-- dump date 20140618_205144 -- class Genbank::misc_feature -- table misc_feature_note -- id note 861360000001 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360000002 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360000003 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 861360000004 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 861360000005 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360000006 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 861360000007 catalytic residues [active] 861360000008 catalytic nucleophile [active] 861360000009 Single-strand binding protein family; Region: SSB; pfam00436 861360000010 generic binding surface II; other site 861360000011 generic binding surface I; other site 861360000012 C-terminal section of a putative plasmid partition protein 861360000013 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 861360000014 Helix-turn-helix domain; Region: HTH_17; cl17695 861360000015 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 861360000016 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 861360000017 active site 861360000018 DNA binding site [nucleotide binding] 861360000019 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 861360000020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 861360000021 Catalytic site [active] 861360000022 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 861360000023 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 861360000024 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 861360000025 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 861360000026 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 861360000027 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 861360000028 HsdM N-terminal domain; Region: HsdM_N; pfam12161 861360000029 Methyltransferase domain; Region: Methyltransf_26; pfam13659 861360000030 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360000031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360000032 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360000033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360000034 Transposase; Region: HTH_Tnp_1; pfam01527 861360000035 putative transposase OrfB; Reviewed; Region: PHA02517 861360000036 HTH-like domain; Region: HTH_21; pfam13276 861360000037 Integrase core domain; Region: rve; pfam00665 861360000038 Integrase core domain; Region: rve_3; pfam13683 861360000040 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360000041 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360000042 catalytic residues [active] 861360000043 catalytic nucleophile [active] 861360000044 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360000045 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360000046 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360000047 Synaptic Site I dimer interface [polypeptide binding]; other site 861360000048 DNA binding site [nucleotide binding] 861360000049 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360000050 DNA-binding interface [nucleotide binding]; DNA binding site 861360000051 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360000052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360000053 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360000054 Protein of unknown function DUF262; Region: DUF262; pfam03235 861360000055 Uncharacterized conserved protein [Function unknown]; Region: COG1479 861360000056 Fic/DOC family; Region: Fic; cl00960 861360000057 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360000058 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360000059 catalytic residues [active] 861360000060 catalytic nucleophile [active] 861360000061 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360000062 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360000063 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360000064 Synaptic Site I dimer interface [polypeptide binding]; other site 861360000065 DNA binding site [nucleotide binding] 861360000066 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360000067 DNA-binding interface [nucleotide binding]; DNA binding site 861360000068 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 861360000069 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 861360000070 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 861360000071 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 861360000072 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 861360000073 AAA-like domain; Region: AAA_10; pfam12846 861360000074 Helix-turn-helix domain; Region: HTH_17; pfam12728 861360000075 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360000076 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360000077 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 861360000078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360000079 P-loop; other site 861360000080 Magnesium ion binding site [ion binding]; other site 861360000081 possible N-terminal section of a plasmidic protein 861360000082 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 861360000083 nucleotide binding site [chemical binding]; other site 861360000084 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 861360000085 Domain of unknown function (DUF955); Region: DUF955; pfam06114 861360000086 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 861360000087 catalytic residues [active] 861360000088 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 861360000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360000090 Walker A motif; other site 861360000091 ATP binding site [chemical binding]; other site 861360000092 Walker B motif; other site 861360000093 arginine finger; other site 861360000094 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 861360000095 DnaA box-binding interface [nucleotide binding]; other site 861360000096 DNA polymerase III subunit beta; Validated; Region: PRK07761 861360000097 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 861360000098 putative DNA binding surface [nucleotide binding]; other site 861360000099 dimer interface [polypeptide binding]; other site 861360000100 beta-clamp/clamp loader binding surface; other site 861360000101 beta-clamp/translesion DNA polymerase binding surface; other site 861360000102 recombination protein F; Reviewed; Region: recF; PRK00064 861360000103 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 861360000104 Walker A/P-loop; other site 861360000105 ATP binding site [chemical binding]; other site 861360000106 Q-loop/lid; other site 861360000107 ABC transporter signature motif; other site 861360000108 D-loop; other site 861360000109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360000110 ABC transporter signature motif; other site 861360000111 Walker B; other site 861360000112 D-loop; other site 861360000113 H-loop/switch region; other site 861360000114 Protein of unknown function (DUF721); Region: DUF721; cl02324 861360000115 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 861360000116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360000117 Mg2+ binding site [ion binding]; other site 861360000118 G-X-G motif; other site 861360000119 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 861360000120 anchoring element; other site 861360000121 dimer interface [polypeptide binding]; other site 861360000122 ATP binding site [chemical binding]; other site 861360000123 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 861360000124 active site 861360000125 putative metal-binding site [ion binding]; other site 861360000126 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 861360000127 DNA gyrase subunit A; Validated; Region: PRK05560 861360000128 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 861360000129 CAP-like domain; other site 861360000130 active site 861360000131 primary dimer interface [polypeptide binding]; other site 861360000132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360000138 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 861360000139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360000140 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 861360000141 bile acid transporter; Region: bass; TIGR00841 861360000142 Sodium Bile acid symporter family; Region: SBF; cl17470 861360000143 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 861360000144 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 861360000145 active site 861360000146 Rhomboid family; Region: Rhomboid; pfam01694 861360000147 Lysine efflux permease [General function prediction only]; Region: COG1279 861360000148 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 861360000149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360000150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 861360000151 dimerization interface [polypeptide binding]; other site 861360000152 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 861360000153 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 861360000154 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 861360000155 active site 861360000156 catalytic site [active] 861360000157 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 861360000158 Glutamine amidotransferase class-I; Region: GATase; pfam00117 861360000159 glutamine binding [chemical binding]; other site 861360000160 catalytic triad [active] 861360000161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 861360000162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360000163 Coenzyme A binding pocket [chemical binding]; other site 861360000164 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 861360000165 nudix motif; other site 861360000166 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360000167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360000168 active site 861360000169 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 861360000170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 861360000171 active site 861360000172 ATP binding site [chemical binding]; other site 861360000173 substrate binding site [chemical binding]; other site 861360000174 activation loop (A-loop); other site 861360000175 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360000176 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360000177 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360000178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 861360000179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 861360000180 active site 861360000181 ATP binding site [chemical binding]; other site 861360000182 substrate binding site [chemical binding]; other site 861360000183 activation loop (A-loop); other site 861360000184 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360000185 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360000186 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 861360000187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 861360000188 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 861360000189 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 861360000190 active site 861360000191 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 861360000192 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 861360000193 phosphopeptide binding site; other site 861360000194 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 861360000195 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 861360000196 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 861360000197 phosphopeptide binding site; other site 861360000198 Uncharacterized conserved protein [Function unknown]; Region: COG1683 861360000199 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 861360000200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360000201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360000202 DNA binding site [nucleotide binding] 861360000203 domain linker motif; other site 861360000204 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 861360000205 dimerization interface [polypeptide binding]; other site 861360000206 ligand binding site [chemical binding]; other site 861360000207 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 861360000208 active site 861360000209 tetramer interface [polypeptide binding]; other site 861360000210 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 861360000211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 861360000212 Ligand Binding Site [chemical binding]; other site 861360000213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360000214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 861360000215 dimerization interface [polypeptide binding]; other site 861360000216 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 861360000217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360000218 substrate binding site [chemical binding]; other site 861360000219 oxyanion hole (OAH) forming residues; other site 861360000220 trimer interface [polypeptide binding]; other site 861360000221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 861360000222 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 861360000223 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 861360000224 putative substrate binding site [chemical binding]; other site 861360000225 putative ATP binding site [chemical binding]; other site 861360000226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000227 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 861360000228 active site 861360000229 motif I; other site 861360000230 motif II; other site 861360000231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000232 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 861360000233 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 861360000234 active site 861360000235 catalytic site [active] 861360000236 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 861360000237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000238 motif II; other site 861360000239 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 861360000240 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 861360000241 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 861360000242 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 861360000243 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 861360000244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360000245 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 861360000246 putative substrate translocation pore; other site 861360000247 uracil transporter; Provisional; Region: PRK10720 861360000248 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 861360000249 dimer interface [polypeptide binding]; other site 861360000250 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 861360000251 substrate binding site [chemical binding]; other site 861360000252 ATP binding site [chemical binding]; other site 861360000253 Putative transcription activator [Transcription]; Region: TenA; COG0819 861360000254 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 861360000255 thiamine phosphate binding site [chemical binding]; other site 861360000256 active site 861360000257 pyrophosphate binding site [ion binding]; other site 861360000258 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 861360000259 substrate binding site [chemical binding]; other site 861360000260 multimerization interface [polypeptide binding]; other site 861360000261 ATP binding site [chemical binding]; other site 861360000262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360000263 DNA-binding site [nucleotide binding]; DNA binding site 