-- dump date 20140618_204840 -- class Genbank::misc_feature -- table misc_feature_note -- id note 944546000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 944546000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546000003 Walker A motif; other site 944546000004 ATP binding site [chemical binding]; other site 944546000005 Walker B motif; other site 944546000006 arginine finger; other site 944546000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 944546000008 DnaA box-binding interface [nucleotide binding]; other site 944546000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 944546000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 944546000011 putative DNA binding surface [nucleotide binding]; other site 944546000012 dimer interface [polypeptide binding]; other site 944546000013 beta-clamp/clamp loader binding surface; other site 944546000014 beta-clamp/translesion DNA polymerase binding surface; other site 944546000015 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 944546000016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546000017 Mg2+ binding site [ion binding]; other site 944546000018 G-X-G motif; other site 944546000019 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 944546000020 anchoring element; other site 944546000021 dimer interface [polypeptide binding]; other site 944546000022 ATP binding site [chemical binding]; other site 944546000023 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 944546000024 active site 944546000025 putative metal-binding site [ion binding]; other site 944546000026 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 944546000027 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 944546000028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944546000029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944546000030 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 944546000031 Predicted membrane protein [Function unknown]; Region: COG1238 944546000032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546000033 S-adenosylmethionine binding site [chemical binding]; other site 944546000034 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 944546000035 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 944546000036 Walker A/P-loop; other site 944546000037 ATP binding site [chemical binding]; other site 944546000038 Q-loop/lid; other site 944546000039 ABC transporter signature motif; other site 944546000040 Walker B; other site 944546000041 D-loop; other site 944546000042 H-loop/switch region; other site 944546000043 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 944546000044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546000045 dimer interface [polypeptide binding]; other site 944546000046 conserved gate region; other site 944546000047 putative PBP binding loops; other site 944546000048 ABC-ATPase subunit interface; other site 944546000049 TOBE domain; Region: TOBE; cl01440 944546000050 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 944546000051 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 944546000052 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 944546000053 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 944546000054 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 944546000055 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 944546000056 Predicted membrane protein [Function unknown]; Region: COG3174 944546000057 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 944546000058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944546000059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944546000060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944546000061 dimerization interface [polypeptide binding]; other site 944546000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546000063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546000064 putative substrate translocation pore; other site 944546000065 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 944546000066 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944546000067 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944546000068 active site 944546000069 adenylosuccinate lyase; Provisional; Region: PRK08470 944546000070 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 944546000071 tetramer interface [polypeptide binding]; other site 944546000072 active site 944546000073 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 944546000074 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 944546000075 ATP cone domain; Region: ATP-cone; pfam03477 944546000076 Class I ribonucleotide reductase; Region: RNR_I; cd01679 944546000077 active site 944546000078 dimer interface [polypeptide binding]; other site 944546000079 catalytic residues [active] 944546000080 effector binding site; other site 944546000081 R2 peptide binding site; other site 944546000082 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 944546000083 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 944546000084 dimer interface [polypeptide binding]; other site 944546000085 putative radical transfer pathway; other site 944546000086 diiron center [ion binding]; other site 944546000087 tyrosyl radical; other site 944546000088 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 944546000089 Divergent AAA domain; Region: AAA_4; pfam04326 944546000090 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 944546000091 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944546000092 active site 944546000093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546000094 ligand binding site [chemical binding]; other site 944546000095 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546000096 Uncharacterized conserved protein [Function unknown]; Region: COG3743 944546000097 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 944546000098 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 944546000099 NADP binding site [chemical binding]; other site 944546000100 dimer interface [polypeptide binding]; other site 944546000101 Predicted transcriptional regulators [Transcription]; Region: COG1733 944546000102 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 944546000103 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 944546000104 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 944546000105 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 944546000106 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 944546000107 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 944546000108 GatB domain; Region: GatB_Yqey; smart00845 944546000109 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 944546000110 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 944546000111 FAD binding domain; Region: FAD_binding_4; pfam01565 944546000112 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944546000113 L-lactate permease; Region: Lactate_perm; cl00701 944546000114 glycolate transporter; Provisional; Region: PRK09695 944546000115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546000116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546000117 active site 944546000118 phosphorylation site [posttranslational modification] 944546000119 intermolecular recognition site; other site 944546000120 dimerization interface [polypeptide binding]; other site 944546000121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546000122 DNA binding site [nucleotide binding] 944546000123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 944546000124 PAS fold; Region: PAS_4; pfam08448 944546000125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546000126 putative active site [active] 944546000127 heme pocket [chemical binding]; other site 944546000128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546000129 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 944546000130 ATP binding site [chemical binding]; other site 944546000131 G-X-G motif; other site 944546000132 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944546000133 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 944546000134 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944546000135 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 944546000136 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944546000137 Cysteine-rich domain; Region: CCG; pfam02754 944546000138 Cysteine-rich domain; Region: CCG; pfam02754 944546000139 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 944546000140 catalytic motif [active] 944546000141 Zn binding site [ion binding]; other site 944546000142 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 944546000143 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944546000144 carboxyltransferase (CT) interaction site; other site 944546000145 biotinylation site [posttranslational modification]; other site 944546000146 biotin carboxylase; Validated; Region: PRK08462 944546000147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944546000148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944546000149 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 944546000150 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 944546000151 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944546000152 ATP binding site [chemical binding]; other site 944546000153 Mg++ binding site [ion binding]; other site 944546000154 motif III; other site 944546000155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546000156 nucleotide binding region [chemical binding]; other site 944546000157 ATP-binding site [chemical binding]; other site 944546000158 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 944546000159 Phosphate transporter family; Region: PHO4; pfam01384 944546000160 Phosphate transporter family; Region: PHO4; cl00396 944546000161 Membrane transport protein; Region: Mem_trans; cl09117 944546000162 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 944546000163 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 944546000164 active site 944546000165 dimer interface [polypeptide binding]; other site 944546000166 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 944546000167 Ligand Binding Site [chemical binding]; other site 944546000168 Molecular Tunnel; other site 944546000169 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 944546000170 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 944546000171 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 944546000172 putative active site [active] 944546000173 PhoH-like protein; Region: PhoH; pfam02562 944546000174 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 944546000175 recombination factor protein RarA; Reviewed; Region: PRK13342 944546000176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546000177 Walker A motif; other site 944546000178 ATP binding site [chemical binding]; other site 944546000179 Walker B motif; other site 944546000180 arginine finger; other site 944546000181 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 944546000182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546000183 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 944546000184 RNA binding surface [nucleotide binding]; other site 944546000185 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 944546000186 active site 944546000187 KpsF/GutQ family protein; Region: kpsF; TIGR00393 944546000188 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 944546000189 putative active site [active] 944546000190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 944546000191 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 944546000192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 944546000193 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 944546000194 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 944546000195 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 944546000196 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 944546000197 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 944546000198 substrate binding site [chemical binding]; other site 944546000199 glutamase interaction surface [polypeptide binding]; other site 944546000200 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 944546000201 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 944546000202 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 944546000203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 944546000204 FeS/SAM binding site; other site 944546000205 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944546000206 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 944546000207 active site 944546000208 HIGH motif; other site 944546000209 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944546000210 active site 944546000211 KMSKS motif; other site 944546000212 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 944546000213 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 944546000214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546000215 active site 944546000216 phosphorylation site [posttranslational modification] 944546000217 intermolecular recognition site; other site 944546000218 dimerization interface [polypeptide binding]; other site 944546000219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546000220 DNA binding site [nucleotide binding] 944546000221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546000222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546000223 dimer interface [polypeptide binding]; other site 944546000224 phosphorylation site [posttranslational modification] 944546000225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546000226 ATP binding site [chemical binding]; other site 944546000227 Mg2+ binding site [ion binding]; other site 944546000228 G-X-G motif; other site 944546000229 YtkA-like; Region: YtkA; pfam13115 944546000230 Outer membrane efflux protein; Region: OEP; pfam02321 944546000231 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 944546000232 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546000233 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 944546000234 Uncharacterized conserved protein [Function unknown]; Region: COG2353 944546000235 Domain of unknown function (DUF814); Region: DUF814; pfam05670 944546000236 Adhesion protein FadA; Region: FadA; pfam09403 944546000237 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 944546000238 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 944546000239 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 944546000240 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 944546000241 active site 944546000242 dimer interface [polypeptide binding]; other site 944546000243 motif 1; other site 944546000244 motif 2; other site 944546000245 motif 3; other site 944546000246 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 944546000247 anticodon binding site; other site 944546000248 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 944546000249 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 944546000250 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 944546000251 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 944546000252 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 944546000253 23S rRNA binding site [nucleotide binding]; other site 944546000254 L21 binding site [polypeptide binding]; other site 944546000255 L13 binding site [polypeptide binding]; other site 944546000256 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546000257 active site residue [active] 944546000258 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546000259 active site residue [active] 944546000260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546000261 active site residue [active] 944546000262 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 944546000263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944546000264 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 944546000265 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 944546000266 GTP binding site; other site 944546000267 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 944546000268 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 944546000269 substrate binding site [chemical binding]; other site 944546000270 ligand binding site [chemical binding]; other site 944546000271 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 944546000272 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 944546000273 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 944546000274 active site 944546000275 substrate binding site [chemical binding]; other site 944546000276 metal binding site [ion binding]; metal-binding site 944546000277 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 944546000278 peptide chain release factor 1; Validated; Region: prfA; PRK00591 944546000279 This domain is found in peptide chain release factors; Region: PCRF; smart00937 944546000280 RF-1 domain; Region: RF-1; pfam00472 944546000281 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 944546000282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546000283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 944546000284 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546000285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546000286 metal binding site [ion binding]; metal-binding site 944546000287 active site 944546000288 I-site; other site 944546000289 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 944546000290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546000291 dimer interface [polypeptide binding]; other site 944546000292 conserved gate region; other site 944546000293 putative PBP binding loops; other site 944546000294 ABC-ATPase subunit interface; other site 944546000295 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 944546000296 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 944546000297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546000298 dimer interface [polypeptide binding]; other site 944546000299 conserved gate region; other site 944546000300 putative PBP binding loops; other site 944546000301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 944546000302 ABC-ATPase subunit interface; other site 944546000303 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 944546000304 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 944546000305 Walker A/P-loop; other site 944546000306 ATP binding site [chemical binding]; other site 944546000307 Q-loop/lid; other site 944546000308 ABC transporter signature motif; other site 944546000309 Walker B; other site 944546000310 D-loop; other site 944546000311 H-loop/switch region; other site 944546000312 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 944546000313 PhoU domain; Region: PhoU; pfam01895 944546000314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546000315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546000316 active site 944546000317 phosphorylation site [posttranslational modification] 944546000318 intermolecular recognition site; other site 944546000319 dimerization interface [polypeptide binding]; other site 944546000320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546000321 DNA binding site [nucleotide binding] 944546000322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546000323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546000324 dimer interface [polypeptide binding]; other site 944546000325 phosphorylation site [posttranslational modification] 944546000326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546000327 ATP binding site [chemical binding]; other site 944546000328 Mg2+ binding site [ion binding]; other site 944546000329 G-X-G motif; other site 944546000330 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 944546000331 23S rRNA interface [nucleotide binding]; other site 944546000332 L3 interface [polypeptide binding]; other site 944546000333 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 944546000334 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 944546000335 peptide binding site [polypeptide binding]; other site 944546000336 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 944546000337 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 944546000338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546000339 motif II; other site 944546000340 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 944546000341 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 944546000342 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 944546000343 Protein of unknown function (DUF330); Region: DUF330; cl01135 944546000344 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 944546000345 mce related protein; Region: MCE; pfam02470 944546000346 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 944546000347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546000348 Walker A/P-loop; other site 944546000349 ATP binding site [chemical binding]; other site 944546000350 Q-loop/lid; other site 944546000351 ABC transporter signature motif; other site 944546000352 Walker B; other site 944546000353 D-loop; other site 944546000354 H-loop/switch region; other site 944546000355 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 944546000356 Permease; Region: Permease; pfam02405 944546000357 S-ribosylhomocysteinase; Provisional; Region: PRK02260 944546000358 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 944546000359 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 944546000360 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 944546000361 Predicted membrane protein [Function unknown]; Region: COG2259 944546000362 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 944546000363 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 944546000364 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 944546000365 substrate binding pocket [chemical binding]; other site 944546000366 dimer interface [polypeptide binding]; other site 944546000367 inhibitor binding site; inhibition site 944546000368 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 944546000369 B12 binding site [chemical binding]; other site 944546000370 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 944546000371 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 944546000372 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 944546000373 homodimer interface [polypeptide binding]; other site 944546000374 substrate-cofactor binding pocket; other site 944546000375 catalytic residue [active] 944546000376 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 944546000377 SPFH domain / Band 7 family; Region: Band_7; pfam01145 944546000378 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 944546000379 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 944546000380 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 944546000381 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 944546000382 metal binding site [ion binding]; metal-binding site 944546000383 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944546000384 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 944546000385 ThiC family; Region: ThiC; pfam01964 944546000386 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 944546000387 HDOD domain; Region: HDOD; pfam08668 944546000388 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 944546000389 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 944546000390 substrate binding site; other site 944546000391 dimer interface; other site 944546000392 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 944546000393 homotrimer interaction site [polypeptide binding]; other site 944546000394 zinc binding site [ion binding]; other site 944546000395 CDP-binding sites; other site 944546000396 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944546000397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546000398 active site 944546000399 phosphorylation site [posttranslational modification] 944546000400 dimerization interface [polypeptide binding]; other site 944546000401 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 944546000402 tetramer interfaces [polypeptide binding]; other site 944546000403 binuclear metal-binding site [ion binding]; other site 944546000404 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 944546000405 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 944546000406 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 944546000407 catalytic site [active] 944546000408 subunit interface [polypeptide binding]; other site 944546000409 Protein of unknown function (DUF507); Region: DUF507; pfam04368 944546000410 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 944546000411 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 944546000412 GDP-binding site [chemical binding]; other site 944546000413 ACT binding site; other site 944546000414 IMP binding site; other site 944546000415 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293 944546000416 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944546000417 motif 1; other site 944546000418 dimer interface [polypeptide binding]; other site 944546000419 active site 944546000420 motif 2; other site 944546000421 motif 3; other site 944546000422 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 944546000423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546000424 catalytic residue [active] 944546000425 Uncharacterized conserved protein [Function unknown]; Region: COG2353 944546000426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944546000427 MarR family; Region: MarR; pfam01047 944546000428 MarR family; Region: MarR_2; cl17246 944546000429 Uncharacterized conserved protein [Function unknown]; Region: COG2353 944546000430 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 944546000431 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 944546000432 putative active site [active] 944546000433 metal binding site [ion binding]; metal-binding site 944546000434 Predicted flavoprotein [General function prediction only]; Region: COG0431 944546000435 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 944546000436 Pirin-related protein [General function prediction only]; Region: COG1741 944546000437 Pirin; Region: Pirin; pfam02678 944546000438 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 944546000439 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 944546000440 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 944546000441 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 944546000442 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 944546000443 dimerization interface [polypeptide binding]; other site 944546000444 putative ATP binding site [chemical binding]; other site 944546000445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 944546000446 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 944546000447 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 944546000448 CoA-binding site [chemical binding]; other site 944546000449 ATP-binding [chemical binding]; other site 944546000450 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 944546000451 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 944546000452 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 944546000453 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 944546000454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944546000455 ATP-grasp domain; Region: ATP-grasp; pfam02222 944546000456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546000457 Coenzyme A binding pocket [chemical binding]; other site 944546000458 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944546000459 Sel1-like repeats; Region: SEL1; smart00671 944546000460 K+ potassium transporter; Region: K_trans; pfam02705 944546000461 prenyltransferase; Reviewed; Region: ubiA; PRK12874 944546000462 UbiA prenyltransferase family; Region: UbiA; pfam01040 944546000463 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 944546000464 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 944546000465 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 944546000466 Predicted methyltransferases [General function prediction only]; Region: COG0313 944546000467 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 944546000468 putative SAM binding site [chemical binding]; other site 944546000469 putative homodimer interface [polypeptide binding]; other site 944546000470 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 944546000471 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 944546000472 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 944546000473 aspartate aminotransferase; Provisional; Region: PRK08636 944546000474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546000475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546000476 homodimer interface [polypeptide binding]; other site 944546000477 catalytic residue [active] 944546000478 homoserine dehydrogenase; Provisional; Region: PRK06349 944546000479 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 944546000480 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 944546000481 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 944546000482 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 944546000483 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 944546000484 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 944546000485 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 944546000486 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 944546000487 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 944546000488 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 944546000489 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 944546000490 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 944546000491 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944546000492 UGMP family protein; Validated; Region: PRK09604 944546000493 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 944546000494 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 944546000495 putative rRNA binding site [nucleotide binding]; other site 944546000496 Uncharacterized conserved protein [Function unknown]; Region: COG0062 944546000497 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 944546000498 putative substrate binding site [chemical binding]; other site 944546000499 putative ATP binding site [chemical binding]; other site 944546000500 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 944546000501 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 944546000502 ThiS interaction site; other site 944546000503 putative active site [active] 944546000504 tetramer interface [polypeptide binding]; other site 944546000505 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 944546000506 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 944546000507 active site 944546000508 catalytic residues [active] 944546000509 metal binding site [ion binding]; metal-binding site 944546000510 homodimer binding site [polypeptide binding]; other site 944546000511 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 944546000512 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944546000513 carboxyltransferase (CT) interaction site; other site 944546000514 biotinylation site [posttranslational modification]; other site 944546000515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944546000516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546000517 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944546000518 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 944546000519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546000520 dimer interface [polypeptide binding]; other site 944546000521 putative CheW interface [polypeptide binding]; other site 944546000522 PLD-like domain; Region: PLDc_2; pfam13091 944546000523 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 944546000524 putative homodimer interface [polypeptide binding]; other site 944546000525 putative active site [active] 944546000526 catalytic site [active] 944546000527 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 944546000528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546000529 ATP binding site [chemical binding]; other site 944546000530 putative Mg++ binding site [ion binding]; other site 944546000531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546000532 nucleotide binding region [chemical binding]; other site 944546000533 ATP-binding site [chemical binding]; other site 944546000534 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 944546000535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546000536 putative substrate translocation pore; other site 944546000537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546000538 Transcriptional regulators [Transcription]; Region: MarR; COG1846 944546000539 MarR family; Region: MarR_2; pfam12802 944546000540 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 944546000541 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 944546000542 TPP-binding site [chemical binding]; other site 944546000543 dimer interface [polypeptide binding]; other site 944546000544 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 944546000545 PYR/PP interface [polypeptide binding]; other site 944546000546 dimer interface [polypeptide binding]; other site 944546000547 TPP binding site [chemical binding]; other site 944546000548 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944546000549 LrgA family; Region: LrgA; pfam03788 944546000550 LrgB-like family; Region: LrgB; pfam04172 944546000551 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 944546000552 putative active site pocket [active] 944546000553 dimerization interface [polypeptide binding]; other site 944546000554 putative catalytic residue [active] 944546000555 Predicted membrane protein [Function unknown]; Region: COG3766 944546000556 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 944546000557 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 944546000558 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 944546000559 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 944546000560 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 944546000561 DNA binding residues [nucleotide binding] 944546000562 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 944546000563 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 944546000564 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 944546000565 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944546000566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944546000567 putative acyl-acceptor binding pocket; other site 944546000568 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 944546000569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546000570 putative substrate translocation pore; other site 944546000571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944546000572 putative acyl-acceptor binding pocket; other site 944546000573 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 944546000574 acyl-activating enzyme (AAE) consensus motif; other site 944546000575 putative AMP binding site [chemical binding]; other site 944546000576 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944546000577 metal binding triad; other site 944546000578 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 944546000579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 944546000580 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 944546000581 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 944546000582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546000583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546000584 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546000585 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546000586 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546000587 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546000588 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546000589 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 944546000590 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 944546000591 Nitrogen regulatory protein P-II; Region: P-II; smart00938 944546000592 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 944546000593 active site 944546000594 substrate binding pocket [chemical binding]; other site 944546000595 dimer interface [polypeptide binding]; other site 944546000596 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 944546000597 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 944546000598 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 944546000599 Flagellar P-ring protein; Region: FlgI; pfam02119 944546000600 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 944546000601 Uncharacterized conserved protein [Function unknown]; Region: COG3334 944546000602 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 944546000603 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 944546000604 Flagellar L-ring protein; Region: FlgH; cl17277 944546000605 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 944546000606 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546000607 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 944546000608 flagellar protein FliS; Validated; Region: fliS; PRK05685 944546000609 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 944546000610 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 944546000611 Ligand Binding Site [chemical binding]; other site 944546000612 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 944546000613 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944546000614 pantoate--beta-alanine ligase; Region: panC; TIGR00018 944546000615 Pantoate-beta-alanine ligase; Region: PanC; cd00560 944546000616 active site 944546000617 ATP-binding site [chemical binding]; other site 944546000618 pantoate-binding site; other site 944546000619 HXXH motif; other site 944546000620 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 944546000621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546000622 dimer interface [polypeptide binding]; other site 944546000623 conserved gate region; other site 944546000624 putative PBP binding loops; other site 944546000625 ABC-ATPase subunit interface; other site 944546000626 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 944546000627 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 944546000628 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 944546000629 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 944546000630 FAD binding site [chemical binding]; other site 944546000631 phosphoserine phosphatase SerB; Region: serB; TIGR00338 944546000632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546000633 motif II; other site 944546000634 Class I aldolases; Region: Aldolase_Class_I; cl17187 944546000635 transaldolase; Provisional; Region: PRK03903 944546000636 catalytic residue [active] 944546000637 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 944546000638 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 944546000639 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 944546000640 ArsC family; Region: ArsC; pfam03960 944546000641 catalytic residue [active] 944546000642 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 944546000643 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 944546000644 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 944546000645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 944546000646 TrkA-C domain; Region: TrkA_C; pfam02080 944546000647 hypothetical protein; Provisional; Region: PRK05839 944546000648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546000649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546000650 homodimer interface [polypeptide binding]; other site 944546000651 catalytic residue [active] 944546000652 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 944546000653 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 944546000654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944546000655 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 944546000656 DNA protecting protein DprA; Region: dprA; TIGR00732 944546000657 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 944546000658 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 944546000659 putative active site [active] 944546000660 NodB motif; other site 944546000661 ketol-acid reductoisomerase; Provisional; Region: PRK05479 944546000662 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 944546000663 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 944546000664 Exoribonuclease R [Transcription]; Region: VacB; COG0557 944546000665 RNB domain; Region: RNB; pfam00773 944546000666 FliW protein; Region: FliW; pfam02623 944546000667 DNA polymerase III subunit delta; Validated; Region: PRK08487 944546000668 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 944546000669 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 944546000670 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 944546000671 dimer interface [polypeptide binding]; other site 944546000672 ssDNA binding site [nucleotide binding]; other site 944546000673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 944546000674 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 944546000675 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 944546000676 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 944546000677 active site 944546000678 HIGH motif; other site 944546000679 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 944546000680 KMSKS motif; other site 944546000681 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 944546000682 tRNA binding surface [nucleotide binding]; other site 944546000683 anticodon binding site; other site 944546000684 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 944546000685 NusA N-terminal domain; Region: NusA_N; pfam08529 944546000686 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 944546000687 RNA binding site [nucleotide binding]; other site 944546000688 homodimer interface [polypeptide binding]; other site 944546000689 NusA-like KH domain; Region: KH_5; pfam13184 944546000690 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 944546000691 G-X-X-G motif; other site 944546000692 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944546000693 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 944546000694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546000695 FeS/SAM binding site; other site 944546000696 TRAM domain; Region: TRAM; pfam01938 944546000697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 944546000698 putative acyl-acceptor binding pocket; other site 944546000699 hypothetical protein; Provisional; Region: PRK08444 944546000700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546000701 FeS/SAM binding site; other site 944546000702 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 944546000703 active site clefts [active] 944546000704 zinc binding site [ion binding]; other site 944546000705 dimer interface [polypeptide binding]; other site 944546000706 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 944546000707 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 944546000708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546000709 catalytic residue [active] 944546000710 hypothetical protein; Reviewed; Region: PRK12497 944546000711 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 944546000712 thiS-thiF/thiG interaction site; other site 944546000713 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546000714 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546000715 ligand binding site [chemical binding]; other site 944546000716 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 944546000717 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 944546000718 domain interfaces; other site 944546000719 active site 944546000720 acetylornithine aminotransferase; Provisional; Region: PRK02627 944546000721 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944546000722 inhibitor-cofactor binding pocket; inhibition site 944546000723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546000724 catalytic residue [active] 944546000725 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 944546000726 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 944546000727 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 944546000728 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 944546000729 para-aminobenzoate synthase component I; Validated; Region: PRK07093 944546000730 Isochorismatase family; Region: Isochorismatase; pfam00857 944546000731 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 944546000732 catalytic triad [active] 944546000733 conserved cis-peptide bond; other site 944546000734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546000735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546000736 active site 944546000737 phosphorylation site [posttranslational modification] 944546000738 dimerization interface [polypeptide binding]; other site 944546000739 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546000740 DNA binding site [nucleotide binding] 944546000741 hypothetical protein; Provisional; Region: PRK07101 944546000742 substrate-cofactor binding pocket; other site 944546000743 homodimer interface [polypeptide binding]; other site 944546000744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546000745 catalytic residue [active] 944546000746 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 944546000747 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 944546000748 PhnA protein; Region: PhnA; pfam03831 944546000749 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 944546000750 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944546000751 hypothetical protein; Provisional; Region: PRK10621 944546000752 HPP family; Region: HPP; pfam04982 944546000753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 944546000754 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 944546000755 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 944546000756 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546000757 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546000758 ligand binding site [chemical binding]; other site 944546000759 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 944546000760 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 944546000761 putative ligand binding site [chemical binding]; other site 944546000762 putative NAD binding site [chemical binding]; other site 944546000763 catalytic site [active] 944546000764 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 944546000765 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 944546000766 tetramer interface [polypeptide binding]; other site 944546000767 active site 944546000768 Mg2+/Mn2+ binding site [ion binding]; other site 944546000769 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 944546000770 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 944546000771 dimer interface [polypeptide binding]; other site 944546000772 active site 944546000773 citrylCoA binding site [chemical binding]; other site 944546000774 oxalacetate/citrate binding site [chemical binding]; other site 944546000775 coenzyme A binding site [chemical binding]; other site 944546000776 catalytic triad [active] 944546000777 aconitate hydratase; Validated; Region: PRK09277 944546000778 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 944546000779 substrate binding site [chemical binding]; other site 944546000780 ligand binding site [chemical binding]; other site 944546000781 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 944546000782 substrate binding site [chemical binding]; other site 944546000783 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 944546000784 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 944546000785 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 944546000786 catalytic triad [active] 944546000787 dimer interface [polypeptide binding]; other site 944546000788 Isochorismatase family; Region: Isochorismatase; pfam00857 944546000789 conserved cis-peptide bond; other site 944546000790 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 944546000791 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 944546000792 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 944546000793 domain interfaces; other site 944546000794 active site 944546000795 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 944546000796 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 944546000797 catalytic residues [active] 944546000798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546000799 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 944546000800 Walker A motif; other site 944546000801 ATP binding site [chemical binding]; other site 944546000802 Walker B motif; other site 944546000803 arginine finger; other site 944546000804 glutamate racemase; Provisional; Region: PRK00865 944546000805 glutamate dehydrogenase; Provisional; Region: PRK09414 944546000806 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 944546000807 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 944546000808 NAD(P) binding site [chemical binding]; other site 944546000809 transcription termination factor Rho; Provisional; Region: rho; PRK09376 944546000810 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 944546000811 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 944546000812 RNA binding site [nucleotide binding]; other site 944546000813 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 944546000814 multimer interface [polypeptide binding]; other site 944546000815 Walker A motif; other site 944546000816 ATP binding site [chemical binding]; other site 944546000817 Walker B motif; other site 944546000818 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 944546000819 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 944546000820 dimer interface [polypeptide binding]; other site 944546000821 decamer (pentamer of dimers) interface [polypeptide binding]; other site 944546000822 catalytic triad [active] 944546000823 peroxidatic and resolving cysteines [active] 944546000824 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944546000825 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 944546000826 active site 944546000827 multimer interface [polypeptide binding]; other site 944546000828 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 944546000829 putative phosphate acyltransferase; Provisional; Region: PRK05331 944546000830 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 944546000831 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 944546000832 dimer interface [polypeptide binding]; other site 944546000833 active site 944546000834 CoA binding pocket [chemical binding]; other site 944546000835 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 944546000836 GTP/Mg2+ binding site [chemical binding]; other site 944546000837 G5 box; other site 944546000838 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 944546000839 Dynamin family; Region: Dynamin_N; pfam00350 944546000840 G1 box; other site 944546000841 G1 box; other site 944546000842 GTP/Mg2+ binding site [chemical binding]; other site 944546000843 Switch I region; other site 944546000844 G2 box; other site 944546000845 G2 box; other site 944546000846 Switch I region; other site 944546000847 G3 box; other site 944546000848 Switch II region; other site 944546000849 G4 box; other site 944546000850 G5 box; other site 944546000851 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 944546000852 Dynamin family; Region: Dynamin_N; pfam00350 944546000853 G1 box; other site 944546000854 GTP/Mg2+ binding site [chemical binding]; other site 944546000855 G2 box; other site 944546000856 Switch I region; other site 944546000857 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 944546000858 G3 box; other site 944546000859 Switch II region; other site 944546000860 GTP/Mg2+ binding site [chemical binding]; other site 944546000861 G4 box; other site 944546000862 G5 box; other site 944546000863 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 944546000864 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 944546000865 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 944546000866 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 944546000867 L-aspartate oxidase; Provisional; Region: PRK06175 944546000868 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944546000869 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 944546000870 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 944546000871 Iron-sulfur protein interface; other site 944546000872 proximal heme binding site [chemical binding]; other site 944546000873 distal heme binding site [chemical binding]; other site 944546000874 dimer interface [polypeptide binding]; other site 944546000875 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 944546000876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944546000877 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 944546000878 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944546000879 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 944546000880 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 944546000881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 944546000882 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 944546000883 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 944546000884 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 944546000885 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 944546000886 4Fe-4S binding domain; Region: Fer4; pfam00037 944546000887 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 944546000888 NADH dehydrogenase; Region: NADHdh; cl00469 944546000889 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 944546000890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 944546000891 catalytic loop [active] 944546000892 iron binding site [ion binding]; other site 944546000893 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 944546000894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546000895 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546000896 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 944546000897 dimer interface [polypeptide binding]; other site 944546000898 Citrate synthase; Region: Citrate_synt; pfam00285 944546000899 active site 944546000900 citrylCoA binding site [chemical binding]; other site 944546000901 NADH binding [chemical binding]; other site 944546000902 cationic pore residues; other site 944546000903 oxalacetate/citrate binding site [chemical binding]; other site 944546000904 coenzyme A binding site [chemical binding]; other site 944546000905 catalytic triad [active] 944546000906 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 944546000907 SLBB domain; Region: SLBB; pfam10531 944546000908 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 944546000909 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 944546000910 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 944546000911 putative dimer interface [polypeptide binding]; other site 944546000912 [2Fe-2S] cluster binding site [ion binding]; other site 944546000913 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 944546000914 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 944546000915 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 944546000916 NADH dehydrogenase subunit B; Validated; Region: PRK06411 944546000917 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 944546000918 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 944546000919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546000920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546000921 homodimer interface [polypeptide binding]; other site 944546000922 catalytic residue [active] 944546000923 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 944546000924 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 944546000925 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 944546000926 Uncharacterized conserved protein [Function unknown]; Region: COG2966 944546000927 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 944546000928 pantothenate kinase; Reviewed; Region: PRK13333 944546000929 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 944546000930 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 944546000931 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944546000932 Methyltransferase domain; Region: Methyltransf_25; pfam13649 944546000933 S-adenosylmethionine binding site [chemical binding]; other site 944546000934 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546000935 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 944546000936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546000937 dimer interface [polypeptide binding]; other site 944546000938 putative CheW interface [polypeptide binding]; other site 944546000939 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 944546000940 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 944546000941 active site 944546000942 HIGH motif; other site 944546000943 dimer interface [polypeptide binding]; other site 944546000944 KMSKS motif; other site 944546000945 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 944546000946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546000947 N-terminal plug; other site 944546000948 ligand-binding site [chemical binding]; other site 944546000949 Predicted membrane protein [Function unknown]; Region: COG3503 944546000950 muropeptide transporter; Validated; Region: ampG; cl17669 944546000951 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944546000952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546000953 S-adenosylmethionine binding site [chemical binding]; other site 944546000954 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546000955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546000956 N-terminal plug; other site 944546000957 ligand-binding site [chemical binding]; other site 944546000958 Helix-turn-helix domain; Region: HTH_18; pfam12833 944546000959 Predicted membrane protein [Function unknown]; Region: COG1971 944546000960 Domain of unknown function DUF; Region: DUF204; pfam02659 944546000961 Domain of unknown function DUF; Region: DUF204; pfam02659 944546000962 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 944546000963 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944546000964 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 944546000965 putative metal binding site [ion binding]; other site 944546000966 putative homodimer interface [polypeptide binding]; other site 944546000967 putative homotetramer interface [polypeptide binding]; other site 944546000968 putative homodimer-homodimer interface [polypeptide binding]; other site 944546000969 putative allosteric switch controlling residues; other site 944546000970 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 944546000971 seryl-tRNA synthetase; Provisional; Region: PRK05431 944546000972 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 944546000973 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 944546000974 dimer interface [polypeptide binding]; other site 944546000975 active site 944546000976 motif 1; other site 944546000977 motif 2; other site 944546000978 motif 3; other site 944546000979 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 944546000980 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 944546000981 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 944546000982 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 944546000983 PAS fold; Region: PAS_4; pfam08448 944546000984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944546000985 putative active site [active] 944546000986 heme pocket [chemical binding]; other site 944546000987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546000988 metal binding site [ion binding]; metal-binding site 944546000989 active site 944546000990 I-site; other site 944546000991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546000992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546000993 PAS fold; Region: PAS_3; pfam08447 944546000994 putative active site [active] 944546000995 heme pocket [chemical binding]; other site 944546000996 NapD protein; Region: NapD; cl01163 944546000997 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 944546000998 structural tetrad; other site 944546000999 ferredoxin-type protein NapF; Region: napF; TIGR00402 944546001000 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 944546001001 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 944546001002 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944546001003 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944546001004 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944546001005 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 944546001006 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 944546001007 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546001008 molybdopterin cofactor binding site; other site 944546001009 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546001010 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546001011 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 944546001012 molybdopterin cofactor binding site; other site 944546001013 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 944546001014 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 944546001015 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 944546001016 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 944546001017 DctM-like transporters; Region: DctM; pfam06808 944546001018 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546001019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001021 ATP binding site [chemical binding]; other site 944546001022 Mg2+ binding site [ion binding]; other site 944546001023 G-X-G motif; other site 944546001024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001026 active site 944546001027 phosphorylation site [posttranslational modification] 944546001028 intermolecular recognition site; other site 944546001029 dimerization interface [polypeptide binding]; other site 944546001030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546001031 DNA binding site [nucleotide binding] 944546001032 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 944546001033 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 944546001034 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 944546001035 active site 944546001036 SAM binding site [chemical binding]; other site 944546001037 homodimer interface [polypeptide binding]; other site 944546001038 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 944546001039 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944546001040 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944546001041 ligand binding site [chemical binding]; other site 944546001042 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 944546001043 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 944546001044 hypothetical protein; Provisional; Region: PRK07394 944546001045 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 944546001046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546001047 FeS/SAM binding site; other site 944546001048 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 944546001049 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 944546001050 16S/18S rRNA binding site [nucleotide binding]; other site 944546001051 S13e-L30e interaction site [polypeptide binding]; other site 944546001052 25S rRNA binding site [nucleotide binding]; other site 944546001053 Rrf2 family protein; Region: rrf2_super; TIGR00738 944546001054 Transcriptional regulator; Region: Rrf2; pfam02082 944546001055 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 944546001056 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 944546001057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001058 HAMP domain; Region: HAMP; pfam00672 944546001059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546001060 dimer interface [polypeptide binding]; other site 944546001061 phosphorylation site [posttranslational modification] 944546001062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001063 ATP binding site [chemical binding]; other site 944546001064 Mg2+ binding site [ion binding]; other site 944546001065 G-X-G motif; other site 944546001066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001068 active site 944546001069 phosphorylation site [posttranslational modification] 944546001070 intermolecular recognition site; other site 944546001071 dimerization interface [polypeptide binding]; other site 944546001072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546001073 DNA binding site [nucleotide binding] 944546001074 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 944546001075 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 944546001076 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 944546001077 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 944546001078 active site 944546001079 intersubunit interface [polypeptide binding]; other site 944546001080 zinc binding site [ion binding]; other site 944546001081 Na+ binding site [ion binding]; other site 944546001082 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 944546001083 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 944546001084 NAD(P) binding site [chemical binding]; other site 944546001085 catalytic residues [active] 944546001086 Protein of unknown function (DUF779); Region: DUF779; cl01432 944546001087 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 944546001088 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944546001089 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 944546001090 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 944546001091 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 944546001092 catalytic residue [active] 944546001093 shikimate kinase; Reviewed; Region: aroK; PRK00131 944546001094 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 944546001095 ADP binding site [chemical binding]; other site 944546001096 magnesium binding site [ion binding]; other site 944546001097 putative shikimate binding site; other site 944546001098 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 944546001099 histidinol dehydrogenase; Region: hisD; TIGR00069 944546001100 NAD binding site [chemical binding]; other site 944546001101 dimerization interface [polypeptide binding]; other site 944546001102 product binding site; other site 944546001103 substrate binding site [chemical binding]; other site 944546001104 zinc binding site [ion binding]; other site 944546001105 catalytic residues [active] 944546001106 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 944546001107 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 944546001108 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 944546001109 substrate binding pocket [chemical binding]; other site 944546001110 chain length determination region; other site 944546001111 substrate-Mg2+ binding site; other site 944546001112 catalytic residues [active] 944546001113 aspartate-rich region 1; other site 944546001114 active site lid residues [active] 944546001115 aspartate-rich region 2; other site 944546001116 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 944546001117 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 944546001118 tRNA; other site 944546001119 putative tRNA binding site [nucleotide binding]; other site 944546001120 putative NADP binding site [chemical binding]; other site 944546001121 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 944546001122 prolyl-tRNA synthetase; Provisional; Region: PRK09194 944546001123 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944546001124 motif 1; other site 944546001125 dimer interface [polypeptide binding]; other site 944546001126 active site 944546001127 motif 2; other site 944546001128 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 944546001129 putative deacylase active site [active] 944546001130 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944546001131 active site 944546001132 motif 3; other site 944546001133 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 944546001134 anticodon binding site; other site 944546001135 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 944546001136 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944546001137 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 944546001138 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 944546001139 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 944546001140 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 944546001141 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 944546001142 active site 944546001143 catalytic triad [active] 944546001144 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 944546001145 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 944546001146 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 944546001147 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 944546001148 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 944546001149 Protein export membrane protein; Region: SecD_SecF; pfam02355 944546001150 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 944546001151 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 944546001152 ligand binding site [chemical binding]; other site 944546001153 flagellar motor protein MotA; Validated; Region: PRK08456 944546001154 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 944546001155 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 944546001156 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 944546001157 HIGH motif; other site 944546001158 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944546001159 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 944546001160 active site 944546001161 KMSKS motif; other site 944546001162 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 944546001163 tRNA binding surface [nucleotide binding]; other site 944546001164 Lipopolysaccharide-assembly; Region: LptE; pfam04390 944546001165 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 944546001166 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 944546001167 DEAD-like helicases superfamily; Region: DEXDc; smart00487 944546001168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546001169 ATP binding site [chemical binding]; other site 944546001170 putative Mg++ binding site [ion binding]; other site 944546001171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546001172 nucleotide binding region [chemical binding]; other site 944546001173 ATP-binding site [chemical binding]; other site 944546001174 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 944546001175 putative acyl-acceptor binding pocket; other site 944546001176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 944546001177 transferase, transferring glycosyl groups; Region: PLN02939 944546001178 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 944546001179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546001180 ATP binding site [chemical binding]; other site 944546001181 putative Mg++ binding site [ion binding]; other site 944546001182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546001183 nucleotide binding region [chemical binding]; other site 944546001184 ATP-binding site [chemical binding]; other site 944546001185 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 944546001186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 944546001187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546001188 Coenzyme A binding pocket [chemical binding]; other site 944546001189 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 944546001190 putative catalytic site [active] 944546001191 putative metal binding site [ion binding]; other site 944546001192 putative phosphate binding site [ion binding]; other site 944546001193 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 944546001194 dimer interface [polypeptide binding]; other site 944546001195 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001197 active site 944546001198 phosphorylation site [posttranslational modification] 944546001199 intermolecular recognition site; other site 944546001200 dimerization interface [polypeptide binding]; other site 944546001201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546001202 DNA binding site [nucleotide binding] 944546001203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 944546001205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001206 ATP binding site [chemical binding]; other site 944546001207 Mg2+ binding site [ion binding]; other site 944546001208 G-X-G motif; other site 944546001209 flavoprotein, HI0933 family; Region: TIGR00275 944546001210 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001211 dimer interface [polypeptide binding]; other site 944546001212 putative CheW interface [polypeptide binding]; other site 944546001213 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546001214 Response regulator receiver domain; Region: Response_reg; pfam00072 944546001215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001216 active site 944546001217 phosphorylation site [posttranslational modification] 944546001218 intermolecular recognition site; other site 944546001219 dimerization interface [polypeptide binding]; other site 944546001220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001221 PAS domain; Region: PAS_9; pfam13426 944546001222 putative active site [active] 944546001223 heme pocket [chemical binding]; other site 944546001224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001226 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 944546001227 putative active site [active] 944546001228 heme pocket [chemical binding]; other site 944546001229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001230 putative active site [active] 944546001231 heme pocket [chemical binding]; other site 944546001232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546001233 dimer interface [polypeptide binding]; other site 944546001234 phosphorylation site [posttranslational modification] 944546001235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001236 ATP binding site [chemical binding]; other site 944546001237 Mg2+ binding site [ion binding]; other site 944546001238 G-X-G motif; other site 944546001239 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 944546001240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944546001241 putative active site [active] 944546001242 metal binding site [ion binding]; metal-binding site 944546001243 homodimer binding site [polypeptide binding]; other site 944546001244 conjugal transfer protein TraL; Provisional; Region: PRK13886 944546001245 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 944546001246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546001247 S-adenosylmethionine binding site [chemical binding]; other site 944546001248 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 944546001249 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 944546001250 generic binding surface II; other site 944546001251 generic binding surface I; other site 944546001252 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 944546001253 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 944546001254 active site 944546001255 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 944546001256 tetramerization interface [polypeptide binding]; other site 944546001257 active site 944546001258 hypothetical protein; Provisional; Region: PRK03762 944546001259 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 944546001260 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 944546001261 substrate binding pocket [chemical binding]; other site 944546001262 chain length determination region; other site 944546001263 substrate-Mg2+ binding site; other site 944546001264 catalytic residues [active] 944546001265 aspartate-rich region 1; other site 944546001266 active site lid residues [active] 944546001267 aspartate-rich region 2; other site 944546001268 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 944546001269 oligomerisation interface [polypeptide binding]; other site 944546001270 mobile loop; other site 944546001271 roof hairpin; other site 944546001272 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 944546001273 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 944546001274 ring oligomerisation interface [polypeptide binding]; other site 944546001275 ATP/Mg binding site [chemical binding]; other site 944546001276 stacking interactions; other site 944546001277 hinge regions; other site 944546001278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546001279 dimer interface [polypeptide binding]; other site 944546001280 phosphorylation site [posttranslational modification] 944546001281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001282 ATP binding site [chemical binding]; other site 944546001283 G-X-G motif; other site 944546001284 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 944546001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001286 active site 944546001287 phosphorylation site [posttranslational modification] 944546001288 intermolecular recognition site; other site 944546001289 dimerization interface [polypeptide binding]; other site 944546001290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546001291 DNA binding site [nucleotide binding] 944546001292 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 944546001293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944546001294 putative active site [active] 944546001295 putative metal binding site [ion binding]; other site 944546001296 YceI-like domain; Region: YceI; pfam04264 944546001297 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546001298 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944546001299 Walker A/P-loop; other site 944546001300 ATP binding site [chemical binding]; other site 944546001301 Q-loop/lid; other site 944546001302 ABC transporter signature motif; other site 944546001303 Walker B; other site 944546001304 D-loop; other site 944546001305 H-loop/switch region; other site 944546001306 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 944546001307 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 944546001308 FtsX-like permease family; Region: FtsX; pfam02687 944546001309 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 944546001310 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 944546001311 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 944546001312 active site 944546001313 dimerization interface [polypeptide binding]; other site 944546001314 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 944546001315 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 944546001316 glutaminase active site [active] 944546001317 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 944546001318 dimer interface [polypeptide binding]; other site 944546001319 active site 944546001320 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 944546001321 dimer interface [polypeptide binding]; other site 944546001322 active site 944546001323 S-adenosylmethionine synthetase; Validated; Region: PRK05250 944546001324 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 944546001325 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 944546001326 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 944546001327 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 944546001328 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 944546001329 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 944546001330 thiamine phosphate binding site [chemical binding]; other site 944546001331 active site 944546001332 pyrophosphate binding site [ion binding]; other site 944546001333 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 944546001334 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 944546001335 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 944546001336 FMN binding site [chemical binding]; other site 944546001337 active site 944546001338 catalytic residues [active] 944546001339 substrate binding site [chemical binding]; other site 944546001340 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 944546001341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546001342 S-adenosylmethionine binding site [chemical binding]; other site 944546001343 FtsH Extracellular; Region: FtsH_ext; pfam06480 944546001344 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 944546001345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546001346 Walker A motif; other site 944546001347 ATP binding site [chemical binding]; other site 944546001348 Walker B motif; other site 944546001349 arginine finger; other site 944546001350 Peptidase family M41; Region: Peptidase_M41; pfam01434 944546001351 Response regulator receiver domain; Region: Response_reg; pfam00072 944546001352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001353 active site 944546001354 phosphorylation site [posttranslational modification] 944546001355 intermolecular recognition site; other site 944546001356 dimerization interface [polypeptide binding]; other site 944546001357 PAS domain; Region: PAS_9; pfam13426 944546001358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001359 putative active site [active] 944546001360 heme pocket [chemical binding]; other site 944546001361 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 944546001362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001363 putative active site [active] 944546001364 heme pocket [chemical binding]; other site 944546001365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546001366 Zn2+ binding site [ion binding]; other site 944546001367 Mg2+ binding site [ion binding]; other site 944546001368 Response regulator receiver domain; Region: Response_reg; pfam00072 944546001369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001370 active site 944546001371 phosphorylation site [posttranslational modification] 944546001372 intermolecular recognition site; other site 944546001373 dimerization interface [polypeptide binding]; other site 944546001374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944546001376 dimerization interface [polypeptide binding]; other site 944546001377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546001378 dimer interface [polypeptide binding]; other site 944546001379 phosphorylation site [posttranslational modification] 944546001380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001381 ATP binding site [chemical binding]; other site 944546001382 Mg2+ binding site [ion binding]; other site 944546001383 G-X-G motif; other site 944546001384 2-isopropylmalate synthase; Validated; Region: PRK00915 944546001385 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 944546001386 active site 944546001387 catalytic residues [active] 944546001388 metal binding site [ion binding]; metal-binding site 944546001389 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 944546001390 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944546001391 catalytic residues [active] 944546001392 Haem-binding domain; Region: Haem_bd; pfam14376 944546001393 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 944546001394 MutS domain I; Region: MutS_I; pfam01624 944546001395 MutS domain III; Region: MutS_III; pfam05192 944546001396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546001397 Walker A/P-loop; other site 944546001398 ATP binding site [chemical binding]; other site 944546001399 Q-loop/lid; other site 944546001400 ABC transporter signature motif; other site 944546001401 Walker B; other site 944546001402 D-loop; other site 944546001403 H-loop/switch region; other site 944546001404 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 944546001405 active site 944546001406 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944546001407 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546001408 Outer membrane efflux protein; Region: OEP; pfam02321 944546001409 Outer membrane efflux protein; Region: OEP; pfam02321 944546001410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944546001411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944546001412 Helix-turn-helix domain; Region: HTH_18; pfam12833 944546001413 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 944546001414 Cytochrome c; Region: Cytochrom_C; pfam00034 944546001415 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 944546001416 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 944546001417 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 944546001418 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 944546001419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546001420 FeS/SAM binding site; other site 944546001421 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 944546001422 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 944546001423 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 944546001424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944546001425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 944546001426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546001427 Walker A/P-loop; other site 944546001428 ATP binding site [chemical binding]; other site 944546001429 ABC transporter signature motif; other site 944546001430 Walker B; other site 944546001431 D-loop; other site 944546001432 H-loop/switch region; other site 944546001433 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 944546001434 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 944546001435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546001436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546001437 metal binding site [ion binding]; metal-binding site 944546001438 active site 944546001439 I-site; other site 944546001440 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 944546001441 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 944546001442 catalytic residues [active] 944546001443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546001444 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 944546001445 NAD(P) binding site [chemical binding]; other site 944546001446 active site 944546001447 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 944546001448 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 944546001449 putative active site [active] 944546001450 oxyanion strand; other site 944546001451 catalytic triad [active] 944546001452 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 944546001453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546001454 active site 944546001455 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 944546001456 GTP-binding protein LepA; Provisional; Region: PRK05433 944546001457 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 944546001458 G1 box; other site 944546001459 putative GEF interaction site [polypeptide binding]; other site 944546001460 GTP/Mg2+ binding site [chemical binding]; other site 944546001461 Switch I region; other site 944546001462 G2 box; other site 944546001463 G3 box; other site 944546001464 Switch II region; other site 944546001465 G4 box; other site 944546001466 G5 box; other site 944546001467 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 944546001468 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 944546001469 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 944546001470 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 944546001471 putative homodimer interface [polypeptide binding]; other site 944546001472 putative homotetramer interface [polypeptide binding]; other site 944546001473 putative allosteric switch controlling residues; other site 944546001474 putative metal binding site [ion binding]; other site 944546001475 putative homodimer-homodimer interface [polypeptide binding]; other site 944546001476 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 944546001477 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944546001478 metal-binding site [ion binding] 944546001479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944546001480 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944546001481 metal-binding site [ion binding] 944546001482 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 944546001483 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546001484 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546001485 ligand binding site [chemical binding]; other site 944546001486 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 944546001487 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 944546001488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546001489 active site 944546001490 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 944546001491 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 944546001492 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 944546001493 Ligand Binding Site [chemical binding]; other site 944546001494 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 944546001495 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 944546001496 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 944546001497 catalytic center binding site [active] 944546001498 ATP binding site [chemical binding]; other site 944546001499 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 944546001500 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 944546001501 active site 944546001502 Dehydroquinase class II; Region: DHquinase_II; pfam01220 944546001503 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 944546001504 trimer interface [polypeptide binding]; other site 944546001505 active site 944546001506 dimer interface [polypeptide binding]; other site 944546001507 chlorohydrolase; Provisional; Region: PRK08418 944546001508 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 944546001509 active site 944546001510 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 944546001511 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 944546001512 tandem repeat interface [polypeptide binding]; other site 944546001513 oligomer interface [polypeptide binding]; other site 944546001514 active site residues [active] 944546001515 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944546001516 propionate/acetate kinase; Provisional; Region: PRK12379 944546001517 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 944546001518 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944546001519 propionate/acetate kinase; Provisional; Region: PRK12379 944546001520 Cation efflux family; Region: Cation_efflux; cl00316 944546001521 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 944546001522 propionate/acetate kinase; Provisional; Region: PRK12379 944546001523 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944546001524 active site 944546001525 catalytic site [active] 944546001526 substrate binding site [chemical binding]; other site 944546001527 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 944546001528 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944546001529 ligand binding site [chemical binding]; other site 944546001530 flexible hinge region; other site 944546001531 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944546001532 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944546001533 metal binding triad; other site 944546001534 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944546001535 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 944546001536 Na binding site [ion binding]; other site 944546001537 Protein of unknown function, DUF485; Region: DUF485; pfam04341 944546001538 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 944546001539 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944546001540 Na binding site [ion binding]; other site 944546001541 Protein of unknown function, DUF485; Region: DUF485; pfam04341 944546001542 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 944546001543 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944546001544 active site 944546001545 catalytic site [active] 944546001546 substrate binding site [chemical binding]; other site 944546001547 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 944546001548 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944546001549 ligand binding site [chemical binding]; other site 944546001550 flexible hinge region; other site 944546001551 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944546001552 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 944546001553 metal binding triad; other site 944546001554 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 944546001555 Na binding site [ion binding]; other site 944546001556 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 944546001557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001559 active site 944546001560 phosphorylation site [posttranslational modification] 944546001561 intermolecular recognition site; other site 944546001562 dimerization interface [polypeptide binding]; other site 944546001563 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546001564 DNA binding site [nucleotide binding] 944546001565 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546001566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546001568 dimer interface [polypeptide binding]; other site 944546001569 phosphorylation site [posttranslational modification] 944546001570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001571 ATP binding site [chemical binding]; other site 944546001572 Mg2+ binding site [ion binding]; other site 944546001573 G-X-G motif; other site 944546001574 Competence-damaged protein; Region: CinA; pfam02464 944546001575 Predicted dehydrogenase [General function prediction only]; Region: COG0579 944546001576 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 944546001577 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 944546001578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944546001579 active site 944546001580 HIGH motif; other site 944546001581 nucleotide binding site [chemical binding]; other site 944546001582 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944546001583 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 944546001584 active site 944546001585 KMSKS motif; other site 944546001586 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 944546001587 tRNA binding surface [nucleotide binding]; other site 944546001588 anticodon binding site; other site 944546001589 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 944546001590 NifU-like domain; Region: NifU; cl00484 944546001591 Protein of unknown function DUF89; Region: DUF89; cl15397 944546001592 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 944546001593 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944546001594 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 944546001595 haemagglutination activity domain; Region: Haemagg_act; smart00912 944546001596 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 944546001597 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 944546001598 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 944546001599 haemagglutination activity domain; Region: Haemagg_act; smart00912 944546001600 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 944546001601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001603 active site 944546001604 phosphorylation site [posttranslational modification] 944546001605 intermolecular recognition site; other site 944546001606 dimerization interface [polypeptide binding]; other site 944546001607 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546001608 DNA binding site [nucleotide binding] 944546001609 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 944546001610 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944546001611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944546001612 Histidine kinase; Region: HisKA_2; pfam07568 944546001613 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 944546001614 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 944546001615 gating phenylalanine in ion channel; other site 944546001616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 944546001617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 944546001618 active site 944546001619 catalytic tetrad [active] 944546001620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 944546001621 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 944546001622 HAMP domain; Region: HAMP; pfam00672 944546001623 dimerization interface [polypeptide binding]; other site 944546001624 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001625 dimer interface [polypeptide binding]; other site 944546001626 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546001627 putative CheW interface [polypeptide binding]; other site 944546001628 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546001629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001630 dimer interface [polypeptide binding]; other site 944546001631 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546001632 putative CheW interface [polypeptide binding]; other site 944546001633 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 944546001634 active site 944546001635 nuclease NucT; Provisional; Region: PRK13912 944546001636 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 944546001637 putative active site [active] 944546001638 catalytic site [active] 944546001639 Peptidase family M48; Region: Peptidase_M48; pfam01435 944546001640 RmuC family; Region: RmuC; pfam02646 944546001641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944546001642 EamA-like transporter family; Region: EamA; pfam00892 944546001643 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 944546001644 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 944546001645 dimer interface [polypeptide binding]; other site 944546001646 putative functional site; other site 944546001647 putative MPT binding site; other site 944546001648 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 944546001649 Ligand Binding Site [chemical binding]; other site 944546001650 Uncharacterized conserved protein [Function unknown]; Region: COG1683 944546001651 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 944546001652 SprA-related family; Region: SprA-related; pfam12118 944546001653 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 944546001654 rRNA interaction site [nucleotide binding]; other site 944546001655 S8 interaction site; other site 944546001656 putative laminin-1 binding site; other site 944546001657 elongation factor Ts; Provisional; Region: tsf; PRK09377 944546001658 UBA/TS-N domain; Region: UBA; pfam00627 944546001659 Elongation factor TS; Region: EF_TS; pfam00889 944546001660 Elongation factor TS; Region: EF_TS; pfam00889 944546001661 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546001662 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944546001663 Walker A/P-loop; other site 944546001664 ATP binding site [chemical binding]; other site 944546001665 Q-loop/lid; other site 944546001666 ABC transporter signature motif; other site 944546001667 Walker