-- dump date 20140618_204910 -- class Genbank::misc_feature -- table misc_feature_note -- id note 367737000001 UNKNOWN FEATURE KEY Comment; Source DNA and bacteria available from William Miller (bmiller@pw.usda.gov) 367737000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 367737000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737000004 Walker A motif; other site 367737000005 ATP binding site [chemical binding]; other site 367737000006 Walker B motif; other site 367737000007 arginine finger; other site 367737000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 367737000009 DnaA box-binding interface [nucleotide binding]; other site 367737000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 367737000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 367737000012 putative DNA binding surface [nucleotide binding]; other site 367737000013 dimer interface [polypeptide binding]; other site 367737000014 beta-clamp/clamp loader binding surface; other site 367737000015 beta-clamp/translesion DNA polymerase binding surface; other site 367737000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 367737000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737000018 Mg2+ binding site [ion binding]; other site 367737000019 G-X-G motif; other site 367737000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 367737000021 anchoring element; other site 367737000022 dimer interface [polypeptide binding]; other site 367737000023 ATP binding site [chemical binding]; other site 367737000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 367737000025 active site 367737000026 putative metal-binding site [ion binding]; other site 367737000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 367737000028 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 367737000029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367737000030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367737000031 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 367737000032 Predicted membrane protein [Function unknown]; Region: COG1238 367737000033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737000034 S-adenosylmethionine binding site [chemical binding]; other site 367737000035 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367737000036 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 367737000037 Walker A/P-loop; other site 367737000038 ATP binding site [chemical binding]; other site 367737000039 Q-loop/lid; other site 367737000040 ABC transporter signature motif; other site 367737000041 Walker B; other site 367737000042 D-loop; other site 367737000043 H-loop/switch region; other site 367737000044 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 367737000045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737000046 dimer interface [polypeptide binding]; other site 367737000047 conserved gate region; other site 367737000048 putative PBP binding loops; other site 367737000049 ABC-ATPase subunit interface; other site 367737000050 TOBE domain; Region: TOBE; cl01440 367737000051 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 367737000052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 367737000053 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 367737000054 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 367737000055 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 367737000056 molybdenum-pterin binding domain; Region: Mop; TIGR00638 367737000057 Predicted membrane protein [Function unknown]; Region: COG3174 367737000058 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 367737000059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 367737000060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 367737000061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 367737000062 dimerization interface [polypeptide binding]; other site 367737000063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737000064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737000065 putative substrate translocation pore; other site 367737000066 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 367737000067 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 367737000068 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 367737000069 active site 367737000070 adenylosuccinate lyase; Provisional; Region: PRK08470 367737000071 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 367737000072 tetramer interface [polypeptide binding]; other site 367737000073 active site 367737000074 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 367737000075 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 367737000076 ATP cone domain; Region: ATP-cone; pfam03477 367737000077 Class I ribonucleotide reductase; Region: RNR_I; cd01679 367737000078 active site 367737000079 dimer interface [polypeptide binding]; other site 367737000080 catalytic residues [active] 367737000081 effector binding site; other site 367737000082 R2 peptide binding site; other site 367737000083 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 367737000084 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 367737000085 dimer interface [polypeptide binding]; other site 367737000086 putative radical transfer pathway; other site 367737000087 diiron center [ion binding]; other site 367737000088 tyrosyl radical; other site 367737000089 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 367737000090 active site 367737000091 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737000092 ligand binding site [chemical binding]; other site 367737000093 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737000094 Uncharacterized conserved protein [Function unknown]; Region: COG3743 367737000095 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 367737000096 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 367737000097 NADP binding site [chemical binding]; other site 367737000098 dimer interface [polypeptide binding]; other site 367737000099 Predicted transcriptional regulators [Transcription]; Region: COG1733 367737000100 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 367737000101 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 367737000102 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 367737000103 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 367737000104 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 367737000105 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 367737000106 GatB domain; Region: GatB_Yqey; smart00845 367737000107 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 367737000108 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 367737000109 FAD binding domain; Region: FAD_binding_4; pfam01565 367737000110 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 367737000111 L-lactate permease; Region: Lactate_perm; cl00701 367737000112 glycolate transporter; Provisional; Region: PRK09695 367737000113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737000114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000115 active site 367737000116 phosphorylation site [posttranslational modification] 367737000117 intermolecular recognition site; other site 367737000118 dimerization interface [polypeptide binding]; other site 367737000119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 367737000120 DNA binding site [nucleotide binding] 367737000121 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 367737000122 PAS fold; Region: PAS_4; pfam08448 367737000123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737000124 putative active site [active] 367737000125 heme pocket [chemical binding]; other site 367737000126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737000127 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 367737000128 ATP binding site [chemical binding]; other site 367737000129 G-X-G motif; other site 367737000130 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 367737000131 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 367737000132 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 367737000133 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 367737000134 Cysteine-rich domain; Region: CCG; pfam02754 367737000135 Cysteine-rich domain; Region: CCG; pfam02754 367737000136 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 367737000137 catalytic motif [active] 367737000138 Zn binding site [ion binding]; other site 367737000139 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 367737000140 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 367737000141 carboxyltransferase (CT) interaction site; other site 367737000142 biotinylation site [posttranslational modification]; other site 367737000143 biotin carboxylase; Validated; Region: PRK08462 367737000144 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367737000145 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367737000146 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 367737000147 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 367737000148 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 367737000149 ATP binding site [chemical binding]; other site 367737000150 Mg++ binding site [ion binding]; other site 367737000151 motif III; other site 367737000152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737000153 nucleotide binding region [chemical binding]; other site 367737000154 ATP-binding site [chemical binding]; other site 367737000155 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 367737000156 Phosphate transporter family; Region: PHO4; pfam01384 367737000157 Phosphate transporter family; Region: PHO4; cl00396 367737000158 Membrane transport protein; Region: Mem_trans; cl09117 367737000159 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 367737000160 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 367737000161 active site 367737000162 dimer interface [polypeptide binding]; other site 367737000163 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 367737000164 Ligand Binding Site [chemical binding]; other site 367737000165 Molecular Tunnel; other site 367737000166 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 367737000167 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 367737000168 putative active site [active] 367737000169 PhoH-like protein; Region: PhoH; pfam02562 367737000170 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 367737000171 recombination factor protein RarA; Reviewed; Region: PRK13342 367737000172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737000173 Walker A motif; other site 367737000174 ATP binding site [chemical binding]; other site 367737000175 Walker B motif; other site 367737000176 arginine finger; other site 367737000177 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 367737000178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737000179 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 367737000180 RNA binding surface [nucleotide binding]; other site 367737000181 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 367737000182 active site 367737000183 KpsF/GutQ family protein; Region: kpsF; TIGR00393 367737000184 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 367737000185 putative active site [active] 367737000186 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 367737000187 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 367737000188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 367737000189 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 367737000190 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 367737000191 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 367737000192 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 367737000193 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 367737000194 substrate binding site [chemical binding]; other site 367737000195 glutamase interaction surface [polypeptide binding]; other site 367737000196 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 367737000197 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 367737000198 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 367737000199 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 367737000200 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 367737000201 active site 367737000202 HIGH motif; other site 367737000203 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 367737000204 active site 367737000205 KMSKS motif; other site 367737000206 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 367737000207 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 367737000208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000209 active site 367737000210 phosphorylation site [posttranslational modification] 367737000211 intermolecular recognition site; other site 367737000212 dimerization interface [polypeptide binding]; other site 367737000213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737000214 DNA binding site [nucleotide binding] 367737000215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737000216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737000217 dimer interface [polypeptide binding]; other site 367737000218 phosphorylation site [posttranslational modification] 367737000219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737000220 ATP binding site [chemical binding]; other site 367737000221 Mg2+ binding site [ion binding]; other site 367737000222 G-X-G motif; other site 367737000223 YtkA-like; Region: YtkA; pfam13115 367737000224 Outer membrane efflux protein; Region: OEP; pfam02321 367737000225 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 367737000226 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737000227 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 367737000228 Uncharacterized conserved protein [Function unknown]; Region: COG2353 367737000229 Domain of unknown function (DUF814); Region: DUF814; pfam05670 367737000230 Adhesion protein FadA; Region: FadA; pfam09403 367737000231 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 367737000232 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 367737000233 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 367737000234 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 367737000235 active site 367737000236 dimer interface [polypeptide binding]; other site 367737000237 motif 1; other site 367737000238 motif 2; other site 367737000239 motif 3; other site 367737000240 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 367737000241 anticodon binding site; other site 367737000242 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 367737000243 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 367737000244 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 367737000245 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 367737000246 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 367737000247 23S rRNA binding site [nucleotide binding]; other site 367737000248 L21 binding site [polypeptide binding]; other site 367737000249 L13 binding site [polypeptide binding]; other site 367737000250 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737000251 active site residue [active] 367737000252 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737000253 active site residue [active] 367737000254 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737000255 active site residue [active] 367737000256 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 367737000257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367737000258 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 367737000259 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 367737000260 GTP binding site; other site 367737000261 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 367737000262 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 367737000263 substrate binding site [chemical binding]; other site 367737000264 ligand binding site [chemical binding]; other site 367737000265 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 367737000266 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 367737000267 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 367737000268 active site 367737000269 substrate binding site [chemical binding]; other site 367737000270 metal binding site [ion binding]; metal-binding site 367737000271 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 367737000272 peptide chain release factor 1; Validated; Region: prfA; PRK00591 367737000273 This domain is found in peptide chain release factors; Region: PCRF; smart00937 367737000274 RF-1 domain; Region: RF-1; pfam00472 367737000275 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 367737000276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737000277 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 367737000278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737000279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737000280 metal binding site [ion binding]; metal-binding site 367737000281 active site 367737000282 I-site; other site 367737000283 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 367737000284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737000285 dimer interface [polypeptide binding]; other site 367737000286 conserved gate region; other site 367737000287 putative PBP binding loops; other site 367737000288 ABC-ATPase subunit interface; other site 367737000289 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 367737000290 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 367737000291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737000292 dimer interface [polypeptide binding]; other site 367737000293 conserved gate region; other site 367737000294 putative PBP binding loops; other site 367737000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 367737000296 ABC-ATPase subunit interface; other site 367737000297 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 367737000298 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 367737000299 Walker A/P-loop; other site 367737000300 ATP binding site [chemical binding]; other site 367737000301 Q-loop/lid; other site 367737000302 ABC transporter signature motif; other site 367737000303 Walker B; other site 367737000304 D-loop; other site 367737000305 H-loop/switch region; other site 367737000306 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 367737000307 PhoU domain; Region: PhoU; pfam01895 367737000308 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737000309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000310 active site 367737000311 phosphorylation site [posttranslational modification] 367737000312 intermolecular recognition site; other site 367737000313 dimerization interface [polypeptide binding]; other site 367737000314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737000315 DNA binding site [nucleotide binding] 367737000316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737000317 dimer interface [polypeptide binding]; other site 367737000318 phosphorylation site [posttranslational modification] 367737000319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 367737000320 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 367737000321 23S rRNA interface [nucleotide binding]; other site 367737000322 L3 interface [polypeptide binding]; other site 367737000323 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 367737000324 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 367737000325 peptide binding site [polypeptide binding]; other site 367737000326 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 367737000327 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 367737000328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737000329 motif II; other site 367737000330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 367737000331 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 367737000332 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 367737000333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000335 active site 367737000336 phosphorylation site [posttranslational modification] 367737000337 intermolecular recognition site; other site 367737000338 dimerization interface [polypeptide binding]; other site 367737000339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737000340 DNA binding site [nucleotide binding] 367737000341 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737000342 PAS domain S-box; Region: sensory_box; TIGR00229 367737000343 PAS domain; Region: PAS; smart00091 367737000344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737000345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737000346 ATP binding site [chemical binding]; other site 367737000347 Mg2+ binding site [ion binding]; other site 367737000348 G-X-G motif; other site 367737000349 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 367737000350 active site clefts [active] 367737000351 zinc binding site [ion binding]; other site 367737000352 dimer interface [polypeptide binding]; other site 367737000353 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 367737000354 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 367737000355 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 367737000356 Protein of unknown function (DUF330); Region: DUF330; cl01135 367737000357 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 367737000358 mce related protein; Region: MCE; pfam02470 367737000359 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 367737000360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737000361 Walker A/P-loop; other site 367737000362 ATP binding site [chemical binding]; other site 367737000363 Q-loop/lid; other site 367737000364 ABC transporter signature motif; other site 367737000365 Walker B; other site 367737000366 D-loop; other site 367737000367 H-loop/switch region; other site 367737000368 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 367737000369 Permease; Region: Permease; pfam02405 367737000370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737000371 AAA ATPase domain; Region: AAA_15; pfam13175 367737000372 Walker A/P-loop; other site 367737000373 ATP binding site [chemical binding]; other site 367737000374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737000375 Q-loop/lid; other site 367737000376 ABC transporter signature motif; other site 367737000377 Walker B; other site 367737000378 D-loop; other site 367737000379 H-loop/switch region; other site 367737000380 S-ribosylhomocysteinase; Provisional; Region: PRK02260 367737000381 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 367737000382 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 367737000383 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 367737000384 Predicted membrane protein [Function unknown]; Region: COG2259 367737000385 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 367737000386 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 367737000387 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 367737000388 substrate binding pocket [chemical binding]; other site 367737000389 dimer interface [polypeptide binding]; other site 367737000390 inhibitor binding site; inhibition site 367737000391 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 367737000392 B12 binding site [chemical binding]; other site 367737000393 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 367737000394 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 367737000395 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 367737000396 homodimer interface [polypeptide binding]; other site 367737000397 substrate-cofactor binding pocket; other site 367737000398 catalytic residue [active] 367737000399 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 367737000400 SPFH domain / Band 7 family; Region: Band_7; pfam01145 367737000401 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 367737000402 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 367737000403 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 367737000404 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 367737000405 metal binding site [ion binding]; metal-binding site 367737000406 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367737000407 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 367737000408 ThiC family; Region: ThiC; pfam01964 367737000409 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 367737000410 HDOD domain; Region: HDOD; pfam08668 367737000411 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 367737000412 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 367737000413 substrate binding site; other site 367737000414 dimer interface; other site 367737000415 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 367737000416 homotrimer interaction site [polypeptide binding]; other site 367737000417 zinc binding site [ion binding]; other site 367737000418 CDP-binding sites; other site 367737000419 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 367737000420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000421 active site 367737000422 phosphorylation site [posttranslational modification] 367737000423 dimerization interface [polypeptide binding]; other site 367737000424 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 367737000425 tetramer interfaces [polypeptide binding]; other site 367737000426 binuclear metal-binding site [ion binding]; other site 367737000427 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 367737000428 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 367737000429 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 367737000430 catalytic site [active] 367737000431 subunit interface [polypeptide binding]; other site 367737000432 Protein of unknown function (DUF507); Region: DUF507; pfam04368 367737000433 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 367737000434 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 367737000435 GDP-binding site [chemical binding]; other site 367737000436 ACT binding site; other site 367737000437 IMP binding site; other site 367737000438 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12293 367737000439 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367737000440 motif 1; other site 367737000441 dimer interface [polypeptide binding]; other site 367737000442 active site 367737000443 motif 2; other site 367737000444 motif 3; other site 367737000445 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 367737000446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737000447 catalytic residue [active] 367737000448 Uncharacterized conserved protein [Function unknown]; Region: COG2353 367737000449 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 367737000450 MarR family; Region: MarR_2; cl17246 367737000451 Uncharacterized conserved protein [Function unknown]; Region: COG2353 367737000452 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 367737000453 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 367737000454 putative active site [active] 367737000455 metal binding site [ion binding]; metal-binding site 367737000456 Pirin-related protein [General function prediction only]; Region: COG1741 367737000457 Pirin; Region: Pirin; pfam02678 367737000458 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 367737000459 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 367737000460 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 367737000461 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 367737000462 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 367737000463 dimerization interface [polypeptide binding]; other site 367737000464 putative ATP binding site [chemical binding]; other site 367737000465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 367737000466 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 367737000467 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 367737000468 CoA-binding site [chemical binding]; other site 367737000469 ATP-binding [chemical binding]; other site 367737000470 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 367737000471 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 367737000472 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 367737000473 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 367737000474 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367737000475 ATP-grasp domain; Region: ATP-grasp; pfam02222 367737000476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367737000477 Coenzyme A binding pocket [chemical binding]; other site 367737000478 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 367737000479 Sel1-like repeats; Region: SEL1; smart00671 367737000480 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 367737000481 prenyltransferase; Reviewed; Region: ubiA; PRK12874 367737000482 UbiA prenyltransferase family; Region: UbiA; pfam01040 367737000483 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 367737000484 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 367737000485 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 367737000486 Predicted methyltransferases [General function prediction only]; Region: COG0313 367737000487 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 367737000488 putative SAM binding site [chemical binding]; other site 367737000489 putative homodimer interface [polypeptide binding]; other site 367737000490 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 367737000491 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 367737000492 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 367737000493 aspartate aminotransferase; Provisional; Region: PRK08636 367737000494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737000495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737000496 homodimer interface [polypeptide binding]; other site 367737000497 catalytic residue [active] 367737000498 homoserine dehydrogenase; Provisional; Region: PRK06349 367737000499 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 367737000500 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 367737000501 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 367737000502 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 367737000503 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 367737000504 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 367737000505 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 367737000506 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 367737000507 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 367737000508 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 367737000509 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 367737000510 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 367737000511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367737000512 UGMP family protein; Validated; Region: PRK09604 367737000513 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 367737000514 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 367737000515 putative rRNA binding site [nucleotide binding]; other site 367737000516 Uncharacterized conserved protein [Function unknown]; Region: COG0062 367737000517 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 367737000518 putative substrate binding site [chemical binding]; other site 367737000519 putative ATP binding site [chemical binding]; other site 367737000520 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 367737000521 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 367737000522 ThiS interaction site; other site 367737000523 putative active site [active] 367737000524 tetramer interface [polypeptide binding]; other site 367737000525 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 367737000526 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 367737000527 active site 367737000528 catalytic residues [active] 367737000529 metal binding site [ion binding]; metal-binding site 367737000530 homodimer binding site [polypeptide binding]; other site 367737000531 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 367737000532 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 367737000533 carboxyltransferase (CT) interaction site; other site 367737000534 biotinylation site [posttranslational modification]; other site 367737000535 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 367737000536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737000537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737000538 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 367737000539 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 367737000540 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 367737000541 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 367737000542 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 367737000543 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737000544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737000545 dimer interface [polypeptide binding]; other site 367737000546 putative CheW interface [polypeptide binding]; other site 367737000547 PLD-like domain; Region: PLDc_2; pfam13091 367737000548 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 367737000549 putative homodimer interface [polypeptide binding]; other site 367737000550 putative active site [active] 367737000551 catalytic site [active] 367737000552 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 367737000553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737000554 ATP binding site [chemical binding]; other site 367737000555 putative Mg++ binding site [ion binding]; other site 367737000556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737000557 nucleotide binding region [chemical binding]; other site 367737000558 ATP-binding site [chemical binding]; other site 367737000559 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 367737000560 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 367737000561 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 367737000562 TPP-binding site [chemical binding]; other site 367737000563 dimer interface [polypeptide binding]; other site 367737000564 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 367737000565 PYR/PP interface [polypeptide binding]; other site 367737000566 dimer interface [polypeptide binding]; other site 367737000567 TPP binding site [chemical binding]; other site 367737000568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 367737000569 LrgA family; Region: LrgA; pfam03788 367737000570 LrgB-like family; Region: LrgB; pfam04172 367737000571 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 367737000572 putative active site pocket [active] 367737000573 dimerization interface [polypeptide binding]; other site 367737000574 putative catalytic residue [active] 367737000575 Predicted membrane protein [Function unknown]; Region: COG3766 367737000576 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 367737000577 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 367737000578 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 367737000579 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 367737000580 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 367737000581 DNA binding residues [nucleotide binding] 367737000582 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 367737000583 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 367737000584 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 367737000585 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 367737000586 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 367737000587 putative acyl-acceptor binding pocket; other site 367737000588 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 367737000589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737000590 putative substrate translocation pore; other site 367737000591 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 367737000592 putative acyl-acceptor binding pocket; other site 367737000593 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 367737000594 acyl-activating enzyme (AAE) consensus motif; other site 367737000595 putative AMP binding site [chemical binding]; other site 367737000596 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367737000597 metal binding triad; other site 367737000598 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 367737000599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 367737000600 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 367737000601 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 367737000602 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737000603 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737000604 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737000605 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737000606 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737000607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737000608 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737000609 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 367737000610 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 367737000611 Nitrogen regulatory protein P-II; Region: P-II; smart00938 367737000612 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 367737000613 active site 367737000614 substrate binding pocket [chemical binding]; other site 367737000615 dimer interface [polypeptide binding]; other site 367737000616 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 367737000617 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 367737000618 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 367737000619 Flagellar P-ring protein; Region: FlgI; pfam02119 367737000620 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 367737000621 Uncharacterized conserved protein [Function unknown]; Region: COG3334 367737000622 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 367737000623 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 367737000624 Flagellar L-ring protein; Region: FlgH; pfam02107 367737000625 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 367737000626 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 367737000627 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737000628 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 367737000629 flagellar protein FliS; Validated; Region: fliS; PRK05685 367737000630 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 367737000631 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 367737000632 Ligand Binding Site [chemical binding]; other site 367737000633 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 367737000634 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 367737000635 pantoate--beta-alanine ligase; Region: panC; TIGR00018 367737000636 Pantoate-beta-alanine ligase; Region: PanC; cd00560 367737000637 active site 367737000638 ATP-binding site [chemical binding]; other site 367737000639 pantoate-binding site; other site 367737000640 HXXH motif; other site 367737000641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 367737000642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737000643 dimer interface [polypeptide binding]; other site 367737000644 conserved gate region; other site 367737000645 putative PBP binding loops; other site 367737000646 ABC-ATPase subunit interface; other site 367737000647 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 367737000648 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 367737000649 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 367737000650 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 367737000651 FAD binding site [chemical binding]; other site 367737000652 phosphoserine phosphatase SerB; Region: serB; TIGR00338 367737000653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737000654 motif II; other site 367737000655 Class I aldolases; Region: Aldolase_Class_I; cl17187 367737000656 transaldolase; Provisional; Region: PRK03903 367737000657 catalytic residue [active] 367737000658 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 367737000659 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 367737000660 Virulence protein [General function prediction only]; Region: COG3943 367737000661 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 367737000662 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 367737000663 ArsC family; Region: ArsC; pfam03960 367737000664 catalytic residue [active] 367737000665 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 367737000666 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 367737000667 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 367737000668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 367737000669 TrkA-C domain; Region: TrkA_C; pfam02080 367737000670 hypothetical protein; Provisional; Region: PRK05839 367737000671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737000672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737000673 homodimer interface [polypeptide binding]; other site 367737000674 catalytic residue [active] 367737000675 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 367737000676 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 367737000677 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367737000678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367737000679 DNA protecting protein DprA; Region: dprA; TIGR00732 367737000680 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 367737000681 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 367737000682 putative active site [active] 367737000683 NodB motif; other site 367737000684 ketol-acid reductoisomerase; Provisional; Region: PRK05479 367737000685 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 367737000686 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 367737000687 Exoribonuclease R [Transcription]; Region: VacB; COG0557 367737000688 RNB domain; Region: RNB; pfam00773 367737000689 FliW protein; Region: FliW; pfam02623 367737000690 DNA polymerase III subunit delta; Validated; Region: PRK08487 367737000691 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 367737000692 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 367737000693 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 367737000694 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 367737000695 dimer interface [polypeptide binding]; other site 367737000696 ssDNA binding site [nucleotide binding]; other site 367737000697 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367737000698 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 367737000699 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 367737000700 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 367737000701 active site 367737000702 HIGH motif; other site 367737000703 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 367737000704 KMSKS motif; other site 367737000705 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 367737000706 tRNA binding surface [nucleotide binding]; other site 367737000707 anticodon binding site; other site 367737000708 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 367737000709 NusA N-terminal domain; Region: NusA_N; pfam08529 367737000710 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 367737000711 RNA binding site [nucleotide binding]; other site 367737000712 homodimer interface [polypeptide binding]; other site 367737000713 NusA-like KH domain; Region: KH_5; pfam13184 367737000714 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 367737000715 G-X-X-G motif; other site 367737000716 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 367737000717 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 367737000718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737000719 FeS/SAM binding site; other site 367737000720 TRAM domain; Region: TRAM; pfam01938 367737000721 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 367737000722 putative acyl-acceptor binding pocket; other site 367737000723 hypothetical protein; Provisional; Region: PRK08444 367737000724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737000725 FeS/SAM binding site; other site 367737000726 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 367737000727 active site clefts [active] 367737000728 zinc binding site [ion binding]; other site 367737000729 dimer interface [polypeptide binding]; other site 367737000730 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 367737000731 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 367737000732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737000733 catalytic residue [active] 367737000734 hypothetical protein; Reviewed; Region: PRK12497 367737000735 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 367737000736 thiS-thiF/thiG interaction site; other site 367737000737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737000738 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737000739 ligand binding site [chemical binding]; other site 367737000740 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 367737000741 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 367737000742 domain interfaces; other site 367737000743 active site 367737000744 acetylornithine aminotransferase; Provisional; Region: PRK02627 367737000745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 367737000746 inhibitor-cofactor binding pocket; inhibition site 367737000747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737000748 catalytic residue [active] 367737000749 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 367737000750 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 367737000751 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 367737000752 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 367737000753 para-aminobenzoate synthase component I; Validated; Region: PRK07093 367737000754 Isochorismatase family; Region: Isochorismatase; pfam00857 367737000755 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 367737000756 catalytic triad [active] 367737000757 conserved cis-peptide bond; other site 367737000758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737000759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737000760 active site 367737000761 phosphorylation site [posttranslational modification] 367737000762 dimerization interface [polypeptide binding]; other site 367737000763 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737000764 DNA binding site [nucleotide binding] 367737000765 hypothetical protein; Provisional; Region: PRK07101 367737000766 substrate-cofactor binding pocket; other site 367737000767 homodimer interface [polypeptide binding]; other site 367737000768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737000769 catalytic residue [active] 367737000770 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 367737000771 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 367737000772 PhnA protein; Region: PhnA; pfam03831 367737000773 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 367737000774 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367737000775 hypothetical protein; Provisional; Region: PRK10621 367737000776 HPP family; Region: HPP; pfam04982 367737000777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 367737000778 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 367737000779 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 367737000780 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737000781 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737000782 ligand binding site [chemical binding]; other site 367737000783 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 367737000784 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 367737000785 putative ligand binding site [chemical binding]; other site 367737000786 putative NAD binding site [chemical binding]; other site 367737000787 catalytic site [active] 367737000788 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 367737000789 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 367737000790 tetramer interface [polypeptide binding]; other site 367737000791 active site 367737000792 Mg2+/Mn2+ binding site [ion binding]; other site 367737000793 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 367737000794 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 367737000795 dimer interface [polypeptide binding]; other site 367737000796 active site 367737000797 citrylCoA binding site [chemical binding]; other site 367737000798 oxalacetate/citrate binding site [chemical binding]; other site 367737000799 coenzyme A binding site [chemical binding]; other site 367737000800 catalytic triad [active] 367737000801 aconitate hydratase; Validated; Region: PRK09277 367737000802 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 367737000803 substrate binding site [chemical binding]; other site 367737000804 ligand binding site [chemical binding]; other site 367737000805 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 367737000806 substrate binding site [chemical binding]; other site 367737000807 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 367737000808 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 367737000809 Isochorismatase family; Region: Isochorismatase; pfam00857 367737000810 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 367737000811 catalytic triad [active] 367737000812 dimer interface [polypeptide binding]; other site 367737000813 conserved cis-peptide bond; other site 367737000814 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 367737000815 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 367737000816 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 367737000817 domain interfaces; other site 367737000818 active site 367737000819 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 367737000820 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 367737000821 catalytic residues [active] 367737000822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737000823 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 367737000824 Walker A motif; other site 367737000825 ATP binding site [chemical binding]; other site 367737000826 Walker B motif; other site 367737000827 arginine finger; other site 367737000828 glutamate racemase; Provisional; Region: PRK00865 367737000829 glutamate dehydrogenase; Provisional; Region: PRK09414 367737000830 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 367737000831 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 367737000832 NAD(P) binding site [chemical binding]; other site 367737000833 transcription termination factor Rho; Provisional; Region: rho; PRK09376 367737000834 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 367737000835 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 367737000836 RNA binding site [nucleotide binding]; other site 367737000837 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 367737000838 multimer interface [polypeptide binding]; other site 367737000839 Walker A motif; other site 367737000840 ATP binding site [chemical