalytic residue [active]
1036172001129	shikimate kinase; Reviewed; Region: aroK; PRK00131
1036172001130	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1036172001131	ADP binding site [chemical binding]; other site
1036172001132	magnesium binding site [ion binding]; other site
1036172001133	putative shikimate binding site; other site
1036172001134	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1036172001135	histidinol dehydrogenase; Region: hisD; TIGR00069
1036172001136	NAD binding site [chemical binding]; other site
1036172001137	dimerization interface [polypeptide binding]; other site
1036172001138	product binding site; other site
1036172001139	substrate binding site [chemical binding]; other site
1036172001140	zinc binding site [ion binding]; other site
1036172001141	catalytic residues [active]
1036172001142	Domain of unknown function (DUF2018); Region: DUF2018; pfam09442
1036172001143	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1036172001144	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1036172001145	substrate binding pocket [chemical binding]; other site
1036172001146	chain length determination region; other site
1036172001147	substrate-Mg2+ binding site; other site
1036172001148	catalytic residues [active]
1036172001149	aspartate-rich region 1; other site
1036172001150	active site lid residues [active]
1036172001151	aspartate-rich region 2; other site
1036172001152	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1036172001153	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1036172001154	tRNA; other site
1036172001155	putative tRNA binding site [nucleotide binding]; other site
1036172001156	putative NADP binding site [chemical binding]; other site
1036172001157	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1036172001158	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1036172001159	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036172001160	motif 1; other site
1036172001161	dimer interface [polypeptide binding]; other site
1036172001162	active site
1036172001163	motif 2; other site
1036172001164	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1036172001165	putative deacylase active site [active]
1036172001166	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036172001167	active site
1036172001168	motif 3; other site
1036172001169	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1036172001170	anticodon binding site; other site
1036172001171	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1036172001172	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1036172001173	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1036172001174	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
1036172001175	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1036172001176	apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291
1036172001177	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1036172001178	active site
1036172001179	catalytic triad [active]
1036172001180	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1036172001181	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1036172001182	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1036172001183	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1036172001184	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1036172001185	Protein export membrane protein; Region: SecD_SecF; pfam02355
1036172001186	flagellar motor protein MotB; Reviewed; Region: motB; PRK08457
1036172001187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1036172001188	ligand binding site [chemical binding]; other site
1036172001189	flagellar motor protein MotA; Validated; Region: PRK08456
1036172001190	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1036172001191	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1036172001192	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1036172001193	HIGH motif; other site
1036172001194	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1036172001195	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1036172001196	active site
1036172001197	KMSKS motif; other site
1036172001198	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1036172001199	tRNA binding surface [nucleotide binding]; other site
1036172001200	Lipopolysaccharide-assembly; Region: LptE; pfam04390
1036172001201	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1036172001202	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1036172001203	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1036172001204	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172001205	ATP binding site [chemical binding]; other site
1036172001206	putative Mg++ binding site [ion binding]; other site
1036172001207	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172001208	nucleotide binding region [chemical binding]; other site
1036172001209	ATP-binding site [chemical binding]; other site
1036172001210	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1036172001211	putative acyl-acceptor binding pocket; other site
1036172001212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1036172001213	transferase, transferring glycosyl groups; Region: PLN02939
1036172001214	Dam-replacing family; Region: DRP; pfam06044
1036172001215	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1036172001216	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172001217	ATP binding site [chemical binding]; other site
1036172001218	putative Mg++ binding site [ion binding]; other site
1036172001219	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172001220	nucleotide binding region [chemical binding]; other site
1036172001221	ATP-binding site [chemical binding]; other site
1036172001222	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1036172001223	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036172001224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172001225	Coenzyme A binding pocket [chemical binding]; other site
1036172001226	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1036172001227	putative catalytic site [active]
1036172001228	putative metal binding site [ion binding]; other site
1036172001229	putative phosphate binding site [ion binding]; other site
1036172001230	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
1036172001231	dimer interface [polypeptide binding]; other site
1036172001232	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172001233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001234	active site
1036172001235	phosphorylation site [posttranslational modification]
1036172001236	intermolecular recognition site; other site
1036172001237	dimerization interface [polypeptide binding]; other site
1036172001238	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172001239	DNA binding site [nucleotide binding]
1036172001240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172001241	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036172001242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001243	ATP binding site [chemical binding]; other site
1036172001244	Mg2+ binding site [ion binding]; other site
1036172001245	G-X-G motif; other site
1036172001246	flavoprotein, HI0933 family; Region: TIGR00275
1036172001247	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172001248	dimer interface [polypeptide binding]; other site
1036172001249	putative CheW interface [polypeptide binding]; other site
1036172001250	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1036172001251	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172001252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001253	active site
1036172001254	phosphorylation site [posttranslational modification]
1036172001255	intermolecular recognition site; other site
1036172001256	dimerization interface [polypeptide binding]; other site
1036172001257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001258	PAS domain; Region: PAS_9; pfam13426
1036172001259	putative active site [active]
1036172001260	heme pocket [chemical binding]; other site
1036172001261	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172001262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001263	PAS domain; Region: PAS_9; pfam13426
1036172001264	putative active site [active]
1036172001265	heme pocket [chemical binding]; other site
1036172001266	PAS domain S-box; Region: sensory_box; TIGR00229
1036172001267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001268	putative active site [active]
1036172001269	heme pocket [chemical binding]; other site
1036172001270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172001271	dimer interface [polypeptide binding]; other site
1036172001272	phosphorylation site [posttranslational modification]
1036172001273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001274	ATP binding site [chemical binding]; other site
1036172001275	Mg2+ binding site [ion binding]; other site
1036172001276	G-X-G motif; other site
1036172001277	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1036172001278	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036172001279	putative active site [active]
1036172001280	metal binding site [ion binding]; metal-binding site
1036172001281	homodimer binding site [polypeptide binding]; other site
1036172001282	conjugal transfer protein TraL; Provisional; Region: PRK13886
1036172001283	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1036172001284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172001285	S-adenosylmethionine binding site [chemical binding]; other site
1036172001286	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1036172001287	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1036172001288	generic binding surface II; other site
1036172001289	generic binding surface I; other site
1036172001290	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1036172001291	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1036172001292	active site
1036172001293	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1036172001294	tetramerization interface [polypeptide binding]; other site
1036172001295	active site
1036172001296	hypothetical protein; Provisional; Region: PRK03762
1036172001297	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1036172001298	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1036172001299	substrate binding pocket [chemical binding]; other site
1036172001300	chain length determination region; other site
1036172001301	substrate-Mg2+ binding site; other site
1036172001302	catalytic residues [active]
1036172001303	aspartate-rich region 1; other site
1036172001304	active site lid residues [active]
1036172001305	aspartate-rich region 2; other site
1036172001306	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1036172001307	oligomerisation interface [polypeptide binding]; other site
1036172001308	mobile loop; other site
1036172001309	roof hairpin; other site
1036172001310	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1036172001311	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1036172001312	ring oligomerisation interface [polypeptide binding]; other site
1036172001313	ATP/Mg binding site [chemical binding]; other site
1036172001314	stacking interactions; other site
1036172001315	hinge regions; other site
1036172001316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036172001317	dimerization interface [polypeptide binding]; other site
1036172001318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172001319	dimer interface [polypeptide binding]; other site
1036172001320	phosphorylation site [posttranslational modification]
1036172001321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001322	ATP binding site [chemical binding]; other site
1036172001323	G-X-G motif; other site
1036172001324	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1036172001325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001326	active site
1036172001327	phosphorylation site [posttranslational modification]
1036172001328	intermolecular recognition site; other site
1036172001329	dimerization interface [polypeptide binding]; other site
1036172001330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172001331	DNA binding site [nucleotide binding]
1036172001332	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036172001333	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036172001334	putative active site [active]
1036172001335	putative metal binding site [ion binding]; other site
1036172001336	YceI-like domain; Region: YceI; pfam04264
1036172001337	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172001338	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036172001339	Walker A/P-loop; other site
1036172001340	ATP binding site [chemical binding]; other site
1036172001341	Q-loop/lid; other site
1036172001342	ABC transporter signature motif; other site
1036172001343	Walker B; other site
1036172001344	D-loop; other site
1036172001345	H-loop/switch region; other site
1036172001346	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036172001347	FtsX-like permease family; Region: FtsX; pfam02687
1036172001348	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1036172001349	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1036172001350	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1036172001351	active site
1036172001352	dimerization interface [polypeptide binding]; other site
1036172001353	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1036172001354	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1036172001355	glutaminase active site [active]
1036172001356	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1036172001357	dimer interface [polypeptide binding]; other site
1036172001358	active site
1036172001359	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1036172001360	dimer interface [polypeptide binding]; other site
1036172001361	active site
1036172001362	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1036172001363	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1036172001364	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1036172001365	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1036172001366	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1036172001367	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1036172001368	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1036172001369	thiamine phosphate binding site [chemical binding]; other site
1036172001370	active site
1036172001371	pyrophosphate binding site [ion binding]; other site
1036172001372	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1036172001373	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1036172001374	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1036172001375	FMN binding site [chemical binding]; other site
1036172001376	active site
1036172001377	catalytic residues [active]
1036172001378	substrate binding site [chemical binding]; other site
1036172001379	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1036172001380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172001381	S-adenosylmethionine binding site [chemical binding]; other site
1036172001382	FtsH Extracellular; Region: FtsH_ext; pfam06480
1036172001383	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1036172001384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172001385	Walker A motif; other site
1036172001386	ATP binding site [chemical binding]; other site
1036172001387	Walker B motif; other site
1036172001388	arginine finger; other site
1036172001389	Peptidase family M41; Region: Peptidase_M41; pfam01434
1036172001390	2-isopropylmalate synthase; Validated; Region: PRK00915
1036172001391	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1036172001392	active site
1036172001393	catalytic residues [active]
1036172001394	metal binding site [ion binding]; metal-binding site
1036172001395	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1036172001396	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036172001397	catalytic residues [active]
1036172001398	Haem-binding domain; Region: Haem_bd; pfam14376
1036172001399	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
1036172001400	MutS domain I; Region: MutS_I; pfam01624
1036172001401	MutS domain III; Region: MutS_III; pfam05192
1036172001402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172001403	Walker A/P-loop; other site
1036172001404	ATP binding site [chemical binding]; other site
1036172001405	Q-loop/lid; other site
1036172001406	ABC transporter signature motif; other site
1036172001407	Walker B; other site
1036172001408	D-loop; other site
1036172001409	H-loop/switch region; other site
1036172001410	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1036172001411	active site
1036172001412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1036172001413	Transposase; Region: HTH_Tnp_1; cl17663
1036172001414	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036172001415	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
1036172001416	Cytochrome c; Region: Cytochrom_C; pfam00034
1036172001417	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
1036172001418	Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099
1036172001419	Domain of unknown function (DUF1928); Region: DUF1928; pfam09100
1036172001420	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
1036172001421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172001422	FeS/SAM binding site; other site
1036172001423	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1036172001424	Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992
1036172001425	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
1036172001426	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036172001427	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172001428	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1036172001429	Walker A/P-loop; other site
1036172001430	ATP binding site [chemical binding]; other site
1036172001431	Q-loop/lid; other site
1036172001432	ABC transporter signature motif; other site
1036172001433	Walker B; other site
1036172001434	D-loop; other site
1036172001435	H-loop/switch region; other site
1036172001436	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1036172001437	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1036172001438	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172001439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172001440	metal binding site [ion binding]; metal-binding site
1036172001441	active site
1036172001442	I-site; other site
1036172001443	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1036172001444	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1036172001445	catalytic residues [active]
1036172001446	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1036172001447	TIGR01777 family protein; Region: yfcH
1036172001448	putative NAD(P) binding site [chemical binding]; other site
1036172001449	putative active site [active]
1036172001450	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1036172001451	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1036172001452	putative active site [active]
1036172001453	oxyanion strand; other site
1036172001454	catalytic triad [active]
1036172001455	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
1036172001456	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1036172001457	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1036172001458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172001459	active site
1036172001460	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1036172001461	GIY-YIG motif/motif A; other site
1036172001462	active site
1036172001463	catalytic site [active]
1036172001464	GTP-binding protein LepA; Provisional; Region: PRK05433
1036172001465	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1036172001466	G1 box; other site
1036172001467	putative GEF interaction site [polypeptide binding]; other site
1036172001468	GTP/Mg2+ binding site [chemical binding]; other site
1036172001469	Switch I region; other site
1036172001470	G2 box; other site
1036172001471	G3 box; other site
1036172001472	Switch II region; other site
1036172001473	G4 box; other site
1036172001474	G5 box; other site
1036172001475	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1036172001476	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1036172001477	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1036172001478	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
1036172001479	putative homodimer interface [polypeptide binding]; other site
1036172001480	putative homotetramer interface [polypeptide binding]; other site
1036172001481	putative allosteric switch controlling residues; other site
1036172001482	putative metal binding site [ion binding]; other site
1036172001483	putative homodimer-homodimer interface [polypeptide binding]; other site
1036172001484	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036172001485	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036172001486	metal-binding site [ion binding]
1036172001487	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036172001488	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036172001489	metal-binding site [ion binding]
1036172001490	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1036172001491	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172001492	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172001493	ligand binding site [chemical binding]; other site
1036172001494	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1036172001495	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1036172001496	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172001497	active site
1036172001498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1036172001499	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1036172001500	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1036172001501	Ligand Binding Site [chemical binding]; other site
1036172001502	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1036172001503	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1036172001504	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1036172001505	catalytic center binding site [active]
1036172001506	ATP binding site [chemical binding]; other site
1036172001507	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1036172001508	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1036172001509	active site
1036172001510	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1036172001511	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1036172001512	trimer interface [polypeptide binding]; other site
1036172001513	active site
1036172001514	dimer interface [polypeptide binding]; other site
1036172001515	chlorohydrolase; Provisional; Region: PRK08418
1036172001516	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1036172001517	active site
1036172001518	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1036172001519	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1036172001520	tandem repeat interface [polypeptide binding]; other site
1036172001521	oligomer interface [polypeptide binding]; other site
1036172001522	active site residues [active]
1036172001523	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1036172001524	hypothetical protein; Provisional; Region: PRK10215
1036172001525	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1036172001526	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172001527	Sel1-like repeats; Region: SEL1; smart00671
1036172001528	Sel1-like repeats; Region: SEL1; smart00671
1036172001529	Sel1-like repeats; Region: SEL1; smart00671
1036172001530	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1036172001531	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1036172001532	propionate/acetate kinase; Provisional; Region: PRK12379
1036172001533	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1036172001534	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1036172001535	propionate/acetate kinase; Provisional; Region: PRK12379
1036172001536	Cation efflux family; Region: Cation_efflux; cl00316
1036172001537	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1036172001538	propionate/acetate kinase; Provisional; Region: PRK12379
1036172001539	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036172001540	active site
1036172001541	catalytic site [active]
1036172001542	substrate binding site [chemical binding]; other site
1036172001543	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1036172001544	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036172001545	ligand binding site [chemical binding]; other site
1036172001546	flexible hinge region; other site
1036172001547	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1036172001548	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1036172001549	metal binding triad; other site
1036172001550	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1036172001551	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1036172001552	Na binding site [ion binding]; other site
1036172001553	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1036172001554	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1036172001555	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1036172001556	Na binding site [ion binding]; other site
1036172001557	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1036172001558	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1036172001559	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036172001560	active site
1036172001561	catalytic site [active]
1036172001562	substrate binding site [chemical binding]; other site
1036172001563	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1036172001564	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036172001565	ligand binding site [chemical binding]; other site
1036172001566	flexible hinge region; other site
1036172001567	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1036172001568	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1036172001569	metal binding triad; other site
1036172001570	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1036172001571	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1036172001572	Na binding site [ion binding]; other site
1036172001573	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
1036172001574	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172001575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001576	active site
1036172001577	phosphorylation site [posttranslational modification]
1036172001578	intermolecular recognition site; other site
1036172001579	dimerization interface [polypeptide binding]; other site
1036172001580	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172001581	DNA binding site [nucleotide binding]
1036172001582	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172001583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172001584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172001585	dimer interface [polypeptide binding]; other site
1036172001586	phosphorylation site [posttranslational modification]
1036172001587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172001588	ATP binding site [chemical binding]; other site
1036172001589	Mg2+ binding site [ion binding]; other site
1036172001590	G-X-G motif; other site
1036172001591	Competence-damaged protein; Region: CinA; pfam02464
1036172001592	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1036172001593	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1036172001594	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1036172001595	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036172001596	active site
1036172001597	HIGH motif; other site
1036172001598	nucleotide binding site [chemical binding]; other site
1036172001599	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1036172001600	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1036172001601	active site
1036172001602	KMSKS motif; other site
1036172001603	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1036172001604	tRNA binding surface [nucleotide binding]; other site
1036172001605	anticodon binding site; other site
1036172001606	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1036172001607	NifU-like domain; Region: NifU; cl00484
1036172001608	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1036172001609	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036172001610	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036172001611	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
1036172001612	gating phenylalanine in ion channel; other site
1036172001613	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036172001614	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036172001615	active site
1036172001616	catalytic tetrad [active]
1036172001617	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1036172001618	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1036172001619	HAMP domain; Region: HAMP; pfam00672
1036172001620	dimerization interface [polypeptide binding]; other site
1036172001621	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172001622	dimer interface [polypeptide binding]; other site
1036172001623	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172001624	putative CheW interface [polypeptide binding]; other site
1036172001625	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1036172001626	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172001627	dimer interface [polypeptide binding]; other site
1036172001628	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172001629	putative CheW interface [polypeptide binding]; other site
1036172001630	TIR domain; Region: TIR_2; pfam13676
1036172001631	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1036172001632	active site
1036172001633	nuclease NucT; Provisional; Region: PRK13912
1036172001634	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
1036172001635	putative active site [active]
1036172001636	catalytic site [active]
1036172001637	Peptidase family M48; Region: Peptidase_M48; pfam01435
1036172001638	RmuC family; Region: RmuC; pfam02646
1036172001639	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036172001640	EamA-like transporter family; Region: EamA; pfam00892
1036172001641	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1036172001642	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1036172001643	dimer interface [polypeptide binding]; other site
1036172001644	putative functional site; other site
1036172001645	putative MPT binding site; other site
1036172001646	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1036172001647	Ligand Binding Site [chemical binding]; other site
1036172001648	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1036172001649	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1036172001650	SprA-related family; Region: SprA-related; pfam12118
1036172001651	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1036172001652	rRNA interaction site [nucleotide binding]; other site
1036172001653	S8 interaction site; other site
1036172001654	putative laminin-1 binding site; other site
1036172001655	elongation factor Ts; Provisional; Region: tsf; PRK09377
1036172001656	UBA/TS-N domain; Region: UBA; pfam00627
1036172001657	Elongation factor TS; Region: EF_TS; pfam00889
1036172001658	Elongation factor TS; Region: EF_TS; pfam00889
1036172001659	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172001660	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036172001661	Walker A/P-loop; other site
1036172001662	ATP binding site [chemical binding]; other site
1036172001663	Q-loop/lid; other site
1036172001664	ABC transporter signature motif; other site
1036172001665	Walker B; other site
1036172001666	D-loop; other site
1036172001667	H-loop/switch region; other site
1036172001668	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1036172001669	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1036172001670	catalytic site [active]
1036172001671	G-X2-G-X-G-K; other site
1036172001672	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172001673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001674	active site
1036172001675	phosphorylation site [posttranslational modification]
1036172001676	intermolecular recognition site; other site
1036172001677	dimerization interface [polypeptide binding]; other site
1036172001678	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172001679	metal binding site [ion binding]; metal-binding site
1036172001680	active site
1036172001681	I-site; other site
1036172001682	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172001683	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1036172001684	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036172001685	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036172001686	metal-binding site [ion binding]
1036172001687	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036172001688	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172001689	motif II; other site
1036172001690	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
1036172001691	Cytochrome c; Region: Cytochrom_C; cl11414
1036172001692	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172001693	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036172001694	Walker A/P-loop; other site
1036172001695	ATP binding site [chemical binding]; other site
1036172001696	Q-loop/lid; other site
1036172001697	ABC transporter signature motif; other site
1036172001698	Walker B; other site
1036172001699	D-loop; other site
1036172001700	H-loop/switch region; other site
1036172001701	ferrochelatase; Reviewed; Region: hemH; PRK00035
1036172001702	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1036172001703	C-terminal domain interface [polypeptide binding]; other site
1036172001704	active site
1036172001705	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1036172001706	active site
1036172001707	N-terminal domain interface [polypeptide binding]; other site
1036172001708	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1036172001709	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1036172001710	G1 box; other site
1036172001711	GTP/Mg2+ binding site [chemical binding]; other site
1036172001712	Switch I region; other site
1036172001713	G2 box; other site
1036172001714	G3 box; other site
1036172001715	Switch II region; other site
1036172001716	G4 box; other site
1036172001717	G5 box; other site
1036172001718	Nucleoside recognition; Region: Gate; pfam07670
1036172001719	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1036172001720	Nucleoside recognition; Region: Gate; pfam07670
1036172001721	FeoA domain; Region: FeoA; pfam04023
1036172001722	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1036172001723	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1036172001724	putative active site [active]
1036172001725	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172001726	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1036172001727	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1036172001728	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036172001729	dimer interface [polypeptide binding]; other site
1036172001730	putative PBP binding regions; other site
1036172001731	ABC-ATPase subunit  interface; other site
1036172001732	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1036172001733	S1 domain; Region: S1_2; pfam13509
1036172001734	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036172001735	RNA binding site [nucleotide binding]; other site
1036172001736	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1036172001737	dimer interface [polypeptide binding]; other site
1036172001738	catalytic triad [active]
1036172001739	peroxidatic and resolving cysteines [active]
1036172001740	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172001741	Sel1-like repeats; Region: SEL1; smart00671
1036172001742	Sel1 repeat; Region: Sel1; cl02723
1036172001743	Sel1-like repeats; Region: SEL1; smart00671
1036172001744	Sel1-like repeats; Region: SEL1; smart00671
1036172001745	Sel1-like repeats; Region: SEL1; smart00671
1036172001746	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1036172001747	NnrS protein; Region: NnrS; pfam05940
1036172001748	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1036172001749	Part of AAA domain; Region: AAA_19; pfam13245
1036172001750	Family description; Region: UvrD_C_2; pfam13538
1036172001751	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1036172001752	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1036172001753	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1036172001754	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036172001755	active site
1036172001756	HIGH motif; other site
1036172001757	nucleotide binding site [chemical binding]; other site
1036172001758	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1036172001759	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1036172001760	active site
1036172001761	KMSKS motif; other site
1036172001762	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1036172001763	tRNA binding surface [nucleotide binding]; other site
1036172001764	anticodon binding site; other site
1036172001765	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1036172001766	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1036172001767	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1036172001768	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1036172001769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172001770	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172001771	putative substrate translocation pore; other site
1036172001772	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1036172001773	active site
1036172001774	dimerization interface [polypeptide binding]; other site
1036172001775	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1036172001776	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1036172001777	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
1036172001778	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1036172001779	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
1036172001780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172001781	Walker A motif; other site
1036172001782	ATP binding site [chemical binding]; other site
1036172001783	Walker B motif; other site
1036172001784	arginine finger; other site
1036172001785	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1036172001786	Rhomboid family; Region: Rhomboid; pfam01694
1036172001787	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1036172001788	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1036172001789	active site
1036172001790	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036172001791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001792	putative active site [active]
1036172001793	heme pocket [chemical binding]; other site
1036172001794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172001795	putative active site [active]
1036172001796	heme pocket [chemical binding]; other site
1036172001797	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172001798	dimer interface [polypeptide binding]; other site
1036172001799	putative CheW interface [polypeptide binding]; other site
1036172001800	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
1036172001801	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036172001802	EamA-like transporter family; Region: EamA; pfam00892
1036172001803	YceI-like domain; Region: YceI; cl01001
1036172001804	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1036172001805	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172001806	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1036172001807	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1036172001808	Domain of unknown function DUF59; Region: DUF59; cl00941
1036172001809	Fe-S metabolism associated domain; Region: SufE; cl00951
1036172001810	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1036172001811	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1036172001812	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172001813	catalytic residue [active]
1036172001814	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1036172001815	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1036172001816	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1036172001817	FeS assembly ATPase SufC; Region: sufC; TIGR01978
1036172001818	Walker A/P-loop; other site
1036172001819	ATP binding site [chemical binding]; other site
1036172001820	Q-loop/lid; other site
1036172001821	ABC transporter signature motif; other site
1036172001822	Walker B; other site
1036172001823	D-loop; other site
1036172001824	H-loop/switch region; other site
1036172001825	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1036172001826	putative ABC transporter; Region: ycf24; CHL00085