B; other site 944546001668 D-loop; other site 944546001669 H-loop/switch region; other site 944546001670 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 944546001671 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 944546001672 catalytic site [active] 944546001673 G-X2-G-X-G-K; other site 944546001674 Response regulator receiver domain; Region: Response_reg; pfam00072 944546001675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001676 active site 944546001677 phosphorylation site [posttranslational modification] 944546001678 intermolecular recognition site; other site 944546001679 dimerization interface [polypeptide binding]; other site 944546001680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546001681 metal binding site [ion binding]; metal-binding site 944546001682 active site 944546001683 I-site; other site 944546001684 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546001685 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 944546001686 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 944546001687 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944546001688 metal-binding site [ion binding] 944546001689 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944546001690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546001691 motif II; other site 944546001692 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 944546001693 Cytochrome c; Region: Cytochrom_C; cl11414 944546001694 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546001695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 944546001696 Walker A/P-loop; other site 944546001697 ATP binding site [chemical binding]; other site 944546001698 Q-loop/lid; other site 944546001699 ABC transporter signature motif; other site 944546001700 Walker B; other site 944546001701 D-loop; other site 944546001702 H-loop/switch region; other site 944546001703 ferrochelatase; Reviewed; Region: hemH; PRK00035 944546001704 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 944546001705 C-terminal domain interface [polypeptide binding]; other site 944546001706 active site 944546001707 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 944546001708 active site 944546001709 N-terminal domain interface [polypeptide binding]; other site 944546001710 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 944546001711 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 944546001712 G1 box; other site 944546001713 GTP/Mg2+ binding site [chemical binding]; other site 944546001714 G2 box; other site 944546001715 Switch I region; other site 944546001716 G3 box; other site 944546001717 Switch II region; other site 944546001718 G4 box; other site 944546001719 G5 box; other site 944546001720 Nucleoside recognition; Region: Gate; pfam07670 944546001721 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 944546001722 Nucleoside recognition; Region: Gate; pfam07670 944546001723 FeoA domain; Region: FeoA; pfam04023 944546001724 Uncharacterized conserved protein [Function unknown]; Region: COG1434 944546001725 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 944546001726 putative active site [active] 944546001727 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546001728 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 944546001729 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 944546001730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 944546001731 dimer interface [polypeptide binding]; other site 944546001732 putative PBP binding regions; other site 944546001733 ABC-ATPase subunit interface; other site 944546001734 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 944546001735 S1 domain; Region: S1_2; pfam13509 944546001736 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 944546001737 dimer interface [polypeptide binding]; other site 944546001738 catalytic triad [active] 944546001739 peroxidatic and resolving cysteines [active] 944546001740 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944546001741 Sel1-like repeats; Region: SEL1; smart00671 944546001742 Sel1-like repeats; Region: SEL1; smart00671 944546001743 Sel1-like repeats; Region: SEL1; smart00671 944546001744 Sel1-like repeats; Region: SEL1; smart00671 944546001745 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 944546001746 NnrS protein; Region: NnrS; pfam05940 944546001747 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 944546001748 Part of AAA domain; Region: AAA_19; pfam13245 944546001749 Family description; Region: UvrD_C_2; pfam13538 944546001750 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944546001751 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944546001752 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 944546001753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944546001754 active site 944546001755 HIGH motif; other site 944546001756 nucleotide binding site [chemical binding]; other site 944546001757 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 944546001758 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 944546001759 active site 944546001760 KMSKS motif; other site 944546001761 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 944546001762 tRNA binding surface [nucleotide binding]; other site 944546001763 anticodon binding site; other site 944546001764 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 944546001765 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 944546001766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546001767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546001768 putative substrate translocation pore; other site 944546001769 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 944546001770 active site 944546001771 dimerization interface [polypeptide binding]; other site 944546001772 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 944546001773 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 944546001774 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 944546001775 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 944546001776 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 944546001777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546001778 Walker A motif; other site 944546001779 ATP binding site [chemical binding]; other site 944546001780 Walker B motif; other site 944546001781 arginine finger; other site 944546001782 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 944546001783 Rhomboid family; Region: Rhomboid; pfam01694 944546001784 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 944546001785 Low molecular weight phosphatase family; Region: LMWPc; cd00115 944546001786 active site 944546001787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 944546001788 Tetratricopeptide repeat; Region: TPR_12; pfam13424 944546001789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546001790 binding surface 944546001791 TPR motif; other site 944546001792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546001793 binding surface 944546001794 TPR motif; other site 944546001795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 944546001796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 944546001797 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944546001798 MarR family; Region: MarR; pfam01047 944546001799 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 944546001800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944546001801 non-specific DNA binding site [nucleotide binding]; other site 944546001802 salt bridge; other site 944546001803 sequence-specific DNA binding site [nucleotide binding]; other site 944546001804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001805 PAS fold; Region: PAS_3; pfam08447 944546001806 putative active site [active] 944546001807 heme pocket [chemical binding]; other site 944546001808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001809 dimer interface [polypeptide binding]; other site 944546001810 putative CheW interface [polypeptide binding]; other site 944546001811 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 944546001812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001813 putative active site [active] 944546001814 heme pocket [chemical binding]; other site 944546001815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001816 putative active site [active] 944546001817 heme pocket [chemical binding]; other site 944546001818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001819 dimer interface [polypeptide binding]; other site 944546001820 putative CheW interface [polypeptide binding]; other site 944546001821 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 944546001822 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 944546001823 EamA-like transporter family; Region: EamA; pfam00892 944546001824 YceI-like domain; Region: YceI; cl01001 944546001825 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 944546001826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944546001827 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 944546001828 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 944546001829 Domain of unknown function DUF59; Region: DUF59; cl00941 944546001830 Fe-S metabolism associated domain; Region: SufE; cl00951 944546001831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 944546001832 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 944546001833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546001834 catalytic residue [active] 944546001835 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 944546001836 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 944546001837 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 944546001838 FeS assembly ATPase SufC; Region: sufC; TIGR01978 944546001839 Walker A/P-loop; other site 944546001840 ATP binding site [chemical binding]; other site 944546001841 Q-loop/lid; other site 944546001842 ABC transporter signature motif; other site 944546001843 Walker B; other site 944546001844 D-loop; other site 944546001845 H-loop/switch region; other site 944546001846 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 944546001847 putative ABC transporter; Region: ycf24; CHL00085 944546001848 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546001849 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 944546001850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546001851 catalytic residue [active] 944546001852 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 944546001853 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 944546001854 trimerization site [polypeptide binding]; other site 944546001855 active site 944546001856 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944546001857 NifU-like domain; Region: NifU; cl00484 944546001858 FOG: CBS domain [General function prediction only]; Region: COG0517 944546001859 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 944546001860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546001861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546001862 metal binding site [ion binding]; metal-binding site 944546001863 active site 944546001864 I-site; other site 944546001865 argininosuccinate lyase; Provisional; Region: PRK00855 944546001866 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 944546001867 active sites [active] 944546001868 tetramer interface [polypeptide binding]; other site 944546001869 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 944546001870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944546001871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001872 active site 944546001873 phosphorylation site [posttranslational modification] 944546001874 intermolecular recognition site; other site 944546001875 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 944546001876 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 944546001877 putative ATP binding site [chemical binding]; other site 944546001878 putative substrate interface [chemical binding]; other site 944546001879 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 944546001880 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 944546001881 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 944546001882 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 944546001883 putative active site [active] 944546001884 putative metal binding site [ion binding]; other site 944546001885 excinuclease ABC subunit B; Provisional; Region: PRK05298 944546001886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546001887 ATP binding site [chemical binding]; other site 944546001888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546001889 nucleotide binding region [chemical binding]; other site 944546001890 ATP-binding site [chemical binding]; other site 944546001891 Ultra-violet resistance protein B; Region: UvrB; pfam12344 944546001892 UvrB/uvrC motif; Region: UVR; pfam02151 944546001893 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001894 dimer interface [polypeptide binding]; other site 944546001895 putative CheW interface [polypeptide binding]; other site 944546001896 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 944546001897 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 944546001898 minor groove reading motif; other site 944546001899 helix-hairpin-helix signature motif; other site 944546001900 substrate binding pocket [chemical binding]; other site 944546001901 active site 944546001902 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546001903 N-terminal plug; other site 944546001904 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 944546001905 ligand-binding site [chemical binding]; other site 944546001906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546001907 N-terminal plug; other site 944546001908 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 944546001909 ligand-binding site [chemical binding]; other site 944546001910 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546001911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001912 dimer interface [polypeptide binding]; other site 944546001913 putative CheW interface [polypeptide binding]; other site 944546001914 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 944546001915 active site 944546001916 GIY-YIG motif/motif A; other site 944546001917 catalytic site [active] 944546001918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546001919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546001920 active site 944546001921 phosphorylation site [posttranslational modification] 944546001922 intermolecular recognition site; other site 944546001923 dimerization interface [polypeptide binding]; other site 944546001924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546001925 DNA binding site [nucleotide binding] 944546001926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546001927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546001928 ATP binding site [chemical binding]; other site 944546001929 Mg2+ binding site [ion binding]; other site 944546001930 G-X-G motif; other site 944546001931 PAS domain; Region: PAS_9; pfam13426 944546001932 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 944546001933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546001934 putative active site [active] 944546001935 heme pocket [chemical binding]; other site 944546001936 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546001937 dimer interface [polypeptide binding]; other site 944546001938 putative CheW interface [polypeptide binding]; other site 944546001939 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 944546001940 HD domain; Region: HD_3; pfam13023 944546001941 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 944546001942 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 944546001943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546001944 Coenzyme A binding pocket [chemical binding]; other site 944546001945 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 944546001946 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 944546001947 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 944546001948 Catalytic site [active] 944546001949 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 944546001950 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 944546001951 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 944546001952 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 944546001953 homodimer interface [polypeptide binding]; other site 944546001954 NADP binding site [chemical binding]; other site 944546001955 substrate binding site [chemical binding]; other site 944546001956 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 944546001957 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 944546001958 5S rRNA interface [nucleotide binding]; other site 944546001959 CTC domain interface [polypeptide binding]; other site 944546001960 L16 interface [polypeptide binding]; other site 944546001961 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 944546001962 putative active site [active] 944546001963 catalytic residue [active] 944546001964 Predicted permeases [General function prediction only]; Region: COG0795 944546001965 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 944546001966 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 944546001967 nudix motif; other site 944546001968 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 944546001969 nudix motif; other site 944546001970 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 944546001971 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 944546001972 active site 944546001973 metal binding site [ion binding]; metal-binding site 944546001974 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 944546001975 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 944546001976 FMN binding site [chemical binding]; other site 944546001977 substrate binding site [chemical binding]; other site 944546001978 putative catalytic residue [active] 944546001979 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 944546001980 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 944546001981 active site 944546001982 HIGH motif; other site 944546001983 dimer interface [polypeptide binding]; other site 944546001984 KMSKS motif; other site 944546001985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546001986 RNA binding surface [nucleotide binding]; other site 944546001987 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 944546001988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546001989 Zn2+ binding site [ion binding]; other site 944546001990 Mg2+ binding site [ion binding]; other site 944546001991 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 944546001992 synthetase active site [active] 944546001993 NTP binding site [chemical binding]; other site 944546001994 metal binding site [ion binding]; metal-binding site 944546001995 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 944546001996 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 944546001997 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 944546001998 putative nucleotide binding site [chemical binding]; other site 944546001999 uridine monophosphate binding site [chemical binding]; other site 944546002000 homohexameric interface [polypeptide binding]; other site 944546002001 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 944546002002 AAA domain; Region: AAA_14; pfam13173 944546002003 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 944546002004 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 944546002005 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 944546002006 active site 944546002007 hydrophilic channel; other site 944546002008 dimerization interface [polypeptide binding]; other site 944546002009 catalytic residues [active] 944546002010 active site lid [active] 944546002011 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 944546002012 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 944546002013 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 944546002014 Sporulation related domain; Region: SPOR; pfam05036 944546002015 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 944546002016 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 944546002017 dimer interface [polypeptide binding]; other site 944546002018 active site 944546002019 glycine-pyridoxal phosphate binding site [chemical binding]; other site 944546002020 folate binding site [chemical binding]; other site 944546002021 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 944546002022 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 944546002023 dimer interface [polypeptide binding]; other site 944546002024 putative anticodon binding site; other site 944546002025 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 944546002026 motif 1; other site 944546002027 active site 944546002028 motif 2; other site 944546002029 motif 3; other site 944546002030 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 944546002031 Colicin V production protein; Region: Colicin_V; pfam02674 944546002032 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 944546002033 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 944546002034 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 944546002035 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546002036 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546002037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546002038 metal binding site [ion binding]; metal-binding site 944546002039 active site 944546002040 I-site; other site 944546002041 replicative DNA helicase; Provisional; Region: PRK08506 944546002042 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 944546002043 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 944546002044 Walker A motif; other site 944546002045 ATP binding site [chemical binding]; other site 944546002046 Walker B motif; other site 944546002047 DNA binding loops [nucleotide binding] 944546002048 Chain length determinant protein; Region: Wzz; cl15801 944546002049 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944546002050 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 944546002051 NAD(P) binding site [chemical binding]; other site 944546002052 homodimer interface [polypeptide binding]; other site 944546002053 substrate binding site [chemical binding]; other site 944546002054 active site 944546002055 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 944546002056 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 944546002057 inhibitor-cofactor binding pocket; inhibition site 944546002058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546002059 catalytic residue [active] 944546002060 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 944546002061 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 944546002062 putative trimer interface [polypeptide binding]; other site 944546002063 putative CoA binding site [chemical binding]; other site 944546002064 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 944546002065 NeuB family; Region: NeuB; pfam03102 944546002066 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 944546002067 NeuB binding interface [polypeptide binding]; other site 944546002068 putative substrate binding site [chemical binding]; other site 944546002069 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 944546002070 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 944546002071 active site 944546002072 homodimer interface [polypeptide binding]; other site 944546002073 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 944546002074 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 944546002075 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 944546002076 Substrate binding site; other site 944546002077 metal-binding site 944546002078 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 944546002079 ligand binding site; other site 944546002080 tetramer interface; other site 944546002081 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 944546002082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546002083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546002084 catalytic residue [active] 944546002085 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 944546002086 Ligand Binding Site [chemical binding]; other site 944546002087 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 944546002088 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 944546002089 putative active site [active] 944546002090 oxyanion strand; other site 944546002091 catalytic triad [active] 944546002092 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 944546002093 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 944546002094 substrate binding site [chemical binding]; other site 944546002095 glutamase interaction surface [polypeptide binding]; other site 944546002096 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 944546002097 putative trimer interface [polypeptide binding]; other site 944546002098 putative CoA binding site [chemical binding]; other site 944546002099 Predicted amidohydrolase [General function prediction only]; Region: COG0388 944546002100 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 944546002101 putative active site [active] 944546002102 catalytic triad [active] 944546002103 putative dimer interface [polypeptide binding]; other site 944546002104 flagellin modification protein A; Provisional; Region: PRK09186 944546002105 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 944546002106 putative NAD(P) binding site [chemical binding]; other site 944546002107 active site 944546002108 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 944546002109 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546002110 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 944546002111 trimer interface [polypeptide binding]; other site 944546002112 active site 944546002113 substrate binding site [chemical binding]; other site 944546002114 CoA binding site [chemical binding]; other site 944546002115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 944546002116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546002117 NAD(P) binding site [chemical binding]; other site 944546002118 active site 944546002119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546002120 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 944546002121 active site 944546002122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944546002123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546002124 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 944546002125 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944546002126 NAD(P) binding site [chemical binding]; other site 944546002127 homodimer interface [polypeptide binding]; other site 944546002128 substrate binding site [chemical binding]; other site 944546002129 active site 944546002130 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 944546002131 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 944546002132 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 944546002133 active site 944546002134 homodimer interface [polypeptide binding]; other site 944546002135 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 944546002136 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 944546002137 NADP binding site [chemical binding]; other site 944546002138 active site 944546002139 putative substrate binding site [chemical binding]; other site 944546002140 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 944546002141 putative glycosyl transferase; Provisional; Region: PRK10307 944546002142 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 944546002143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546002144 NAD(P) binding site [chemical binding]; other site 944546002145 active site 944546002146 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 944546002147 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 944546002148 Mg++ binding site [ion binding]; other site 944546002149 putative catalytic motif [active] 944546002150 putative substrate binding site [chemical binding]; other site 944546002151 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 944546002152 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 944546002153 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944546002154 NAD(P) binding site [chemical binding]; other site 944546002155 homodimer interface [polypeptide binding]; other site 944546002156 substrate binding site [chemical binding]; other site 944546002157 active site 944546002158 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 944546002159 DNA ligase; Provisional; Region: PRK09125 944546002160 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 944546002161 DNA binding site [nucleotide binding] 944546002162 active site 944546002163 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 944546002164 DNA binding site [nucleotide binding] 944546002165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546002166 active site 944546002167 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 944546002168 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 944546002169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546002170 catalytic residue [active] 944546002171 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944546002172 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 944546002173 multifunctional aminopeptidase A; Provisional; Region: PRK00913 944546002174 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 944546002175 interface (dimer of trimers) [polypeptide binding]; other site 944546002176 Substrate-binding/catalytic site; other site 944546002177 Zn-binding sites [ion binding]; other site 944546002178 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944546002179 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 944546002180 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944546002181 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 944546002182 Outer membrane efflux protein; Region: OEP; pfam02321 944546002183 Outer membrane efflux protein; Region: OEP; pfam02321 944546002184 HlyD family secretion protein; Region: HlyD_2; pfam12700 944546002185 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546002186 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546002187 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546002188 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944546002189 Walker A/P-loop; other site 944546002190 ATP binding site [chemical binding]; other site 944546002191 Q-loop/lid; other site 944546002192 ABC transporter signature motif; other site 944546002193 Walker B; other site 944546002194 D-loop; other site 944546002195 H-loop/switch region; other site 944546002196 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 944546002197 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 944546002198 FtsX-like permease family; Region: FtsX; pfam02687 944546002199 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546002200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546002201 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 944546002202 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944546002203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546002204 active site 944546002205 motif I; other site 944546002206 motif II; other site 944546002207 YtxH-like protein; Region: YtxH; pfam12732 944546002208 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 944546002209 diiron binding motif [ion binding]; other site 944546002210 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944546002211 metal binding site 2 [ion binding]; metal-binding site 944546002212 putative DNA binding helix; other site 944546002213 metal binding site 1 [ion binding]; metal-binding site 944546002214 dimer interface [polypeptide binding]; other site 944546002215 structural Zn2+ binding site [ion binding]; other site 944546002216 fumarate hydratase; Reviewed; Region: fumC; PRK00485 944546002217 Class II fumarases; Region: Fumarase_classII; cd01362 944546002218 active site 944546002219 tetramer interface [polypeptide binding]; other site 944546002220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 944546002221 Histidine kinase; Region: HisKA_2; pfam07568 944546002222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546002223 ATP binding site [chemical binding]; other site 944546002224 Mg2+ binding site [ion binding]; other site 944546002225 G-X-G motif; other site 944546002226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546002227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546002228 active site 944546002229 phosphorylation site [posttranslational modification] 944546002230 intermolecular recognition site; other site 944546002231 dimerization interface [polypeptide binding]; other site 944546002232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546002233 DNA binding site [nucleotide binding] 944546002234 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 944546002235 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546002236 N-terminal plug; other site 944546002237 ligand-binding site [chemical binding]; other site 944546002238 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 944546002239 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 944546002240 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 944546002241 active site 944546002242 substrate binding site [chemical binding]; other site 944546002243 FMN binding site [chemical binding]; other site 944546002244 putative catalytic residues [active] 944546002245 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 944546002246 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546002247 N-terminal plug; other site 944546002248 ligand-binding site [chemical binding]; other site 944546002249 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 944546002250 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 944546002251 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 944546002252 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 944546002253 Protein of unknown function (DUF466); Region: DUF466; pfam04328 944546002254 carbon starvation protein A; Provisional; Region: PRK15015 944546002255 Carbon starvation protein CstA; Region: CstA; pfam02554 944546002256 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 944546002257 GTP-binding protein YchF; Reviewed; Region: PRK09601 944546002258 YchF GTPase; Region: YchF; cd01900 944546002259 G1 box; other site 944546002260 GTP/Mg2+ binding site [chemical binding]; other site 944546002261 Switch I region; other site 944546002262 G2 box; other site 944546002263 Switch II region; other site 944546002264 G3 box; other site 944546002265 G4 box; other site 944546002266 G5 box; other site 944546002267 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 944546002268 HDOD domain; Region: HDOD; pfam08668 944546002269 putative recombination protein RecO; Provisional; Region: PRK13908 944546002270 phosphoenolpyruvate synthase; Validated; Region: PRK06241 944546002271 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 944546002272 NosL; Region: NosL; cl01769 944546002273 thiamine monophosphate kinase; Provisional; Region: PRK05731 944546002274 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 944546002275 ATP binding site [chemical binding]; other site 944546002276 dimerization interface [polypeptide binding]; other site 944546002277 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 944546002278 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 944546002279 Permutation of conserved domain; other site 944546002280 active site 944546002281 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 944546002282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002283 dimer interface [polypeptide binding]; other site 944546002284 putative CheW interface [polypeptide binding]; other site 944546002285 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 944546002286 RuvA N terminal domain; Region: RuvA_N; pfam01330 944546002287 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 944546002288 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 944546002289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944546002290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944546002291 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 944546002292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944546002293 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 944546002294 nucleotide binding site/active site [active] 944546002295 HIT family signature motif; other site 944546002296 catalytic residue [active] 944546002297 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 944546002298 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 944546002299 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 944546002300 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 944546002301 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 944546002302 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 944546002303 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 944546002304 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 944546002305 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 944546002306 putative translocon binding site; other site 944546002307 protein-rRNA interface [nucleotide binding]; other site 944546002308 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 944546002309 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 944546002310 G-X-X-G motif; other site 944546002311 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 944546002312 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 944546002313 23S rRNA interface [nucleotide binding]; other site 944546002314 5S rRNA interface [nucleotide binding]; other site 944546002315 putative antibiotic binding site [chemical binding]; other site 944546002316 L25 interface [polypeptide binding]; other site 944546002317 L27 interface [polypeptide binding]; other site 944546002318 50S ribosomal protein L29; Reviewed; Region: PRK00306 944546002319 trigger factor interaction site; other site 944546002320 23S rRNA interface [nucleotide binding]; other site 944546002321 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 944546002322 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 944546002323 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 944546002324 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 944546002325 RNA binding site [nucleotide binding]; other site 944546002326 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 944546002327 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 944546002328 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 944546002329 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 944546002330 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 944546002331 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 944546002332 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 944546002333 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 944546002334 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 944546002335 5S rRNA interface [nucleotide binding]; other site 944546002336 L27 interface [polypeptide binding]; other site 944546002337 23S rRNA interface [nucleotide binding]; other site 944546002338 L5 interface [polypeptide binding]; other site 944546002339 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 944546002340 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 944546002341 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 944546002342 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 944546002343 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 944546002344 SecY translocase; Region: SecY; pfam00344 944546002345 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 944546002346 active site 944546002347 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 944546002348 rRNA binding site [nucleotide binding]; other site 944546002349 predicted 30S ribosome binding site; other site 944546002350 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 944546002351 Fe-S cluster binding site [ion binding]; other site 944546002352 active site 944546002353 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 944546002354 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 944546002355 dimer interface [polypeptide binding]; other site 944546002356 anticodon binding site; other site 944546002357 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 944546002358 homodimer interface [polypeptide binding]; other site 944546002359 motif 1; other site 944546002360 active site 944546002361 motif 2; other site 944546002362 GAD domain; Region: GAD; pfam02938 944546002363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 944546002364 active site 944546002365 motif 3; other site 944546002366 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 944546002367 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 944546002368 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 944546002369 adenylate kinase; Reviewed; Region: adk; PRK00279 944546002370 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 944546002371 AMP-binding site [chemical binding]; other site 944546002372 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 944546002373 adenylate kinase; Reviewed; Region: adk; PRK00279 944546002374 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 944546002375 AMP-binding site [chemical binding]; other site 944546002376 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 944546002377 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 944546002378 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 944546002379 MPT binding site; other site 944546002380 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 944546002381 Chloramphenicol acetyltransferase; Region: CAT; smart01059 944546002382 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 944546002383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546002384 Coenzyme A binding pocket [chemical binding]; other site 944546002385 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 944546002386 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 944546002387 putative NAD(P) binding site [chemical binding]; other site 944546002388 putative substrate binding site [chemical binding]; other site 944546002389 catalytic Zn binding site [ion binding]; other site 944546002390 structural Zn binding site [ion binding]; other site 944546002391 dimer interface [polypeptide binding]; other site 944546002392 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 944546002393 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 944546002394 dimer interface [polypeptide binding]; other site 944546002395 active site 944546002396 metal binding site [ion binding]; metal-binding site 944546002397 Cache domain; Region: Cache_1; pfam02743 944546002398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546002399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002400 dimer interface [polypeptide binding]; other site 944546002401 putative CheW interface [polypeptide binding]; other site 944546002402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 944546002403 alanine racemase; Reviewed; Region: alr; PRK00053 944546002404 active site 944546002405 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944546002406 dimer interface [polypeptide binding]; other site 944546002407 substrate binding site [chemical binding]; other site 944546002408 catalytic residues [active] 944546002409 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 944546002410 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 944546002411 GIY-YIG motif/motif A; other site 944546002412 active site 944546002413 catalytic site [active] 944546002414 putative DNA binding site [nucleotide binding]; other site 944546002415 metal binding site [ion binding]; metal-binding site 944546002416 UvrB/uvrC motif; Region: UVR; pfam02151 944546002417 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 944546002418 Cache domain; Region: Cache_1; pfam02743 944546002419 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 944546002420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002421 dimer interface [polypeptide binding]; other site 944546002422 putative CheW interface [polypeptide binding]; other site 944546002423 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944546002424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002425 dimer interface [polypeptide binding]; other site 944546002426 putative CheW interface [polypeptide binding]; other site 944546002427 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944546002428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002429 dimer interface [polypeptide binding]; other site 944546002430 putative CheW interface [polypeptide binding]; other site 944546002431 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944546002432 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002433 dimer interface [polypeptide binding]; other site 944546002434 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546002435 putative CheW interface [polypeptide binding]; other site 944546002436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944546002437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944546002438 Bacterial transcriptional repressor; Region: TetR; pfam13972 944546002439 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 944546002440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944546002441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546002442 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546002443 Outer membrane efflux protein; Region: OEP; pfam02321 944546002444 Outer membrane efflux protein; Region: OEP; pfam02321 944546002445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 944546002446 MarR family; Region: MarR_2; cl17246 944546002447 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 944546002448 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546002449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546002450 metal binding site [ion binding]; metal-binding site 944546002451 active site 944546002452 I-site; other site 944546002453 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 944546002454 putative catalytic site [active] 944546002455 putative metal binding site [ion binding]; other site 944546002456 putative phosphate binding site [ion binding]; other site 944546002457 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944546002458 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 944546002459 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 944546002460 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 944546002461 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 944546002462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546002463 FeS/SAM binding site; other site 944546002464 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 944546002465 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 944546002466 ABC1 family; Region: ABC1; cl17513 944546002467 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 944546002468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546002469 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 944546002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546002471 active site 944546002472 phosphorylation site [posttranslational modification] 944546002473 intermolecular recognition site; other site 944546002474 dimerization interface [polypeptide binding]; other site 944546002475 LytTr DNA-binding domain; Region: LytTR; smart00850 944546002476 Histidine kinase; Region: His_kinase; pfam06580 944546002477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944546002478 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 944546002479 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 944546002480 DNA photolyase; Region: DNA_photolyase; pfam00875 944546002481 Protein of unknown function (DUF523); Region: DUF523; pfam04463 944546002482 Uncharacterized conserved protein [Function unknown]; Region: COG3272 944546002483 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 944546002484 Predicted permeases [General function prediction only]; Region: COG0679 944546002485 Domain of unknown function (DUF386); Region: DUF386; cl01047 944546002486 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 944546002487 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 944546002488 active site 944546002489 dimer interface [polypeptide binding]; other site 944546002490 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 944546002491 dimer interface [polypeptide binding]; other site 944546002492 active site 944546002493 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 944546002494 active site 944546002495 tetramer interface; other site 944546002496 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 944546002497 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 944546002498 active site 944546002499 substrate binding site [chemical binding]; other site 944546002500 metal binding site [ion binding]; metal-binding site 944546002501 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546002502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002503 dimer interface [polypeptide binding]; other site 944546002504 putative CheW interface [polypeptide binding]; other site 944546002505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546002506 PAS domain; Region: PAS_9; pfam13426 944546002507 putative active site [active] 944546002508 heme pocket [chemical binding]; other site 944546002509 