binding]; other site 367737000841 Walker B motif; other site 367737000842 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 367737000843 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 367737000844 dimer interface [polypeptide binding]; other site 367737000845 decamer (pentamer of dimers) interface [polypeptide binding]; other site 367737000846 catalytic triad [active] 367737000847 peroxidatic and resolving cysteines [active] 367737000848 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 367737000849 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 367737000850 active site 367737000851 multimer interface [polypeptide binding]; other site 367737000852 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 367737000853 putative phosphate acyltransferase; Provisional; Region: PRK05331 367737000854 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 367737000855 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 367737000856 dimer interface [polypeptide binding]; other site 367737000857 active site 367737000858 CoA binding pocket [chemical binding]; other site 367737000859 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 367737000860 GTP/Mg2+ binding site [chemical binding]; other site 367737000861 G5 box; other site 367737000862 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 367737000863 Dynamin family; Region: Dynamin_N; pfam00350 367737000864 G1 box; other site 367737000865 G1 box; other site 367737000866 GTP/Mg2+ binding site [chemical binding]; other site 367737000867 Switch I region; other site 367737000868 G2 box; other site 367737000869 G2 box; other site 367737000870 Switch I region; other site 367737000871 G3 box; other site 367737000872 Switch II region; other site 367737000873 G4 box; other site 367737000874 G5 box; other site 367737000875 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 367737000876 Dynamin family; Region: Dynamin_N; pfam00350 367737000877 G1 box; other site 367737000878 GTP/Mg2+ binding site [chemical binding]; other site 367737000879 G2 box; other site 367737000880 Switch I region; other site 367737000881 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 367737000882 G3 box; other site 367737000883 Switch II region; other site 367737000884 GTP/Mg2+ binding site [chemical binding]; other site 367737000885 G4 box; other site 367737000886 G5 box; other site 367737000887 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 367737000888 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 367737000889 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 367737000890 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 367737000891 L-aspartate oxidase; Provisional; Region: PRK06175 367737000892 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 367737000893 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13553 367737000894 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 367737000895 Iron-sulfur protein interface; other site 367737000896 proximal heme binding site [chemical binding]; other site 367737000897 distal heme binding site [chemical binding]; other site 367737000898 dimer interface [polypeptide binding]; other site 367737000899 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 367737000900 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 367737000901 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 367737000902 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 367737000903 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 367737000904 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 367737000905 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 367737000906 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 367737000907 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 367737000908 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 367737000909 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 367737000910 4Fe-4S binding domain; Region: Fer4; pfam00037 367737000911 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 367737000912 NADH dehydrogenase; Region: NADHdh; cl00469 367737000913 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 367737000914 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 367737000915 catalytic loop [active] 367737000916 iron binding site [ion binding]; other site 367737000917 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 367737000918 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737000919 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737000920 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 367737000921 dimer interface [polypeptide binding]; other site 367737000922 Citrate synthase; Region: Citrate_synt; pfam00285 367737000923 active site 367737000924 citrylCoA binding site [chemical binding]; other site 367737000925 NADH binding [chemical binding]; other site 367737000926 cationic pore residues; other site 367737000927 oxalacetate/citrate binding site [chemical binding]; other site 367737000928 coenzyme A binding site [chemical binding]; other site 367737000929 catalytic triad [active] 367737000930 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 367737000931 SLBB domain; Region: SLBB; pfam10531 367737000932 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 367737000933 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 367737000934 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 367737000935 putative dimer interface [polypeptide binding]; other site 367737000936 [2Fe-2S] cluster binding site [ion binding]; other site 367737000937 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 367737000938 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 367737000939 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 367737000940 NADH dehydrogenase subunit B; Validated; Region: PRK06411 367737000941 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 367737000942 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 367737000943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737000944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737000945 homodimer interface [polypeptide binding]; other site 367737000946 catalytic residue [active] 367737000947 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 367737000948 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 367737000949 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 367737000950 Uncharacterized conserved protein [Function unknown]; Region: COG2966 367737000951 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 367737000952 pantothenate kinase; Reviewed; Region: PRK13333 367737000953 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 367737000954 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 367737000955 Methyltransferase domain; Region: Methyltransf_31; pfam13847 367737000956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737000957 S-adenosylmethionine binding site [chemical binding]; other site 367737000958 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737000959 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 367737000960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737000961 dimer interface [polypeptide binding]; other site 367737000962 putative CheW interface [polypeptide binding]; other site 367737000963 SdiA-regulated; Region: SdiA-regulated; pfam06977 367737000964 SdiA-regulated; Region: SdiA-regulated; cd09971 367737000965 putative active site [active] 367737000966 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 367737000967 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 367737000968 active site 367737000969 HIGH motif; other site 367737000970 dimer interface [polypeptide binding]; other site 367737000971 KMSKS motif; other site 367737000972 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 367737000973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737000974 N-terminal plug; other site 367737000975 ligand-binding site [chemical binding]; other site 367737000976 Predicted membrane protein [Function unknown]; Region: COG3503 367737000977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737000978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737000979 Methyltransferase domain; Region: Methyltransf_31; pfam13847 367737000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737000981 S-adenosylmethionine binding site [chemical binding]; other site 367737000982 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 367737000983 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737000984 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737000985 N-terminal plug; other site 367737000986 ligand-binding site [chemical binding]; other site 367737000987 Helix-turn-helix domain; Region: HTH_18; pfam12833 367737000988 Predicted membrane protein [Function unknown]; Region: COG1971 367737000989 Domain of unknown function DUF; Region: DUF204; pfam02659 367737000990 Domain of unknown function DUF; Region: DUF204; pfam02659 367737000991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737000992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737000993 putative substrate translocation pore; other site 367737000994 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 367737000995 muropeptide transporter; Validated; Region: ampG; cl17669 367737000996 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367737000997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737000998 Walker A/P-loop; other site 367737000999 ATP binding site [chemical binding]; other site 367737001000 Q-loop/lid; other site 367737001001 ABC transporter signature motif; other site 367737001002 Walker B; other site 367737001003 D-loop; other site 367737001004 H-loop/switch region; other site 367737001005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737001006 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 367737001007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737001008 Walker A/P-loop; other site 367737001009 ATP binding site [chemical binding]; other site 367737001010 Q-loop/lid; other site 367737001011 ABC transporter signature motif; other site 367737001012 Walker B; other site 367737001013 D-loop; other site 367737001014 H-loop/switch region; other site 367737001015 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737001016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737001017 N-terminal plug; other site 367737001018 ligand-binding site [chemical binding]; other site 367737001019 Helix-turn-helix domain; Region: HTH_18; pfam12833 367737001020 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 367737001021 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 367737001022 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 367737001023 putative metal binding site [ion binding]; other site 367737001024 putative homodimer interface [polypeptide binding]; other site 367737001025 putative homotetramer interface [polypeptide binding]; other site 367737001026 putative homodimer-homodimer interface [polypeptide binding]; other site 367737001027 putative allosteric switch controlling residues; other site 367737001028 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 367737001029 seryl-tRNA synthetase; Provisional; Region: PRK05431 367737001030 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 367737001031 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 367737001032 dimer interface [polypeptide binding]; other site 367737001033 active site 367737001034 motif 1; other site 367737001035 motif 2; other site 367737001036 motif 3; other site 367737001037 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 367737001038 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 367737001039 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 367737001040 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 367737001041 PAS fold; Region: PAS_4; pfam08448 367737001042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 367737001043 putative active site [active] 367737001044 heme pocket [chemical binding]; other site 367737001045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737001046 metal binding site [ion binding]; metal-binding site 367737001047 active site 367737001048 I-site; other site 367737001049 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737001050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001051 PAS fold; Region: PAS_3; pfam08447 367737001052 putative active site [active] 367737001053 heme pocket [chemical binding]; other site 367737001054 NapD protein; Region: NapD; cl01163 367737001055 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 367737001056 ferredoxin-type protein NapF; Region: napF; TIGR00402 367737001057 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 367737001058 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 367737001059 4Fe-4S binding domain; Region: Fer4_5; pfam12801 367737001060 4Fe-4S binding domain; Region: Fer4_5; pfam12801 367737001061 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 367737001062 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 367737001063 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 367737001064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737001065 molybdopterin cofactor binding site; other site 367737001066 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737001067 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737001068 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 367737001069 molybdopterin cofactor binding site; other site 367737001070 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 367737001071 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 367737001072 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 367737001073 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 367737001074 DctM-like transporters; Region: DctM; pfam06808 367737001075 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737001076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001078 ATP binding site [chemical binding]; other site 367737001079 Mg2+ binding site [ion binding]; other site 367737001080 G-X-G motif; other site 367737001081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737001082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001083 active site 367737001084 phosphorylation site [posttranslational modification] 367737001085 intermolecular recognition site; other site 367737001086 dimerization interface [polypeptide binding]; other site 367737001087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737001088 DNA binding site [nucleotide binding] 367737001089 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 367737001090 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 367737001091 active site 367737001092 SAM binding site [chemical binding]; other site 367737001093 homodimer interface [polypeptide binding]; other site 367737001094 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 367737001095 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 367737001096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367737001097 ligand binding site [chemical binding]; other site 367737001098 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 367737001099 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 367737001100 hypothetical protein; Provisional; Region: PRK07394 367737001101 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 367737001102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737001103 FeS/SAM binding site; other site 367737001104 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 367737001105 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 367737001106 16S/18S rRNA binding site [nucleotide binding]; other site 367737001107 S13e-L30e interaction site [polypeptide binding]; other site 367737001108 25S rRNA binding site [nucleotide binding]; other site 367737001109 Rrf2 family protein; Region: rrf2_super; TIGR00738 367737001110 Transcriptional regulator; Region: Rrf2; pfam02082 367737001111 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 367737001112 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 367737001113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001114 HAMP domain; Region: HAMP; pfam00672 367737001115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737001116 dimer interface [polypeptide binding]; other site 367737001117 phosphorylation site [posttranslational modification] 367737001118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001119 ATP binding site [chemical binding]; other site 367737001120 Mg2+ binding site [ion binding]; other site 367737001121 G-X-G motif; other site 367737001122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737001123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001124 active site 367737001125 phosphorylation site [posttranslational modification] 367737001126 intermolecular recognition site; other site 367737001127 dimerization interface [polypeptide binding]; other site 367737001128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737001129 DNA binding site [nucleotide binding] 367737001130 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 367737001131 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 367737001132 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 367737001133 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 367737001134 active site 367737001135 intersubunit interface [polypeptide binding]; other site 367737001136 zinc binding site [ion binding]; other site 367737001137 Na+ binding site [ion binding]; other site 367737001138 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 367737001139 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 367737001140 NAD(P) binding site [chemical binding]; other site 367737001141 catalytic residues [active] 367737001142 Protein of unknown function (DUF779); Region: DUF779; cl01432 367737001143 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 367737001144 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 367737001145 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 367737001146 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 367737001147 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 367737001148 catalytic residue [active] 367737001149 shikimate kinase; Reviewed; Region: aroK; PRK00131 367737001150 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 367737001151 ADP binding site [chemical binding]; other site 367737001152 magnesium binding site [ion binding]; other site 367737001153 putative shikimate binding site; other site 367737001154 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 367737001155 histidinol dehydrogenase; Region: hisD; TIGR00069 367737001156 NAD binding site [chemical binding]; other site 367737001157 dimerization interface [polypeptide binding]; other site 367737001158 product binding site; other site 367737001159 substrate binding site [chemical binding]; other site 367737001160 zinc binding site [ion binding]; other site 367737001161 catalytic residues [active] 367737001162 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 367737001163 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 367737001164 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 367737001165 substrate binding pocket [chemical binding]; other site 367737001166 chain length determination region; other site 367737001167 substrate-Mg2+ binding site; other site 367737001168 catalytic residues [active] 367737001169 aspartate-rich region 1; other site 367737001170 active site lid residues [active] 367737001171 aspartate-rich region 2; other site 367737001172 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 367737001173 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 367737001174 tRNA; other site 367737001175 putative tRNA binding site [nucleotide binding]; other site 367737001176 putative NADP binding site [chemical binding]; other site 367737001177 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 367737001178 prolyl-tRNA synthetase; Provisional; Region: PRK09194 367737001179 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367737001180 motif 1; other site 367737001181 dimer interface [polypeptide binding]; other site 367737001182 active site 367737001183 motif 2; other site 367737001184 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 367737001185 putative deacylase active site [active] 367737001186 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367737001187 active site 367737001188 motif 3; other site 367737001189 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 367737001190 anticodon binding site; other site 367737001191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 367737001192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 367737001193 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 367737001194 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 367737001195 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 367737001196 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 367737001197 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 367737001198 active site 367737001199 catalytic triad [active] 367737001200 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 367737001201 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 367737001202 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 367737001203 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 367737001204 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 367737001205 Protein export membrane protein; Region: SecD_SecF; pfam02355 367737001206 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 367737001207 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 367737001208 ligand binding site [chemical binding]; other site 367737001209 flagellar motor protein MotA; Validated; Region: PRK08456 367737001210 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 367737001211 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 367737001212 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 367737001213 HIGH motif; other site 367737001214 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 367737001215 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 367737001216 active site 367737001217 KMSKS motif; other site 367737001218 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 367737001219 tRNA binding surface [nucleotide binding]; other site 367737001220 Lipopolysaccharide-assembly; Region: LptE; pfam04390 367737001221 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 367737001222 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 367737001223 DEAD-like helicases superfamily; Region: DEXDc; smart00487 367737001224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737001225 ATP binding site [chemical binding]; other site 367737001226 putative Mg++ binding site [ion binding]; other site 367737001227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737001228 nucleotide binding region [chemical binding]; other site 367737001229 ATP-binding site [chemical binding]; other site 367737001230 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 367737001231 putative acyl-acceptor binding pocket; other site 367737001232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 367737001233 transferase, transferring glycosyl groups; Region: PLN02939 367737001234 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 367737001235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737001236 ATP binding site [chemical binding]; other site 367737001237 putative Mg++ binding site [ion binding]; other site 367737001238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737001239 nucleotide binding region [chemical binding]; other site 367737001240 ATP-binding site [chemical binding]; other site 367737001241 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 367737001242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 367737001243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367737001244 Coenzyme A binding pocket [chemical binding]; other site 367737001245 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367737001246 putative catalytic site [active] 367737001247 putative metal binding site [ion binding]; other site 367737001248 putative phosphate binding site [ion binding]; other site 367737001249 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 367737001250 dimer interface [polypeptide binding]; other site 367737001251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737001252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001253 active site 367737001254 phosphorylation site [posttranslational modification] 367737001255 intermolecular recognition site; other site 367737001256 dimerization interface [polypeptide binding]; other site 367737001257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737001258 DNA binding site [nucleotide binding] 367737001259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 367737001261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001262 ATP binding site [chemical binding]; other site 367737001263 Mg2+ binding site [ion binding]; other site 367737001264 G-X-G motif; other site 367737001265 flavoprotein, HI0933 family; Region: TIGR00275 367737001266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001267 dimer interface [polypeptide binding]; other site 367737001268 putative CheW interface [polypeptide binding]; other site 367737001269 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 367737001270 Response regulator receiver domain; Region: Response_reg; pfam00072 367737001271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001272 active site 367737001273 phosphorylation site [posttranslational modification] 367737001274 intermolecular recognition site; other site 367737001275 dimerization interface [polypeptide binding]; other site 367737001276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001277 PAS domain; Region: PAS_9; pfam13426 367737001278 putative active site [active] 367737001279 heme pocket [chemical binding]; other site 367737001280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001282 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 367737001283 putative active site [active] 367737001284 heme pocket [chemical binding]; other site 367737001285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001286 putative active site [active] 367737001287 heme pocket [chemical binding]; other site 367737001288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737001289 dimer interface [polypeptide binding]; other site 367737001290 phosphorylation site [posttranslational modification] 367737001291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001292 ATP binding site [chemical binding]; other site 367737001293 Mg2+ binding site [ion binding]; other site 367737001294 G-X-G motif; other site 367737001295 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 367737001296 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 367737001297 putative active site [active] 367737001298 metal binding site [ion binding]; metal-binding site 367737001299 homodimer binding site [polypeptide binding]; other site 367737001300 conjugal transfer protein TraL; Provisional; Region: PRK13886 367737001301 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 367737001302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737001303 S-adenosylmethionine binding site [chemical binding]; other site 367737001304 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 367737001305 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 367737001306 generic binding surface II; other site 367737001307 generic binding surface I; other site 367737001308 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 367737001309 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 367737001310 active site 367737001311 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 367737001312 tetramerization interface [polypeptide binding]; other site 367737001313 active site 367737001314 hypothetical protein; Provisional; Region: PRK03762 367737001315 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 367737001316 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 367737001317 substrate binding pocket [chemical binding]; other site 367737001318 chain length determination region; other site 367737001319 substrate-Mg2+ binding site; other site 367737001320 catalytic residues [active] 367737001321 aspartate-rich region 1; other site 367737001322 active site lid residues [active] 367737001323 aspartate-rich region 2; other site 367737001324 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 367737001325 oligomerisation interface [polypeptide binding]; other site 367737001326 mobile loop; other site 367737001327 roof hairpin; other site 367737001328 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 367737001329 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 367737001330 ring oligomerisation interface [polypeptide binding]; other site 367737001331 ATP/Mg binding site [chemical binding]; other site 367737001332 stacking interactions; other site 367737001333 hinge regions; other site 367737001334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 367737001335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737001336 dimer interface [polypeptide binding]; other site 367737001337 phosphorylation site [posttranslational modification] 367737001338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001339 ATP binding site [chemical binding]; other site 367737001340 G-X-G motif; other site 367737001341 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 367737001342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001343 active site 367737001344 phosphorylation site [posttranslational modification] 367737001345 intermolecular recognition site; other site 367737001346 dimerization interface [polypeptide binding]; other site 367737001347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737001348 DNA binding site [nucleotide binding] 367737001349 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 367737001350 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 367737001351 putative active site [active] 367737001352 putative metal binding site [ion binding]; other site 367737001353 YceI-like domain; Region: YceI; pfam04264 367737001354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737001355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367737001356 Walker A/P-loop; other site 367737001357 ATP binding site [chemical binding]; other site 367737001358 Q-loop/lid; other site 367737001359 ABC transporter signature motif; other site 367737001360 Walker B; other site 367737001361 D-loop; other site 367737001362 H-loop/switch region; other site 367737001363 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367737001364 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 367737001365 FtsX-like permease family; Region: FtsX; pfam02687 367737001366 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 367737001367 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 367737001368 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 367737001369 active site 367737001370 dimerization interface [polypeptide binding]; other site 367737001371 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 367737001372 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 367737001373 glutaminase active site [active] 367737001374 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 367737001375 dimer interface [polypeptide binding]; other site 367737001376 active site 367737001377 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 367737001378 dimer interface [polypeptide binding]; other site 367737001379 active site 367737001380 S-adenosylmethionine synthetase; Validated; Region: PRK05250 367737001381 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 367737001382 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 367737001383 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 367737001384 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 367737001385 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 367737001386 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 367737001387 thiamine phosphate binding site [chemical binding]; other site 367737001388 active site 367737001389 pyrophosphate binding site [ion binding]; other site 367737001390 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 367737001391 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 367737001392 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 367737001393 FMN binding site [chemical binding]; other site 367737001394 active site 367737001395 catalytic residues [active] 367737001396 substrate binding site [chemical binding]; other site 367737001397 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 367737001398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737001399 S-adenosylmethionine binding site [chemical binding]; other site 367737001400 FtsH Extracellular; Region: FtsH_ext; pfam06480 367737001401 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 367737001402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737001403 Walker A motif; other site 367737001404 ATP binding site [chemical binding]; other site 367737001405 Walker B motif; other site 367737001406 arginine finger; other site 367737001407 Peptidase family M41; Region: Peptidase_M41; pfam01434 367737001408 Response regulator receiver domain; Region: Response_reg; pfam00072 367737001409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001410 active site 367737001411 phosphorylation site [posttranslational modification] 367737001412 intermolecular recognition site; other site 367737001413 dimerization interface [polypeptide binding]; other site 367737001414 PAS domain; Region: PAS_9; pfam13426 367737001415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001416 putative active site [active] 367737001417 heme pocket [chemical binding]; other site 367737001418 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 367737001419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001420 putative active site [active] 367737001421 heme pocket [chemical binding]; other site 367737001422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737001423 Zn2+ binding site [ion binding]; other site 367737001424 Mg2+ binding site [ion binding]; other site 367737001425 Response regulator receiver domain; Region: Response_reg; pfam00072 367737001426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001427 active site 367737001428 phosphorylation site [posttranslational modification] 367737001429 intermolecular recognition site; other site 367737001430 dimerization interface [polypeptide binding]; other site 367737001431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 367737001433 dimerization interface [polypeptide binding]; other site 367737001434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737001435 dimer interface [polypeptide binding]; other site 367737001436 phosphorylation site [posttranslational modification] 367737001437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001438 ATP binding site [chemical binding]; other site 367737001439 Mg2+ binding site [ion binding]; other site 367737001440 G-X-G motif; other site 367737001441 2-isopropylmalate synthase; Validated; Region: PRK00915 367737001442 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 367737001443 active site 367737001444 catalytic residues [active] 367737001445 metal binding site [ion binding]; metal-binding site 367737001446 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 367737001447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 367737001448 catalytic residues [active] 367737001449 Haem-binding domain; Region: Haem_bd; pfam14376 367737001450 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 367737001451 MutS domain I; Region: MutS_I; pfam01624 367737001452 MutS domain III; Region: MutS_III; pfam05192 367737001453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737001454 Walker A/P-loop; other site 367737001455 ATP binding site [chemical binding]; other site 367737001456 Q-loop/lid; other site 367737001457 ABC transporter signature motif; other site 367737001458 Walker B; other site 367737001459 D-loop; other site 367737001460 H-loop/switch region; other site 367737001461 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 367737001462 active site 367737001463 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 367737001464 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737001465 Outer membrane efflux protein; Region: OEP; pfam02321 367737001466 Outer membrane efflux protein; Region: OEP; pfam02321 367737001467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367737001468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367737001469 Helix-turn-helix domain; Region: HTH_18; pfam12833 367737001470 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 367737001471 Cytochrome c; Region: Cytochrom_C; pfam00034 367737001472 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098 367737001473 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 367737001474 Domain of unknown function (DUF1928); Region: DUF1928; pfam09100 367737001475 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 367737001476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737001477 FeS/SAM binding site; other site 367737001478 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 367737001479 Quinohemoprotein amine dehydrogenase, gamma subunit; Region: QH-AmDH_gamma; pfam08992 367737001480 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 367737001481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737001482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367737001483 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 367737001484 Walker A/P-loop; other site 367737001485 ATP binding site [chemical binding]; other site 367737001486 Q-loop/lid; other site 367737001487 ABC transporter signature motif; other site 367737001488 Walker B; other site 367737001489 D-loop; other site 367737001490 H-loop/switch region; other site 367737001491 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 367737001492 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 367737001493 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737001494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737001495 metal binding site [ion binding]; metal-binding site 367737001496 active site 367737001497 I-site; other site 367737001498 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 367737001499 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 367737001500 catalytic residues [active] 367737001501 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 367737001502 TIGR01777 family protein; Region: yfcH 367737001503 putative NAD(P) binding site [chemical binding]; other site 367737001504 putative active site [active] 367737001505 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 367737001506 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 367737001507 putative active site [active] 367737001508 oxyanion strand; other site 367737001509 catalytic triad [active] 367737001510 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 367737001511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737001512 active site 367737001513 GTP-binding protein LepA; Provisional; Region: PRK05433 367737001514 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 367737001515 G1 box; other site 367737001516 putative GEF interaction site [polypeptide binding]; other site 367737001517 GTP/Mg2+ binding site [chemical binding]; other site 367737001518 Switch I region; other site 367737001519 G2 box; other site 367737001520 G3 box; other site 367737001521 Switch II region; other site 367737001522 G4 box; other site 367737001523 G5 box; other site 367737001524 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 367737001525 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 367737001526 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 367737001527 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 367737001528 putative homodimer interface [polypeptide binding]; other site 367737001529 putative homotetramer interface [polypeptide binding]; other site 367737001530 putative allosteric switch controlling residues; other site 367737001531 putative metal binding site [ion binding]; other site 367737001532 putative homodimer-homodimer interface [polypeptide binding]; other site 367737001533 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 367737001534 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 367737001535 metal-binding site [ion binding] 367737001536 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367737001537 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 367737001538 metal-binding site [ion binding] 367737001539 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 367737001540 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737001541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737001542 ligand binding site [chemical binding]; other site 367737001543 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 367737001544 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 367737001545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737001546 active site 367737001547 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 367737001548 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 367737001549 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 367737001550 Ligand Binding Site [chemical binding]; other site 367737001551 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 367737001552 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 367737001553 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 367737001554 catalytic center binding site [active] 367737001555 ATP binding site [chemical binding]; other site 367737001556 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 367737001557 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 367737001558 active site 367737001559 Dehydroquinase class II; Region: DHquinase_II; pfam01220 367737001560 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 367737001561 trimer interface [polypeptide binding]; other site 367737001562 active site 367737001563 dimer interface [polypeptide binding]; other site 367737001564 chlorohydrolase; Provisional; Region: PRK08418 367737001565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 367737001566 active site 367737001567 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 367737001568 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 367737001569 tandem repeat interface [polypeptide binding]; other site 367737001570 oligomer interface [polypeptide binding]; other site 367737001571 active site residues [active] 367737001572 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 367737001573 propionate/acetate kinase; Provisional; Region: PRK12379 367737001574 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 367737001575 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 367737001576 propionate/acetate kinase; Provisional; Region: PRK12379 367737001577 Cation efflux family; Region: Cation_efflux; cl00316 367737001578 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 367737001579 propionate/acetate kinase; Provisional; Region: PRK12379 367737001580 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367737001581 active site 367737001582 catalytic site [active] 367737001583 substrate binding site [chemical binding]; other site 367737001584 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 367737001585 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367737001586 ligand binding site [chemical binding]; other site 367737001587 flexible hinge region; other site 367737001588 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 367737001589 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367737001590 metal binding triad; other site 367737001591 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 367737001592 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 367737001593 Na binding site [ion binding]; other site 367737001594 Protein of unknown function, DUF485; Region: DUF485; pfam04341 367737001595 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 367737001596 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 367737001597 Na binding site [ion binding]; other site 367737001598 Protein of unknown function, DUF485; Region: DUF485; pfam04341 367737001599 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 367737001600 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367737001601 active site 367737001602 catalytic site [active] 367737001603 substrate binding site [chemical binding]; other site 367737001604 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 367737001605 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367737001606 ligand binding site [chemical binding]; other site 367737001607 flexible hinge region; other site 367737001608 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 367737001609 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367737001610 metal binding triad; other site 367737001611 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 367737001612 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 367737001613 Na binding site [ion binding]; other site 367737001614 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 367737001615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001617 active site 367737001618 phosphorylation site [posttranslational modification] 367737001619 intermolecular recognition site; other site 367737001620 dimerization interface [polypeptide binding]; other site 367737001621 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737001622 DNA binding site [nucleotide binding] 367737001623 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737001624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737001626 dimer interface [polypeptide binding]; other site 367737001627 phosphorylation site [posttranslational modification] 367737001628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737001629 ATP binding site [chemical binding]; other site 367737001630 Mg2+ binding site [ion binding]; other site 367737001631 G-X-G motif; other site 367737001632 Competence-damaged protein; Region: CinA; pfam02464 367737001633 Predicted dehydrogenase [General function prediction only]; Region: COG0579 367737001634 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 367737001635 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 367737001636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367737001637 active site 367737001638 HIGH motif; other site 367737001639 nucleotide binding site [chemical binding]; other site 367737001640 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 367737001641 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 367737001642 active site 367737001643 KMSKS motif; other site 367737001644 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 367737001645 tRNA binding surface [nucleotide binding]; other site 367737001646 anticodon binding site; other site 367737001647 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 367737001648 NifU-like domain; Region: NifU; cl00484 367737001649 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 367737001650 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367737001651 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367737001652 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 367737001653 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 367737001654 gating phenylalanine in ion channel; other site 367737001655 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367737001656 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367737001657 active site 367737001658 catalytic tetrad [active] 367737001659 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 367737001660 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 367737001661 HAMP domain; Region: HAMP; pfam00672 367737001662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737001663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001664 dimer interface [polypeptide binding]; other site 367737001665 putative CheW interface [polypeptide binding]; other site 367737001666 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 367737001667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001668 dimer interface [polypeptide binding]; other site 367737001669 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737001670 putative CheW interface [polypeptide binding]; other site 367737001671 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 367737001672 active site 367737001673 nuclease NucT; Provisional; Region: PRK13912 367737001674 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 367737001675 putative active site [active] 367737001676 catalytic site [active] 367737001677 Peptidase family M48; Region: Peptidase_M48; pfam01435 367737001678 RmuC family; Region: RmuC; pfam02646 367737001679 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367737001680 EamA-like transporter family; Region: EamA; pfam00892 367737001681 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 367737001682 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 367737001683 dimer interface [polypeptide binding]; other site 367737001684 putative functional site; other site 367737001685 putative MPT binding site; other site 367737001686 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 367737001687 Ligand Binding Site [chemical binding]; other site 367737001688 Uncharacterized conserved protein [Function unknown]; Region: COG1683 367737001689 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 367737001690 SprA-related family; Region: SprA-related; pfam12118 367737001691 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 367737001692 rRNA interaction site [nucleotide binding]; other site 367737001693 S8 interaction site; other site 367737001694 putative laminin-1 binding site; other site 367737001695 elongation factor Ts; Provisional; Region: tsf; PRK09377 367737001696 UBA/TS-N domain; Region: UBA; pfam00627 367737001697 Elongation factor TS; Region: EF_TS; pfam00889 367737001698 Elongation factor TS; Region: EF_TS; pfam00889 367737001699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737001700 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367737001701 Walker A/P-loop; other site 367737001702 ATP binding site [chemical binding]; other site 367737001703 Q-loop/lid; other site 367737001704 ABC transporter signature motif; other site 367737001705 Walker B; other site 367737001706 D-loop; other site 367737001707 H-loop/switch region; other site 367737001708 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 367737001709 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 367737001710 catalytic site [active] 367737001711 G-X2-G-X-G-K; other site 367737001712 Response regulator receiver domain; Region: Response_reg; pfam00072 367737001713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001714 