861360000264 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 861360000265 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 861360000266 NAD(P) binding site [chemical binding]; other site 861360000267 catalytic residues [active] 861360000268 lysine transporter; Provisional; Region: PRK10836 861360000269 phosphoglucomutase; Validated; Region: PRK07564 861360000270 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 861360000271 active site 861360000272 substrate binding site [chemical binding]; other site 861360000273 metal binding site [ion binding]; metal-binding site 861360000274 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 861360000275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360000276 putative substrate translocation pore; other site 861360000277 POT family; Region: PTR2; cl17359 861360000278 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 861360000279 Amidase; Region: Amidase; cl11426 861360000280 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 861360000281 active site residue [active] 861360000282 prephenate dehydratase; Provisional; Region: PRK11898 861360000283 Prephenate dehydratase; Region: PDT; pfam00800 861360000284 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 861360000285 putative L-Phe binding site [chemical binding]; other site 861360000286 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 861360000287 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 861360000288 seryl-tRNA synthetase; Provisional; Region: PRK05431 861360000289 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 861360000290 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 861360000291 dimer interface [polypeptide binding]; other site 861360000292 active site 861360000293 motif 1; other site 861360000294 motif 2; other site 861360000295 motif 3; other site 861360000296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 861360000297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000298 active site 861360000299 motif I; other site 861360000300 motif II; other site 861360000301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000302 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 861360000303 putative substrate binding pocket [chemical binding]; other site 861360000304 AC domain interface; other site 861360000305 catalytic triad [active] 861360000306 AB domain interface; other site 861360000307 interchain disulfide; other site 861360000308 RmuC family; Region: RmuC; pfam02646 861360000309 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 861360000310 dimer interface [polypeptide binding]; other site 861360000311 substrate binding site [chemical binding]; other site 861360000312 metal binding sites [ion binding]; metal-binding site 861360000313 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 861360000314 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 861360000315 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 861360000316 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 861360000317 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 861360000318 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 861360000319 Ligand Binding Site [chemical binding]; other site 861360000320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360000321 active site 861360000322 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 861360000323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360000324 Walker A motif; other site 861360000325 ATP binding site [chemical binding]; other site 861360000326 Walker B motif; other site 861360000327 arginine finger; other site 861360000328 Peptidase family M41; Region: Peptidase_M41; pfam01434 861360000329 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 861360000330 homodecamer interface [polypeptide binding]; other site 861360000331 GTP cyclohydrolase I; Provisional; Region: PLN03044 861360000332 active site 861360000333 putative catalytic site residues [active] 861360000334 zinc binding site [ion binding]; other site 861360000335 GTP-CH-I/GFRP interaction surface; other site 861360000336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 861360000337 dihydropteroate synthase; Region: DHPS; TIGR01496 861360000338 substrate binding pocket [chemical binding]; other site 861360000339 dimer interface [polypeptide binding]; other site 861360000340 inhibitor binding site; inhibition site 861360000341 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 861360000342 homooctamer interface [polypeptide binding]; other site 861360000343 active site 861360000344 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 861360000345 catalytic center binding site [active] 861360000346 ATP binding site [chemical binding]; other site 861360000347 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 861360000348 Bacterial PH domain; Region: DUF304; cl01348 861360000349 Predicted membrane protein [Function unknown]; Region: COG3428 861360000350 Bacterial PH domain; Region: DUF304; pfam03703 861360000351 Bacterial PH domain; Region: DUF304; cl01348 861360000352 Bacterial PH domain; Region: DUF304; pfam03703 861360000353 Rossmann-like domain; Region: Rossmann-like; pfam10727 861360000354 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 861360000355 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 861360000356 pantoate--beta-alanine ligase; Region: panC; TIGR00018 861360000357 active site 861360000358 nucleotide binding site [chemical binding]; other site 861360000359 HIGH motif; other site 861360000360 KMSKS motif; other site 861360000361 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 861360000362 FMN binding site [chemical binding]; other site 861360000363 substrate binding site [chemical binding]; other site 861360000364 putative catalytic residue [active] 861360000365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360000366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360000367 non-specific DNA binding site [nucleotide binding]; other site 861360000368 salt bridge; other site 861360000369 sequence-specific DNA binding site [nucleotide binding]; other site 861360000370 HipA N-terminal domain; Region: Couple_hipA; pfam13657 861360000371 HipA-like N-terminal domain; Region: HipA_N; pfam07805 861360000372 HipA-like C-terminal domain; Region: HipA_C; pfam07804 861360000373 MepB protein; Region: MepB; cl01985 861360000374 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 861360000375 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 861360000376 active site 861360000377 Zn binding site [ion binding]; other site 861360000378 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 861360000379 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 861360000380 dimer interface [polypeptide binding]; other site 861360000381 putative anticodon binding site; other site 861360000382 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 861360000383 motif 1; other site 861360000384 dimer interface [polypeptide binding]; other site 861360000385 active site 861360000386 motif 2; other site 861360000387 motif 3; other site 861360000388 Lsr2; Region: Lsr2; pfam11774 861360000389 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 861360000390 Clp amino terminal domain; Region: Clp_N; pfam02861 861360000391 Clp amino terminal domain; Region: Clp_N; pfam02861 861360000392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360000393 Walker A motif; other site 861360000394 ATP binding site [chemical binding]; other site 861360000395 Walker B motif; other site 861360000396 arginine finger; other site 861360000397 UvrB/uvrC motif; Region: UVR; pfam02151 861360000398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360000399 Walker A motif; other site 861360000400 ATP binding site [chemical binding]; other site 861360000401 Walker B motif; other site 861360000402 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 861360000403 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 861360000404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360000405 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 861360000406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360000407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 861360000408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360000409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360000410 putative substrate translocation pore; other site 861360000411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360000412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360000413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360000414 Coenzyme A binding pocket [chemical binding]; other site 861360000415 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 861360000416 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 861360000417 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 861360000418 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 861360000419 endonuclease III; Region: ENDO3c; smart00478 861360000420 minor groove reading motif; other site 861360000421 helix-hairpin-helix signature motif; other site 861360000422 substrate binding pocket [chemical binding]; other site 861360000423 active site 861360000424 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 861360000425 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 861360000426 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 861360000427 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 861360000428 DNA repair protein RadA; Provisional; Region: PRK11823 861360000429 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 861360000430 Walker A motif; other site 861360000431 ATP binding site [chemical binding]; other site 861360000432 Walker B motif; other site 861360000433 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 861360000434 PBP superfamily domain; Region: PBP_like_2; cl17296 861360000435 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 861360000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000437 dimer interface [polypeptide binding]; other site 861360000438 conserved gate region; other site 861360000439 putative PBP binding loops; other site 861360000440 ABC-ATPase subunit interface; other site 861360000441 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 861360000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000443 dimer interface [polypeptide binding]; other site 861360000444 conserved gate region; other site 861360000445 putative PBP binding loops; other site 861360000446 ABC-ATPase subunit interface; other site 861360000447 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 861360000448 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 861360000449 Walker A/P-loop; other site 861360000450 ATP binding site [chemical binding]; other site 861360000451 Q-loop/lid; other site 861360000452 ABC transporter signature motif; other site 861360000453 Walker B; other site 861360000454 D-loop; other site 861360000455 H-loop/switch region; other site 861360000456 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360000457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360000458 non-specific DNA binding site [nucleotide binding]; other site 861360000459 salt bridge; other site 861360000460 sequence-specific DNA binding site [nucleotide binding]; other site 861360000461 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 861360000462 Helix-turn-helix domain; Region: HTH_28; pfam13518 861360000463 Winged helix-turn helix; Region: HTH_29; pfam13551 861360000464 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 861360000465 Integrase core domain; Region: rve; pfam00665 861360000466 Dienelactone hydrolase family; Region: DLH; pfam01738 861360000467 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360000468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360000469 Walker A/P-loop; other site 861360000470 ATP binding site [chemical binding]; other site 861360000471 Q-loop/lid; other site 861360000472 ABC transporter signature motif; other site 861360000473 Walker B; other site 861360000474 D-loop; other site 861360000475 H-loop/switch region; other site 861360000476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360000477 CAAX protease self-immunity; Region: Abi; pfam02517 861360000478 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 861360000479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360000480 S-adenosylmethionine binding site [chemical binding]; other site 861360000481 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 861360000482 putative hydrophobic ligand binding site [chemical binding]; other site 861360000483 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 861360000484 hydrophobic ligand binding site; other site 861360000485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360000486 dimerization interface [polypeptide binding]; other site 861360000487 putative DNA binding site [nucleotide binding]; other site 861360000488 putative Zn2+ binding site [ion binding]; other site 861360000489 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 861360000490 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 861360000491 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 861360000492 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360000493 NAD(P) binding site [chemical binding]; other site 861360000494 catalytic residues [active] 861360000495 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 861360000496 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 861360000497 NAD binding site [chemical binding]; other site 861360000498 substrate binding site [chemical binding]; other site 861360000499 catalytic Zn binding site [ion binding]; other site 861360000500 tetramer interface [polypeptide binding]; other site 861360000501 structural Zn binding site [ion binding]; other site 861360000502 Protein of unknown function (DUF779); Region: DUF779; pfam05610 861360000503 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 861360000504 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 861360000505 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 861360000506 putative homotetramer interface [polypeptide binding]; other site 861360000507 putative homodimer interface [polypeptide binding]; other site 861360000508 putative allosteric switch controlling residues; other site 861360000509 putative metal binding site [ion binding]; other site 861360000510 putative homodimer-homodimer interface [polypeptide binding]; other site 861360000511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 861360000512 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 861360000513 catalytic residues [active] 861360000514 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 861360000515 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 861360000516 active site residue [active] 861360000517 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 861360000518 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 861360000519 active site residue [active] 861360000520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360000521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360000522 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 861360000523 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360000524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360000525 DNA-binding site [nucleotide binding]; DNA binding site 861360000526 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 861360000527 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 861360000528 FAD binding domain; Region: FAD_binding_4; pfam01565 