1036172001827	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036172001828	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1036172001829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172001830	catalytic residue [active]
1036172001831	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
1036172001832	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1036172001833	trimerization site [polypeptide binding]; other site
1036172001834	active site
1036172001835	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036172001836	NifU-like domain; Region: NifU; cl00484
1036172001837	FOG: CBS domain [General function prediction only]; Region: COG0517
1036172001838	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1036172001839	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172001840	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172001841	metal binding site [ion binding]; metal-binding site
1036172001842	active site
1036172001843	I-site; other site
1036172001844	argininosuccinate lyase; Provisional; Region: PRK00855
1036172001845	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1036172001846	active sites [active]
1036172001847	tetramer interface [polypeptide binding]; other site
1036172001848	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1036172001849	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172001850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172001851	active site
1036172001852	phosphorylation site [posttranslational modification]
1036172001853	intermolecular recognition site; other site
1036172001854	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1036172001855	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1036172001856	putative ATP binding site [chemical binding]; other site
1036172001857	putative substrate interface [chemical binding]; other site
1036172001858	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1036172001859	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1036172001860	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1036172001861	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1036172001862	putative active site [active]
1036172001863	putative metal binding site [ion binding]; other site
1036172001864	excinuclease ABC subunit B; Provisional; Region: PRK05298
1036172001865	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172001866	ATP binding site [chemical binding]; other site
1036172001867	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172001868	nucleotide binding region [chemical binding]; other site
1036172001869	ATP-binding site [chemical binding]; other site
1036172001870	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1036172001871	UvrB/uvrC motif; Region: UVR; pfam02151
1036172001872	AAA domain; Region: AAA_21; pfam13304
1036172001873	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172001874	Walker B; other site
1036172001875	D-loop; other site
1036172001876	H-loop/switch region; other site
1036172001877	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172001878	MULE transposase domain; Region: MULE; pfam10551
1036172001879	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1036172001880	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1036172001881	minor groove reading motif; other site
1036172001882	helix-hairpin-helix signature motif; other site
1036172001883	substrate binding pocket [chemical binding]; other site
1036172001884	active site
1036172001885	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172001886	N-terminal plug; other site
1036172001887	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
1036172001888	ligand-binding site [chemical binding]; other site
1036172001889	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
1036172001890	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172001891	N-terminal plug; other site
1036172001892	ligand-binding site [chemical binding]; other site
1036172001893	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172001894	MULE transposase domain; Region: MULE; pfam10551
1036172001895	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172001896	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172001897	dimer interface [polypeptide binding]; other site
1036172001898	putative CheW interface [polypeptide binding]; other site
1036172001899	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
1036172001900	active site
1036172001901	GIY-YIG motif/motif A; other site
1036172001902	catalytic site [active]
1036172001903	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1036172001904	HD domain; Region: HD_3; pfam13023
1036172001905	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1036172001906	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1036172001907	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036172001908	Catalytic site [active]
1036172001909	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036172001910	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191
1036172001911	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1036172001912	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1036172001913	homodimer interface [polypeptide binding]; other site
1036172001914	NADP binding site [chemical binding]; other site
1036172001915	substrate binding site [chemical binding]; other site
1036172001916	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1036172001917	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1036172001918	5S rRNA interface [nucleotide binding]; other site
1036172001919	CTC domain interface [polypeptide binding]; other site
1036172001920	L16 interface [polypeptide binding]; other site
1036172001921	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1036172001922	putative active site [active]
1036172001923	catalytic residue [active]
1036172001924	Predicted permeases [General function prediction only]; Region: COG0795
1036172001925	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1036172001926	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036172001927	nudix motif; other site
1036172001928	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036172001929	nudix motif; other site
1036172001930	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1036172001931	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1036172001932	active site
1036172001933	metal binding site [ion binding]; metal-binding site
1036172001934	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1036172001935	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1036172001936	FMN binding site [chemical binding]; other site
1036172001937	substrate binding site [chemical binding]; other site
1036172001938	putative catalytic residue [active]
1036172001939	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1036172001940	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1036172001941	active site
1036172001942	HIGH motif; other site
1036172001943	dimer interface [polypeptide binding]; other site
1036172001944	KMSKS motif; other site
1036172001945	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172001946	RNA binding surface [nucleotide binding]; other site
1036172001947	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1036172001948	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036172001949	Zn2+ binding site [ion binding]; other site
1036172001950	Mg2+ binding site [ion binding]; other site
1036172001951	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1036172001952	synthetase active site [active]
1036172001953	NTP binding site [chemical binding]; other site
1036172001954	metal binding site [ion binding]; metal-binding site
1036172001955	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1036172001956	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1036172001957	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1036172001958	putative nucleotide binding site [chemical binding]; other site
1036172001959	uridine monophosphate binding site [chemical binding]; other site
1036172001960	homohexameric interface [polypeptide binding]; other site
1036172001961	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1036172001962	AAA domain; Region: AAA_14; pfam13173
1036172001963	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946
1036172001964	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1036172001965	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
1036172001966	active site
1036172001967	hydrophilic channel; other site
1036172001968	dimerization interface [polypeptide binding]; other site
1036172001969	catalytic residues [active]
1036172001970	active site lid [active]
1036172001971	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1036172001972	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1036172001973	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1036172001974	Sporulation related domain; Region: SPOR; pfam05036
1036172001975	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1036172001976	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1036172001977	dimer interface [polypeptide binding]; other site
1036172001978	active site
1036172001979	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1036172001980	folate binding site [chemical binding]; other site
1036172001981	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1036172001982	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1036172001983	dimer interface [polypeptide binding]; other site
1036172001984	putative anticodon binding site; other site
1036172001985	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1036172001986	motif 1; other site
1036172001987	active site
1036172001988	motif 2; other site
1036172001989	motif 3; other site
1036172001990	Colicin V production protein; Region: Colicin_V; pfam02674
1036172001991	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1036172001992	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1036172001993	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1036172001994	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1036172001995	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172001996	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172001997	metal binding site [ion binding]; metal-binding site
1036172001998	active site
1036172001999	I-site; other site
1036172002000	replicative DNA helicase; Provisional; Region: PRK08506
1036172002001	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1036172002002	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1036172002003	Walker A motif; other site
1036172002004	ATP binding site [chemical binding]; other site
1036172002005	Walker B motif; other site
1036172002006	DNA binding loops [nucleotide binding]
1036172002007	Chain length determinant protein; Region: Wzz; cl15801
1036172002008	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1036172002009	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1036172002010	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1036172002011	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1036172002012	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1036172002013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036172002014	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1036172002015	putative NAD(P) binding site [chemical binding]; other site
1036172002016	active site
1036172002017	putative substrate binding site [chemical binding]; other site
1036172002018	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1036172002019	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1036172002020	substrate binding site; other site
1036172002021	tetramer interface; other site
1036172002022	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1036172002023	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1036172002024	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1036172002025	NADP binding site [chemical binding]; other site
1036172002026	active site
1036172002027	putative substrate binding site [chemical binding]; other site
1036172002028	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1036172002029	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1036172002030	NAD binding site [chemical binding]; other site
1036172002031	substrate binding site [chemical binding]; other site
1036172002032	homodimer interface [polypeptide binding]; other site
1036172002033	active site
1036172002034	Domain of unknown function (DUF386); Region: DUF386; cl01047
1036172002035	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036172002036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172002037	S-adenosylmethionine binding site [chemical binding]; other site
1036172002038	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036172002039	active site
1036172002040	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1036172002041	active site
1036172002042	catalytic residues [active]
1036172002043	metal binding site [ion binding]; metal-binding site
1036172002044	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1036172002045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172002046	active site
1036172002047	motif I; other site
1036172002048	motif II; other site
1036172002049	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1036172002050	active site
1036172002051	substrate binding site [chemical binding]; other site
1036172002052	trimer interface [polypeptide binding]; other site
1036172002053	CoA binding site [chemical binding]; other site
1036172002054	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
1036172002055	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1036172002056	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036172002057	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036172002058	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1036172002059	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1036172002060	Probable Catalytic site; other site
1036172002061	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036172002062	active site
1036172002063	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036172002064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036172002065	NAD(P) binding site [chemical binding]; other site
1036172002066	active site
1036172002067	PemK-like protein; Region: PemK; pfam02452
1036172002068	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1036172002069	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1036172002070	Mg++ binding site [ion binding]; other site
1036172002071	putative catalytic motif [active]
1036172002072	putative substrate binding site [chemical binding]; other site
1036172002073	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1036172002074	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1036172002075	NAD(P) binding site [chemical binding]; other site
1036172002076	homodimer interface [polypeptide binding]; other site
1036172002077	substrate binding site [chemical binding]; other site
1036172002078	active site
1036172002079	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1036172002080	DNA ligase; Provisional; Region: PRK09125
1036172002081	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
1036172002082	DNA binding site [nucleotide binding]
1036172002083	active site
1036172002084	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
1036172002085	DNA binding site [nucleotide binding]
1036172002086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172002087	active site
1036172002088	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1036172002089	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1036172002090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172002091	catalytic residue [active]
1036172002092	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036172002093	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036172002094	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1036172002095	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1036172002096	interface (dimer of trimers) [polypeptide binding]; other site
1036172002097	Substrate-binding/catalytic site; other site
1036172002098	Zn-binding sites [ion binding]; other site
1036172002099	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1036172002100	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1036172002101	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1036172002102	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
1036172002103	Outer membrane efflux protein; Region: OEP; pfam02321
1036172002104	Outer membrane efflux protein; Region: OEP; pfam02321
1036172002105	HlyD family secretion protein; Region: HlyD_2; pfam12700
1036172002106	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036172002107	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172002108	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172002109	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036172002110	Walker A/P-loop; other site
1036172002111	ATP binding site [chemical binding]; other site
1036172002112	Q-loop/lid; other site
1036172002113	ABC transporter signature motif; other site
1036172002114	Walker B; other site
1036172002115	D-loop; other site
1036172002116	H-loop/switch region; other site
1036172002117	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036172002118	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036172002119	FtsX-like permease family; Region: FtsX; pfam02687
1036172002120	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172002121	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172002122	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1036172002123	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036172002124	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172002125	active site
1036172002126	motif I; other site
1036172002127	motif II; other site
1036172002128	YtxH-like protein; Region: YtxH; cl02079
1036172002129	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
1036172002130	diiron binding motif [ion binding]; other site
1036172002131	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036172002132	metal binding site 2 [ion binding]; metal-binding site
1036172002133	putative DNA binding helix; other site
1036172002134	metal binding site 1 [ion binding]; metal-binding site
1036172002135	dimer interface [polypeptide binding]; other site
1036172002136	structural Zn2+ binding site [ion binding]; other site
1036172002137	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1036172002138	Class II fumarases; Region: Fumarase_classII; cd01362
1036172002139	active site
1036172002140	tetramer interface [polypeptide binding]; other site
1036172002141	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172002142	MULE transposase domain; Region: MULE; pfam10551
1036172002143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1036172002144	Histidine kinase; Region: HisKA_2; pfam07568
1036172002145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172002146	ATP binding site [chemical binding]; other site
1036172002147	Mg2+ binding site [ion binding]; other site
1036172002148	G-X-G motif; other site
1036172002149	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172002150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002151	active site
1036172002152	phosphorylation site [posttranslational modification]
1036172002153	intermolecular recognition site; other site
1036172002154	dimerization interface [polypeptide binding]; other site
1036172002155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1036172002156	DNA binding site [nucleotide binding]
1036172002157	putative outer membrane receptor; Provisional; Region: PRK13513
1036172002158	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172002159	N-terminal plug; other site
1036172002160	ligand-binding site [chemical binding]; other site
1036172002161	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1036172002162	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036172002163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172002164	S-adenosylmethionine binding site [chemical binding]; other site
1036172002165	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
1036172002166	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1036172002167	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1036172002168	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1036172002169	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1036172002170	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1036172002171	carbon starvation protein A; Provisional; Region: PRK15015
1036172002172	Carbon starvation protein CstA; Region: CstA; pfam02554
1036172002173	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1036172002174	GTP-binding protein YchF; Reviewed; Region: PRK09601
1036172002175	YchF GTPase; Region: YchF; cd01900
1036172002176	G1 box; other site
1036172002177	GTP/Mg2+ binding site [chemical binding]; other site
1036172002178	Switch I region; other site
1036172002179	G2 box; other site
1036172002180	Switch II region; other site
1036172002181	G3 box; other site
1036172002182	G4 box; other site
1036172002183	G5 box; other site
1036172002184	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1036172002185	HDOD domain; Region: HDOD; pfam08668
1036172002186	putative recombination protein RecO; Provisional; Region: PRK13908
1036172002187	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1036172002188	NosL; Region: NosL; cl01769
1036172002189	thiamine monophosphate kinase; Provisional; Region: PRK05731
1036172002190	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1036172002191	ATP binding site [chemical binding]; other site
1036172002192	dimerization interface [polypeptide binding]; other site
1036172002193	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1036172002194	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1036172002195	Permutation of conserved domain; other site
1036172002196	active site
1036172002197	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1036172002198	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002199	dimer interface [polypeptide binding]; other site
1036172002200	putative CheW interface [polypeptide binding]; other site
1036172002201	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1036172002202	RuvA N terminal domain; Region: RuvA_N; pfam01330
1036172002203	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1036172002204	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1036172002205	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172002206	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036172002207	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1036172002208	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036172002209	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1036172002210	nucleotide binding site/active site [active]
1036172002211	HIT family signature motif; other site
1036172002212	catalytic residue [active]
1036172002213	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1036172002214	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1036172002215	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1036172002216	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1036172002217	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1036172002218	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1036172002219	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1036172002220	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1036172002221	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1036172002222	putative translocon binding site; other site
1036172002223	protein-rRNA interface [nucleotide binding]; other site
1036172002224	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1036172002225	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1036172002226	G-X-X-G motif; other site
1036172002227	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1036172002228	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1036172002229	23S rRNA interface [nucleotide binding]; other site
1036172002230	5S rRNA interface [nucleotide binding]; other site
1036172002231	putative antibiotic binding site [chemical binding]; other site
1036172002232	L25 interface [polypeptide binding]; other site
1036172002233	L27 interface [polypeptide binding]; other site
1036172002234	50S ribosomal protein L29; Reviewed; Region: PRK00306
1036172002235	trigger factor interaction site; other site
1036172002236	23S rRNA interface [nucleotide binding]; other site
1036172002237	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1036172002238	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1036172002239	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1036172002240	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1036172002241	RNA binding site [nucleotide binding]; other site
1036172002242	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1036172002243	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1036172002244	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1036172002245	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1036172002246	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1036172002247	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1036172002248	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1036172002249	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1036172002250	5S rRNA interface [nucleotide binding]; other site
1036172002251	L27 interface [polypeptide binding]; other site
1036172002252	23S rRNA interface [nucleotide binding]; other site
1036172002253	L5 interface [polypeptide binding]; other site
1036172002254	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1036172002255	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1036172002256	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1036172002257	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1036172002258	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1036172002259	SecY translocase; Region: SecY; pfam00344
1036172002260	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1036172002261	active site
1036172002262	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1036172002263	rRNA binding site [nucleotide binding]; other site
1036172002264	predicted 30S ribosome binding site; other site
1036172002265	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1036172002266	Fe-S cluster binding site [ion binding]; other site
1036172002267	active site
1036172002268	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1036172002269	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1036172002270	dimer interface [polypeptide binding]; other site
1036172002271	anticodon binding site; other site
1036172002272	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1036172002273	homodimer interface [polypeptide binding]; other site
1036172002274	motif 1; other site
1036172002275	active site
1036172002276	motif 2; other site
1036172002277	GAD domain; Region: GAD; pfam02938
1036172002278	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036172002279	active site
1036172002280	motif 3; other site
1036172002281	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1036172002282	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
1036172002283	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1036172002284	adenylate kinase; Reviewed; Region: adk; PRK00279
1036172002285	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1036172002286	AMP-binding site [chemical binding]; other site
1036172002287	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1036172002288	adenylate kinase; Reviewed; Region: adk; PRK00279
1036172002289	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1036172002290	AMP-binding site [chemical binding]; other site
1036172002291	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1036172002292	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1036172002293	competence damage-inducible protein A; Provisional; Region: PRK01215
1036172002294	MPT binding site; other site
1036172002295	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1036172002296	Chloramphenicol acetyltransferase; Region: CAT; smart01059
1036172002297	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036172002298	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172002299	Coenzyme A binding pocket [chemical binding]; other site
1036172002300	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1036172002301	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1036172002302	putative NAD(P) binding site [chemical binding]; other site
1036172002303	putative substrate binding site [chemical binding]; other site
1036172002304	catalytic Zn binding site [ion binding]; other site
1036172002305	structural Zn binding site [ion binding]; other site
1036172002306	dimer interface [polypeptide binding]; other site
1036172002307	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1036172002308	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1036172002309	dimer interface [polypeptide binding]; other site
1036172002310	active site
1036172002311	metal binding site [ion binding]; metal-binding site
1036172002312	Cache domain; Region: Cache_1; pfam02743
1036172002313	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172002314	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002315	dimer interface [polypeptide binding]; other site
1036172002316	putative CheW interface [polypeptide binding]; other site
1036172002317	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1036172002318	alanine racemase; Reviewed; Region: alr; PRK00053
1036172002319	active site
1036172002320	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036172002321	dimer interface [polypeptide binding]; other site
1036172002322	substrate binding site [chemical binding]; other site
1036172002323	catalytic residues [active]
1036172002324	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1036172002325	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1036172002326	GIY-YIG motif/motif A; other site
1036172002327	active site
1036172002328	catalytic site [active]
1036172002329	putative DNA binding site [nucleotide binding]; other site
1036172002330	metal binding site [ion binding]; metal-binding site
1036172002331	UvrB/uvrC motif; Region: UVR; pfam02151
1036172002332	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1036172002333	Cache domain; Region: Cache_1; pfam02743
1036172002334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002335	dimer interface [polypeptide binding]; other site
1036172002336	putative CheW interface [polypeptide binding]; other site
1036172002337	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036172002338	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002339	dimer interface [polypeptide binding]; other site
1036172002340	putative CheW interface [polypeptide binding]; other site
1036172002341	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172002342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002343	active site
1036172002344	phosphorylation site [posttranslational modification]
1036172002345	intermolecular recognition site; other site
1036172002346	dimerization interface [polypeptide binding]; other site
1036172002347	DNA binding site [nucleotide binding]
1036172002348	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1036172002349	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172002350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002351	active site
1036172002352	phosphorylation site [posttranslational modification]
1036172002353	intermolecular recognition site; other site
1036172002354	dimerization interface [polypeptide binding]; other site
1036172002355	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172002356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172002357	dimer interface [polypeptide binding]; other site
1036172002358	phosphorylation site [posttranslational modification]
1036172002359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172002360	ATP binding site [chemical binding]; other site
1036172002361	Mg2+ binding site [ion binding]; other site
1036172002362	G-X-G motif; other site
1036172002363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172002364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172002365	dimer interface [polypeptide binding]; other site
1036172002366	phosphorylation site [posttranslational modification]
1036172002367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172002368	ATP binding site [chemical binding]; other site
1036172002369	Mg2+ binding site [ion binding]; other site
1036172002370	G-X-G motif; other site
1036172002371	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172002372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002373	active site
1036172002374	phosphorylation site [posttranslational modification]
1036172002375	intermolecular recognition site; other site
1036172002376	dimerization interface [polypeptide binding]; other site
1036172002377	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1036172002378	nudix motif; other site
1036172002379	ORF6N domain; Region: ORF6N; pfam10543
1036172002380	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1036172002381	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1036172002382	putative ligand binding site [chemical binding]; other site
1036172002383	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036172002384	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1036172002385	TM-ABC transporter signature motif; other site
1036172002386	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1036172002387	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036172002388	TM-ABC transporter signature motif; other site
1036172002389	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1036172002390	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1036172002391	Walker A/P-loop; other site
1036172002392	ATP binding site [chemical binding]; other site
1036172002393	Q-loop/lid; other site
1036172002394	ABC transporter signature motif; other site
1036172002395	Walker B; other site
1036172002396	D-loop; other site
1036172002397	H-loop/switch region; other site
1036172002398	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1036172002399	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1036172002400	Walker A/P-loop; other site
1036172002401	ATP binding site [chemical binding]; other site
1036172002402	Q-loop/lid; other site
1036172002403	ABC transporter signature motif; other site
1036172002404	Walker B; other site
1036172002405	D-loop; other site
1036172002406	H-loop/switch region; other site
1036172002407	UreD urease accessory protein; Region: UreD; cl00530
1036172002408	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
1036172002409	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1036172002410	alpha-gamma subunit interface [polypeptide binding]; other site
1036172002411	beta-gamma subunit interface [polypeptide binding]; other site
1036172002412	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1036172002413	gamma-beta subunit interface [polypeptide binding]; other site
1036172002414	alpha-beta subunit interface [polypeptide binding]; other site
1036172002415	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1036172002416	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1036172002417	subunit interactions [polypeptide binding]; other site
1036172002418	active site
1036172002419	flap region; other site
1036172002420	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
1036172002421	UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194
1036172002422	dimer interface [polypeptide binding]; other site
1036172002423	catalytic residues [active]
1036172002424	UreF; Region: UreF; pfam01730
1036172002425	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1036172002426	G1 box; other site
1036172002427	GTP/Mg2+ binding site [chemical binding]; other site
1036172002428	G2 box; other site
1036172002429	Switch I region; other site
1036172002430	G3 box; other site
1036172002431	Switch II region; other site
1036172002432	G4 box; other site
1036172002433	G5 box; other site
1036172002434	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1036172002435	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036172002436	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036172002437	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172002438	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1036172002439	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036172002440	MarR family; Region: MarR_2; cl17246
1036172002441	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1036172002442	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1036172002443	putative catalytic site [active]
1036172002444	putative metal binding site [ion binding]; other site
1036172002445	putative phosphate binding site [ion binding]; other site
1036172002446	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036172002447	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
1036172002448	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
1036172002449	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1036172002450	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1036172002451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172002452	FeS/SAM binding site; other site
1036172002453	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
1036172002454	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1036172002455	ABC1 family; Region: ABC1; cl17513
1036172002456	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1036172002457	substrate binding site [chemical binding]; other site
1036172002458	activation loop (A-loop); other site
1036172002459	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172002460	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1036172002461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002462	active site
1036172002463	phosphorylation site [posttranslational modification]
1036172002464	intermolecular recognition site; other site
1036172002465	dimerization interface [polypeptide binding]; other site
1036172002466	LytTr DNA-binding domain; Region: LytTR; smart00850
1036172002467	Histidine kinase; Region: His_kinase; pfam06580
1036172002468	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036172002469	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1036172002470	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1036172002471	DNA photolyase; Region: DNA_photolyase; pfam00875
1036172002472	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1036172002473	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1036172002474	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1036172002475	Predicted permeases [General function prediction only]; Region: COG0679
1036172002476	Domain of unknown function (DUF386); Region: DUF386; cl01047
1036172002477	glucose-6-phosphate isomerase; Provisional; Region: PRK03868
1036172002478	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1036172002479	active site
1036172002480	dimer interface [polypeptide binding]; other site
1036172002481	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1036172002482	dimer interface [polypeptide binding]; other site
1036172002483	active site
1036172002484	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1036172002485	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036172002486	active site
1036172002487	tetramer interface; other site
1036172002488	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1036172002489	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1036172002490	active site
1036172002491	substrate binding site [chemical binding]; other site
1036172002492	metal binding site [ion binding]; metal-binding site
1036172002493	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172002494	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002495	dimer interface [polypeptide binding]; other site
1036172002496	putative CheW interface [polypeptide binding]; other site
1036172002497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172002498	PAS domain; Region: PAS_9; pfam13426
1036172002499	putative active site [active]
1036172002500	heme pocket [chemical binding]; other site
1036172002501	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1036172002502	active site 1 [active]
1036172002503	dimer interface [polypeptide binding]; other site
1036172002504	hexamer interface [polypeptide binding]; other site
1036172002505	active site 2 [active]
1036172002506	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036172002507	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036172002508	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1036172002509	dimerization interface [polypeptide binding]; other site
1036172002510	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1036172002511	active site
1036172002512	ribulose/triose binding site [chemical binding]; other site
1036172002513	phosphate binding site [ion binding]; other site
1036172002514	substrate (anthranilate) binding pocket [chemical binding]; other site