active site 367737001715 phosphorylation site [posttranslational modification] 367737001716 intermolecular recognition site; other site 367737001717 dimerization interface [polypeptide binding]; other site 367737001718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737001719 metal binding site [ion binding]; metal-binding site 367737001720 active site 367737001721 I-site; other site 367737001722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737001723 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 367737001724 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 367737001725 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 367737001726 metal-binding site [ion binding] 367737001727 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367737001728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737001729 motif II; other site 367737001730 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 367737001731 Cytochrome c; Region: Cytochrom_C; cl11414 367737001732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737001733 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367737001734 Walker A/P-loop; other site 367737001735 ATP binding site [chemical binding]; other site 367737001736 Q-loop/lid; other site 367737001737 ABC transporter signature motif; other site 367737001738 Walker B; other site 367737001739 D-loop; other site 367737001740 H-loop/switch region; other site 367737001741 ferrochelatase; Reviewed; Region: hemH; PRK00035 367737001742 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 367737001743 C-terminal domain interface [polypeptide binding]; other site 367737001744 active site 367737001745 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 367737001746 active site 367737001747 N-terminal domain interface [polypeptide binding]; other site 367737001748 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 367737001749 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 367737001750 G1 box; other site 367737001751 GTP/Mg2+ binding site [chemical binding]; other site 367737001752 Switch I region; other site 367737001753 G2 box; other site 367737001754 G3 box; other site 367737001755 Switch II region; other site 367737001756 G4 box; other site 367737001757 G5 box; other site 367737001758 Nucleoside recognition; Region: Gate; pfam07670 367737001759 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 367737001760 Nucleoside recognition; Region: Gate; pfam07670 367737001761 FeoA domain; Region: FeoA; pfam04023 367737001762 Uncharacterized conserved protein [Function unknown]; Region: COG1434 367737001763 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 367737001764 putative active site [active] 367737001765 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737001766 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 367737001767 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 367737001768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 367737001769 dimer interface [polypeptide binding]; other site 367737001770 putative PBP binding regions; other site 367737001771 ABC-ATPase subunit interface; other site 367737001772 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 367737001773 S1 domain; Region: S1_2; pfam13509 367737001774 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 367737001775 RNA binding site [nucleotide binding]; other site 367737001776 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 367737001777 dimer interface [polypeptide binding]; other site 367737001778 catalytic triad [active] 367737001779 peroxidatic and resolving cysteines [active] 367737001780 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 367737001781 Sel1-like repeats; Region: SEL1; smart00671 367737001782 Sel1 repeat; Region: Sel1; cl02723 367737001783 Sel1-like repeats; Region: SEL1; smart00671 367737001784 Sel1-like repeats; Region: SEL1; smart00671 367737001785 Sel1-like repeats; Region: SEL1; smart00671 367737001786 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 367737001787 NnrS protein; Region: NnrS; pfam05940 367737001788 TMAO/DMSO reductase; Reviewed; Region: PRK05363 367737001789 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 367737001790 Moco binding site; other site 367737001791 metal coordination site [ion binding]; other site 367737001792 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 367737001793 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 367737001794 Part of AAA domain; Region: AAA_19; pfam13245 367737001795 Family description; Region: UvrD_C_2; pfam13538 367737001796 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 367737001797 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 367737001798 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 367737001799 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 367737001800 Moco binding site; other site 367737001801 metal coordination site [ion binding]; other site 367737001802 Cytochrome c; Region: Cytochrom_C; pfam00034 367737001803 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 367737001804 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 367737001805 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 367737001806 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 367737001807 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 367737001808 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 367737001809 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 367737001810 Cytochrome c [Energy production and conversion]; Region: COG3258 367737001811 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 367737001812 active site 367737001813 metal binding site [ion binding]; metal-binding site 367737001814 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 367737001815 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 367737001816 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 367737001817 MOSC domain; Region: MOSC; pfam03473 367737001818 DsrE/DsrF-like family; Region: DrsE; cl00672 367737001819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367737001820 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 367737001821 intracellular protease, PfpI family; Region: PfpI; TIGR01382 367737001822 conserved cys residue [active] 367737001823 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 367737001824 HD domain; Region: HD_5; pfam13487 367737001825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737001826 active site residue [active] 367737001827 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 367737001828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367737001829 active site 367737001830 HIGH motif; other site 367737001831 nucleotide binding site [chemical binding]; other site 367737001832 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 367737001833 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 367737001834 active site 367737001835 KMSKS motif; other site 367737001836 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 367737001837 tRNA binding surface [nucleotide binding]; other site 367737001838 anticodon binding site; other site 367737001839 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 367737001840 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 367737001841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737001842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737001843 putative substrate translocation pore; other site 367737001844 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 367737001845 active site 367737001846 dimerization interface [polypeptide binding]; other site 367737001847 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 367737001848 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 367737001849 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 367737001850 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 367737001851 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 367737001852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737001853 Walker A motif; other site 367737001854 ATP binding site [chemical binding]; other site 367737001855 Walker B motif; other site 367737001856 arginine finger; other site 367737001857 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 367737001858 Rhomboid family; Region: Rhomboid; pfam01694 367737001859 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 367737001860 Low molecular weight phosphatase family; Region: LMWPc; cd00115 367737001861 active site 367737001862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737001863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737001864 binding surface 367737001865 TPR motif; other site 367737001866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737001867 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737001868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737001869 binding surface 367737001870 TPR motif; other site 367737001871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737001872 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737001873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737001874 binding surface 367737001875 TPR motif; other site 367737001876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 367737001877 MarR family; Region: MarR; pfam01047 367737001878 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 367737001879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367737001880 non-specific DNA binding site [nucleotide binding]; other site 367737001881 salt bridge; other site 367737001882 sequence-specific DNA binding site [nucleotide binding]; other site 367737001883 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 367737001884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001885 putative active site [active] 367737001886 heme pocket [chemical binding]; other site 367737001887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737001888 putative active site [active] 367737001889 heme pocket [chemical binding]; other site 367737001890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001891 dimer interface [polypeptide binding]; other site 367737001892 putative CheW interface [polypeptide binding]; other site 367737001893 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 367737001894 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 367737001895 EamA-like transporter family; Region: EamA; pfam00892 367737001896 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 367737001897 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367737001898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 367737001899 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 367737001900 Domain of unknown function DUF59; Region: DUF59; cl00941 367737001901 Fe-S metabolism associated domain; Region: SufE; cl00951 367737001902 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 367737001903 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 367737001904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737001905 catalytic residue [active] 367737001906 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 367737001907 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 367737001908 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 367737001909 FeS assembly ATPase SufC; Region: sufC; TIGR01978 367737001910 Walker A/P-loop; other site 367737001911 ATP binding site [chemical binding]; other site 367737001912 Q-loop/lid; other site 367737001913 ABC transporter signature motif; other site 367737001914 Walker B; other site 367737001915 D-loop; other site 367737001916 H-loop/switch region; other site 367737001917 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 367737001918 putative ABC transporter; Region: ycf24; CHL00085 367737001919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367737001920 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 367737001921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737001922 catalytic residue [active] 367737001923 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 367737001924 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 367737001925 trimerization site [polypeptide binding]; other site 367737001926 active site 367737001927 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 367737001928 NifU-like domain; Region: NifU; cl00484 367737001929 FOG: CBS domain [General function prediction only]; Region: COG0517 367737001930 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 367737001931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737001932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737001933 metal binding site [ion binding]; metal-binding site 367737001934 active site 367737001935 I-site; other site 367737001936 argininosuccinate lyase; Provisional; Region: PRK00855 367737001937 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 367737001938 active sites [active] 367737001939 tetramer interface [polypeptide binding]; other site 367737001940 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 367737001941 Response regulator receiver domain; Region: Response_reg; pfam00072 367737001942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001943 active site 367737001944 phosphorylation site [posttranslational modification] 367737001945 intermolecular recognition site; other site 367737001946 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 367737001947 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 367737001948 putative ATP binding site [chemical binding]; other site 367737001949 putative substrate interface [chemical binding]; other site 367737001950 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 367737001951 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 367737001952 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 367737001953 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 367737001954 putative active site [active] 367737001955 putative metal binding site [ion binding]; other site 367737001956 excinuclease ABC subunit B; Provisional; Region: PRK05298 367737001957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737001958 ATP binding site [chemical binding]; other site 367737001959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737001960 nucleotide binding region [chemical binding]; other site 367737001961 ATP-binding site [chemical binding]; other site 367737001962 Ultra-violet resistance protein B; Region: UvrB; pfam12344 367737001963 UvrB/uvrC motif; Region: UVR; pfam02151 367737001964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001965 dimer interface [polypeptide binding]; other site 367737001966 putative CheW interface [polypeptide binding]; other site 367737001967 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 367737001968 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 367737001969 minor groove reading motif; other site 367737001970 helix-hairpin-helix signature motif; other site 367737001971 substrate binding pocket [chemical binding]; other site 367737001972 active site 367737001973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737001974 N-terminal plug; other site 367737001975 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 367737001976 ligand-binding site [chemical binding]; other site 367737001977 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 367737001978 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737001979 N-terminal plug; other site 367737001980 ligand-binding site [chemical binding]; other site 367737001981 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737001982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737001983 dimer interface [polypeptide binding]; other site 367737001984 putative CheW interface [polypeptide binding]; other site 367737001985 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 367737001986 active site 367737001987 GIY-YIG motif/motif A; other site 367737001988 catalytic site [active] 367737001989 metal binding site [ion binding]; metal-binding site 367737001990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737001992 active site 367737001993 phosphorylation site [posttranslational modification] 367737001994 intermolecular recognition site; other site 367737001995 dimerization interface [polypeptide binding]; other site 367737001996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 367737001997 DNA binding site [nucleotide binding] 367737001998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737002000 ATP binding site [chemical binding]; other site 367737002001 Mg2+ binding site [ion binding]; other site 367737002002 G-X-G motif; other site 367737002003 PAS domain; Region: PAS_9; pfam13426 367737002004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737002005 putative active site [active] 367737002006 heme pocket [chemical binding]; other site 367737002007 PAS domain; Region: PAS_9; pfam13426 367737002008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737002009 putative active site [active] 367737002010 heme pocket [chemical binding]; other site 367737002011 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 367737002012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002013 dimer interface [polypeptide binding]; other site 367737002014 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737002015 putative CheW interface [polypeptide binding]; other site 367737002016 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 367737002017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002018 dimer interface [polypeptide binding]; other site 367737002019 putative CheW interface [polypeptide binding]; other site 367737002020 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 367737002021 HD domain; Region: HD_3; pfam13023 367737002022 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 367737002023 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 367737002024 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 367737002025 Catalytic site [active] 367737002026 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 367737002027 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14191 367737002028 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 367737002029 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 367737002030 homodimer interface [polypeptide binding]; other site 367737002031 NADP binding site [chemical binding]; other site 367737002032 substrate binding site [chemical binding]; other site 367737002033 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 367737002034 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 367737002035 5S rRNA interface [nucleotide binding]; other site 367737002036 CTC domain interface [polypeptide binding]; other site 367737002037 L16 interface [polypeptide binding]; other site 367737002038 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 367737002039 putative active site [active] 367737002040 catalytic residue [active] 367737002041 Predicted permeases [General function prediction only]; Region: COG0795 367737002042 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 367737002043 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 367737002044 nudix motif; other site 367737002045 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 367737002046 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 367737002047 active site 367737002048 metal binding site [ion binding]; metal-binding site 367737002049 Nitronate monooxygenase; Region: NMO; pfam03060 367737002050 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 367737002051 FMN binding site [chemical binding]; other site 367737002052 substrate binding site [chemical binding]; other site 367737002053 putative catalytic residue [active] 367737002054 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 367737002055 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 367737002056 active site 367737002057 HIGH motif; other site 367737002058 dimer interface [polypeptide binding]; other site 367737002059 KMSKS motif; other site 367737002060 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737002061 RNA binding surface [nucleotide binding]; other site 367737002062 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 367737002063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737002064 Zn2+ binding site [ion binding]; other site 367737002065 Mg2+ binding site [ion binding]; other site 367737002066 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 367737002067 synthetase active site [active] 367737002068 NTP binding site [chemical binding]; other site 367737002069 metal binding site [ion binding]; metal-binding site 367737002070 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 367737002071 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 367737002072 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 367737002073 putative nucleotide binding site [chemical binding]; other site 367737002074 uridine monophosphate binding site [chemical binding]; other site 367737002075 homohexameric interface [polypeptide binding]; other site 367737002076 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 367737002077 AAA domain; Region: AAA_14; pfam13173 367737002078 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK03946 367737002079 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 367737002080 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 367737002081 active site 367737002082 hydrophilic channel; other site 367737002083 dimerization interface [polypeptide binding]; other site 367737002084 catalytic residues [active] 367737002085 active site lid [active] 367737002086 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 367737002087 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 367737002088 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 367737002089 Sporulation related domain; Region: SPOR; pfam05036 367737002090 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 367737002091 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 367737002092 dimer interface [polypeptide binding]; other site 367737002093 active site 367737002094 glycine-pyridoxal phosphate binding site [chemical binding]; other site 367737002095 folate binding site [chemical binding]; other site 367737002096 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 367737002097 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 367737002098 dimer interface [polypeptide binding]; other site 367737002099 putative anticodon binding site; other site 367737002100 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 367737002101 motif 1; other site 367737002102 active site 367737002103 motif 2; other site 367737002104 motif 3; other site 367737002105 Colicin V production protein; Region: Colicin_V; pfam02674 367737002106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 367737002107 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 367737002108 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 367737002109 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 367737002110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737002111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737002112 metal binding site [ion binding]; metal-binding site 367737002113 active site 367737002114 I-site; other site 367737002115 replicative DNA helicase; Provisional; Region: PRK08506 367737002116 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 367737002117 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 367737002118 Walker A motif; other site 367737002119 ATP binding site [chemical binding]; other site 367737002120 Walker B motif; other site 367737002121 DNA binding loops [nucleotide binding] 367737002122 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 367737002123 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 367737002124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 367737002125 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 367737002126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 367737002127 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 367737002128 putative NAD(P) binding site [chemical binding]; other site 367737002129 active site 367737002130 putative substrate binding site [chemical binding]; other site 367737002131 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 367737002132 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 367737002133 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 367737002134 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 367737002135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 367737002136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 367737002137 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 367737002138 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 367737002139 putative trimer interface [polypeptide binding]; other site 367737002140 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 367737002141 putative CoA binding site [chemical binding]; other site 367737002142 putative trimer interface [polypeptide binding]; other site 367737002143 putative active site [active] 367737002144 putative substrate binding site [chemical binding]; other site 367737002145 putative CoA binding site [chemical binding]; other site 367737002146 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 367737002147 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 367737002148 inhibitor-cofactor binding pocket; inhibition site 367737002149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737002150 catalytic residue [active] 367737002151 hydroxyglutarate oxidase; Provisional; Region: PRK11728 367737002152 Predicted dehydrogenase [General function prediction only]; Region: COG0579 367737002153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737002154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 367737002155 NAD(P) binding site [chemical binding]; other site 367737002156 active site 367737002157 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 367737002158 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 367737002159 inhibitor-cofactor binding pocket; inhibition site 367737002160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737002161 catalytic residue [active] 367737002162 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 367737002163 active site 367737002164 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 367737002165 dimer interface [polypeptide binding]; other site 367737002166 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 367737002167 Ligand Binding Site [chemical binding]; other site 367737002168 Molecular Tunnel; other site 367737002169 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 367737002170 trimer interface [polypeptide binding]; other site 367737002171 active site 367737002172 substrate binding site [chemical binding]; other site 367737002173 CoA binding site [chemical binding]; other site 367737002174 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 367737002175 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 367737002176 Ligand Binding Site [chemical binding]; other site 367737002177 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 367737002178 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 367737002179 putative active site [active] 367737002180 oxyanion strand; other site 367737002181 catalytic triad [active] 367737002182 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 367737002183 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 367737002184 substrate binding site [chemical binding]; other site 367737002185 glutamase interaction surface [polypeptide binding]; other site 367737002186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737002187 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367737002188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737002189 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 367737002190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737002191 Walker A/P-loop; other site 367737002192 ATP binding site [chemical binding]; other site 367737002193 Q-loop/lid; other site 367737002194 ABC transporter signature motif; other site 367737002195 Walker B; other site 367737002196 D-loop; other site 367737002197 H-loop/switch region; other site 367737002198 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 367737002199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737002200 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 367737002201 putative ADP-binding pocket [chemical binding]; other site 367737002202 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 367737002203 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 367737002204 active site 367737002205 dimer interface [polypeptide binding]; other site 367737002206 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 367737002207 Ligand Binding Site [chemical binding]; other site 367737002208 Molecular Tunnel; other site 367737002209 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 367737002210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737002211 putative ADP-binding pocket [chemical binding]; other site 367737002212 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 367737002213 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 367737002214 Mg++ binding site [ion binding]; other site 367737002215 putative catalytic motif [active] 367737002216 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 367737002217 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 367737002218 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 367737002219 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 367737002220 Ligand Binding Site [chemical binding]; other site 367737002221 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 367737002222 trimer interface [polypeptide binding]; other site 367737002223 active site 367737002224 substrate binding site [chemical binding]; other site 367737002225 CoA binding site [chemical binding]; other site 367737002226 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367737002227 O-Antigen ligase; Region: Wzy_C; cl04850 367737002228 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 367737002229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737002230 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 367737002231 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 367737002232 Ligand Binding Site [chemical binding]; other site 367737002233 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 367737002234 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 367737002235 putative active site [active] 367737002236 oxyanion strand; other site 367737002237 catalytic triad [active] 367737002238 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 367737002239 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 367737002240 substrate binding site [chemical binding]; other site 367737002241 glutamase interaction surface [polypeptide binding]; other site 367737002242 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 367737002243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737002244 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 367737002245 active site 367737002246 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 367737002247 homodimer interface [polypeptide binding]; other site 367737002248 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 367737002249 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 367737002250 Ligand binding site; other site 367737002251 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 367737002252 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 367737002253 Mg++ binding site [ion binding]; other site 367737002254 putative catalytic motif [active] 367737002255 putative substrate binding site [chemical binding]; other site 367737002256 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 367737002257 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 367737002258 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 367737002259 NAD(P) binding site [chemical binding]; other site 367737002260 homodimer interface [polypeptide binding]; other site 367737002261 substrate binding site [chemical binding]; other site 367737002262 active site 367737002263 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 367737002264 DNA ligase; Provisional; Region: PRK09125 367737002265 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 367737002266 DNA binding site [nucleotide binding] 367737002267 active site 367737002268 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 367737002269 DNA binding site [nucleotide binding] 367737002270 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737002271 active site 367737002272 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 367737002273 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 367737002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737002275 catalytic residue [active] 367737002276 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 367737002277 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 367737002278 multifunctional aminopeptidase A; Provisional; Region: PRK00913 367737002279 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 367737002280 interface (dimer of trimers) [polypeptide binding]; other site 367737002281 Substrate-binding/catalytic site; other site 367737002282 Zn-binding sites [ion binding]; other site 367737002283 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 367737002284 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 367737002285 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 367737002286 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 367737002287 Outer membrane efflux protein; Region: OEP; pfam02321 367737002288 Outer membrane efflux protein; Region: OEP; pfam02321 367737002289 HlyD family secretion protein; Region: HlyD_2; pfam12700 367737002290 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737002291 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737002292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737002293 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367737002294 Walker A/P-loop; other site 367737002295 ATP binding site [chemical binding]; other site 367737002296 Q-loop/lid; other site 367737002297 ABC transporter signature motif; other site 367737002298 Walker B; other site 367737002299 D-loop; other site 367737002300 H-loop/switch region; other site 367737002301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367737002302 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367737002303 FtsX-like permease family; Region: FtsX; pfam02687 367737002304 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737002305 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737002306 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 367737002307 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367737002308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737002309 active site 367737002310 motif I; other site 367737002311 motif II; other site 367737002312 YtxH-like protein; Region: YtxH; pfam12732 367737002313 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 367737002314 diiron binding motif [ion binding]; other site 367737002315 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 367737002316 metal binding site 2 [ion binding]; metal-binding site 367737002317 putative DNA binding helix; other site 367737002318 metal binding site 1 [ion binding]; metal-binding site 367737002319 dimer interface [polypeptide binding]; other site 367737002320 structural Zn2+ binding site [ion binding]; other site 367737002321 fumarate hydratase; Reviewed; Region: fumC; PRK00485 367737002322 Class II fumarases; Region: Fumarase_classII; cd01362 367737002323 active site 367737002324 tetramer interface [polypeptide binding]; other site 367737002325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 367737002326 Histidine kinase; Region: HisKA_2; pfam07568 367737002327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737002328 ATP binding site [chemical binding]; other site 367737002329 Mg2+ binding site [ion binding]; other site 367737002330 G-X-G motif; other site 367737002331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737002332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002333 active site 367737002334 phosphorylation site [posttranslational modification] 367737002335 intermolecular recognition site; other site 367737002336 dimerization interface [polypeptide binding]; other site 367737002337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 367737002338 DNA binding site [nucleotide binding] 367737002339 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 367737002340 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737002341 N-terminal plug; other site 367737002342 ligand-binding site [chemical binding]; other site 367737002343 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 367737002344 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 367737002345 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 367737002346 active site 367737002347 substrate binding site [chemical binding]; other site 367737002348 FMN binding site [chemical binding]; other site 367737002349 putative catalytic residues [active] 367737002350 enterobactin receptor protein; Provisional; Region: PRK13483 367737002351 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737002352 N-terminal plug; other site 367737002353 ligand-binding site [chemical binding]; other site 367737002354 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 367737002355 Methyltransferase domain; Region: Methyltransf_23; pfam13489 367737002356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737002357 S-adenosylmethionine binding site [chemical binding]; other site 367737002358 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 367737002359 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 367737002360 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 367737002361 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 367737002362 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 367737002363 Protein of unknown function (DUF466); Region: DUF466; pfam04328 367737002364 carbon starvation protein A; Provisional; Region: PRK15015 367737002365 Carbon starvation protein CstA; Region: CstA; pfam02554 367737002366 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 367737002367 GTP-binding protein YchF; Reviewed; Region: PRK09601 367737002368 YchF GTPase; Region: YchF; cd01900 367737002369 G1 box; other site 367737002370 GTP/Mg2+ binding site [chemical binding]; other site 367737002371 Switch I region; other site 367737002372 G2 box; other site 367737002373 Switch II region; other site 367737002374 G3 box; other site 367737002375 G4 box; other site 367737002376 G5 box; other site 367737002377 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 367737002378 HDOD domain; Region: HDOD; pfam08668 367737002379 putative recombination protein RecO; Provisional; Region: PRK13908 367737002380 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 367737002381 NosL; Region: NosL; cl01769 367737002382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737002383 PAS domain; Region: PAS_9; pfam13426 367737002384 putative active site [active] 367737002385 heme pocket [chemical binding]; other site 367737002386 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737002387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737002388 metal binding site [ion binding]; metal-binding site 367737002389 active site 367737002390 I-site; other site 367737002391 thiamine monophosphate kinase; Provisional; Region: PRK05731 367737002392 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 367737002393 ATP binding site [chemical binding]; other site 367737002394 dimerization interface [polypeptide binding]; other site 367737002395 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 367737002396 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 367737002397 Permutation of conserved domain; other site 367737002398 active site 367737002399 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 367737002400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002401 dimer interface [polypeptide binding]; other site 367737002402 putative CheW interface [polypeptide binding]; other site 367737002403 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 367737002404 RuvA N terminal domain; Region: RuvA_N; pfam01330 367737002405 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 367737002406 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 367737002407 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367737002408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367737002409 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 367737002410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367737002411 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 367737002412 nucleotide binding site/active site [active] 367737002413 HIT family signature motif; other site 367737002414 catalytic residue [active] 367737002415 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 367737002416 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 367737002417 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 367737002418 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 367737002419 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 367737002420 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 367737002421 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 367737002422 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 367737002423 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 367737002424 putative translocon binding site; other site 367737002425 protein-rRNA interface [nucleotide binding]; other site 367737002426 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 367737002427 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 367737002428 G-X-X-G motif; other site 367737002429 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 367737002430 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 367737002431 23S rRNA interface [nucleotide binding]; other site 367737002432 5S rRNA interface [nucleotide binding]; other site 367737002433 putative antibiotic binding site [chemical binding]; other site 367737002434 L25 interface [polypeptide binding]; other site 367737002435 L27 interface [polypeptide binding]; other site 367737002436 50S ribosomal protein L29; Reviewed; Region: PRK00306 367737002437 trigger factor interaction site; other site 367737002438 23S rRNA interface [nucleotide binding]; other site 367737002439 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 367737002440 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 367737002441 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 367737002442 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 367737002443 RNA binding site [nucleotide binding]; other site 367737002444 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 367737002445 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 367737002446 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 367737002447 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 367737002448 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 367737002449 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 367737002450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 367737002451 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 367737002452 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 367737002453 5S rRNA interface [nucleotide binding]; other site 367737002454 L27 interface [polypeptide binding]; other site 367737002455 23S rRNA interface [nucleotide binding]; other site 367737002456 L5 interface [polypeptide binding]; other site 367737002457 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 367737002458 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 367737002459 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 367737002460 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 367737002461 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 367737002462 SecY translocase; Region: SecY; pfam00344 367737002463 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 367737002464 active site 367737002465 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 367737002466 rRNA binding site [nucleotide binding]; other site 367737002467 predicted 30S ribosome binding site; other site 367737002468 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 367737002469 Fe-S cluster binding site [ion binding]; other site 367737002470 active site 367737002471 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 367737002472 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 367737002473 dimer interface [polypeptide binding]; other site 367737002474 anticodon binding site; other site 367737002475 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 367737002476 homodimer interface [polypeptide binding]; other site 367737002477 motif 1; other site 367737002478 active site 367737002479 motif 2; other site 367737002480 GAD domain; Region: GAD; pfam02938 367737002481 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367737002482 active site 367737002483 motif 3; other site 367737002484 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 367737002485 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 367737002486 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 367737002487 adenylate kinase; Reviewed; Region: adk; PRK00279 367737002488 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 367737002489 AMP-binding site [chemical binding]; other site 367737002490 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 367737002491 adenylate kinase; Reviewed; Region: adk; PRK00279 367737002492 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 367737002493 AMP-binding site [chemical binding]; other site 367737002494 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 367737002495 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 367737002496 competence damage-inducible protein A; Provisional; Region: PRK01215 367737002497 MPT binding site; other site 367737002498 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 367737002499 Chloramphenicol acetyltransferase; Region: CAT; smart01059 367737002500 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 367737002501 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 367737002502 putative NAD(P) binding site [chemical binding]; other site 367737002503 putative substrate binding site [chemical binding]; other site 367737002504 catalytic Zn binding site [ion binding]; other site 367737002505 structural Zn binding site [ion binding]; other site 367737002506 dimer interface [polypeptide binding]; other site 367737002507 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 367737002508 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 367737002509 dimer interface [polypeptide binding]; other site 367737002510 active site 367737002511 metal binding site [ion binding]; metal-binding site 367737002512 Cache domain; Region: Cache_1; pfam02743 367737002513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737002514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002515 dimer interface [polypeptide binding]; other site 367737002516 putative CheW interface [polypeptide binding]; other site 367737002517 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 367737002518 alanine racemase; Reviewed; Region: alr; PRK00053 367737002519 active site 367737002520 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367737002521 dimer interface [polypeptide binding]; other site 367737002522 substrate binding site [chemical binding]; other site 367737002523 catalytic residues [active] 367737002524 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 367737002525 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 367737002526 GIY-YIG motif/motif A; other site 367737002527 active site 367737002528 catalytic site [active] 367737002529 putative DNA binding site [nucleotide binding]; other site 367737002530 metal binding site [ion binding]; metal-binding site 367737002531 UvrB/uvrC motif; Region: UVR; pfam02151 367737002532 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 367737002533 Cache domain; Region: Cache_1; pfam02743 367737002534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002535 dimer interface [polypeptide binding]; other site 367737002536 putative CheW interface [polypeptide binding]; other site 367737002537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002538 dimer interface [polypeptide binding]; other site 367737002539 putative CheW interface [polypeptide binding]; other site 367737002540 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 367737002541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002542 dimer interface [polypeptide binding]; other site 367737002543 putative CheW interface [polypeptide binding]; other site 367737002544 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 367737002545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002546 dimer interface [polypeptide binding]; other site 367737002547 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737002548 putative CheW interface [polypeptide binding]; other site 367737002549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002551 active site 367737002552 phosphorylation site [posttranslational modification] 367737002553 intermolecular recognition site; other site 367737002554 dimerization interface [polypeptide binding]; other site 367737002555 DNA binding site [nucleotide binding] 367737002556 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 367737002557 Response regulator receiver domain; Region: Response_reg; pfam00072 367737002558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002559 active site 367737002560 phosphorylation site [posttranslational modification] 367737002561 intermolecular recognition site; other site 367737002562 dimerization interface [polypeptide binding]; other site 367737002563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737002564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737002565 dimer interface [polypeptide binding]; other site 367737002566 phosphorylation site [posttranslational modification] 367737002567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737002568 ATP binding site [chemical binding]; other site 367737002569 Mg2+ binding site [ion binding]; other site 367737002570 G-X-G motif; other site 367737002571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737002572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737002573 dimer interface [polypeptide binding]; other site 367737002574 phosphorylation site [posttranslational modification] 367737002575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737002576 ATP binding site [chemical binding]; other site 367737002577 Mg2+ binding site [ion binding]; other site 367737002578 G-X-G motif; other site 367737002579 Response regulator receiver domain; Region: Response_reg; pfam00072 