861360000529 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 861360000530 Cysteine-rich domain; Region: CCG; pfam02754 861360000531 amino acid transporter; Region: 2A0306; TIGR00909 861360000532 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 861360000533 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 861360000534 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 861360000535 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 861360000536 dimer interface [polypeptide binding]; other site 861360000537 PYR/PP interface [polypeptide binding]; other site 861360000538 TPP binding site [chemical binding]; other site 861360000539 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360000540 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 861360000541 TPP-binding site [chemical binding]; other site 861360000542 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 861360000543 FAD binding domain; Region: FAD_binding_4; pfam01565 861360000544 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 861360000545 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 861360000546 dimer interface [polypeptide binding]; other site 861360000547 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 861360000548 active site 861360000549 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360000550 substrate binding site [chemical binding]; other site 861360000551 catalytic residue [active] 861360000552 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 861360000553 RibD C-terminal domain; Region: RibD_C; cl17279 861360000554 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 861360000555 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 861360000556 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 861360000557 polyol permease family; Region: 2A0118; TIGR00897 861360000558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360000559 putative substrate translocation pore; other site 861360000560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 861360000561 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 861360000562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 861360000563 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 861360000564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360000565 nucleotide binding site [chemical binding]; other site 861360000566 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 861360000567 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 861360000568 active site 861360000569 catalytic site [active] 861360000570 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 861360000571 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 861360000572 AzlC protein; Region: AzlC; pfam03591 861360000573 Domain of unknown function DUF77; Region: DUF77; pfam01910 861360000574 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 861360000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360000576 S-adenosylmethionine binding site [chemical binding]; other site 861360000577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360000578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360000579 Coenzyme A binding pocket [chemical binding]; other site 861360000580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360000581 S-adenosylmethionine binding site [chemical binding]; other site 861360000582 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 861360000583 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 861360000584 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 861360000585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 861360000586 Ligand Binding Site [chemical binding]; other site 861360000587 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 861360000588 NlpC/P60 family; Region: NLPC_P60; pfam00877 861360000589 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 861360000590 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 861360000591 putative catalytic site [active] 861360000592 putative phosphate binding site [ion binding]; other site 861360000593 active site 861360000594 metal binding site A [ion binding]; metal-binding site 861360000595 DNA binding site [nucleotide binding] 861360000596 putative AP binding site [nucleotide binding]; other site 861360000597 putative metal binding site B [ion binding]; other site 861360000598 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 861360000599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360000600 substrate binding site [chemical binding]; other site 861360000601 oxyanion hole (OAH) forming residues; other site 861360000602 trimer interface [polypeptide binding]; other site 861360000603 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 861360000604 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 861360000605 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 861360000606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360000607 MarR family; Region: MarR_2; pfam12802 861360000608 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360000609 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 861360000610 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 861360000611 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 861360000612 homodimer interface [polypeptide binding]; other site 861360000613 NAD binding pocket [chemical binding]; other site 861360000614 ATP binding pocket [chemical binding]; other site 861360000615 Mg binding site [ion binding]; other site 861360000616 active-site loop [active] 861360000617 MarR family; Region: MarR_2; cl17246 861360000618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360000619 active site 861360000620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360000621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360000622 DNA binding site [nucleotide binding] 861360000623 domain linker motif; other site 861360000624 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 861360000625 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 861360000626 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 861360000627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000628 dimer interface [polypeptide binding]; other site 861360000629 conserved gate region; other site 861360000630 putative PBP binding loops; other site 861360000631 ABC-ATPase subunit interface; other site 861360000632 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 861360000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000634 dimer interface [polypeptide binding]; other site 861360000635 conserved gate region; other site 861360000636 putative PBP binding loops; other site 861360000637 ABC-ATPase subunit interface; other site 861360000638 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 861360000639 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 861360000640 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 861360000641 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 861360000642 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 861360000643 Walker A/P-loop; other site 861360000644 ATP binding site [chemical binding]; other site 861360000645 Q-loop/lid; other site 861360000646 ABC transporter signature motif; other site 861360000647 Walker B; other site 861360000648 D-loop; other site 861360000649 H-loop/switch region; other site 861360000650 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 861360000651 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 861360000652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360000653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360000654 UMP phosphatase; Provisional; Region: PRK10444 861360000655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000656 active site 861360000657 motif I; other site 861360000658 motif II; other site 861360000659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360000660 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 861360000661 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 861360000662 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360000663 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360000664 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 861360000665 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 861360000666 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 861360000667 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 861360000668 active site 861360000669 intersubunit interface [polypeptide binding]; other site 861360000670 zinc binding site [ion binding]; other site 861360000671 Na+ binding site [ion binding]; other site 861360000672 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 861360000673 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 861360000674 putative metal binding residues [ion binding]; other site 861360000675 signature motif; other site 861360000676 dimer interface [polypeptide binding]; other site 861360000677 active site 861360000678 polyP binding site; other site 861360000679 substrate binding site [chemical binding]; other site 861360000680 acceptor-phosphate pocket; other site 861360000681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360000682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360000683 active site 861360000684 phosphorylation site [posttranslational modification] 861360000685 intermolecular recognition site; other site 861360000686 dimerization interface [polypeptide binding]; other site 861360000687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360000688 DNA binding site [nucleotide binding] 861360000689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360000690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 861360000691 dimerization interface [polypeptide binding]; other site 861360000692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360000693 dimer interface [polypeptide binding]; other site 861360000694 phosphorylation site [posttranslational modification] 861360000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360000696 ATP binding site [chemical binding]; other site 861360000697 Mg2+ binding site [ion binding]; other site 861360000698 G-X-G motif; other site 861360000699 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360000700 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 861360000701 putative DNA binding site [nucleotide binding]; other site 861360000702 putative Zn2+ binding site [ion binding]; other site 861360000703 AsnC family; Region: AsnC_trans_reg; pfam01037 861360000704 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 861360000705 kynureninase; Region: kynureninase; TIGR01814 861360000706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360000707 catalytic residue [active] 861360000708 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 861360000709 thymidine kinase; Provisional; Region: PRK04296 861360000710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360000711 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 861360000712 FAD binding domain; Region: FAD_binding_4; pfam01565 861360000713 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 861360000714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360000715 D-xylulose kinase; Region: XylB; TIGR01312 861360000716 nucleotide binding site [chemical binding]; other site 861360000717 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 861360000718 xylose isomerase; Provisional; Region: PRK12677 861360000719 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360000720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 861360000721 nucleotide binding site [chemical binding]; other site 861360000722 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 861360000723 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 861360000724 DNA binding residues [nucleotide binding] 861360000725 drug binding residues [chemical binding]; other site 861360000726 dimer interface [polypeptide binding]; other site 861360000727 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 861360000728 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 861360000729 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 861360000730 GDP-binding site [chemical binding]; other site 861360000731 ACT binding site; other site 861360000732 IMP binding site; other site 861360000733 thiamine pyrophosphate protein; Validated; Region: PRK08199 861360000734 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 861360000735 PYR/PP interface [polypeptide binding]; other site 861360000736 dimer interface [polypeptide binding]; other site 861360000737 TPP binding site [chemical binding]; other site 861360000738 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360000739 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 861360000740 TPP-binding site [chemical binding]; other site 861360000741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360000742 Integrase core domain; Region: rve; pfam00665 861360000743 Integrase core domain; Region: rve_3; pfam13683 861360000744 Transposase; Region: HTH_Tnp_1; pfam01527 861360000745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360000746 putative transposase OrfB; Reviewed; Region: PHA02517 861360000747 HTH-like domain; Region: HTH_21; pfam13276 861360000748 Integrase core domain; Region: rve; pfam00665 861360000749 Integrase core domain; Region: rve_3; pfam13683 861360000750 Src Homology 3 domain superfamily; Region: SH3; cl17036 861360000751 peptide ligand binding site [polypeptide binding]; other site 861360000752 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 861360000753 hydrophobic ligand binding site; other site 861360000754 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360000755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360000756 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360000757 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 861360000758 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 861360000759 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 861360000760 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 861360000761 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 861360000762 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 861360000763 putative substrate binding site [chemical binding]; other site 861360000764 putative ATP binding site [chemical binding]; other site 861360000765 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 861360000766 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 861360000767 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 861360000768 CAAX protease self-immunity; Region: Abi; pfam02517 861360000769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360000770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360000771 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360000772 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 861360000773 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 861360000774 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 861360000775 homodimer interface [polypeptide binding]; other site 861360000776 substrate-cofactor binding pocket; other site 861360000777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360000778 catalytic residue [active] 861360000779 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360000780 catalytic core [active] 861360000781 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 861360000782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360000783 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 861360000784 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 