1036172002515	product (indole) binding pocket [chemical binding]; other site
1036172002516	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1036172002517	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1036172002518	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1036172002519	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
1036172002520	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036172002521	2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627
1036172002522	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1036172002523	dimer interface [polypeptide binding]; other site
1036172002524	PYR/PP interface [polypeptide binding]; other site
1036172002525	TPP binding site [chemical binding]; other site
1036172002526	substrate binding site [chemical binding]; other site
1036172002527	2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628
1036172002528	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1036172002529	TPP-binding site [chemical binding]; other site
1036172002530	2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441
1036172002531	DNA polymerase III subunit epsilon; Provisional; Region: PRK08517
1036172002532	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036172002533	active site
1036172002534	catalytic site [active]
1036172002535	substrate binding site [chemical binding]; other site
1036172002536	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1036172002537	active site
1036172002538	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1036172002539	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1036172002540	substrate binding site [chemical binding]; other site
1036172002541	hexamer interface [polypeptide binding]; other site
1036172002542	metal binding site [ion binding]; metal-binding site
1036172002543	Phospholipase A1; Region: PLA1; pfam02253
1036172002544	dimerization interface [polypeptide binding]; other site
1036172002545	substrate binding site [chemical binding]; other site
1036172002546	active site
1036172002547	calcium binding site [ion binding]; other site
1036172002548	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1036172002549	dimer interface [polypeptide binding]; other site
1036172002550	ADP-ribose binding site [chemical binding]; other site
1036172002551	active site
1036172002552	nudix motif; other site
1036172002553	metal binding site [ion binding]; metal-binding site
1036172002554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1036172002555	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1036172002556	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036172002557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036172002558	NAD(P) binding site [chemical binding]; other site
1036172002559	active site
1036172002560	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1036172002561	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172002562	active site
1036172002563	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1036172002564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036172002565	catalytic residue [active]
1036172002566	Domain of unknown function (DUF932); Region: DUF932; cl12129
1036172002567	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
1036172002568	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
1036172002569	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1036172002570	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1036172002571	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
1036172002572	Fic family protein [Function unknown]; Region: COG3177
1036172002573	Fic/DOC family; Region: Fic; pfam02661
1036172002574	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1036172002575	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1036172002576	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172002577	ATP binding site [chemical binding]; other site
1036172002578	putative Mg++ binding site [ion binding]; other site
1036172002579	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1036172002580	nucleotide binding region [chemical binding]; other site
1036172002581	ATP-binding site [chemical binding]; other site
1036172002582	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036172002583	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036172002584	non-specific DNA binding site [nucleotide binding]; other site
1036172002585	salt bridge; other site
1036172002586	sequence-specific DNA binding site [nucleotide binding]; other site
1036172002587	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1036172002588	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
1036172002589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1036172002590	Fic family protein [Function unknown]; Region: COG3177
1036172002591	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
1036172002592	Fic/DOC family; Region: Fic; pfam02661
1036172002593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036172002594	non-specific DNA binding site [nucleotide binding]; other site
1036172002595	salt bridge; other site
1036172002596	sequence-specific DNA binding site [nucleotide binding]; other site
1036172002597	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1036172002598	active site
1036172002599	Int/Topo IB signature motif; other site
1036172002600	catalytic residues [active]
1036172002601	DNA binding site [nucleotide binding]
1036172002602	RIP metalloprotease RseP; Region: TIGR00054
1036172002603	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1036172002604	active site
1036172002605	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1036172002606	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1036172002607	putative substrate binding region [chemical binding]; other site
1036172002608	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1036172002609	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
1036172002610	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
1036172002611	putative NAD(P) binding site [chemical binding]; other site
1036172002612	active site
1036172002613	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1036172002614	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1036172002615	dimer interface [polypeptide binding]; other site
1036172002616	active site
1036172002617	catalytic residue [active]
1036172002618	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1036172002619	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1036172002620	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1036172002621	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1036172002622	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1036172002623	quinone interaction residues [chemical binding]; other site
1036172002624	active site
1036172002625	catalytic residues [active]
1036172002626	FMN binding site [chemical binding]; other site
1036172002627	substrate binding site [chemical binding]; other site
1036172002628	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036172002629	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172002630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172002631	Walker A/P-loop; other site
1036172002632	ATP binding site [chemical binding]; other site
1036172002633	Q-loop/lid; other site
1036172002634	ABC transporter signature motif; other site
1036172002635	Walker B; other site
1036172002636	D-loop; other site
1036172002637	H-loop/switch region; other site
1036172002638	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1036172002639	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1036172002640	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036172002641	metal binding site 2 [ion binding]; metal-binding site
1036172002642	putative DNA binding helix; other site
1036172002643	metal binding site 1 [ion binding]; metal-binding site
1036172002644	dimer interface [polypeptide binding]; other site
1036172002645	structural Zn2+ binding site [ion binding]; other site
1036172002646	metal-binding heat shock protein; Provisional; Region: PRK00016
1036172002647	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1036172002648	active site 2 [active]
1036172002649	active site 1 [active]
1036172002650	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172002651	MULE transposase domain; Region: MULE; pfam10551
1036172002652	DNA repair protein RadA; Provisional; Region: PRK11823
1036172002653	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1036172002654	Walker A motif/ATP binding site; other site
1036172002655	ATP binding site [chemical binding]; other site
1036172002656	Walker B motif; other site
1036172002657	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1036172002658	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1036172002659	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036172002660	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1036172002661	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
1036172002662	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1036172002663	P loop; other site
1036172002664	GTP binding site [chemical binding]; other site
1036172002665	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1036172002666	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036172002667	catalytic residues [active]
1036172002668	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1036172002669	phosphodiesterase; Provisional; Region: PRK12704
1036172002670	Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508
1036172002671	TFIIA subunit interface [polypeptide binding]; other site
1036172002672	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036172002673	Zn2+ binding site [ion binding]; other site
1036172002674	Mg2+ binding site [ion binding]; other site
1036172002675	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1036172002676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036172002677	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1036172002678	short chain dehydrogenase; Provisional; Region: PRK05993
1036172002679	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1036172002680	NADP binding site [chemical binding]; other site
1036172002681	active site
1036172002682	steroid binding site; other site
1036172002683	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
1036172002684	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1036172002685	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1036172002686	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1036172002687	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1036172002688	Fic/DOC family; Region: Fic; pfam02661
1036172002689	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1036172002690	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1036172002691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172002692	ATP binding site [chemical binding]; other site
1036172002693	putative Mg++ binding site [ion binding]; other site
1036172002694	Cytochrome c [Energy production and conversion]; Region: COG3258
1036172002695	Cytochrome c; Region: Cytochrom_C; pfam00034
1036172002696	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172002697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172002698	active site
1036172002699	phosphorylation site [posttranslational modification]
1036172002700	intermolecular recognition site; other site
1036172002701	dimerization interface [polypeptide binding]; other site
1036172002702	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172002703	DNA binding site [nucleotide binding]
1036172002704	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172002705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172002706	dimer interface [polypeptide binding]; other site
1036172002707	phosphorylation site [posttranslational modification]
1036172002708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172002709	ATP binding site [chemical binding]; other site
1036172002710	Mg2+ binding site [ion binding]; other site
1036172002711	G-X-G motif; other site
1036172002712	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1036172002713	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
1036172002714	dimerization interface [polypeptide binding]; other site
1036172002715	active site
1036172002716	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172002717	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172002718	metal binding site [ion binding]; metal-binding site
1036172002719	active site
1036172002720	I-site; other site
1036172002721	Yqey-like protein; Region: YqeY; pfam09424
1036172002722	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036172002723	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172002724	Walker A/P-loop; other site
1036172002725	ATP binding site [chemical binding]; other site
1036172002726	Q-loop/lid; other site
1036172002727	ABC transporter signature motif; other site
1036172002728	Walker B; other site
1036172002729	D-loop; other site
1036172002730	H-loop/switch region; other site
1036172002731	ABC transporter; Region: ABC_tran_2; pfam12848
1036172002732	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172002733	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1036172002734	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036172002735	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1036172002736	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
1036172002737	active site
1036172002738	Zn binding site [ion binding]; other site
1036172002739	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1036172002740	homotrimer interaction site [polypeptide binding]; other site
1036172002741	putative active site [active]
1036172002742	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1036172002743	hypothetical protein; Validated; Region: PRK00029
1036172002744	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1036172002745	toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116
1036172002746	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1036172002747	GMP synthase; Reviewed; Region: guaA; PRK00074
1036172002748	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1036172002749	AMP/PPi binding site [chemical binding]; other site
1036172002750	candidate oxyanion hole; other site
1036172002751	catalytic triad [active]
1036172002752	potential glutamine specificity residues [chemical binding]; other site
1036172002753	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1036172002754	ATP Binding subdomain [chemical binding]; other site
1036172002755	Ligand Binding sites [chemical binding]; other site
1036172002756	Dimerization subdomain; other site
1036172002757	L-aspartate oxidase; Provisional; Region: PRK06175
1036172002758	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1036172002759	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036172002760	Protein of unknown function (DUF721); Region: DUF721; cl02324
1036172002761	Protein of unknown function DUF45; Region: DUF45; pfam01863
1036172002762	aspartate aminotransferase; Provisional; Region: PRK05764
1036172002763	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172002764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172002765	homodimer interface [polypeptide binding]; other site
1036172002766	catalytic residue [active]
1036172002767	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1036172002768	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1036172002769	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1036172002770	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1036172002771	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
1036172002772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036172002773	S-adenosylmethionine binding site [chemical binding]; other site
1036172002774	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1036172002775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172002776	putative substrate translocation pore; other site
1036172002777	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1036172002778	cobalt transport protein CbiM; Validated; Region: PRK06265
1036172002779	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1036172002780	Cobalt transport protein; Region: CbiQ; cl00463
1036172002781	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172002782	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036172002783	Walker A/P-loop; other site
1036172002784	ATP binding site [chemical binding]; other site
1036172002785	Q-loop/lid; other site
1036172002786	ABC transporter signature motif; other site
1036172002787	Walker B; other site
1036172002788	D-loop; other site
1036172002789	H-loop/switch region; other site
1036172002790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
1036172002791	RelB antitoxin; Region: RelB; cl01171
1036172002792	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1036172002793	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036172002794	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
1036172002795	Domain of unknown function DUF87; Region: DUF87; pfam01935
1036172002796	Zonular occludens toxin (Zot); Region: Zot; cl17485
1036172002797	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1036172002798	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1036172002799	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1036172002800	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1036172002801	PAS fold; Region: PAS; pfam00989
1036172002802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172002803	putative active site [active]
1036172002804	heme pocket [chemical binding]; other site
1036172002805	PAS domain; Region: PAS_8; pfam13188
1036172002806	PAS domain; Region: PAS_9; pfam13426
1036172002807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172002808	putative active site [active]
1036172002809	heme pocket [chemical binding]; other site
1036172002810	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172002811	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172002812	metal binding site [ion binding]; metal-binding site
1036172002813	active site
1036172002814	I-site; other site
1036172002815	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172002816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172002817	PAS fold; Region: PAS_3; pfam08447
1036172002818	putative active site [active]
1036172002819	heme pocket [chemical binding]; other site
1036172002820	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172002821	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172002822	dimer interface [polypeptide binding]; other site
1036172002823	putative CheW interface [polypeptide binding]; other site
1036172002824	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839
1036172002825	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036172002826	serine O-acetyltransferase; Region: cysE; TIGR01172
1036172002827	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1036172002828	trimer interface [polypeptide binding]; other site
1036172002829	active site
1036172002830	substrate binding site [chemical binding]; other site
1036172002831	CoA binding site [chemical binding]; other site
1036172002832	arginine decarboxylase; Provisional; Region: PRK05354
1036172002833	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1036172002834	dimer interface [polypeptide binding]; other site
1036172002835	active site
1036172002836	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036172002837	catalytic residues [active]
1036172002838	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1036172002839	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1036172002840	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1036172002841	dimer interface [polypeptide binding]; other site
1036172002842	motif 1; other site
1036172002843	active site
1036172002844	motif 2; other site
1036172002845	motif 3; other site
1036172002846	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1036172002847	anticodon binding site; other site
1036172002848	thymidylate kinase; Validated; Region: tmk; PRK00698
1036172002849	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1036172002850	TMP-binding site; other site
1036172002851	ATP-binding site [chemical binding]; other site
1036172002852	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1036172002853	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1036172002854	active site
1036172002855	(T/H)XGH motif; other site
1036172002856	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1036172002857	Flavoprotein; Region: Flavoprotein; pfam02441
1036172002858	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1036172002859	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1036172002860	catalytic residues [active]
1036172002861	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1036172002862	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1036172002863	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1036172002864	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1036172002865	active site
1036172002866	HslU subunit interaction site [polypeptide binding]; other site
1036172002867	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1036172002868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172002869	Walker A motif; other site
1036172002870	ATP binding site [chemical binding]; other site
1036172002871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172002872	Walker B motif; other site
1036172002873	arginine finger; other site
1036172002874	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1036172002875	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1036172002876	active site
1036172002877	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1036172002878	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1036172002879	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1036172002880	catalytic residue [active]
1036172002881	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1036172002882	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1036172002883	Sporulation related domain; Region: SPOR; pfam05036
1036172002884	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1036172002885	putative active site pocket [active]
1036172002886	4-fold oligomerization interface [polypeptide binding]; other site
1036172002887	metal binding residues [ion binding]; metal-binding site
1036172002888	3-fold/trimer interface [polypeptide binding]; other site
1036172002889	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1036172002890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172002891	active site
1036172002892	motif I; other site
1036172002893	motif II; other site
1036172002894	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1036172002895	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1036172002896	OstA-like protein; Region: OstA; pfam03968
1036172002897	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1036172002898	G1 box; other site
1036172002899	GTP/Mg2+ binding site [chemical binding]; other site
1036172002900	Switch I region; other site
1036172002901	G2 box; other site
1036172002902	G3 box; other site
1036172002903	Switch II region; other site
1036172002904	G4 box; other site
1036172002905	G5 box; other site
1036172002906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172002907	Coenzyme A binding pocket [chemical binding]; other site
1036172002908	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1036172002909	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036172002910	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036172002911	DNA binding residues [nucleotide binding]
1036172002912	FecR protein; Region: FecR; pfam04773
1036172002913	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1036172002914	Secretin and TonB N terminus short domain; Region: STN; smart00965
1036172002915	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172002916	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172002917	N-terminal plug; other site
1036172002918	ligand-binding site [chemical binding]; other site
1036172002919	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1036172002920	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1036172002921	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1036172002922	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
1036172002923	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1036172002924	synthetase active site [active]
1036172002925	NTP binding site [chemical binding]; other site
1036172002926	metal binding site [ion binding]; metal-binding site
1036172002927	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1036172002928	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036172002929	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1036172002930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172002931	PAS domain; Region: PAS_9; pfam13426
1036172002932	putative active site [active]
1036172002933	heme pocket [chemical binding]; other site
1036172002934	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036172002935	Zn2+ binding site [ion binding]; other site
1036172002936	Mg2+ binding site [ion binding]; other site
1036172002937	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1036172002938	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1036172002939	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036172002940	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036172002941	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036172002942	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036172002943	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172002944	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036172002945	Walker A/P-loop; other site
1036172002946	ATP binding site [chemical binding]; other site
1036172002947	Q-loop/lid; other site
1036172002948	ABC transporter signature motif; other site
1036172002949	Walker B; other site
1036172002950	D-loop; other site
1036172002951	H-loop/switch region; other site
1036172002952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172002953	S-adenosylmethionine binding site [chemical binding]; other site
1036172002954	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1036172002955	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036172002956	Interdomain contacts; other site
1036172002957	Cytokine receptor motif; other site
1036172002958	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036172002959	Interdomain contacts; other site
1036172002960	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036172002961	Interdomain contacts; other site
1036172002962	Cytokine receptor motif; other site
1036172002963	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036172002964	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172002965	RNA binding surface [nucleotide binding]; other site
1036172002966	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036172002967	active site
1036172002968	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1036172002969	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1036172002970	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1036172002971	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036172002972	inhibitor-cofactor binding pocket; inhibition site
1036172002973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172002974	catalytic residue [active]
1036172002975	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1036172002976	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
1036172002977	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1036172002978	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1036172002979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036172002980	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036172002981	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036172002982	DNA binding residues [nucleotide binding]
1036172002983	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
1036172002984	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1036172002985	substrate binding site [chemical binding]; other site
1036172002986	tartrate dehydrogenase; Region: TTC; TIGR02089
1036172002987	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1036172002988	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1036172002989	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1036172002990	HIT family signature motif; other site
1036172002991	catalytic residue [active]
1036172002992	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1036172002993	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1036172002994	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1036172002995	30S ribosomal protein S11; Validated; Region: PRK05309
1036172002996	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1036172002997	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1036172002998	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172002999	RNA binding surface [nucleotide binding]; other site
1036172003000	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1036172003001	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1036172003002	alphaNTD homodimer interface [polypeptide binding]; other site
1036172003003	alphaNTD - beta interaction site [polypeptide binding]; other site
1036172003004	alphaNTD - beta' interaction site [polypeptide binding]; other site
1036172003005	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1036172003006	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1036172003007	indole-3-acetamide amidohydrolase; Region: PLN02722
1036172003008	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1036172003009	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1036172003010	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036172003011	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1036172003012	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1036172003013	active site
1036172003014	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1036172003015	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036172003016	HSP70 interaction site [polypeptide binding]; other site
1036172003017	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036172003018	HSP70 interaction site [polypeptide binding]; other site
1036172003019	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036172003020	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1036172003021	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1036172003022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003023	Walker A/P-loop; other site
1036172003024	ATP binding site [chemical binding]; other site
1036172003025	Q-loop/lid; other site
1036172003026	ABC transporter signature motif; other site
1036172003027	Walker B; other site
1036172003028	D-loop; other site
1036172003029	H-loop/switch region; other site
1036172003030	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
1036172003031	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036172003032	tetramer interface [polypeptide binding]; other site
1036172003033	catalytic Zn binding site [ion binding]; other site
1036172003034	NADP binding site [chemical binding]; other site
1036172003035	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036172003036	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036172003037	ligand binding site [chemical binding]; other site
1036172003038	flexible hinge region; other site
1036172003039	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036172003040	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036172003041	dimerization interface [polypeptide binding]; other site
1036172003042	putative DNA binding site [nucleotide binding]; other site
1036172003043	putative Zn2+ binding site [ion binding]; other site
1036172003044	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036172003045	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1036172003046	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1036172003047	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1036172003048	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036172003049	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036172003050	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036172003051	active site
1036172003052	catalytic tetrad [active]
1036172003053	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1036172003054	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1036172003055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036172003056	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1036172003057	putative dimerization interface [polypeptide binding]; other site
1036172003058	Predicted membrane protein [Function unknown]; Region: COG2855
1036172003059	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1036172003060	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036172003061	substrate binding pocket [chemical binding]; other site
1036172003062	membrane-bound complex binding site; other site
1036172003063	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1036172003064	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1036172003065	active site
1036172003066	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1036172003067	dinuclear metal binding motif [ion binding]; other site
1036172003068	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1036172003069	dimerization domain [polypeptide binding]; other site
1036172003070	dimer interface [polypeptide binding]; other site
1036172003071	catalytic residues [active]
1036172003072	Membrane transport protein; Region: Mem_trans; cl09117
1036172003073	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036172003074	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036172003075	dimerization interface [polypeptide binding]; other site
1036172003076	putative DNA binding site [nucleotide binding]; other site
1036172003077	putative Zn2+ binding site [ion binding]; other site
1036172003078	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1036172003079	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1036172003080	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036172003081	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1036172003082	active site
1036172003083	FMN binding site [chemical binding]; other site
1036172003084	substrate binding site [chemical binding]; other site
1036172003085	homotetramer interface [polypeptide binding]; other site
1036172003086	catalytic residue [active]
1036172003087	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036172003088	EamA-like transporter family; Region: EamA; pfam00892
1036172003089	EamA-like transporter family; Region: EamA; pfam00892
1036172003090	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1036172003091	dimer interface [polypeptide binding]; other site
1036172003092	FMN binding site [chemical binding]; other site
1036172003093	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
1036172003094	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1036172003095	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003096	Walker A/P-loop; other site
1036172003097	ATP binding site [chemical binding]; other site
1036172003098	Q-loop/lid; other site
1036172003099	ABC transporter signature motif; other site
1036172003100	Walker B; other site
1036172003101	D-loop; other site
1036172003102	H-loop/switch region; other site
1036172003103	ABC transporter; Region: ABC_tran_2; pfam12848
1036172003104	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172003105	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1036172003106	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172003107	dimer interface [polypeptide binding]; other site
1036172003108	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172003109	putative CheW interface [polypeptide binding]; other site
1036172003110	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1036172003111	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1036172003112	nucleotide binding pocket [chemical binding]; other site
1036172003113	K-X-D-G motif; other site
1036172003114	catalytic site [active]
1036172003115	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1036172003116	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1036172003117	Dimer interface [polypeptide binding]; other site
1036172003118	BRCT sequence motif; other site
1036172003119	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1036172003120	hypothetical protein; Provisional; Region: PRK04081
1036172003121	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1036172003122	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
1036172003123	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1036172003124	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1036172003125	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1036172003126	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1036172003127	shikimate binding site; other site
1036172003128	NAD(P) binding site [chemical binding]; other site
1036172003129	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036172003130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172003131	S-adenosylmethionine binding site [chemical binding]; other site
1036172003132	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1036172003133	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1036172003134	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1036172003135	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1036172003136	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1036172003137	putative active site [active]
1036172003138	putative substrate binding site [chemical binding]; other site
1036172003139	putative cosubstrate binding site; other site
1036172003140	catalytic site [active]
1036172003141	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1036172003142	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
1036172003143	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1036172003144	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1036172003145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003147	active site
1036172003148	phosphorylation site [posttranslational modification]
1036172003149	intermolecular recognition site; other site
1036172003150	dimerization interface [polypeptide binding]; other site
1036172003151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172003152	DNA binding site [nucleotide binding]
1036172003153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172003155	phosphorylation site [posttranslational modification]
1036172003156	dimer interface [polypeptide binding]; other site
1036172003157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003158	ATP binding site [chemical binding]; other site
1036172003159	Mg2+ binding site [ion binding]; other site
1036172003160	G-X-G motif; other site
1036172003161	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1036172003162	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1036172003163	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
1036172003164	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1036172003165	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1036172003166	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1036172003167	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1036172003168	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1036172003169	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
1036172003170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036172003171	TPR motif; other site
1036172003172	TPR repeat; Region: TPR_11; pfam13414
1036172003173	binding surface
1036172003174	Protein of unknown function, DUF393; Region: DUF393; cl01136
1036172003175	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1036172003176	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1036172003177	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1036172003178	active site
1036172003179	uracil binding [chemical binding]; other site
1036172003180	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036172003181	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172003182	motif II; other site
1036172003183	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1036172003184	Family description; Region: DsbD_2; pfam13386
1036172003185	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1036172003186	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172003187	N-terminal plug; other site
1036172003188	ligand-binding site [chemical binding]; other site
1036172003189	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036172003190	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036172003191	intersubunit interface [polypeptide binding]; other site
1036172003192	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036172003193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003194	Walker A/P-loop; other site
1036172003195	ATP binding site [chemical binding]; other site
1036172003196	Q-loop/lid; other site
1036172003197	ABC transporter signature motif; other site
1036172003198	Walker B; other site
1036172003199	D-loop; other site