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 944546002510 active site 1 [active] 944546002511 dimer interface [polypeptide binding]; other site 944546002512 hexamer interface [polypeptide binding]; other site 944546002513 active site 2 [active] 944546002514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944546002515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944546002516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944546002517 dimerization interface [polypeptide binding]; other site 944546002518 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 944546002519 active site 944546002520 ribulose/triose binding site [chemical binding]; other site 944546002521 phosphate binding site [ion binding]; other site 944546002522 substrate (anthranilate) binding pocket [chemical binding]; other site 944546002523 product (indole) binding pocket [chemical binding]; other site 944546002524 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 944546002525 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 944546002526 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 944546002527 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 944546002528 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944546002529 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 944546002530 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 944546002531 dimer interface [polypeptide binding]; other site 944546002532 PYR/PP interface [polypeptide binding]; other site 944546002533 TPP binding site [chemical binding]; other site 944546002534 substrate binding site [chemical binding]; other site 944546002535 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944546002536 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 944546002537 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 944546002538 TPP-binding site [chemical binding]; other site 944546002539 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 944546002540 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 944546002541 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944546002542 active site 944546002543 catalytic site [active] 944546002544 substrate binding site [chemical binding]; other site 944546002545 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 944546002546 active site 944546002547 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 944546002548 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 944546002549 substrate binding site [chemical binding]; other site 944546002550 hexamer interface [polypeptide binding]; other site 944546002551 metal binding site [ion binding]; metal-binding site 944546002552 Phospholipase A1; Region: PLA1; pfam02253 944546002553 dimerization interface [polypeptide binding]; other site 944546002554 substrate binding site [chemical binding]; other site 944546002555 active site 944546002556 calcium binding site [ion binding]; other site 944546002557 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 944546002558 dimer interface [polypeptide binding]; other site 944546002559 ADP-ribose binding site [chemical binding]; other site 944546002560 active site 944546002561 nudix motif; other site 944546002562 metal binding site [ion binding]; metal-binding site 944546002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 944546002564 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 944546002565 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 944546002566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546002567 NAD(P) binding site [chemical binding]; other site 944546002568 active site 944546002569 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 944546002570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546002571 active site 944546002572 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 944546002573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944546002574 catalytic residue [active] 944546002575 Domain of unknown function (DUF932); Region: DUF932; cl12129 944546002576 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 944546002577 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 944546002578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944546002579 non-specific DNA binding site [nucleotide binding]; other site 944546002580 salt bridge; other site 944546002581 sequence-specific DNA binding site [nucleotide binding]; other site 944546002582 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 944546002583 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 944546002584 HsdM N-terminal domain; Region: HsdM_N; pfam12161 944546002585 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 944546002586 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 944546002587 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 944546002588 Fic/DOC family; Region: Fic; cl00960 944546002589 Uncharacterized conserved protein [Function unknown]; Region: COG1479 944546002590 Protein of unknown function DUF262; Region: DUF262; pfam03235 944546002591 Uncharacterized conserved protein [Function unknown]; Region: COG1479 944546002592 Protein of unknown function DUF262; Region: DUF262; pfam03235 944546002593 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 944546002594 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 944546002595 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 944546002596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546002597 ATP binding site [chemical binding]; other site 944546002598 putative Mg++ binding site [ion binding]; other site 944546002599 Protein of unknown function DUF45; Region: DUF45; pfam01863 944546002600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 944546002601 non-specific DNA binding site [nucleotide binding]; other site 944546002602 salt bridge; other site 944546002603 sequence-specific DNA binding site [nucleotide binding]; other site 944546002604 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 944546002605 G1 box; other site 944546002606 GTP/Mg2+ binding site [chemical binding]; other site 944546002607 G2 box; other site 944546002608 G3 box; other site 944546002609 Switch II region; other site 944546002610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 944546002611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944546002612 non-specific DNA binding site [nucleotide binding]; other site 944546002613 salt bridge; other site 944546002614 sequence-specific DNA binding site [nucleotide binding]; other site 944546002615 HipA N-terminal domain; Region: Couple_hipA; pfam13657 944546002616 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 944546002617 HipA-like N-terminal domain; Region: HipA_N; pfam07805 944546002618 HipA-like C-terminal domain; Region: HipA_C; pfam07804 944546002619 PAS fold; Region: PAS; pfam00989 944546002620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546002621 putative active site [active] 944546002622 heme pocket [chemical binding]; other site 944546002623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002624 dimer interface [polypeptide binding]; other site 944546002625 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546002626 putative CheW interface [polypeptide binding]; other site 944546002627 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546002628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546002629 dimer interface [polypeptide binding]; other site 944546002630 putative CheW interface [polypeptide binding]; other site 944546002631 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546002632 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944546002633 active site 944546002634 Int/Topo IB signature motif; other site 944546002635 catalytic residues [active] 944546002636 DNA binding site [nucleotide binding] 944546002637 RIP metalloprotease RseP; Region: TIGR00054 944546002638 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 944546002639 active site 944546002640 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 944546002641 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 944546002642 putative substrate binding region [chemical binding]; other site 944546002643 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 944546002644 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 944546002645 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 944546002646 putative NAD(P) binding site [chemical binding]; other site 944546002647 active site 944546002648 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 944546002649 dihydrodipicolinate synthase; Region: dapA; TIGR00674 944546002650 dimer interface [polypeptide binding]; other site 944546002651 active site 944546002652 catalytic residue [active] 944546002653 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 944546002654 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 944546002655 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 944546002656 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 944546002657 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 944546002658 quinone interaction residues [chemical binding]; other site 944546002659 active site 944546002660 catalytic residues [active] 944546002661 FMN binding site [chemical binding]; other site 944546002662 substrate binding site [chemical binding]; other site 944546002663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 944546002664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944546002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546002666 Walker A/P-loop; other site 944546002667 ATP binding site [chemical binding]; other site 944546002668 Q-loop/lid; other site 944546002669 ABC transporter signature motif; other site 944546002670 Walker B; other site 944546002671 D-loop; other site 944546002672 H-loop/switch region; other site 944546002673 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 944546002674 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 944546002675 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944546002676 metal binding site 2 [ion binding]; metal-binding site 944546002677 putative DNA binding helix; other site 944546002678 metal binding site 1 [ion binding]; metal-binding site 944546002679 dimer interface [polypeptide binding]; other site 944546002680 structural Zn2+ binding site [ion binding]; other site 944546002681 metal-binding heat shock protein; Provisional; Region: PRK00016 944546002682 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 944546002683 active site 2 [active] 944546002684 active site 1 [active] 944546002685 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 944546002686 catalytic triad [active] 944546002687 active site nucleophile [active] 944546002688 DNA repair protein RadA; Provisional; Region: PRK11823 944546002689 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 944546002690 Walker A motif/ATP binding site; other site 944546002691 ATP binding site [chemical binding]; other site 944546002692 Walker B motif; other site 944546002693 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 944546002694 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 944546002695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944546002696 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 944546002697 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 944546002698 PAS domain S-box; Region: sensory_box; TIGR00229 944546002699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546002700 putative active site [active] 944546002701 heme pocket [chemical binding]; other site 944546002702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546002703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546002704 metal binding site [ion binding]; metal-binding site 944546002705 active site 944546002706 I-site; other site 944546002707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546002708 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 944546002709 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 944546002710 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 944546002711 P loop; other site 944546002712 GTP binding site [chemical binding]; other site 944546002713 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 944546002714 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944546002715 catalytic residues [active] 944546002716 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 944546002717 phosphodiesterase; Provisional; Region: PRK12704 944546002718 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 944546002719 TFIIA subunit interface [polypeptide binding]; other site 944546002720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546002721 Zn2+ binding site [ion binding]; other site 944546002722 Mg2+ binding site [ion binding]; other site 944546002723 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 944546002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 944546002725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 944546002726 short chain dehydrogenase; Provisional; Region: PRK05993 944546002727 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 944546002728 NADP binding site [chemical binding]; other site 944546002729 active site 944546002730 steroid binding site; other site 944546002731 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 944546002732 Cytochrome c [Energy production and conversion]; Region: COG3258 944546002733 Cytochrome c; Region: Cytochrom_C; pfam00034 944546002734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546002735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546002736 active site 944546002737 phosphorylation site [posttranslational modification] 944546002738 intermolecular recognition site; other site 944546002739 dimerization interface [polypeptide binding]; other site 944546002740 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546002741 DNA binding site [nucleotide binding] 944546002742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546002743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546002744 dimer interface [polypeptide binding]; other site 944546002745 phosphorylation site [posttranslational modification] 944546002746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546002747 ATP binding site [chemical binding]; other site 944546002748 Mg2+ binding site [ion binding]; other site 944546002749 G-X-G motif; other site 944546002750 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 944546002751 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 944546002752 dimerization interface [polypeptide binding]; other site 944546002753 active site 944546002754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546002755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546002756 metal binding site [ion binding]; metal-binding site 944546002757 active site 944546002758 I-site; other site 944546002759 Yqey-like protein; Region: YqeY; pfam09424 944546002760 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 944546002761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546002762 Walker A/P-loop; other site 944546002763 ATP binding site [chemical binding]; other site 944546002764 Q-loop/lid; other site 944546002765 ABC transporter signature motif; other site 944546002766 Walker B; other site 944546002767 D-loop; other site 944546002768 H-loop/switch region; other site 944546002769 ABC transporter; Region: ABC_tran_2; pfam12848 944546002770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944546002771 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 944546002772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 944546002773 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 944546002774 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 944546002775 active site 944546002776 Zn binding site [ion binding]; other site 944546002777 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 944546002778 homotrimer interaction site [polypeptide binding]; other site 944546002779 putative active site [active] 944546002780 Uncharacterized conserved protein [Function unknown]; Region: COG0397 944546002781 hypothetical protein; Validated; Region: PRK00029 944546002782 GMP synthase; Reviewed; Region: guaA; PRK00074 944546002783 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 944546002784 AMP/PPi binding site [chemical binding]; other site 944546002785 candidate oxyanion hole; other site 944546002786 catalytic triad [active] 944546002787 potential glutamine specificity residues [chemical binding]; other site 944546002788 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 944546002789 ATP Binding subdomain [chemical binding]; other site 944546002790 Ligand Binding sites [chemical binding]; other site 944546002791 Dimerization subdomain; other site 944546002792 L-aspartate oxidase; Provisional; Region: PRK06175 944546002793 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 944546002794 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 944546002795 Protein of unknown function (DUF721); Region: DUF721; cl02324 944546002796 Protein of unknown function DUF45; Region: DUF45; pfam01863 944546002797 aspartate aminotransferase; Provisional; Region: PRK05764 944546002798 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546002799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546002800 homodimer interface [polypeptide binding]; other site 944546002801 catalytic residue [active] 944546002802 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 944546002803 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 944546002804 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 944546002805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 944546002806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 944546002807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546002808 Zn2+ binding site [ion binding]; other site 944546002809 Mg2+ binding site [ion binding]; other site 944546002810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546002811 CHASE2 domain; Region: CHASE2; pfam05226 944546002812 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 944546002813 cyclase homology domain; Region: CHD; cd07302 944546002814 nucleotidyl binding site; other site 944546002815 metal binding site [ion binding]; metal-binding site 944546002816 dimer interface [polypeptide binding]; other site 944546002817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 944546002818 Tetratricopeptide repeat; Region: TPR_16; pfam13432 944546002819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546002820 TPR motif; other site 944546002821 FecR protein; Region: FecR; pfam04773 944546002822 Acyltransferase family; Region: Acyl_transf_3; pfam01757 944546002823 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 944546002824 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 944546002825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546002826 S-adenosylmethionine binding site [chemical binding]; other site 944546002827 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 944546002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546002829 putative substrate translocation pore; other site 944546002830 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 944546002831 cobalt transport protein CbiM; Validated; Region: PRK06265 944546002832 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 944546002833 SH3 domain-containing protein; Provisional; Region: PRK10884 944546002834 Cobalt transport protein; Region: CbiQ; cl00463 944546002835 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546002836 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 944546002837 Walker A/P-loop; other site 944546002838 ATP binding site [chemical binding]; other site 944546002839 Q-loop/lid; other site 944546002840 ABC transporter signature motif; other site 944546002841 Walker B; other site 944546002842 D-loop; other site 944546002843 H-loop/switch region; other site 944546002844 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 944546002845 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 944546002846 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 944546002847 haemagglutination activity domain; Region: Haemagg_act; pfam05860 944546002848 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 944546002849 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 944546002850 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 944546002851 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 944546002852 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 944546002853 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 944546002854 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 944546002855 Catalytic domain of Protein Kinases; Region: PKc; cd00180 944546002856 active site 944546002857 ATP binding site [chemical binding]; other site 944546002858 substrate binding site [chemical binding]; other site 944546002859 activation loop (A-loop); other site 944546002860 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 944546002861 Domain of unknown function DUF20; Region: UPF0118; pfam01594 944546002862 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 944546002863 Domain of unknown function DUF87; Region: DUF87; pfam01935 944546002864 Zonular occludens toxin (Zot); Region: Zot; cl17485 944546002865 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 944546002866 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 944546002867 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 944546002868 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 944546002869 PAS fold; Region: PAS; pfam00989 944546002870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546002871 putative active site [active] 944546002872 heme pocket [chemical binding]; other site 944546002873 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944546002874 serine O-acetyltransferase; Region: cysE; TIGR01172 944546002875 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 944546002876 trimer interface [polypeptide binding]; other site 944546002877 active site 944546002878 substrate binding site [chemical binding]; other site 944546002879 CoA binding site [chemical binding]; other site 944546002880 arginine decarboxylase; Provisional; Region: PRK05354 944546002881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 944546002882 dimer interface [polypeptide binding]; other site 944546002883 active site 944546002884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944546002885 catalytic residues [active] 944546002886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 944546002887 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 944546002888 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 944546002889 dimer interface [polypeptide binding]; other site 944546002890 motif 1; other site 944546002891 active site 944546002892 motif 2; other site 944546002893 motif 3; other site 944546002894 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 944546002895 anticodon binding site; other site 944546002896 thymidylate kinase; Validated; Region: tmk; PRK00698 944546002897 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 944546002898 TMP-binding site; other site 944546002899 ATP-binding site [chemical binding]; other site 944546002900 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 944546002901 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 944546002902 active site 944546002903 (T/H)XGH motif; other site 944546002904 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 944546002905 Flavoprotein; Region: Flavoprotein; pfam02441 944546002906 multiple promoter invertase; Provisional; Region: mpi; PRK13413 944546002907 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 944546002908 catalytic residues [active] 944546002909 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 944546002910 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 944546002911 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 944546002912 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 944546002913 active site 944546002914 HslU subunit interaction site [polypeptide binding]; other site 944546002915 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 944546002916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546002917 Walker A motif; other site 944546002918 ATP binding site [chemical binding]; other site 944546002919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546002920 Walker B motif; other site 944546002921 arginine finger; other site 944546002922 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944546002923 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 944546002924 active site 944546002925 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 944546002926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 944546002927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 944546002928 catalytic residue [active] 944546002929 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 944546002930 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 944546002931 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 944546002932 Sporulation related domain; Region: SPOR; pfam05036 944546002933 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 944546002934 putative active site pocket [active] 944546002935 4-fold oligomerization interface [polypeptide binding]; other site 944546002936 metal binding residues [ion binding]; metal-binding site 944546002937 3-fold/trimer interface [polypeptide binding]; other site 944546002938 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 944546002939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546002940 active site 944546002941 motif I; other site 944546002942 motif II; other site 944546002943 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 944546002944 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 944546002945 OstA-like protein; Region: OstA; pfam03968 944546002946 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 944546002947 G1 box; other site 944546002948 GTP/Mg2+ binding site [chemical binding]; other site 944546002949 Switch I region; other site 944546002950 G2 box; other site 944546002951 G3 box; other site 944546002952 Switch II region; other site 944546002953 G4 box; other site 944546002954 G5 box; other site 944546002955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546002956 Coenzyme A binding pocket [chemical binding]; other site 944546002957 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 944546002958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546002959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546002960 DNA binding residues [nucleotide binding] 944546002961 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546002962 FecR protein; Region: FecR; pfam04773 944546002963 Secretin and TonB N terminus short domain; Region: STN; smart00965 944546002964 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546002965 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546002966 N-terminal plug; other site 944546002967 ligand-binding site [chemical binding]; other site 944546002968 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 944546002969 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 944546002970 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 944546002971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 944546002972 DNA-binding site [nucleotide binding]; DNA binding site 944546002973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546002974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546002975 homodimer interface [polypeptide binding]; other site 944546002976 catalytic residue [active] 944546002977 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 944546002978 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944546002979 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944546002980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546002981 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546002982 Outer membrane efflux protein; Region: OEP; pfam02321 944546002983 Outer membrane efflux protein; Region: OEP; pfam02321 944546002984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546002985 PAS domain; Region: PAS_9; pfam13426 944546002986 putative active site [active] 944546002987 heme pocket [chemical binding]; other site 944546002988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546002989 Zn2+ binding site [ion binding]; other site 944546002990 Mg2+ binding site [ion binding]; other site 944546002991 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 944546002992 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 944546002993 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 944546002994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 944546002995 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944546002996 Peptidase family M23; Region: Peptidase_M23; pfam01551 944546002997 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546002998 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944546002999 Walker A/P-loop; other site 944546003000 ATP binding site [chemical binding]; other site 944546003001 Q-loop/lid; other site 944546003002 ABC transporter signature motif; other site 944546003003 Walker B; other site 944546003004 D-loop; other site 944546003005 H-loop/switch region; other site 944546003006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003007 S-adenosylmethionine binding site [chemical binding]; other site 944546003008 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 944546003009 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 944546003010 Interdomain contacts; other site 944546003011 Cytokine receptor motif; other site 944546003012 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 944546003013 Interdomain contacts; other site 944546003014 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944546003015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546003016 RNA binding surface [nucleotide binding]; other site 944546003017 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944546003018 active site 944546003019 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 944546003020 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 944546003021 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 944546003022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944546003023 inhibitor-cofactor binding pocket; inhibition site 944546003024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546003025 catalytic residue [active] 944546003026 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 944546003027 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 944546003028 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 944546003029 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 944546003030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546003031 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 944546003032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546003033 DNA binding residues [nucleotide binding] 944546003034 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 944546003035 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 944546003036 substrate binding site [chemical binding]; other site 944546003037 tartrate dehydrogenase; Region: TTC; TIGR02089 944546003038 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 944546003039 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 944546003040 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 944546003041 HIT family signature motif; other site 944546003042 catalytic residue [active] 944546003043 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 944546003044 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 944546003045 30S ribosomal protein S13; Region: bact_S13; TIGR03631 944546003046 30S ribosomal protein S11; Validated; Region: PRK05309 944546003047 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 944546003048 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 944546003049 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546003050 RNA binding surface [nucleotide binding]; other site 944546003051 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 944546003052 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 944546003053 alphaNTD homodimer interface [polypeptide binding]; other site 944546003054 alphaNTD - beta interaction site [polypeptide binding]; other site 944546003055 alphaNTD - beta' interaction site [polypeptide binding]; other site 944546003056 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 944546003057 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 944546003058 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 944546003059 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 944546003060 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 944546003061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 944546003062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 944546003063 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 944546003064 active site 944546003065 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 944546003066 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944546003067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546003068 substrate binding pocket [chemical binding]; other site 944546003069 membrane-bound complex binding site; other site 944546003070 hinge residues; other site 944546003071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003074 active site 944546003075 phosphorylation site [posttranslational modification] 944546003076 intermolecular recognition site; other site 944546003077 dimerization interface [polypeptide binding]; other site 944546003078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546003079 DNA binding site [nucleotide binding] 944546003080 Outer membrane efflux protein; Region: OEP; pfam02321 944546003081 Outer membrane efflux protein; Region: OEP; pfam02321 944546003082 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546003083 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546003084 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 944546003085 VCBS repeat; Region: VCBS_repeat; TIGR01965 944546003086 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 944546003087 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 944546003088 Ca2+ binding site [ion binding]; other site 944546003089 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 944546003090 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546003091 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546003092 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 944546003093 Peptidase family M50; Region: Peptidase_M50; pfam02163 944546003094 active site 944546003095 putative substrate binding region [chemical binding]; other site 944546003096 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 944546003097 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546003098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944546003099 HSP70 interaction site [polypeptide binding]; other site 944546003100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944546003101 HSP70 interaction site [polypeptide binding]; other site 944546003102 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 944546003103 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 944546003104 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 944546003105 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944546003106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003108 ATP binding site [chemical binding]; other site 944546003109 Mg2+ binding site [ion binding]; other site 944546003110 G-X-G motif; other site 944546003111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003113 active site 944546003114 phosphorylation site [posttranslational modification] 944546003115 intermolecular recognition site; other site 944546003116 dimerization interface [polypeptide binding]; other site 944546003117 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546003118 DNA binding site [nucleotide binding] 944546003119 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 944546003120 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 944546003121 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 944546003122 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 944546003123 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 944546003124 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 944546003125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003126 Walker A/P-loop; other site 944546003127 ATP binding site [chemical binding]; other site 944546003128 Q-loop/lid; other site 944546003129 ABC transporter signature motif; other site 944546003130 Walker B; other site 944546003131 D-loop; other site 944546003132 H-loop/switch region; other site 944546003133 RNA polymerase sigma factor; Reviewed; Region: PRK12527 944546003134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546003135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546003136 DNA binding residues [nucleotide binding] 944546003137 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546003138 FecR protein; Region: FecR; pfam04773 944546003139 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 944546003140 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 944546003141 tetramer interface [polypeptide binding]; other site 944546003142 catalytic Zn binding site [ion binding]; other site 944546003143 NADP binding site [chemical binding]; other site 944546003144 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944546003145 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944546003146 ligand binding site [chemical binding]; other site 944546003147 flexible hinge region; other site 944546003148 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944546003149 EamA-like transporter family; Region: EamA; pfam00892 944546003150 Predicted transcriptional regulators [Transcription]; Region: COG1733 944546003151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944546003152 dimerization interface [polypeptide binding]; other site 944546003153 putative DNA binding site [nucleotide binding]; other site 944546003154 putative Zn2+ binding site [ion binding]; other site 944546003155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944546003156 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 944546003157 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 944546003158 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 944546003159 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 944546003160 EamA-like transporter family; Region: EamA; pfam00892 944546003161 EamA-like transporter family; Region: EamA; pfam00892 944546003162 Helix-turn-helix domain; Region: HTH_18; pfam12833 944546003163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546003164 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 944546003165 substrate binding site [chemical binding]; other site 944546003166 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 944546003167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944546003168 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 944546003169 putative dimerization interface [polypeptide binding]; other site 944546003170 Predicted membrane protein [Function unknown]; Region: COG2855 944546003171 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 944546003172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546003173 substrate binding pocket [chemical binding]; other site 944546003174 membrane-bound complex binding site; other site 944546003175 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 944546003176 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 944546003177 active site 944546003178 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 944546003179 dinuclear metal binding motif [ion binding]; other site 944546003180 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 944546003181 dimerization domain [polypeptide binding]; other site 944546003182 dimer interface [polypeptide binding]; other site 944546003183 catalytic residues [active] 944546003184 Membrane transport protein; Region: Mem_trans; cl09117 944546003185 Predicted transcriptional regulators [Transcription]; Region: COG1733 944546003186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944546003187 dimerization interface [polypeptide binding]; other site 944546003188 putative DNA binding site [nucleotide binding]; other site 944546003189 putative Zn2+ binding site [ion binding]; other site 944546003190 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 944546003191 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 944546003192 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 944546003193 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 944546003194 active site 944546003195 FMN binding site [chemical binding]; other site 944546003196 substrate binding site [chemical binding]; other site 944546003197 homotetramer interface [polypeptide binding]; other site 944546003198 catalytic residue [active] 944546003199 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 944546003200 EamA-like transporter family; Region: EamA; pfam00892 944546003201 EamA-like transporter family; Region: EamA; pfam00892 944546003202 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 944546003203 dimer interface [polypeptide binding]; other site 944546003204 FMN binding site [chemical binding]; other site 944546003205 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 944546003206 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 944546003207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003208 Walker A/P-loop; other site 944546003209 ATP binding site [chemical binding]; other site 944546003210 Q-loop/lid; other site 944546003211 ABC transporter signature motif; other site 944546003212 Walker B; other site 944546003213 D-loop; other site 944546003214 H-loop/switch region; other site 944546003215 ABC transporter; Region: ABC_tran_2; pfam12848 944546003216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944546003217 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 944546003218 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546003219 dimer interface [polypeptide binding]; other site 944546003220 putative CheW interface [polypeptide binding]; other site 944546003221 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 944546003222 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 944546003223 nucleotide binding pocket [chemical binding]; other site 944546003224 K-X-D-G motif; other site 944546003225 catalytic site [active] 944546003226 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 944546003227 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 944546003228 Dimer interface [polypeptide binding]; other site 944546003229 BRCT sequence motif; other site 944546003230 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 944546003231 hypothetical protein; Provisional; Region: PRK04081 944546003232 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 944546003233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 944546003234 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 944546003235 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 944546003236 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 944546003237 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 944546003238 shikimate binding site; other site 944546003239 NAD(P) binding site [chemical binding]; other site 944546003240 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944546003241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003242 S-adenosylmethionine binding site [chemical binding]; other site 944546003243 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 944546003244 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 944546003245 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 944546003246 Malic enzyme, N-terminal domain; Region: malic; pfam00390 944546003247 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 944546003248 putative NAD(P) binding site [chemical binding]; other site 944546003249 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 944546003250 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 944546003251 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 944546003252 putative active site [active] 944546003253 putative substrate binding site [chemical binding]; other site 944546003254 putative cosubstrate binding site; other site 944546003255 catalytic site [active] 944546003256 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 944546003257 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 944546003258 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944546003259 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 944546003260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003262 active site 944546003263 phosphorylation site [posttranslational modification] 944546003264 intermolecular recognition site; other site 944546003265 dimerization interface [polypeptide binding]; other site 944546003266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546003267 DNA binding site [nucleotide binding] 944546003268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546003270 phosphorylation site [posttranslational modification] 944546003271 dimer interface [polypeptide binding]; other site 944546003272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003273 ATP binding site [chemical binding]; other site 944546003274 Mg2+ binding site [ion binding]; other site 944546003275 G-X-G motif; other site 944546003276 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 944546003277 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 944546003278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546003279 TPR motif; other site 944546003280 TPR repeat; Region: TPR_11; pfam13414 944546003281 binding surface 944546003282 Protein of unknown function, DUF393; Region: DUF393; cl01136 944546003283 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 944546003284 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 944546003285 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 944546003286 active site 944546003287 uracil binding [chemical binding]; other site 944546003288 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 944546003289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546003290 motif II; other site 944546003291 Family description; Region: DsbD_2; pfam13386 944546003292 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 944546003293 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546003294 N-terminal plug; other site 944546003295 ligand-binding site [chemical binding]; other site 944546003296 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 944546003297 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 944546003298 intersubunit interface [polypeptide binding]; other site 944546003299 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 944546003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003301 Walker A/P-loop; other site 944546003302 ATP binding site [chemical binding]; other site 944546003303 Q-loop/lid; other site 944546003304 ABC transporter signature motif; other site 944546003305 Walker B; other site 944546003306 D-loop; other site 944546003307 H-loop/switch region; other site 944546003308 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 944546003309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 944546003310 ABC-ATPase subunit interface; other site 944546003311 dimer interface [polypeptide binding]; other site 944546003312 putative PBP binding regions; other site 944546003313 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944546003314 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944546003315 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 944546003316 catalytic core [active] 944546003317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 944546003318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944546003319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003320 Walker A/P-loop; other site 944546003321 ATP binding site [chemical binding]; other site 944546003322 Q-loop/lid; other site 944546003323 ABC transporter signature motif; other site 944546003324 Walker B; other site 944546003325 D-loop; other site 944546003326 H-loop/switch region; other site 944546003327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003329 active site 944546003330 phosphorylation site [posttranslational modification] 944546003331 intermolecular recognition site; other site 944546003332 dimerization interface [polypeptide binding]; other site 944546003333 DNA binding site [nucleotide binding] 944546003334 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546003335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546003337 dimer interface [polypeptide binding]; other site 944546003338 phosphorylation site [posttranslational modification] 944546003339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003340 ATP binding site [chemical binding]; other site 944546003341 Mg2+ binding site [ion binding]; other site 944546003342 G-X-G motif; other site 944546003343 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 944546003344 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 944546003345 flagellin; Provisional; Region: PRK12802 944546003346 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 944546003347 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944546003348 active site 944546003349 catalytic site [active] 944546003350 substrate binding site [chemical binding]; other site 944546003351 diguanylate cyclase; Provisional; Region: PRK09894 