367737002580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002581 active site 367737002582 phosphorylation site [posttranslational modification] 367737002583 intermolecular recognition site; other site 367737002584 dimerization interface [polypeptide binding]; other site 367737002585 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 367737002586 nudix motif; other site 367737002587 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 367737002588 Protein of unknown function DUF86; Region: DUF86; cl01031 367737002589 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 367737002590 active site 367737002591 NTP binding site [chemical binding]; other site 367737002592 metal binding triad [ion binding]; metal-binding site 367737002593 antibiotic binding site [chemical binding]; other site 367737002594 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 367737002595 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 367737002596 putative ligand binding site [chemical binding]; other site 367737002597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 367737002598 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 367737002599 TM-ABC transporter signature motif; other site 367737002600 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 367737002601 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 367737002602 TM-ABC transporter signature motif; other site 367737002603 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 367737002604 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 367737002605 Walker A/P-loop; other site 367737002606 ATP binding site [chemical binding]; other site 367737002607 Q-loop/lid; other site 367737002608 ABC transporter signature motif; other site 367737002609 Walker B; other site 367737002610 D-loop; other site 367737002611 H-loop/switch region; other site 367737002612 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 367737002613 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 367737002614 Walker A/P-loop; other site 367737002615 ATP binding site [chemical binding]; other site 367737002616 Q-loop/lid; other site 367737002617 ABC transporter signature motif; other site 367737002618 Walker B; other site 367737002619 D-loop; other site 367737002620 H-loop/switch region; other site 367737002621 UreD urease accessory protein; Region: UreD; cl00530 367737002622 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 367737002623 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 367737002624 alpha-gamma subunit interface [polypeptide binding]; other site 367737002625 beta-gamma subunit interface [polypeptide binding]; other site 367737002626 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 367737002627 gamma-beta subunit interface [polypeptide binding]; other site 367737002628 alpha-beta subunit interface [polypeptide binding]; other site 367737002629 urease subunit alpha; Reviewed; Region: ureC; PRK13207 367737002630 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 367737002631 subunit interactions [polypeptide binding]; other site 367737002632 active site 367737002633 flap region; other site 367737002634 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 367737002635 dimer interface [polypeptide binding]; other site 367737002636 catalytic residues [active] 367737002637 UreF; Region: UreF; pfam01730 367737002638 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 367737002639 G1 box; other site 367737002640 GTP/Mg2+ binding site [chemical binding]; other site 367737002641 G2 box; other site 367737002642 Switch I region; other site 367737002643 G3 box; other site 367737002644 Switch II region; other site 367737002645 G4 box; other site 367737002646 G5 box; other site 367737002647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367737002648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367737002649 Bacterial transcriptional repressor; Region: TetR; pfam13972 367737002650 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 367737002651 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 367737002652 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737002653 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737002654 Outer membrane efflux protein; Region: OEP; pfam02321 367737002655 Outer membrane efflux protein; Region: OEP; pfam02321 367737002656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 367737002657 MarR family; Region: MarR_2; cl17246 367737002658 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 367737002659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737002660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737002661 metal binding site [ion binding]; metal-binding site 367737002662 active site 367737002663 I-site; other site 367737002664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367737002665 putative catalytic site [active] 367737002666 putative metal binding site [ion binding]; other site 367737002667 putative phosphate binding site [ion binding]; other site 367737002668 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367737002669 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 367737002670 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 367737002671 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 367737002672 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 367737002673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737002674 FeS/SAM binding site; other site 367737002675 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 367737002676 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 367737002677 ABC1 family; Region: ABC1; cl17513 367737002678 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 367737002679 substrate binding site [chemical binding]; other site 367737002680 activation loop (A-loop); other site 367737002681 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737002682 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 367737002683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002684 active site 367737002685 phosphorylation site [posttranslational modification] 367737002686 intermolecular recognition site; other site 367737002687 dimerization interface [polypeptide binding]; other site 367737002688 LytTr DNA-binding domain; Region: LytTR; smart00850 367737002689 Histidine kinase; Region: His_kinase; pfam06580 367737002690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367737002691 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 367737002692 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 367737002693 DNA photolyase; Region: DNA_photolyase; pfam00875 367737002694 Protein of unknown function (DUF523); Region: DUF523; pfam04463 367737002695 Uncharacterized conserved protein [Function unknown]; Region: COG3272 367737002696 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 367737002697 Predicted permeases [General function prediction only]; Region: COG0679 367737002698 Domain of unknown function (DUF386); Region: DUF386; cl01047 367737002699 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 367737002700 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 367737002701 active site 367737002702 dimer interface [polypeptide binding]; other site 367737002703 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 367737002704 dimer interface [polypeptide binding]; other site 367737002705 active site 367737002706 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 367737002707 active site 367737002708 tetramer interface; other site 367737002709 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 367737002710 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 367737002711 active site 367737002712 substrate binding site [chemical binding]; other site 367737002713 metal binding site [ion binding]; metal-binding site 367737002714 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737002715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737002716 dimer interface [polypeptide binding]; other site 367737002717 putative CheW interface [polypeptide binding]; other site 367737002718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737002719 PAS domain; Region: PAS_9; pfam13426 367737002720 putative active site [active] 367737002721 heme pocket [chemical binding]; other site 367737002722 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 367737002723 active site 1 [active] 367737002724 dimer interface [polypeptide binding]; other site 367737002725 hexamer interface [polypeptide binding]; other site 367737002726 active site 2 [active] 367737002727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 367737002728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 367737002729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 367737002730 dimerization interface [polypeptide binding]; other site 367737002731 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 367737002732 active site 367737002733 ribulose/triose binding site [chemical binding]; other site 367737002734 phosphate binding site [ion binding]; other site 367737002735 substrate (anthranilate) binding pocket [chemical binding]; other site 367737002736 product (indole) binding pocket [chemical binding]; other site 367737002737 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 367737002738 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 367737002739 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 367737002740 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 367737002741 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 367737002742 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 367737002743 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 367737002744 dimer interface [polypeptide binding]; other site 367737002745 PYR/PP interface [polypeptide binding]; other site 367737002746 TPP binding site [chemical binding]; other site 367737002747 substrate binding site [chemical binding]; other site 367737002748 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 367737002749 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 367737002750 TPP-binding site [chemical binding]; other site 367737002751 2-oxoglutarate-acceptor oxidoreductase subunit OorC; Reviewed; Region: oorC; PRK08441 367737002752 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 367737002753 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367737002754 active site 367737002755 catalytic site [active] 367737002756 substrate binding site [chemical binding]; other site 367737002757 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 367737002758 active site 367737002759 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 367737002760 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 367737002761 substrate binding site [chemical binding]; other site 367737002762 hexamer interface [polypeptide binding]; other site 367737002763 metal binding site [ion binding]; metal-binding site 367737002764 Phospholipase A1; Region: PLA1; pfam02253 367737002765 dimerization interface [polypeptide binding]; other site 367737002766 substrate binding site [chemical binding]; other site 367737002767 active site 367737002768 calcium binding site [ion binding]; other site 367737002769 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 367737002770 dimer interface [polypeptide binding]; other site 367737002771 ADP-ribose binding site [chemical binding]; other site 367737002772 active site 367737002773 nudix motif; other site 367737002774 metal binding site [ion binding]; metal-binding site 367737002775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 367737002776 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 367737002777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737002778 NAD(P) binding site [chemical binding]; other site 367737002779 active site 367737002780 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 367737002781 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 367737002782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737002783 active site 367737002784 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 367737002785 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367737002786 catalytic residue [active] 367737002787 RIP metalloprotease RseP; Region: TIGR00054 367737002788 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 367737002789 active site 367737002790 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 367737002791 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 367737002792 putative substrate binding region [chemical binding]; other site 367737002793 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 367737002794 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 367737002795 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 367737002796 putative NAD(P) binding site [chemical binding]; other site 367737002797 active site 367737002798 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 367737002799 dihydrodipicolinate synthase; Region: dapA; TIGR00674 367737002800 dimer interface [polypeptide binding]; other site 367737002801 active site 367737002802 catalytic residue [active] 367737002803 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 367737002804 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 367737002805 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 367737002806 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 367737002807 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 367737002808 quinone interaction residues [chemical binding]; other site 367737002809 active site 367737002810 catalytic residues [active] 367737002811 FMN binding site [chemical binding]; other site 367737002812 substrate binding site [chemical binding]; other site 367737002813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367737002814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737002815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737002816 Walker A/P-loop; other site 367737002817 ATP binding site [chemical binding]; other site 367737002818 Q-loop/lid; other site 367737002819 ABC transporter signature motif; other site 367737002820 Walker B; other site 367737002821 D-loop; other site 367737002822 H-loop/switch region; other site 367737002823 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 367737002824 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 367737002825 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367737002826 putative catalytic site [active] 367737002827 putative metal binding site [ion binding]; other site 367737002828 putative phosphate binding site [ion binding]; other site 367737002829 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 367737002830 metal binding site 2 [ion binding]; metal-binding site 367737002831 putative DNA binding helix; other site 367737002832 metal binding site 1 [ion binding]; metal-binding site 367737002833 dimer interface [polypeptide binding]; other site 367737002834 structural Zn2+ binding site [ion binding]; other site 367737002835 metal-binding heat shock protein; Provisional; Region: PRK00016 367737002836 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 367737002837 active site 2 [active] 367737002838 active site 1 [active] 367737002839 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 367737002840 catalytic triad [active] 367737002841 active site nucleophile [active] 367737002842 DNA repair protein RadA; Provisional; Region: PRK11823 367737002843 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 367737002844 Walker A motif/ATP binding site; other site 367737002845 ATP binding site [chemical binding]; other site 367737002846 Walker B motif; other site 367737002847 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 367737002848 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 367737002849 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 367737002850 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 367737002851 PAS domain S-box; Region: sensory_box; TIGR00229 367737002852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737002853 putative active site [active] 367737002854 heme pocket [chemical binding]; other site 367737002855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737002856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737002857 metal binding site [ion binding]; metal-binding site 367737002858 active site 367737002859 I-site; other site 367737002860 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737002861 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 367737002862 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 367737002863 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 367737002864 P loop; other site 367737002865 GTP binding site [chemical binding]; other site 367737002866 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 367737002867 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 367737002868 catalytic residues [active] 367737002869 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 367737002870 phosphodiesterase; Provisional; Region: PRK12704 367737002871 Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Region: TFIIA_gamma_N; cl03508 367737002872 TFIIA subunit interface [polypeptide binding]; other site 367737002873 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737002874 Zn2+ binding site [ion binding]; other site 367737002875 Mg2+ binding site [ion binding]; other site 367737002876 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 367737002877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 367737002878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 367737002879 YcfA-like protein; Region: YcfA; pfam07927 367737002880 short chain dehydrogenase; Provisional; Region: PRK05993 367737002881 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 367737002882 NADP binding site [chemical binding]; other site 367737002883 active site 367737002884 steroid binding site; other site 367737002885 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 367737002886 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 367737002887 Cytochrome c [Energy production and conversion]; Region: COG3258 367737002888 Cytochrome c; Region: Cytochrom_C; pfam00034 367737002889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737002891 active site 367737002892 phosphorylation site [posttranslational modification] 367737002893 intermolecular recognition site; other site 367737002894 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 367737002895 dimerization interface [polypeptide binding]; other site 367737002896 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737002897 DNA binding site [nucleotide binding] 367737002898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737002899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737002900 dimer interface [polypeptide binding]; other site 367737002901 phosphorylation site [posttranslational modification] 367737002902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737002903 ATP binding site [chemical binding]; other site 367737002904 Mg2+ binding site [ion binding]; other site 367737002905 G-X-G motif; other site 367737002906 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 367737002907 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 367737002908 dimerization interface [polypeptide binding]; other site 367737002909 active site 367737002910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737002911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737002912 metal binding site [ion binding]; metal-binding site 367737002913 active site 367737002914 I-site; other site 367737002915 Yqey-like protein; Region: YqeY; pfam09424 367737002916 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 367737002917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737002918 Walker A/P-loop; other site 367737002919 ATP binding site [chemical binding]; other site 367737002920 Q-loop/lid; other site 367737002921 ABC transporter signature motif; other site 367737002922 Walker B; other site 367737002923 D-loop; other site 367737002924 H-loop/switch region; other site 367737002925 ABC transporter; Region: ABC_tran_2; pfam12848 367737002926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737002927 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 367737002928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367737002929 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 367737002930 active site 367737002931 Zn binding site [ion binding]; other site 367737002932 Uncharacterized conserved protein [Function unknown]; Region: COG0397 367737002933 hypothetical protein; Validated; Region: PRK00029 367737002934 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 367737002935 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 367737002936 GMP synthase; Reviewed; Region: guaA; PRK00074 367737002937 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 367737002938 AMP/PPi binding site [chemical binding]; other site 367737002939 candidate oxyanion hole; other site 367737002940 catalytic triad [active] 367737002941 potential glutamine specificity residues [chemical binding]; other site 367737002942 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 367737002943 ATP Binding subdomain [chemical binding]; other site 367737002944 Ligand Binding sites [chemical binding]; other site 367737002945 Dimerization subdomain; other site 367737002946 L-aspartate oxidase; Provisional; Region: PRK06175 367737002947 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 367737002948 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 367737002949 Protein of unknown function (DUF721); Region: DUF721; cl02324 367737002950 Protein of unknown function DUF45; Region: DUF45; pfam01863 367737002951 aspartate aminotransferase; Provisional; Region: PRK05764 367737002952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737002953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737002954 homodimer interface [polypeptide binding]; other site 367737002955 catalytic residue [active] 367737002956 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 367737002957 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 367737002958 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 367737002959 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 367737002960 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 367737002961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737002962 Zn2+ binding site [ion binding]; other site 367737002963 Mg2+ binding site [ion binding]; other site 367737002964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737002965 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 367737002966 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 367737002967 cyclase homology domain; Region: CHD; cd07302 367737002968 nucleotidyl binding site; other site 367737002969 metal binding site [ion binding]; metal-binding site 367737002970 dimer interface [polypeptide binding]; other site 367737002971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 367737002972 Tetratricopeptide repeat; Region: TPR_16; pfam13432 367737002973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737002974 TPR motif; other site 367737002975 FecR protein; Region: FecR; pfam04773 367737002976 Acyltransferase family; Region: Acyl_transf_3; pfam01757 367737002977 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 367737002978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737002979 S-adenosylmethionine binding site [chemical binding]; other site 367737002980 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 367737002981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737002982 putative substrate translocation pore; other site 367737002983 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 367737002984 cobalt transport protein CbiM; Validated; Region: PRK06265 367737002985 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 367737002986 Cobalt transport protein; Region: CbiQ; cl00463 367737002987 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367737002988 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 367737002989 Walker A/P-loop; other site 367737002990 ATP binding site [chemical binding]; other site 367737002991 Q-loop/lid; other site 367737002992 ABC transporter signature motif; other site 367737002993 Walker B; other site 367737002994 D-loop; other site 367737002995 H-loop/switch region; other site 367737002996 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 367737002997 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 367737002998 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 367737002999 haemagglutination activity domain; Region: Haemagg_act; pfam05860 367737003000 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 367737003001 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 367737003002 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 367737003003 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 367737003004 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 367737003005 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 367737003006 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 367737003007 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 367737003008 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 367737003009 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 367737003010 Domain of unknown function DUF20; Region: UPF0118; pfam01594 367737003011 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 367737003012 Domain of unknown function DUF87; Region: DUF87; pfam01935 367737003013 Zonular occludens toxin (Zot); Region: Zot; cl17485 367737003014 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 367737003015 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 367737003016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 367737003017 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 367737003018 PAS fold; Region: PAS; pfam00989 367737003019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737003020 putative active site [active] 367737003021 heme pocket [chemical binding]; other site 367737003022 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 367737003023 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 367737003024 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367737003025 serine O-acetyltransferase; Region: cysE; TIGR01172 367737003026 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 367737003027 trimer interface [polypeptide binding]; other site 367737003028 active site 367737003029 substrate binding site [chemical binding]; other site 367737003030 CoA binding site [chemical binding]; other site 367737003031 arginine decarboxylase; Provisional; Region: PRK05354 367737003032 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 367737003033 dimer interface [polypeptide binding]; other site 367737003034 active site 367737003035 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367737003036 catalytic residues [active] 367737003037 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 367737003038 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 367737003039 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 367737003040 dimer interface [polypeptide binding]; other site 367737003041 motif 1; other site 367737003042 active site 367737003043 motif 2; other site 367737003044 motif 3; other site 367737003045 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 367737003046 anticodon binding site; other site 367737003047 thymidylate kinase; Validated; Region: tmk; PRK00698 367737003048 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 367737003049 TMP-binding site; other site 367737003050 ATP-binding site [chemical binding]; other site 367737003051 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 367737003052 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 367737003053 active site 367737003054 (T/H)XGH motif; other site 367737003055 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 367737003056 Flavoprotein; Region: Flavoprotein; pfam02441 367737003057 multiple promoter invertase; Provisional; Region: mpi; PRK13413 367737003058 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 367737003059 catalytic residues [active] 367737003060 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 367737003061 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 367737003062 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 367737003063 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 367737003064 active site 367737003065 HslU subunit interaction site [polypeptide binding]; other site 367737003066 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 367737003067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737003068 Walker A motif; other site 367737003069 ATP binding site [chemical binding]; other site 367737003070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737003071 Walker B motif; other site 367737003072 arginine finger; other site 367737003073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 367737003074 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 367737003075 active site 367737003076 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 367737003077 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 367737003078 N-acetyl-D-glucosamine binding site [chemical binding]; other site 367737003079 catalytic residue [active] 367737003080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 367737003081 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 367737003082 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 367737003083 Sporulation related domain; Region: SPOR; pfam05036 367737003084 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 367737003085 putative active site pocket [active] 367737003086 4-fold oligomerization interface [polypeptide binding]; other site 367737003087 metal binding residues [ion binding]; metal-binding site 367737003088 3-fold/trimer interface [polypeptide binding]; other site 367737003089 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 367737003090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737003091 active site 367737003092 motif I; other site 367737003093 motif II; other site 367737003094 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 367737003095 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 367737003096 OstA-like protein; Region: OstA; pfam03968 367737003097 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 367737003098 G1 box; other site 367737003099 GTP/Mg2+ binding site [chemical binding]; other site 367737003100 Switch I region; other site 367737003101 G2 box; other site 367737003102 G3 box; other site 367737003103 Switch II region; other site 367737003104 G4 box; other site 367737003105 G5 box; other site 367737003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367737003107 Coenzyme A binding pocket [chemical binding]; other site 367737003108 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 367737003109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737003110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737003111 DNA binding residues [nucleotide binding] 367737003112 FecR protein; Region: FecR; pfam04773 367737003113 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737003114 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737003115 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737003116 N-terminal plug; other site 367737003117 ligand-binding site [chemical binding]; other site 367737003118 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 367737003119 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 367737003120 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 367737003121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 367737003122 DNA-binding site [nucleotide binding]; DNA binding site 367737003123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737003124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737003125 homodimer interface [polypeptide binding]; other site 367737003126 catalytic residue [active] 367737003127 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 367737003128 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 367737003129 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 367737003130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737003131 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737003132 Outer membrane efflux protein; Region: OEP; pfam02321 367737003133 Outer membrane efflux protein; Region: OEP; pfam02321 367737003134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737003135 PAS domain; Region: PAS_9; pfam13426 367737003136 putative active site [active] 367737003137 heme pocket [chemical binding]; other site 367737003138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737003139 Zn2+ binding site [ion binding]; other site 367737003140 Mg2+ binding site [ion binding]; other site 367737003141 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 367737003142 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 367737003143 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 367737003144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 367737003145 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 367737003146 Peptidase family M23; Region: Peptidase_M23; pfam01551 367737003147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737003148 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367737003149 Walker A/P-loop; other site 367737003150 ATP binding site [chemical binding]; other site 367737003151 Q-loop/lid; other site 367737003152 ABC transporter signature motif; other site 367737003153 Walker B; other site 367737003154 D-loop; other site 367737003155 H-loop/switch region; other site 367737003156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003157 S-adenosylmethionine binding site [chemical binding]; other site 367737003158 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 367737003159 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 367737003160 Interdomain contacts; other site 367737003161 Cytokine receptor motif; other site 367737003162 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 367737003163 Interdomain contacts; other site 367737003164 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 367737003165 Interdomain contacts; other site 367737003166 Cytokine receptor motif; other site 367737003167 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 367737003168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737003169 RNA binding surface [nucleotide binding]; other site 367737003170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 367737003171 active site 367737003172 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 367737003173 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 367737003174 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 367737003175 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 367737003176 inhibitor-cofactor binding pocket; inhibition site 367737003177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737003178 catalytic residue [active] 367737003179 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 367737003180 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 367737003181 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 367737003182 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 367737003183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737003184 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 367737003185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737003186 DNA binding residues [nucleotide binding] 367737003187 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 367737003188 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 367737003189 substrate binding site [chemical binding]; other site 367737003190 tartrate dehydrogenase; Region: TTC; TIGR02089 367737003191 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 367737003192 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 367737003193 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 367737003194 HIT family signature motif; other site 367737003195 catalytic residue [active] 367737003196 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 367737003197 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 367737003198 30S ribosomal protein S13; Region: bact_S13; TIGR03631 367737003199 30S ribosomal protein S11; Validated; Region: PRK05309 367737003200 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 367737003201 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 367737003202 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737003203 RNA binding surface [nucleotide binding]; other site 367737003204 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 367737003205 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 367737003206 alphaNTD homodimer interface [polypeptide binding]; other site 367737003207 alphaNTD - beta interaction site [polypeptide binding]; other site 367737003208 alphaNTD - beta' interaction site [polypeptide binding]; other site 367737003209 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 367737003210 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 367737003211 indole-3-acetamide amidohydrolase; Region: PLN02722 367737003212 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 367737003213 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 367737003214 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 367737003215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 367737003216 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 367737003217 active site 367737003218 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 367737003219 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367737003220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367737003221 substrate binding pocket [chemical binding]; other site 367737003222 membrane-bound complex binding site; other site 367737003223 hinge residues; other site 367737003224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003227 active site 367737003228 phosphorylation site [posttranslational modification] 367737003229 intermolecular recognition site; other site 367737003230 dimerization interface [polypeptide binding]; other site 367737003231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 367737003232 DNA binding site [nucleotide binding] 367737003233 Outer membrane efflux protein; Region: OEP; pfam02321 367737003234 Outer membrane efflux protein; Region: OEP; pfam02321 367737003235 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737003236 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737003237 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 367737003238 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 367737003239 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 367737003240 Ca2+ binding site [ion binding]; other site 367737003241 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 367737003242 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737003243 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737003244 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 367737003245 Peptidase family M50; Region: Peptidase_M50; pfam02163 367737003246 active site 367737003247 putative substrate binding region [chemical binding]; other site 367737003248 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 367737003249 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737003250 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367737003251 HSP70 interaction site [polypeptide binding]; other site 367737003252 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367737003253 HSP70 interaction site [polypeptide binding]; other site 367737003254 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 367737003255 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 367737003256 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 367737003257 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 367737003258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003260 ATP binding site [chemical binding]; other site 367737003261 Mg2+ binding site [ion binding]; other site 367737003262 G-X-G motif; other site 367737003263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003265 active site 367737003266 phosphorylation site [posttranslational modification] 367737003267 intermolecular recognition site; other site 367737003268 dimerization interface [polypeptide binding]; other site 367737003269 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737003270 DNA binding site [nucleotide binding] 367737003271 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 367737003272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003273 Walker A/P-loop; other site 367737003274 ATP binding site [chemical binding]; other site 367737003275 Q-loop/lid; other site 367737003276 ABC transporter signature motif; other site 367737003277 Walker B; other site 367737003278 D-loop; other site 367737003279 H-loop/switch region; other site 367737003280 RNA polymerase sigma factor; Reviewed; Region: PRK12527 367737003281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737003282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737003283 DNA binding residues [nucleotide binding] 367737003284 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737003285 FecR protein; Region: FecR; pfam04773 367737003286 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 367737003287 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 367737003288 tetramer interface [polypeptide binding]; other site 367737003289 catalytic Zn binding site [ion binding]; other site 367737003290 NADP binding site [chemical binding]; other site 367737003291 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367737003292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 367737003293 ligand binding site [chemical binding]; other site 367737003294 flexible hinge region; other site 367737003295 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367737003296 EamA-like transporter family; Region: EamA; pfam00892 367737003297 EamA-like transporter family; Region: EamA; pfam00892 367737003298 Predicted transcriptional regulators [Transcription]; Region: COG1733 367737003299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367737003300 dimerization interface [polypeptide binding]; other site 367737003301 putative DNA binding site [nucleotide binding]; other site 367737003302 putative Zn2+ binding site [ion binding]; other site 367737003303 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 367737003304 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 367737003305 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 367737003306 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 367737003307 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 367737003308 EamA-like transporter family; Region: EamA; pfam00892 367737003309 EamA-like transporter family; Region: EamA; pfam00892 367737003310 Helix-turn-helix domain; Region: HTH_18; pfam12833 367737003311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737003312 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 367737003313 substrate binding site [chemical binding]; other site 367737003314 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 367737003315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 367737003316 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 367737003317 putative dimerization interface [polypeptide binding]; other site 367737003318 Predicted membrane protein [Function unknown]; Region: COG2855 367737003319 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 367737003320 dimerization domain [polypeptide binding]; other site 367737003321 dimer interface [polypeptide binding]; other site 367737003322 catalytic residues [active] 367737003323 Membrane transport protein; Region: Mem_trans; cl09117 367737003324 Predicted transcriptional regulators [Transcription]; Region: COG1733 367737003325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367737003326 dimerization interface [polypeptide binding]; other site 367737003327 putative DNA binding site [nucleotide binding]; other site 367737003328 putative Zn2+ binding site [ion binding]; other site 367737003329 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 367737003330 Uncharacterized conserved protein [Function unknown]; Region: COG1359 367737003331 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 367737003332 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 367737003333 active site 367737003334 FMN binding site [chemical binding]; other site 367737003335 substrate binding site [chemical binding]; other site 367737003336 homotetramer interface [polypeptide binding]; other site 367737003337 catalytic residue [active] 367737003338 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367737003339 EamA-like transporter family; Region: EamA; pfam00892 367737003340 EamA-like transporter family; Region: EamA; pfam00892 367737003341 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 367737003342 dimer interface [polypeptide binding]; other site 367737003343 FMN binding site [chemical binding]; other site 367737003344 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 367737003345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003346 Walker A/P-loop; other site 367737003347 ATP binding site [chemical binding]; other site 367737003348 Q-loop/lid; other site 367737003349 ABC transporter signature motif; other site 367737003350 Walker B; other site 367737003351 D-loop; other site 367737003352 H-loop/switch region; other site 367737003353 ABC transporter; Region: ABC_tran_2; pfam12848 367737003354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737003355 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 367737003356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737003357 dimer interface [polypeptide binding]; other site 367737003358 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737003359 putative CheW interface [polypeptide binding]; other site 367737003360 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 367737003361 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 367737003362 nucleotide binding pocket [chemical binding]; other site 367737003363 K-X-D-G motif; other site 367737003364 catalytic site [active] 367737003365 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 367737003366 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 367737003367 Dimer interface [polypeptide binding]; other site 367737003368 BRCT sequence motif; other site 367737003369 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 367737003370 hypothetical protein; Provisional; Region: PRK04081 367737003371 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 367737003372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 367737003373 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 367737003374 Fic family protein [Function unknown]; Region: COG3177 367737003375 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 367737003376 Fic/DOC family; Region: Fic; pfam02661 367737003377 putative DNA binding site [nucleotide binding]; other site 367737003378 putative Zn2+ binding site [ion binding]; other site 367737003379 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 367737003380 Fic family protein [Function unknown]; Region: COG3177 367737003381 Fic/DOC family; Region: Fic; pfam02661 367737003382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367737003383 dimerization interface [polypeptide binding]; other site 367737003384 putative DNA binding site [nucleotide binding]; other site 367737003385 putative Zn2+ binding site [ion binding]; other site 367737003386 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 367737003387 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 367737003388 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 367737003389 shikimate binding site; other site 367737003390 NAD(P) binding site [chemical binding]; other site 367737003391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003392 S-adenosylmethionine binding site [chemical binding]; other site 367737003393 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 367737003394 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 367737003395 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 367737003396 Malic enzyme, N-terminal domain; Region: malic; pfam00390 367737003397 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 367737003398 putative NAD(P) binding site [chemical binding]; other site 367737003399 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 367737003400 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 367737003401 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 367737003402 putative active site [active] 367737003403 putative substrate binding site [chemical binding]; other site 367737003404 putative cosubstrate binding site; other site 367737003405 catalytic site [active] 367737003406 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 367737003407 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 367737003408 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 367737003409 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 367737003410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003412 active site 367737003413 phosphorylation site [posttranslational modification] 367737003414 intermolecular recognition site; other site 367737003415 dimerization interface [polypeptide binding]; other site 367737003416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737003417 DNA binding site [nucleotide binding] 367737003418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737003420 phosphorylation site [posttranslational modification] 367737003421 dimer interface [polypeptide binding]; other site 367737003422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003423 ATP binding site [chemical binding]; other site 367737003424 Mg2+ binding site [ion binding]; other site 367737003425 G-X-G motif; other site 367737003426 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 367737003427 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 367737003428 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 367737003429 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 367737003430 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 367737003431 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 367737003432 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 367737003433 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 367737003434 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 367737003435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737003436 TPR motif; other site 367737003437 TPR repeat; Region: TPR_11; pfam13414 367737003438 binding surface 367737003439 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 367737003440 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 367737003441 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 367737003442 active site 