1036172003200	H-loop/switch region; other site
1036172003201	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036172003202	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036172003203	ABC-ATPase subunit  interface; other site
1036172003204	dimer interface [polypeptide binding]; other site
1036172003205	putative PBP binding regions; other site
1036172003206	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036172003207	catalytic core [active]
1036172003208	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036172003209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172003210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003211	Walker A/P-loop; other site
1036172003212	ATP binding site [chemical binding]; other site
1036172003213	Q-loop/lid; other site
1036172003214	ABC transporter signature motif; other site
1036172003215	Walker B; other site
1036172003216	D-loop; other site
1036172003217	H-loop/switch region; other site
1036172003218	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003220	active site
1036172003221	phosphorylation site [posttranslational modification]
1036172003222	intermolecular recognition site; other site
1036172003223	dimerization interface [polypeptide binding]; other site
1036172003224	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172003225	DNA binding site [nucleotide binding]
1036172003226	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1036172003227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172003228	dimer interface [polypeptide binding]; other site
1036172003229	phosphorylation site [posttranslational modification]
1036172003230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003231	ATP binding site [chemical binding]; other site
1036172003232	Mg2+ binding site [ion binding]; other site
1036172003233	G-X-G motif; other site
1036172003234	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1036172003235	flagellin; Provisional; Region: PRK12802
1036172003236	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1036172003237	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036172003238	active site
1036172003239	catalytic site [active]
1036172003240	substrate binding site [chemical binding]; other site
1036172003241	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1036172003242	putative Mg++ binding site [ion binding]; other site
1036172003243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172003244	nucleotide binding region [chemical binding]; other site
1036172003245	ATP-binding site [chemical binding]; other site
1036172003246	PAS domain S-box; Region: sensory_box; TIGR00229
1036172003247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036172003248	putative active site [active]
1036172003249	heme pocket [chemical binding]; other site
1036172003250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003252	ATP binding site [chemical binding]; other site
1036172003253	Mg2+ binding site [ion binding]; other site
1036172003254	G-X-G motif; other site
1036172003255	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172003256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003257	active site
1036172003258	phosphorylation site [posttranslational modification]
1036172003259	intermolecular recognition site; other site
1036172003260	dimerization interface [polypeptide binding]; other site
1036172003261	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172003262	DNA binding site [nucleotide binding]
1036172003263	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1036172003264	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1036172003265	ligand binding site [chemical binding]; other site
1036172003266	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172003267	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172003268	ligand binding site [chemical binding]; other site
1036172003269	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
1036172003270	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1036172003271	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172003272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003273	Walker A/P-loop; other site
1036172003274	ATP binding site [chemical binding]; other site
1036172003275	Q-loop/lid; other site
1036172003276	ABC transporter signature motif; other site
1036172003277	Walker B; other site
1036172003278	D-loop; other site
1036172003279	H-loop/switch region; other site
1036172003280	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1036172003281	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036172003282	E3 interaction surface; other site
1036172003283	lipoyl attachment site [posttranslational modification]; other site
1036172003284	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172003285	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036172003286	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036172003287	DNA binding residues [nucleotide binding]
1036172003288	dimerization interface [polypeptide binding]; other site
1036172003289	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
1036172003290	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172003291	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172003292	metal binding site [ion binding]; metal-binding site
1036172003293	active site
1036172003294	I-site; other site
1036172003295	EAL domain; Region: EAL; pfam00563
1036172003296	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1036172003297	active site
1036172003298	dimer interface [polypeptide binding]; other site
1036172003299	metal binding site [ion binding]; metal-binding site
1036172003300	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1036172003301	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1036172003302	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036172003303	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
1036172003304	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172003305	FeS/SAM binding site; other site
1036172003306	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1036172003307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172003308	Walker B motif; other site
1036172003309	arginine finger; other site
1036172003310	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1036172003311	MPT binding site; other site
1036172003312	trimer interface [polypeptide binding]; other site
1036172003313	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1036172003314	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1036172003315	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036172003316	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036172003317	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036172003318	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172003319	Coenzyme A binding pocket [chemical binding]; other site
1036172003320	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036172003321	non-specific DNA binding site [nucleotide binding]; other site
1036172003322	salt bridge; other site
1036172003323	sequence-specific DNA binding site [nucleotide binding]; other site
1036172003324	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036172003325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172003326	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1036172003327	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172003328	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036172003329	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
1036172003330	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1036172003331	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1036172003332	molybdopterin cofactor binding site [chemical binding]; other site
1036172003333	substrate binding site [chemical binding]; other site
1036172003334	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1036172003335	molybdopterin cofactor binding site; other site
1036172003336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036172003337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036172003338	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1036172003339	MutS domain III; Region: MutS_III; cl17822
1036172003340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003341	Walker A/P-loop; other site
1036172003342	ATP binding site [chemical binding]; other site
1036172003343	Q-loop/lid; other site
1036172003344	ABC transporter signature motif; other site
1036172003345	Walker B; other site
1036172003346	D-loop; other site
1036172003347	H-loop/switch region; other site
1036172003348	Smr domain; Region: Smr; pfam01713
1036172003349	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1036172003350	Domain of unknown function DUF21; Region: DUF21; pfam01595
1036172003351	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1036172003352	Transporter associated domain; Region: CorC_HlyC; smart01091
1036172003353	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1036172003354	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1036172003355	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1036172003356	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1036172003357	metal binding site [ion binding]; metal-binding site
1036172003358	dimer interface [polypeptide binding]; other site
1036172003359	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1036172003360	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1036172003361	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1036172003362	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1036172003363	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
1036172003364	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1036172003365	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036172003366	nucleotide binding site [chemical binding]; other site
1036172003367	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527
1036172003368	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036172003369	PYR/PP interface [polypeptide binding]; other site
1036172003370	dimer interface [polypeptide binding]; other site
1036172003371	TPP binding site [chemical binding]; other site
1036172003372	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036172003373	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1036172003374	TPP-binding site [chemical binding]; other site
1036172003375	dimer interface [polypeptide binding]; other site
1036172003376	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1036172003377	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1036172003378	putative valine binding site [chemical binding]; other site
1036172003379	dimer interface [polypeptide binding]; other site
1036172003380	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1036172003381	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1036172003382	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1036172003383	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1036172003384	trimer interface [polypeptide binding]; other site
1036172003385	active site
1036172003386	UDP-GlcNAc binding site [chemical binding]; other site
1036172003387	lipid binding site [chemical binding]; lipid-binding site
1036172003388	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1036172003389	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1036172003390	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1036172003391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003393	active site
1036172003394	phosphorylation site [posttranslational modification]
1036172003395	intermolecular recognition site; other site
1036172003396	dimerization interface [polypeptide binding]; other site
1036172003397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172003398	DNA binding site [nucleotide binding]
1036172003399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003400	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036172003401	dimerization interface [polypeptide binding]; other site
1036172003402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003403	ATP binding site [chemical binding]; other site
1036172003404	Mg2+ binding site [ion binding]; other site
1036172003405	G-X-G motif; other site
1036172003406	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1036172003407	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036172003408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1036172003409	Histidine kinase; Region: HisKA_2; pfam07568
1036172003410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003411	ATP binding site [chemical binding]; other site
1036172003412	Mg2+ binding site [ion binding]; other site
1036172003413	G-X-G motif; other site
1036172003414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003416	active site
1036172003417	phosphorylation site [posttranslational modification]
1036172003418	intermolecular recognition site; other site
1036172003419	dimerization interface [polypeptide binding]; other site
1036172003420	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172003421	DNA binding site [nucleotide binding]
1036172003422	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003424	active site
1036172003425	phosphorylation site [posttranslational modification]
1036172003426	intermolecular recognition site; other site
1036172003427	dimerization interface [polypeptide binding]; other site
1036172003428	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172003429	DNA binding site [nucleotide binding]
1036172003430	HTH domain; Region: HTH_11; cl17392
1036172003431	WYL domain; Region: WYL; pfam13280
1036172003432	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1036172003433	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1036172003434	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1036172003435	RTX toxin acyltransferase family; Region: HlyC; pfam02794
1036172003436	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1036172003437	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1036172003438	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
1036172003439	putative active site [active]
1036172003440	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036172003441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003442	Walker A/P-loop; other site
1036172003443	ATP binding site [chemical binding]; other site
1036172003444	Q-loop/lid; other site
1036172003445	ABC transporter signature motif; other site
1036172003446	Walker B; other site
1036172003447	D-loop; other site
1036172003448	H-loop/switch region; other site
1036172003449	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1036172003450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036172003451	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172003452	SEC-C motif; Region: SEC-C; pfam02810
1036172003453	hypothetical protein; Provisional; Region: PRK04233
1036172003454	exonuclease subunit SbcD; Provisional; Region: PRK10966
1036172003455	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1036172003456	active site
1036172003457	metal binding site [ion binding]; metal-binding site
1036172003458	DNA binding site [nucleotide binding]
1036172003459	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1036172003460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003461	AAA domain; Region: AAA_23; pfam13476
1036172003462	Walker A/P-loop; other site
1036172003463	ATP binding site [chemical binding]; other site
1036172003464	Q-loop/lid; other site
1036172003465	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003466	ABC transporter signature motif; other site
1036172003467	Walker B; other site
1036172003468	D-loop; other site
1036172003469	H-loop/switch region; other site
1036172003470	WYL domain; Region: WYL; cl14852
1036172003471	AAA domain; Region: AAA_13; pfam13166
1036172003472	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172003473	Walker B; other site
1036172003474	D-loop; other site
1036172003475	H-loop/switch region; other site
1036172003476	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
1036172003477	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1036172003478	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1036172003479	Part of AAA domain; Region: AAA_19; pfam13245
1036172003480	AAA domain; Region: AAA_12; pfam13087
1036172003481	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1036172003482	HipA N-terminal domain; Region: Couple_hipA; cl11853
1036172003483	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1036172003484	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1036172003485	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1036172003486	30S subunit binding site; other site
1036172003487	GTP-binding protein Der; Reviewed; Region: PRK00093
1036172003488	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1036172003489	G1 box; other site
1036172003490	GTP/Mg2+ binding site [chemical binding]; other site
1036172003491	Switch I region; other site
1036172003492	G2 box; other site
1036172003493	Switch II region; other site
1036172003494	G3 box; other site
1036172003495	G4 box; other site
1036172003496	G5 box; other site
1036172003497	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1036172003498	G1 box; other site
1036172003499	GTP/Mg2+ binding site [chemical binding]; other site
1036172003500	Switch I region; other site
1036172003501	G2 box; other site
1036172003502	G3 box; other site
1036172003503	Switch II region; other site
1036172003504	G4 box; other site
1036172003505	G5 box; other site
1036172003506	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1036172003507	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1036172003508	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1036172003509	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1036172003510	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1036172003511	active site
1036172003512	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1036172003513	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1036172003514	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1036172003515	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1036172003516	RDD family; Region: RDD; pfam06271
1036172003517	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1036172003518	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1036172003519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172003520	active site
1036172003521	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1036172003522	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1036172003523	oligomer interface [polypeptide binding]; other site
1036172003524	RNA binding site [nucleotide binding]; other site
1036172003525	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1036172003526	RNase E interface [polypeptide binding]; other site
1036172003527	trimer interface [polypeptide binding]; other site
1036172003528	active site
1036172003529	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1036172003530	putative nucleic acid binding region [nucleotide binding]; other site
1036172003531	G-X-X-G motif; other site
1036172003532	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036172003533	RNA binding site [nucleotide binding]; other site
1036172003534	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172003535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003536	active site
1036172003537	phosphorylation site [posttranslational modification]
1036172003538	intermolecular recognition site; other site
1036172003539	dimerization interface [polypeptide binding]; other site
1036172003540	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1036172003541	putative binding surface; other site
1036172003542	active site
1036172003543	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1036172003544	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1036172003545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003546	ATP binding site [chemical binding]; other site
1036172003547	Mg2+ binding site [ion binding]; other site
1036172003548	G-X-G motif; other site
1036172003549	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1036172003550	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1036172003551	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1036172003552	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1036172003553	CheD chemotactic sensory transduction; Region: CheD; cl00810
1036172003554	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1036172003555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003556	active site
1036172003557	phosphorylation site [posttranslational modification]
1036172003558	intermolecular recognition site; other site
1036172003559	dimerization interface [polypeptide binding]; other site
1036172003560	CheB methylesterase; Region: CheB_methylest; pfam01339
1036172003561	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1036172003562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172003563	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172003564	putative substrate translocation pore; other site
1036172003565	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036172003566	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1036172003567	active site
1036172003568	DNA binding site [nucleotide binding]
1036172003569	Int/Topo IB signature motif; other site
1036172003570	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1036172003571	putative active site [active]
1036172003572	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1036172003573	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1036172003574	active site
1036172003575	Zn binding site [ion binding]; other site
1036172003576	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1036172003577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172003578	S-adenosylmethionine binding site [chemical binding]; other site
1036172003579	coproporphyrinogen III oxidase; Provisional; Region: PRK08446
1036172003580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172003581	FeS/SAM binding site; other site
1036172003582	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1036172003583	putative active site [active]
1036172003584	Ap4A binding site [chemical binding]; other site
1036172003585	nudix motif; other site
1036172003586	putative metal binding site [ion binding]; other site
1036172003587	aspartate kinase; Reviewed; Region: PRK06635
1036172003588	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1036172003589	putative nucleotide binding site [chemical binding]; other site
1036172003590	putative catalytic residues [active]
1036172003591	putative Mg ion binding site [ion binding]; other site
1036172003592	putative aspartate binding site [chemical binding]; other site
1036172003593	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1036172003594	putative allosteric regulatory site; other site
1036172003595	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1036172003596	DNA replication regulator; Region: HobA; pfam12163
1036172003597	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1036172003598	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1036172003599	dihydropteroate synthase; Region: DHPS; TIGR01496
1036172003600	substrate binding pocket [chemical binding]; other site
1036172003601	dimer interface [polypeptide binding]; other site
1036172003602	inhibitor binding site; inhibition site
1036172003603	prephenate dehydrogenase; Validated; Region: PRK08507
1036172003604	Prephenate dehydrogenase; Region: PDH; pfam02153
1036172003605	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1036172003606	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1036172003607	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1036172003608	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1036172003609	Surface antigen; Region: Bac_surface_Ag; pfam01103
1036172003610	hypothetical protein; Provisional; Region: PRK08445
1036172003611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172003612	FeS/SAM binding site; other site
1036172003613	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1036172003614	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1036172003615	glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410
1036172003616	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036172003617	active site
1036172003618	HIGH motif; other site
1036172003619	nucleotide binding site [chemical binding]; other site
1036172003620	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036172003621	active site
1036172003622	KMSKS motif; other site
1036172003623	YGGT family; Region: YGGT; pfam02325
1036172003624	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1036172003625	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1036172003626	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1036172003627	catalytic residue [active]
1036172003628	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1036172003629	Walker A motif; other site
1036172003630	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1036172003631	metal binding site [ion binding]; metal-binding site
1036172003632	active site
1036172003633	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1036172003634	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1036172003635	active site
1036172003636	HIGH motif; other site
1036172003637	KMSKS motif; other site
1036172003638	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1036172003639	anticodon binding site; other site
1036172003640	tRNA binding surface [nucleotide binding]; other site
1036172003641	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1036172003642	dimer interface [polypeptide binding]; other site
1036172003643	putative tRNA-binding site [nucleotide binding]; other site
1036172003644	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1036172003645	Predicted transcriptional regulator [Transcription]; Region: COG2932
1036172003646	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1036172003647	Catalytic site [active]
1036172003648	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
1036172003649	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
1036172003650	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1036172003651	active site
1036172003652	catalytic residues [active]
1036172003653	metal binding site [ion binding]; metal-binding site
1036172003654	homodimer binding site [polypeptide binding]; other site
1036172003655	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1036172003656	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036172003657	carboxyltransferase (CT) interaction site; other site
1036172003658	biotinylation site [posttranslational modification]; other site
1036172003659	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1036172003660	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1036172003661	active site
1036172003662	substrate-binding site [chemical binding]; other site
1036172003663	metal-binding site [ion binding]
1036172003664	ATP binding site [chemical binding]; other site
1036172003665	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
1036172003666	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1036172003667	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
1036172003668	active site
1036172003669	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1036172003670	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
1036172003671	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1036172003672	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1036172003673	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1036172003674	dimerization interface [polypeptide binding]; other site
1036172003675	active site
1036172003676	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1036172003677	dimer interface [polypeptide binding]; other site
1036172003678	active site
1036172003679	Schiff base residues; other site
1036172003680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172003681	PAS domain; Region: PAS_9; pfam13426
1036172003682	putative active site [active]
1036172003683	heme pocket [chemical binding]; other site
1036172003684	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003686	ATP binding site [chemical binding]; other site
1036172003687	Mg2+ binding site [ion binding]; other site
1036172003688	G-X-G motif; other site
1036172003689	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003691	active site
1036172003692	phosphorylation site [posttranslational modification]
1036172003693	intermolecular recognition site; other site
1036172003694	dimerization interface [polypeptide binding]; other site
1036172003695	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172003696	DNA binding site [nucleotide binding]
1036172003697	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
1036172003698	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172003699	FeS/SAM binding site; other site
1036172003700	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
1036172003701	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
1036172003702	ATP cone domain; Region: ATP-cone; pfam03477
1036172003703	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1036172003704	effector binding site; other site
1036172003705	active site
1036172003706	Zn binding site [ion binding]; other site
1036172003707	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1036172003708	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1036172003709	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1036172003710	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1036172003711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172003712	FeS/SAM binding site; other site
1036172003713	HemN C-terminal domain; Region: HemN_C; pfam06969
1036172003714	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1036172003715	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1036172003716	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1036172003717	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036172003718	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172003719	catalytic residue [active]
1036172003720	NAD synthetase; Provisional; Region: PRK13980
1036172003721	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1036172003722	homodimer interface [polypeptide binding]; other site
1036172003723	NAD binding pocket [chemical binding]; other site
1036172003724	ATP binding pocket [chemical binding]; other site
1036172003725	Mg binding site [ion binding]; other site
1036172003726	active-site loop [active]
1036172003727	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036172003728	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1036172003729	putative metal binding site [ion binding]; other site
1036172003730	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036172003731	HSP70 interaction site [polypeptide binding]; other site
1036172003732	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1036172003733	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1036172003734	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1036172003735	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1036172003736	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
1036172003737	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036172003738	active site
1036172003739	catalytic site [active]
1036172003740	substrate binding site [chemical binding]; other site
1036172003741	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172003742	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172003743	N-terminal plug; other site
1036172003744	ligand-binding site [chemical binding]; other site
1036172003745	Competence protein; Region: Competence; pfam03772
1036172003746	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172003747	MULE transposase domain; Region: MULE; pfam10551
1036172003748	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
1036172003749	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1036172003750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172003751	S-adenosylmethionine binding site [chemical binding]; other site
1036172003752	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1036172003753	putative active site pocket [active]
1036172003754	dimerization interface [polypeptide binding]; other site
1036172003755	putative catalytic residue [active]
1036172003756	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036172003757	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036172003758	Cysteine-rich domain; Region: CCG; pfam02754
1036172003759	Cysteine-rich domain; Region: CCG; pfam02754
1036172003760	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1036172003761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1036172003762	active site
1036172003763	phosphorylation site [posttranslational modification]
1036172003764	intermolecular recognition site; other site
1036172003765	dimerization interface [polypeptide binding]; other site
1036172003766	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172003767	DNA polymerase I; Provisional; Region: PRK05755
1036172003768	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1036172003769	active site
1036172003770	metal binding site 1 [ion binding]; metal-binding site
1036172003771	putative 5' ssDNA interaction site; other site
1036172003772	metal binding site 3; metal-binding site
1036172003773	metal binding site 2 [ion binding]; metal-binding site
1036172003774	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1036172003775	putative DNA binding site [nucleotide binding]; other site
1036172003776	putative metal binding site [ion binding]; other site
1036172003777	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1036172003778	active site
1036172003779	catalytic site [active]
1036172003780	substrate binding site [chemical binding]; other site
1036172003781	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1036172003782	active site
1036172003783	DNA binding site [nucleotide binding]
1036172003784	catalytic site [active]
1036172003785	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1036172003786	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1036172003787	Ligand binding site; other site
1036172003788	oligomer interface; other site
1036172003789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172003790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172003791	metal binding site [ion binding]; metal-binding site
1036172003792	active site
1036172003793	I-site; other site
1036172003794	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172003795	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1036172003796	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1036172003797	Walker A/P-loop; other site
1036172003798	ATP binding site [chemical binding]; other site
1036172003799	Q-loop/lid; other site
1036172003800	ABC transporter signature motif; other site
1036172003801	Walker B; other site
1036172003802	D-loop; other site
1036172003803	H-loop/switch region; other site
1036172003804	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1036172003805	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036172003806	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1036172003807	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1036172003808	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
1036172003809	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172003810	RNA binding surface [nucleotide binding]; other site
1036172003811	argininosuccinate synthase; Provisional; Region: PRK13820
1036172003812	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1036172003813	ANP binding site [chemical binding]; other site
1036172003814	Substrate Binding Site II [chemical binding]; other site
1036172003815	Substrate Binding Site I [chemical binding]; other site
1036172003816	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1036172003817	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1036172003818	acyl-activating enzyme (AAE) consensus motif; other site
1036172003819	AMP binding site [chemical binding]; other site
1036172003820	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1036172003821	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1036172003822	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1036172003823	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1036172003824	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1036172003825	trimer interface [polypeptide binding]; other site
1036172003826	putative metal binding site [ion binding]; other site
1036172003827	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1036172003828	TrkA-N domain; Region: TrkA_N; pfam02254
1036172003829	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1036172003830	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1036172003831	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172003832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003833	active site
1036172003834	dimerization interface [polypeptide binding]; other site
1036172003835	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172003836	DNA binding site [nucleotide binding]
1036172003837	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1036172003838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172003839	dimer interface [polypeptide binding]; other site
1036172003840	phosphorylation site [posttranslational modification]
1036172003841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003842	ATP binding site [chemical binding]; other site
1036172003843	Mg2+ binding site [ion binding]; other site
1036172003844	G-X-G motif; other site
1036172003845	dUTPase; Region: dUTPase_2; pfam08761
1036172003846	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
1036172003847	active site
1036172003848	homodimer interface [polypeptide binding]; other site
1036172003849	metal binding site [ion binding]; metal-binding site
1036172003850	Pleckstrin homology-like domain; Region: PH-like; cl17171
1036172003851	recombination protein RecR; Reviewed; Region: recR; PRK00076
1036172003852	RecR protein; Region: RecR; pfam02132
1036172003853	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1036172003854	putative active site [active]
1036172003855	putative metal-binding site [ion binding]; other site
1036172003856	tetramer interface [polypeptide binding]; other site
1036172003857	chaperone protein DnaJ; Provisional; Region: PRK10767
1036172003858	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036172003859	HSP70 interaction site [polypeptide binding]; other site
1036172003860	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1036172003861	Zn binding sites [ion binding]; other site
1036172003862	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1036172003863	dimer interface [polypeptide binding]; other site
1036172003864	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1036172003865	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1036172003866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172003867	catalytic residue [active]
1036172003868	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1036172003869	dinuclear metal binding motif [ion binding]; other site
1036172003870	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036172003871	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172003872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172003873	metal binding site [ion binding]; metal-binding site
1036172003874	active site
1036172003875	I-site; other site
1036172003876	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172003877	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172003878	metal binding site [ion binding]; metal-binding site
1036172003879	active site
1036172003880	I-site; other site
1036172003881	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036172003882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172003883	S-adenosylmethionine binding site [chemical binding]; other site
1036172003884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036172003885	ResB-like family; Region: ResB; pfam05140
1036172003886	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1036172003887	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1036172003888	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1036172003889	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1036172003890	metal binding site [ion binding]; metal-binding site
1036172003891	diacylglycerol kinase/D-erythro-sphingosine kinase; Region: PLN02958
1036172003892	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172003893	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172003894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172003895	dimer interface [polypeptide binding]; other site
1036172003896	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172003897	putative CheW interface [polypeptide binding]; other site
1036172003898	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1036172003899	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1036172003900	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1036172003901	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1036172003902	ATP binding site [chemical binding]; other site