944546003352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546003353 metal binding site [ion binding]; metal-binding site 944546003354 active site 944546003355 I-site; other site 944546003356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944546003357 non-specific DNA binding site [nucleotide binding]; other site 944546003358 salt bridge; other site 944546003359 sequence-specific DNA binding site [nucleotide binding]; other site 944546003360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 944546003361 putative Mg++ binding site [ion binding]; other site 944546003362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546003363 nucleotide binding region [chemical binding]; other site 944546003364 ATP-binding site [chemical binding]; other site 944546003365 PAS domain S-box; Region: sensory_box; TIGR00229 944546003366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944546003367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003369 ATP binding site [chemical binding]; other site 944546003370 Mg2+ binding site [ion binding]; other site 944546003371 G-X-G motif; other site 944546003372 Response regulator receiver domain; Region: Response_reg; pfam00072 944546003373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003374 active site 944546003375 phosphorylation site [posttranslational modification] 944546003376 intermolecular recognition site; other site 944546003377 dimerization interface [polypeptide binding]; other site 944546003378 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546003379 DNA binding site [nucleotide binding] 944546003380 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 944546003381 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 944546003382 ligand binding site [chemical binding]; other site 944546003383 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546003384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546003385 ligand binding site [chemical binding]; other site 944546003386 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 944546003387 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 944546003388 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 944546003389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003390 Walker A/P-loop; other site 944546003391 ATP binding site [chemical binding]; other site 944546003392 Q-loop/lid; other site 944546003393 ABC transporter signature motif; other site 944546003394 Walker B; other site 944546003395 D-loop; other site 944546003396 H-loop/switch region; other site 944546003397 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 944546003398 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944546003399 E3 interaction surface; other site 944546003400 lipoyl attachment site [posttranslational modification]; other site 944546003401 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546003402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 944546003403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 944546003404 DNA binding residues [nucleotide binding] 944546003405 dimerization interface [polypeptide binding]; other site 944546003406 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 944546003407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546003408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546003409 metal binding site [ion binding]; metal-binding site 944546003410 active site 944546003411 I-site; other site 944546003412 EAL domain; Region: EAL; pfam00563 944546003413 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 944546003414 active site 944546003415 dimer interface [polypeptide binding]; other site 944546003416 metal binding site [ion binding]; metal-binding site 944546003417 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 944546003418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944546003419 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 944546003420 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 944546003421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546003422 FeS/SAM binding site; other site 944546003423 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 944546003424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546003425 Walker B motif; other site 944546003426 arginine finger; other site 944546003427 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 944546003428 MPT binding site; other site 944546003429 trimer interface [polypeptide binding]; other site 944546003430 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 944546003431 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 944546003432 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944546003433 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944546003434 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 944546003435 catalytic core [active] 944546003436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 944546003437 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 944546003438 dimer interface [polypeptide binding]; other site 944546003439 ligand binding site [chemical binding]; other site 944546003440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 944546003441 non-specific DNA binding site [nucleotide binding]; other site 944546003442 salt bridge; other site 944546003443 sequence-specific DNA binding site [nucleotide binding]; other site 944546003444 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944546003445 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 944546003446 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 944546003447 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 944546003448 molybdopterin cofactor binding site [chemical binding]; other site 944546003449 substrate binding site [chemical binding]; other site 944546003450 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 944546003451 molybdopterin cofactor binding site; other site 944546003452 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 944546003453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944546003454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944546003455 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 944546003456 MutS domain III; Region: MutS_III; cl17822 944546003457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546003458 Walker A/P-loop; other site 944546003459 ATP binding site [chemical binding]; other site 944546003460 Q-loop/lid; other site 944546003461 ABC transporter signature motif; other site 944546003462 Walker B; other site 944546003463 D-loop; other site 944546003464 H-loop/switch region; other site 944546003465 Smr domain; Region: Smr; pfam01713 944546003466 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 944546003467 Domain of unknown function DUF21; Region: DUF21; pfam01595 944546003468 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 944546003469 Transporter associated domain; Region: CorC_HlyC; smart01091 944546003470 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 944546003471 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 944546003472 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 944546003473 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 944546003474 metal binding site [ion binding]; metal-binding site 944546003475 dimer interface [polypeptide binding]; other site 944546003476 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 944546003477 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 944546003478 Nitrogen regulatory protein P-II; Region: P-II; smart00938 944546003479 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 944546003480 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 944546003481 exopolyphosphatase; Region: exo_poly_only; TIGR03706 944546003482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 944546003483 nucleotide binding site [chemical binding]; other site 944546003484 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 944546003485 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 944546003486 PYR/PP interface [polypeptide binding]; other site 944546003487 dimer interface [polypeptide binding]; other site 944546003488 TPP binding site [chemical binding]; other site 944546003489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 944546003490 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 944546003491 TPP-binding site [chemical binding]; other site 944546003492 dimer interface [polypeptide binding]; other site 944546003493 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 944546003494 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 944546003495 putative valine binding site [chemical binding]; other site 944546003496 dimer interface [polypeptide binding]; other site 944546003497 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 944546003498 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 944546003499 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 944546003500 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 944546003501 trimer interface [polypeptide binding]; other site 944546003502 active site 944546003503 UDP-GlcNAc binding site [chemical binding]; other site 944546003504 lipid binding site [chemical binding]; lipid-binding site 944546003505 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 944546003506 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 944546003507 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 944546003508 Response regulator receiver domain; Region: Response_reg; pfam00072 944546003509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003510 active site 944546003511 phosphorylation site [posttranslational modification] 944546003512 intermolecular recognition site; other site 944546003513 dimerization interface [polypeptide binding]; other site 944546003514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 944546003515 HAMP domain; Region: HAMP; pfam00672 944546003516 dimerization interface [polypeptide binding]; other site 944546003517 SEC-C motif; Region: SEC-C; pfam02810 944546003518 hypothetical protein; Provisional; Region: PRK04233 944546003519 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 944546003520 30S subunit binding site; other site 944546003521 GTP-binding protein Der; Reviewed; Region: PRK00093 944546003522 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 944546003523 G1 box; other site 944546003524 GTP/Mg2+ binding site [chemical binding]; other site 944546003525 Switch I region; other site 944546003526 G2 box; other site 944546003527 Switch II region; other site 944546003528 G3 box; other site 944546003529 G4 box; other site 944546003530 G5 box; other site 944546003531 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 944546003532 G1 box; other site 944546003533 GTP/Mg2+ binding site [chemical binding]; other site 944546003534 Switch I region; other site 944546003535 G2 box; other site 944546003536 G3 box; other site 944546003537 Switch II region; other site 944546003538 G4 box; other site 944546003539 G5 box; other site 944546003540 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 944546003541 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 944546003542 Sulfate transporter family; Region: Sulfate_transp; pfam00916 944546003543 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 944546003544 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 944546003545 active site 944546003546 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 944546003547 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 944546003548 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 944546003549 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 944546003550 RDD family; Region: RDD; pfam06271 944546003551 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 944546003552 Organic solvent tolerance protein; Region: OstA_C; pfam04453 944546003553 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546003554 active site 944546003555 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 944546003556 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 944546003557 oligomer interface [polypeptide binding]; other site 944546003558 RNA binding site [nucleotide binding]; other site 944546003559 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 944546003560 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 944546003561 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 944546003562 RNase E interface [polypeptide binding]; other site 944546003563 trimer interface [polypeptide binding]; other site 944546003564 active site 944546003565 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 944546003566 putative nucleic acid binding region [nucleotide binding]; other site 944546003567 G-X-X-G motif; other site 944546003568 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944546003569 RNA binding site [nucleotide binding]; other site 944546003570 Response regulator receiver domain; Region: Response_reg; pfam00072 944546003571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003572 active site 944546003573 phosphorylation site [posttranslational modification] 944546003574 intermolecular recognition site; other site 944546003575 dimerization interface [polypeptide binding]; other site 944546003576 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 944546003577 putative binding surface; other site 944546003578 active site 944546003579 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 944546003580 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 944546003581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003582 ATP binding site [chemical binding]; other site 944546003583 Mg2+ binding site [ion binding]; other site 944546003584 G-X-G motif; other site 944546003585 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 944546003586 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 944546003587 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 944546003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003589 CheD chemotactic sensory transduction; Region: CheD; cl00810 944546003590 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 944546003591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003592 active site 944546003593 phosphorylation site [posttranslational modification] 944546003594 intermolecular recognition site; other site 944546003595 dimerization interface [polypeptide binding]; other site 944546003596 CheB methylesterase; Region: CheB_methylest; pfam01339 944546003597 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 944546003598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546003599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546003600 putative substrate translocation pore; other site 944546003601 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944546003602 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 944546003603 active site 944546003604 DNA binding site [nucleotide binding] 944546003605 Int/Topo IB signature motif; other site 944546003606 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 944546003607 putative active site [active] 944546003608 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 944546003609 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 944546003610 active site 944546003611 Zn binding site [ion binding]; other site 944546003612 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 944546003613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003614 S-adenosylmethionine binding site [chemical binding]; other site 944546003615 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 944546003616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546003617 FeS/SAM binding site; other site 944546003618 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 944546003619 putative active site [active] 944546003620 Ap4A binding site [chemical binding]; other site 944546003621 nudix motif; other site 944546003622 putative metal binding site [ion binding]; other site 944546003623 aspartate kinase; Reviewed; Region: PRK06635 944546003624 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 944546003625 putative nucleotide binding site [chemical binding]; other site 944546003626 putative catalytic residues [active] 944546003627 putative Mg ion binding site [ion binding]; other site 944546003628 putative aspartate binding site [chemical binding]; other site 944546003629 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 944546003630 putative allosteric regulatory site; other site 944546003631 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 944546003632 DNA replication regulator; Region: HobA; pfam12163 944546003633 DNA polymerase III subunit delta'; Validated; Region: PRK08485 944546003634 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 944546003635 dihydropteroate synthase; Region: DHPS; TIGR01496 944546003636 substrate binding pocket [chemical binding]; other site 944546003637 dimer interface [polypeptide binding]; other site 944546003638 inhibitor binding site; inhibition site 944546003639 prephenate dehydrogenase; Validated; Region: PRK08507 944546003640 Prephenate dehydrogenase; Region: PDH; pfam02153 944546003641 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 944546003642 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944546003643 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944546003644 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 944546003645 Surface antigen; Region: Bac_surface_Ag; pfam01103 944546003646 hypothetical protein; Provisional; Region: PRK08445 944546003647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546003648 FeS/SAM binding site; other site 944546003649 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 944546003650 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 944546003651 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 944546003652 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 944546003653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944546003654 active site 944546003655 HIGH motif; other site 944546003656 nucleotide binding site [chemical binding]; other site 944546003657 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 944546003658 active site 944546003659 KMSKS motif; other site 944546003660 YGGT family; Region: YGGT; pfam02325 944546003661 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 944546003662 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 944546003663 N-acetyl-D-glucosamine binding site [chemical binding]; other site 944546003664 catalytic residue [active] 944546003665 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 944546003666 Walker A motif; other site 944546003667 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 944546003668 AMP binding site [chemical binding]; other site 944546003669 metal binding site [ion binding]; metal-binding site 944546003670 active site 944546003671 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 944546003672 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 944546003673 active site 944546003674 HIGH motif; other site 944546003675 KMSKS motif; other site 944546003676 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 944546003677 anticodon binding site; other site 944546003678 tRNA binding surface [nucleotide binding]; other site 944546003679 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 944546003680 dimer interface [polypeptide binding]; other site 944546003681 putative tRNA-binding site [nucleotide binding]; other site 944546003682 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 944546003683 Predicted transcriptional regulator [Transcription]; Region: COG2932 944546003684 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 944546003685 Catalytic site [active] 944546003686 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 944546003687 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 944546003688 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 944546003689 active site 944546003690 catalytic residues [active] 944546003691 metal binding site [ion binding]; metal-binding site 944546003692 homodimer binding site [polypeptide binding]; other site 944546003693 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 944546003694 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 944546003695 carboxyltransferase (CT) interaction site; other site 944546003696 biotinylation site [posttranslational modification]; other site 944546003697 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 944546003698 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 944546003699 active site 944546003700 substrate-binding site [chemical binding]; other site 944546003701 metal-binding site [ion binding] 944546003702 ATP binding site [chemical binding]; other site 944546003703 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 944546003704 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 944546003705 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 944546003706 active site 944546003707 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 944546003708 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 944546003709 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 944546003710 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 944546003711 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 944546003712 dimerization interface [polypeptide binding]; other site 944546003713 active site 944546003714 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 944546003715 dimer interface [polypeptide binding]; other site 944546003716 active site 944546003717 Schiff base residues; other site 944546003718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546003719 PAS domain; Region: PAS_9; pfam13426 944546003720 putative active site [active] 944546003721 heme pocket [chemical binding]; other site 944546003722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003724 ATP binding site [chemical binding]; other site 944546003725 Mg2+ binding site [ion binding]; other site 944546003726 G-X-G motif; other site 944546003727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003729 active site 944546003730 phosphorylation site [posttranslational modification] 944546003731 intermolecular recognition site; other site 944546003732 dimerization interface [polypeptide binding]; other site 944546003733 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546003734 DNA binding site [nucleotide binding] 944546003735 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 944546003736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546003737 FeS/SAM binding site; other site 944546003738 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 944546003739 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 944546003740 ATP cone domain; Region: ATP-cone; pfam03477 944546003741 Class III ribonucleotide reductase; Region: RNR_III; cd01675 944546003742 effector binding site; other site 944546003743 active site 944546003744 Zn binding site [ion binding]; other site 944546003745 ornithine carbamoyltransferase; Provisional; Region: PRK00779 944546003746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 944546003747 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 944546003748 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 944546003749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546003750 FeS/SAM binding site; other site 944546003751 HemN C-terminal domain; Region: HemN_C; pfam06969 944546003752 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 944546003753 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 944546003754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546003755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546003756 catalytic residue [active] 944546003757 NAD synthetase; Provisional; Region: PRK13980 944546003758 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 944546003759 homodimer interface [polypeptide binding]; other site 944546003760 NAD binding pocket [chemical binding]; other site 944546003761 ATP binding pocket [chemical binding]; other site 944546003762 Mg binding site [ion binding]; other site 944546003763 active-site loop [active] 944546003764 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 944546003765 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 944546003766 putative metal binding site [ion binding]; other site 944546003767 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944546003768 HSP70 interaction site [polypeptide binding]; other site 944546003769 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 944546003770 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 944546003771 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 944546003772 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 944546003773 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 944546003774 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 944546003775 active site 944546003776 catalytic site [active] 944546003777 substrate binding site [chemical binding]; other site 944546003778 Competence protein; Region: Competence; pfam03772 944546003779 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 944546003780 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 944546003781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003782 S-adenosylmethionine binding site [chemical binding]; other site 944546003783 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 944546003784 putative active site pocket [active] 944546003785 dimerization interface [polypeptide binding]; other site 944546003786 putative catalytic residue [active] 944546003787 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 944546003788 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 944546003789 Cysteine-rich domain; Region: CCG; pfam02754 944546003790 Cysteine-rich domain; Region: CCG; pfam02754 944546003791 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 944546003792 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546003793 DNA polymerase I; Provisional; Region: PRK05755 944546003794 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 944546003795 active site 944546003796 metal binding site 1 [ion binding]; metal-binding site 944546003797 putative 5' ssDNA interaction site; other site 944546003798 metal binding site 3; metal-binding site 944546003799 metal binding site 2 [ion binding]; metal-binding site 944546003800 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 944546003801 putative DNA binding site [nucleotide binding]; other site 944546003802 putative metal binding site [ion binding]; other site 944546003803 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 944546003804 active site 944546003805 catalytic site [active] 944546003806 substrate binding site [chemical binding]; other site 944546003807 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 944546003808 active site 944546003809 DNA binding site [nucleotide binding] 944546003810 catalytic site [active] 944546003811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 944546003812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 944546003813 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 944546003814 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 944546003815 Ligand binding site; other site 944546003816 oligomer interface; other site 944546003817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546003818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546003819 metal binding site [ion binding]; metal-binding site 944546003820 active site 944546003821 I-site; other site 944546003822 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546003823 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 944546003824 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 944546003825 Walker A/P-loop; other site 944546003826 ATP binding site [chemical binding]; other site 944546003827 Q-loop/lid; other site 944546003828 ABC transporter signature motif; other site 944546003829 Walker B; other site 944546003830 D-loop; other site 944546003831 H-loop/switch region; other site 944546003832 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 944546003833 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 944546003834 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 944546003835 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 944546003836 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 944546003837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546003838 RNA binding surface [nucleotide binding]; other site 944546003839 argininosuccinate synthase; Provisional; Region: PRK13820 944546003840 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 944546003841 ANP binding site [chemical binding]; other site 944546003842 Substrate Binding Site II [chemical binding]; other site 944546003843 Substrate Binding Site I [chemical binding]; other site 944546003844 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 944546003845 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 944546003846 acyl-activating enzyme (AAE) consensus motif; other site 944546003847 AMP binding site [chemical binding]; other site 944546003848 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 944546003849 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 944546003850 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 944546003851 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 944546003852 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 944546003853 trimer interface [polypeptide binding]; other site 944546003854 putative metal binding site [ion binding]; other site 944546003855 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 944546003856 TrkA-N domain; Region: TrkA_N; pfam02254 944546003857 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 944546003858 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 944546003859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546003860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546003861 active site 944546003862 dimerization interface [polypeptide binding]; other site 944546003863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546003864 DNA binding site [nucleotide binding] 944546003865 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 944546003866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546003867 dimer interface [polypeptide binding]; other site 944546003868 phosphorylation site [posttranslational modification] 944546003869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546003870 ATP binding site [chemical binding]; other site 944546003871 Mg2+ binding site [ion binding]; other site 944546003872 G-X-G motif; other site 944546003873 dUTPase; Region: dUTPase_2; pfam08761 944546003874 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 944546003875 active site 944546003876 homodimer interface [polypeptide binding]; other site 944546003877 metal binding site [ion binding]; metal-binding site 944546003878 recombination protein RecR; Reviewed; Region: recR; PRK00076 944546003879 RecR protein; Region: RecR; pfam02132 944546003880 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 944546003881 putative active site [active] 944546003882 putative metal-binding site [ion binding]; other site 944546003883 tetramer interface [polypeptide binding]; other site 944546003884 chaperone protein DnaJ; Provisional; Region: PRK10767 944546003885 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944546003886 HSP70 interaction site [polypeptide binding]; other site 944546003887 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 944546003888 Zn binding sites [ion binding]; other site 944546003889 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 944546003890 dimer interface [polypeptide binding]; other site 944546003891 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 944546003892 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 944546003893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546003894 catalytic residue [active] 944546003895 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 944546003896 dinuclear metal binding motif [ion binding]; other site 944546003897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 944546003898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546003899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546003900 metal binding site [ion binding]; metal-binding site 944546003901 active site 944546003902 I-site; other site 944546003903 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546003904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546003905 metal binding site [ion binding]; metal-binding site 944546003906 active site 944546003907 I-site; other site 944546003908 Methyltransferase domain; Region: Methyltransf_31; pfam13847 944546003909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546003910 S-adenosylmethionine binding site [chemical binding]; other site 944546003911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 944546003912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 944546003913 ResB-like family; Region: ResB; pfam05140 944546003914 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 944546003915 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 944546003916 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 944546003917 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 944546003918 metal binding site [ion binding]; metal-binding site 944546003919 diacylglycerol kinase/D-erythro-sphingosine kinase; Region: PLN02958 944546003920 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546003921 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546003922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546003923 dimer interface [polypeptide binding]; other site 944546003924 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546003925 putative CheW interface [polypeptide binding]; other site 944546003926 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 944546003927 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 944546003928 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 944546003929 DEAD/DEAH box helicase; Region: DEAD; pfam00270 944546003930 ATP binding site [chemical binding]; other site 944546003931 putative Mg++ binding site [ion binding]; other site 944546003932 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 944546003933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546003934 nucleotide binding region [chemical binding]; other site 944546003935 ATP-binding site [chemical binding]; other site 944546003936 SEC-C motif; Region: SEC-C; pfam02810 944546003937 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 944546003938 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 944546003939 FtsX-like permease family; Region: FtsX; pfam02687 944546003940 Protein of unknown function; Region: DUF3971; pfam13116 944546003941 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 944546003942 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 944546003943 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 944546003944 dimerization interface [polypeptide binding]; other site 944546003945 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 944546003946 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 944546003947 malate dehydrogenase; Reviewed; Region: PRK06223 944546003948 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 944546003949 NAD(P) binding site [chemical binding]; other site 944546003950 dimer interface [polypeptide binding]; other site 944546003951 tetramer (dimer of dimers) interface [polypeptide binding]; other site 944546003952 substrate binding site [chemical binding]; other site 944546003953 Cytochrome c; Region: Cytochrom_C; cl11414 944546003954 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 944546003955 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 944546003956 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 944546003957 NlpC/P60 family; Region: NLPC_P60; cl17555 944546003958 MraW methylase family; Region: Methyltransf_5; cl17771 944546003959 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 944546003960 hypothetical protein; Provisional; Region: PRK05834 944546003961 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 944546003962 IHF dimer interface [polypeptide binding]; other site 944546003963 IHF - DNA interface [nucleotide binding]; other site 944546003964 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 944546003965 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 944546003966 Rubredoxin; Region: Rubredoxin; pfam00301 944546003967 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 944546003968 iron binding site [ion binding]; other site 944546003969 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 944546003970 14-3-3 domain; Region: 14-3-3; cl02098 944546003971 peptide binding site [polypeptide binding]; other site 944546003972 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 944546003973 active site 944546003974 Zn binding site [ion binding]; other site 944546003975 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 944546003976 Fic/DOC family; Region: Fic; cl00960 944546003977 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 944546003978 conjugal transfer protein TraL; Provisional; Region: PRK13886 944546003979 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 944546003980 Helix-turn-helix domain; Region: HTH_17; pfam12728 944546003981 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 944546003982 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 944546003983 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 944546003984 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944546003985 active site 944546003986 catalytic residues [active] 944546003987 DNA binding site [nucleotide binding] 944546003988 Int/Topo IB signature motif; other site 944546003989 Rrf2 family protein; Region: rrf2_super; TIGR00738 944546003990 Transcriptional regulator; Region: Rrf2; pfam02082 944546003991 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 944546003992 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 944546003993 Binuclear center (active site) [active] 944546003994 K-pathway; other site 944546003995 Putative proton exit pathway; other site 944546003996 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 944546003997 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944546003998 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 944546003999 Response regulator receiver domain; Region: Response_reg; pfam00072 944546004000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004001 active site 944546004002 phosphorylation site [posttranslational modification] 944546004003 intermolecular recognition site; other site 944546004004 dimerization interface [polypeptide binding]; other site 944546004005 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 944546004006 PAS fold; Region: PAS; pfam00989 944546004007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944546004008 putative active site [active] 944546004009 heme pocket [chemical binding]; other site 944546004010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 944546004011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944546004013 dimer interface [polypeptide binding]; other site 944546004014 phosphorylation site [posttranslational modification] 944546004015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004016 ATP binding site [chemical binding]; other site 944546004017 Mg2+ binding site [ion binding]; other site 944546004018 G-X-G motif; other site 944546004019 chaperone protein DnaJ; Provisional; Region: PRK14299 944546004020 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 944546004021 HSP70 interaction site [polypeptide binding]; other site 944546004022 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 944546004023 substrate binding site [polypeptide binding]; other site 944546004024 dimer interface [polypeptide binding]; other site 944546004025 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 944546004026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 944546004027 DNA binding residues [nucleotide binding] 944546004028 putative dimer interface [polypeptide binding]; other site 944546004029 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 944546004030 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546004031 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 944546004032 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944546004033 Walker A/P-loop; other site 944546004034 ATP binding site [chemical binding]; other site 944546004035 Q-loop/lid; other site 944546004036 ABC transporter signature motif; other site 944546004037 Walker B; other site 944546004038 D-loop; other site 944546004039 H-loop/switch region; other site 944546004040 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 944546004041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944546004042 Walker A/P-loop; other site 944546004043 ATP binding site [chemical binding]; other site 944546004044 Q-loop/lid; other site 944546004045 ABC transporter signature motif; other site 944546004046 Walker B; other site 944546004047 D-loop; other site 944546004048 H-loop/switch region; other site 944546004049 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944546004050 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 944546004051 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 944546004052 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 944546004053 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 944546004054 hypothetical protein; Provisional; Region: PRK14013 944546004055 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 944546004056 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 944546004057 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 944546004058 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944546004059 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944546004060 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 944546004061 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 944546004062 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944546004063 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 944546004064 IMP binding site; other site 944546004065 dimer interface [polypeptide binding]; other site 944546004066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 944546004067 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 944546004068 NodB motif; other site 944546004069 putative active site [active] 944546004070 putative catalytic site [active] 944546004071 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 944546004072 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 944546004073 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 944546004074 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 944546004075 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944546004076 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546004077 N-terminal plug; other site 944546004078 ligand-binding site [chemical binding]; other site 944546004079 cell division protein FtsZ; Region: ftsZ; TIGR00065 944546004080 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 944546004081 nucleotide binding site [chemical binding]; other site 944546004082 SulA interaction site; other site 944546004083 cell division protein FtsA; Region: ftsA; TIGR01174 944546004084 Cell division protein FtsA; Region: FtsA; smart00842 944546004085 Cell division protein FtsA; Region: FtsA; pfam14450 944546004086 SurA N-terminal domain; Region: SurA_N_3; cl07813 944546004087 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 944546004088 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 944546004089 AAA domain; Region: AAA_30; pfam13604 944546004090 Family description; Region: UvrD_C_2; pfam13538 944546004091 adenylosuccinate synthetase; Provisional; Region: PTZ00350 944546004092 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 944546004093 ArsC family; Region: ArsC; pfam03960 944546004094 catalytic residues [active] 944546004095 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 944546004096 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 944546004097 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 944546004098 putative active site [active] 944546004099 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 944546004100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944546004101 ABC transporter; Region: ABC_tran_2; pfam12848 944546004102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 944546004103 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 944546004104 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 944546004105 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 944546004106 putative trimer interface [polypeptide binding]; other site 944546004107 putative CoA binding site [chemical binding]; other site 944546004108 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 944546004109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546004110 motif II; other site 944546004111 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 944546004112 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 944546004113 primosome assembly protein PriA; Validated; Region: PRK05580 944546004114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546004115 ATP binding site [chemical binding]; other site 944546004116 putative Mg++ binding site [ion binding]; other site 944546004117 helicase superfamily c-terminal domain; Region: HELICc; smart00490 944546004118 ATP-binding site [chemical binding]; other site 944546004119 proteasome-activating nucleotidase; Provisional; Region: PRK03992 944546004120 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 944546004121 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 944546004122 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 944546004123 dimerization interface [polypeptide binding]; other site 944546004124 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 944546004125 ATP binding site [chemical binding]; other site 944546004126 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 944546004127 homodimer interface [polypeptide binding]; other site 944546004128 chemical substrate binding site [chemical binding]; other site 944546004129 oligomer interface [polypeptide binding]; other site 944546004130 metal binding site [ion binding]; metal-binding site 944546004131 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 944546004132 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 944546004133 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 944546004134 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 944546004135 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 944546004136 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 944546004137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 944546004138 G1 box; other site 944546004139 GTP/Mg2+ binding site [chemical binding]; other site 944546004140 G2 box; other site 944546004141 Switch I region; other site 944546004142 G3 box; other site 944546004143 Switch II region; other site 944546004144 G4 box; other site 944546004145 G5 box; other site 944546004146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546004147 dimer interface [polypeptide binding]; other site 944546004148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546004149 putative CheW interface [polypeptide binding]; other site 944546004150 Uncharacterized conserved protein [Function unknown]; Region: COG1284 944546004151 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 944546004152 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 944546004153 flavoprotein, HI0933 family; Region: TIGR00275 944546004154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944546004155 Protein of unknown function (DUF808); Region: DUF808; cl01002 944546004156 Protein of unknown function, DUF481; Region: DUF481; pfam04338 944546004157 integral membrane protein; Region: integ_memb_HG; TIGR03954 944546004158 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 944546004159 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 944546004160 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 944546004161 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 944546004162 Ligand Binding Site [chemical binding]; other site 944546004163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546004164 active site residue [active] 944546004165 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 944546004166 Acylphosphatase; Region: Acylphosphatase; pfam00708 944546004167 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 944546004168 HypF finger; Region: zf-HYPF; pfam07503 944546004169 HypF finger; Region: zf-HYPF; pfam07503 944546004170 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 944546004171 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 944546004172 nickel binding site [ion binding]; other site 944546004173 putative substrate-binding site; other site 944546004174 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 944546004175 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 944546004176 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 944546004177 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 944546004178 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 944546004179 fec operon regulator FecR; Reviewed; Region: PRK09774 944546004180 FecR protein; Region: FecR; pfam04773 944546004181 RNA polymerase sigma factor; Reviewed; Region: PRK12527 944546004182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546004183 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 944546004184 DNA binding residues [nucleotide binding] 944546004185 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 