367737003443 uracil binding [chemical binding]; other site 367737003444 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 367737003445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737003446 motif II; other site 367737003447 Family description; Region: DsbD_2; pfam13386 367737003448 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737003449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737003450 N-terminal plug; other site 367737003451 ligand-binding site [chemical binding]; other site 367737003452 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 367737003453 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 367737003454 intersubunit interface [polypeptide binding]; other site 367737003455 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 367737003456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003457 Walker A/P-loop; other site 367737003458 ATP binding site [chemical binding]; other site 367737003459 Q-loop/lid; other site 367737003460 ABC transporter signature motif; other site 367737003461 Walker B; other site 367737003462 D-loop; other site 367737003463 H-loop/switch region; other site 367737003464 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 367737003465 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 367737003466 ABC-ATPase subunit interface; other site 367737003467 dimer interface [polypeptide binding]; other site 367737003468 putative PBP binding regions; other site 367737003469 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367737003470 catalytic core [active] 367737003471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367737003472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737003473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003474 Walker A/P-loop; other site 367737003475 ATP binding site [chemical binding]; other site 367737003476 Q-loop/lid; other site 367737003477 ABC transporter signature motif; other site 367737003478 Walker B; other site 367737003479 D-loop; other site 367737003480 H-loop/switch region; other site 367737003481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003483 active site 367737003484 phosphorylation site [posttranslational modification] 367737003485 intermolecular recognition site; other site 367737003486 dimerization interface [polypeptide binding]; other site 367737003487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737003488 DNA binding site [nucleotide binding] 367737003489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737003491 dimer interface [polypeptide binding]; other site 367737003492 phosphorylation site [posttranslational modification] 367737003493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003494 ATP binding site [chemical binding]; other site 367737003495 Mg2+ binding site [ion binding]; other site 367737003496 G-X-G motif; other site 367737003497 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 367737003498 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 367737003499 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 367737003500 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367737003501 active site 367737003502 catalytic site [active] 367737003503 substrate binding site [chemical binding]; other site 367737003504 diguanylate cyclase; Provisional; Region: PRK09894 367737003505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737003506 metal binding site [ion binding]; metal-binding site 367737003507 active site 367737003508 I-site; other site 367737003509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367737003510 non-specific DNA binding site [nucleotide binding]; other site 367737003511 salt bridge; other site 367737003512 sequence-specific DNA binding site [nucleotide binding]; other site 367737003513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 367737003514 putative Mg++ binding site [ion binding]; other site 367737003515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737003516 nucleotide binding region [chemical binding]; other site 367737003517 ATP-binding site [chemical binding]; other site 367737003518 PAS domain S-box; Region: sensory_box; TIGR00229 367737003519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003521 ATP binding site [chemical binding]; other site 367737003522 Mg2+ binding site [ion binding]; other site 367737003523 G-X-G motif; other site 367737003524 Response regulator receiver domain; Region: Response_reg; pfam00072 367737003525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003526 active site 367737003527 phosphorylation site [posttranslational modification] 367737003528 intermolecular recognition site; other site 367737003529 dimerization interface [polypeptide binding]; other site 367737003530 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737003531 DNA binding site [nucleotide binding] 367737003532 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 367737003533 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737003534 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737003535 ligand binding site [chemical binding]; other site 367737003536 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 367737003537 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 367737003538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367737003539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003540 Walker A/P-loop; other site 367737003541 ATP binding site [chemical binding]; other site 367737003542 Q-loop/lid; other site 367737003543 ABC transporter signature motif; other site 367737003544 Walker B; other site 367737003545 D-loop; other site 367737003546 H-loop/switch region; other site 367737003547 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 367737003548 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 367737003549 E3 interaction surface; other site 367737003550 lipoyl attachment site [posttranslational modification]; other site 367737003551 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737003552 two component system sensor kinase SsrB; Provisional; Region: PRK15369 367737003553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367737003554 DNA binding residues [nucleotide binding] 367737003555 dimerization interface [polypeptide binding]; other site 367737003556 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 367737003557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737003558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737003559 metal binding site [ion binding]; metal-binding site 367737003560 active site 367737003561 I-site; other site 367737003562 EAL domain; Region: EAL; pfam00563 367737003563 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 367737003564 active site 367737003565 dimer interface [polypeptide binding]; other site 367737003566 metal binding site [ion binding]; metal-binding site 367737003567 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 367737003568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 367737003569 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 367737003570 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 367737003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737003572 FeS/SAM binding site; other site 367737003573 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 367737003574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737003575 Walker B motif; other site 367737003576 arginine finger; other site 367737003577 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 367737003578 MPT binding site; other site 367737003579 trimer interface [polypeptide binding]; other site 367737003580 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 367737003581 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 367737003582 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367737003583 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367737003584 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367737003585 catalytic core [active] 367737003586 DNA polymerase III PolC; Validated; Region: polC; PRK00448 367737003587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 367737003588 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 367737003589 dimer interface [polypeptide binding]; other site 367737003590 ligand binding site [chemical binding]; other site 367737003591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367737003592 non-specific DNA binding site [nucleotide binding]; other site 367737003593 salt bridge; other site 367737003594 sequence-specific DNA binding site [nucleotide binding]; other site 367737003595 AAA domain; Region: AAA_33; pfam13671 367737003596 AAA domain; Region: AAA_17; pfam13207 367737003597 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 367737003598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737003599 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 367737003600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737003601 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 367737003602 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 367737003603 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 367737003604 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 367737003605 molybdopterin cofactor binding site [chemical binding]; other site 367737003606 substrate binding site [chemical binding]; other site 367737003607 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 367737003608 molybdopterin cofactor binding site; other site 367737003609 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 367737003610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367737003611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367737003612 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 367737003613 MutS domain III; Region: MutS_III; cl17822 367737003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737003615 Walker A/P-loop; other site 367737003616 ATP binding site [chemical binding]; other site 367737003617 Q-loop/lid; other site 367737003618 ABC transporter signature motif; other site 367737003619 Walker B; other site 367737003620 D-loop; other site 367737003621 H-loop/switch region; other site 367737003622 Smr domain; Region: Smr; pfam01713 367737003623 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 367737003624 Domain of unknown function DUF21; Region: DUF21; pfam01595 367737003625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 367737003626 Transporter associated domain; Region: CorC_HlyC; smart01091 367737003627 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 367737003628 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 367737003629 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 367737003630 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 367737003631 metal binding site [ion binding]; metal-binding site 367737003632 dimer interface [polypeptide binding]; other site 367737003633 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 367737003634 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 367737003635 Nitrogen regulatory protein P-II; Region: P-II; smart00938 367737003636 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 367737003637 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 367737003638 exopolyphosphatase; Region: exo_poly_only; TIGR03706 367737003639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367737003640 nucleotide binding site [chemical binding]; other site 367737003641 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 367737003642 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 367737003643 PYR/PP interface [polypeptide binding]; other site 367737003644 dimer interface [polypeptide binding]; other site 367737003645 TPP binding site [chemical binding]; other site 367737003646 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 367737003647 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 367737003648 TPP-binding site [chemical binding]; other site 367737003649 dimer interface [polypeptide binding]; other site 367737003650 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 367737003651 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 367737003652 putative valine binding site [chemical binding]; other site 367737003653 dimer interface [polypeptide binding]; other site 367737003654 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 367737003655 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 367737003656 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 367737003657 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 367737003658 trimer interface [polypeptide binding]; other site 367737003659 active site 367737003660 UDP-GlcNAc binding site [chemical binding]; other site 367737003661 lipid binding site [chemical binding]; lipid-binding site 367737003662 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 367737003663 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 367737003664 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 367737003665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003667 active site 367737003668 phosphorylation site [posttranslational modification] 367737003669 intermolecular recognition site; other site 367737003670 dimerization interface [polypeptide binding]; other site 367737003671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737003672 DNA binding site [nucleotide binding] 367737003673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003674 HAMP domain; Region: HAMP; pfam00672 367737003675 dimerization interface [polypeptide binding]; other site 367737003676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003677 ATP binding site [chemical binding]; other site 367737003678 Mg2+ binding site [ion binding]; other site 367737003679 G-X-G motif; other site 367737003680 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 367737003681 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 367737003682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 367737003683 Histidine kinase; Region: HisKA_2; pfam07568 367737003684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003685 ATP binding site [chemical binding]; other site 367737003686 Mg2+ binding site [ion binding]; other site 367737003687 G-X-G motif; other site 367737003688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003690 active site 367737003691 phosphorylation site [posttranslational modification] 367737003692 intermolecular recognition site; other site 367737003693 dimerization interface [polypeptide binding]; other site 367737003694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737003695 DNA binding site [nucleotide binding] 367737003696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003698 active site 367737003699 phosphorylation site [posttranslational modification] 367737003700 intermolecular recognition site; other site 367737003701 dimerization interface [polypeptide binding]; other site 367737003702 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737003703 DNA binding site [nucleotide binding] 367737003704 SEC-C motif; Region: SEC-C; pfam02810 367737003705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 367737003706 exonuclease SbcD; Region: sbcd; TIGR00619 367737003707 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 367737003708 Part of AAA domain; Region: AAA_19; pfam13245 367737003709 AAA domain; Region: AAA_12; pfam13087 367737003710 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 367737003711 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 367737003712 30S subunit binding site; other site 367737003713 GTP-binding protein Der; Reviewed; Region: PRK00093 367737003714 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 367737003715 G1 box; other site 367737003716 GTP/Mg2+ binding site [chemical binding]; other site 367737003717 Switch I region; other site 367737003718 G2 box; other site 367737003719 Switch II region; other site 367737003720 G3 box; other site 367737003721 G4 box; other site 367737003722 G5 box; other site 367737003723 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 367737003724 G1 box; other site 367737003725 GTP/Mg2+ binding site [chemical binding]; other site 367737003726 Switch I region; other site 367737003727 G2 box; other site 367737003728 G3 box; other site 367737003729 Switch II region; other site 367737003730 G4 box; other site 367737003731 G5 box; other site 367737003732 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 367737003733 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 367737003734 Sulfate transporter family; Region: Sulfate_transp; pfam00916 367737003735 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 367737003736 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 367737003737 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 367737003738 active site 367737003739 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 367737003740 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 367737003741 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 367737003742 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 367737003743 RDD family; Region: RDD; pfam06271 367737003744 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 367737003745 Organic solvent tolerance protein; Region: OstA_C; pfam04453 367737003746 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737003747 active site 367737003748 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 367737003749 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 367737003750 oligomer interface [polypeptide binding]; other site 367737003751 RNA binding site [nucleotide binding]; other site 367737003752 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 367737003753 RNase E interface [polypeptide binding]; other site 367737003754 trimer interface [polypeptide binding]; other site 367737003755 active site 367737003756 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 367737003757 putative nucleic acid binding region [nucleotide binding]; other site 367737003758 G-X-X-G motif; other site 367737003759 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 367737003760 RNA binding site [nucleotide binding]; other site 367737003761 Response regulator receiver domain; Region: Response_reg; pfam00072 367737003762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003763 active site 367737003764 phosphorylation site [posttranslational modification] 367737003765 intermolecular recognition site; other site 367737003766 dimerization interface [polypeptide binding]; other site 367737003767 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 367737003768 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 367737003769 putative binding surface; other site 367737003770 active site 367737003771 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 367737003772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003773 ATP binding site [chemical binding]; other site 367737003774 Mg2+ binding site [ion binding]; other site 367737003775 G-X-G motif; other site 367737003776 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 367737003777 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 367737003778 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 367737003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003780 CheD chemotactic sensory transduction; Region: CheD; cl00810 367737003781 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 367737003782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003783 active site 367737003784 phosphorylation site [posttranslational modification] 367737003785 intermolecular recognition site; other site 367737003786 dimerization interface [polypeptide binding]; other site 367737003787 CheB methylesterase; Region: CheB_methylest; pfam01339 367737003788 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 367737003789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737003790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737003791 putative substrate translocation pore; other site 367737003792 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 367737003793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 367737003794 active site 367737003795 DNA binding site [nucleotide binding] 367737003796 Int/Topo IB signature motif; other site 367737003797 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 367737003798 putative active site [active] 367737003799 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 367737003800 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 367737003801 active site 367737003802 Zn binding site [ion binding]; other site 367737003803 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 367737003804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003805 S-adenosylmethionine binding site [chemical binding]; other site 367737003806 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 367737003807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737003808 FeS/SAM binding site; other site 367737003809 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 367737003810 putative active site [active] 367737003811 Ap4A binding site [chemical binding]; other site 367737003812 nudix motif; other site 367737003813 putative metal binding site [ion binding]; other site 367737003814 aspartate kinase; Reviewed; Region: PRK06635 367737003815 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 367737003816 putative nucleotide binding site [chemical binding]; other site 367737003817 putative catalytic residues [active] 367737003818 putative Mg ion binding site [ion binding]; other site 367737003819 putative aspartate binding site [chemical binding]; other site 367737003820 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 367737003821 putative allosteric regulatory site; other site 367737003822 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 367737003823 DNA replication regulator; Region: HobA; pfam12163 367737003824 DNA polymerase III subunit delta'; Validated; Region: PRK08485 367737003825 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 367737003826 dihydropteroate synthase; Region: DHPS; TIGR01496 367737003827 substrate binding pocket [chemical binding]; other site 367737003828 dimer interface [polypeptide binding]; other site 367737003829 inhibitor binding site; inhibition site 367737003830 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 367737003831 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 367737003832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003833 S-adenosylmethionine binding site [chemical binding]; other site 367737003834 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 367737003835 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 367737003836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367737003837 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 367737003838 MFS/sugar transport protein; Region: MFS_2; pfam13347 367737003839 MFS/sugar transport protein; Region: MFS_2; pfam13347 367737003840 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 367737003841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737003842 NAD(P) binding site [chemical binding]; other site 367737003843 active site 367737003844 prephenate dehydrogenase; Validated; Region: PRK08507 367737003845 Prephenate dehydrogenase; Region: PDH; pfam02153 367737003846 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 367737003847 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 367737003848 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 367737003849 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 367737003850 Surface antigen; Region: Bac_surface_Ag; pfam01103 367737003851 hypothetical protein; Provisional; Region: PRK08445 367737003852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737003853 FeS/SAM binding site; other site 367737003854 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 367737003855 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 367737003856 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 367737003857 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 367737003858 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367737003859 active site 367737003860 HIGH motif; other site 367737003861 nucleotide binding site [chemical binding]; other site 367737003862 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 367737003863 active site 367737003864 KMSKS motif; other site 367737003865 YGGT family; Region: YGGT; pfam02325 367737003866 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 367737003867 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 367737003868 N-acetyl-D-glucosamine binding site [chemical binding]; other site 367737003869 catalytic residue [active] 367737003870 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 367737003871 Walker A motif; other site 367737003872 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 367737003873 AMP binding site [chemical binding]; other site 367737003874 metal binding site [ion binding]; metal-binding site 367737003875 active site 367737003876 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 367737003877 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 367737003878 active site 367737003879 HIGH motif; other site 367737003880 KMSKS motif; other site 367737003881 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 367737003882 anticodon binding site; other site 367737003883 tRNA binding surface [nucleotide binding]; other site 367737003884 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 367737003885 dimer interface [polypeptide binding]; other site 367737003886 putative tRNA-binding site [nucleotide binding]; other site 367737003887 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 367737003888 Predicted transcriptional regulator [Transcription]; Region: COG2932 367737003889 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 367737003890 Catalytic site [active] 367737003891 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 367737003892 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 367737003893 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 367737003894 active site 367737003895 catalytic residues [active] 367737003896 metal binding site [ion binding]; metal-binding site 367737003897 homodimer binding site [polypeptide binding]; other site 367737003898 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 367737003899 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 367737003900 carboxyltransferase (CT) interaction site; other site 367737003901 biotinylation site [posttranslational modification]; other site 367737003902 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 367737003903 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 367737003904 active site 367737003905 substrate-binding site [chemical binding]; other site 367737003906 metal-binding site [ion binding] 367737003907 ATP binding site [chemical binding]; other site 367737003908 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 367737003909 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 367737003910 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 367737003911 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 367737003912 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 367737003913 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 367737003914 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 367737003915 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 367737003916 dimerization interface [polypeptide binding]; other site 367737003917 active site 367737003918 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 367737003919 dimer interface [polypeptide binding]; other site 367737003920 active site 367737003921 Schiff base residues; other site 367737003922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737003923 PAS domain; Region: PAS_9; pfam13426 367737003924 putative active site [active] 367737003925 heme pocket [chemical binding]; other site 367737003926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737003927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737003928 ATP binding site [chemical binding]; other site 367737003929 Mg2+ binding site [ion binding]; other site 367737003930 G-X-G motif; other site 367737003931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737003932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737003933 active site 367737003934 phosphorylation site [posttranslational modification] 367737003935 intermolecular recognition site; other site 367737003936 dimerization interface [polypeptide binding]; other site 367737003937 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737003938 DNA binding site [nucleotide binding] 367737003939 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 367737003940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737003941 FeS/SAM binding site; other site 367737003942 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 367737003943 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 367737003944 ATP cone domain; Region: ATP-cone; pfam03477 367737003945 Class III ribonucleotide reductase; Region: RNR_III; cd01675 367737003946 effector binding site; other site 367737003947 active site 367737003948 Zn binding site [ion binding]; other site 367737003949 ornithine carbamoyltransferase; Provisional; Region: PRK00779 367737003950 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 367737003951 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 367737003952 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 367737003953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737003954 FeS/SAM binding site; other site 367737003955 HemN C-terminal domain; Region: HemN_C; pfam06969 367737003956 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 367737003957 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 367737003958 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 367737003959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367737003960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737003961 catalytic residue [active] 367737003962 NAD synthetase; Provisional; Region: PRK13980 367737003963 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 367737003964 homodimer interface [polypeptide binding]; other site 367737003965 NAD binding pocket [chemical binding]; other site 367737003966 ATP binding pocket [chemical binding]; other site 367737003967 Mg binding site [ion binding]; other site 367737003968 active-site loop [active] 367737003969 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 367737003970 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 367737003971 putative metal binding site [ion binding]; other site 367737003972 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367737003973 HSP70 interaction site [polypeptide binding]; other site 367737003974 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 367737003975 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 367737003976 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 367737003977 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 367737003978 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 367737003979 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367737003980 active site 367737003981 catalytic site [active] 367737003982 substrate binding site [chemical binding]; other site 367737003983 Competence protein; Region: Competence; pfam03772 367737003984 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 367737003985 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 367737003986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737003987 S-adenosylmethionine binding site [chemical binding]; other site 367737003988 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 367737003989 putative active site pocket [active] 367737003990 dimerization interface [polypeptide binding]; other site 367737003991 putative catalytic residue [active] 367737003992 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 367737003993 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 367737003994 Cysteine-rich domain; Region: CCG; pfam02754 367737003995 Cysteine-rich domain; Region: CCG; pfam02754 367737003996 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 367737003997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 367737003998 active site 367737003999 phosphorylation site [posttranslational modification] 367737004000 intermolecular recognition site; other site 367737004001 dimerization interface [polypeptide binding]; other site 367737004002 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737004003 DNA polymerase I; Provisional; Region: PRK05755 367737004004 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 367737004005 active site 367737004006 metal binding site 1 [ion binding]; metal-binding site 367737004007 putative 5' ssDNA interaction site; other site 367737004008 metal binding site 3; metal-binding site 367737004009 metal binding site 2 [ion binding]; metal-binding site 367737004010 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 367737004011 putative DNA binding site [nucleotide binding]; other site 367737004012 putative metal binding site [ion binding]; other site 367737004013 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 367737004014 active site 367737004015 catalytic site [active] 367737004016 substrate binding site [chemical binding]; other site 367737004017 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 367737004018 active site 367737004019 DNA binding site [nucleotide binding] 367737004020 catalytic site [active] 367737004021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 367737004022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 367737004023 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 367737004024 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 367737004025 Ligand binding site; other site 367737004026 oligomer interface; other site 367737004027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004029 metal binding site [ion binding]; metal-binding site 367737004030 active site 367737004031 I-site; other site 367737004032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737004033 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 367737004034 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 367737004035 Walker A/P-loop; other site 367737004036 ATP binding site [chemical binding]; other site 367737004037 Q-loop/lid; other site 367737004038 ABC transporter signature motif; other site 367737004039 Walker B; other site 367737004040 D-loop; other site 367737004041 H-loop/switch region; other site 367737004042 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 367737004043 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 367737004044 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 367737004045 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 367737004046 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 367737004047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737004048 RNA binding surface [nucleotide binding]; other site 367737004049 argininosuccinate synthase; Provisional; Region: PRK13820 367737004050 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 367737004051 ANP binding site [chemical binding]; other site 367737004052 Substrate Binding Site II [chemical binding]; other site 367737004053 Substrate Binding Site I [chemical binding]; other site 367737004054 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 367737004055 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 367737004056 acyl-activating enzyme (AAE) consensus motif; other site 367737004057 AMP binding site [chemical binding]; other site 367737004058 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 367737004059 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 367737004060 DltD C-terminal region; Region: DltD_C; pfam04914 367737004061 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 367737004062 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 367737004063 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 367737004064 trimer interface [polypeptide binding]; other site 367737004065 putative metal binding site [ion binding]; other site 367737004066 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 367737004067 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 367737004068 Sulfate transporter family; Region: Sulfate_transp; pfam00916 367737004069 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 367737004070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 367737004071 Ligand Binding Site [chemical binding]; other site 367737004072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 367737004073 TrkA-N domain; Region: TrkA_N; pfam02254 367737004074 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 367737004075 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 367737004076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737004077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737004078 active site 367737004079 dimerization interface [polypeptide binding]; other site 367737004080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737004081 DNA binding site [nucleotide binding] 367737004082 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 367737004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737004084 dimer interface [polypeptide binding]; other site 367737004085 phosphorylation site [posttranslational modification] 367737004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004087 ATP binding site [chemical binding]; other site 367737004088 Mg2+ binding site [ion binding]; other site 367737004089 G-X-G motif; other site 367737004090 dUTPase; Region: dUTPase_2; pfam08761 367737004091 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 367737004092 active site 367737004093 homodimer interface [polypeptide binding]; other site 367737004094 metal binding site [ion binding]; metal-binding site 367737004095 recombination protein RecR; Reviewed; Region: recR; PRK00076 367737004096 RecR protein; Region: RecR; pfam02132 367737004097 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 367737004098 putative active site [active] 367737004099 putative metal-binding site [ion binding]; other site 367737004100 tetramer interface [polypeptide binding]; other site 367737004101 chaperone protein DnaJ; Provisional; Region: PRK10767 367737004102 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367737004103 HSP70 interaction site [polypeptide binding]; other site 367737004104 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 367737004105 Zn binding sites [ion binding]; other site 367737004106 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 367737004107 dimer interface [polypeptide binding]; other site 367737004108 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 367737004109 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 367737004110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737004111 catalytic residue [active] 367737004112 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 367737004113 dinuclear metal binding motif [ion binding]; other site 367737004114 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 367737004115 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004117 metal binding site [ion binding]; metal-binding site 367737004118 active site 367737004119 I-site; other site 367737004120 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004122 metal binding site [ion binding]; metal-binding site 367737004123 active site 367737004124 I-site; other site 367737004125 Methyltransferase domain; Region: Methyltransf_31; pfam13847 367737004126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737004127 S-adenosylmethionine binding site [chemical binding]; other site 367737004128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 367737004129 ResB-like family; Region: ResB; pfam05140 367737004130 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 367737004131 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 367737004132 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 367737004133 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 367737004134 metal binding site [ion binding]; metal-binding site 367737004135 diacylglycerol kinase/D-erythro-sphingosine kinase; Region: PLN02958 367737004136 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737004137 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737004138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737004139 dimer interface [polypeptide binding]; other site 367737004140 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737004141 putative CheW interface [polypeptide binding]; other site 367737004142 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 367737004143 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 367737004144 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 367737004145 DEAD/DEAH box helicase; Region: DEAD; pfam00270 367737004146 ATP binding site [chemical binding]; other site 367737004147 putative Mg++ binding site [ion binding]; other site 367737004148 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 367737004149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737004150 nucleotide binding region [chemical binding]; other site 367737004151 ATP-binding site [chemical binding]; other site 367737004152 SEC-C motif; Region: SEC-C; pfam02810 367737004153 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 367737004154 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367737004155 FtsX-like permease family; Region: FtsX; pfam02687 367737004156 Protein of unknown function; Region: DUF3971; pfam13116 367737004157 AsmA-like C-terminal region; Region: AsmA_1; pfam13109 367737004158 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 367737004159 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 367737004160 dimerization interface [polypeptide binding]; other site 367737004161 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 367737004162 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 367737004163 malate dehydrogenase; Reviewed; Region: PRK06223 367737004164 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 367737004165 NAD(P) binding site [chemical binding]; other site 367737004166 dimer interface [polypeptide binding]; other site 367737004167 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367737004168 substrate binding site [chemical binding]; other site 367737004169 Cytochrome c; Region: Cytochrom_C; cl11414 367737004170 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 367737004171 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 367737004172 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 367737004173 NlpC/P60 family; Region: NLPC_P60; cl17555 367737004174 MraW methylase family; Region: Methyltransf_5; cl17771 367737004175 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 367737004176 hypothetical protein; Provisional; Region: PRK05834 367737004177 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 367737004178 IHF dimer interface [polypeptide binding]; other site 367737004179 IHF - DNA interface [nucleotide binding]; other site 367737004180 Arcobacter butzleri genomic island 1 (ABGI1) 367737004181 integrase; Provisional; Region: PRK09692 367737004182 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 367737004183 active site 367737004184 Int/Topo IB signature motif; other site 367737004185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737004186 ATP binding site [chemical binding]; other site 367737004187 putative Mg++ binding site [ion binding]; other site 367737004188 helicase superfamily c-terminal domain; Region: HELICc; smart00490 367737004189 nucleotide binding region [chemical binding]; other site 367737004190 ATP-binding site [chemical binding]; other site 367737004191 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 367737004192 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 367737004193 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 367737004194 Helix-turn-helix domain; Region: HTH_17; pfam12728 367737004195 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737004196 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 367737004197 Rrf2 family protein; Region: rrf2_super; TIGR00738 367737004198 Transcriptional regulator; Region: Rrf2; pfam02082 367737004199 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 367737004200 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 367737004201 Binuclear center (active site) [active] 367737004202 K-pathway; other site 367737004203 Putative proton exit pathway; other site 367737004204 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 367737004205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367737004206 Response regulator receiver domain; Region: Response_reg; pfam00072 367737004207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737004208 active site 367737004209 phosphorylation site [posttranslational modification] 367737004210 intermolecular recognition site; other site 367737004211 dimerization interface [polypeptide binding]; other site 367737004212 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 367737004213 PAS domain; Region: PAS_9; pfam13426 367737004214 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 367737004215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 367737004216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737004217 dimer interface [polypeptide binding]; other site 367737004218 phosphorylation site [posttranslational modification] 367737004219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004220 ATP binding site [chemical binding]; other site 367737004221 Mg2+ binding site [ion binding]; other site 367737004222 G-X-G motif; other site 367737004223 chaperone protein DnaJ; Provisional; Region: PRK14299 367737004224 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367737004225 HSP70 interaction site [polypeptide binding]; other site 367737004226 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 367737004227 substrate binding site [polypeptide binding]; other site 367737004228 dimer interface [polypeptide binding]; other site 367737004229 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 367737004230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 367737004231 DNA binding residues [nucleotide binding] 367737004232 putative dimer interface [polypeptide binding]; other site 367737004233 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 367737004234 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737004235 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 367737004236 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 367737004237 Walker A/P-loop; other site 367737004238 ATP binding site [chemical binding]; other site 367737004239 Q-loop/lid; other site 367737004240 ABC transporter signature motif; other site 367737004241 Walker B; other site 367737004242 D-loop; other site 367737004243 H-loop/switch region; other site 367737004244 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 367737004245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 367737004246 Walker A/P-loop; other site 367737004247 ATP binding site [chemical binding]; other site 367737004248 Q-loop/lid; other site 367737004249 ABC transporter signature motif; other site 367737004250 Walker B; other site 367737004251 D-loop; other site 367737004252 H-loop/switch region; other site 367737004253 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 367737004254 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 367737004255 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 367737004256 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 367737004257 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 367737004258 hypothetical protein; Provisional; Region: PRK14013 367737004259 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 367737004260 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 367737004261 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 367737004262 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367737004263 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367737004264 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 367737004265 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367737004266 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367737004267 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 367737004268 IMP binding site; other site 367737004269 dimer interface [polypeptide binding]; other site 367737004270 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 367737004271 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 367737004272 NodB motif; other site 367737004273 putative active site [active] 367737004274 putative catalytic site [active] 367737004275 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 367737004276 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 367737004277 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 367737004278 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 367737004279 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 367737004280 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737004281 N-terminal plug; other site 367737004282 ligand-binding site [chemical binding]; other site 367737004283 cell division protein FtsZ; Region: ftsZ; TIGR00065 367737004284 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 367737004285 nucleotide binding site [chemical binding]; other site 367737004286 SulA interaction site; other site 367737004287 cell division protein FtsA; Region: ftsA; TIGR01174 367737004288 Cell division protein FtsA; Region: FtsA; smart00842 367737004289 Cell division protein FtsA; Region: FtsA; pfam14450 367737004290 SurA N-terminal domain; Region: SurA_N_3; cl07813 367737004291 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 367737004292 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 367737004293 AAA domain; Region: AAA_30; pfam13604 367737004294 Family description; Region: UvrD_C_2; pfam13538 367737004295 adenylosuccinate synthetase; Provisional; Region: PTZ00350 367737004296 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 367737004297 ArsC family; Region: ArsC; pfam03960 367737004298 catalytic residues [active] 367737004299 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 367737004300 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 367737004301 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 367737004302 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 367737004303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737004304 ABC transporter; Region: ABC_tran_2; pfam12848 367737004305 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367737004306 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 367737004307 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 367737004308 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 367737004309 putative trimer interface [polypeptide binding]; other site 367737004310 putative CoA binding site [chemical binding]; other