1036172003903	putative Mg++ binding site [ion binding]; other site
1036172003904	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1036172003905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172003906	nucleotide binding region [chemical binding]; other site
1036172003907	ATP-binding site [chemical binding]; other site
1036172003908	SEC-C motif; Region: SEC-C; pfam02810
1036172003909	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1036172003910	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036172003911	FtsX-like permease family; Region: FtsX; pfam02687
1036172003912	Protein of unknown function; Region: DUF3971; pfam13116
1036172003913	AsmA-like C-terminal region; Region: AsmA_1; pfam13109
1036172003914	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1036172003915	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1036172003916	dimerization interface [polypeptide binding]; other site
1036172003917	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1036172003918	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1036172003919	malate dehydrogenase; Reviewed; Region: PRK06223
1036172003920	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1036172003921	NAD(P) binding site [chemical binding]; other site
1036172003922	dimer interface [polypeptide binding]; other site
1036172003923	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036172003924	substrate binding site [chemical binding]; other site
1036172003925	Cytochrome c; Region: Cytochrom_C; cl11414
1036172003926	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
1036172003927	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
1036172003928	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
1036172003929	NlpC/P60 family; Region: NLPC_P60; cl17555
1036172003930	MraW methylase family; Region: Methyltransf_5; cl17771
1036172003931	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1036172003932	hypothetical protein; Provisional; Region: PRK05834
1036172003933	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1036172003934	IHF dimer interface [polypeptide binding]; other site
1036172003935	IHF - DNA interface [nucleotide binding]; other site
1036172003936	genetic element 2
1036172003937	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1036172003938	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172003939	MULE transposase domain; Region: MULE; pfam10551
1036172003940	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1036172003941	Type IV secretion system proteins; Region: T4SS; pfam07996
1036172003942	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1036172003943	Helix-turn-helix domain; Region: HTH_36; pfam13730
1036172003944	Helix-turn-helix domain; Region: HTH_17; pfam12728
1036172003945	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
1036172003946	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
1036172003947	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1036172003948	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172003950	ATP binding site [chemical binding]; other site
1036172003951	Mg2+ binding site [ion binding]; other site
1036172003952	G-X-G motif; other site
1036172003953	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
1036172003954	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1036172003955	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1036172003956	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1036172003957	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1036172003958	DNA binding site [nucleotide binding]
1036172003959	substrate interaction site [chemical binding]; other site
1036172003960	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1036172003961	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1036172003962	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036172003963	active site
1036172003964	Int/Topo IB signature motif; other site
1036172003965	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1036172003966	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1036172003967	FRG domain; Region: FRG; pfam08867
1036172003968	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1036172003969	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1036172003970	active site
1036172003971	catalytic residues [active]
1036172003972	DNA binding site [nucleotide binding]
1036172003973	Int/Topo IB signature motif; other site
1036172003974	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
1036172003975	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
1036172003976	Rrf2 family protein; Region: rrf2_super; TIGR00738
1036172003977	Transcriptional regulator; Region: Rrf2; pfam02082
1036172003978	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
1036172003979	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1036172003980	Binuclear center (active site) [active]
1036172003981	K-pathway; other site
1036172003982	Putative proton exit pathway; other site
1036172003983	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1036172003984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036172003985	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1036172003986	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172003987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172003988	active site
1036172003989	phosphorylation site [posttranslational modification]
1036172003990	intermolecular recognition site; other site
1036172003991	dimerization interface [polypeptide binding]; other site
1036172003992	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1036172003993	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036172003994	PAS domain; Region: PAS_9; pfam13426
1036172003995	putative active site [active]
1036172003996	heme pocket [chemical binding]; other site
1036172003997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036172003998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172003999	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172004000	dimer interface [polypeptide binding]; other site
1036172004001	phosphorylation site [posttranslational modification]
1036172004002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004003	ATP binding site [chemical binding]; other site
1036172004004	Mg2+ binding site [ion binding]; other site
1036172004005	G-X-G motif; other site
1036172004006	chaperone protein DnaJ; Provisional; Region: PRK14299
1036172004007	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036172004008	HSP70 interaction site [polypeptide binding]; other site
1036172004009	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1036172004010	substrate binding site [polypeptide binding]; other site
1036172004011	dimer interface [polypeptide binding]; other site
1036172004012	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1036172004013	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036172004014	DNA binding residues [nucleotide binding]
1036172004015	putative dimer interface [polypeptide binding]; other site
1036172004016	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1036172004017	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172004018	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036172004019	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036172004020	Walker A/P-loop; other site
1036172004021	ATP binding site [chemical binding]; other site
1036172004022	Q-loop/lid; other site
1036172004023	ABC transporter signature motif; other site
1036172004024	Walker B; other site
1036172004025	D-loop; other site
1036172004026	H-loop/switch region; other site
1036172004027	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1036172004028	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036172004029	Walker A/P-loop; other site
1036172004030	ATP binding site [chemical binding]; other site
1036172004031	Q-loop/lid; other site
1036172004032	ABC transporter signature motif; other site
1036172004033	Walker B; other site
1036172004034	D-loop; other site
1036172004035	H-loop/switch region; other site
1036172004036	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1036172004037	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1036172004038	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1036172004039	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1036172004040	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1036172004041	hypothetical protein; Provisional; Region: PRK14013
1036172004042	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1036172004043	genetic element 3
1036172004044	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036172004045	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1036172004046	active site
1036172004047	Int/Topo IB signature motif; other site
1036172004048	DNA binding site [nucleotide binding]
1036172004049	AAA domain; Region: AAA_21; pfam13304
1036172004050	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172004051	ABC transporter signature motif; other site
1036172004052	Walker B; other site
1036172004053	D-loop; other site
1036172004054	H-loop/switch region; other site
1036172004055	HNH endonuclease; Region: HNH_2; pfam13391
1036172004056	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1036172004057	DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898
1036172004058	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1036172004059	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1036172004060	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172004061	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172004062	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1036172004063	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172004064	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172004065	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1036172004066	IMP binding site; other site
1036172004067	dimer interface [polypeptide binding]; other site
1036172004068	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036172004069	Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955
1036172004070	NodB motif; other site
1036172004071	putative active site [active]
1036172004072	putative catalytic site [active]
1036172004073	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
1036172004074	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
1036172004075	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1036172004076	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1036172004077	cell division protein FtsZ; Region: ftsZ; TIGR00065
1036172004078	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1036172004079	nucleotide binding site [chemical binding]; other site
1036172004080	SulA interaction site; other site
1036172004081	cell division protein FtsA; Region: ftsA; TIGR01174
1036172004082	Cell division protein FtsA; Region: FtsA; smart00842
1036172004083	Cell division protein FtsA; Region: FtsA; pfam14450
1036172004084	SurA N-terminal domain; Region: SurA_N_3; cl07813
1036172004085	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1036172004086	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1036172004087	AAA domain; Region: AAA_30; pfam13604
1036172004088	Family description; Region: UvrD_C_2; pfam13538
1036172004089	adenylosuccinate synthetase; Provisional; Region: PTZ00350
1036172004090	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1036172004091	ArsC family; Region: ArsC; pfam03960
1036172004092	catalytic residues [active]
1036172004093	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1036172004094	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1036172004095	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036172004096	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172004097	ABC transporter; Region: ABC_tran_2; pfam12848
1036172004098	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036172004099	Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171
1036172004100	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036172004101	putative trimer interface [polypeptide binding]; other site
1036172004102	putative CoA binding site [chemical binding]; other site
1036172004103	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1036172004104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172004105	motif II; other site
1036172004106	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1036172004107	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1036172004108	primosome assembly protein PriA; Validated; Region: PRK05580
1036172004109	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036172004110	ATP binding site [chemical binding]; other site
1036172004111	putative Mg++ binding site [ion binding]; other site
1036172004112	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1036172004113	ATP-binding site [chemical binding]; other site
1036172004114	proteasome-activating nucleotidase; Provisional; Region: PRK03992
1036172004115	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1036172004116	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1036172004117	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1036172004118	dimerization interface [polypeptide binding]; other site
1036172004119	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1036172004120	ATP binding site [chemical binding]; other site
1036172004121	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1036172004122	homodimer interface [polypeptide binding]; other site
1036172004123	chemical substrate binding site [chemical binding]; other site
1036172004124	oligomer interface [polypeptide binding]; other site
1036172004125	metal binding site [ion binding]; metal-binding site
1036172004126	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036172004127	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1036172004128	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1036172004129	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1036172004130	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
1036172004131	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1036172004132	G1 box; other site
1036172004133	GTP/Mg2+ binding site [chemical binding]; other site
1036172004134	G2 box; other site
1036172004135	Switch I region; other site
1036172004136	G3 box; other site
1036172004137	Switch II region; other site
1036172004138	G4 box; other site
1036172004139	G5 box; other site
1036172004140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172004141	dimer interface [polypeptide binding]; other site
1036172004142	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172004143	putative CheW interface [polypeptide binding]; other site
1036172004144	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036172004145	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036172004146	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036172004147	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1036172004148	active site flap/lid [active]
1036172004149	nucleophilic elbow; other site
1036172004150	catalytic triad [active]
1036172004151	flavoprotein, HI0933 family; Region: TIGR00275
1036172004152	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036172004153	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1036172004154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1036172004155	Amidase; Region: Amidase; cl11426
1036172004156	urea carboxylase; Region: urea_carbox; TIGR02712
1036172004157	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036172004158	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172004159	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1036172004160	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1036172004161	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1036172004162	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036172004163	carboxyltransferase (CT) interaction site; other site
1036172004164	biotinylation site [posttranslational modification]; other site
1036172004165	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1036172004166	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1036172004167	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1036172004168	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
1036172004169	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172004170	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036172004171	Walker A/P-loop; other site
1036172004172	ATP binding site [chemical binding]; other site
1036172004173	Q-loop/lid; other site
1036172004174	ABC transporter signature motif; other site
1036172004175	Walker B; other site
1036172004176	D-loop; other site
1036172004177	H-loop/switch region; other site
1036172004178	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036172004179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172004180	dimer interface [polypeptide binding]; other site
1036172004181	conserved gate region; other site
1036172004182	putative PBP binding loops; other site
1036172004183	ABC-ATPase subunit interface; other site
1036172004184	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1036172004185	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1036172004186	Protein of unknown function (DUF808); Region: DUF808; cl01002
1036172004187	Protein of unknown function, DUF481; Region: DUF481; pfam04338
1036172004188	integral membrane protein; Region: integ_memb_HG; TIGR03954
1036172004189	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1036172004190	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1036172004191	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1036172004192	Ligand Binding Site [chemical binding]; other site
1036172004193	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172004194	active site residue [active]
1036172004195	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
1036172004196	Acylphosphatase; Region: Acylphosphatase; pfam00708
1036172004197	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1036172004198	HypF finger; Region: zf-HYPF; pfam07503
1036172004199	HypF finger; Region: zf-HYPF; pfam07503
1036172004200	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1036172004201	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1036172004202	nickel binding site [ion binding]; other site
1036172004203	putative substrate-binding site; other site
1036172004204	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1036172004205	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1036172004206	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1036172004207	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
1036172004208	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1036172004209	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1036172004210	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1036172004211	putative substrate-binding site; other site
1036172004212	nickel binding site [ion binding]; other site
1036172004213	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1036172004214	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1036172004215	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1036172004216	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1036172004217	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1036172004218	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
1036172004219	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1036172004220	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1036172004221	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1036172004222	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1036172004223	substrate binding site [chemical binding]; other site
1036172004224	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
1036172004225	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1036172004226	substrate binding site [chemical binding]; other site
1036172004227	ligand binding site [chemical binding]; other site
1036172004228	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1036172004229	PAS fold; Region: PAS; pfam00989
1036172004230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172004231	putative active site [active]
1036172004232	heme pocket [chemical binding]; other site
1036172004233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172004234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172004235	metal binding site [ion binding]; metal-binding site
1036172004236	active site
1036172004237	I-site; other site
1036172004238	hypothetical protein; Provisional; Region: PRK12378
1036172004239	VacJ like lipoprotein; Region: VacJ; cl01073
1036172004240	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1036172004241	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1036172004242	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
1036172004243	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1036172004244	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1036172004245	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172004246	motif II; other site
1036172004247	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1036172004248	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036172004249	catalytic residues [active]
1036172004250	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1036172004251	Thioredoxin; Region: Thioredoxin_4; cl17273
1036172004252	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1036172004253	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
1036172004254	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1036172004255	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036172004256	active site
1036172004257	RNA polymerase sigma factor; Reviewed; Region: PRK12527
1036172004258	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036172004259	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1036172004260	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1036172004261	FecR protein; Region: FecR; pfam04773
1036172004262	Secretin and TonB N terminus short domain; Region: STN; smart00965
1036172004263	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1036172004264	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172004265	N-terminal plug; other site
1036172004266	ligand-binding site [chemical binding]; other site
1036172004267	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172004268	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172004269	metal binding site [ion binding]; metal-binding site
1036172004270	active site
1036172004271	I-site; other site
1036172004272	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1036172004273	diiron binding motif [ion binding]; other site
1036172004274	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
1036172004275	BCCT family transporter; Region: BCCT; pfam02028
1036172004276	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1036172004277	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1036172004278	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1036172004279	TrkA-N domain; Region: TrkA_N; pfam02254
1036172004280	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
1036172004281	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1036172004282	dimer interface [polypeptide binding]; other site
1036172004283	active site
1036172004284	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1036172004285	folate binding site [chemical binding]; other site
1036172004286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172004287	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172004288	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1036172004289	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1036172004290	DNA binding site [nucleotide binding]
1036172004291	active site
1036172004292	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1036172004293	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1036172004294	minor groove reading motif; other site
1036172004295	helix-hairpin-helix signature motif; other site
1036172004296	substrate binding pocket [chemical binding]; other site
1036172004297	active site
1036172004298	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
1036172004299	RNA/DNA hybrid binding site [nucleotide binding]; other site
1036172004300	active site
1036172004301	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
1036172004302	acetylornithine aminotransferase; Provisional; Region: PRK02627
1036172004303	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036172004304	inhibitor-cofactor binding pocket; inhibition site
1036172004305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172004306	catalytic residue [active]
1036172004307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1036172004308	MOSC domain; Region: MOSC; pfam03473
1036172004309	lipoyl synthase; Provisional; Region: PRK05481
1036172004310	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172004311	FeS/SAM binding site; other site
1036172004312	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1036172004313	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1036172004314	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1036172004315	dimer interface [polypeptide binding]; other site
1036172004316	TPP-binding site [chemical binding]; other site
1036172004317	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1036172004318	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036172004319	E3 interaction surface; other site
1036172004320	lipoyl attachment site [posttranslational modification]; other site
1036172004321	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036172004322	E3 interaction surface; other site
1036172004323	lipoyl attachment site [posttranslational modification]; other site
1036172004324	e3 binding domain; Region: E3_binding; pfam02817
1036172004325	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1036172004326	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1036172004327	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036172004328	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036172004329	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1036172004330	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1036172004331	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1036172004332	catalytic triad [active]
1036172004333	Secretin and TonB N terminus short domain; Region: STN; pfam07660
1036172004334	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1036172004335	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172004336	N-terminal plug; other site
1036172004337	ligand-binding site [chemical binding]; other site
1036172004338	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1036172004339	active site
1036172004340	catalytic residues [active]
1036172004341	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1036172004342	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1036172004343	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036172004344	ATP binding site [chemical binding]; other site
1036172004345	Mg++ binding site [ion binding]; other site
1036172004346	motif III; other site
1036172004347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172004348	nucleotide binding region [chemical binding]; other site
1036172004349	ATP-binding site [chemical binding]; other site
1036172004350	AAA domain; Region: AAA_21; pfam13304
1036172004351	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1036172004352	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1036172004353	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1036172004354	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036172004355	non-specific DNA binding site [nucleotide binding]; other site
1036172004356	salt bridge; other site
1036172004357	sequence-specific DNA binding site [nucleotide binding]; other site
1036172004358	uncharacterized domain; Region: TIGR00702
1036172004359	YcaO-like family; Region: YcaO; pfam02624
1036172004360	Domain of unknown function DUF302; Region: DUF302; cl01364
1036172004361	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
1036172004362	Nitrate and nitrite sensing; Region: NIT; pfam08376
1036172004363	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172004364	dimer interface [polypeptide binding]; other site
1036172004365	putative CheW interface [polypeptide binding]; other site
1036172004366	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
1036172004367	RNA/DNA hybrid binding site [nucleotide binding]; other site
1036172004368	active site
1036172004369	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
1036172004370	active site
1036172004371	catalytic residues [active]
1036172004372	metal binding site [ion binding]; metal-binding site
1036172004373	putative monooxygenase; Provisional; Region: PRK11118
1036172004374	Protein of unknown function, DUF417; Region: DUF417; cl01162
1036172004375	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1036172004376	DNA polymerase IV; Validated; Region: PRK01810
1036172004377	active site
1036172004378	DNA binding site [nucleotide binding]
1036172004379	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1036172004380	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1036172004381	dimer interface [polypeptide binding]; other site
1036172004382	putative functional site; other site
1036172004383	putative MPT binding site; other site
1036172004384	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036172004385	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1036172004386	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1036172004387	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1036172004388	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1036172004389	4Fe-4S binding domain; Region: Fer4; cl02805
1036172004390	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1036172004391	Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029
1036172004392	[4Fe-4S] binding site [ion binding]; other site
1036172004393	molybdopterin cofactor binding site; other site
1036172004394	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172004395	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1036172004396	molybdopterin cofactor binding site; other site
1036172004397	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
1036172004398	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1036172004399	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1036172004400	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1036172004401	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
1036172004402	putative ligand binding site [chemical binding]; other site
1036172004403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172004404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004405	ATP binding site [chemical binding]; other site
1036172004406	Mg2+ binding site [ion binding]; other site
1036172004407	G-X-G motif; other site
1036172004408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172004409	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172004410	active site
1036172004411	phosphorylation site [posttranslational modification]
1036172004412	intermolecular recognition site; other site
1036172004413	dimerization interface [polypeptide binding]; other site
1036172004414	Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732
1036172004415	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1036172004416	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036172004417	metal-binding site [ion binding]
1036172004418	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036172004419	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036172004420	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1036172004421	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1036172004422	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1036172004423	4Fe-4S binding domain; Region: Fer4; cl02805
1036172004424	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1036172004425	[4Fe-4S] binding site [ion binding]; other site
1036172004426	molybdopterin cofactor binding site; other site
1036172004427	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036172004428	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1036172004429	molybdopterin cofactor binding site; other site
1036172004430	selenophosphate synthetase; Provisional; Region: PRK00943
1036172004431	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1036172004432	dimerization interface [polypeptide binding]; other site
1036172004433	putative ATP binding site [chemical binding]; other site
1036172004434	TPR repeat; Region: TPR_11; pfam13414
1036172004435	Sel1-like repeats; Region: SEL1; smart00671
1036172004436	Sel1-like repeats; Region: SEL1; smart00671
1036172004437	selenocysteine synthase; Provisional; Region: PRK04311
1036172004438	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1036172004439	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
1036172004440	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1036172004441	G1 box; other site
1036172004442	putative GEF interaction site [polypeptide binding]; other site
1036172004443	GTP/Mg2+ binding site [chemical binding]; other site
1036172004444	Switch I region; other site
1036172004445	G2 box; other site
1036172004446	G3 box; other site
1036172004447	Switch II region; other site
1036172004448	G4 box; other site
1036172004449	G5 box; other site
1036172004450	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1036172004451	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
1036172004452	Arginosuccinate synthase; Region: Arginosuc_synth; cl17227
1036172004453	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1036172004454	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1036172004455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1036172004456	ATP binding site [chemical binding]; other site
1036172004457	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172004458	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172004459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172004460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172004461	dimer interface [polypeptide binding]; other site
1036172004462	phosphorylation site [posttranslational modification]
1036172004463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004464	ATP binding site [chemical binding]; other site
1036172004465	Mg2+ binding site [ion binding]; other site
1036172004466	G-X-G motif; other site
1036172004467	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036172004468	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036172004469	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1036172004470	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1036172004471	putative active site [active]
1036172004472	PhoH-like protein; Region: PhoH; cl17668
1036172004473	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1036172004474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172004475	PAS domain; Region: PAS_9; pfam13426
1036172004476	putative active site [active]
1036172004477	heme pocket [chemical binding]; other site
1036172004478	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172004479	metal binding site [ion binding]; metal-binding site
1036172004480	active site
1036172004481	I-site; other site
1036172004482	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172004483	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1036172004484	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1036172004485	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1036172004486	GAF domain; Region: GAF_2; pfam13185
1036172004487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172004488	PAS domain; Region: PAS_9; pfam13426
1036172004489	putative active site [active]
1036172004490	heme pocket [chemical binding]; other site
1036172004491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172004492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172004493	metal binding site [ion binding]; metal-binding site
1036172004494	active site
1036172004495	I-site; other site
1036172004496	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1036172004497	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036172004498	ATP binding site [chemical binding]; other site
1036172004499	Mg++ binding site [ion binding]; other site
1036172004500	motif III; other site
1036172004501	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172004502	nucleotide binding region [chemical binding]; other site
1036172004503	ATP-binding site [chemical binding]; other site
1036172004504	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1036172004505	putative RNA binding site [nucleotide binding]; other site
1036172004506	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036172004507	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036172004508	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
1036172004509	heat shock protein 90; Provisional; Region: PRK05218
1036172004510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004511	ATP binding site [chemical binding]; other site
1036172004512	Mg2+ binding site [ion binding]; other site
1036172004513	G-X-G motif; other site
1036172004514	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1036172004515	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1036172004516	dimer interface [polypeptide binding]; other site
1036172004517	active site
1036172004518	heme binding site [chemical binding]; other site
1036172004519	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1036172004520	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172004521	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172004522	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172004523	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1036172004524	mce related protein; Region: MCE; pfam02470
1036172004525	mce related protein; Region: MCE; pfam02470
1036172004526	mce related protein; Region: MCE; pfam02470
1036172004527	mce related protein; Region: MCE; pfam02470
1036172004528	Paraquat-inducible protein A; Region: PqiA; pfam04403
1036172004529	Paraquat-inducible protein A; Region: PqiA; pfam04403
1036172004530	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1036172004531	heme-binding site [chemical binding]; other site
1036172004532	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172004533	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172004534	metal binding site [ion binding]; metal-binding site
1036172004535	active site
1036172004536	I-site; other site
1036172004537	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172004538	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1036172004539	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036172004540	EamA-like transporter family; Region: EamA; pfam00892
1036172004541	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1036172004542	putative deacylase active site [active]
1036172004543	YceI-like domain; Region: YceI; cl01001
1036172004544	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1036172004545	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1036172004546	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1036172004547	conserved cys residue [active]
1036172004548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172004549	S-adenosylmethionine binding site [chemical binding]; other site
1036172004550	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1036172004551	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172004552	N-terminal plug; other site
1036172004553	ligand-binding site [chemical binding]; other site
1036172004554	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1036172004555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036172004556	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036172004557	DNA binding residues [nucleotide binding]
1036172004558	agmatinase; Region: agmatinase; TIGR01230
1036172004559	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1036172004560	putative active site [active]
1036172004561	Mn binding site [ion binding]; other site
1036172004562	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1036172004563	isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090
1036172004564	active site
1036172004565	catalytic residues [active]
1036172004566	metal binding site [ion binding]; metal-binding site
1036172004567	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1036172004568	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036172004569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036172004570	Mg2+ binding site [ion binding]; other site
1036172004571	G-X-G motif; other site
1036172004572	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172004573	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172004574	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172004575	N-terminal plug; other site
1036172004576	ligand-binding site [chemical binding]; other site