944546004186 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 944546004187 putative substrate-binding site; other site 944546004188 nickel binding site [ion binding]; other site 944546004189 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 944546004190 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 944546004191 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 944546004192 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 944546004193 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 944546004194 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 944546004195 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 944546004196 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 944546004197 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 944546004198 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 944546004199 substrate binding site [chemical binding]; other site 944546004200 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 944546004201 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 944546004202 substrate binding site [chemical binding]; other site 944546004203 ligand binding site [chemical binding]; other site 944546004204 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 944546004205 PAS fold; Region: PAS; pfam00989 944546004206 PAS domain; Region: PAS; smart00091 944546004207 putative active site [active] 944546004208 heme pocket [chemical binding]; other site 944546004209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546004210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546004211 metal binding site [ion binding]; metal-binding site 944546004212 active site 944546004213 I-site; other site 944546004214 hypothetical protein; Provisional; Region: PRK12378 944546004215 VacJ like lipoprotein; Region: VacJ; cl01073 944546004216 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 944546004217 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 944546004218 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 944546004219 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 944546004220 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 944546004221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546004222 motif II; other site 944546004223 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 944546004224 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944546004225 catalytic residues [active] 944546004226 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 944546004227 Thioredoxin; Region: Thioredoxin_4; cl17273 944546004228 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 944546004229 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 944546004230 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 944546004231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 944546004232 active site 944546004233 RNA polymerase sigma factor; Reviewed; Region: PRK12527 944546004234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546004235 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 944546004236 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546004237 FecR protein; Region: FecR; pfam04773 944546004238 Secretin and TonB N terminus short domain; Region: STN; smart00965 944546004239 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546004240 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546004241 N-terminal plug; other site 944546004242 ligand-binding site [chemical binding]; other site 944546004243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546004244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546004245 metal binding site [ion binding]; metal-binding site 944546004246 active site 944546004247 I-site; other site 944546004248 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 944546004249 diiron binding motif [ion binding]; other site 944546004250 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 944546004251 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 944546004252 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 944546004253 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 944546004254 TrkA-N domain; Region: TrkA_N; pfam02254 944546004255 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 944546004256 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 944546004257 dimer interface [polypeptide binding]; other site 944546004258 active site 944546004259 glycine-pyridoxal phosphate binding site [chemical binding]; other site 944546004260 folate binding site [chemical binding]; other site 944546004261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546004262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944546004263 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 944546004264 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 944546004265 DNA binding site [nucleotide binding] 944546004266 active site 944546004267 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 944546004268 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 944546004269 minor groove reading motif; other site 944546004270 helix-hairpin-helix signature motif; other site 944546004271 substrate binding pocket [chemical binding]; other site 944546004272 active site 944546004273 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 944546004274 RNA/DNA hybrid binding site [nucleotide binding]; other site 944546004275 active site 944546004276 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 944546004277 acetylornithine aminotransferase; Provisional; Region: PRK02627 944546004278 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944546004279 inhibitor-cofactor binding pocket; inhibition site 944546004280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546004281 catalytic residue [active] 944546004282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 944546004283 MOSC domain; Region: MOSC; pfam03473 944546004284 lipoyl synthase; Provisional; Region: PRK05481 944546004285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546004286 FeS/SAM binding site; other site 944546004287 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 944546004288 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 944546004289 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 944546004290 dimer interface [polypeptide binding]; other site 944546004291 TPP-binding site [chemical binding]; other site 944546004292 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 944546004293 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944546004294 E3 interaction surface; other site 944546004295 lipoyl attachment site [posttranslational modification]; other site 944546004296 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 944546004297 E3 interaction surface; other site 944546004298 lipoyl attachment site [posttranslational modification]; other site 944546004299 e3 binding domain; Region: E3_binding; pfam02817 944546004300 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 944546004301 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 944546004302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944546004303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944546004304 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 944546004305 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 944546004306 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 944546004307 catalytic triad [active] 944546004308 Secretin and TonB N terminus short domain; Region: STN; pfam07660 944546004309 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944546004310 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546004311 N-terminal plug; other site 944546004312 ligand-binding site [chemical binding]; other site 944546004313 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 944546004314 active site 944546004315 catalytic residues [active] 944546004316 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 944546004317 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 944546004318 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944546004319 ATP binding site [chemical binding]; other site 944546004320 Mg++ binding site [ion binding]; other site 944546004321 motif III; other site 944546004322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546004323 nucleotide binding region [chemical binding]; other site 944546004324 ATP-binding site [chemical binding]; other site 944546004325 uncharacterized domain; Region: TIGR00702 944546004326 YcaO-like family; Region: YcaO; pfam02624 944546004327 Domain of unknown function DUF302; Region: DUF302; cl01364 944546004328 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 944546004329 Nitrate and nitrite sensing; Region: NIT; pfam08376 944546004330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546004331 dimer interface [polypeptide binding]; other site 944546004332 putative CheW interface [polypeptide binding]; other site 944546004333 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 944546004334 RNA/DNA hybrid binding site [nucleotide binding]; other site 944546004335 active site 944546004336 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 944546004337 active site 944546004338 catalytic residues [active] 944546004339 metal binding site [ion binding]; metal-binding site 944546004340 putative monooxygenase; Provisional; Region: PRK11118 944546004341 Protein of unknown function, DUF417; Region: DUF417; cl01162 944546004342 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 944546004343 DNA polymerase IV; Validated; Region: PRK01810 944546004344 active site 944546004345 DNA binding site [nucleotide binding] 944546004346 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 944546004347 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 944546004348 dimer interface [polypeptide binding]; other site 944546004349 putative functional site; other site 944546004350 putative MPT binding site; other site 944546004351 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546004352 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 944546004353 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 944546004354 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 944546004355 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 944546004356 4Fe-4S binding domain; Region: Fer4; cl02805 944546004357 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546004358 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546004359 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 944546004360 molybdopterin cofactor binding site; other site 944546004361 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546004362 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 944546004363 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944546004364 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 944546004365 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 944546004366 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 944546004367 putative ligand binding site [chemical binding]; other site 944546004368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004370 ATP binding site [chemical binding]; other site 944546004371 Mg2+ binding site [ion binding]; other site 944546004372 G-X-G motif; other site 944546004373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004374 Response regulator receiver domain; Region: Response_reg; pfam00072 944546004375 active site 944546004376 phosphorylation site [posttranslational modification] 944546004377 intermolecular recognition site; other site 944546004378 dimerization interface [polypeptide binding]; other site 944546004379 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 944546004380 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 944546004381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 944546004382 metal-binding site [ion binding] 944546004383 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944546004384 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944546004385 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 944546004386 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 944546004387 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 944546004388 4Fe-4S binding domain; Region: Fer4; cl02805 944546004389 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 944546004390 [4Fe-4S] binding site [ion binding]; other site 944546004391 molybdopterin cofactor binding site; other site 944546004392 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 944546004393 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 944546004394 molybdopterin cofactor binding site; other site 944546004395 selenophosphate synthetase; Provisional; Region: PRK00943 944546004396 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 944546004397 dimerization interface [polypeptide binding]; other site 944546004398 putative ATP binding site [chemical binding]; other site 944546004399 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 944546004400 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 944546004401 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 944546004402 catalytic residue [active] 944546004403 TPR repeat; Region: TPR_11; pfam13414 944546004404 Sel1-like repeats; Region: SEL1; smart00671 944546004405 Sel1-like repeats; Region: SEL1; smart00671 944546004406 selenocysteine synthase; Provisional; Region: PRK04311 944546004407 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 944546004408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546004409 catalytic residue [active] 944546004410 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 944546004411 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 944546004412 G1 box; other site 944546004413 putative GEF interaction site [polypeptide binding]; other site 944546004414 GTP/Mg2+ binding site [chemical binding]; other site 944546004415 Switch I region; other site 944546004416 G2 box; other site 944546004417 G3 box; other site 944546004418 Switch II region; other site 944546004419 G4 box; other site 944546004420 G5 box; other site 944546004421 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 944546004422 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 944546004423 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 944546004424 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 944546004425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 944546004426 ATP binding site [chemical binding]; other site 944546004427 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546004428 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546004429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546004431 dimer interface [polypeptide binding]; other site 944546004432 phosphorylation site [posttranslational modification] 944546004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004434 ATP binding site [chemical binding]; other site 944546004435 Mg2+ binding site [ion binding]; other site 944546004436 G-X-G motif; other site 944546004437 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 944546004438 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 944546004439 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 944546004440 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 944546004441 putative active site [active] 944546004442 PhoH-like protein; Region: PhoH; cl17668 944546004443 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 944546004444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004445 PAS domain; Region: PAS_9; pfam13426 944546004446 putative active site [active] 944546004447 heme pocket [chemical binding]; other site 944546004448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546004449 metal binding site [ion binding]; metal-binding site 944546004450 active site 944546004451 I-site; other site 944546004452 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546004453 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 944546004454 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 944546004455 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 944546004456 GAF domain; Region: GAF_2; pfam13185 944546004457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004458 PAS domain; Region: PAS_9; pfam13426 944546004459 putative active site [active] 944546004460 heme pocket [chemical binding]; other site 944546004461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546004462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546004463 metal binding site [ion binding]; metal-binding site 944546004464 active site 944546004465 I-site; other site 944546004466 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 944546004467 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 944546004468 ATP binding site [chemical binding]; other site 944546004469 Mg++ binding site [ion binding]; other site 944546004470 motif III; other site 944546004471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546004472 nucleotide binding region [chemical binding]; other site 944546004473 ATP-binding site [chemical binding]; other site 944546004474 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 944546004475 putative RNA binding site [nucleotide binding]; other site 944546004476 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944546004477 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 944546004478 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 944546004479 heat shock protein 90; Provisional; Region: PRK05218 944546004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004481 ATP binding site [chemical binding]; other site 944546004482 Mg2+ binding site [ion binding]; other site 944546004483 G-X-G motif; other site 944546004484 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 944546004485 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 944546004486 dimer interface [polypeptide binding]; other site 944546004487 active site 944546004488 heme binding site [chemical binding]; other site 944546004489 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 944546004490 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546004491 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546004492 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546004493 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 944546004494 mce related protein; Region: MCE; pfam02470 944546004495 mce related protein; Region: MCE; pfam02470 944546004496 mce related protein; Region: MCE; pfam02470 944546004497 mce related protein; Region: MCE; pfam02470 944546004498 Paraquat-inducible protein A; Region: PqiA; pfam04403 944546004499 Paraquat-inducible protein A; Region: PqiA; pfam04403 944546004500 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 944546004501 heme-binding site [chemical binding]; other site 944546004502 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546004503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546004504 metal binding site [ion binding]; metal-binding site 944546004505 active site 944546004506 I-site; other site 944546004507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546004508 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 944546004509 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 944546004510 EamA-like transporter family; Region: EamA; pfam00892 944546004511 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 944546004512 putative deacylase active site [active] 944546004513 YceI-like domain; Region: YceI; cl01001 944546004514 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 944546004515 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 944546004516 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 944546004517 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 944546004518 conserved cys residue [active] 944546004519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944546004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546004521 S-adenosylmethionine binding site [chemical binding]; other site 944546004522 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546004523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546004524 N-terminal plug; other site 944546004525 ligand-binding site [chemical binding]; other site 944546004526 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546004527 FecR protein; Region: FecR; pfam04773 944546004528 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 944546004529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546004530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546004531 DNA binding residues [nucleotide binding] 944546004532 agmatinase; Region: agmatinase; TIGR01230 944546004533 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 944546004534 putative active site [active] 944546004535 Mn binding site [ion binding]; other site 944546004536 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 944546004537 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 944546004538 active site 944546004539 catalytic residues [active] 944546004540 metal binding site [ion binding]; metal-binding site 944546004541 Helix-turn-helix domain; Region: HTH_18; pfam12833 944546004542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546004543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 944546004544 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 944546004545 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 944546004546 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 944546004547 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 944546004548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 944546004549 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 944546004550 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 944546004551 DHHA2 domain; Region: DHHA2; pfam02833 944546004552 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 944546004553 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 944546004554 active site 944546004555 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 944546004556 Aspartase; Region: Aspartase; cd01357 944546004557 active sites [active] 944546004558 tetramer interface [polypeptide binding]; other site 944546004559 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 944546004560 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 944546004561 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 944546004562 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 944546004563 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 944546004564 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 944546004565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546004566 binding surface 944546004567 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 944546004568 TPR motif; other site 944546004569 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 944546004570 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 944546004571 ligand binding site [chemical binding]; other site 944546004572 translocation protein TolB; Provisional; Region: tolB; PRK04043 944546004573 TonB C terminal; Region: TonB_2; pfam13103 944546004574 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 944546004575 TolR protein; Region: tolR; TIGR02801 944546004576 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 944546004577 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 944546004578 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 944546004579 gamma subunit interface [polypeptide binding]; other site 944546004580 epsilon subunit interface [polypeptide binding]; other site 944546004581 LBP interface [polypeptide binding]; other site 944546004582 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 944546004583 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 944546004584 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 944546004585 alpha subunit interaction interface [polypeptide binding]; other site 944546004586 Walker A motif; other site 944546004587 ATP binding site [chemical binding]; other site 944546004588 Walker B motif; other site 944546004589 inhibitor binding site; inhibition site 944546004590 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 944546004591 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 944546004592 core domain interface [polypeptide binding]; other site 944546004593 delta subunit interface [polypeptide binding]; other site 944546004594 epsilon subunit interface [polypeptide binding]; other site 944546004595 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 944546004596 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 944546004597 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 944546004598 beta subunit interaction interface [polypeptide binding]; other site 944546004599 Walker A motif; other site 944546004600 ATP binding site [chemical binding]; other site 944546004601 Walker B motif; other site 944546004602 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 944546004603 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 944546004604 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 944546004605 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 944546004606 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 944546004607 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 944546004608 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 944546004609 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 944546004610 ParB-like nuclease domain; Region: ParB; smart00470 944546004611 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 944546004612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 944546004613 P-loop; other site 944546004614 Magnesium ion binding site [ion binding]; other site 944546004615 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 944546004616 Magnesium ion binding site [ion binding]; other site 944546004617 biotin--protein ligase; Provisional; Region: PRK08477 944546004618 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 944546004619 Predicted permeases [General function prediction only]; Region: COG0679 944546004620 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 944546004621 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 944546004622 putative active site [active] 944546004623 substrate binding site [chemical binding]; other site 944546004624 putative cosubstrate binding site; other site 944546004625 catalytic site [active] 944546004626 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 944546004627 substrate binding site [chemical binding]; other site 944546004628 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 944546004629 nucleotide binding site [chemical binding]; other site 944546004630 homotetrameric interface [polypeptide binding]; other site 944546004631 putative phosphate binding site [ion binding]; other site 944546004632 putative allosteric binding site; other site 944546004633 GTPase CgtA; Reviewed; Region: obgE; PRK12299 944546004634 GTP1/OBG; Region: GTP1_OBG; pfam01018 944546004635 Obg GTPase; Region: Obg; cd01898 944546004636 G1 box; other site 944546004637 GTP/Mg2+ binding site [chemical binding]; other site 944546004638 Switch I region; other site 944546004639 G2 box; other site 944546004640 G3 box; other site 944546004641 Switch II region; other site 944546004642 G4 box; other site 944546004643 G5 box; other site 944546004644 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 944546004645 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 944546004646 DNA primase; Validated; Region: dnaG; PRK05667 944546004647 CHC2 zinc finger; Region: zf-CHC2; pfam01807 944546004648 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 944546004649 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 944546004650 active site 944546004651 metal binding site [ion binding]; metal-binding site 944546004652 interdomain interaction site; other site 944546004653 ribonuclease III; Reviewed; Region: rnc; PRK00102 944546004654 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 944546004655 dimerization interface [polypeptide binding]; other site 944546004656 active site 944546004657 metal binding site [ion binding]; metal-binding site 944546004658 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 944546004659 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 944546004660 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 944546004661 Tetramer interface [polypeptide binding]; other site 944546004662 active site 944546004663 FMN-binding site [chemical binding]; other site 944546004664 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 944546004665 M48 family peptidase; Provisional; Region: PRK03001 944546004666 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 944546004667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 944546004668 catalytic core [active] 944546004669 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 944546004670 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 944546004671 trmE is a tRNA modification GTPase; Region: trmE; cd04164 944546004672 G1 box; other site 944546004673 GTP/Mg2+ binding site [chemical binding]; other site 944546004674 Switch I region; other site 944546004675 G2 box; other site 944546004676 Switch II region; other site 944546004677 G3 box; other site 944546004678 G4 box; other site 944546004679 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 944546004680 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 944546004681 membrane protein insertase; Provisional; Region: PRK01318 944546004682 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 944546004683 Haemolytic domain; Region: Haemolytic; pfam01809 944546004684 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 944546004685 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 944546004686 Clp amino terminal domain; Region: Clp_N; pfam02861 944546004687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546004688 Walker A motif; other site 944546004689 ATP binding site [chemical binding]; other site 944546004690 Walker B motif; other site 944546004691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546004692 Walker A motif; other site 944546004693 ATP binding site [chemical binding]; other site 944546004694 Walker B motif; other site 944546004695 arginine finger; other site 944546004696 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 944546004697 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 944546004698 RNA/DNA hybrid binding site [nucleotide binding]; other site 944546004699 active site 944546004700 Domain of unknown function DUF77; Region: DUF77; pfam01910 944546004701 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944546004702 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 944546004703 methionine sulfoxide reductase B; Provisional; Region: PRK05508 944546004704 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 944546004705 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 944546004706 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 944546004707 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 944546004708 putative active site [active] 944546004709 putative CoA binding site [chemical binding]; other site 944546004710 nudix motif; other site 944546004711 metal binding site [ion binding]; metal-binding site 944546004712 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 944546004713 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 944546004714 inhibitor-cofactor binding pocket; inhibition site 944546004715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546004716 catalytic residue [active] 944546004717 NMT1/THI5 like; Region: NMT1; pfam09084 944546004718 ATP phosphoribosyltransferase; Region: HisG; cl15266 944546004719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944546004720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546004721 substrate binding pocket [chemical binding]; other site 944546004722 membrane-bound complex binding site; other site 944546004723 hinge residues; other site 944546004724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004726 ATP binding site [chemical binding]; other site 944546004727 Mg2+ binding site [ion binding]; other site 944546004728 G-X-G motif; other site 944546004729 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 944546004730 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 944546004731 purine monophosphate binding site [chemical binding]; other site 944546004732 dimer interface [polypeptide binding]; other site 944546004733 putative catalytic residues [active] 944546004734 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 944546004735 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 944546004736 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 944546004737 dimerization interface [polypeptide binding]; other site 944546004738 ATP binding site [chemical binding]; other site 944546004739 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 944546004740 dimerization interface [polypeptide binding]; other site 944546004741 ATP binding site [chemical binding]; other site 944546004742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 944546004743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 944546004744 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944546004745 Peptidase family M23; Region: Peptidase_M23; pfam01551 944546004746 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 944546004747 homodecamer interface [polypeptide binding]; other site 944546004748 GTP cyclohydrolase I; Provisional; Region: PLN03044 944546004749 active site 944546004750 putative catalytic site residues [active] 944546004751 zinc binding site [ion binding]; other site 944546004752 GTP-CH-I/GFRP interaction surface; other site 944546004753 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 944546004754 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 944546004755 Cl binding site [ion binding]; other site 944546004756 oligomer interface [polypeptide binding]; other site 944546004757 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944546004758 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 944546004759 Type II/IV secretion system protein; Region: T2SE; pfam00437 944546004760 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 944546004761 Walker A motif; other site 944546004762 ATP binding site [chemical binding]; other site 944546004763 Walker B motif; other site 944546004764 GTPase Era; Reviewed; Region: era; PRK00089 944546004765 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 944546004766 G1 box; other site 944546004767 GTP/Mg2+ binding site [chemical binding]; other site 944546004768 Switch I region; other site 944546004769 G2 box; other site 944546004770 Switch II region; other site 944546004771 G3 box; other site 944546004772 G4 box; other site 944546004773 G5 box; other site 944546004774 KH domain; Region: KH_2; pfam07650 944546004775 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 944546004776 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 944546004777 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 944546004778 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 944546004779 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 944546004780 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 944546004781 Part of AAA domain; Region: AAA_19; pfam13245 944546004782 Family description; Region: UvrD_C_2; pfam13538 944546004783 AAA ATPase domain; Region: AAA_15; pfam13175 944546004784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546004785 Walker A/P-loop; other site 944546004786 ATP binding site [chemical binding]; other site 944546004787 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 944546004788 putative active site [active] 944546004789 putative metal-binding site [ion binding]; other site 944546004790 chromosome segregation protein; Provisional; Region: PRK03918 944546004791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546004792 ABC transporter signature motif; other site 944546004793 Walker B; other site 944546004794 D-loop; other site 944546004795 H-loop/switch region; other site 944546004796 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 944546004797 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 944546004798 active site 944546004799 metal binding site [ion binding]; metal-binding site 944546004800 DNA binding site [nucleotide binding] 944546004801 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 944546004802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 944546004803 ATP binding site [chemical binding]; other site 944546004804 putative Mg++ binding site [ion binding]; other site 944546004805 helicase superfamily c-terminal domain; Region: HELICc; smart00490 944546004806 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944546004807 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944546004808 active site 944546004809 catalytic residues [active] 944546004810 DNA binding site [nucleotide binding] 944546004811 Int/Topo IB signature motif; other site 944546004812 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 944546004813 Cache domain; Region: Cache_2; cl07034 944546004814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546004815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546004816 dimer interface [polypeptide binding]; other site 944546004817 putative CheW interface [polypeptide binding]; other site 944546004818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004819 PAS domain; Region: PAS_9; pfam13426 944546004820 putative active site [active] 944546004821 heme pocket [chemical binding]; other site 944546004822 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 944546004823 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 944546004824 active site 944546004825 catalytic residues [active] 944546004826 metal binding site [ion binding]; metal-binding site 944546004827 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 944546004828 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 944546004829 oligomer interface [polypeptide binding]; other site 944546004830 active site residues [active] 944546004831 trigger factor; Provisional; Region: tig; PRK01490 944546004832 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 944546004833 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 944546004834 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944546004835 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 944546004836 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 944546004837 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 944546004838 dimer interface [polypeptide binding]; other site 944546004839 active site 944546004840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944546004841 catalytic residues [active] 944546004842 substrate binding site [chemical binding]; other site 944546004843 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 944546004844 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 944546004845 NAD(P) binding pocket [chemical binding]; other site 944546004846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 944546004847 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 944546004848 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 944546004849 homodimer interface [polypeptide binding]; other site 944546004850 substrate-cofactor binding pocket; other site 944546004851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546004852 catalytic residue [active] 944546004853 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546004854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546004855 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 944546004856 catalytic residue [active] 944546004857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546004858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004859 active site 944546004860 phosphorylation site [posttranslational modification] 944546004861 intermolecular recognition site; other site 944546004862 dimerization interface [polypeptide binding]; other site 944546004863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546004864 DNA binding site [nucleotide binding] 944546004865 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 944546004866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546004867 dimer interface [polypeptide binding]; other site 944546004868 putative CheW interface [polypeptide binding]; other site 944546004869 Response regulator receiver domain; Region: Response_reg; pfam00072 944546004870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004871 active site 944546004872 phosphorylation site [posttranslational modification] 944546004873 intermolecular recognition site; other site 944546004874 dimerization interface [polypeptide binding]; other site 944546004875 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 944546004876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004877 active site 944546004878 phosphorylation site [posttranslational modification] 944546004879 intermolecular recognition site; other site 944546004880 PAS domain; Region: PAS_9; pfam13426 944546004881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004882 putative active site [active] 944546004883 heme pocket [chemical binding]; other site 944546004884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004885 PAS domain; Region: PAS_9; pfam13426 944546004886 putative active site [active] 944546004887 heme pocket [chemical binding]; other site 944546004888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546004889 Zn2+ binding site [ion binding]; other site 944546004890 Mg2+ binding site [ion binding]; other site 944546004891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546004892 dimer interface [polypeptide binding]; other site 944546004893 putative CheW interface [polypeptide binding]; other site 944546004894 NMT1/THI5 like; Region: NMT1; pfam09084 944546004895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546004896 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 944546004897 substrate binding pocket [chemical binding]; other site 944546004898 membrane-bound complex binding site; other site 944546004899 hinge residues; other site 944546004900 PAS domain S-box; Region: sensory_box; TIGR00229 944546004901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546004902 putative active site [active] 944546004903 heme pocket [chemical binding]; other site 944546004904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004906 ATP binding site [chemical binding]; other site 944546004907 Mg2+ binding site [ion binding]; other site 944546004908 G-X-G motif; other site 944546004909 Membrane transport protein; Region: Mem_trans; cl09117 944546004910 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944546004911 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 944546004912 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 944546004913 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944546004914 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944546004915 catalytic residues [active] 944546004916 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 944546004917 Cytochrome c; Region: Cytochrom_C; cl11414 944546004918 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944546004919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546004920 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546004921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 944546004922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 944546004923 Coenzyme A binding pocket [chemical binding]; other site 944546004924 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 944546004925 High-affinity nickel-transport protein; Region: NicO; cl00964 944546004926 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 944546004927 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 944546004928 putative metal binding residues [ion binding]; other site 944546004929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944546004930 metal binding site 2 [ion binding]; metal-binding site 944546004931 putative DNA binding helix; other site 944546004932 metal binding site 1 [ion binding]; metal-binding site 944546004933 dimer interface [polypeptide binding]; other site 944546004934 structural Zn2+ binding site [ion binding]; other site 944546004935 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 944546004936 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 944546004937 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 944546004938 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 944546004939 Imelysin; Region: Peptidase_M75; pfam09375 944546004940 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 944546004941 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 944546004942 Imelysin; Region: Peptidase_M75; cl09159 944546004943 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 944546004944 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 944546004945 dimer interface [polypeptide binding]; other site 944546004946 substrate binding site [chemical binding]; other site 944546004947 ATP binding site [chemical binding]; other site 944546004948 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 944546004949 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 944546004950 putative catalytic cysteine [active] 944546004951 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 944546004952 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 944546004953 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 944546004954 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944546004955 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 944546004956 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944546004957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546004958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944546004959 dimer interface [polypeptide binding]; other site 944546004960 phosphorylation site [posttranslational modification] 944546004961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546004962 ATP binding site [chemical binding]; other site 944546004963 Mg2+ binding site [ion binding]; other site 944546004964 G-X-G motif; other site 944546004965 Response regulator receiver domain; Region: Response_reg; pfam00072 944546004966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546004967 active site 944546004968 phosphorylation site [posttranslational modification] 944546004969 intermolecular recognition site; other site 944546004970 dimerization interface [polypeptide binding]; other site 944546004971 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546004972 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 944546004973 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 944546004974 DNA binding site [nucleotide binding] 944546004975 active site 944546004976 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 944546004977 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 944546004978 active site 944546004979 substrate binding site [chemical binding]; other site 944546004980 metal binding site [ion binding]; metal-binding site 944546004981 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 944546004982 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 944546004983 active site 944546004984 catalytic triad [active] 944546004985 dimer interface [polypeptide binding]; other site 944546004986 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 944546004987 catalytic residue [active] 944546004988 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 944546004989 flavodoxin FldA; Validated; Region: PRK09267 944546004990 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 944546004991 metal binding site 2 [ion binding]; metal-binding site 944546004992 putative DNA binding helix; other site 944546004993 metal binding site 1 [ion binding]; metal-binding site 944546004994 dimer interface [polypeptide binding]; other site 944546004995 structural Zn2+ binding site [ion binding]; other site 944546004996 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 944546004997 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 944546004998 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 944546004999 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 944546005000 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 944546005001 substrate binding site [chemical binding]; other site 944546005002 active site 944546005003 catalytic residues [active] 944546005004 heterodimer interface [polypeptide binding]; other site 944546005005 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 944546005006 active site 944546005007 oligomerization interface [polypeptide binding]; other site 944546005008 metal binding site [ion binding]; metal-binding site 944546005009 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 944546005010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546005011 Walker A motif; other site 944546005012 ATP binding site [chemical binding]; other site 944546005013 Walker B motif; other site 944546005014 arginine finger; other site 944546005015 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 944546005016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 944546005017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 944546005018 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 944546005019 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546005020 active site residue [active] 944546005021 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 944546005022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546005023 FeS/SAM binding site; other site 944546005024 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 944546005025 substrate binding site [chemical binding]; other site 944546005026 active