861360000785 DNA binding site [nucleotide binding] 861360000786 active site 861360000787 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 861360000788 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 861360000789 dimer interface [polypeptide binding]; other site 861360000790 active site 861360000791 heme binding site [chemical binding]; other site 861360000792 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 861360000793 heme binding site [chemical binding]; other site 861360000794 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 861360000795 metal binding site 2 [ion binding]; metal-binding site 861360000796 putative DNA binding helix; other site 861360000797 metal binding site 1 [ion binding]; metal-binding site 861360000798 dimer interface [polypeptide binding]; other site 861360000799 structural Zn2+ binding site [ion binding]; other site 861360000800 BCCT family transporter; Region: BCCT; pfam02028 861360000801 acetyl-CoA synthetase; Provisional; Region: PRK00174 861360000802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360000803 acyl-activating enzyme (AAE) consensus motif; other site 861360000804 AMP binding site [chemical binding]; other site 861360000805 active site 861360000806 CoA binding site [chemical binding]; other site 861360000807 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 861360000808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000809 dimer interface [polypeptide binding]; other site 861360000810 conserved gate region; other site 861360000811 putative PBP binding loops; other site 861360000812 ABC-ATPase subunit interface; other site 861360000813 NMT1/THI5 like; Region: NMT1; pfam09084 861360000814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360000815 substrate binding pocket [chemical binding]; other site 861360000816 membrane-bound complex binding site; other site 861360000817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 861360000818 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 861360000819 Walker A/P-loop; other site 861360000820 ATP binding site [chemical binding]; other site 861360000821 Q-loop/lid; other site 861360000822 ABC transporter signature motif; other site 861360000823 Walker B; other site 861360000824 D-loop; other site 861360000825 H-loop/switch region; other site 861360000826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360000827 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 861360000828 active site 861360000829 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 861360000830 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 861360000831 non-prolyl cis peptide bond; other site 861360000832 active site 861360000833 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 861360000834 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 861360000835 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 861360000836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360000837 NAD(P) binding site [chemical binding]; other site 861360000838 active site 861360000839 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 861360000840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360000841 Walker A/P-loop; other site 861360000842 ATP binding site [chemical binding]; other site 861360000843 Q-loop/lid; other site 861360000844 ABC transporter signature motif; other site 861360000845 Walker B; other site 861360000846 D-loop; other site 861360000847 H-loop/switch region; other site 861360000848 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 861360000849 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 861360000850 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 861360000851 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 861360000852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000854 dimer interface [polypeptide binding]; other site 861360000855 conserved gate region; other site 861360000856 putative PBP binding loops; other site 861360000857 ABC-ATPase subunit interface; other site 861360000858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 861360000859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360000860 dimer interface [polypeptide binding]; other site 861360000861 conserved gate region; other site 861360000862 ABC-ATPase subunit interface; other site 861360000863 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360000864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360000865 Walker A/P-loop; other site 861360000866 ATP binding site [chemical binding]; other site 861360000867 Q-loop/lid; other site 861360000868 ABC transporter signature motif; other site 861360000869 Walker B; other site 861360000870 D-loop; other site 861360000871 H-loop/switch region; other site 861360000872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360000873 Walker A/P-loop; other site 861360000874 ATP binding site [chemical binding]; other site 861360000875 Q-loop/lid; other site 861360000876 ABC transporter signature motif; other site 861360000877 Walker B; other site 861360000878 D-loop; other site 861360000879 H-loop/switch region; other site 861360000880 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360000881 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 861360000882 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 861360000883 Flavin binding site [chemical binding]; other site 861360000884 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 861360000885 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 861360000886 active site 861360000887 non-prolyl cis peptide bond; other site 861360000888 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 861360000889 metal ion-dependent adhesion site (MIDAS); other site 861360000890 Cna protein B-type domain; Region: Cna_B; pfam05738 861360000891 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 861360000892 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 861360000893 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 861360000894 active site 861360000895 catalytic site [active] 861360000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 861360000897 Uncharacterized conserved protein [Function unknown]; Region: COG1359 861360000898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360000899 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 861360000900 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 861360000901 putative active site [active] 861360000902 putative metal binding site [ion binding]; other site 861360000903 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 861360000904 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 861360000905 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 861360000906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360000907 NAD(P) binding site [chemical binding]; other site 861360000908 active site 861360000909 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 861360000910 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 861360000911 active site 861360000912 non-prolyl cis peptide bond; other site 861360000913 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 861360000914 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 861360000915 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 861360000916 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360000917 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360000918 FAD binding pocket [chemical binding]; other site 861360000919 FAD binding motif [chemical binding]; other site 861360000920 phosphate binding motif [ion binding]; other site 861360000921 NAD binding pocket [chemical binding]; other site 861360000922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360000923 ABC-ATPase subunit interface; other site 861360000924 dimer interface [polypeptide binding]; other site 861360000925 putative PBP binding regions; other site 861360000926 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360000927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360000928 ABC-ATPase subunit interface; other site 861360000929 dimer interface [polypeptide binding]; other site 861360000930 putative PBP binding regions; other site 861360000931 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 861360000932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360000933 intersubunit interface [polypeptide binding]; other site 861360000934 Cupin domain; Region: Cupin_2; cl17218 861360000935 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 861360000936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360000937 Helix-turn-helix domain; Region: HTH_18; pfam12833 861360000938 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360000939 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360000940 FAD binding pocket [chemical binding]; other site 861360000941 FAD binding motif [chemical binding]; other site 861360000942 phosphate binding motif [ion binding]; other site 861360000943 NAD binding pocket [chemical binding]; other site 861360000944 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 861360000945 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 861360000946 PhnA protein; Region: PhnA; pfam03831 861360000947 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 861360000948 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 861360000949 dimerization interface [polypeptide binding]; other site 861360000950 ATP binding site [chemical binding]; other site 861360000951 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 861360000952 dimerization interface [polypeptide binding]; other site 861360000953 ATP binding site [chemical binding]; other site 861360000954 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 861360000955 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 861360000956 putative active site [active] 861360000957 catalytic triad [active] 861360000958 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 861360000959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 861360000960 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 861360000961 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 861360000962 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 861360000963 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 861360000964 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 861360000965 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 861360000966 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 861360000967 Protein of unknown function (DUF664); Region: DUF664; pfam04978 861360000968 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 861360000969 hydrophobic ligand binding site; other site 861360000970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360000971 TIGR01777 family protein; Region: yfcH 861360000972 NAD(P) binding site [chemical binding]; other site 861360000973 active site 861360000974 ferrochelatase; Reviewed; Region: hemH; PRK00035 861360000975 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 861360000976 C-terminal domain interface [polypeptide binding]; other site 861360000977 active site 861360000978 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 861360000979 active site 861360000980 N-terminal domain interface [polypeptide binding]; other site 861360000981 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 861360000982 Citrate transporter; Region: CitMHS; pfam03600 861360000983 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 861360000984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360000985 active site 861360000986 phosphorylation site [posttranslational modification] 861360000987 intermolecular recognition site; other site 861360000988 dimerization interface [polypeptide binding]; other site 861360000989 Phosphotransferase enzyme family; Region: APH; pfam01636 861360000990 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 861360000991 active site 861360000992 ATP binding site [chemical binding]; other site 861360000993 substrate binding site [chemical binding]; other site 861360000994 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 861360000995 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 861360000996 putative active site [active] 861360000997 putative metal binding site [ion binding]; other site 861360000998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360000999 aspartate kinase; Reviewed; Region: PRK06635 861360001000 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 861360001001 putative nucleotide binding site [chemical binding]; other site 861360001002 putative catalytic residues [active] 861360001003 putative Mg ion binding site [ion binding]; other site 861360001004 putative aspartate binding site [chemical binding]; other site 861360001005 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 861360001006 putative allosteric regulatory site; other site 861360001007 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 861360001008 putative allosteric regulatory residue; other site 861360001009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360001010 MarR family; Region: MarR_2; pfam12802 861360001011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360001013 putative substrate translocation pore; other site 861360001014 recombination protein RecR; Reviewed; Region: recR; PRK00076 861360001015 RecR protein; Region: RecR; pfam02132 861360001016 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 861360001017 putative active site [active] 861360001018 putative metal-binding site [ion binding]; other site 861360001019 tetramer interface [polypeptide binding]; other site 861360001020 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 861360001021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360001022 Walker A motif; other site 861360001023 ATP binding site [chemical binding]; other site 861360001024 Walker B motif; other site 861360001025 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 861360001026 arginine finger; other site 861360001027 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 861360001028 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 861360001029 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 861360001030 active site 861360001031 HIGH motif; other site 861360001032 nucleotide binding site [chemical binding]; other site 861360001033 active site 861360001034 KMSKS motif; other site 861360001035 Domain of unknown function (DUF222); Region: DUF222; pfam02720 861360001036 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360001037 active site 861360001038 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 861360001039 active site 861360001040 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 861360001041 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 861360001042 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 861360001043 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 861360001044 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 861360001045 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 861360001046 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 861360001047 catalytic residues [active] 861360001048 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 861360001049 putative proline-specific permease; Provisional; Region: proY; PRK10580 861360001050 Spore germination protein; Region: Spore_permease; cl17796 861360001051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360001052 catalytic core [active] 861360001053 monoglyceride lipase; Provisional; Region: PHA02857 861360001054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 861360001055 