site 367737004311 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 367737004312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737004313 motif II; other site 367737004314 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 367737004315 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 367737004316 primosome assembly protein PriA; Validated; Region: PRK05580 367737004317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367737004318 ATP binding site [chemical binding]; other site 367737004319 putative Mg++ binding site [ion binding]; other site 367737004320 helicase superfamily c-terminal domain; Region: HELICc; smart00490 367737004321 ATP-binding site [chemical binding]; other site 367737004322 proteasome-activating nucleotidase; Provisional; Region: PRK03992 367737004323 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 367737004324 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 367737004325 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 367737004326 dimerization interface [polypeptide binding]; other site 367737004327 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 367737004328 ATP binding site [chemical binding]; other site 367737004329 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 367737004330 homodimer interface [polypeptide binding]; other site 367737004331 chemical substrate binding site [chemical binding]; other site 367737004332 oligomer interface [polypeptide binding]; other site 367737004333 metal binding site [ion binding]; metal-binding site 367737004334 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 367737004335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 367737004336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 367737004337 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 367737004338 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 367737004339 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 367737004340 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 367737004341 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 367737004342 G1 box; other site 367737004343 GTP/Mg2+ binding site [chemical binding]; other site 367737004344 G2 box; other site 367737004345 Switch I region; other site 367737004346 G3 box; other site 367737004347 Switch II region; other site 367737004348 G4 box; other site 367737004349 G5 box; other site 367737004350 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737004351 dimer interface [polypeptide binding]; other site 367737004352 putative CheW interface [polypeptide binding]; other site 367737004353 Uncharacterized conserved protein [Function unknown]; Region: COG1284 367737004354 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 367737004355 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 367737004356 flavoprotein, HI0933 family; Region: TIGR00275 367737004357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367737004358 Protein of unknown function (DUF808); Region: DUF808; cl01002 367737004359 Protein of unknown function, DUF481; Region: DUF481; pfam04338 367737004360 integral membrane protein; Region: integ_memb_HG; TIGR03954 367737004361 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 367737004362 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 367737004363 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 367737004364 Ligand Binding Site [chemical binding]; other site 367737004365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737004366 active site residue [active] 367737004367 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 367737004368 Acylphosphatase; Region: Acylphosphatase; pfam00708 367737004369 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 367737004370 HypF finger; Region: zf-HYPF; pfam07503 367737004371 HypF finger; Region: zf-HYPF; pfam07503 367737004372 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 367737004373 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 367737004374 nickel binding site [ion binding]; other site 367737004375 putative substrate-binding site; other site 367737004376 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 367737004377 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 367737004378 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 367737004379 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 367737004380 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 367737004381 fec operon regulator FecR; Reviewed; Region: PRK09774 367737004382 FecR protein; Region: FecR; pfam04773 367737004383 RNA polymerase sigma factor; Reviewed; Region: PRK12527 367737004384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737004385 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 367737004386 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 367737004387 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 367737004388 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 367737004389 putative substrate-binding site; other site 367737004390 nickel binding site [ion binding]; other site 367737004391 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 367737004392 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 367737004393 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 367737004394 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 367737004395 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 367737004396 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 367737004397 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 367737004398 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 367737004399 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 367737004400 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 367737004401 substrate binding site [chemical binding]; other site 367737004402 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 367737004403 substrate binding site [chemical binding]; other site 367737004404 ligand binding site [chemical binding]; other site 367737004405 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 367737004406 PAS fold; Region: PAS; pfam00989 367737004407 PAS domain; Region: PAS; smart00091 367737004408 putative active site [active] 367737004409 heme pocket [chemical binding]; other site 367737004410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004412 metal binding site [ion binding]; metal-binding site 367737004413 active site 367737004414 I-site; other site 367737004415 hypothetical protein; Provisional; Region: PRK12378 367737004416 VacJ like lipoprotein; Region: VacJ; cl01073 367737004417 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 367737004418 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 367737004419 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 367737004420 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 367737004421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737004422 motif II; other site 367737004423 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 367737004424 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 367737004425 catalytic residues [active] 367737004426 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 367737004427 Thioredoxin; Region: Thioredoxin_4; cl17273 367737004428 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 367737004429 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 367737004430 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 367737004431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 367737004432 active site 367737004433 RNA polymerase sigma factor; Reviewed; Region: PRK12527 367737004434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737004435 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 367737004436 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737004437 FecR protein; Region: FecR; pfam04773 367737004438 Secretin and TonB N terminus short domain; Region: STN; smart00965 367737004439 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737004440 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737004441 N-terminal plug; other site 367737004442 ligand-binding site [chemical binding]; other site 367737004443 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004445 metal binding site [ion binding]; metal-binding site 367737004446 active site 367737004447 I-site; other site 367737004448 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 367737004449 diiron binding motif [ion binding]; other site 367737004450 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 367737004451 BCCT family transporter; Region: BCCT; pfam02028 367737004452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 367737004453 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 367737004454 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 367737004455 TrkA-N domain; Region: TrkA_N; pfam02254 367737004456 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 367737004457 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 367737004458 dimer interface [polypeptide binding]; other site 367737004459 active site 367737004460 glycine-pyridoxal phosphate binding site [chemical binding]; other site 367737004461 folate binding site [chemical binding]; other site 367737004462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737004463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737004464 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 367737004465 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 367737004466 DNA binding site [nucleotide binding] 367737004467 active site 367737004468 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 367737004469 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 367737004470 minor groove reading motif; other site 367737004471 helix-hairpin-helix signature motif; other site 367737004472 substrate binding pocket [chemical binding]; other site 367737004473 active site 367737004474 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 367737004475 RNA/DNA hybrid binding site [nucleotide binding]; other site 367737004476 active site 367737004477 Putative addiction module component; Region: Unstab_antitox; pfam09720 367737004478 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 367737004479 benzoate transporter; Region: benE; TIGR00843 367737004480 Benzoate membrane transport protein; Region: BenE; pfam03594 367737004481 acetylornithine aminotransferase; Provisional; Region: PRK02627 367737004482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 367737004483 inhibitor-cofactor binding pocket; inhibition site 367737004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737004485 catalytic residue [active] 367737004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 367737004487 MOSC domain; Region: MOSC; pfam03473 367737004488 lipoyl synthase; Provisional; Region: PRK05481 367737004489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737004490 FeS/SAM binding site; other site 367737004491 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 367737004492 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 367737004493 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 367737004494 dimer interface [polypeptide binding]; other site 367737004495 TPP-binding site [chemical binding]; other site 367737004496 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 367737004497 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 367737004498 E3 interaction surface; other site 367737004499 lipoyl attachment site [posttranslational modification]; other site 367737004500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 367737004501 E3 interaction surface; other site 367737004502 lipoyl attachment site [posttranslational modification]; other site 367737004503 e3 binding domain; Region: E3_binding; pfam02817 367737004504 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 367737004505 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 367737004506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367737004507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367737004508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 367737004509 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 367737004510 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 367737004511 catalytic triad [active] 367737004512 Secretin and TonB N terminus short domain; Region: STN; pfam07660 367737004513 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 367737004514 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737004515 N-terminal plug; other site 367737004516 ligand-binding site [chemical binding]; other site 367737004517 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 367737004518 active site 367737004519 catalytic residues [active] 367737004520 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 367737004521 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 367737004522 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 367737004523 ATP binding site [chemical binding]; other site 367737004524 Mg++ binding site [ion binding]; other site 367737004525 motif III; other site 367737004526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737004527 nucleotide binding region [chemical binding]; other site 367737004528 ATP-binding site [chemical binding]; other site 367737004529 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 367737004530 AAA domain; Region: AAA_14; pfam13173 367737004531 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 367737004532 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 367737004533 cofactor binding site; other site 367737004534 DNA binding site [nucleotide binding] 367737004535 substrate interaction site [chemical binding]; other site 367737004536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367737004537 non-specific DNA binding site [nucleotide binding]; other site 367737004538 salt bridge; other site 367737004539 sequence-specific DNA binding site [nucleotide binding]; other site 367737004540 uncharacterized domain; Region: TIGR00702 367737004541 YcaO-like family; Region: YcaO; pfam02624 367737004542 Domain of unknown function DUF302; Region: DUF302; cl01364 367737004543 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 367737004544 Nitrate and nitrite sensing; Region: NIT; pfam08376 367737004545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737004546 dimer interface [polypeptide binding]; other site 367737004547 putative CheW interface [polypeptide binding]; other site 367737004548 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 367737004549 RNA/DNA hybrid binding site [nucleotide binding]; other site 367737004550 active site 367737004551 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 367737004552 active site 367737004553 catalytic residues [active] 367737004554 metal binding site [ion binding]; metal-binding site 367737004555 putative monooxygenase; Provisional; Region: PRK11118 367737004556 Protein of unknown function, DUF417; Region: DUF417; cl01162 367737004557 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 367737004558 DNA polymerase IV; Validated; Region: PRK01810 367737004559 active site 367737004560 DNA binding site [nucleotide binding] 367737004561 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 367737004562 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 367737004563 dimer interface [polypeptide binding]; other site 367737004564 putative functional site; other site 367737004565 putative MPT binding site; other site 367737004566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367737004567 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 367737004568 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 367737004569 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 367737004570 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 367737004571 4Fe-4S binding domain; Region: Fer4; cl02805 367737004572 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 367737004573 Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029 367737004574 [4Fe-4S] binding site [ion binding]; other site 367737004575 molybdopterin cofactor binding site; other site 367737004576 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737004577 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 367737004578 molybdopterin cofactor binding site; other site 367737004579 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 367737004580 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 367737004581 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 367737004582 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 367737004583 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 367737004584 putative ligand binding site [chemical binding]; other site 367737004585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004587 ATP binding site [chemical binding]; other site 367737004588 Mg2+ binding site [ion binding]; other site 367737004589 G-X-G motif; other site 367737004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737004591 Response regulator receiver domain; Region: Response_reg; pfam00072 367737004592 active site 367737004593 phosphorylation site [posttranslational modification] 367737004594 intermolecular recognition site; other site 367737004595 dimerization interface [polypeptide binding]; other site 367737004596 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 367737004597 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 367737004598 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 367737004599 metal-binding site [ion binding] 367737004600 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367737004601 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367737004602 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 367737004603 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 367737004604 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 367737004605 4Fe-4S binding domain; Region: Fer4; cl02805 367737004606 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 367737004607 [4Fe-4S] binding site [ion binding]; other site 367737004608 molybdopterin cofactor binding site; other site 367737004609 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 367737004610 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 367737004611 molybdopterin cofactor binding site; other site 367737004612 selenophosphate synthetase; Provisional; Region: PRK00943 367737004613 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 367737004614 dimerization interface [polypeptide binding]; other site 367737004615 putative ATP binding site [chemical binding]; other site 367737004616 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 367737004617 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 367737004618 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 367737004619 catalytic residue [active] 367737004620 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 367737004621 Sel1-like repeats; Region: SEL1; smart00671 367737004622 Sel1-like repeats; Region: SEL1; smart00671 367737004623 selenocysteine synthase; Provisional; Region: PRK04311 367737004624 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 367737004625 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 367737004626 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 367737004627 G1 box; other site 367737004628 putative GEF interaction site [polypeptide binding]; other site 367737004629 GTP/Mg2+ binding site [chemical binding]; other site 367737004630 Switch I region; other site 367737004631 G2 box; other site 367737004632 G3 box; other site 367737004633 Switch II region; other site 367737004634 G4 box; other site 367737004635 G5 box; other site 367737004636 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 367737004637 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 367737004638 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 367737004639 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 367737004640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 367737004641 ATP binding site [chemical binding]; other site 367737004642 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737004643 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737004644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737004645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737004646 dimer interface [polypeptide binding]; other site 367737004647 phosphorylation site [posttranslational modification] 367737004648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004649 ATP binding site [chemical binding]; other site 367737004650 Mg2+ binding site [ion binding]; other site 367737004651 G-X-G motif; other site 367737004652 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 367737004653 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 367737004654 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 367737004655 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 367737004656 putative active site [active] 367737004657 PhoH-like protein; Region: PhoH; cl17668 367737004658 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 367737004659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737004660 PAS domain; Region: PAS_9; pfam13426 367737004661 putative active site [active] 367737004662 heme pocket [chemical binding]; other site 367737004663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004664 metal binding site [ion binding]; metal-binding site 367737004665 active site 367737004666 I-site; other site 367737004667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737004668 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 367737004669 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 367737004670 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 367737004671 GAF domain; Region: GAF_2; pfam13185 367737004672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737004673 PAS domain; Region: PAS_9; pfam13426 367737004674 putative active site [active] 367737004675 heme pocket [chemical binding]; other site 367737004676 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004678 metal binding site [ion binding]; metal-binding site 367737004679 active site 367737004680 I-site; other site 367737004681 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 367737004682 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 367737004683 ATP binding site [chemical binding]; other site 367737004684 Mg++ binding site [ion binding]; other site 367737004685 motif III; other site 367737004686 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737004687 nucleotide binding region [chemical binding]; other site 367737004688 ATP-binding site [chemical binding]; other site 367737004689 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 367737004690 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 367737004691 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 367737004692 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 367737004693 heat shock protein 90; Provisional; Region: PRK05218 367737004694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004695 ATP binding site [chemical binding]; other site 367737004696 Mg2+ binding site [ion binding]; other site 367737004697 G-X-G motif; other site 367737004698 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 367737004699 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 367737004700 dimer interface [polypeptide binding]; other site 367737004701 active site 367737004702 heme binding site [chemical binding]; other site 367737004703 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 367737004704 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737004705 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737004706 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737004707 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 367737004708 mce related protein; Region: MCE; pfam02470 367737004709 mce related protein; Region: MCE; pfam02470 367737004710 mce related protein; Region: MCE; pfam02470 367737004711 mce related protein; Region: MCE; pfam02470 367737004712 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 367737004713 heme-binding site [chemical binding]; other site 367737004714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737004715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737004716 metal binding site [ion binding]; metal-binding site 367737004717 active site 367737004718 I-site; other site 367737004719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737004720 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 367737004721 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 367737004722 EamA-like transporter family; Region: EamA; pfam00892 367737004723 EamA-like transporter family; Region: EamA; pfam00892 367737004724 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 367737004725 putative deacylase active site [active] 367737004726 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 367737004727 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 367737004728 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 367737004729 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 367737004730 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 367737004731 conserved cys residue [active] 367737004732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737004733 S-adenosylmethionine binding site [chemical binding]; other site 367737004734 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 367737004735 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737004736 N-terminal plug; other site 367737004737 ligand-binding site [chemical binding]; other site 367737004738 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 367737004739 HicB family; Region: HicB; pfam05534 367737004740 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737004741 FecR protein; Region: FecR; pfam04773 367737004742 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 367737004743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737004744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737004745 DNA binding residues [nucleotide binding] 367737004746 agmatinase; Region: agmatinase; TIGR01230 367737004747 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 367737004748 putative active site [active] 367737004749 Mn binding site [ion binding]; other site 367737004750 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 367737004751 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 367737004752 active site 367737004753 catalytic residues [active] 367737004754 metal binding site [ion binding]; metal-binding site 367737004755 Helix-turn-helix domain; Region: HTH_18; pfam12833 367737004756 PemK-like protein; Region: PemK; pfam02452 367737004757 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 367737004758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737004759 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737004760 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737004761 N-terminal plug; other site 367737004762 ligand-binding site [chemical binding]; other site 367737004763 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 367737004764 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 367737004765 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 367737004766 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 367737004767 Mechanosensitive ion channel; Region: MS_channel; pfam00924 367737004768 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 367737004769 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 367737004770 DHHA2 domain; Region: DHHA2; pfam02833 367737004771 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 367737004772 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 367737004773 active site 367737004774 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 367737004775 Aspartase; Region: Aspartase; cd01357 367737004776 active sites [active] 367737004777 tetramer interface [polypeptide binding]; other site 367737004778 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737004779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737004780 active site 367737004781 phosphorylation site [posttranslational modification] 367737004782 intermolecular recognition site; other site 367737004783 dimerization interface [polypeptide binding]; other site 367737004784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 367737004785 DNA binding site [nucleotide binding] 367737004786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737004787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004788 ATP binding site [chemical binding]; other site 367737004789 Mg2+ binding site [ion binding]; other site 367737004790 G-X-G motif; other site 367737004791 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 367737004792 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 367737004793 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 367737004794 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 367737004795 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 367737004796 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 367737004797 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 367737004798 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 367737004799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737004800 binding surface 367737004801 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 367737004802 TPR motif; other site 367737004803 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 367737004804 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 367737004805 ligand binding site [chemical binding]; other site 367737004806 translocation protein TolB; Provisional; Region: tolB; PRK04043 367737004807 TonB C terminal; Region: TonB_2; pfam13103 367737004808 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 367737004809 TolR protein; Region: tolR; TIGR02801 367737004810 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 367737004811 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 367737004812 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 367737004813 gamma subunit interface [polypeptide binding]; other site 367737004814 epsilon subunit interface [polypeptide binding]; other site 367737004815 LBP interface [polypeptide binding]; other site 367737004816 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 367737004817 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 367737004818 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 367737004819 alpha subunit interaction interface [polypeptide binding]; other site 367737004820 Walker A motif; other site 367737004821 ATP binding site [chemical binding]; other site 367737004822 Walker B motif; other site 367737004823 inhibitor binding site; inhibition site 367737004824 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 367737004825 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 367737004826 core domain interface [polypeptide binding]; other site 367737004827 delta subunit interface [polypeptide binding]; other site 367737004828 epsilon subunit interface [polypeptide binding]; other site 367737004829 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 367737004830 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 367737004831 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 367737004832 beta subunit interaction interface [polypeptide binding]; other site 367737004833 Walker A motif; other site 367737004834 ATP binding site [chemical binding]; other site 367737004835 Walker B motif; other site 367737004836 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 367737004837 F0F1 ATP synthase subunit delta; Validated; Region: PRK08474 367737004838 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 367737004839 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 367737004840 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 367737004841 F0F1 ATP synthase subunit B'; Validated; Region: PRK08476 367737004842 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 367737004843 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 367737004844 ParB-like nuclease domain; Region: ParB; smart00470 367737004845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367737004846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367737004847 P-loop; other site 367737004848 Magnesium ion binding site [ion binding]; other site 367737004849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367737004850 Magnesium ion binding site [ion binding]; other site 367737004851 biotin--protein ligase; Provisional; Region: PRK08477 367737004852 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 367737004853 Predicted permeases [General function prediction only]; Region: COG0679 367737004854 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 367737004855 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 367737004856 putative active site [active] 367737004857 substrate binding site [chemical binding]; other site 367737004858 putative cosubstrate binding site; other site 367737004859 catalytic site [active] 367737004860 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 367737004861 substrate binding site [chemical binding]; other site 367737004862 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 367737004863 nucleotide binding site [chemical binding]; other site 367737004864 homotetrameric interface [polypeptide binding]; other site 367737004865 putative phosphate binding site [ion binding]; other site 367737004866 putative allosteric binding site; other site 367737004867 GTPase CgtA; Reviewed; Region: obgE; PRK12299 367737004868 GTP1/OBG; Region: GTP1_OBG; pfam01018 367737004869 Obg GTPase; Region: Obg; cd01898 367737004870 G1 box; other site 367737004871 GTP/Mg2+ binding site [chemical binding]; other site 367737004872 Switch I region; other site 367737004873 G2 box; other site 367737004874 G3 box; other site 367737004875 Switch II region; other site 367737004876 G4 box; other site 367737004877 G5 box; other site 367737004878 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 367737004879 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 367737004880 DNA primase; Validated; Region: dnaG; PRK05667 367737004881 CHC2 zinc finger; Region: zf-CHC2; pfam01807 367737004882 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 367737004883 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 367737004884 active site 367737004885 metal binding site [ion binding]; metal-binding site 367737004886 interdomain interaction site; other site 367737004887 ribonuclease III; Reviewed; Region: rnc; PRK00102 367737004888 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 367737004889 dimerization interface [polypeptide binding]; other site 367737004890 active site 367737004891 metal binding site [ion binding]; metal-binding site 367737004892 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 367737004893 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 367737004894 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 367737004895 Tetramer interface [polypeptide binding]; other site 367737004896 active site 367737004897 FMN-binding site [chemical binding]; other site 367737004898 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 367737004899 M48 family peptidase; Provisional; Region: PRK03001 367737004900 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 367737004901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367737004902 catalytic core [active] 367737004903 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 367737004904 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 367737004905 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 367737004906 trmE is a tRNA modification GTPase; Region: trmE; cd04164 367737004907 G1 box; other site 367737004908 G1 box; other site 367737004909 GTP/Mg2+ binding site [chemical binding]; other site 367737004910 GTP/Mg2+ binding site [chemical binding]; other site 367737004911 Switch I region; other site 367737004912 G2 box; other site 367737004913 Switch II region; other site 367737004914 G3 box; other site 367737004915 G4 box; other site 367737004916 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 367737004917 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 367737004918 membrane protein insertase; Provisional; Region: PRK01318 367737004919 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 367737004920 Haemolytic domain; Region: Haemolytic; pfam01809 367737004921 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 367737004922 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 367737004923 Clp amino terminal domain; Region: Clp_N; pfam02861 367737004924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737004925 Walker A motif; other site 367737004926 ATP binding site [chemical binding]; other site 367737004927 Walker B motif; other site 367737004928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737004929 Walker A motif; other site 367737004930 ATP binding site [chemical binding]; other site 367737004931 Walker B motif; other site 367737004932 arginine finger; other site 367737004933 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 367737004934 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 367737004935 RNA/DNA hybrid binding site [nucleotide binding]; other site 367737004936 active site 367737004937 Domain of unknown function DUF77; Region: DUF77; cl00307 367737004938 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 367737004939 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 367737004940 methionine sulfoxide reductase B; Provisional; Region: PRK05508 367737004941 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 367737004942 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 367737004943 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 367737004944 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 367737004945 putative active site [active] 367737004946 putative CoA binding site [chemical binding]; other site 367737004947 nudix motif; other site 367737004948 metal binding site [ion binding]; metal-binding site 367737004949 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 367737004950 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 367737004951 inhibitor-cofactor binding pocket; inhibition site 367737004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737004953 catalytic residue [active] 367737004954 NMT1/THI5 like; Region: NMT1; pfam09084 367737004955 ATP phosphoribosyltransferase; Region: HisG; cl15266 367737004956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367737004957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367737004958 substrate binding pocket [chemical binding]; other site 367737004959 membrane-bound complex binding site; other site 367737004960 hinge residues; other site 367737004961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737004962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737004963 ATP binding site [chemical binding]; other site 367737004964 Mg2+ binding site [ion binding]; other site 367737004965 G-X-G motif; other site 367737004966 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 367737004967 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 367737004968 purine monophosphate binding site [chemical binding]; other site 367737004969 dimer interface [polypeptide binding]; other site 367737004970 putative catalytic residues [active] 367737004971 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 367737004972 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 367737004973 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 367737004974 dimerization interface [polypeptide binding]; other site 367737004975 ATP binding site [chemical binding]; other site 367737004976 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 367737004977 dimerization interface [polypeptide binding]; other site 367737004978 ATP binding site [chemical binding]; other site 367737004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 367737004980 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 367737004981 Peptidase family M23; Region: Peptidase_M23; pfam01551 367737004982 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 367737004983 homodecamer interface [polypeptide binding]; other site 367737004984 GTP cyclohydrolase I; Provisional; Region: PLN03044 367737004985 active site 367737004986 putative catalytic site residues [active] 367737004987 zinc binding site [ion binding]; other site 367737004988 GTP-CH-I/GFRP interaction surface; other site 367737004989 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 367737004990 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 367737004991 Cl binding site [ion binding]; other site 367737004992 oligomer interface [polypeptide binding]; other site 367737004993 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 367737004994 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 367737004995 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 367737004996 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 367737004997 Walker A motif; other site 367737004998 ATP binding site [chemical binding]; other site 367737004999 Walker B motif; other site 367737005000 Flagellin N-methylase; Region: FliB; pfam03692 367737005001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 367737005002 Catalytic site [active] 367737005003 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 367737005004 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 367737005005 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 367737005006 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 367737005007 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 367737005008 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 367737005009 Phage tail tube protein FII; Region: Phage_tube; cl01390 367737005010 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 367737005011 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 367737005012 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 367737005013 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 367737005014 Baseplate J-like protein; Region: Baseplate_J; cl01294 367737005015 Baseplate J-like protein; Region: Baseplate_J; cl01294 367737005016 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 367737005017 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 367737005018 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 367737005019 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 367737005020 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 367737005021 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 367737005022 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 367737005023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 367737005024 Protein of unknown function (DUF935); Region: DUF935; pfam06074 367737005025 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 367737005026 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 367737005027 Mor transcription activator family; Region: Mor; cl02360 367737005028 AAA domain; Region: AAA_25; pfam13481 367737005029 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 367737005030 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 367737005031 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 367737005032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 367737005033 DNA binding site [nucleotide binding] 367737005034 AAA domain; Region: AAA_22; pfam13401 367737005035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737005036 Walker B; other site 367737005037 D-loop; other site 367737005038 Integrase core domain; Region: rve; pfam00665 367737005039 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 367737005040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367737005041 non-specific DNA binding site [nucleotide binding]; other site 367737005042 salt bridge; other site 367737005043 sequence-specific DNA binding site [nucleotide binding]; other site 367737005044 Predicted transcriptional regulator [Transcription]; Region: COG2932 367737005045 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 367737005046 Catalytic site [active] 367737005047 GTPase Era; Reviewed; Region: era; PRK00089 367737005048 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 367737005049 G1 box; other site 367737005050 GTP/Mg2+ binding site [chemical binding]; other site 367737005051 Switch I region; other site 367737005052 G2 box; other site 367737005053 Switch II region; other site 367737005054 G3 box; other site 367737005055 G4 box; other site 367737005056 G5 box; other site 367737005057 KH domain; Region: KH_2; pfam07650 367737005058 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 367737005059 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 367737005060 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 367737005061 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 367737005062 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 367737005063 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 367737005064 active site 367737005065 catalytic residues [active] 367737005066 metal binding site [ion binding]; metal-binding site 367737005067 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 367737005068 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 367737005069 oligomer interface [polypeptide binding]; other site 367737005070 active site residues [active] 367737005071 trigger factor; Provisional; Region: tig; PRK01490 367737005072 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 367737005073 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 367737005074 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 367737005075 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 367737005076 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 367737005077 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 367737005078 dimer interface [polypeptide binding]; other site 367737005079 active site 367737005080 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367737005081 catalytic residues [active] 367737005082 substrate binding site [chemical binding]; other site 367737005083 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 367737005084 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 367737005085 NAD(P) binding pocket [chemical binding]; other site 367737005086 Arcobacter butzleri genomic island 2 (ABGI2) 367737005087 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 367737005088 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 367737005089 active site 367737005090 catalytic residues [active] 367737005091 DNA binding site [nucleotide binding] 367737005092 Int/Topo IB signature motif; other site 367737005093 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 367737005094 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 367737005095 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 367737005096 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 367737005097 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 367737005098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 367737005099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737005100 AAA domain; Region: AAA_21; pfam13304 367737005101 Walker A/P-loop; other site 367737005102 ATP binding site [chemical binding]; other site 367737005103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 367737005104 ABC transporter signature motif; other site 367737005105 Walker B; other site 367737005106 D-loop; other site 367737005107 H-loop/switch region; other site 367737005108 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 367737005109 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 367737005110 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 367737005111 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 367737005112 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 367737005113 HSP70 interaction site [polypeptide binding]; other site 367737005114 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 367737005115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 367737005116 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 367737005117 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367737005118 homodimer interface [polypeptide binding]; other site 367737005119 substrate-cofactor binding pocket; other site 367737005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737005121 catalytic residue [active] 367737005122 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367737005123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737005124 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 367737005125 catalytic residue [active] 367737005126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005128 active site 367737005129 phosphorylation site [posttranslational modification] 367737005130 intermolecular recognition site; other site 367737005131 dimerization interface [polypeptide binding]; other site 367737005132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737005133 DNA binding site [nucleotide binding] 367737005134 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 367737005135 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005136 dimer interface [polypeptide binding]; other site 367737005137 putative CheW interface [polypeptide binding]; other site 367737005138 Response regulator receiver domain; Region: Response_reg; pfam00072 367737005139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005140 active site 367737005141 phosphorylation site [posttranslational modification] 367737005142 intermolecular recognition site; other site 367737005143 dimerization interface [polypeptide binding]; other site 367737005144 Response regulator receiver domain; Region: Response_reg; pfam00072 367737005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005146 active site 367737005147 phosphorylation site [posttranslational modification] 367737005148 intermolecular recognition site; other site 367737005149 dimerization interface [polypeptide binding]; other site 367737005150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737005151 PAS domain; Region: PAS_9; pfam13426 367737005152 putative active site [active] 367737005153 heme pocket [chemical binding]; other site 367737005154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737005155 PAS domain; Region: PAS_9; pfam13426 367737005156 putative active site [active] 367737005157 heme pocket [chemical binding]; other site 367737005158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737005159 Zn2+ binding site [ion binding]; other site 367737005160 Mg2+ binding site [ion binding]; other site 367737005161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005162 dimer interface [polypeptide binding]; other site 367737005163 putative CheW interface [polypeptide binding]; other site 367737005164 NMT1/THI5 like; Region: NMT1; pfam09084 367737005165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367737005166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367737005167 substrate binding pocket [chemical