site 944546005027 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 944546005028 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 944546005029 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 944546005030 DNA gyrase subunit A; Validated; Region: PRK05560 944546005031 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 944546005032 CAP-like domain; other site 944546005033 active site 944546005034 primary dimer interface [polypeptide binding]; other site 944546005035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 944546005041 Protein of unknown function (DUF465); Region: DUF465; cl01070 944546005042 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 944546005043 heterotetramer interface [polypeptide binding]; other site 944546005044 active site pocket [active] 944546005045 cleavage site 944546005046 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 944546005047 TrkA-N domain; Region: TrkA_N; pfam02254 944546005048 TrkA-C domain; Region: TrkA_C; pfam02080 944546005049 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 944546005050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944546005051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546005052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546005053 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 944546005054 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 944546005055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546005056 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 944546005057 NAD(P) binding site [chemical binding]; other site 944546005058 active site 944546005059 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 944546005060 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 944546005061 putative ribose interaction site [chemical binding]; other site 944546005062 putative ADP binding site [chemical binding]; other site 944546005063 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 944546005064 active site 944546005065 nucleotide binding site [chemical binding]; other site 944546005066 HIGH motif; other site 944546005067 KMSKS motif; other site 944546005068 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 944546005069 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 944546005070 dimer interface [polypeptide binding]; other site 944546005071 active site 944546005072 Sulfatase; Region: Sulfatase; pfam00884 944546005073 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 944546005074 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 944546005075 putative active site [active] 944546005076 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 944546005077 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 944546005078 putative active site [active] 944546005079 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 944546005080 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 944546005081 putative metal binding site; other site 944546005082 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 944546005083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 944546005084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 944546005085 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 944546005086 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546005087 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 944546005088 putative trimer interface [polypeptide binding]; other site 944546005089 putative CoA binding site [chemical binding]; other site 944546005090 O-Antigen ligase; Region: Wzy_C; cl04850 944546005091 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 944546005092 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 944546005093 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 944546005094 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 944546005095 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 944546005096 Probable Catalytic site; other site 944546005097 metal-binding site 944546005098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 944546005099 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 944546005100 active site 944546005101 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 944546005102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 944546005103 active site 944546005104 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 944546005105 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 944546005106 NAD binding site [chemical binding]; other site 944546005107 substrate binding site [chemical binding]; other site 944546005108 homodimer interface [polypeptide binding]; other site 944546005109 active site 944546005110 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 944546005111 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 944546005112 NADP binding site [chemical binding]; other site 944546005113 active site 944546005114 putative substrate binding site [chemical binding]; other site 944546005115 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 944546005116 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 944546005117 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 944546005118 substrate binding site; other site 944546005119 tetramer interface; other site 944546005120 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 944546005121 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 944546005122 putative active site [active] 944546005123 serine/threonine protein kinase; Provisional; Region: PRK14879 944546005124 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 944546005125 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 944546005126 putative acyl-acceptor binding pocket; other site 944546005127 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 944546005128 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 944546005129 putative active site [active] 944546005130 exopolyphosphatase; Region: exo_poly_only; TIGR03706 944546005131 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 944546005132 nucleotide binding site [chemical binding]; other site 944546005133 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 944546005134 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 944546005135 active site 944546005136 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 944546005137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 944546005138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944546005139 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 944546005140 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 944546005141 active site 944546005142 dimer interface [polypeptide binding]; other site 944546005143 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 944546005144 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 944546005145 active site 944546005146 FMN binding site [chemical binding]; other site 944546005147 substrate binding site [chemical binding]; other site 944546005148 3Fe-4S cluster binding site [ion binding]; other site 944546005149 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 944546005150 domain_subunit interface; other site 944546005151 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 944546005152 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 944546005153 Cache domain; Region: Cache_1; pfam02743 944546005154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546005155 dimer interface [polypeptide binding]; other site 944546005156 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546005157 putative CheW interface [polypeptide binding]; other site 944546005158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546005159 dimer interface [polypeptide binding]; other site 944546005160 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 944546005161 putative CheW interface [polypeptide binding]; other site 944546005162 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 944546005163 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 944546005164 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 944546005165 Uncharacterized conserved protein [Function unknown]; Region: COG1739 944546005166 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 944546005167 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 944546005168 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 944546005169 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 944546005170 RNA binding surface [nucleotide binding]; other site 944546005171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546005172 S-adenosylmethionine binding site [chemical binding]; other site 944546005173 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 944546005174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 944546005175 active site 944546005176 nucleotide binding site [chemical binding]; other site 944546005177 HIGH motif; other site 944546005178 KMSKS motif; other site 944546005179 Riboflavin kinase; Region: Flavokinase; pfam01687 944546005180 Methyltransferase domain; Region: Methyltransf_23; pfam13489 944546005181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546005182 S-adenosylmethionine binding site [chemical binding]; other site 944546005183 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 944546005184 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 944546005185 catalytic triad [active] 944546005186 FAD binding domain; Region: FAD_binding_4; pfam01565 944546005187 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 944546005188 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 944546005189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 944546005190 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 944546005191 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 944546005192 hinge; other site 944546005193 active site 944546005194 EamA-like transporter family; Region: EamA; cl17759 944546005195 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 944546005196 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 944546005197 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 944546005198 homopentamer interface [polypeptide binding]; other site 944546005199 active site 944546005200 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 944546005201 putative RNA binding site [nucleotide binding]; other site 944546005202 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 944546005203 active site 944546005204 dimer interface [polypeptide binding]; other site 944546005205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 944546005206 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 944546005207 Walker A/P-loop; other site 944546005208 ATP binding site [chemical binding]; other site 944546005209 Q-loop/lid; other site 944546005210 ABC transporter signature motif; other site 944546005211 Walker B; other site 944546005212 D-loop; other site 944546005213 H-loop/switch region; other site 944546005214 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 944546005215 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 944546005216 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 944546005217 G1 box; other site 944546005218 GTP/Mg2+ binding site [chemical binding]; other site 944546005219 Switch I region; other site 944546005220 G2 box; other site 944546005221 G3 box; other site 944546005222 Switch II region; other site 944546005223 G4 box; other site 944546005224 G5 box; other site 944546005225 Nucleoside recognition; Region: Gate; pfam07670 944546005226 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 944546005227 Nucleoside recognition; Region: Gate; pfam07670 944546005228 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 944546005229 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 944546005230 Heavy-metal-associated domain; Region: HMA; pfam00403 944546005231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 944546005232 metal-binding site [ion binding] 944546005233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 944546005234 Soluble P-type ATPase [General function prediction only]; Region: COG4087 944546005235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944546005236 dimerization interface [polypeptide binding]; other site 944546005237 putative DNA binding site [nucleotide binding]; other site 944546005238 putative Zn2+ binding site [ion binding]; other site 944546005239 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 944546005240 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546005241 N-terminal plug; other site 944546005242 ligand-binding site [chemical binding]; other site 944546005243 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 944546005244 Protein export membrane protein; Region: SecD_SecF; cl14618 944546005245 Protein export membrane protein; Region: SecD_SecF; cl14618 944546005246 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944546005247 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546005248 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 944546005249 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 944546005250 DNA-binding site [nucleotide binding]; DNA binding site 944546005251 RNA-binding motif; other site 944546005252 Response regulator receiver domain; Region: Response_reg; pfam00072 944546005253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546005254 active site 944546005255 phosphorylation site [posttranslational modification] 944546005256 intermolecular recognition site; other site 944546005257 dimerization interface [polypeptide binding]; other site 944546005258 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 944546005259 DNA binding site [nucleotide binding] 944546005260 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 944546005261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546005262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 944546005263 dimer interface [polypeptide binding]; other site 944546005264 phosphorylation site [posttranslational modification] 944546005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546005266 ATP binding site [chemical binding]; other site 944546005267 Mg2+ binding site [ion binding]; other site 944546005268 G-X-G motif; other site 944546005269 benzoate transporter; Region: benE; TIGR00843 944546005270 Benzoate membrane transport protein; Region: BenE; pfam03594 944546005271 YCII-related domain; Region: YCII; cl00999 944546005272 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 944546005273 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 944546005274 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 944546005275 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 944546005276 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 944546005277 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 944546005278 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 944546005279 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 944546005280 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 944546005281 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 944546005282 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 944546005283 DNA binding site [nucleotide binding] 944546005284 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 944546005285 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 944546005286 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 944546005287 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 944546005288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 944546005289 RPB3 interaction site [polypeptide binding]; other site 944546005290 RPB1 interaction site [polypeptide binding]; other site 944546005291 RPB11 interaction site [polypeptide binding]; other site 944546005292 RPB10 interaction site [polypeptide binding]; other site 944546005293 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 944546005294 L11 interface [polypeptide binding]; other site 944546005295 putative EF-Tu interaction site [polypeptide binding]; other site 944546005296 putative EF-G interaction site [polypeptide binding]; other site 944546005297 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 944546005298 23S rRNA interface [nucleotide binding]; other site 944546005299 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 944546005300 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 944546005301 mRNA/rRNA interface [nucleotide binding]; other site 944546005302 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 944546005303 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 944546005304 23S rRNA interface [nucleotide binding]; other site 944546005305 L7/L12 interface [polypeptide binding]; other site 944546005306 putative thiostrepton binding site; other site 944546005307 L25 interface [polypeptide binding]; other site 944546005308 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 944546005309 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 944546005310 putative homodimer interface [polypeptide binding]; other site 944546005311 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 944546005312 heterodimer interface [polypeptide binding]; other site 944546005313 homodimer interface [polypeptide binding]; other site 944546005314 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 944546005315 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 944546005316 elongation factor Tu; Reviewed; Region: PRK00049 944546005317 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 944546005318 G1 box; other site 944546005319 GEF interaction site [polypeptide binding]; other site 944546005320 GTP/Mg2+ binding site [chemical binding]; other site 944546005321 Switch I region; other site 944546005322 G2 box; other site 944546005323 G3 box; other site 944546005324 Switch II region; other site 944546005325 G4 box; other site 944546005326 G5 box; other site 944546005327 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 944546005328 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 944546005329 Antibiotic Binding Site [chemical binding]; other site 944546005330 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 944546005331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 944546005332 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 944546005333 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 944546005334 Mg++ binding site [ion binding]; other site 944546005335 putative catalytic motif [active] 944546005336 putative substrate binding site [chemical binding]; other site 944546005337 phosphoglyceromutase; Provisional; Region: PRK05434 944546005338 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 944546005339 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 944546005340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546005341 Walker A/P-loop; other site 944546005342 ATP binding site [chemical binding]; other site 944546005343 Q-loop/lid; other site 944546005344 ABC transporter signature motif; other site 944546005345 Walker B; other site 944546005346 D-loop; other site 944546005347 H-loop/switch region; other site 944546005348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 944546005349 Transglycosylase; Region: Transgly; pfam00912 944546005350 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 944546005351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 944546005352 glutamine synthetase, type I; Region: GlnA; TIGR00653 944546005353 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 944546005354 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 944546005355 histidinol-phosphatase; Provisional; Region: PRK07328 944546005356 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 944546005357 active site 944546005358 dimer interface [polypeptide binding]; other site 944546005359 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 944546005360 MoaE homodimer interface [polypeptide binding]; other site 944546005361 MoaD interaction [polypeptide binding]; other site 944546005362 active site residues [active] 944546005363 charged pocket; other site 944546005364 ThiS family; Region: ThiS; pfam02597 944546005365 hydrophobic patch; other site 944546005366 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 944546005367 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 944546005368 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 944546005369 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 944546005370 active site 944546005371 homodimer interface [polypeptide binding]; other site 944546005372 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 944546005373 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 944546005374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 944546005375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 944546005376 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 944546005377 active site 944546005378 Cytochrome c; Region: Cytochrom_C; cl11414 944546005379 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 944546005380 Clp amino terminal domain; Region: Clp_N; pfam02861 944546005381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546005382 Walker A motif; other site 944546005383 ATP binding site [chemical binding]; other site 944546005384 Walker B motif; other site 944546005385 arginine finger; other site 944546005386 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 944546005387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546005388 Walker A motif; other site 944546005389 ATP binding site [chemical binding]; other site 944546005390 Walker B motif; other site 944546005391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 944546005392 Uncharacterized conserved protein [Function unknown]; Region: COG2127 944546005393 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 944546005394 AAA domain; Region: AAA_26; pfam13500 944546005395 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 944546005396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 944546005397 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 944546005398 acyl-activating enzyme (AAE) consensus motif; other site 944546005399 AMP binding site [chemical binding]; other site 944546005400 active site 944546005401 CoA binding site [chemical binding]; other site 944546005402 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 944546005403 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 944546005404 putative active site [active] 944546005405 putative catalytic site [active] 944546005406 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 944546005407 putative active site [active] 944546005408 putative catalytic site [active] 944546005409 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 944546005410 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 944546005411 Fumarase C-terminus; Region: Fumerase_C; pfam05683 944546005412 Nitrate and nitrite sensing; Region: NIT; pfam08376 944546005413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546005414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546005415 dimer interface [polypeptide binding]; other site 944546005416 putative CheW interface [polypeptide binding]; other site 944546005417 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546005418 arsenical pump membrane protein; Provisional; Region: PRK15445 944546005419 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 944546005420 transmembrane helices; other site 944546005421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 944546005422 putative DNA binding site [nucleotide binding]; other site 944546005423 dimerization interface [polypeptide binding]; other site 944546005424 putative Zn2+ binding site [ion binding]; other site 944546005425 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 944546005426 Predicted permeases [General function prediction only]; Region: COG0701 944546005427 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 944546005428 Low molecular weight phosphatase family; Region: LMWPc; cd00115 944546005429 active site 944546005430 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 944546005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546005432 H+ Antiporter protein; Region: 2A0121; TIGR00900 944546005433 putative substrate translocation pore; other site 944546005434 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 944546005435 FHIPEP family; Region: FHIPEP; pfam00771 944546005436 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 944546005437 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944546005438 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 944546005439 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 944546005440 Walker A motif/ATP binding site; other site 944546005441 Walker B motif; other site 944546005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 944546005443 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 944546005444 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 944546005445 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 944546005446 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 944546005447 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 944546005448 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944546005449 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546005450 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 944546005451 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 944546005452 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944546005453 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944546005454 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 944546005455 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 944546005456 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 944546005457 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541 944546005458 flagellar motor switch protein FliY; Validated; Region: PRK08432 944546005459 flagellar motor switch protein FliN; Region: fliN; TIGR02480 944546005460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 944546005461 binding surface 944546005462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 944546005463 TPR motif; other site 944546005464 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 944546005465 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 944546005466 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546005467 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 944546005468 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546005469 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 944546005470 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 944546005471 Flagellar assembly protein FliH; Region: FliH; pfam02108 944546005472 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 944546005473 MgtE intracellular N domain; Region: MgtE_N; cl15244 944546005474 FliG C-terminal domain; Region: FliG_C; pfam01706 944546005475 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 944546005476 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 944546005477 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 944546005478 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 944546005479 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 944546005480 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 944546005481 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546005482 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 944546005483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546005484 active site 944546005485 phosphorylation site [posttranslational modification] 944546005486 intermolecular recognition site; other site 944546005487 dimerization interface [polypeptide binding]; other site 944546005488 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 944546005489 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 944546005490 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 944546005491 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 944546005492 RimM N-terminal domain; Region: RimM; pfam01782 944546005493 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 944546005494 KH domain; Region: KH_4; pfam13083 944546005495 G-X-X-G motif; other site 944546005496 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 944546005497 signal recognition particle protein; Provisional; Region: PRK10867 944546005498 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 944546005499 P loop; other site 944546005500 GTP binding site [chemical binding]; other site 944546005501 Signal peptide binding domain; Region: SRP_SPB; pfam02978 944546005502 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 944546005503 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 944546005504 active site 944546005505 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 944546005506 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 944546005507 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 944546005508 Putative zinc ribbon domain; Region: DUF164; pfam02591 944546005509 Uncharacterized conserved protein [Function unknown]; Region: COG0327 944546005510 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 944546005511 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 944546005512 dimer interface [polypeptide binding]; other site 944546005513 motif 1; other site 944546005514 active site 944546005515 motif 2; other site 944546005516 motif 3; other site 944546005517 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 944546005518 catalytic residues [active] 944546005519 AIR carboxylase; Region: AIRC; smart01001 944546005520 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 944546005521 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 944546005522 Peptidase family U32; Region: Peptidase_U32; pfam01136 944546005523 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 944546005524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944546005525 dimerization interface [polypeptide binding]; other site 944546005526 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 944546005527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546005528 dimer interface [polypeptide binding]; other site 944546005529 putative CheW interface [polypeptide binding]; other site 944546005530 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 944546005531 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 944546005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546005533 Walker A/P-loop; other site 944546005534 ATP binding site [chemical binding]; other site 944546005535 Q-loop/lid; other site 944546005536 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 944546005537 ABC transporter signature motif; other site 944546005538 Walker B; other site 944546005539 D-loop; other site 944546005540 H-loop/switch region; other site 944546005541 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 944546005542 ATP-NAD kinase; Region: NAD_kinase; pfam01513 944546005543 elongation factor G; Reviewed; Region: PRK00007 944546005544 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 944546005545 G1 box; other site 944546005546 putative GEF interaction site [polypeptide binding]; other site 944546005547 GTP/Mg2+ binding site [chemical binding]; other site 944546005548 Switch I region; other site 944546005549 G2 box; other site 944546005550 G3 box; other site 944546005551 Switch II region; other site 944546005552 G4 box; other site 944546005553 G5 box; other site 944546005554 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 944546005555 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 944546005556 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 944546005557 30S ribosomal protein S7; Validated; Region: PRK05302 944546005558 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 944546005559 S17 interaction site [polypeptide binding]; other site 944546005560 S8 interaction site; other site 944546005561 16S rRNA interaction site [nucleotide binding]; other site 944546005562 streptomycin interaction site [chemical binding]; other site 944546005563 23S rRNA interaction site [nucleotide binding]; other site 944546005564 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 944546005565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 944546005566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 944546005567 MFS transport protein AraJ; Provisional; Region: PRK10091 944546005568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546005569 putative substrate translocation pore; other site 944546005570 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 944546005571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546005572 N-terminal plug; other site 944546005573 ligand-binding site [chemical binding]; other site 944546005574 NMT1/THI5 like; Region: NMT1; pfam09084 944546005575 Protein of unknown function (DUF3834); Region: DUF3834; pfam12916 944546005576 NnrS protein; Region: NnrS; pfam05940 944546005577 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 944546005578 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 944546005579 Walker A/P-loop; other site 944546005580 ATP binding site [chemical binding]; other site 944546005581 Q-loop/lid; other site 944546005582 ABC transporter signature motif; other site 944546005583 Walker B; other site 944546005584 D-loop; other site 944546005585 H-loop/switch region; other site 944546005586 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 944546005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546005588 dimer interface [polypeptide binding]; other site 944546005589 conserved gate region; other site 944546005590 putative PBP binding loops; other site 944546005591 ABC-ATPase subunit interface; other site 944546005592 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 944546005593 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 944546005594 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 944546005595 glutamine binding [chemical binding]; other site 944546005596 catalytic triad [active] 944546005597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944546005598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944546005599 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 944546005600 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 944546005601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546005602 NAD(P) binding site [chemical binding]; other site 944546005603 active site 944546005604 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 944546005605 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 944546005606 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 944546005607 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 944546005608 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 944546005609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546005610 dimer interface [polypeptide binding]; other site 944546005611 conserved gate region; other site 944546005612 putative PBP binding loops; other site 944546005613 ABC-ATPase subunit interface; other site 944546005614 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 944546005615 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 944546005616 Walker A/P-loop; other site 944546005617 ATP binding site [chemical binding]; other site 944546005618 Q-loop/lid; other site 944546005619 ABC transporter signature motif; other site 944546005620 Walker B; other site 944546005621 D-loop; other site 944546005622 H-loop/switch region; other site 944546005623 TOBE domain; Region: TOBE_2; pfam08402 944546005624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546005625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944546005626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546005627 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546005628 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546005629 N-terminal plug; other site 944546005630 ligand-binding site [chemical binding]; other site 944546005631 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 944546005632 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 944546005633 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 944546005634 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 944546005635 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944546005636 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944546005637 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 944546005638 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 944546005639 metal binding site [ion binding]; metal-binding site 944546005640 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 944546005641 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 944546005642 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 944546005643 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 944546005644 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 944546005645 RNA binding site [nucleotide binding]; other site 944546005646 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 944546005647 homotrimer interaction site [polypeptide binding]; other site 944546005648 putative active site [active] 944546005649 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 944546005650 nudix motif; other site 944546005651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944546005652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546005653 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 944546005654 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 944546005655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546005656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546005657 homodimer interface [polypeptide binding]; other site 944546005658 catalytic residue [active] 944546005659 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 944546005660 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 944546005661 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 944546005662 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 944546005663 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 944546005664 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 944546005665 THF binding site; other site 944546005666 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 944546005667 substrate binding site [chemical binding]; other site 944546005668 THF binding site; other site 944546005669 zinc-binding site [ion binding]; other site 944546005670 threonine dehydratase; Provisional; Region: PRK08526 944546005671 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 944546005672 tetramer interface [polypeptide binding]; other site 944546005673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546005674 catalytic residue [active] 944546005675 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 944546005676 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 944546005677 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 944546005678 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 944546005679 thiamine phosphate binding site [chemical binding]; other site 944546005680 active site 944546005681 pyrophosphate binding site [ion binding]; other site 944546005682 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 944546005683 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 944546005684 Dihydroneopterin aldolase; Region: FolB; pfam02152 944546005685 active site 944546005686 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 944546005687 quinolinate synthetase; Provisional; Region: PRK09375 944546005688 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 944546005689 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 944546005690 dimerization interface [polypeptide binding]; other site 944546005691 active site 944546005692 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 944546005693 DHH family; Region: DHH; pfam01368 944546005694 DHHA1 domain; Region: DHHA1; pfam02272 944546005695 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 944546005696 Peptidase family M23; Region: Peptidase_M23; pfam01551 944546005697 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 944546005698 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 944546005699 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 944546005700 homoserine kinase; Provisional; Region: PRK01212 944546005701 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 944546005702 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 944546005703 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 944546005704 translation initiation factor IF-2; Region: IF-2; TIGR00487 944546005705 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 944546005706 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 944546005707 G1 box; other site 944546005708 putative GEF interaction site [polypeptide binding]; other site 944546005709 GTP/Mg2+ binding site [chemical binding]; other site 944546005710 Switch I region; other site 944546005711 G2 box; other site 944546005712 G3 box; other site 944546005713 Switch II region; other site 944546005714 G4 box; other site 944546005715 G5 box; other site 944546005716 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 944546005717 Translation-initiation factor 2; Region: IF-2; pfam11987 944546005718 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 944546005719 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 944546005720 ribosome maturation protein RimP; Reviewed; Region: PRK00092 944546005721 Sm and related proteins; Region: Sm_like; cl00259 944546005722 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 944546005723 putative oligomer interface [polypeptide binding]; other site 944546005724 putative RNA binding site [nucleotide binding]; other site 944546005725 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 944546005726 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 944546005727 catalytic motif [active] 944546005728 Zn binding site [ion binding]; other site 944546005729 RibD C-terminal domain; Region: RibD_C; cl17279 944546005730 elongation factor P; Validated; Region: PRK00529 944546005731 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 944546005732 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 944546005733 RNA binding site [nucleotide binding]; other site 944546005734 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 944546005735 RNA binding site [nucleotide binding]; other site 944546005736 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 944546005737 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 944546005738 ligand binding site [chemical binding]; other site 944546005739 NAD binding site [chemical binding]; other site 944546005740 dimerization interface [polypeptide binding]; other site 944546005741 catalytic site [active] 944546005742 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 944546005743 putative L-serine binding site [chemical binding]; other site 944546005744 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 944546005745 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 944546005746 RNA binding site [nucleotide binding]; other site 944546005747 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 944546005748 RNA binding site [nucleotide binding]; other site 944546005749 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944546005750 RNA binding site [nucleotide binding]; other site 944546005751 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944546005752 RNA binding site [nucleotide binding]; other site 944546005753 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 944546005754 RNA binding site [nucleotide binding]; other site 944546005755 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 944546005756 RNA binding site [nucleotide binding]; other site 944546005757 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 944546005758 LytB protein; Region: LYTB; pfam02401 944546005759 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 944546005760 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 944546005761 hinge; other site 944546005762 active site 944546005763 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 944546005764 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 944546005765 putative tRNA-binding site [nucleotide binding]; other site 944546005766 tRNA synthetase B5 domain; Region: B5; smart00874 944546005767 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 944546005768 dimer interface [polypeptide binding]; other site 944546005769 motif 1; other site 944546005770 motif 3; other site 944546005771 motif 2; other site 944546005772 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 944546005773 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 944546005774 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 944546005775 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 944546005776 dimer interface [polypeptide binding]; other site 944546005777 motif 1; other site 944546005778 active site 944546005779 motif 2; other site 944546005780 motif 3; other site 944546005781 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 944546005782 nucleotide binding site/active site [active] 944546005783 HIT family signature motif; other site 944546005784 catalytic residue [active] 944546005785 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 944546005786 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 944546005787 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 944546005788 dimer interface [polypeptide binding]; other site 944546005789 active site 944546005790 acyl carrier protein; Provisional; Region: acpP; PRK00982 944546005791 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 944546005792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546005793 NAD(P) binding site [chemical binding]; other site 944546005794 active site 944546005795 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 944546005796 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 944546005797 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 944546005798 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 944546005799 Ligand Binding Site [chemical binding]; other site 944546005800 RNA methyltransferase, RsmE family; Region: TIGR00046 944546005801 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 944546005802 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 944546005803 Cytochrome c; Region: Cytochrom_C; pfam00034 944546005804 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 944546005805 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 944546005806 intrachain domain interface; other site 944546005807 interchain domain interface [polypeptide binding]; other site 944546005808 heme bH binding site [chemical binding]; other site 944546005809 Qi binding site; other site 944546005810 heme bL binding site [chemical binding]; other site 944546005811 Qo binding site; other site 944546005812 interchain domain interface [polypeptide binding]; other site 944546005813 intrachain domain interface; other site 944546005814 Qi binding site; other site 944546005815 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 944546005816 Qo binding site; other site 944546005817 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 944546005818 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 944546005819 iron-sulfur cluster [ion binding]; other site 944546005820 [2Fe-2S] cluster binding site [ion binding]; other site 944546005821 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 944546005822 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 944546005823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546005824 catalytic residue [active] 944546005825 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 944546005826 feedback inhibition sensing region; other site 944546005827 homohexameric interface [polypeptide binding]; other site 944546005828 nucleotide binding site [chemical binding]; other site 944546005829 N-acetyl-L-glutamate binding site [chemical binding]; other site 944546005830 putative recombination protein RecB; Provisional; Region: PRK13909 944546005831 Part of AAA domain; Region: AAA_19; pfam13245 944546005832 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 944546005833 Cytochrome c; Region: Cytochrom_C; cl11414 944546005834 peptide chain release factor 2; Validated; Region: prfB; PRK00578 944546005835 This domain is found in peptide chain release factors; Region: PCRF; smart00937 944546005836 RF-1 domain; Region: RF-1; pfam00472 944546005837 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 944546005838 dimer interface [polypeptide binding]; other site 944546005839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 944546005840 metal binding site [ion binding]; metal-binding site 944546005841 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 944546005842 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 944546005843 FixH; Region: FixH; pfam05751 944546005844 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 944546005845 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 944546005846 Cytochrome c; Region: Cytochrom_C; pfam00034 944546005847 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 944546005848 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 944546005849 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 944546005850 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 944546005851 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 944546005852 Low-spin heme binding site [chemical binding]; other site 944546005853 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 944546005854 D-pathway; other site 944546005855 Putative water exit pathway; other site 944546005856 Binuclear center (active site) [active] 944546005857 K-pathway; other site 944546005858 Putative proton exit pathway; other site 944546005859 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 