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 861360001056 malate synthase A; Region: malate_syn_A; TIGR01344 861360001057 active site 861360001058 isocitrate lyase; Provisional; Region: PRK15063 861360001059 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 861360001060 tetramer interface [polypeptide binding]; other site 861360001061 active site 861360001062 Mg2+/Mn2+ binding site [ion binding]; other site 861360001063 HutD; Region: HutD; cl01532 861360001064 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 861360001065 thymidylate kinase; Validated; Region: tmk; PRK00698 861360001066 active site 861360001067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360001068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360001069 non-specific DNA binding site [nucleotide binding]; other site 861360001070 salt bridge; other site 861360001071 sequence-specific DNA binding site [nucleotide binding]; other site 861360001072 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 861360001073 Domain of unknown function (DUF955); Region: DUF955; pfam06114 861360001074 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 861360001075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360001076 Coenzyme A binding pocket [chemical binding]; other site 861360001077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360001078 active site 861360001079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360001080 Coenzyme A binding pocket [chemical binding]; other site 861360001081 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 861360001082 Clp amino terminal domain; Region: Clp_N; pfam02861 861360001083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360001084 Walker A motif; other site 861360001085 ATP binding site [chemical binding]; other site 861360001086 Walker B motif; other site 861360001087 arginine finger; other site 861360001088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360001089 Walker A motif; other site 861360001090 ATP binding site [chemical binding]; other site 861360001091 Walker B motif; other site 861360001092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 861360001093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360001094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360001095 active site 861360001096 phosphorylation site [posttranslational modification] 861360001097 intermolecular recognition site; other site 861360001098 dimerization interface [polypeptide binding]; other site 861360001099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360001100 DNA binding residues [nucleotide binding] 861360001101 dimerization interface [polypeptide binding]; other site 861360001102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360001103 Histidine kinase; Region: HisKA_3; pfam07730 861360001104 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 861360001105 putative FMN binding site [chemical binding]; other site 861360001106 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 861360001107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360001108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360001109 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360001110 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 861360001111 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 861360001112 putative NAD(P) binding site [chemical binding]; other site 861360001113 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 861360001114 Catalytic site [active] 861360001115 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 861360001116 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 861360001117 active site 861360001118 DNA binding site [nucleotide binding] 861360001119 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 861360001120 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 861360001121 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 861360001122 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 861360001123 putative active site [active] 861360001124 catalytic triad [active] 861360001125 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 861360001126 catalytic residues [active] 861360001127 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 861360001128 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 861360001129 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360001130 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360001131 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 861360001132 substrate binding site [chemical binding]; other site 861360001133 dimer interface [polypeptide binding]; other site 861360001134 ATP binding site [chemical binding]; other site 861360001135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360001136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360001137 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 861360001138 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 861360001139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001140 Walker A/P-loop; other site 861360001141 ATP binding site [chemical binding]; other site 861360001142 ABC transporter signature motif; other site 861360001143 Walker B; other site 861360001144 D-loop; other site 861360001145 H-loop/switch region; other site 861360001146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360001147 Coenzyme A binding pocket [chemical binding]; other site 861360001148 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 861360001149 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 861360001150 Predicted membrane protein [Function unknown]; Region: COG1289 861360001151 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 861360001152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001153 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 861360001154 putative substrate translocation pore; other site 861360001155 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 861360001156 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 861360001157 NAD binding site [chemical binding]; other site 861360001158 homodimer interface [polypeptide binding]; other site 861360001159 homotetramer interface [polypeptide binding]; other site 861360001160 active site 861360001161 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360001162 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 861360001163 catalytic residues [active] 861360001164 catalytic nucleophile [active] 861360001165 Recombinase; Region: Recombinase; pfam07508 861360001166 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 861360001167 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 861360001168 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 861360001169 dimer interface [polypeptide binding]; other site 861360001170 ssDNA binding site [nucleotide binding]; other site 861360001171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 861360001172 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 861360001173 Walker A motif; other site 861360001174 ATP binding site [chemical binding]; other site 861360001175 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 861360001176 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 861360001177 AAA-like domain; Region: AAA_10; pfam12846 861360001178 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360001179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001180 Walker A/P-loop; other site 861360001181 ATP binding site [chemical binding]; other site 861360001182 Q-loop/lid; other site 861360001183 ABC transporter signature motif; other site 861360001184 Walker B; other site 861360001185 D-loop; other site 861360001186 H-loop/switch region; other site 861360001187 ABC transporter; Region: ABC_tran_2; pfam12848 861360001188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360001189 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 861360001190 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 861360001191 NADP binding site [chemical binding]; other site 861360001192 dimer interface [polypeptide binding]; other site 861360001193 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 861360001194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360001195 S-adenosylmethionine binding site [chemical binding]; other site 861360001196 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360001197 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360001198 ParB-like nuclease domain; Region: ParB; smart00470 861360001199 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 861360001200 Helix-turn-helix domain; Region: HTH_38; pfam13936 861360001201 DNA-binding interface [nucleotide binding]; DNA binding site 861360001202 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 861360001203 polymerase nucleotide-binding site; other site 861360001204 DNA-binding residues [nucleotide binding]; DNA binding site 861360001205 nucleotide binding site [chemical binding]; other site 861360001206 primase nucleotide-binding site [nucleotide binding]; other site 861360001207 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 861360001208 Domain of unknown function (DUF955); Region: DUF955; pfam06114 861360001209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360001210 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 861360001211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360001214 putative substrate translocation pore; other site 861360001215 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360001216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001217 Walker A/P-loop; other site 861360001218 ATP binding site [chemical binding]; other site 861360001219 Q-loop/lid; other site 861360001220 ABC transporter signature motif; other site 861360001221 Walker B; other site 861360001222 D-loop; other site 861360001223 H-loop/switch region; other site 861360001224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360001225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001226 Walker A/P-loop; other site 861360001227 ATP binding site [chemical binding]; other site 861360001228 Q-loop/lid; other site 861360001229 ABC transporter signature motif; other site 861360001230 Walker B; other site 861360001231 D-loop; other site 861360001232 H-loop/switch region; other site 861360001233 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 861360001234 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 861360001235 Walker A/P-loop; other site 861360001236 ATP binding site [chemical binding]; other site 861360001237 Q-loop/lid; other site 861360001238 ABC transporter signature motif; other site 861360001239 Walker B; other site 861360001240 D-loop; other site 861360001241 H-loop/switch region; other site 861360001242 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 861360001243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360001244 ABC-ATPase subunit interface; other site 861360001245 dimer interface [polypeptide binding]; other site 861360001246 putative PBP binding regions; other site 861360001247 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360001248 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360001249 ABC-ATPase subunit interface; other site 861360001250 dimer interface [polypeptide binding]; other site 861360001251 putative PBP binding regions; other site 861360001252 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 861360001253 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360001254 intersubunit interface [polypeptide binding]; other site 861360001255 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 861360001256 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360001257 intersubunit interface [polypeptide binding]; other site 861360001258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360001259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001260 putative substrate translocation pore; other site 861360001261 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360001262 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360001263 FAD binding pocket [chemical binding]; other site 861360001264 FAD binding motif [chemical binding]; other site 861360001265 phosphate binding motif [ion binding]; other site 861360001266 NAD binding pocket [chemical binding]; other site 861360001267 Helix-turn-helix domain; Region: HTH_18; pfam12833 861360001268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360001269 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 861360001270 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 861360001271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360001272 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 861360001273 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 861360001274 cofactor binding site; other site 861360001275 DNA binding site [nucleotide binding] 861360001276 substrate interaction site [chemical binding]; other site 861360001277 TrwC relaxase; Region: TrwC; pfam08751 861360001278 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 861360001279 AAA domain; Region: AAA_30; pfam13604 861360001280 AAA domain; Region: AAA_22; pfam13401 861360001281 DNA protecting protein DprA; Region: dprA; TIGR00732 861360001282 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 861360001283 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 861360001284 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 861360001285 active site 861360001286 DNA binding site [nucleotide binding] 861360001287 Int/Topo IB signature motif; other site 861360001288 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 861360001289 active site 861360001290 catalytic residues [active] 861360001291 DNA binding site [nucleotide binding] 861360001292 Int/Topo IB signature motif; other site 861360001293 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 861360001294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001295 Walker A/P-loop; other site 861360001296 ATP binding site [chemical binding]; other site 861360001297 Q-loop/lid; other site 861360001298 ABC transporter signature motif; other site 861360001299 Walker B; other site 861360001300 D-loop; other site 861360001301 H-loop/switch region; other site 861360001302 Histidine kinase; Region: HisKA_3; pfam07730 861360001303 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 861360001304 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360001305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360001306 active site 861360001307 phosphorylation site [posttranslational modification] 861360001308 intermolecular recognition site; other site 861360001309 dimerization interface [polypeptide binding]; other site 861360001310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360001311 DNA binding residues [nucleotide binding] 861360001312 dimerization interface [polypeptide binding]; other site 861360001313 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 861360001314 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 861360001315 active site 861360001316 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 861360001317 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 861360001318 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 861360001319 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 861360001320 putative DNA binding site [nucleotide binding]; other site 861360001321 catalytic residue [active] 861360001322 putative H2TH interface [polypeptide binding]; other site 861360001323 putative catalytic residues [active] 861360001324 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 861360001325 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 