1036172004577	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1036172004578	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1036172004579	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1036172004580	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1036172004581	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1036172004582	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1036172004583	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1036172004584	DHHA2 domain; Region: DHHA2; pfam02833
1036172004585	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1036172004586	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
1036172004587	active site
1036172004588	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1036172004589	Aspartase; Region: Aspartase; cd01357
1036172004590	active sites [active]
1036172004591	tetramer interface [polypeptide binding]; other site
1036172004592	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1036172004593	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1036172004594	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1036172004595	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1036172004596	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1036172004597	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1036172004598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036172004599	binding surface
1036172004600	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1036172004601	TPR motif; other site
1036172004602	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172004603	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172004604	ligand binding site [chemical binding]; other site
1036172004605	translocation protein TolB; Provisional; Region: tolB; PRK04043
1036172004606	TonB C terminal; Region: TonB_2; pfam13103
1036172004607	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1036172004608	TolR protein; Region: tolR; TIGR02801
1036172004609	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1036172004610	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
1036172004611	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1036172004612	gamma subunit interface [polypeptide binding]; other site
1036172004613	epsilon subunit interface [polypeptide binding]; other site
1036172004614	LBP interface [polypeptide binding]; other site
1036172004615	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1036172004616	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1036172004617	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1036172004618	alpha subunit interaction interface [polypeptide binding]; other site
1036172004619	Walker A motif; other site
1036172004620	ATP binding site [chemical binding]; other site
1036172004621	Walker B motif; other site
1036172004622	inhibitor binding site; inhibition site
1036172004623	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1036172004624	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1036172004625	core domain interface [polypeptide binding]; other site
1036172004626	delta subunit interface [polypeptide binding]; other site
1036172004627	epsilon subunit interface [polypeptide binding]; other site
1036172004628	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1036172004629	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1036172004630	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1036172004631	beta subunit interaction interface [polypeptide binding]; other site
1036172004632	Walker A motif; other site
1036172004633	ATP binding site [chemical binding]; other site
1036172004634	Walker B motif; other site
1036172004635	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1036172004636	F0F1 ATP synthase subunit delta; Validated; Region: PRK08474
1036172004637	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1036172004638	F0F1 ATP synthase subunit B; Validated; Region: PRK08475
1036172004639	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
1036172004640	F0F1 ATP synthase subunit B'; Validated; Region: PRK08476
1036172004641	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1036172004642	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1036172004643	ParB-like nuclease domain; Region: ParB; smart00470
1036172004644	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1036172004645	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036172004646	P-loop; other site
1036172004647	Magnesium ion binding site [ion binding]; other site
1036172004648	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036172004649	Magnesium ion binding site [ion binding]; other site
1036172004650	biotin--protein ligase; Provisional; Region: PRK08477
1036172004651	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1036172004652	Predicted permeases [General function prediction only]; Region: COG0679
1036172004653	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1036172004654	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1036172004655	putative active site [active]
1036172004656	substrate binding site [chemical binding]; other site
1036172004657	putative cosubstrate binding site; other site
1036172004658	catalytic site [active]
1036172004659	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1036172004660	substrate binding site [chemical binding]; other site
1036172004661	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1036172004662	nucleotide binding site [chemical binding]; other site
1036172004663	homotetrameric interface [polypeptide binding]; other site
1036172004664	putative phosphate binding site [ion binding]; other site
1036172004665	putative allosteric binding site; other site
1036172004666	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1036172004667	GTP1/OBG; Region: GTP1_OBG; pfam01018
1036172004668	Obg GTPase; Region: Obg; cd01898
1036172004669	G1 box; other site
1036172004670	GTP/Mg2+ binding site [chemical binding]; other site
1036172004671	Switch I region; other site
1036172004672	G2 box; other site
1036172004673	G3 box; other site
1036172004674	Switch II region; other site
1036172004675	G4 box; other site
1036172004676	G5 box; other site
1036172004677	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1036172004678	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
1036172004679	DNA primase; Validated; Region: dnaG; PRK05667
1036172004680	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1036172004681	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1036172004682	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1036172004683	active site
1036172004684	metal binding site [ion binding]; metal-binding site
1036172004685	interdomain interaction site; other site
1036172004686	ribonuclease III; Reviewed; Region: rnc; PRK00102
1036172004687	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1036172004688	dimerization interface [polypeptide binding]; other site
1036172004689	active site
1036172004690	metal binding site [ion binding]; metal-binding site
1036172004691	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1036172004692	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1036172004693	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1036172004694	Tetramer interface [polypeptide binding]; other site
1036172004695	active site
1036172004696	FMN-binding site [chemical binding]; other site
1036172004697	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1036172004698	M48 family peptidase; Provisional; Region: PRK03001
1036172004699	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
1036172004700	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036172004701	catalytic core [active]
1036172004702	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1036172004703	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1036172004704	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1036172004705	G1 box; other site
1036172004706	GTP/Mg2+ binding site [chemical binding]; other site
1036172004707	Switch I region; other site
1036172004708	G2 box; other site
1036172004709	Switch II region; other site
1036172004710	G3 box; other site
1036172004711	G4 box; other site
1036172004712	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1036172004713	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1036172004714	membrane protein insertase; Provisional; Region: PRK01318
1036172004715	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1036172004716	Haemolytic domain; Region: Haemolytic; pfam01809
1036172004717	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1036172004718	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1036172004719	Clp amino terminal domain; Region: Clp_N; pfam02861
1036172004720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172004721	Walker A motif; other site
1036172004722	ATP binding site [chemical binding]; other site
1036172004723	Walker B motif; other site
1036172004724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172004725	Walker A motif; other site
1036172004726	ATP binding site [chemical binding]; other site
1036172004727	Walker B motif; other site
1036172004728	arginine finger; other site
1036172004729	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1036172004730	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1036172004731	RNA/DNA hybrid binding site [nucleotide binding]; other site
1036172004732	active site
1036172004733	Domain of unknown function DUF77; Region: DUF77; cl00307
1036172004734	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1036172004735	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1036172004736	methionine sulfoxide reductase B; Provisional; Region: PRK05508
1036172004737	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1036172004738	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1036172004739	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1036172004740	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1036172004741	putative active site [active]
1036172004742	putative CoA binding site [chemical binding]; other site
1036172004743	nudix motif; other site
1036172004744	metal binding site [ion binding]; metal-binding site
1036172004745	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036172004746	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1036172004747	inhibitor-cofactor binding pocket; inhibition site
1036172004748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172004749	catalytic residue [active]
1036172004750	NMT1/THI5 like; Region: NMT1; pfam09084
1036172004751	ATP phosphoribosyltransferase; Region: HisG; cl15266
1036172004752	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036172004753	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036172004754	substrate binding pocket [chemical binding]; other site
1036172004755	membrane-bound complex binding site; other site
1036172004756	hinge residues; other site
1036172004757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172004758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004759	ATP binding site [chemical binding]; other site
1036172004760	Mg2+ binding site [ion binding]; other site
1036172004761	G-X-G motif; other site
1036172004762	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1036172004763	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1036172004764	purine monophosphate binding site [chemical binding]; other site
1036172004765	dimer interface [polypeptide binding]; other site
1036172004766	putative catalytic residues [active]
1036172004767	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1036172004768	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1036172004769	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1036172004770	dimerization interface [polypeptide binding]; other site
1036172004771	ATP binding site [chemical binding]; other site
1036172004772	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1036172004773	dimerization interface [polypeptide binding]; other site
1036172004774	ATP binding site [chemical binding]; other site
1036172004775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1036172004776	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1036172004777	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036172004778	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036172004779	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1036172004780	homodecamer interface [polypeptide binding]; other site
1036172004781	GTP cyclohydrolase I; Provisional; Region: PLN03044
1036172004782	active site
1036172004783	putative catalytic site residues [active]
1036172004784	zinc binding site [ion binding]; other site
1036172004785	GTP-CH-I/GFRP interaction surface; other site
1036172004786	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1036172004787	Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836
1036172004788	Cl binding site [ion binding]; other site
1036172004789	oligomer interface [polypeptide binding]; other site
1036172004790	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1036172004791	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1036172004792	Type II/IV secretion system protein; Region: T2SE; pfam00437
1036172004793	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036172004794	Walker A motif; other site
1036172004795	ATP binding site [chemical binding]; other site
1036172004796	Walker B motif; other site
1036172004797	GTPase Era; Reviewed; Region: era; PRK00089
1036172004798	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1036172004799	G1 box; other site
1036172004800	GTP/Mg2+ binding site [chemical binding]; other site
1036172004801	Switch I region; other site
1036172004802	G2 box; other site
1036172004803	Switch II region; other site
1036172004804	G3 box; other site
1036172004805	G4 box; other site
1036172004806	G5 box; other site
1036172004807	KH domain; Region: KH_2; pfam07650
1036172004808	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1036172004809	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1036172004810	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1036172004811	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1036172004812	Cache domain; Region: Cache_2; cl07034
1036172004813	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172004814	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172004815	dimer interface [polypeptide binding]; other site
1036172004816	putative CheW interface [polypeptide binding]; other site
1036172004817	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172004818	PAS domain; Region: PAS_9; pfam13426
1036172004819	putative active site [active]
1036172004820	heme pocket [chemical binding]; other site
1036172004821	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
1036172004822	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1036172004823	active site
1036172004824	catalytic residues [active]
1036172004825	metal binding site [ion binding]; metal-binding site
1036172004826	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1036172004827	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1036172004828	oligomer interface [polypeptide binding]; other site
1036172004829	active site residues [active]
1036172004830	trigger factor; Provisional; Region: tig; PRK01490
1036172004831	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1036172004832	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1036172004833	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1036172004834	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1036172004835	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1036172004836	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1036172004837	dimer interface [polypeptide binding]; other site
1036172004838	active site
1036172004839	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036172004840	catalytic residues [active]
1036172004841	substrate binding site [chemical binding]; other site
1036172004842	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1036172004843	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1036172004844	NAD(P) binding pocket [chemical binding]; other site
1036172004845	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1036172004846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1036172004847	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1036172004848	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1036172004849	homodimer interface [polypeptide binding]; other site
1036172004850	substrate-cofactor binding pocket; other site
1036172004851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172004852	catalytic residue [active]
1036172004853	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036172004854	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1036172004855	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172004856	catalytic residue [active]
1036172004857	Predicted permeases [General function prediction only]; Region: COG0679
1036172004858	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1036172004859	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036172004860	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1036172004861	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036172004862	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036172004863	catalytic residues [active]
1036172004864	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1036172004865	Cytochrome c; Region: Cytochrom_C; cl11414
1036172004866	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1036172004867	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172004868	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172004869	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036172004870	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036172004871	Coenzyme A binding pocket [chemical binding]; other site
1036172004872	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
1036172004873	High-affinity nickel-transport protein; Region: NicO; cl00964
1036172004874	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
1036172004875	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1036172004876	putative metal binding residues [ion binding]; other site
1036172004877	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036172004878	metal binding site 2 [ion binding]; metal-binding site
1036172004879	putative DNA binding helix; other site
1036172004880	metal binding site 1 [ion binding]; metal-binding site
1036172004881	dimer interface [polypeptide binding]; other site
1036172004882	structural Zn2+ binding site [ion binding]; other site
1036172004883	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
1036172004884	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1036172004885	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1036172004886	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1036172004887	Imelysin; Region: Peptidase_M75; pfam09375
1036172004888	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
1036172004889	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1036172004890	Imelysin; Region: Peptidase_M75; cl09159
1036172004891	F0F1 ATP synthase subunit C; Validated; Region: PRK08482
1036172004892	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1036172004893	dimer interface [polypeptide binding]; other site
1036172004894	substrate binding site [chemical binding]; other site
1036172004895	ATP binding site [chemical binding]; other site
1036172004896	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1036172004897	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1036172004898	putative catalytic cysteine [active]
1036172004899	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
1036172004900	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
1036172004901	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1036172004902	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1036172004903	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1036172004904	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036172004905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172004906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1036172004907	dimer interface [polypeptide binding]; other site
1036172004908	phosphorylation site [posttranslational modification]
1036172004909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172004910	ATP binding site [chemical binding]; other site
1036172004911	Mg2+ binding site [ion binding]; other site
1036172004912	G-X-G motif; other site
1036172004913	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172004914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172004915	active site
1036172004916	phosphorylation site [posttranslational modification]
1036172004917	intermolecular recognition site; other site
1036172004918	dimerization interface [polypeptide binding]; other site
1036172004919	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172004920	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1036172004921	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1036172004922	DNA binding site [nucleotide binding]
1036172004923	active site
1036172004924	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1036172004925	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1036172004926	active site
1036172004927	substrate binding site [chemical binding]; other site
1036172004928	metal binding site [ion binding]; metal-binding site
1036172004929	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1036172004930	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1036172004931	active site
1036172004932	catalytic triad [active]
1036172004933	dimer interface [polypeptide binding]; other site
1036172004934	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1036172004935	catalytic residue [active]
1036172004936	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
1036172004937	flavodoxin FldA; Validated; Region: PRK09267
1036172004938	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036172004939	metal binding site 2 [ion binding]; metal-binding site
1036172004940	putative DNA binding helix; other site
1036172004941	metal binding site 1 [ion binding]; metal-binding site
1036172004942	dimer interface [polypeptide binding]; other site
1036172004943	structural Zn2+ binding site [ion binding]; other site
1036172004944	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1036172004945	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1036172004946	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1036172004947	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1036172004948	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1036172004949	substrate binding site [chemical binding]; other site
1036172004950	active site
1036172004951	catalytic residues [active]
1036172004952	heterodimer interface [polypeptide binding]; other site
1036172004953	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1036172004954	active site
1036172004955	oligomerization interface [polypeptide binding]; other site
1036172004956	metal binding site [ion binding]; metal-binding site
1036172004957	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1036172004958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172004959	Walker A motif; other site
1036172004960	ATP binding site [chemical binding]; other site
1036172004961	Walker B motif; other site
1036172004962	arginine finger; other site
1036172004963	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1036172004964	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1036172004965	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036172004966	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
1036172004967	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172004968	active site residue [active]
1036172004969	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
1036172004970	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172004971	FeS/SAM binding site; other site
1036172004972	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1036172004973	substrate binding site [chemical binding]; other site
1036172004974	active site
1036172004975	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
1036172004976	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1036172004977	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036172004978	DNA gyrase subunit A; Validated; Region: PRK05560
1036172004979	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1036172004980	CAP-like domain; other site
1036172004981	active site
1036172004982	primary dimer interface [polypeptide binding]; other site
1036172004983	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004984	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004985	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004986	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004987	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004988	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036172004989	Protein of unknown function (DUF465); Region: DUF465; cl01070
1036172004990	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1036172004991	heterotetramer interface [polypeptide binding]; other site
1036172004992	active site pocket [active]
1036172004993	cleavage site
1036172004994	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1036172004995	TrkA-N domain; Region: TrkA_N; pfam02254
1036172004996	TrkA-C domain; Region: TrkA_C; pfam02080
1036172004997	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1036172004998	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036172004999	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
1036172005000	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1036172005001	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036172005002	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1036172005003	NAD(P) binding site [chemical binding]; other site
1036172005004	active site
1036172005005	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1036172005006	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1036172005007	putative ribose interaction site [chemical binding]; other site
1036172005008	putative ADP binding site [chemical binding]; other site
1036172005009	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1036172005010	active site
1036172005011	nucleotide binding site [chemical binding]; other site
1036172005012	HIGH motif; other site
1036172005013	KMSKS motif; other site
1036172005014	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1036172005015	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1036172005016	dimer interface [polypeptide binding]; other site
1036172005017	active site
1036172005018	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172005019	MULE transposase domain; Region: MULE; pfam10551
1036172005020	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1036172005021	Sulfatase; Region: Sulfatase; pfam00884
1036172005022	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1036172005023	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1036172005024	putative active site [active]
1036172005025	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
1036172005026	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
1036172005027	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1036172005028	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1036172005029	putative active site [active]
1036172005030	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1036172005031	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036172005032	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036172005033	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
1036172005034	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1036172005035	putative metal binding site; other site
1036172005036	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1036172005037	ligand binding site; other site
1036172005038	tetramer interface; other site
1036172005039	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
1036172005040	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1036172005041	active site
1036172005042	homodimer interface [polypeptide binding]; other site
1036172005043	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
1036172005044	NeuB family; Region: NeuB; pfam03102
1036172005045	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1036172005046	NeuB binding interface [polypeptide binding]; other site
1036172005047	putative substrate binding site [chemical binding]; other site
1036172005048	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1036172005049	O-Antigen ligase; Region: Wzy_C; pfam04932
1036172005050	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036172005051	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036172005052	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1036172005053	Sulfatase; Region: Sulfatase; cl17466
1036172005054	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1036172005055	serine/threonine protein kinase; Provisional; Region: PRK14879
1036172005056	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1036172005057	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1036172005058	putative acyl-acceptor binding pocket; other site
1036172005059	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1036172005060	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1036172005061	putative active site [active]
1036172005062	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1036172005063	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036172005064	nucleotide binding site [chemical binding]; other site
1036172005065	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1036172005066	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1036172005067	active site
1036172005068	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1036172005069	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036172005070	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036172005071	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1036172005072	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1036172005073	active site
1036172005074	dimer interface [polypeptide binding]; other site
1036172005075	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1036172005076	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1036172005077	active site
1036172005078	FMN binding site [chemical binding]; other site
1036172005079	substrate binding site [chemical binding]; other site
1036172005080	3Fe-4S cluster binding site [ion binding]; other site
1036172005081	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
1036172005082	domain_subunit interface; other site
1036172005083	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
1036172005084	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1036172005085	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172005086	dimer interface [polypeptide binding]; other site
1036172005087	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036172005088	putative CheW interface [polypeptide binding]; other site
1036172005089	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1036172005090	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1036172005091	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1036172005092	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1036172005093	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1036172005094	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1036172005095	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1036172005096	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036172005097	RNA binding surface [nucleotide binding]; other site
1036172005098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172005099	S-adenosylmethionine binding site [chemical binding]; other site
1036172005100	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1036172005101	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036172005102	active site
1036172005103	nucleotide binding site [chemical binding]; other site
1036172005104	HIGH motif; other site
1036172005105	KMSKS motif; other site
1036172005106	Riboflavin kinase; Region: Flavokinase; pfam01687
1036172005107	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036172005108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172005109	S-adenosylmethionine binding site [chemical binding]; other site
1036172005110	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1036172005111	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1036172005112	catalytic triad [active]
1036172005113	FAD binding domain; Region: FAD_binding_4; pfam01565
1036172005114	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1036172005115	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1036172005116	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1036172005117	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1036172005118	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1036172005119	hinge; other site
1036172005120	active site
1036172005121	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036172005122	EamA-like transporter family; Region: EamA; pfam00892
1036172005123	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1036172005124	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1036172005125	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172005126	Sel1 repeat; Region: Sel1; cl02723
1036172005127	Sel1-like repeats; Region: SEL1; smart00671
1036172005128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1036172005129	binding surface
1036172005130	TPR motif; other site
1036172005131	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1036172005132	homopentamer interface [polypeptide binding]; other site
1036172005133	active site
1036172005134	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1036172005135	putative RNA binding site [nucleotide binding]; other site
1036172005136	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1036172005137	active site
1036172005138	dimer interface [polypeptide binding]; other site
1036172005139	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036172005140	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036172005141	Walker A/P-loop; other site
1036172005142	ATP binding site [chemical binding]; other site
1036172005143	Q-loop/lid; other site
1036172005144	ABC transporter signature motif; other site
1036172005145	Walker B; other site
1036172005146	D-loop; other site
1036172005147	H-loop/switch region; other site
1036172005148	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1036172005149	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1036172005150	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1036172005151	G1 box; other site
1036172005152	GTP/Mg2+ binding site [chemical binding]; other site
1036172005153	Switch I region; other site
1036172005154	G2 box; other site
1036172005155	G3 box; other site
1036172005156	Switch II region; other site
1036172005157	G4 box; other site
1036172005158	G5 box; other site
1036172005159	Nucleoside recognition; Region: Gate; pfam07670
1036172005160	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1036172005161	Nucleoside recognition; Region: Gate; pfam07670
1036172005162	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1036172005163	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1036172005164	Heavy-metal-associated domain; Region: HMA; pfam00403
1036172005165	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036172005166	metal-binding site [ion binding]
1036172005167	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036172005168	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1036172005169	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036172005170	dimerization interface [polypeptide binding]; other site
1036172005171	putative DNA binding site [nucleotide binding]; other site
1036172005172	putative Zn2+ binding site [ion binding]; other site
1036172005173	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1036172005174	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172005175	N-terminal plug; other site
1036172005176	ligand-binding site [chemical binding]; other site
1036172005177	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1036172005178	Protein export membrane protein; Region: SecD_SecF; cl14618
1036172005179	Protein export membrane protein; Region: SecD_SecF; cl14618
1036172005180	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036172005181	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172005182	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1036172005183	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036172005184	DNA-binding site [nucleotide binding]; DNA binding site
1036172005185	RNA-binding motif; other site
1036172005186	Response regulator receiver domain; Region: Response_reg; pfam00072
1036172005187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172005188	active site
1036172005189	phosphorylation site [posttranslational modification]
1036172005190	intermolecular recognition site; other site
1036172005191	dimerization interface [polypeptide binding]; other site
1036172005192	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1036172005193	DNA binding site [nucleotide binding]
1036172005194	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036172005195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172005196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172005197	ATP binding site [chemical binding]; other site
1036172005198	Mg2+ binding site [ion binding]; other site
1036172005199	G-X-G motif; other site
1036172005200	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1036172005201	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1036172005202	dimer interface [polypeptide binding]; other site
1036172005203	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1036172005204	catalytic triad [active]
1036172005205	peroxidatic and resolving cysteines [active]
1036172005206	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036172005207	catalytic residues [active]
1036172005208	YCII-related domain; Region: YCII; cl00999
1036172005209	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1036172005210	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1036172005211	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1036172005212	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1036172005213	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1036172005214	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1036172005215	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1036172005216	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1036172005217	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1036172005218	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
1036172005219	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1036172005220	DNA binding site [nucleotide binding]
1036172005221	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1036172005222	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1036172005223	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1036172005224	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1036172005225	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1036172005226	RPB3 interaction site [polypeptide binding]; other site
1036172005227	RPB1 interaction site [polypeptide binding]; other site
1036172005228	RPB11 interaction site [polypeptide binding]; other site
1036172005229	RPB10 interaction site [polypeptide binding]; other site
1036172005230	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1036172005231	L11 interface [polypeptide binding]; other site
1036172005232	putative EF-Tu interaction site [polypeptide binding]; other site
1036172005233	putative EF-G interaction site [polypeptide binding]; other site
1036172005234	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1036172005235	23S rRNA interface [nucleotide binding]; other site
1036172005236	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1036172005237	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1036172005238	mRNA/rRNA interface [nucleotide binding]; other site
1036172005239	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1036172005240	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1036172005241	23S rRNA interface [nucleotide binding]; other site
1036172005242	L7/L12 interface [polypeptide binding]; other site
1036172005243	putative thiostrepton binding site; other site
1036172005244	L25 interface [polypeptide binding]; other site
1036172005245	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1036172005246	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1036172005247	putative homodimer interface [polypeptide binding]; other site
1036172005248	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1036172005249	heterodimer interface [polypeptide binding]; other site
1036172005250	homodimer interface [polypeptide binding]; other site
1036172005251	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1036172005252	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1036172005253	elongation factor Tu; Reviewed; Region: PRK00049