944546005860 SmpB-tmRNA interface; other site 944546005861 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 944546005862 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 944546005863 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 944546005864 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 944546005865 active site 944546005866 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 944546005867 Part of AAA domain; Region: AAA_19; pfam13245 944546005868 Family description; Region: UvrD_C_2; pfam13538 944546005869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 944546005870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 944546005871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 944546005872 dimerization interface [polypeptide binding]; other site 944546005873 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 944546005874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546005875 amidophosphoribosyltransferase; Provisional; Region: PRK08525 944546005876 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 944546005877 active site 944546005878 tetramer interface [polypeptide binding]; other site 944546005879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546005880 active site 944546005881 dihydrodipicolinate reductase; Provisional; Region: PRK00048 944546005882 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 944546005883 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 944546005884 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 944546005885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 944546005886 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 944546005887 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 944546005888 catalytic residues [active] 944546005889 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 944546005890 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 944546005891 motif 1; other site 944546005892 active site 944546005893 motif 2; other site 944546005894 motif 3; other site 944546005895 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 944546005896 DHHA1 domain; Region: DHHA1; pfam02272 944546005897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 944546005898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546005899 putative substrate translocation pore; other site 944546005900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546005901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546005902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 944546005903 dimer interface [polypeptide binding]; other site 944546005904 phosphorylation site [posttranslational modification] 944546005905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546005906 ATP binding site [chemical binding]; other site 944546005907 Mg2+ binding site [ion binding]; other site 944546005908 G-X-G motif; other site 944546005909 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546005910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546005911 active site 944546005912 phosphorylation site [posttranslational modification] 944546005913 intermolecular recognition site; other site 944546005914 dimerization interface [polypeptide binding]; other site 944546005915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546005916 DNA binding site [nucleotide binding] 944546005917 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 944546005918 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 944546005919 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 944546005920 protein binding site [polypeptide binding]; other site 944546005921 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 944546005922 protein binding site [polypeptide binding]; other site 944546005923 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 944546005924 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 944546005925 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 944546005926 Walker A/P-loop; other site 944546005927 ATP binding site [chemical binding]; other site 944546005928 Q-loop/lid; other site 944546005929 ABC transporter signature motif; other site 944546005930 Walker B; other site 944546005931 D-loop; other site 944546005932 H-loop/switch region; other site 944546005933 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 944546005934 FtsX-like permease family; Region: FtsX; pfam02687 944546005935 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 944546005936 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 944546005937 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 944546005938 active site 944546005939 PQQ-like domain; Region: PQQ_2; pfam13360 944546005940 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 944546005941 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 944546005942 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 944546005943 protein binding site [polypeptide binding]; other site 944546005944 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 944546005945 Catalytic dyad [active] 944546005946 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 944546005947 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 944546005948 ATP binding site [chemical binding]; other site 944546005949 active site 944546005950 substrate binding site [chemical binding]; other site 944546005951 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 944546005952 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 944546005953 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 944546005954 putative active site [active] 944546005955 catalytic triad [active] 944546005956 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 944546005957 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 944546005958 putative acyl-acceptor binding pocket; other site 944546005959 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 944546005960 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 944546005961 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 944546005962 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 944546005963 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 944546005964 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 944546005965 active site 944546005966 HIGH motif; other site 944546005967 KMSK motif region; other site 944546005968 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 944546005969 tRNA binding surface [nucleotide binding]; other site 944546005970 anticodon binding site; other site 944546005971 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 944546005972 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 944546005973 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 944546005974 active site 944546005975 (T/H)XGH motif; other site 944546005976 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 944546005977 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 944546005978 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 944546005979 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 944546005980 Phosphoglycerate kinase; Region: PGK; pfam00162 944546005981 substrate binding site [chemical binding]; other site 944546005982 hinge regions; other site 944546005983 ADP binding site [chemical binding]; other site 944546005984 catalytic site [active] 944546005985 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 944546005986 triosephosphate isomerase; Provisional; Region: PRK14565 944546005987 substrate binding site [chemical binding]; other site 944546005988 dimer interface [polypeptide binding]; other site 944546005989 catalytic triad [active] 944546005990 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 944546005991 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 944546005992 NAD binding site [chemical binding]; other site 944546005993 homotetramer interface [polypeptide binding]; other site 944546005994 homodimer interface [polypeptide binding]; other site 944546005995 substrate binding site [chemical binding]; other site 944546005996 active site 944546005997 diaminopimelate decarboxylase; Region: lysA; TIGR01048 944546005998 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 944546005999 active site 944546006000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 944546006001 substrate binding site [chemical binding]; other site 944546006002 catalytic residues [active] 944546006003 dimer interface [polypeptide binding]; other site 944546006004 Chorismate mutase type II; Region: CM_2; cl00693 944546006005 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 944546006006 Prephenate dehydratase; Region: PDT; pfam00800 944546006007 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 944546006008 putative L-Phe binding site [chemical binding]; other site 944546006009 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 944546006010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 944546006011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006012 homodimer interface [polypeptide binding]; other site 944546006013 catalytic residue [active] 944546006014 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 944546006015 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 944546006016 TPP-binding site; other site 944546006017 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 944546006018 PYR/PP interface [polypeptide binding]; other site 944546006019 dimer interface [polypeptide binding]; other site 944546006020 TPP binding site [chemical binding]; other site 944546006021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 944546006022 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 944546006023 Maf-like protein; Reviewed; Region: PRK04056 944546006024 Maf-like protein; Region: Maf; pfam02545 944546006025 putative active site [active] 944546006026 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 944546006027 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 944546006028 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 944546006029 NlpC/P60 family; Region: NLPC_P60; pfam00877 944546006030 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 944546006031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 944546006032 ligand binding site [chemical binding]; other site 944546006033 flexible hinge region; other site 944546006034 putative switch regulator; other site 944546006035 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 944546006036 non-specific DNA interactions [nucleotide binding]; other site 944546006037 DNA binding site [nucleotide binding] 944546006038 sequence specific DNA binding site [nucleotide binding]; other site 944546006039 putative cAMP binding site [chemical binding]; other site 944546006040 hypothetical protein; Provisional; Region: PRK10410 944546006041 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 944546006042 ligand binding site [chemical binding]; other site 944546006043 active site 944546006044 UGI interface [polypeptide binding]; other site 944546006045 catalytic site [active] 944546006046 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 944546006047 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 944546006048 NAD(P) binding site [chemical binding]; other site 944546006049 catalytic residues [active] 944546006050 acetolactate synthase; Reviewed; Region: PRK08322 944546006051 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 944546006052 PYR/PP interface [polypeptide binding]; other site 944546006053 dimer interface [polypeptide binding]; other site 944546006054 TPP binding site [chemical binding]; other site 944546006055 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 944546006056 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 944546006057 TPP-binding site [chemical binding]; other site 944546006058 dimer interface [polypeptide binding]; other site 944546006059 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 944546006060 Repair protein; Region: Repair_PSII; cl01535 944546006061 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 944546006062 Repair protein; Region: Repair_PSII; pfam04536 944546006063 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 944546006064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 944546006065 motif II; other site 944546006066 Ferritin-like domain; Region: Ferritin; pfam00210 944546006067 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 944546006068 dimerization interface [polypeptide binding]; other site 944546006069 DPS ferroxidase diiron center [ion binding]; other site 944546006070 ion pore; other site 944546006071 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 944546006072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546006073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 944546006074 putative substrate translocation pore; other site 944546006075 HAMP domain; Region: HAMP; pfam00672 944546006076 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546006077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546006078 metal binding site [ion binding]; metal-binding site 944546006079 active site 944546006080 I-site; other site 944546006081 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944546006082 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546006083 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546006084 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 944546006085 Protein export membrane protein; Region: SecD_SecF; cl14618 944546006086 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 944546006087 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 944546006088 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546006089 N-terminal plug; other site 944546006090 ligand-binding site [chemical binding]; other site 944546006091 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546006092 FecR protein; Region: FecR; pfam04773 944546006093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 944546006094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546006095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546006096 DNA binding residues [nucleotide binding] 944546006097 flavoprotein, HI0933 family; Region: TIGR00275 944546006098 Cupin domain; Region: Cupin_2; pfam07883 944546006099 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 944546006100 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 944546006101 homodimer interface [polypeptide binding]; other site 944546006102 substrate-cofactor binding pocket; other site 944546006103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006104 catalytic residue [active] 944546006105 Transcriptional regulator; Region: Rrf2; pfam02082 944546006106 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 944546006107 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 944546006108 dimer interface [polypeptide binding]; other site 944546006109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006110 catalytic residue [active] 944546006111 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 944546006112 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 944546006113 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 944546006114 Active Sites [active] 944546006115 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 944546006116 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 944546006117 Active Sites [active] 944546006118 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 944546006119 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 944546006120 CysD dimerization site [polypeptide binding]; other site 944546006121 G1 box; other site 944546006122 putative GEF interaction site [polypeptide binding]; other site 944546006123 GTP/Mg2+ binding site [chemical binding]; other site 944546006124 Switch I region; other site 944546006125 G2 box; other site 944546006126 G3 box; other site 944546006127 Switch II region; other site 944546006128 G4 box; other site 944546006129 G5 box; other site 944546006130 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 944546006131 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 944546006132 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 944546006133 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 944546006134 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 944546006135 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 944546006136 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 944546006137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 944546006138 catalytic residue [active] 944546006139 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 944546006140 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 944546006141 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 944546006142 metal ion-dependent adhesion site (MIDAS); other site 944546006143 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944546006144 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 944546006145 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 944546006146 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 944546006147 active site 944546006148 catalytic triad [active] 944546006149 oxyanion hole [active] 944546006150 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 944546006151 putative dimer interface [polypeptide binding]; other site 944546006152 active site pocket [active] 944546006153 putative cataytic base [active] 944546006154 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 944546006155 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 944546006156 transmembrane helices; other site 944546006157 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 944546006158 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 944546006159 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 944546006160 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 944546006161 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 944546006162 DsbD alpha interface [polypeptide binding]; other site 944546006163 catalytic residues [active] 944546006164 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 944546006165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 944546006166 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 944546006167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546006168 metal binding site [ion binding]; metal-binding site 944546006169 active site 944546006170 I-site; other site 944546006171 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546006172 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 944546006173 MltA specific insert domain; Region: MltA; smart00925 944546006174 3D domain; Region: 3D; pfam06725 944546006175 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 944546006176 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 944546006177 nucleotide binding site [chemical binding]; other site 944546006178 NEF interaction site [polypeptide binding]; other site 944546006179 SBD interface [polypeptide binding]; other site 944546006180 GrpE; Region: GrpE; pfam01025 944546006181 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 944546006182 dimer interface [polypeptide binding]; other site 944546006183 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 944546006184 heat-inducible transcription repressor; Provisional; Region: PRK03911 944546006185 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 944546006186 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 944546006187 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 944546006188 dimerization interface 3.5A [polypeptide binding]; other site 944546006189 active site 944546006190 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 944546006191 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 944546006192 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 944546006193 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 944546006194 catalytic residue [active] 944546006195 putative FPP diphosphate binding site; other site 944546006196 putative FPP binding hydrophobic cleft; other site 944546006197 dimer interface [polypeptide binding]; other site 944546006198 putative IPP diphosphate binding site; other site 944546006199 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 944546006200 Flavoprotein; Region: Flavoprotein; pfam02441 944546006201 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 944546006202 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 944546006203 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 944546006204 Substrate binding site; other site 944546006205 Mg++ binding site; other site 944546006206 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 944546006207 active site 944546006208 substrate binding site [chemical binding]; other site 944546006209 CoA binding site [chemical binding]; other site 944546006210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006211 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546006212 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006213 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546006214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006215 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006216 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546006217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006218 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546006219 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 944546006220 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 944546006221 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 944546006222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 944546006223 nucleotide binding region [chemical binding]; other site 944546006224 ATP-binding site [chemical binding]; other site 944546006225 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 944546006226 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 944546006227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546006228 S-adenosylmethionine binding site [chemical binding]; other site 944546006229 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 944546006230 nudix motif; other site 944546006231 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 944546006232 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 944546006233 ATP binding site [chemical binding]; other site 944546006234 substrate binding site [chemical binding]; other site 944546006235 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 944546006236 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 944546006237 Ligand Binding Site [chemical binding]; other site 944546006238 FMN binding site [chemical binding]; other site 944546006239 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 944546006240 dimer interface [polypeptide binding]; other site 944546006241 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 944546006242 helix-hairpin-helix signature motif; other site 944546006243 active site 944546006244 Protein of unknown function DUF262; Region: DUF262; pfam03235 944546006245 Uncharacterized conserved protein [Function unknown]; Region: COG1479 944546006246 Protein of unknown function DUF262; Region: DUF262; pfam03235 944546006247 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 944546006248 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 944546006249 Integrase core domain; Region: rve; pfam00665 944546006250 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 944546006251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546006252 AAA domain; Region: AAA_22; pfam13401 944546006253 Walker A motif; other site 944546006254 ATP binding site [chemical binding]; other site 944546006255 Walker B motif; other site 944546006256 TniQ; Region: TniQ; pfam06527 944546006257 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 944546006258 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944546006259 active site 944546006260 DNA binding site [nucleotide binding] 944546006261 Int/Topo IB signature motif; other site 944546006262 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 944546006263 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 944546006264 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 944546006265 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 944546006266 Lumazine binding domain; Region: Lum_binding; pfam00677 944546006267 Lumazine binding domain; Region: Lum_binding; pfam00677 944546006268 rod shape-determining protein MreC; Provisional; Region: PRK13922 944546006269 rod shape-determining protein MreC; Region: MreC; pfam04085 944546006270 rod shape-determining protein MreB; Provisional; Region: PRK13927 944546006271 MreB and similar proteins; Region: MreB_like; cd10225 944546006272 nucleotide binding site [chemical binding]; other site 944546006273 Mg binding site [ion binding]; other site 944546006274 putative protofilament interaction site [polypeptide binding]; other site 944546006275 RodZ interaction site [polypeptide binding]; other site 944546006276 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 944546006277 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 944546006278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 944546006279 Walker A motif; other site 944546006280 ATP binding site [chemical binding]; other site 944546006281 Walker B motif; other site 944546006282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 944546006283 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 944546006284 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 944546006285 active site 944546006286 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 944546006287 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 944546006288 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 944546006289 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 944546006290 Ligand Binding Site [chemical binding]; other site 944546006291 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 944546006292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 944546006293 endonuclease IV; Provisional; Region: PRK01060 944546006294 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 944546006295 AP (apurinic/apyrimidinic) site pocket; other site 944546006296 DNA interaction; other site 944546006297 Metal-binding active site; metal-binding site 944546006298 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 944546006299 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 944546006300 Protein export membrane protein; Region: SecD_SecF; cl14618 944546006301 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 944546006302 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 944546006303 HlyD family secretion protein; Region: HlyD_3; pfam13437 944546006304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 944546006305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 944546006306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 944546006307 putative substrate translocation pore; other site 944546006308 putative transporter; Provisional; Region: PRK11660 944546006309 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 944546006310 Sulfate transporter family; Region: Sulfate_transp; pfam00916 944546006311 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 944546006312 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944546006313 Sel1 repeat; Region: Sel1; cl02723 944546006314 Sel1-like repeats; Region: SEL1; smart00671 944546006315 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 944546006316 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 944546006317 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 944546006318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 944546006319 active site 944546006320 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 944546006321 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 944546006322 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 944546006323 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 944546006324 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 944546006325 active site 944546006326 interdomain interaction site; other site 944546006327 putative metal-binding site [ion binding]; other site 944546006328 nucleotide binding site [chemical binding]; other site 944546006329 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 944546006330 domain I; other site 944546006331 DNA binding groove [nucleotide binding] 944546006332 phosphate binding site [ion binding]; other site 944546006333 domain II; other site 944546006334 domain III; other site 944546006335 nucleotide binding site [chemical binding]; other site 944546006336 catalytic site [active] 944546006337 domain IV; other site 944546006338 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 944546006339 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 944546006340 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 944546006341 active site 944546006342 metal binding site [ion binding]; metal-binding site 944546006343 homotetramer interface [polypeptide binding]; other site 944546006344 biotin synthase; Provisional; Region: PRK08508 944546006345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 944546006346 FeS/SAM binding site; other site 944546006347 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 944546006348 AMIN domain; Region: AMIN; pfam11741 944546006349 enolase; Provisional; Region: eno; PRK00077 944546006350 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 944546006351 dimer interface [polypeptide binding]; other site 944546006352 metal binding site [ion binding]; metal-binding site 944546006353 substrate binding pocket [chemical binding]; other site 944546006354 recombinase A; Provisional; Region: recA; PRK09354 944546006355 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 944546006356 hexamer interface [polypeptide binding]; other site 944546006357 Walker A motif; other site 944546006358 ATP binding site [chemical binding]; other site 944546006359 Walker B motif; other site 944546006360 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 944546006361 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 944546006362 NAD(P) binding site [chemical binding]; other site 944546006363 homodimer interface [polypeptide binding]; other site 944546006364 substrate binding site [chemical binding]; other site 944546006365 active site 944546006366 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 944546006367 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 944546006368 inhibitor-cofactor binding pocket; inhibition site 944546006369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006370 catalytic residue [active] 944546006371 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 944546006372 ligand binding site; other site 944546006373 tetramer interface; other site 944546006374 pseudaminic acid synthase; Region: PseI; TIGR03586 944546006375 NeuB family; Region: NeuB; pfam03102 944546006376 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 944546006377 NeuB binding interface [polypeptide binding]; other site 944546006378 putative substrate binding site [chemical binding]; other site 944546006379 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 944546006380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 944546006381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546006382 S-adenosylmethionine binding site [chemical binding]; other site 944546006383 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 944546006384 LicD family; Region: LicD; pfam04991 944546006385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546006386 S-adenosylmethionine binding site [chemical binding]; other site 944546006387 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 944546006388 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 944546006389 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 944546006390 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944546006391 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 944546006392 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 944546006393 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 944546006394 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 944546006395 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 944546006396 4Fe-4S binding domain; Region: Fer4_5; pfam12801 944546006397 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 944546006398 CTP synthetase; Validated; Region: pyrG; PRK05380 944546006399 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 944546006400 Catalytic site [active] 944546006401 active site 944546006402 UTP binding site [chemical binding]; other site 944546006403 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 944546006404 active site 944546006405 putative oxyanion hole; other site 944546006406 catalytic triad [active] 944546006407 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 944546006408 DHH family; Region: DHH; pfam01368 944546006409 DHHA1 domain; Region: DHHA1; pfam02272 944546006410 Predicted integral membrane protein [Function unknown]; Region: COG5616 944546006411 DJ-1 family protein; Region: not_thiJ; TIGR01383 944546006412 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 944546006413 conserved cys residue [active] 944546006414 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 944546006415 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 944546006416 active site 944546006417 PHP Thumb interface [polypeptide binding]; other site 944546006418 metal binding site [ion binding]; metal-binding site 944546006419 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 944546006420 generic binding surface II; other site 944546006421 generic binding surface I; other site 944546006422 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 944546006423 Protein of unknown function (DUF493); Region: DUF493; pfam04359 944546006424 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 944546006425 trimer interface [polypeptide binding]; other site 944546006426 dimer interface [polypeptide binding]; other site 944546006427 putative active site [active] 944546006428 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 944546006429 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 944546006430 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 944546006431 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 944546006432 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 944546006433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546006434 S-adenosylmethionine binding site [chemical binding]; other site 944546006435 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 944546006436 ribosome recycling factor; Reviewed; Region: frr; PRK00083 944546006437 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 944546006438 hinge region; other site 944546006439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 944546006440 active site 944546006441 RDD family; Region: RDD; pfam06271 944546006442 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 944546006443 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 944546006444 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 944546006445 Cl binding site [ion binding]; other site 944546006446 oligomer interface [polypeptide binding]; other site 944546006447 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 944546006448 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 944546006449 catalytic residues [active] 944546006450 catalytic nucleophile [active] 944546006451 Presynaptic Site I dimer interface [polypeptide binding]; other site 944546006452 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 944546006453 Synaptic Flat tetramer interface [polypeptide binding]; other site 944546006454 Synaptic Site I dimer interface [polypeptide binding]; other site 944546006455 DNA binding site [nucleotide binding] 944546006456 Protein of unknown function (DUF328); Region: DUF328; pfam03883 944546006457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 944546006458 active site 944546006459 Int/Topo IB signature motif; other site 944546006460 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 944546006461 active site 944546006462 catalytic residues [active] 944546006463 DNA binding site [nucleotide binding] 944546006464 Int/Topo IB signature motif; other site 944546006465 Protein of unknown function (DUF328); Region: DUF328; cl01143 944546006466 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 944546006467 Helix-hairpin-helix motif; Region: HHH; pfam00633 944546006468 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 944546006469 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 944546006470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 944546006471 putative active site [active] 944546006472 putative metal binding site [ion binding]; other site 944546006473 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 944546006474 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 944546006475 putative dimer interface [polypeptide binding]; other site 944546006476 Hemerythrin; Region: Hemerythrin; cd12107 944546006477 Fe binding site [ion binding]; other site 944546006478 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 944546006479 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 944546006480 dimer interface [polypeptide binding]; other site 944546006481 putative CheW interface [polypeptide binding]; other site 944546006482 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 944546006483 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 944546006484 ATP binding site [chemical binding]; other site 944546006485 substrate interface [chemical binding]; other site 944546006486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 944546006487 active site residue [active] 944546006488 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944546006489 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 944546006490 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944546006491 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 944546006492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 944546006493 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 944546006494 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 944546006495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 944546006496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 944546006497 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 944546006498 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 944546006499 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 944546006500 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 944546006501 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 944546006502 Walker A/P-loop; other site 944546006503 ATP binding site [chemical binding]; other site 944546006504 Q-loop/lid; other site 944546006505 ABC transporter signature motif; other site 944546006506 Walker B; other site 944546006507 D-loop; other site 944546006508 H-loop/switch region; other site 944546006509 TOBE-like domain; Region: TOBE_3; pfam12857 944546006510 sulfate transport protein; Provisional; Region: cysT; CHL00187 944546006511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546006512 dimer interface [polypeptide binding]; other site 944546006513 conserved gate region; other site 944546006514 putative PBP binding loops; other site 944546006515 ABC-ATPase subunit interface; other site 944546006516 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 944546006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546006518 dimer interface [polypeptide binding]; other site 944546006519 conserved gate region; other site 944546006520 putative PBP binding loops; other site 944546006521 ABC-ATPase subunit interface; other site 944546006522 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 944546006523 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 944546006524 dimer interface [polypeptide binding]; other site 944546006525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006526 catalytic residue [active] 944546006527 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546006528 metal binding site [ion binding]; metal-binding site 944546006529 active site 944546006530 I-site; other site 944546006531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 944546006532 Ubiquitin-like proteins; Region: UBQ; cl00155 944546006533 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 944546006534 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 944546006535 threonine synthase; Validated; Region: PRK08197 944546006536 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 944546006537 homodimer interface [polypeptide binding]; other site 944546006538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 944546006539 catalytic residue [active] 944546006540 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 944546006541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546006542 dimer interface [polypeptide binding]; other site 944546006543 conserved gate region; other site 944546006544 putative PBP binding loops; other site 944546006545 ABC-ATPase subunit interface; other site 944546006546 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 944546006547 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 944546006548 Walker A/P-loop; other site 944546006549 ATP binding site [chemical binding]; other site 944546006550 Q-loop/lid; other site 944546006551 ABC transporter signature motif; other site 944546006552 Walker B; other site 944546006553 D-loop; other site 944546006554 H-loop/switch region; other site 944546006555 NMT1-like family; Region: NMT1_2; pfam13379 944546006556 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 944546006557 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 944546006558 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 944546006559 active site 944546006560 dimer interface [polypeptide binding]; other site 944546006561 non-prolyl cis peptide bond; other site 944546006562 insertion regions; other site 944546006563 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 944546006564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546006565 substrate binding pocket [chemical binding]; other site 944546006566 membrane-bound complex binding site; other site 944546006567 Amidohydrolase; Region: Amidohydro_2; pfam04909 944546006568 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 944546006569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 944546006570 Walker A/P-loop; other site 944546006571 ATP binding site [chemical binding]; other site 944546006572 Q-loop/lid; other site 944546006573 ABC transporter signature motif; other site 944546006574 Walker B; other site 944546006575 D-loop; other site 944546006576 H-loop/switch region; other site 944546006577 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 944546006578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 944546006579 putative PBP binding loops; other site 944546006580 dimer interface [polypeptide binding]; other site 944546006581 ABC-ATPase subunit interface; other site 944546006582 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 944546006583 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 944546006584 active site 944546006585 dimer interface [polypeptide binding]; other site 944546006586 non-prolyl cis peptide bond; other site 944546006587 insertion regions; other site 944546006588 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 944546006589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 944546006590 substrate binding pocket [chemical binding]; other site 944546006591 membrane-bound complex binding site; other site 944546006592 hinge residues; other site 944546006593 Rrf2 family protein; Region: rrf2_super; TIGR00738 944546006594 Transcriptional regulator; Region: Rrf2; pfam02082 944546006595 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 944546006596 active site 944546006597 Zn binding site [ion binding]; other site 944546006598 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 944546006599 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 944546006600 putative active site [active] 944546006601 Zn binding site [ion binding]; other site 944546006602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 944546006603 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 944546006604 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 944546006605 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 944546006606 G1 box; other site 944546006607 putative GEF interaction site [polypeptide binding]; other site 944546006608 GTP/Mg2+ binding site [chemical binding]; other site 944546006609 Switch I region; other site 944546006610 G2 box; other site 944546006611 G3 box; other site 944546006612 Switch II region; other site 944546006613 G4 box; other site 944546006614 G5 box; other site 944546006615 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 944546006616 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 944546006617 putative inner membrane protein; Provisional; Region: PRK11099 944546006618 hypothetical protein; Provisional; Region: PRK11018 944546006619 CPxP motif; other site 944546006620 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 944546006621 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 944546006622 Secretin and TonB N terminus short domain; Region: STN; smart00965 944546006623 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 944546006624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 944546006625 N-terminal plug; other site 944546006626 ligand-binding site [chemical binding]; other site 944546006627 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 944546006628 FecR protein; Region: FecR; pfam04773 944546006629 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 944546006630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 944546006631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 944546006632 DNA binding residues [nucleotide binding] 944546006633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546006634 PAS fold; Region: PAS_3; pfam08447 944546006635 putative active site [active] 944546006636 heme pocket [chemical binding]; other site 944546006637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546006638 putative active site [active] 944546006639 PAS fold; Region: PAS_3; pfam08447 944546006640 heme pocket [chemical binding]; other site 944546006641 PAS domain; Region: PAS_9; pfam13426 944546006642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 944546006643 putative active site [active] 944546006644 heme pocket [chemical binding]; other site 944546006645 PAS domain S-box; Region: sensory_box; TIGR00229 944546006646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 944546006647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 944546006648 metal binding site [ion binding]; metal-binding site 944546006649 active site 944546006650 I-site; other site 944546006651 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 944546006652 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 944546006653 Sulfatase; Region: Sulfatase; pfam00884 944546006654 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 944546006655 active site 944546006656 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 944546006657 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 944546006658 Dihaem cytochrome c; Region: DHC; pfam09626 944546006659 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 944546006660 Dihaem cytochrome c; Region: DHC; pfam09626 944546006661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 944546006662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 944546006663 active site 944546006664 phosphorylation site [posttranslational modification] 944546006665 intermolecular recognition site; other site 944546006666 dimerization interface [polypeptide binding]; other site 944546006667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 944546006668 DNA binding site [nucleotide binding] 944546006669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 944546006670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 944546006671 dimerization interface [polypeptide binding]; other site 944546006672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 944546006673 ATP binding site [chemical binding]; other site 944546006674 Mg2+ binding site [ion binding]; other site 944546006675 G-X-G motif; other site 944546006676 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 944546006677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 944546006678 S-adenosylmethionine binding site [chemical binding]; other site 944546006679 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 944546006680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 944546006681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 944546006682 Zn2+ binding site [ion binding]; other site 944546006683 Mg2+ binding site [ion binding]; other site 944546006684 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 944546006685 Predicted membrane protein [Function unknown]; Region: COG2860 944546006686 UPF0126 domain; Region: UPF0126; pfam03458 944546006687 UPF0126 domain; Region: UPF0126; pfam03458 944546006688 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 944546006689 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 944546006690 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 944546006691 active site 944546006692 substrate binding site [chemical binding]; other site 944546006693 cosubstrate binding site; other site 944546006694 catalytic site [active] 944546006695 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 944546006696 active site 944546006697 putative DNA-binding cleft [nucleotide binding]; other site 944546006698 dimer interface [polypeptide binding]; other site