861360001326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360001327 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 861360001328 ATP binding site [chemical binding]; other site 861360001329 putative Mg++ binding site [ion binding]; other site 861360001330 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360001331 nucleotide binding region [chemical binding]; other site 861360001332 ATP-binding site [chemical binding]; other site 861360001333 DEAD/H associated; Region: DEAD_assoc; pfam08494 861360001334 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 861360001335 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 861360001336 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 861360001337 active site 861360001338 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 861360001339 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 861360001340 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 861360001341 dimerization interface [polypeptide binding]; other site 861360001342 NAD binding site [chemical binding]; other site 861360001343 ligand binding site [chemical binding]; other site 861360001344 catalytic site [active] 861360001345 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360001346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 861360001347 active site 861360001348 metal binding site [ion binding]; metal-binding site 861360001349 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 861360001350 active site 861360001351 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 861360001352 benzoate transporter; Region: benE; TIGR00843 861360001353 L-aspartate dehydrogenase; Provisional; Region: PRK13303 861360001354 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 861360001355 Domain of unknown function DUF108; Region: DUF108; pfam01958 861360001356 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 861360001357 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 861360001358 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 861360001359 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 861360001360 tetramer interface [polypeptide binding]; other site 861360001361 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 861360001362 heterodimer interface [polypeptide binding]; other site 861360001363 active site 861360001364 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 861360001365 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 861360001366 active site 861360001367 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 861360001368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360001369 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 861360001370 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360001371 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360001372 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360001373 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 861360001374 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360001375 dimer interface [polypeptide binding]; other site 861360001376 active site 861360001377 Coenzyme A transferase; Region: CoA_trans; cl17247 861360001378 Coenzyme A transferase; Region: CoA_trans; cl17247 861360001379 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 861360001380 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360001381 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360001382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360001383 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360001384 active site 861360001385 Lipase (class 2); Region: Lipase_2; pfam01674 861360001386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360001387 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 861360001388 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360001389 MarR family; Region: MarR_2; pfam12802 861360001390 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 861360001391 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 861360001392 MPT binding site; other site 861360001393 trimer interface [polypeptide binding]; other site 861360001394 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 861360001395 trimer interface [polypeptide binding]; other site 861360001396 dimer interface [polypeptide binding]; other site 861360001397 putative active site [active] 861360001398 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 861360001399 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 861360001400 dimer interface [polypeptide binding]; other site 861360001401 putative functional site; other site 861360001402 putative MPT binding site; other site 861360001403 Ubiquitin-like proteins; Region: UBQ; cl00155 861360001404 charged pocket; other site 861360001405 hydrophobic patch; other site 861360001406 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 861360001407 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 861360001408 ATP binding site [chemical binding]; other site 861360001409 substrate interface [chemical binding]; other site 861360001410 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 861360001411 active site residue [active] 861360001412 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 861360001413 MoaE homodimer interface [polypeptide binding]; other site 861360001414 MoaD interaction [polypeptide binding]; other site 861360001415 active site residues [active] 861360001416 HTH domain; Region: HTH_11; pfam08279 861360001417 Predicted transcriptional regulator [Transcription]; Region: COG2378 861360001418 WYL domain; Region: WYL; pfam13280 861360001419 Protein of unknown function (DUF664); Region: DUF664; pfam04978 861360001420 DinB superfamily; Region: DinB_2; pfam12867 861360001421 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 861360001422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360001423 FeS/SAM binding site; other site 861360001424 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 861360001425 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 861360001426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 861360001427 dimerization interface [polypeptide binding]; other site 861360001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360001429 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 861360001430 dimer interface [polypeptide binding]; other site 861360001431 conserved gate region; other site 861360001432 putative PBP binding loops; other site 861360001433 ABC-ATPase subunit interface; other site 861360001434 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 861360001435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360001436 Walker A/P-loop; other site 861360001437 ATP binding site [chemical binding]; other site 861360001438 Q-loop/lid; other site 861360001439 ABC transporter signature motif; other site 861360001440 Walker B; other site 861360001441 D-loop; other site 861360001442 H-loop/switch region; other site 861360001443 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 861360001444 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 861360001445 dimer interface [polypeptide binding]; other site 861360001446 putative functional site; other site 861360001447 putative MPT binding site; other site 861360001448 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 861360001449 GTP binding site; other site 861360001450 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 861360001451 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 861360001452 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 861360001453 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 861360001454 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 861360001455 gating phenylalanine in ion channel; other site 861360001456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360001457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360001458 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 861360001459 putative dimerization interface [polypeptide binding]; other site 861360001460 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 861360001461 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 861360001462 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 861360001463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360001464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001465 putative substrate translocation pore; other site 861360001466 YaeQ protein; Region: YaeQ; pfam07152 861360001467 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 861360001468 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 861360001469 active site 861360001470 catalytic site [active] 861360001471 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 861360001472 nucleoside/Zn binding site; other site 861360001473 dimer interface [polypeptide binding]; other site 861360001474 catalytic motif [active] 861360001475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360001476 active site 861360001477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360001478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360001479 dimer interface [polypeptide binding]; other site 861360001480 phosphorylation site [posttranslational modification] 861360001481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360001482 ATP binding site [chemical binding]; other site 861360001483 Mg2+ binding site [ion binding]; other site 861360001484 G-X-G motif; other site 861360001485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360001486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360001487 active site 861360001488 phosphorylation site [posttranslational modification] 861360001489 intermolecular recognition site; other site 861360001490 dimerization interface [polypeptide binding]; other site 861360001491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360001492 DNA binding site [nucleotide binding] 861360001493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360001494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360001495 DNA binding site [nucleotide binding] 861360001496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360001497 catalytic core [active] 861360001498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360001499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360001500 Predicted membrane protein [Function unknown]; Region: COG1511 861360001501 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 861360001502 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 861360001503 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 861360001504 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 861360001505 generic binding surface II; other site 861360001506 generic binding surface I; other site 861360001507 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 861360001508 putative active site [active] 861360001509 putative catalytic site [active] 861360001510 putative Mg binding site IVb [ion binding]; other site 861360001511 putative DNA binding site [nucleotide binding]; other site 861360001512 putative phosphate binding site [ion binding]; other site 861360001513 putative Mg binding site IVa [ion binding]; other site 861360001514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360001515 dimer interface [polypeptide binding]; other site 861360001516 conserved gate region; other site 861360001517 putative PBP binding loops; other site 861360001518 ABC-ATPase subunit interface; other site 861360001519 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 861360001520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360001521 dimer interface [polypeptide binding]; other site 861360001522 conserved gate region; other site 861360001523 putative PBP binding loops; other site 861360001524 ABC-ATPase subunit interface; other site 861360001525 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 861360001526 beta-galactosidase; Region: BGL; TIGR03356 861360001527 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360001528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360001529 DNA binding site [nucleotide binding] 861360001530 domain linker motif; other site 861360001531 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 861360001532 putative dimerization interface [polypeptide binding]; other site 861360001533 putative ligand binding site [chemical binding]; other site 861360001534 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 861360001535 active site 861360001536 substrate-binding site [chemical binding]; other site 861360001537 metal-binding site [ion binding] 861360001538 GTP binding site [chemical binding]; other site 861360001539 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360001540 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360001541 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 861360001542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360001543 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 861360001544 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 861360001545 heme-binding site [chemical binding]; other site 861360001546 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 861360001547 FAD binding pocket [chemical binding]; other site 861360001548 FAD binding motif [chemical binding]; other site 861360001549 phosphate binding motif [ion binding]; other site 861360001550 beta-alpha-beta structure motif; other site 861360001551 NAD binding pocket [chemical binding]; other site 861360001552 Heme binding pocket [chemical binding]; other site 861360001553 Transcriptional regulator; Region: Rrf2; cl17282 861360001554 Rrf2 family protein; Region: rrf2_super; TIGR00738 861360001555 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 861360001556 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 861360001557 active site 861360001558 substrate binding site [chemical binding]; other site 861360001559 metal binding site [ion binding]; metal-binding site 861360001560 DEAD-like helicases superfamily; Region: DEXDc; smart00487 861360001561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360001562 ATP binding site [chemical binding]; other site 861360001563 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 861360001564 putative Mg++ binding site [ion binding]; other site 861360001565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360001566 nucleotide binding region [chemical binding]; other site 861360001567 ATP-binding site [chemical binding]; other site 861360001568 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 861360001569 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360001570 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 861360001571 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 861360001572 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 861360001573 NAD(P) binding site [chemical binding]; other site 861360001574 Protein of unknown function (DUF466); Region: DUF466; pfam04328 861360001575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360001576 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360001577 active site 861360001578 catalytic tetrad [active] 861360001579 TAP-like protein; Region: Abhydrolase_4; pfam08386 861360001580 DNA polymerase III subunit delta'; Validated; Region: PRK07940 861360001581 DNA polymerase III subunit delta'; Validated; Region: PRK08485 861360001582 thymidylate kinase; Validated; Region: tmk; PRK00698 861360001583 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 861360001584 TMP-binding site; other site 861360001585 ATP-binding site [chemical binding]; other site 861360001586 