binding]; other site 367737005168 membrane-bound complex binding site; other site 367737005169 hinge residues; other site 367737005170 PAS domain S-box; Region: sensory_box; TIGR00229 367737005171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737005172 putative active site [active] 367737005173 heme pocket [chemical binding]; other site 367737005174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737005175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737005176 ATP binding site [chemical binding]; other site 367737005177 Mg2+ binding site [ion binding]; other site 367737005178 G-X-G motif; other site 367737005179 Predicted permeases [General function prediction only]; Region: COG0679 367737005180 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 367737005181 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 367737005182 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 367737005183 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 367737005184 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 367737005185 catalytic residues [active] 367737005186 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 367737005187 Cytochrome c; Region: Cytochrom_C; cl11414 367737005188 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 367737005189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737005190 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737005191 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 367737005192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367737005193 Coenzyme A binding pocket [chemical binding]; other site 367737005194 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 367737005195 High-affinity nickel-transport protein; Region: NicO; cl00964 367737005196 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 367737005197 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 367737005198 putative metal binding residues [ion binding]; other site 367737005199 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 367737005200 metal binding site 2 [ion binding]; metal-binding site 367737005201 putative DNA binding helix; other site 367737005202 metal binding site 1 [ion binding]; metal-binding site 367737005203 dimer interface [polypeptide binding]; other site 367737005204 structural Zn2+ binding site [ion binding]; other site 367737005205 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 367737005206 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 367737005207 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 367737005208 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 367737005209 Imelysin; Region: Peptidase_M75; pfam09375 367737005210 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 367737005211 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 367737005212 Imelysin; Region: Peptidase_M75; cl09159 367737005213 F0F1 ATP synthase subunit C; Validated; Region: PRK08482 367737005214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005215 dimer interface [polypeptide binding]; other site 367737005216 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737005217 putative CheW interface [polypeptide binding]; other site 367737005218 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 367737005219 Domain of unknown function DUF20; Region: UPF0118; pfam01594 367737005220 Ion transport protein; Region: Ion_trans; pfam00520 367737005221 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 367737005222 dimer interface [polypeptide binding]; other site 367737005223 substrate binding site [chemical binding]; other site 367737005224 ATP binding site [chemical binding]; other site 367737005225 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 367737005226 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 367737005227 putative catalytic cysteine [active] 367737005228 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 367737005229 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 367737005230 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 367737005231 4Fe-4S binding domain; Region: Fer4_5; pfam12801 367737005232 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 367737005233 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 367737005234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 367737005235 dimer interface [polypeptide binding]; other site 367737005236 phosphorylation site [posttranslational modification] 367737005237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737005238 ATP binding site [chemical binding]; other site 367737005239 Mg2+ binding site [ion binding]; other site 367737005240 G-X-G motif; other site 367737005241 Response regulator receiver domain; Region: Response_reg; pfam00072 367737005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005243 active site 367737005244 phosphorylation site [posttranslational modification] 367737005245 intermolecular recognition site; other site 367737005246 dimerization interface [polypeptide binding]; other site 367737005247 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737005248 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 367737005249 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 367737005250 DNA binding site [nucleotide binding] 367737005251 active site 367737005252 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 367737005253 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 367737005254 active site 367737005255 substrate binding site [chemical binding]; other site 367737005256 metal binding site [ion binding]; metal-binding site 367737005257 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 367737005258 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 367737005259 active site 367737005260 catalytic triad [active] 367737005261 dimer interface [polypeptide binding]; other site 367737005262 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 367737005263 catalytic residue [active] 367737005264 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 367737005265 flavodoxin FldA; Validated; Region: PRK09267 367737005266 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 367737005267 metal binding site 2 [ion binding]; metal-binding site 367737005268 putative DNA binding helix; other site 367737005269 metal binding site 1 [ion binding]; metal-binding site 367737005270 dimer interface [polypeptide binding]; other site 367737005271 structural Zn2+ binding site [ion binding]; other site 367737005272 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 367737005273 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 367737005274 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 367737005275 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 367737005276 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 367737005277 substrate binding site [chemical binding]; other site 367737005278 active site 367737005279 catalytic residues [active] 367737005280 heterodimer interface [polypeptide binding]; other site 367737005281 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 367737005282 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 367737005283 Cl- selectivity filter; other site 367737005284 Cl- binding residues [ion binding]; other site 367737005285 pore gating glutamate residue; other site 367737005286 dimer interface [polypeptide binding]; other site 367737005287 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 367737005288 active site 367737005289 oligomerization interface [polypeptide binding]; other site 367737005290 metal binding site [ion binding]; metal-binding site 367737005291 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 367737005292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737005293 Walker A motif; other site 367737005294 ATP binding site [chemical binding]; other site 367737005295 Walker B motif; other site 367737005296 arginine finger; other site 367737005297 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 367737005298 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 367737005299 Domain of unknown function DUF20; Region: UPF0118; pfam01594 367737005300 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 367737005301 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737005302 active site residue [active] 367737005303 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 367737005304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737005305 FeS/SAM binding site; other site 367737005306 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 367737005307 substrate binding site [chemical binding]; other site 367737005308 active site 367737005309 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 367737005310 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 367737005311 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 367737005312 DNA gyrase subunit A; Validated; Region: PRK05560 367737005313 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 367737005314 CAP-like domain; other site 367737005315 active site 367737005316 primary dimer interface [polypeptide binding]; other site 367737005317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367737005323 Protein of unknown function (DUF465); Region: DUF465; cl01070 367737005324 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 367737005325 heterotetramer interface [polypeptide binding]; other site 367737005326 active site pocket [active] 367737005327 cleavage site 367737005328 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 367737005329 TrkA-N domain; Region: TrkA_N; pfam02254 367737005330 TrkA-C domain; Region: TrkA_C; pfam02080 367737005331 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 367737005332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367737005333 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 367737005334 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 367737005335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737005336 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 367737005337 NAD(P) binding site [chemical binding]; other site 367737005338 active site 367737005339 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 367737005340 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 367737005341 putative ribose interaction site [chemical binding]; other site 367737005342 putative ADP binding site [chemical binding]; other site 367737005343 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 367737005344 active site 367737005345 nucleotide binding site [chemical binding]; other site 367737005346 HIGH motif; other site 367737005347 KMSKS motif; other site 367737005348 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 367737005349 dimer interface [polypeptide binding]; other site 367737005350 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 367737005351 active site 367737005352 Sulfatase; Region: Sulfatase; pfam00884 367737005353 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 367737005354 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 367737005355 putative active site [active] 367737005356 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 367737005357 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 367737005358 putative active site [active] 367737005359 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 367737005360 Sulfatase; Region: Sulfatase; cl17466 367737005361 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 367737005362 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 367737005363 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 367737005364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737005365 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 367737005366 putative metal binding site; other site 367737005367 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367737005368 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737005369 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 367737005370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367737005371 active site 367737005372 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 367737005373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367737005374 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 367737005375 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 367737005376 O-Antigen ligase; Region: Wzy_C; pfam04932 367737005377 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 367737005378 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 367737005379 inhibitor-cofactor binding pocket; inhibition site 367737005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737005381 catalytic residue [active] 367737005382 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 367737005383 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 367737005384 NAD binding site [chemical binding]; other site 367737005385 substrate binding site [chemical binding]; other site 367737005386 homodimer interface [polypeptide binding]; other site 367737005387 active site 367737005388 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 367737005389 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 367737005390 substrate binding site; other site 367737005391 tetramer interface; other site 367737005392 Sulfatase; Region: Sulfatase; cl17466 367737005393 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 367737005394 serine/threonine protein kinase; Provisional; Region: PRK14879 367737005395 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 367737005396 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 367737005397 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 367737005398 putative acyl-acceptor binding pocket; other site 367737005399 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 367737005400 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 367737005401 putative active site [active] 367737005402 exopolyphosphatase; Region: exo_poly_only; TIGR03706 367737005403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367737005404 nucleotide binding site [chemical binding]; other site 367737005405 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 367737005406 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 367737005407 active site 367737005408 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 367737005409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367737005410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367737005411 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 367737005412 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 367737005413 active site 367737005414 dimer interface [polypeptide binding]; other site 367737005415 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 367737005416 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 367737005417 active site 367737005418 FMN binding site [chemical binding]; other site 367737005419 substrate binding site [chemical binding]; other site 367737005420 3Fe-4S cluster binding site [ion binding]; other site 367737005421 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 367737005422 domain_subunit interface; other site 367737005423 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 367737005424 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 367737005425 Cache domain; Region: Cache_1; pfam02743 367737005426 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005427 dimer interface [polypeptide binding]; other site 367737005428 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737005429 putative CheW interface [polypeptide binding]; other site 367737005430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005431 dimer interface [polypeptide binding]; other site 367737005432 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 367737005433 putative CheW interface [polypeptide binding]; other site 367737005434 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 367737005435 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 367737005436 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 367737005437 Uncharacterized conserved protein [Function unknown]; Region: COG1739 367737005438 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 367737005439 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 367737005440 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 367737005441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367737005442 RNA binding surface [nucleotide binding]; other site 367737005443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737005444 S-adenosylmethionine binding site [chemical binding]; other site 367737005445 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 367737005446 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367737005447 active site 367737005448 nucleotide binding site [chemical binding]; other site 367737005449 HIGH motif; other site 367737005450 KMSKS motif; other site 367737005451 Riboflavin kinase; Region: Flavokinase; pfam01687 367737005452 Methyltransferase domain; Region: Methyltransf_23; pfam13489 367737005453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737005454 S-adenosylmethionine binding site [chemical binding]; other site 367737005455 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 367737005456 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 367737005457 catalytic triad [active] 367737005458 FAD binding domain; Region: FAD_binding_4; pfam01565 367737005459 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 367737005460 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 367737005461 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 367737005462 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 367737005463 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 367737005464 hinge; other site 367737005465 active site 367737005466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367737005467 EamA-like transporter family; Region: EamA; pfam00892 367737005468 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 367737005469 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 367737005470 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 367737005471 homopentamer interface [polypeptide binding]; other site 367737005472 active site 367737005473 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 367737005474 putative RNA binding site [nucleotide binding]; other site 367737005475 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 367737005476 active site 367737005477 dimer interface [polypeptide binding]; other site 367737005478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 367737005479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 367737005480 Walker A/P-loop; other site 367737005481 ATP binding site [chemical binding]; other site 367737005482 Q-loop/lid; other site 367737005483 ABC transporter signature motif; other site 367737005484 Walker B; other site 367737005485 D-loop; other site 367737005486 H-loop/switch region; other site 367737005487 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 367737005488 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 367737005489 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 367737005490 G1 box; other site 367737005491 GTP/Mg2+ binding site [chemical binding]; other site 367737005492 Switch I region; other site 367737005493 G2 box; other site 367737005494 G3 box; other site 367737005495 Switch II region; other site 367737005496 G4 box; other site 367737005497 G5 box; other site 367737005498 Nucleoside recognition; Region: Gate; pfam07670 367737005499 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 367737005500 Nucleoside recognition; Region: Gate; pfam07670 367737005501 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 367737005502 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 367737005503 Heavy-metal-associated domain; Region: HMA; pfam00403 367737005504 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 367737005505 metal-binding site [ion binding] 367737005506 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367737005507 Soluble P-type ATPase [General function prediction only]; Region: COG4087 367737005508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367737005509 dimerization interface [polypeptide binding]; other site 367737005510 putative DNA binding site [nucleotide binding]; other site 367737005511 putative Zn2+ binding site [ion binding]; other site 367737005512 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 367737005513 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737005514 N-terminal plug; other site 367737005515 ligand-binding site [chemical binding]; other site 367737005516 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 367737005517 Protein export membrane protein; Region: SecD_SecF; cl14618 367737005518 Protein export membrane protein; Region: SecD_SecF; cl14618 367737005519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 367737005520 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737005521 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 367737005522 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 367737005523 DNA-binding site [nucleotide binding]; DNA binding site 367737005524 RNA-binding motif; other site 367737005525 Response regulator receiver domain; Region: Response_reg; pfam00072 367737005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005527 active site 367737005528 phosphorylation site [posttranslational modification] 367737005529 intermolecular recognition site; other site 367737005530 dimerization interface [polypeptide binding]; other site 367737005531 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 367737005532 DNA binding site [nucleotide binding] 367737005533 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 367737005534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737005535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 367737005536 dimer interface [polypeptide binding]; other site 367737005537 phosphorylation site [posttranslational modification] 367737005538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737005539 ATP binding site [chemical binding]; other site 367737005540 Mg2+ binding site [ion binding]; other site 367737005541 G-X-G motif; other site 367737005542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 367737005543 active site 367737005544 DNA binding site [nucleotide binding] 367737005545 Int/Topo IB signature motif; other site 367737005546 Initiator Replication protein; Region: Rep_3; pfam01051 367737005547 V-type ATP synthase subunit I; Validated; Region: PRK05771 367737005548 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 367737005549 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 367737005550 dimer interface [polypeptide binding]; other site 367737005551 decamer (pentamer of dimers) interface [polypeptide binding]; other site 367737005552 catalytic triad [active] 367737005553 peroxidatic and resolving cysteines [active] 367737005554 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 367737005555 catalytic residues [active] 367737005556 YCII-related domain; Region: YCII; cl00999 367737005557 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 367737005558 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 367737005559 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 367737005560 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 367737005561 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 367737005562 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 367737005563 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 367737005564 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 367737005565 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 367737005566 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 367737005567 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 367737005568 DNA binding site [nucleotide binding] 367737005569 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 367737005570 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 367737005571 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 367737005572 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 367737005573 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 367737005574 RPB3 interaction site [polypeptide binding]; other site 367737005575 RPB1 interaction site [polypeptide binding]; other site 367737005576 RPB11 interaction site [polypeptide binding]; other site 367737005577 RPB10 interaction site [polypeptide binding]; other site 367737005578 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 367737005579 L11 interface [polypeptide binding]; other site 367737005580 putative EF-Tu interaction site [polypeptide binding]; other site 367737005581 putative EF-G interaction site [polypeptide binding]; other site 367737005582 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 367737005583 23S rRNA interface [nucleotide binding]; other site 367737005584 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 367737005585 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 367737005586 mRNA/rRNA interface [nucleotide binding]; other site 367737005587 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 367737005588 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 367737005589 23S rRNA interface [nucleotide binding]; other site 367737005590 L7/L12 interface [polypeptide binding]; other site 367737005591 putative thiostrepton binding site; other site 367737005592 L25 interface [polypeptide binding]; other site 367737005593 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 367737005594 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 367737005595 putative homodimer interface [polypeptide binding]; other site 367737005596 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 367737005597 heterodimer interface [polypeptide binding]; other site 367737005598 homodimer interface [polypeptide binding]; other site 367737005599 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 367737005600 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 367737005601 elongation factor Tu; Reviewed; Region: PRK00049 367737005602 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 367737005603 G1 box; other site 367737005604 GEF interaction site [polypeptide binding]; other site 367737005605 GTP/Mg2+ binding site [chemical binding]; other site 367737005606 Switch I region; other site 367737005607 G2 box; other site 367737005608 G3 box; other site 367737005609 Switch II region; other site 367737005610 G4 box; other site 367737005611 G5 box; other site 367737005612 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 367737005613 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 367737005614 Antibiotic Binding Site [chemical binding]; other site 367737005615 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 367737005616 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367737005617 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 367737005618 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 367737005619 Mg++ binding site [ion binding]; other site 367737005620 putative catalytic motif [active] 367737005621 putative substrate binding site [chemical binding]; other site 367737005622 phosphoglyceromutase; Provisional; Region: PRK05434 367737005623 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 367737005624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 367737005625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737005626 Walker A/P-loop; other site 367737005627 ATP binding site [chemical binding]; other site 367737005628 Q-loop/lid; other site 367737005629 ABC transporter signature motif; other site 367737005630 Walker B; other site 367737005631 D-loop; other site 367737005632 H-loop/switch region; other site 367737005633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 367737005634 Transglycosylase; Region: Transgly; pfam00912 367737005635 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 367737005636 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 367737005637 glutamine synthetase, type I; Region: GlnA; TIGR00653 367737005638 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 367737005639 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 367737005640 histidinol-phosphatase; Provisional; Region: PRK07328 367737005641 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 367737005642 active site 367737005643 dimer interface [polypeptide binding]; other site 367737005644 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 367737005645 MoaE homodimer interface [polypeptide binding]; other site 367737005646 MoaD interaction [polypeptide binding]; other site 367737005647 active site residues [active] 367737005648 charged pocket; other site 367737005649 ThiS family; Region: ThiS; pfam02597 367737005650 hydrophobic patch; other site 367737005651 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 367737005652 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 367737005653 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 367737005654 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 367737005655 active site 367737005656 homodimer interface [polypeptide binding]; other site 367737005657 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 367737005658 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 367737005659 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 367737005660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 367737005661 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 367737005662 active site 367737005663 Cytochrome c; Region: Cytochrom_C; cl11414 367737005664 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 367737005665 Clp amino terminal domain; Region: Clp_N; pfam02861 367737005666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737005667 Walker A motif; other site 367737005668 ATP binding site [chemical binding]; other site 367737005669 Walker B motif; other site 367737005670 arginine finger; other site 367737005671 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 367737005672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737005673 Walker A motif; other site 367737005674 ATP binding site [chemical binding]; other site 367737005675 Walker B motif; other site 367737005676 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 367737005677 Uncharacterized conserved protein [Function unknown]; Region: COG2127 367737005678 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 367737005679 AAA domain; Region: AAA_26; pfam13500 367737005680 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 367737005681 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 367737005682 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 367737005683 acyl-activating enzyme (AAE) consensus motif; other site 367737005684 AMP binding site [chemical binding]; other site 367737005685 active site 367737005686 CoA binding site [chemical binding]; other site 367737005687 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 367737005688 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 367737005689 putative active site [active] 367737005690 putative catalytic site [active] 367737005691 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 367737005692 putative active site [active] 367737005693 putative catalytic site [active] 367737005694 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 367737005695 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 367737005696 Fumarase C-terminus; Region: Fumerase_C; pfam05683 367737005697 Nitrate and nitrite sensing; Region: NIT; pfam08376 367737005698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737005699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005700 dimer interface [polypeptide binding]; other site 367737005701 putative CheW interface [polypeptide binding]; other site 367737005702 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 367737005703 arsenical pump membrane protein; Provisional; Region: PRK15445 367737005704 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 367737005705 transmembrane helices; other site 367737005706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367737005707 dimerization interface [polypeptide binding]; other site 367737005708 putative DNA binding site [nucleotide binding]; other site 367737005709 putative Zn2+ binding site [ion binding]; other site 367737005710 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 367737005711 Predicted permeases [General function prediction only]; Region: COG0701 367737005712 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 367737005713 Low molecular weight phosphatase family; Region: LMWPc; cd00115 367737005714 active site 367737005715 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 367737005716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737005717 H+ Antiporter protein; Region: 2A0121; TIGR00900 367737005718 putative substrate translocation pore; other site 367737005719 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 367737005720 FHIPEP family; Region: FHIPEP; pfam00771 367737005721 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 367737005722 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 367737005723 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 367737005724 Walker A motif/ATP binding site; other site 367737005725 Walker B motif; other site 367737005726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 367737005727 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 367737005728 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 367737005729 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 367737005730 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 367737005731 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 367737005732 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 367737005733 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737005734 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 367737005735 AAA domain; Region: AAA_31; pfam13614 367737005736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367737005737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367737005738 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 367737005739 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367737005740 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 367737005741 flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541 367737005742 flagellar motor switch protein FliY; Validated; Region: PRK08432 367737005743 flagellar motor switch protein FliN; Region: fliN; TIGR02480 367737005744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367737005745 binding surface 367737005746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 367737005747 TPR motif; other site 367737005748 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 367737005749 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 367737005750 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 367737005751 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737005752 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 367737005753 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737005754 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 367737005755 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 367737005756 Flagellar assembly protein FliH; Region: FliH; pfam02108 367737005757 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 367737005758 MgtE intracellular N domain; Region: MgtE_N; cl15244 367737005759 FliG C-terminal domain; Region: FliG_C; pfam01706 367737005760 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 367737005761 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 367737005762 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 367737005763 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 367737005764 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 367737005765 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 367737005766 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737005767 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 367737005768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737005769 active site 367737005770 phosphorylation site [posttranslational modification] 367737005771 intermolecular recognition site; other site 367737005772 dimerization interface [polypeptide binding]; other site 367737005773 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 367737005774 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 367737005775 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 367737005776 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 367737005777 RimM N-terminal domain; Region: RimM; pfam01782 367737005778 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 367737005779 KH domain; Region: KH_4; pfam13083 367737005780 G-X-X-G motif; other site 367737005781 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 367737005782 signal recognition particle protein; Provisional; Region: PRK10867 367737005783 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 367737005784 P loop; other site 367737005785 GTP binding site [chemical binding]; other site 367737005786 Signal peptide binding domain; Region: SRP_SPB; pfam02978 367737005787 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 367737005788 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 367737005789 active site 367737005790 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 367737005791 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 367737005792 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 367737005793 Putative zinc ribbon domain; Region: DUF164; pfam02591 367737005794 Uncharacterized conserved protein [Function unknown]; Region: COG0327 367737005795 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 367737005796 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 367737005797 dimer interface [polypeptide binding]; other site 367737005798 motif 1; other site 367737005799 active site 367737005800 motif 2; other site 367737005801 motif 3; other site 367737005802 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 367737005803 catalytic residues [active] 367737005804 AIR carboxylase; Region: AIRC; smart01001 367737005805 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 367737005806 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 367737005807 Peptidase family U32; Region: Peptidase_U32; pfam01136 367737005808 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 367737005809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 367737005810 dimerization interface [polypeptide binding]; other site 367737005811 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 367737005812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737005813 dimer interface [polypeptide binding]; other site 367737005814 putative CheW interface [polypeptide binding]; other site 367737005815 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 367737005816 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 367737005817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367737005818 Walker A/P-loop; other site 367737005819 ATP binding site [chemical binding]; other site 367737005820 Q-loop/lid; other site 367737005821 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 367737005822 ABC transporter signature motif; other site 367737005823 Walker B; other site 367737005824 D-loop; other site 367737005825 H-loop/switch region; other site 367737005826 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 367737005827 ATP-NAD kinase; Region: NAD_kinase; pfam01513 367737005828 elongation factor G; Reviewed; Region: PRK00007 367737005829 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 367737005830 G1 box; other site 367737005831 putative GEF interaction site [polypeptide binding]; other site 367737005832 GTP/Mg2+ binding site [chemical binding]; other site 367737005833 Switch I region; other site 367737005834 G2 box; other site 367737005835 G3 box; other site 367737005836 Switch II region; other site 367737005837 G4 box; other site 367737005838 G5 box; other site 367737005839 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 367737005840 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 367737005841 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 367737005842 30S ribosomal protein S7; Validated; Region: PRK05302 367737005843 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 367737005844 S17 interaction site [polypeptide binding]; other site 367737005845 S8 interaction site; other site 367737005846 16S rRNA interaction site [nucleotide binding]; other site 367737005847 streptomycin interaction site [chemical binding]; other site 367737005848 23S rRNA interaction site [nucleotide binding]; other site 367737005849 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 367737005850 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 367737005851 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367737005852 MFS transport protein AraJ; Provisional; Region: PRK10091 367737005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737005854 putative substrate translocation pore; other site 367737005855 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 367737005856 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737005857 N-terminal plug; other site 367737005858 ligand-binding site [chemical binding]; other site 367737005859 NMT1/THI5 like; Region: NMT1; pfam09084 367737005860 Protein of unknown function (DUF3834); Region: DUF3834; pfam12916 367737005861 NnrS protein; Region: NnrS; pfam05940 367737005862 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 367737005863 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 367737005864 Walker A/P-loop; other site 367737005865 ATP binding site [chemical binding]; other site 367737005866 Q-loop/lid; other site 367737005867 ABC transporter signature motif; other site 367737005868 Walker B; other site 367737005869 D-loop; other site 367737005870 H-loop/switch region; other site 367737005871 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 367737005872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737005873 dimer interface [polypeptide binding]; other site 367737005874 conserved gate region; other site 367737005875 putative PBP binding loops; other site 367737005876 ABC-ATPase subunit interface; other site 367737005877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 367737005878 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 367737005879 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 367737005880 glutamine binding [chemical binding]; other site 367737005881 catalytic triad [active] 367737005882 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 367737005883 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367737005884 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 367737005885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737005886 dimer interface [polypeptide binding]; other site 367737005887 conserved gate region; other site 367737005888 putative PBP binding loops; other site 367737005889 ABC-ATPase subunit interface; other site 367737005890 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 367737005891 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 367737005892 Walker A/P-loop; other site 367737005893 ATP binding site [chemical binding]; other site 367737005894 Q-loop/lid; other site 367737005895 ABC transporter signature motif; other site 367737005896 Walker B; other site 367737005897 D-loop; other site 367737005898 H-loop/switch region; other site 367737005899 TOBE domain; Region: TOBE_2; pfam08402 367737005900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737005901 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737005902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737005903 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737005904 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737005905 N-terminal plug; other site 367737005906 ligand-binding site [chemical binding]; other site 367737005907 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 367737005908 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 367737005909 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 367737005910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 367737005911 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 367737005912 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 367737005913 metal binding site [ion binding]; metal-binding site 367737005914 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 367737005915 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 367737005916 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 367737005917 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 367737005918 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 367737005919 RNA binding site [nucleotide binding]; other site 367737005920 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 367737005921 homotrimer interaction site [polypeptide binding]; other site 367737005922 putative active site [active] 367737005923 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 367737005924 nudix motif; other site 367737005925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737005926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737005927 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 367737005928 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 367737005929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737005930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737005931 homodimer interface [polypeptide binding]; other site 367737005932 catalytic residue [active] 367737005933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 367737005934 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 367737005935 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 367737005936 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 367737005937 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 367737005938 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 367737005939 THF binding site; other site 367737005940 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 367737005941 substrate binding site [chemical binding]; other site 367737005942 THF binding site; other site 367737005943 zinc-binding site [ion binding]; other site 367737005944 threonine dehydratase; Provisional; Region: PRK08526 367737005945 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 367737005946 tetramer interface [polypeptide binding]; other site 367737005947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737005948 catalytic residue [active] 367737005949 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 367737005950 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 367737005951 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 367737005952 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 367737005953 thiamine phosphate binding site [chemical binding]; other site 367737005954 active site 367737005955 pyrophosphate binding site [ion binding]; other site 367737005956 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 367737005957 Dihydroneopterin aldolase; Region: FolB; pfam02152 367737005958 active site 367737005959 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 367737005960 quinolinate synthetase; Provisional; Region: PRK09375 367737005961 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 367737005962 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 367737005963 dimerization interface [polypeptide binding]; other site 367737005964 active site 367737005965 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 367737005966 DHH family; Region: DHH; pfam01368 367737005967 DHHA1 domain; Region: DHHA1; pfam02272 367737005968 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 367737005969 Peptidase family M23; Region: Peptidase_M23; pfam01551 367737005970 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 367737005971 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 367737005972 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 367737005973 homoserine kinase; Provisional; Region: PRK01212 367737005974 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 367737005975 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 367737005976 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 367737005977 translation initiation factor IF-2; Region: IF-2; TIGR00487 367737005978 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 367737005979 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 367737005980 G1 box; other site 367737005981 putative GEF interaction site [polypeptide binding]; other site 367737005982 GTP/Mg2+ binding site [chemical binding]; other site 367737005983 Switch I region; other site 367737005984 G2 box; other site 367737005985 G3 box; other site 367737005986 Switch II region; other site 367737005987 G4 box; other site 367737005988 G5 box; other site 367737005989 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 367737005990 Translation-initiation factor 2; Region: IF-2; pfam11987 367737005991 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 367737005992 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 367737005993 ribosome maturation protein RimP; Reviewed; Region: PRK00092 367737005994 Sm and related proteins; Region: Sm_like; cl00259 367737005995 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 367737005996 putative oligomer interface [polypeptide binding]; other site 367737005997 putative RNA binding site [nucleotide binding]; other site 367737005998 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 367737005999 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 367737006000 catalytic motif [active] 367737006001 Zn binding site [ion binding]; other site 367737006002 RibD C-terminal domain; Region: RibD_C; cl17279 367737006003 elongation factor P; Validated; Region: PRK00529 367737006004 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 367737006005 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 367737006006 RNA binding site [nucleotide binding]; other site 367737006007 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 367737006008 RNA binding site [nucleotide binding]; other site 367737006009 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 367737006010 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 367737006011 ligand binding site [chemical binding]; other site 367737006012 NAD binding site [chemical binding]; other site 367737006013 dimerization interface [polypeptide binding]; other site 367737006014 catalytic site [active] 367737006015 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 367737006016 putative L-serine binding site [chemical binding]; other site 367737006017 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 367737006018 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 367737006019 RNA binding site [nucleotide binding]; other site 367737006020 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 367737006021 RNA binding site [nucleotide binding]; other