1036172005254	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1036172005255	G1 box; other site
1036172005256	GEF interaction site [polypeptide binding]; other site
1036172005257	GTP/Mg2+ binding site [chemical binding]; other site
1036172005258	Switch I region; other site
1036172005259	G2 box; other site
1036172005260	G3 box; other site
1036172005261	Switch II region; other site
1036172005262	G4 box; other site
1036172005263	G5 box; other site
1036172005264	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1036172005265	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1036172005266	Antibiotic Binding Site [chemical binding]; other site
1036172005267	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815
1036172005268	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036172005269	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1036172005270	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1036172005271	Mg++ binding site [ion binding]; other site
1036172005272	putative catalytic motif [active]
1036172005273	putative substrate binding site [chemical binding]; other site
1036172005274	phosphoglyceromutase; Provisional; Region: PRK05434
1036172005275	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
1036172005276	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1036172005277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172005278	Walker A/P-loop; other site
1036172005279	ATP binding site [chemical binding]; other site
1036172005280	Q-loop/lid; other site
1036172005281	ABC transporter signature motif; other site
1036172005282	Walker B; other site
1036172005283	D-loop; other site
1036172005284	H-loop/switch region; other site
1036172005285	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036172005286	Transglycosylase; Region: Transgly; pfam00912
1036172005287	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1036172005288	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1036172005289	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1036172005290	glutamine synthetase, type I; Region: GlnA; TIGR00653
1036172005291	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1036172005292	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1036172005293	histidinol-phosphatase; Provisional; Region: PRK07328
1036172005294	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1036172005295	active site
1036172005296	dimer interface [polypeptide binding]; other site
1036172005297	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1036172005298	MoaE homodimer interface [polypeptide binding]; other site
1036172005299	MoaD interaction [polypeptide binding]; other site
1036172005300	active site residues [active]
1036172005301	charged pocket; other site
1036172005302	ThiS family; Region: ThiS; pfam02597
1036172005303	hydrophobic patch; other site
1036172005304	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
1036172005305	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1036172005306	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1036172005307	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1036172005308	active site
1036172005309	homodimer interface [polypeptide binding]; other site
1036172005310	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1036172005311	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1036172005312	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036172005313	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036172005314	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1036172005315	active site
1036172005316	Cytochrome c; Region: Cytochrom_C; cl11414
1036172005317	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1036172005318	Clp amino terminal domain; Region: Clp_N; pfam02861
1036172005319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172005320	Walker A motif; other site
1036172005321	ATP binding site [chemical binding]; other site
1036172005322	Walker B motif; other site
1036172005323	arginine finger; other site
1036172005324	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025
1036172005325	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
1036172005326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172005327	Walker A motif; other site
1036172005328	ATP binding site [chemical binding]; other site
1036172005329	Walker B motif; other site
1036172005330	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1036172005331	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1036172005332	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1036172005333	AAA domain; Region: AAA_26; pfam13500
1036172005334	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1036172005335	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036172005336	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1036172005337	acyl-activating enzyme (AAE) consensus motif; other site
1036172005338	AMP binding site [chemical binding]; other site
1036172005339	active site
1036172005340	CoA binding site [chemical binding]; other site
1036172005341	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1036172005342	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1036172005343	putative active site [active]
1036172005344	putative catalytic site [active]
1036172005345	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1036172005346	putative active site [active]
1036172005347	putative catalytic site [active]
1036172005348	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1036172005349	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1036172005350	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1036172005351	Nitrate and nitrite sensing; Region: NIT; pfam08376
1036172005352	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172005353	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172005354	dimer interface [polypeptide binding]; other site
1036172005355	putative CheW interface [polypeptide binding]; other site
1036172005356	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1036172005357	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1036172005358	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1036172005359	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1036172005360	arsenical pump membrane protein; Provisional; Region: PRK15445
1036172005361	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1036172005362	transmembrane helices; other site
1036172005363	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036172005364	putative DNA binding site [nucleotide binding]; other site
1036172005365	dimerization interface [polypeptide binding]; other site
1036172005366	putative Zn2+ binding site [ion binding]; other site
1036172005367	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
1036172005368	Predicted permeases [General function prediction only]; Region: COG0701
1036172005369	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1036172005370	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1036172005371	Chromate transporter; Region: Chromate_transp; pfam02417
1036172005372	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1036172005373	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1036172005374	active site
1036172005375	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1036172005376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172005377	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036172005378	putative substrate translocation pore; other site
1036172005379	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1036172005380	FHIPEP family; Region: FHIPEP; pfam00771
1036172005381	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
1036172005382	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472
1036172005383	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1036172005384	Walker A motif/ATP binding site; other site
1036172005385	Walker B motif; other site
1036172005386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1036172005387	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1036172005388	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1036172005389	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1036172005390	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
1036172005391	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1036172005392	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1036172005393	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036172005394	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172005395	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
1036172005396	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1036172005397	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036172005398	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036172005399	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1036172005400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036172005401	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
1036172005402	flagellar motor switch protein FliY; Validated; Region: PRK08432
1036172005403	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1036172005404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036172005405	binding surface
1036172005406	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1036172005407	TPR motif; other site
1036172005408	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
1036172005409	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
1036172005410	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036172005411	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172005412	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
1036172005413	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172005414	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1036172005415	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1036172005416	Flagellar assembly protein FliH; Region: FliH; pfam02108
1036172005417	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1036172005418	MgtE intracellular N domain; Region: MgtE_N; cl15244
1036172005419	FliG C-terminal domain; Region: FliG_C; pfam01706
1036172005420	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1036172005421	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1036172005422	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1036172005423	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1036172005424	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1036172005425	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1036172005426	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172005427	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1036172005428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172005429	active site
1036172005430	phosphorylation site [posttranslational modification]
1036172005431	intermolecular recognition site; other site
1036172005432	dimerization interface [polypeptide binding]; other site
1036172005433	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1036172005434	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036172005435	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036172005436	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
1036172005437	RimM N-terminal domain; Region: RimM; pfam01782
1036172005438	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1036172005439	KH domain; Region: KH_4; pfam13083
1036172005440	G-X-X-G motif; other site
1036172005441	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1036172005442	signal recognition particle protein; Provisional; Region: PRK10867
1036172005443	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1036172005444	P loop; other site
1036172005445	GTP binding site [chemical binding]; other site
1036172005446	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1036172005447	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036172005448	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036172005449	active site
1036172005450	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1036172005451	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1036172005452	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1036172005453	Putative zinc ribbon domain; Region: DUF164; pfam02591
1036172005454	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1036172005455	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1036172005456	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1036172005457	dimer interface [polypeptide binding]; other site
1036172005458	motif 1; other site
1036172005459	active site
1036172005460	motif 2; other site
1036172005461	motif 3; other site
1036172005462	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1036172005463	catalytic residues [active]
1036172005464	AIR carboxylase; Region: AIRC; smart01001
1036172005465	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1036172005466	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1036172005467	Peptidase family U32; Region: Peptidase_U32; pfam01136
1036172005468	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1036172005469	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036172005470	dimerization interface [polypeptide binding]; other site
1036172005471	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036172005472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172005473	dimer interface [polypeptide binding]; other site
1036172005474	putative CheW interface [polypeptide binding]; other site
1036172005475	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1036172005476	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1036172005477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172005478	Walker A/P-loop; other site
1036172005479	ATP binding site [chemical binding]; other site
1036172005480	Q-loop/lid; other site
1036172005481	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1036172005482	ABC transporter signature motif; other site
1036172005483	Walker B; other site
1036172005484	D-loop; other site
1036172005485	H-loop/switch region; other site
1036172005486	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1036172005487	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1036172005488	elongation factor G; Reviewed; Region: PRK00007
1036172005489	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1036172005490	G1 box; other site
1036172005491	putative GEF interaction site [polypeptide binding]; other site
1036172005492	GTP/Mg2+ binding site [chemical binding]; other site
1036172005493	Switch I region; other site
1036172005494	G2 box; other site
1036172005495	G3 box; other site
1036172005496	Switch II region; other site
1036172005497	G4 box; other site
1036172005498	G5 box; other site
1036172005499	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1036172005500	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1036172005501	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1036172005502	30S ribosomal protein S7; Validated; Region: PRK05302
1036172005503	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1036172005504	S17 interaction site [polypeptide binding]; other site
1036172005505	S8 interaction site; other site
1036172005506	16S rRNA interaction site [nucleotide binding]; other site
1036172005507	streptomycin interaction site [chemical binding]; other site
1036172005508	23S rRNA interaction site [nucleotide binding]; other site
1036172005509	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1036172005510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036172005511	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036172005512	MFS transport protein AraJ; Provisional; Region: PRK10091
1036172005513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172005514	putative substrate translocation pore; other site
1036172005515	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
1036172005516	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172005517	N-terminal plug; other site
1036172005518	ligand-binding site [chemical binding]; other site
1036172005519	NMT1/THI5 like; Region: NMT1; pfam09084
1036172005520	Protein of unknown function (DUF3834); Region: DUF3834; pfam12916
1036172005521	NnrS protein; Region: NnrS; pfam05940
1036172005522	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036172005523	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172005524	Walker A/P-loop; other site
1036172005525	ATP binding site [chemical binding]; other site
1036172005526	Q-loop/lid; other site
1036172005527	ABC transporter signature motif; other site
1036172005528	Walker B; other site
1036172005529	D-loop; other site
1036172005530	H-loop/switch region; other site
1036172005531	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036172005532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036172005533	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1036172005534	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1036172005535	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1036172005536	glutamine binding [chemical binding]; other site
1036172005537	catalytic triad [active]
1036172005538	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1036172005539	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036172005540	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1036172005541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172005542	dimer interface [polypeptide binding]; other site
1036172005543	conserved gate region; other site
1036172005544	putative PBP binding loops; other site
1036172005545	ABC-ATPase subunit interface; other site
1036172005546	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1036172005547	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1036172005548	Walker A/P-loop; other site
1036172005549	ATP binding site [chemical binding]; other site
1036172005550	Q-loop/lid; other site
1036172005551	ABC transporter signature motif; other site
1036172005552	Walker B; other site
1036172005553	D-loop; other site
1036172005554	H-loop/switch region; other site
1036172005555	TOBE domain; Region: TOBE_2; pfam08402
1036172005556	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172005557	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172005558	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172005559	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172005560	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172005561	N-terminal plug; other site
1036172005562	ligand-binding site [chemical binding]; other site
1036172005563	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1036172005564	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1036172005565	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1036172005566	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1036172005567	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036172005568	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036172005569	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873
1036172005570	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873
1036172005571	metal binding site [ion binding]; metal-binding site
1036172005572	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1036172005573	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1036172005574	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1036172005575	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1036172005576	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1036172005577	RNA binding site [nucleotide binding]; other site
1036172005578	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1036172005579	homotrimer interaction site [polypeptide binding]; other site
1036172005580	putative active site [active]
1036172005581	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036172005582	nudix motif; other site
1036172005583	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172005584	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172005585	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036172005586	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1036172005587	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172005588	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172005589	homodimer interface [polypeptide binding]; other site
1036172005590	catalytic residue [active]
1036172005591	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036172005592	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036172005593	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1036172005594	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1036172005595	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1036172005596	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1036172005597	THF binding site; other site
1036172005598	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1036172005599	substrate binding site [chemical binding]; other site
1036172005600	THF binding site; other site
1036172005601	zinc-binding site [ion binding]; other site
1036172005602	threonine dehydratase; Provisional; Region: PRK08526
1036172005603	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1036172005604	tetramer interface [polypeptide binding]; other site
1036172005605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172005606	catalytic residue [active]
1036172005607	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1036172005608	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1036172005609	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1036172005610	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1036172005611	thiamine phosphate binding site [chemical binding]; other site
1036172005612	active site
1036172005613	pyrophosphate binding site [ion binding]; other site
1036172005614	Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538
1036172005615	Dihydroneopterin aldolase; Region: FolB; pfam02152
1036172005616	active site
1036172005617	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1036172005618	quinolinate synthetase; Provisional; Region: PRK09375
1036172005619	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848
1036172005620	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1036172005621	dimerization interface [polypeptide binding]; other site
1036172005622	active site
1036172005623	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1036172005624	DHH family; Region: DHH; pfam01368
1036172005625	DHHA1 domain; Region: DHHA1; pfam02272
1036172005626	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036172005627	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036172005628	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1036172005629	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1036172005630	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1036172005631	homoserine kinase; Provisional; Region: PRK01212
1036172005632	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1036172005633	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
1036172005634	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1036172005635	translation initiation factor IF-2; Region: IF-2; TIGR00487
1036172005636	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1036172005637	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1036172005638	G1 box; other site
1036172005639	putative GEF interaction site [polypeptide binding]; other site
1036172005640	GTP/Mg2+ binding site [chemical binding]; other site
1036172005641	Switch I region; other site
1036172005642	G2 box; other site
1036172005643	G3 box; other site
1036172005644	Switch II region; other site
1036172005645	G4 box; other site
1036172005646	G5 box; other site
1036172005647	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1036172005648	Translation-initiation factor 2; Region: IF-2; pfam11987
1036172005649	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1036172005650	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1036172005651	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1036172005652	Sm and related proteins; Region: Sm_like; cl00259
1036172005653	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1036172005654	putative oligomer interface [polypeptide binding]; other site
1036172005655	putative RNA binding site [nucleotide binding]; other site
1036172005656	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1036172005657	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1036172005658	catalytic motif [active]
1036172005659	Zn binding site [ion binding]; other site
1036172005660	RibD C-terminal domain; Region: RibD_C; cl17279
1036172005661	elongation factor P; Validated; Region: PRK00529
1036172005662	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1036172005663	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1036172005664	RNA binding site [nucleotide binding]; other site
1036172005665	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1036172005666	RNA binding site [nucleotide binding]; other site
1036172005667	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1036172005668	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1036172005669	ligand binding site [chemical binding]; other site
1036172005670	NAD binding site [chemical binding]; other site
1036172005671	dimerization interface [polypeptide binding]; other site
1036172005672	catalytic site [active]
1036172005673	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1036172005674	putative L-serine binding site [chemical binding]; other site
1036172005675	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1036172005676	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1036172005677	RNA binding site [nucleotide binding]; other site
1036172005678	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1036172005679	RNA binding site [nucleotide binding]; other site
1036172005680	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036172005681	RNA binding site [nucleotide binding]; other site
1036172005682	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036172005683	RNA binding site [nucleotide binding]; other site
1036172005684	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036172005685	RNA binding site [nucleotide binding]; other site
1036172005686	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1036172005687	RNA binding site [nucleotide binding]; other site
1036172005688	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1036172005689	LytB protein; Region: LYTB; pfam02401
1036172005690	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1036172005691	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1036172005692	hinge; other site
1036172005693	active site
1036172005694	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1036172005695	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1036172005696	putative tRNA-binding site [nucleotide binding]; other site
1036172005697	tRNA synthetase B5 domain; Region: B5; smart00874
1036172005698	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1036172005699	dimer interface [polypeptide binding]; other site
1036172005700	motif 1; other site
1036172005701	motif 3; other site
1036172005702	motif 2; other site
1036172005703	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1036172005704	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1036172005705	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1036172005706	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1036172005707	dimer interface [polypeptide binding]; other site
1036172005708	motif 1; other site
1036172005709	active site
1036172005710	motif 2; other site
1036172005711	motif 3; other site
1036172005712	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1036172005713	nucleotide binding site/active site [active]
1036172005714	HIT family signature motif; other site
1036172005715	catalytic residue [active]
1036172005716	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1036172005717	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439
1036172005718	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1036172005719	dimer interface [polypeptide binding]; other site
1036172005720	active site
1036172005721	acyl carrier protein; Provisional; Region: acpP; PRK00982
1036172005722	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036172005723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036172005724	NAD(P) binding site [chemical binding]; other site
1036172005725	active site
1036172005726	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1036172005727	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1036172005728	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1036172005729	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1036172005730	Ligand Binding Site [chemical binding]; other site
1036172005731	RNA methyltransferase, RsmE family; Region: TIGR00046
1036172005732	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1036172005733	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
1036172005734	Cytochrome c; Region: Cytochrom_C; pfam00034
1036172005735	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1036172005736	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1036172005737	intrachain domain interface; other site
1036172005738	interchain domain interface [polypeptide binding]; other site
1036172005739	heme bH binding site [chemical binding]; other site
1036172005740	Qi binding site; other site
1036172005741	heme bL binding site [chemical binding]; other site
1036172005742	Qo binding site; other site
1036172005743	interchain domain interface [polypeptide binding]; other site
1036172005744	intrachain domain interface; other site
1036172005745	Qi binding site; other site
1036172005746	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1036172005747	Qo binding site; other site
1036172005748	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1036172005749	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1036172005750	iron-sulfur cluster [ion binding]; other site
1036172005751	[2Fe-2S] cluster binding site [ion binding]; other site
1036172005752	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1036172005753	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1036172005754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172005755	catalytic residue [active]
1036172005756	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1036172005757	feedback inhibition sensing region; other site
1036172005758	homohexameric interface [polypeptide binding]; other site
1036172005759	nucleotide binding site [chemical binding]; other site
1036172005760	N-acetyl-L-glutamate binding site [chemical binding]; other site
1036172005761	putative recombination protein RecB; Provisional; Region: PRK13909
1036172005762	Part of AAA domain; Region: AAA_19; pfam13245
1036172005763	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1036172005764	Cytochrome c; Region: Cytochrom_C; cl11414
1036172005765	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1036172005766	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1036172005767	RF-1 domain; Region: RF-1; pfam00472
1036172005768	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172005769	MULE transposase domain; Region: MULE; pfam10551
1036172005770	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
1036172005771	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1036172005772	FixH; Region: FixH; pfam05751
1036172005773	Family of unknown function (DUF4006); Region: DUF4006; pfam13179
1036172005774	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1036172005775	Cytochrome c; Region: Cytochrom_C; pfam00034
1036172005776	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1036172005777	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
1036172005778	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1036172005779	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
1036172005780	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
1036172005781	Low-spin heme binding site [chemical binding]; other site
1036172005782	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1036172005783	D-pathway; other site
1036172005784	Putative water exit pathway; other site
1036172005785	Binuclear center (active site) [active]
1036172005786	K-pathway; other site
1036172005787	Putative proton exit pathway; other site
1036172005788	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1036172005789	SmpB-tmRNA interface; other site
1036172005790	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
1036172005791	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1036172005792	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099
1036172005793	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1036172005794	active site
1036172005795	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1036172005796	Part of AAA domain; Region: AAA_19; pfam13245
1036172005797	Family description; Region: UvrD_C_2; pfam13538
1036172005798	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036172005799	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036172005800	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1036172005801	dimerization interface [polypeptide binding]; other site
1036172005802	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1036172005803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172005804	amidophosphoribosyltransferase; Provisional; Region: PRK08525
1036172005805	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1036172005806	active site
1036172005807	tetramer interface [polypeptide binding]; other site
1036172005808	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172005809	active site
1036172005810	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1036172005811	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1036172005812	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1036172005813	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1036172005814	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036172005815	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036172005816	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036172005817	catalytic residues [active]
1036172005818	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1036172005819	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1036172005820	motif 1; other site
1036172005821	active site
1036172005822	motif 2; other site
1036172005823	motif 3; other site
1036172005824	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1036172005825	DHHA1 domain; Region: DHHA1; pfam02272
1036172005826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
1036172005827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172005828	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172005829	putative substrate translocation pore; other site
1036172005830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172005831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036172005832	dimer interface [polypeptide binding]; other site
1036172005833	phosphorylation site [posttranslational modification]
1036172005834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172005835	ATP binding site [chemical binding]; other site
1036172005836	Mg2+ binding site [ion binding]; other site
1036172005837	G-X-G motif; other site
1036172005838	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172005839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172005840	active site
1036172005841	phosphorylation site [posttranslational modification]
1036172005842	intermolecular recognition site; other site
1036172005843	dimerization interface [polypeptide binding]; other site
1036172005844	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172005845	DNA binding site [nucleotide binding]
1036172005846	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1036172005847	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036172005848	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036172005849	protein binding site [polypeptide binding]; other site
1036172005850	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036172005851	protein binding site [polypeptide binding]; other site
1036172005852	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1036172005853	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036172005854	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036172005855	Walker A/P-loop; other site
1036172005856	ATP binding site [chemical binding]; other site
1036172005857	Q-loop/lid; other site
1036172005858	ABC transporter signature motif; other site
1036172005859	Walker B; other site
1036172005860	D-loop; other site
1036172005861	H-loop/switch region; other site
1036172005862	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1036172005863	FtsX-like permease family; Region: FtsX; pfam02687
1036172005864	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1036172005865	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
1036172005866	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1036172005867	active site
1036172005868	PQQ-like domain; Region: PQQ_2; pfam13360
1036172005869	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1036172005870	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1036172005871	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1036172005872	protein binding site [polypeptide binding]; other site
1036172005873	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1036172005874	Catalytic dyad [active]
1036172005875	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1036172005876	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
1036172005877	ATP binding site [chemical binding]; other site
1036172005878	active site
1036172005879	substrate binding site [chemical binding]; other site
1036172005880	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1036172005881	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1036172005882	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1036172005883	putative active site [active]
1036172005884	catalytic triad [active]
1036172005885	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1036172005886	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1036172005887	putative acyl-acceptor binding pocket; other site
1036172005888	CrcB-like protein; Region: CRCB; cl09114
1036172005889	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1036172005890	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
1036172005891	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1036172005892	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1036172005893	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1036172005894	active site
1036172005895	HIGH motif; other site
1036172005896	KMSK motif region; other site
1036172005897	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1036172005898	tRNA binding surface [nucleotide binding]; other site
1036172005899	anticodon binding site; other site
1036172005900	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1036172005901	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1036172005902	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1036172005903	active site
1036172005904	(T/H)XGH motif; other site
1036172005905	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1036172005906	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1036172005907	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1036172005908	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1036172005909	Phosphoglycerate kinase; Region: PGK; pfam00162
1036172005910	substrate binding site [chemical binding]; other site
1036172005911	hinge regions; other site
1036172005912	ADP binding site [chemical binding]; other site
1036172005913	catalytic site [active]
1036172005914	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1036172005915	triosephosphate isomerase; Provisional; Region: PRK14565
1036172005916	substrate binding site [chemical binding]; other site
1036172005917	dimer interface [polypeptide binding]; other site
1036172005918	catalytic triad [active]
1036172005919	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415
1036172005920	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1036172005921	NAD binding site [chemical binding]; other site
1036172005922	homotetramer interface [polypeptide binding]; other site
1036172005923	homodimer interface [polypeptide binding]; other site
1036172005924	substrate binding site [chemical binding]; other site
1036172005925	active site
1036172005926	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1036172005927	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1036172005928	active site
1036172005929	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036172005930	substrate binding site [chemical binding]; other site
1036172005931	catalytic residues [active]
1036172005932	dimer interface [polypeptide binding]; other site
1036172005933	Chorismate mutase type II; Region: CM_2; cl00693
1036172005934	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1036172005935	Prephenate dehydratase; Region: PDT; pfam00800
1036172005936	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1036172005937	putative L-Phe binding site [chemical binding]; other site