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 861360001587 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 861360001588 homodimer interface [polypeptide binding]; other site 861360001589 substrate-cofactor binding pocket; other site 861360001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360001591 catalytic residue [active] 861360001592 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 861360001593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360001594 catalytic core [active] 861360001595 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 861360001596 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 861360001597 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 861360001598 PhoU domain; Region: PhoU; pfam01895 861360001599 PhoU domain; Region: PhoU; pfam01895 861360001600 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 861360001601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360001602 dimer interface [polypeptide binding]; other site 861360001603 phosphorylation site [posttranslational modification] 861360001604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360001605 ATP binding site [chemical binding]; other site 861360001606 Mg2+ binding site [ion binding]; other site 861360001607 G-X-G motif; other site 861360001608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360001609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360001610 active site 861360001611 phosphorylation site [posttranslational modification] 861360001612 intermolecular recognition site; other site 861360001613 dimerization interface [polypeptide binding]; other site 861360001614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360001615 DNA binding site [nucleotide binding] 861360001616 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 861360001617 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 861360001618 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 861360001619 substrate binding site; other site 861360001620 dimer interface; other site 861360001621 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 861360001622 homotrimer interaction site [polypeptide binding]; other site 861360001623 zinc binding site [ion binding]; other site 861360001624 CDP-binding sites; other site 861360001625 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 861360001626 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360001627 active site 861360001628 HIGH motif; other site 861360001629 nucleotide binding site [chemical binding]; other site 861360001630 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 861360001631 KMSKS motif; other site 861360001632 tRNA binding surface [nucleotide binding]; other site 861360001633 anticodon binding site; other site 861360001634 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 861360001635 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 861360001636 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 861360001637 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 861360001638 FAD binding domain; Region: FAD_binding_4; pfam01565 861360001639 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 861360001640 MULE transposase domain; Region: MULE; pfam10551 861360001641 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 861360001642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360001643 NAD(P) binding site [chemical binding]; other site 861360001644 active site 861360001645 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 861360001646 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 861360001647 Walker A/P-loop; other site 861360001648 ATP binding site [chemical binding]; other site 861360001649 Q-loop/lid; other site 861360001650 ABC transporter signature motif; other site 861360001651 Walker B; other site 861360001652 D-loop; other site 861360001653 H-loop/switch region; other site 861360001654 TOBE domain; Region: TOBE_2; pfam08402 861360001655 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 861360001656 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 861360001657 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 861360001658 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 861360001659 active site 861360001660 homotetramer interface [polypeptide binding]; other site 861360001661 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 861360001662 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 861360001663 catalytic residues [active] 861360001664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 861360001665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360001666 S-adenosylmethionine binding site [chemical binding]; other site 861360001667 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 861360001668 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360001669 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 861360001670 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 861360001671 Uncharacterized conserved protein [Function unknown]; Region: COG2966 861360001672 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 861360001673 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 861360001674 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 861360001675 ligand binding site [chemical binding]; other site 861360001676 active site 861360001677 UGI interface [polypeptide binding]; other site 861360001678 catalytic site [active] 861360001679 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 861360001680 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 861360001681 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 861360001682 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 861360001683 ring oligomerisation interface [polypeptide binding]; other site 861360001684 ATP/Mg binding site [chemical binding]; other site 861360001685 stacking interactions; other site 861360001686 hinge regions; other site 861360001687 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 861360001688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 861360001689 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 861360001690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360001691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 861360001692 dimerization interface [polypeptide binding]; other site 861360001693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360001694 dimer interface [polypeptide binding]; other site 861360001695 phosphorylation site [posttranslational modification] 861360001696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360001697 ATP binding site [chemical binding]; other site 861360001698 Mg2+ binding site [ion binding]; other site 861360001699 G-X-G motif; other site 861360001700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360001701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360001702 active site 861360001703 phosphorylation site [posttranslational modification] 861360001704 intermolecular recognition site; other site 861360001705 dimerization interface [polypeptide binding]; other site 861360001706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360001707 DNA binding site [nucleotide binding] 861360001708 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 861360001709 DNA-binding site [nucleotide binding]; DNA binding site 861360001710 RNA-binding motif; other site 861360001711 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 861360001712 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 861360001713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360001714 catalytic residue [active] 861360001715 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 861360001716 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 861360001717 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 861360001718 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 861360001719 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360001720 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360001721 NlpC/P60 family; Region: NLPC_P60; cl17555 861360001722 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 861360001723 nudix motif; other site 861360001724 putative DNA binding site [nucleotide binding]; other site 861360001725 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 861360001726 putative Zn2+ binding site [ion binding]; other site 861360001727 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360001728 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360001729 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 861360001730 Part of AAA domain; Region: AAA_19; pfam13245 861360001731 Family description; Region: UvrD_C_2; pfam13538 861360001732 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 861360001733 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 861360001734 CoA-ligase; Region: Ligase_CoA; pfam00549 861360001735 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 861360001736 CoA binding domain; Region: CoA_binding; smart00881 861360001737 CoA-ligase; Region: Ligase_CoA; pfam00549 861360001738 proline/glycine betaine transporter; Provisional; Region: PRK10642 861360001739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001740 putative substrate translocation pore; other site 861360001741 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 861360001742 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 861360001743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360001744 ATP binding site [chemical binding]; other site 861360001745 putative Mg++ binding site [ion binding]; other site 861360001746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360001747 nucleotide binding region [chemical binding]; other site 861360001748 ATP-binding site [chemical binding]; other site 861360001749 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 861360001750 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 861360001751 diiron binding motif [ion binding]; other site 861360001752 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 861360001753 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 861360001754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360001755 non-specific DNA binding site [nucleotide binding]; other site 861360001756 salt bridge; other site 861360001757 sequence-specific DNA binding site [nucleotide binding]; other site 861360001758 Cupin domain; Region: Cupin_2; pfam07883 861360001759 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 861360001760 agmatinase; Region: agmatinase; TIGR01230 861360001761 oligomer interface [polypeptide binding]; other site 861360001762 putative active site [active] 861360001763 Mn binding site [ion binding]; other site 861360001764 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 861360001765 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 861360001766 PYR/PP interface [polypeptide binding]; other site 861360001767 dimer interface [polypeptide binding]; other site 861360001768 TPP binding site [chemical binding]; other site 861360001769 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360001770 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 861360001771 TPP-binding site [chemical binding]; other site 861360001772 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 861360001773 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 861360001774 active site 861360001775 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360001776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360001777 putative DNA binding site [nucleotide binding]; other site 861360001778 putative Zn2+ binding site [ion binding]; other site 861360001779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360001781 putative substrate translocation pore; other site 861360001782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001783 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360001784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360001785 DNA-binding site [nucleotide binding]; DNA binding site 861360001786 FCD domain; Region: FCD; pfam07729 861360001787 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 861360001788 CoA-transferase family III; Region: CoA_transf_3; pfam02515 861360001789 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360001790 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360001791 active site 861360001792 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 861360001793 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360001794 NAD(P) binding site [chemical binding]; other site 861360001795 catalytic residues [active] 861360001796 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 861360001797 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 861360001798 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 861360001799 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 861360001800 Uncharacterized conserved protein [Function unknown]; Region: COG4850 861360001801 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 861360001802 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 861360001803 active site 861360001804 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360001805 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360001806 FAD binding pocket [chemical binding]; other site 861360001807 FAD binding motif [chemical binding]; other site 861360001808 phosphate binding motif [ion binding]; other site 861360001809 NAD binding pocket [chemical binding]; other site 861360001810 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 861360001811 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 861360001812 minor groove reading motif; other site 861360001813 helix-hairpin-helix signature motif; other site 861360001814 active site 861360001815 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 861360001816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360001817 dimerization interface [polypeptide binding]; other site 861360001818 putative DNA binding site [nucleotide binding]; other site 861360001819 putative Zn2+ binding site [ion binding]; other site 861360001820 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 861360001821 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 861360001822 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360001823 Walker A/P-loop; other site 861360001824 ATP binding site [chemical binding]; other site 861360001825 Q-loop/lid; other site 861360001826 ABC transporter signature motif; other site 861360001827 Walker B; other site 861360001828 D-loop; other site 861360001829 H-loop/switch region; other site 861360001830 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 861360001831 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 861360001832 FtsX-like permease family; Region: FtsX; pfam02687 861360001833 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 861360001834 FtsX-like permease family; Region: FtsX; pfam02687 861360001835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 861360001836 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 861360001837 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 861360001838 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 861360001839 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 861360001840 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 861360001841 putative active site [active] 861360001842 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 861360001843 RNase_H superfamily; Region: RNase_H_2; pfam13482 861360001844 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 861360001845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360001846 