site 367737006022 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 367737006023 RNA binding site [nucleotide binding]; other site 367737006024 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 367737006025 RNA binding site [nucleotide binding]; other site 367737006026 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 367737006027 RNA binding site [nucleotide binding]; other site 367737006028 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 367737006029 RNA binding site [nucleotide binding]; other site 367737006030 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 367737006031 LytB protein; Region: LYTB; pfam02401 367737006032 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 367737006033 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 367737006034 hinge; other site 367737006035 active site 367737006036 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 367737006037 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 367737006038 putative tRNA-binding site [nucleotide binding]; other site 367737006039 tRNA synthetase B5 domain; Region: B5; smart00874 367737006040 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 367737006041 dimer interface [polypeptide binding]; other site 367737006042 motif 1; other site 367737006043 motif 3; other site 367737006044 motif 2; other site 367737006045 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 367737006046 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 367737006047 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 367737006048 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 367737006049 dimer interface [polypeptide binding]; other site 367737006050 motif 1; other site 367737006051 active site 367737006052 motif 2; other site 367737006053 motif 3; other site 367737006054 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 367737006055 nucleotide binding site/active site [active] 367737006056 HIT family signature motif; other site 367737006057 catalytic residue [active] 367737006058 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 367737006059 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 367737006060 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 367737006061 dimer interface [polypeptide binding]; other site 367737006062 active site 367737006063 acyl carrier protein; Provisional; Region: acpP; PRK00982 367737006064 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 367737006065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737006066 NAD(P) binding site [chemical binding]; other site 367737006067 active site 367737006068 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 367737006069 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 367737006070 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 367737006071 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 367737006072 Ligand Binding Site [chemical binding]; other site 367737006073 RNA methyltransferase, RsmE family; Region: TIGR00046 367737006074 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 367737006075 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 367737006076 Cytochrome c; Region: Cytochrom_C; pfam00034 367737006077 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 367737006078 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 367737006079 intrachain domain interface; other site 367737006080 interchain domain interface [polypeptide binding]; other site 367737006081 heme bH binding site [chemical binding]; other site 367737006082 Qi binding site; other site 367737006083 heme bL binding site [chemical binding]; other site 367737006084 Qo binding site; other site 367737006085 interchain domain interface [polypeptide binding]; other site 367737006086 intrachain domain interface; other site 367737006087 Qi binding site; other site 367737006088 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 367737006089 Qo binding site; other site 367737006090 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 367737006091 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 367737006092 iron-sulfur cluster [ion binding]; other site 367737006093 [2Fe-2S] cluster binding site [ion binding]; other site 367737006094 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 367737006095 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 367737006096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006097 catalytic residue [active] 367737006098 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 367737006099 feedback inhibition sensing region; other site 367737006100 homohexameric interface [polypeptide binding]; other site 367737006101 nucleotide binding site [chemical binding]; other site 367737006102 N-acetyl-L-glutamate binding site [chemical binding]; other site 367737006103 putative recombination protein RecB; Provisional; Region: PRK13909 367737006104 Part of AAA domain; Region: AAA_19; pfam13245 367737006105 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 367737006106 Cytochrome c; Region: Cytochrom_C; cl11414 367737006107 peptide chain release factor 2; Validated; Region: prfB; PRK00578 367737006108 This domain is found in peptide chain release factors; Region: PCRF; smart00937 367737006109 RF-1 domain; Region: RF-1; pfam00472 367737006110 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 367737006111 dimer interface [polypeptide binding]; other site 367737006112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 367737006113 metal binding site [ion binding]; metal-binding site 367737006114 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 367737006115 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 367737006116 FixH; Region: FixH; pfam05751 367737006117 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 367737006118 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 367737006119 Cytochrome c; Region: Cytochrom_C; pfam00034 367737006120 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 367737006121 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 367737006122 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 367737006123 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 367737006124 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 367737006125 Low-spin heme binding site [chemical binding]; other site 367737006126 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 367737006127 D-pathway; other site 367737006128 Putative water exit pathway; other site 367737006129 Binuclear center (active site) [active] 367737006130 K-pathway; other site 367737006131 Putative proton exit pathway; other site 367737006132 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 367737006133 SmpB-tmRNA interface; other site 367737006134 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 367737006135 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 367737006136 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 367737006137 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 367737006138 active site 367737006139 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 367737006140 Part of AAA domain; Region: AAA_19; pfam13245 367737006141 Family description; Region: UvrD_C_2; pfam13538 367737006142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 367737006143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 367737006144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 367737006145 dimerization interface [polypeptide binding]; other site 367737006146 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 367737006147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737006148 amidophosphoribosyltransferase; Provisional; Region: PRK08525 367737006149 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 367737006150 active site 367737006151 tetramer interface [polypeptide binding]; other site 367737006152 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737006153 active site 367737006154 dihydrodipicolinate reductase; Provisional; Region: PRK00048 367737006155 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 367737006156 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 367737006157 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 367737006158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367737006159 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 367737006160 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 367737006161 catalytic residues [active] 367737006162 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 367737006163 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 367737006164 motif 1; other site 367737006165 active site 367737006166 motif 2; other site 367737006167 motif 3; other site 367737006168 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 367737006169 DHHA1 domain; Region: DHHA1; pfam02272 367737006170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 367737006171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737006172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737006173 putative substrate translocation pore; other site 367737006174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737006175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367737006176 dimer interface [polypeptide binding]; other site 367737006177 phosphorylation site [posttranslational modification] 367737006178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737006179 ATP binding site [chemical binding]; other site 367737006180 Mg2+ binding site [ion binding]; other site 367737006181 G-X-G motif; other site 367737006182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737006183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737006184 active site 367737006185 phosphorylation site [posttranslational modification] 367737006186 intermolecular recognition site; other site 367737006187 dimerization interface [polypeptide binding]; other site 367737006188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737006189 DNA binding site [nucleotide binding] 367737006190 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 367737006191 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 367737006192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 367737006193 protein binding site [polypeptide binding]; other site 367737006194 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 367737006195 protein binding site [polypeptide binding]; other site 367737006196 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 367737006197 Arcobacter butzleri genomic island 3 (ABGI3) 367737006198 integrase; Provisional; Region: PRK09692 367737006199 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 367737006200 active site 367737006201 Int/Topo IB signature motif; other site 367737006202 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 367737006203 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367737006204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367737006205 Walker A/P-loop; other site 367737006206 ATP binding site [chemical binding]; other site 367737006207 Q-loop/lid; other site 367737006208 ABC transporter signature motif; other site 367737006209 Walker B; other site 367737006210 D-loop; other site 367737006211 H-loop/switch region; other site 367737006212 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 367737006213 FtsX-like permease family; Region: FtsX; pfam02687 367737006214 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 367737006215 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 367737006216 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 367737006217 active site 367737006218 PQQ-like domain; Region: PQQ_2; pfam13360 367737006219 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 367737006220 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 367737006221 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 367737006222 protein binding site [polypeptide binding]; other site 367737006223 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 367737006224 Catalytic dyad [active] 367737006225 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 367737006226 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 367737006227 ATP binding site [chemical binding]; other site 367737006228 active site 367737006229 substrate binding site [chemical binding]; other site 367737006230 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 367737006231 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 367737006232 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 367737006233 putative active site [active] 367737006234 catalytic triad [active] 367737006235 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 367737006236 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 367737006237 putative acyl-acceptor binding pocket; other site 367737006238 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 367737006239 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 367737006240 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 367737006241 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 367737006242 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 367737006243 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 367737006244 active site 367737006245 HIGH motif; other site 367737006246 KMSK motif region; other site 367737006247 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 367737006248 tRNA binding surface [nucleotide binding]; other site 367737006249 anticodon binding site; other site 367737006250 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 367737006251 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 367737006252 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 367737006253 active site 367737006254 (T/H)XGH motif; other site 367737006255 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 367737006256 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 367737006257 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 367737006258 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 367737006259 Phosphoglycerate kinase; Region: PGK; pfam00162 367737006260 substrate binding site [chemical binding]; other site 367737006261 hinge regions; other site 367737006262 ADP binding site [chemical binding]; other site 367737006263 catalytic site [active] 367737006264 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 367737006265 triosephosphate isomerase; Provisional; Region: PRK14565 367737006266 substrate binding site [chemical binding]; other site 367737006267 dimer interface [polypeptide binding]; other site 367737006268 catalytic triad [active] 367737006269 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08415 367737006270 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 367737006271 NAD binding site [chemical binding]; other site 367737006272 homotetramer interface [polypeptide binding]; other site 367737006273 homodimer interface [polypeptide binding]; other site 367737006274 substrate binding site [chemical binding]; other site 367737006275 active site 367737006276 diaminopimelate decarboxylase; Region: lysA; TIGR01048 367737006277 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 367737006278 active site 367737006279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367737006280 substrate binding site [chemical binding]; other site 367737006281 catalytic residues [active] 367737006282 dimer interface [polypeptide binding]; other site 367737006283 Chorismate mutase type II; Region: CM_2; cl00693 367737006284 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 367737006285 Prephenate dehydratase; Region: PDT; pfam00800 367737006286 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 367737006287 putative L-Phe binding site [chemical binding]; other site 367737006288 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 367737006289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367737006290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006291 homodimer interface [polypeptide binding]; other site 367737006292 catalytic residue [active] 367737006293 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 367737006294 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 367737006295 TPP-binding site; other site 367737006296 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 367737006297 PYR/PP interface [polypeptide binding]; other site 367737006298 dimer interface [polypeptide binding]; other site 367737006299 TPP binding site [chemical binding]; other site 367737006300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 367737006301 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 367737006302 Maf-like protein; Reviewed; Region: PRK04056 367737006303 Maf-like protein; Region: Maf; pfam02545 367737006304 putative active site [active] 367737006305 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 367737006306 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 367737006307 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 367737006308 NlpC/P60 family; Region: NLPC_P60; pfam00877 367737006309 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 367737006310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367737006311 ligand binding site [chemical binding]; other site 367737006312 flexible hinge region; other site 367737006313 putative switch regulator; other site 367737006314 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 367737006315 non-specific DNA interactions [nucleotide binding]; other site 367737006316 DNA binding site [nucleotide binding] 367737006317 sequence specific DNA binding site [nucleotide binding]; other site 367737006318 putative cAMP binding site [chemical binding]; other site 367737006319 hypothetical protein; Provisional; Region: PRK10410 367737006320 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 367737006321 ligand binding site [chemical binding]; other site 367737006322 active site 367737006323 UGI interface [polypeptide binding]; other site 367737006324 catalytic site [active] 367737006325 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 367737006326 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 367737006327 NAD(P) binding site [chemical binding]; other site 367737006328 catalytic residues [active] 367737006329 acetolactate synthase; Reviewed; Region: PRK08322 367737006330 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 367737006331 PYR/PP interface [polypeptide binding]; other site 367737006332 dimer interface [polypeptide binding]; other site 367737006333 TPP binding site [chemical binding]; other site 367737006334 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 367737006335 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 367737006336 TPP-binding site [chemical binding]; other site 367737006337 dimer interface [polypeptide binding]; other site 367737006338 LemA family; Region: LemA; cl00742 367737006339 Repair protein; Region: Repair_PSII; cl01535 367737006340 Repair protein; Region: Repair_PSII; pfam04536 367737006341 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 367737006342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367737006343 motif II; other site 367737006344 Ferritin-like domain; Region: Ferritin; pfam00210 367737006345 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 367737006346 dimerization interface [polypeptide binding]; other site 367737006347 DPS ferroxidase diiron center [ion binding]; other site 367737006348 ion pore; other site 367737006349 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 367737006350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737006351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737006352 putative substrate translocation pore; other site 367737006353 HAMP domain; Region: HAMP; pfam00672 367737006354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737006355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737006356 metal binding site [ion binding]; metal-binding site 367737006357 active site 367737006358 I-site; other site 367737006359 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 367737006360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737006361 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737006362 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 367737006363 Protein export membrane protein; Region: SecD_SecF; cl14618 367737006364 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 367737006365 Secretin and TonB N terminus short domain; Region: STN; smart00965 367737006366 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737006367 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737006368 N-terminal plug; other site 367737006369 ligand-binding site [chemical binding]; other site 367737006370 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737006371 FecR protein; Region: FecR; pfam04773 367737006372 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 367737006373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737006374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737006375 DNA binding residues [nucleotide binding] 367737006376 flavoprotein, HI0933 family; Region: TIGR00275 367737006377 Cupin domain; Region: Cupin_2; pfam07883 367737006378 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 367737006379 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367737006380 homodimer interface [polypeptide binding]; other site 367737006381 substrate-cofactor binding pocket; other site 367737006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006383 catalytic residue [active] 367737006384 Transcriptional regulator; Region: Rrf2; pfam02082 367737006385 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 367737006386 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 367737006387 dimer interface [polypeptide binding]; other site 367737006388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006389 catalytic residue [active] 367737006390 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 367737006391 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 367737006392 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 367737006393 Active Sites [active] 367737006394 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 367737006395 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 367737006396 Active Sites [active] 367737006397 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 367737006398 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 367737006399 CysD dimerization site [polypeptide binding]; other site 367737006400 G1 box; other site 367737006401 putative GEF interaction site [polypeptide binding]; other site 367737006402 GTP/Mg2+ binding site [chemical binding]; other site 367737006403 Switch I region; other site 367737006404 G2 box; other site 367737006405 G3 box; other site 367737006406 Switch II region; other site 367737006407 G4 box; other site 367737006408 G5 box; other site 367737006409 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 367737006410 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 367737006411 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 367737006412 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 367737006413 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 367737006414 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 367737006415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367737006416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367737006417 catalytic residue [active] 367737006418 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 367737006419 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 367737006420 metal ion-dependent adhesion site (MIDAS); other site 367737006421 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367737006422 cobalamin synthase; Reviewed; Region: cobS; PRK00235 367737006423 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 367737006424 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 367737006425 active site 367737006426 catalytic triad [active] 367737006427 oxyanion hole [active] 367737006428 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 367737006429 putative dimer interface [polypeptide binding]; other site 367737006430 active site pocket [active] 367737006431 putative cataytic base [active] 367737006432 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 367737006433 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 367737006434 transmembrane helices; other site 367737006435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367737006436 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 367737006437 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 367737006438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737006439 putative substrate translocation pore; other site 367737006440 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 367737006441 DsbD alpha interface [polypeptide binding]; other site 367737006442 catalytic residues [active] 367737006443 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 367737006444 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367737006445 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 367737006446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737006447 metal binding site [ion binding]; metal-binding site 367737006448 active site 367737006449 I-site; other site 367737006450 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737006451 phosphatidylserine decarboxylase; Provisional; Region: PRK03934 367737006452 MltA specific insert domain; Region: MltA; smart00925 367737006453 3D domain; Region: 3D; pfam06725 367737006454 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 367737006455 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 367737006456 nucleotide binding site [chemical binding]; other site 367737006457 NEF interaction site [polypeptide binding]; other site 367737006458 SBD interface [polypeptide binding]; other site 367737006459 GrpE; Region: GrpE; pfam01025 367737006460 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 367737006461 dimer interface [polypeptide binding]; other site 367737006462 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 367737006463 heat-inducible transcription repressor; Provisional; Region: PRK03911 367737006464 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 367737006465 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 367737006466 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 367737006467 dimerization interface 3.5A [polypeptide binding]; other site 367737006468 active site 367737006469 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 367737006470 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 367737006471 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14833 367737006472 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 367737006473 catalytic residue [active] 367737006474 putative FPP diphosphate binding site; other site 367737006475 putative FPP binding hydrophobic cleft; other site 367737006476 dimer interface [polypeptide binding]; other site 367737006477 putative IPP diphosphate binding site; other site 367737006478 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 367737006479 Flavoprotein; Region: Flavoprotein; pfam02441 367737006480 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 367737006481 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 367737006482 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 367737006483 Substrate binding site; other site 367737006484 Mg++ binding site; other site 367737006485 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 367737006486 active site 367737006487 substrate binding site [chemical binding]; other site 367737006488 CoA binding site [chemical binding]; other site 367737006489 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006490 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 367737006491 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006492 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737006493 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737006494 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006495 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006496 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737006497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006498 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737006499 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 367737006500 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 367737006501 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 367737006502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367737006503 nucleotide binding region [chemical binding]; other site 367737006504 ATP-binding site [chemical binding]; other site 367737006505 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 367737006506 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 367737006507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737006508 S-adenosylmethionine binding site [chemical binding]; other site 367737006509 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 367737006510 nudix motif; other site 367737006511 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 367737006512 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 367737006513 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 367737006514 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 367737006515 Lumazine binding domain; Region: Lum_binding; pfam00677 367737006516 Lumazine binding domain; Region: Lum_binding; pfam00677 367737006517 rod shape-determining protein MreC; Provisional; Region: PRK13922 367737006518 rod shape-determining protein MreC; Region: MreC; pfam04085 367737006519 rod shape-determining protein MreB; Provisional; Region: PRK13927 367737006520 MreB and similar proteins; Region: MreB_like; cd10225 367737006521 nucleotide binding site [chemical binding]; other site 367737006522 Mg binding site [ion binding]; other site 367737006523 putative protofilament interaction site [polypeptide binding]; other site 367737006524 RodZ interaction site [polypeptide binding]; other site 367737006525 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 367737006526 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 367737006527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367737006528 Walker A motif; other site 367737006529 ATP binding site [chemical binding]; other site 367737006530 Walker B motif; other site 367737006531 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 367737006532 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 367737006533 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 367737006534 active site 367737006535 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 367737006536 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 367737006537 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 367737006538 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 367737006539 Ligand Binding Site [chemical binding]; other site 367737006540 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 367737006541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367737006542 endonuclease IV; Provisional; Region: PRK01060 367737006543 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 367737006544 AP (apurinic/apyrimidinic) site pocket; other site 367737006545 DNA interaction; other site 367737006546 Metal-binding active site; metal-binding site 367737006547 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 367737006548 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 367737006549 Protein export membrane protein; Region: SecD_SecF; cl14618 367737006550 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 367737006551 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 367737006552 HlyD family secretion protein; Region: HlyD_3; pfam13437 367737006553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367737006554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367737006555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367737006556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367737006557 putative substrate translocation pore; other site 367737006558 putative transporter; Provisional; Region: PRK11660 367737006559 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 367737006560 Sulfate transporter family; Region: Sulfate_transp; pfam00916 367737006561 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 367737006562 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 367737006563 Sel1 repeat; Region: Sel1; cl02723 367737006564 Sel1-like repeats; Region: SEL1; smart00671 367737006565 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 367737006566 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 367737006567 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 367737006568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367737006569 active site 367737006570 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 367737006571 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 367737006572 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 367737006573 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 367737006574 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 367737006575 active site 367737006576 metal binding site [ion binding]; metal-binding site 367737006577 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 367737006578 domain I; other site 367737006579 DNA binding groove [nucleotide binding] 367737006580 phosphate binding site [ion binding]; other site 367737006581 domain II; other site 367737006582 domain III; other site 367737006583 nucleotide binding site [chemical binding]; other site 367737006584 catalytic site [active] 367737006585 domain IV; other site 367737006586 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 367737006587 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 367737006588 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 367737006589 active site 367737006590 metal binding site [ion binding]; metal-binding site 367737006591 homotetramer interface [polypeptide binding]; other site 367737006592 biotin synthase; Provisional; Region: PRK08508 367737006593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367737006594 FeS/SAM binding site; other site 367737006595 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 367737006596 AMIN domain; Region: AMIN; pfam11741 367737006597 enolase; Provisional; Region: eno; PRK00077 367737006598 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 367737006599 dimer interface [polypeptide binding]; other site 367737006600 metal binding site [ion binding]; metal-binding site 367737006601 substrate binding pocket [chemical binding]; other site 367737006602 recombinase A; Provisional; Region: recA; PRK09354 367737006603 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 367737006604 hexamer interface [polypeptide binding]; other site 367737006605 Walker A motif; other site 367737006606 ATP binding site [chemical binding]; other site 367737006607 Walker B motif; other site 367737006608 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 367737006609 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 367737006610 NAD(P) binding site [chemical binding]; other site 367737006611 homodimer interface [polypeptide binding]; other site 367737006612 substrate binding site [chemical binding]; other site 367737006613 active site 367737006614 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 367737006615 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 367737006616 inhibitor-cofactor binding pocket; inhibition site 367737006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006618 catalytic residue [active] 367737006619 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 367737006620 ligand binding site; other site 367737006621 tetramer interface; other site 367737006622 pseudaminic acid synthase; Region: PseI; TIGR03586 367737006623 NeuB family; Region: NeuB; pfam03102 367737006624 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 367737006625 NeuB binding interface [polypeptide binding]; other site 367737006626 putative substrate binding site [chemical binding]; other site 367737006627 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 367737006628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367737006629 Methyltransferase domain; Region: Methyltransf_23; pfam13489 367737006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737006631 S-adenosylmethionine binding site [chemical binding]; other site 367737006632 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 367737006633 LicD family; Region: LicD; pfam04991 367737006634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737006635 S-adenosylmethionine binding site [chemical binding]; other site 367737006636 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 367737006637 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 367737006638 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 367737006639 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 367737006640 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 367737006641 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 367737006642 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 367737006643 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 367737006644 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 367737006645 4Fe-4S binding domain; Region: Fer4_5; pfam12801 367737006646 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 367737006647 CTP synthetase; Validated; Region: pyrG; PRK05380 367737006648 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 367737006649 Catalytic site [active] 367737006650 active site 367737006651 UTP binding site [chemical binding]; other site 367737006652 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 367737006653 active site 367737006654 putative oxyanion hole; other site 367737006655 catalytic triad [active] 367737006656 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 367737006657 DHH family; Region: DHH; pfam01368 367737006658 DHHA1 domain; Region: DHHA1; pfam02272 367737006659 Predicted integral membrane protein [Function unknown]; Region: COG5616 367737006660 DJ-1 family protein; Region: not_thiJ; TIGR01383 367737006661 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 367737006662 conserved cys residue [active] 367737006663 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 367737006664 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 367737006665 active site 367737006666 PHP Thumb interface [polypeptide binding]; other site 367737006667 metal binding site [ion binding]; metal-binding site 367737006668 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 367737006669 generic binding surface II; other site 367737006670 generic binding surface I; other site 367737006671 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 367737006672 Protein of unknown function (DUF493); Region: DUF493; pfam04359 367737006673 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 367737006674 trimer interface [polypeptide binding]; other site 367737006675 dimer interface [polypeptide binding]; other site 367737006676 putative active site [active] 367737006677 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 367737006678 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 367737006679 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 367737006680 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 367737006681 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 367737006682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737006683 S-adenosylmethionine binding site [chemical binding]; other site 367737006684 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 367737006685 ribosome recycling factor; Reviewed; Region: frr; PRK00083 367737006686 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 367737006687 hinge region; other site 367737006688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367737006689 active site 367737006690 RDD family; Region: RDD; pfam06271 367737006691 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 367737006692 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 367737006693 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 367737006694 Cl binding site [ion binding]; other site 367737006695 oligomer interface [polypeptide binding]; other site 367737006696 Protein of unknown function (DUF328); Region: DUF328; pfam03883 367737006697 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 367737006698 Helix-hairpin-helix motif; Region: HHH; pfam00633 367737006699 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 367737006700 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 367737006701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 367737006702 putative active site [active] 367737006703 putative metal binding site [ion binding]; other site 367737006704 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 367737006705 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 367737006706 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737006707 N-terminal plug; other site 367737006708 ligand-binding site [chemical binding]; other site 367737006709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 367737006710 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 367737006711 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 367737006712 putative dimer interface [polypeptide binding]; other site 367737006713 Hemerythrin; Region: Hemerythrin; cd12107 367737006714 Fe binding site [ion binding]; other site 367737006715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 367737006716 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 367737006717 dimer interface [polypeptide binding]; other site 367737006718 putative CheW interface [polypeptide binding]; other site 367737006719 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 367737006720 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 367737006721 ATP binding site [chemical binding]; other site 367737006722 substrate interface [chemical binding]; other site 367737006723 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 367737006724 active site residue [active] 367737006725 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367737006726 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 367737006727 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367737006728 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 367737006729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 367737006730 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 367737006731 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 367737006732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 367737006733 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367737006734 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 367737006735 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367737006736 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 367737006737 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 367737006738 Walker A/P-loop; other site 367737006739 ATP binding site [chemical binding]; other site 367737006740 Q-loop/lid; other site 367737006741 ABC transporter signature motif; other site 367737006742 Walker B; other site 367737006743 D-loop; other site 367737006744 H-loop/switch region; other site 367737006745 TOBE-like domain; Region: TOBE_3; pfam12857 367737006746 sulfate transport protein; Provisional; Region: cysT; CHL00187 367737006747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737006748 dimer interface [polypeptide binding]; other site 367737006749 conserved gate region; other site 367737006750 putative PBP binding loops; other site 367737006751 ABC-ATPase subunit interface; other site 367737006752 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 367737006753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367737006754 dimer interface [polypeptide binding]; other site 367737006755 conserved gate region; other site 367737006756 putative PBP binding loops; other site 367737006757 ABC-ATPase subunit interface; other site 367737006758 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 367737006759 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 367737006760 dimer interface [polypeptide binding]; other site 367737006761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367737006762 catalytic residue [active] 367737006763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737006764 metal binding site [ion binding]; metal-binding site 367737006765 active site 367737006766 I-site; other site 367737006767 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 367737006768 Ubiquitin-like proteins; Region: UBQ; cl00155 367737006769 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 367737006770 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 367737006771 Rrf2 family protein; Region: rrf2_super; TIGR00738 367737006772 Transcriptional regulator; Region: Rrf2; pfam02082 367737006773 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 367737006774 putative active site [active] 367737006775 Zn binding site [ion binding]; other site 367737006776 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 367737006777 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 367737006778 putative active site [active] 367737006779 Zn binding site [ion binding]; other site 367737006780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 367737006781 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 367737006782 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 367737006783 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 367737006784 G1 box; other site 367737006785 putative GEF interaction site [polypeptide binding]; other site 367737006786 GTP/Mg2+ binding site [chemical binding]; other site 367737006787 Switch I region; other site 367737006788 G2 box; other site 367737006789 G3 box; other site 367737006790 Switch II region; other site 367737006791 G4 box; other site 367737006792 G5 box; other site 367737006793 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 367737006794 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 367737006795 putative inner membrane protein; Provisional; Region: PRK11099 367737006796 hypothetical protein; Provisional; Region: PRK11018 367737006797 CPxP motif; other site 367737006798 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 367737006799 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 367737006800 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 367737006801 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 367737006802 N-terminal plug; other site 367737006803 ligand-binding site [chemical binding]; other site 367737006804 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 367737006805 FecR protein; Region: FecR; pfam04773 367737006806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 367737006807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367737006808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367737006809 DNA binding residues [nucleotide binding] 367737006810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737006811 PAS fold; Region: PAS_3; pfam08447 367737006812 putative active site [active] 367737006813 heme pocket [chemical binding]; other site 367737006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737006815 putative active site [active] 367737006816 PAS fold; Region: PAS_3; pfam08447 367737006817 heme pocket [chemical binding]; other site 367737006818 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 367737006819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737006820 putative active site [active] 367737006821 heme pocket [chemical binding]; other site 367737006822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 367737006823 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 367737006824 putative active site [active] 367737006825 heme pocket [chemical binding]; other site 367737006826 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 367737006827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 367737006828 metal binding site [ion binding]; metal-binding site 367737006829 active site 367737006830 I-site; other site 367737006831 putative metal dependent hydrolase; Provisional; Region: PRK11598 367737006832 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 367737006833 Sulfatase; Region: Sulfatase; pfam00884 367737006834 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 367737006835 active site 367737006836 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 367737006837 Dihaem cytochrome c; Region: DHC; pfam09626 367737006838 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 367737006839 Dihaem cytochrome c; Region: DHC; pfam09626 367737006840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367737006841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367737006842 active site 367737006843 phosphorylation site [posttranslational modification] 367737006844 intermolecular recognition site; other site 367737006845 dimerization interface [polypeptide binding]; other site 367737006846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367737006847 DNA binding site [nucleotide binding] 367737006848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367737006849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 367737006850 dimerization interface [polypeptide binding]; other site 367737006851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367737006852 ATP binding site [chemical binding]; other site 367737006853 Mg2+ binding site [ion binding]; other site 367737006854 G-X-G motif; other site 367737006855 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 367737006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367737006857 S-adenosylmethionine binding site [chemical binding]; other site 367737006858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367737006859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367737006860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367737006861 Zn2+ binding site [ion binding]; other site 367737006862 Mg2+ binding site [ion binding]; other site 367737006863 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 367737006864 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 367737006865 glutaminase; Provisional; Region: PRK00971 367737006866 Predicted membrane protein [Function unknown]; Region: COG2860 367737006867 UPF0126 domain; Region: UPF0126; pfam03458 367737006868 UPF0126 domain; Region: UPF0126; pfam03458 367737006869 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 367737006870 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 367737006871 active site 367737006872 substrate binding site [chemical binding]; other site 367737006873 cosubstrate binding site; other site 367737006874 catalytic site [active] 367737006875 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 367737006876 active site 367737006877 putative DNA-binding cleft [nucleotide binding]; other site 367737006878 dimer interface [polypeptide binding]; other site