1036172005938	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1036172005939	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036172005940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172005941	homodimer interface [polypeptide binding]; other site
1036172005942	catalytic residue [active]
1036172005943	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1036172005944	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1036172005945	TPP-binding site; other site
1036172005946	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036172005947	PYR/PP interface [polypeptide binding]; other site
1036172005948	dimer interface [polypeptide binding]; other site
1036172005949	TPP binding site [chemical binding]; other site
1036172005950	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036172005951	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1036172005952	Maf-like protein; Reviewed; Region: PRK04056
1036172005953	Maf-like protein; Region: Maf; pfam02545
1036172005954	putative active site [active]
1036172005955	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1036172005956	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1036172005957	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1036172005958	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036172005959	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036172005960	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036172005961	ligand binding site [chemical binding]; other site
1036172005962	flexible hinge region; other site
1036172005963	putative switch regulator; other site
1036172005964	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1036172005965	non-specific DNA interactions [nucleotide binding]; other site
1036172005966	DNA binding site [nucleotide binding]
1036172005967	sequence specific DNA binding site [nucleotide binding]; other site
1036172005968	putative cAMP binding site [chemical binding]; other site
1036172005969	hypothetical protein; Provisional; Region: PRK10410
1036172005970	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1036172005971	ligand binding site [chemical binding]; other site
1036172005972	active site
1036172005973	UGI interface [polypeptide binding]; other site
1036172005974	catalytic site [active]
1036172005975	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036172005976	Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148
1036172005977	NAD(P) binding site [chemical binding]; other site
1036172005978	catalytic residues [active]
1036172005979	acetolactate synthase; Reviewed; Region: PRK08322
1036172005980	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036172005981	PYR/PP interface [polypeptide binding]; other site
1036172005982	dimer interface [polypeptide binding]; other site
1036172005983	TPP binding site [chemical binding]; other site
1036172005984	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036172005985	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1036172005986	TPP-binding site [chemical binding]; other site
1036172005987	dimer interface [polypeptide binding]; other site
1036172005988	LemA family; Region: LemA; pfam04011
1036172005989	Repair protein; Region: Repair_PSII; cl01535
1036172005990	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1036172005991	Repair protein; Region: Repair_PSII; pfam04536
1036172005992	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036172005993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036172005994	motif II; other site
1036172005995	Ferritin-like domain; Region: Ferritin; pfam00210
1036172005996	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1036172005997	dimerization interface [polypeptide binding]; other site
1036172005998	DPS ferroxidase diiron center [ion binding]; other site
1036172005999	ion pore; other site
1036172006000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172006001	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172006002	putative substrate translocation pore; other site
1036172006003	HAMP domain; Region: HAMP; pfam00672
1036172006004	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172006005	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172006006	metal binding site [ion binding]; metal-binding site
1036172006007	active site
1036172006008	I-site; other site
1036172006009	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036172006010	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036172006011	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172006012	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1036172006013	Protein export membrane protein; Region: SecD_SecF; cl14618
1036172006014	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1036172006015	AAA domain; Region: AAA_14; pfam13173
1036172006016	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
1036172006017	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172006018	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172006019	N-terminal plug; other site
1036172006020	ligand-binding site [chemical binding]; other site
1036172006021	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1036172006022	FecR protein; Region: FecR; pfam04773
1036172006023	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1036172006024	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036172006025	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036172006026	DNA binding residues [nucleotide binding]
1036172006027	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
1036172006028	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1036172006029	flavoprotein, HI0933 family; Region: TIGR00275
1036172006030	Cupin domain; Region: Cupin_2; pfam07883
1036172006031	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1036172006032	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1036172006033	homodimer interface [polypeptide binding]; other site
1036172006034	substrate-cofactor binding pocket; other site
1036172006035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006036	catalytic residue [active]
1036172006037	Transcriptional regulator; Region: Rrf2; pfam02082
1036172006038	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1036172006039	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036172006040	dimer interface [polypeptide binding]; other site
1036172006041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006042	catalytic residue [active]
1036172006043	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
1036172006044	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1036172006045	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1036172006046	Active Sites [active]
1036172006047	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1036172006048	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1036172006049	Active Sites [active]
1036172006050	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1036172006051	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1036172006052	CysD dimerization site [polypeptide binding]; other site
1036172006053	G1 box; other site
1036172006054	putative GEF interaction site [polypeptide binding]; other site
1036172006055	GTP/Mg2+ binding site [chemical binding]; other site
1036172006056	Switch I region; other site
1036172006057	G2 box; other site
1036172006058	G3 box; other site
1036172006059	Switch II region; other site
1036172006060	G4 box; other site
1036172006061	G5 box; other site
1036172006062	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1036172006063	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1036172006064	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036172006065	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1036172006066	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036172006067	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1036172006068	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1036172006069	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036172006070	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036172006071	catalytic residue [active]
1036172006072	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1036172006073	metal ion-dependent adhesion site (MIDAS); other site
1036172006074	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036172006075	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1036172006076	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
1036172006077	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036172006078	active site
1036172006079	catalytic triad [active]
1036172006080	oxyanion hole [active]
1036172006081	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1036172006082	putative dimer interface [polypeptide binding]; other site
1036172006083	active site pocket [active]
1036172006084	putative cataytic base [active]
1036172006085	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1036172006086	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
1036172006087	transmembrane helices; other site
1036172006088	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036172006089	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1036172006090	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1036172006091	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1036172006092	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1036172006093	DsbD alpha interface [polypeptide binding]; other site
1036172006094	catalytic residues [active]
1036172006095	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1036172006096	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036172006097	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
1036172006098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172006099	metal binding site [ion binding]; metal-binding site
1036172006100	active site
1036172006101	I-site; other site
1036172006102	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172006103	phosphatidylserine decarboxylase; Provisional; Region: PRK03934
1036172006104	MltA specific insert domain; Region: MltA; smart00925
1036172006105	3D domain; Region: 3D; pfam06725
1036172006106	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1036172006107	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1036172006108	nucleotide binding site [chemical binding]; other site
1036172006109	NEF interaction site [polypeptide binding]; other site
1036172006110	SBD interface [polypeptide binding]; other site
1036172006111	GrpE; Region: GrpE; pfam01025
1036172006112	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1036172006113	dimer interface [polypeptide binding]; other site
1036172006114	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1036172006115	heat-inducible transcription repressor; Provisional; Region: PRK03911
1036172006116	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
1036172006117	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1036172006118	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1036172006119	dimerization interface 3.5A [polypeptide binding]; other site
1036172006120	active site
1036172006121	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1036172006122	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1036172006123	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14833
1036172006124	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1036172006125	catalytic residue [active]
1036172006126	putative FPP diphosphate  binding site; other site
1036172006127	putative FPP binding hydrophobic cleft; other site
1036172006128	dimer interface [polypeptide binding]; other site
1036172006129	putative IPP diphosphate binding site; other site
1036172006130	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1036172006131	Flavoprotein; Region: Flavoprotein; pfam02441
1036172006132	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1036172006133	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359
1036172006134	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1036172006135	Substrate binding site; other site
1036172006136	Mg++ binding site; other site
1036172006137	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1036172006138	active site
1036172006139	substrate binding site [chemical binding]; other site
1036172006140	CoA binding site [chemical binding]; other site
1036172006141	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006142	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172006143	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006144	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172006145	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006146	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006147	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172006148	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006149	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172006150	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036172006151	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036172006152	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1036172006153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036172006154	nucleotide binding region [chemical binding]; other site
1036172006155	ATP-binding site [chemical binding]; other site
1036172006156	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
1036172006157	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1036172006158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172006159	S-adenosylmethionine binding site [chemical binding]; other site
1036172006160	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036172006161	nudix motif; other site
1036172006162	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
1036172006163	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
1036172006164	Helix-turn-helix domain; Region: HTH_28; pfam13518
1036172006165	Integrase core domain; Region: rve; pfam00665
1036172006166	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1036172006167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172006168	AAA domain; Region: AAA_22; pfam13401
1036172006169	Walker A motif; other site
1036172006170	ATP binding site [chemical binding]; other site
1036172006171	Walker B motif; other site
1036172006172	TniQ; Region: TniQ; pfam06527
1036172006173	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1036172006174	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1036172006175	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1036172006176	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1036172006177	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1036172006178	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1036172006179	Lumazine binding domain; Region: Lum_binding; pfam00677
1036172006180	Lumazine binding domain; Region: Lum_binding; pfam00677
1036172006181	rod shape-determining protein MreC; Provisional; Region: PRK13922
1036172006182	rod shape-determining protein MreC; Region: MreC; pfam04085
1036172006183	rod shape-determining protein MreB; Provisional; Region: PRK13927
1036172006184	MreB and similar proteins; Region: MreB_like; cd10225
1036172006185	nucleotide binding site [chemical binding]; other site
1036172006186	Mg binding site [ion binding]; other site
1036172006187	putative protofilament interaction site [polypeptide binding]; other site
1036172006188	RodZ interaction site [polypeptide binding]; other site
1036172006189	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1036172006190	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
1036172006191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036172006192	Walker A motif; other site
1036172006193	ATP binding site [chemical binding]; other site
1036172006194	Walker B motif; other site
1036172006195	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1036172006196	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1036172006197	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1036172006198	active site
1036172006199	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1036172006200	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1036172006201	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
1036172006202	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
1036172006203	Ligand Binding Site [chemical binding]; other site
1036172006204	Double zinc ribbon; Region: DZR; pfam12773
1036172006205	Double zinc ribbon; Region: DZR; pfam12773
1036172006206	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1036172006207	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1036172006208	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036172006209	ligand binding site [chemical binding]; other site
1036172006210	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1036172006211	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036172006212	endonuclease IV; Provisional; Region: PRK01060
1036172006213	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1036172006214	AP (apurinic/apyrimidinic) site pocket; other site
1036172006215	DNA interaction; other site
1036172006216	Metal-binding active site; metal-binding site
1036172006217	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1036172006218	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1036172006219	Protein export membrane protein; Region: SecD_SecF; cl14618
1036172006220	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036172006221	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036172006222	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036172006223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036172006224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036172006225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036172006226	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036172006227	putative substrate translocation pore; other site
1036172006228	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1036172006229	putative transporter; Provisional; Region: PRK11660
1036172006230	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1036172006231	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1036172006232	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172006233	Sel1 repeat; Region: Sel1; cl02723
1036172006234	Sel1-like repeats; Region: SEL1; smart00671
1036172006235	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1036172006236	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1036172006237	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
1036172006238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036172006239	active site
1036172006240	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
1036172006241	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904
1036172006242	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1036172006243	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1036172006244	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1036172006245	active site
1036172006246	interdomain interaction site; other site
1036172006247	putative metal-binding site [ion binding]; other site
1036172006248	nucleotide binding site [chemical binding]; other site
1036172006249	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1036172006250	domain I; other site
1036172006251	DNA binding groove [nucleotide binding]
1036172006252	phosphate binding site [ion binding]; other site
1036172006253	domain II; other site
1036172006254	domain III; other site
1036172006255	nucleotide binding site [chemical binding]; other site
1036172006256	catalytic site [active]
1036172006257	domain IV; other site
1036172006258	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1036172006259	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1036172006260	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1036172006261	active site
1036172006262	metal binding site [ion binding]; metal-binding site
1036172006263	homotetramer interface [polypeptide binding]; other site
1036172006264	biotin synthase; Provisional; Region: PRK08508
1036172006265	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036172006266	FeS/SAM binding site; other site
1036172006267	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1036172006268	AMIN domain; Region: AMIN; pfam11741
1036172006269	enolase; Provisional; Region: eno; PRK00077
1036172006270	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1036172006271	dimer interface [polypeptide binding]; other site
1036172006272	metal binding site [ion binding]; metal-binding site
1036172006273	substrate binding pocket [chemical binding]; other site
1036172006274	recombinase A; Provisional; Region: recA; PRK09354
1036172006275	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1036172006276	hexamer interface [polypeptide binding]; other site
1036172006277	Walker A motif; other site
1036172006278	ATP binding site [chemical binding]; other site
1036172006279	Walker B motif; other site
1036172006280	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
1036172006281	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1036172006282	NAD(P) binding site [chemical binding]; other site
1036172006283	homodimer interface [polypeptide binding]; other site
1036172006284	substrate binding site [chemical binding]; other site
1036172006285	active site
1036172006286	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1036172006287	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1036172006288	inhibitor-cofactor binding pocket; inhibition site
1036172006289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006290	catalytic residue [active]
1036172006291	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1036172006292	ligand binding site; other site
1036172006293	tetramer interface; other site
1036172006294	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
1036172006295	pseudaminic acid synthase; Region: PseI; TIGR03586
1036172006296	NeuB family; Region: NeuB; pfam03102
1036172006297	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1036172006298	NeuB binding interface [polypeptide binding]; other site
1036172006299	putative substrate binding site [chemical binding]; other site
1036172006300	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
1036172006301	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1036172006302	classical (c) SDRs; Region: SDR_c; cd05233
1036172006303	NAD(P) binding site [chemical binding]; other site
1036172006304	active site
1036172006305	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1036172006306	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1036172006307	acyl-activating enzyme (AAE) consensus motif; other site
1036172006308	active site
1036172006309	AMP binding site [chemical binding]; other site
1036172006310	CoA binding site [chemical binding]; other site
1036172006311	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1036172006312	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1036172006313	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1036172006314	substrate binding site; other site
1036172006315	dimer interface; other site
1036172006316	classical (c) SDRs; Region: SDR_c; cd05233
1036172006317	NAD(P) binding site [chemical binding]; other site
1036172006318	active site
1036172006319	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036172006320	active site
1036172006321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036172006322	active site
1036172006323	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036172006324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172006325	S-adenosylmethionine binding site [chemical binding]; other site
1036172006326	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1036172006327	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1036172006328	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036172006329	active site
1036172006330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172006331	S-adenosylmethionine binding site [chemical binding]; other site
1036172006332	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1036172006333	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1036172006334	putative trimer interface [polypeptide binding]; other site
1036172006335	putative CoA binding site [chemical binding]; other site
1036172006336	WbqC-like protein family; Region: WbqC; pfam08889
1036172006337	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1036172006338	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1036172006339	inhibitor-cofactor binding pocket; inhibition site
1036172006340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006341	catalytic residue [active]
1036172006342	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
1036172006343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
1036172006344	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
1036172006345	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
1036172006346	flagellin; Provisional; Region: PRK12804
1036172006347	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036172006348	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036172006349	flagellin; Provisional; Region: PRK12804
1036172006350	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036172006351	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036172006352	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1036172006353	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1036172006354	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1036172006355	CTP synthetase; Validated; Region: pyrG; PRK05380
1036172006356	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1036172006357	Catalytic site [active]
1036172006358	active site
1036172006359	UTP binding site [chemical binding]; other site
1036172006360	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1036172006361	active site
1036172006362	putative oxyanion hole; other site
1036172006363	catalytic triad [active]
1036172006364	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1036172006365	DHH family; Region: DHH; pfam01368
1036172006366	DHHA1 domain; Region: DHHA1; pfam02272
1036172006367	Predicted integral membrane protein [Function unknown]; Region: COG5616
1036172006368	DJ-1 family protein; Region: not_thiJ; TIGR01383
1036172006369	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1036172006370	conserved cys residue [active]
1036172006371	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1036172006372	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1036172006373	active site
1036172006374	PHP Thumb interface [polypeptide binding]; other site
1036172006375	metal binding site [ion binding]; metal-binding site
1036172006376	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1036172006377	generic binding surface II; other site
1036172006378	generic binding surface I; other site
1036172006379	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1036172006380	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036172006381	MULE transposase domain; Region: MULE; pfam10551
1036172006382	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1036172006383	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1036172006384	trimer interface [polypeptide binding]; other site
1036172006385	dimer interface [polypeptide binding]; other site
1036172006386	putative active site [active]
1036172006387	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1036172006388	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1036172006389	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1036172006390	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1036172006391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172006392	S-adenosylmethionine binding site [chemical binding]; other site
1036172006393	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1036172006394	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1036172006395	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1036172006396	hinge region; other site
1036172006397	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036172006398	active site
1036172006399	RDD family; Region: RDD; pfam06271
1036172006400	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1036172006401	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1036172006402	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1036172006403	Cl binding site [ion binding]; other site
1036172006404	oligomer interface [polypeptide binding]; other site
1036172006405	Protein of unknown function (DUF328); Region: DUF328; pfam03883
1036172006406	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1036172006407	Helix-hairpin-helix motif; Region: HHH; pfam00633
1036172006408	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1036172006409	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036172006410	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036172006411	putative active site [active]
1036172006412	putative metal binding site [ion binding]; other site
1036172006413	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1036172006414	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1036172006415	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1036172006416	N-terminal plug; other site
1036172006417	ligand-binding site [chemical binding]; other site
1036172006418	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036172006419	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1036172006420	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1036172006421	putative dimer interface [polypeptide binding]; other site
1036172006422	Hemerythrin; Region: Hemerythrin; cd12107
1036172006423	Fe binding site [ion binding]; other site
1036172006424	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1036172006425	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036172006426	dimer interface [polypeptide binding]; other site
1036172006427	putative CheW interface [polypeptide binding]; other site
1036172006428	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1036172006429	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1036172006430	ATP binding site [chemical binding]; other site
1036172006431	substrate interface [chemical binding]; other site
1036172006432	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036172006433	active site residue [active]
1036172006434	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036172006435	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1036172006436	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036172006437	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1036172006438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1036172006439	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1036172006440	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1036172006441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1036172006442	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036172006443	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1036172006444	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036172006445	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1036172006446	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1036172006447	Walker A/P-loop; other site
1036172006448	ATP binding site [chemical binding]; other site
1036172006449	Q-loop/lid; other site
1036172006450	ABC transporter signature motif; other site
1036172006451	Walker B; other site
1036172006452	D-loop; other site
1036172006453	H-loop/switch region; other site
1036172006454	TOBE-like domain; Region: TOBE_3; pfam12857
1036172006455	sulfate transport protein; Provisional; Region: cysT; CHL00187
1036172006456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172006457	dimer interface [polypeptide binding]; other site
1036172006458	conserved gate region; other site
1036172006459	putative PBP binding loops; other site
1036172006460	ABC-ATPase subunit interface; other site
1036172006461	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1036172006462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172006463	dimer interface [polypeptide binding]; other site
1036172006464	conserved gate region; other site
1036172006465	putative PBP binding loops; other site
1036172006466	ABC-ATPase subunit interface; other site
1036172006467	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1036172006468	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036172006469	dimer interface [polypeptide binding]; other site
1036172006470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006471	catalytic residue [active]
1036172006472	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172006473	metal binding site [ion binding]; metal-binding site
1036172006474	active site
1036172006475	I-site; other site
1036172006476	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036172006477	Ubiquitin-like proteins; Region: UBQ; cl00155
1036172006478	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1036172006479	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1036172006480	threonine synthase; Validated; Region: PRK08197
1036172006481	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1036172006482	homodimer interface [polypeptide binding]; other site
1036172006483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036172006484	catalytic residue [active]
1036172006485	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036172006486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172006487	dimer interface [polypeptide binding]; other site
1036172006488	conserved gate region; other site
1036172006489	putative PBP binding loops; other site
1036172006490	ABC-ATPase subunit interface; other site
1036172006491	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036172006492	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036172006493	Walker A/P-loop; other site
1036172006494	ATP binding site [chemical binding]; other site
1036172006495	Q-loop/lid; other site
1036172006496	ABC transporter signature motif; other site
1036172006497	Walker B; other site
1036172006498	D-loop; other site
1036172006499	H-loop/switch region; other site
1036172006500	NMT1-like family; Region: NMT1_2; pfam13379
1036172006501	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036172006502	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036172006503	Amidohydrolase; Region: Amidohydro_2; pfam04909
1036172006504	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1036172006505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036172006506	Walker A/P-loop; other site
1036172006507	ATP binding site [chemical binding]; other site
1036172006508	Q-loop/lid; other site
1036172006509	ABC transporter signature motif; other site
1036172006510	Walker B; other site
1036172006511	D-loop; other site
1036172006512	H-loop/switch region; other site
1036172006513	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036172006514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036172006515	putative PBP binding loops; other site
1036172006516	dimer interface [polypeptide binding]; other site
1036172006517	ABC-ATPase subunit interface; other site
1036172006518	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1036172006519	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1036172006520	active site
1036172006521	dimer interface [polypeptide binding]; other site
1036172006522	non-prolyl cis peptide bond; other site
1036172006523	insertion regions; other site
1036172006524	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036172006525	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036172006526	substrate binding pocket [chemical binding]; other site
1036172006527	membrane-bound complex binding site; other site
1036172006528	hinge residues; other site
1036172006529	Rrf2 family protein; Region: rrf2_super; TIGR00738
1036172006530	Transcriptional regulator; Region: Rrf2; pfam02082
1036172006531	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1036172006532	active site
1036172006533	Zn binding site [ion binding]; other site
1036172006534	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253
1036172006535	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1036172006536	putative active site [active]
1036172006537	Zn binding site [ion binding]; other site
1036172006538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1036172006539	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1036172006540	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1036172006541	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1036172006542	G1 box; other site
1036172006543	putative GEF interaction site [polypeptide binding]; other site
1036172006544	GTP/Mg2+ binding site [chemical binding]; other site
1036172006545	Switch I region; other site
1036172006546	G2 box; other site
1036172006547	G3 box; other site
1036172006548	Switch II region; other site
1036172006549	G4 box; other site
1036172006550	G5 box; other site
1036172006551	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1036172006552	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1036172006553	putative inner membrane protein; Provisional; Region: PRK11099
1036172006554	hypothetical protein; Provisional; Region: PRK11018
1036172006555	CPxP  motif; other site
1036172006556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172006557	PAS fold; Region: PAS_3; pfam08447
1036172006558	putative active site [active]
1036172006559	heme pocket [chemical binding]; other site
1036172006560	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172006561	putative active site [active]
1036172006562	PAS fold; Region: PAS_3; pfam08447
1036172006563	heme pocket [chemical binding]; other site
1036172006564	PAS domain S-box; Region: sensory_box; TIGR00229
1036172006565	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036172006566	putative active site [active]
1036172006567	heme pocket [chemical binding]; other site
1036172006568	PAS domain S-box; Region: sensory_box; TIGR00229
1036172006569	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036172006570	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036172006571	metal binding site [ion binding]; metal-binding site
1036172006572	active site
1036172006573	I-site; other site
1036172006574	putative metal dependent hydrolase; Provisional; Region: PRK11598
1036172006575	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1036172006576	Sulfatase; Region: Sulfatase; pfam00884
1036172006577	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
1036172006578	active site
1036172006579	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
1036172006580	Dihaem cytochrome c; Region: DHC; pfam09626
1036172006581	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1036172006582	Dihaem cytochrome c; Region: DHC; pfam09626
1036172006583	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036172006584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036172006585	active site
1036172006586	phosphorylation site [posttranslational modification]
1036172006587	intermolecular recognition site; other site
1036172006588	dimerization interface [polypeptide binding]; other site
1036172006589	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036172006590	DNA binding site [nucleotide binding]
1036172006591	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036172006592	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036172006593	dimerization interface [polypeptide binding]; other site
1036172006594	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1036172006595	dimer interface [polypeptide binding]; other site
1036172006596	phosphorylation site [posttranslational modification]
1036172006597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036172006598	ATP binding site [chemical binding]; other site
1036172006599	Mg2+ binding site [ion binding]; other site
1036172006600	G-X-G motif; other site
1036172006601	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1036172006602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036172006603	S-adenosylmethionine binding site [chemical binding]; other site
1036172006604	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1036172006605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036172006606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036172006607	Zn2+ binding site [ion binding]; other site
1036172006608	Mg2+ binding site [ion binding]; other site
1036172006609	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
1036172006610	Predicted membrane protein [Function unknown]; Region: COG2860
1036172006611	UPF0126 domain; Region: UPF0126; pfam03458
1036172006612	UPF0126 domain; Region: UPF0126; pfam03458
1036172006613	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
1036172006614	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1036172006615	active site
1036172006616	substrate binding site [chemical binding]; other site
1036172006617	cosubstrate binding site; other site
1036172006618	catalytic site [active]
1036172006619	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1036172006620	active site
1036172006621	putative DNA-binding cleft [nucleotide binding]; other site
1036172006622	dimer interface [polypeptide binding]; other site