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 861360001847 Walker A motif; other site 861360001848 ATP binding site [chemical binding]; other site 861360001849 ATP binding site [chemical binding]; other site 861360001850 putative Mg++ binding site [ion binding]; other site 861360001851 AAA domain; Region: AAA_12; pfam13087 861360001852 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 861360001853 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 861360001854 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 861360001855 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360001856 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 861360001857 CoA-transferase family III; Region: CoA_transf_3; pfam02515 861360001858 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 861360001859 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 861360001860 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 861360001861 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 861360001862 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 861360001863 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 861360001864 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 861360001865 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360001866 DinB superfamily; Region: DinB_2; pfam12867 861360001867 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 861360001868 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 861360001869 active site 861360001870 substrate binding site [chemical binding]; other site 861360001871 cosubstrate binding site; other site 861360001872 catalytic site [active] 861360001873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360001874 NAD(P) binding site [chemical binding]; other site 861360001875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360001876 active site 861360001877 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 861360001878 active site 861360001879 catalytic site [active] 861360001880 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 861360001881 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 861360001882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360001883 catalytic core [active] 861360001884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360001885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360001886 benzoate transport; Region: 2A0115; TIGR00895 861360001887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001888 putative substrate translocation pore; other site 861360001889 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 861360001890 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 861360001891 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 861360001892 purine monophosphate binding site [chemical binding]; other site 861360001893 dimer interface [polypeptide binding]; other site 861360001894 putative catalytic residues [active] 861360001895 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 861360001896 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 861360001897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360001898 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 861360001899 Walker A/P-loop; other site 861360001900 ATP binding site [chemical binding]; other site 861360001901 Q-loop/lid; other site 861360001902 ABC transporter signature motif; other site 861360001903 Walker B; other site 861360001904 D-loop; other site 861360001905 H-loop/switch region; other site 861360001906 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360001907 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360001908 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 861360001909 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 861360001910 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 861360001911 hypothetical protein; Provisional; Region: PRK05463 861360001912 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 861360001913 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 861360001914 active site 861360001915 purine riboside binding site [chemical binding]; other site 861360001916 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360001917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360001918 DNA-binding site [nucleotide binding]; DNA binding site 861360001919 FCD domain; Region: FCD; pfam07729 861360001920 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 861360001921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360001922 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 861360001923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 861360001924 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 861360001925 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 861360001926 carboxyltransferase (CT) interaction site; other site 861360001927 biotinylation site [posttranslational modification]; other site 861360001928 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 861360001929 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 861360001930 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 861360001931 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 861360001932 putative active site [active] 861360001933 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 861360001934 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 861360001935 Potassium binding sites [ion binding]; other site 861360001936 Cesium cation binding sites [ion binding]; other site 861360001937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360001938 putative transporter; Provisional; Region: PRK10504 861360001939 putative substrate translocation pore; other site 861360001940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360001941 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 861360001942 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 861360001943 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 861360001944 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 861360001945 active site 861360001946 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 861360001947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 861360001948 Zn2+ binding site [ion binding]; other site 861360001949 Mg2+ binding site [ion binding]; other site 861360001950 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 861360001951 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 861360001952 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 861360001953 putative ligand binding site [chemical binding]; other site 861360001954 putative NAD binding site [chemical binding]; other site 861360001955 catalytic site [active] 861360001956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 861360001957 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 861360001958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 861360001959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360001960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360001961 DNA binding residues [nucleotide binding] 861360001962 dimerization interface [polypeptide binding]; other site 861360001963 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 861360001964 tetramer interface [polypeptide binding]; other site 861360001965 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 861360001966 active site 861360001967 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 861360001968 active site 861360001969 dimer interface [polypeptide binding]; other site 861360001970 magnesium binding site [ion binding]; other site 861360001971 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 861360001972 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 861360001973 ligand binding site [chemical binding]; other site 861360001974 flexible hinge region; other site 861360001975 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 861360001976 putative switch regulator; other site 861360001977 non-specific DNA interactions [nucleotide binding]; other site 861360001978 DNA binding site [nucleotide binding] 861360001979 sequence specific DNA binding site [nucleotide binding]; other site 861360001980 putative cAMP binding site [chemical binding]; other site 861360001981 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 861360001982 metal-binding site [ion binding] 861360001983 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 861360001984 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360001985 Soluble P-type ATPase [General function prediction only]; Region: COG4087 861360001986 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 861360001987 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 861360001988 Domain of unknown function (DUF305); Region: DUF305; pfam03713 861360001989 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 861360001990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360001991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360001992 motif II; other site 861360001993 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 861360001994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360001995 Soluble P-type ATPase [General function prediction only]; Region: COG4087 861360001996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360001997 dimerization interface [polypeptide binding]; other site 861360001998 putative DNA binding site [nucleotide binding]; other site 861360001999 putative Zn2+ binding site [ion binding]; other site 861360002000 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 861360002001 Fic/DOC family; Region: Fic; cl00960 861360002002 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360002003 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360002004 catalytic residues [active] 861360002005 catalytic nucleophile [active] 861360002006 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360002007 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360002008 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360002009 Synaptic Site I dimer interface [polypeptide binding]; other site 861360002010 DNA binding site [nucleotide binding] 861360002011 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360002012 DNA-binding interface [nucleotide binding]; DNA binding site 861360002013 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 861360002014 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 861360002015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360002016 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 861360002017 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 861360002018 putative active site [active] 861360002019 putative NTP binding site [chemical binding]; other site 861360002020 putative nucleic acid binding site [nucleotide binding]; other site 861360002021 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 861360002022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360002023 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360002025 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360002026 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 861360002027 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 861360002028 methionine synthase; Provisional; Region: PRK01207 861360002029 substrate binding site [chemical binding]; other site 861360002030 THF binding site; other site 861360002031 zinc-binding site [ion binding]; other site 861360002032 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 861360002033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360002034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360002035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 861360002036 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 861360002037 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 861360002038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360002039 catalytic residue [active] 861360002040 cystathionine gamma-synthase; Provisional; Region: PRK07811 861360002041 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 861360002042 homodimer interface [polypeptide binding]; other site 861360002043 substrate-cofactor binding pocket; other site 861360002044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360002045 catalytic residue [active] 861360002046 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 861360002047 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 861360002048 trimer interface [polypeptide binding]; other site 861360002049 putative metal binding site [ion binding]; other site 861360002050 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 861360002051 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 861360002052 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 861360002053 putative active site [active] 861360002054 putative substrate binding site [chemical binding]; other site 861360002055 putative cosubstrate binding site; other site 861360002056 catalytic site [active] 861360002057 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 861360002058 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 861360002059 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 861360002060 homodimer interface [polypeptide binding]; other site 861360002061 NADP binding site [chemical binding]; other site 861360002062 substrate binding site [chemical binding]; other site 861360002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360002064 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360002065 putative substrate translocation pore; other site 861360002066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360002067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360002068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 861360002069 dimerization interface [polypeptide binding]; other site 861360002070 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360002071 active site 861360002072 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360002073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360002074 active site 861360002075 phosphorylation site [posttranslational modification] 861360002076 intermolecular recognition site; other site 861360002077 dimerization interface [polypeptide binding]; other site 861360002078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360002079 DNA binding residues [nucleotide binding] 861360002080 dimerization interface [polypeptide binding]; other site 861360002081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360002082 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 861360002083 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 861360002084 putative active site [active] 861360002085 putative catalytic site [active] 861360002086 putative DNA binding site [nucleotide binding]; other site 861360002087 putative phosphate binding site [ion binding]; other site 861360002088 metal binding site A [ion binding]; metal-binding site 861360002089 putative AP binding site [nucleotide binding]; other site 861360002090 putative metal binding site B [ion binding]; other site 861360002091 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 861360002092 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 861360002093 active site 861360002094 HIGH motif; other site 861360002095 dimer interface [polypeptide binding]; other site 861360002096 KMSKS motif; other site 861360002097 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360002098 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 861360002099 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 861360002100 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 861360002101 tetramer interface [polypeptide binding]; other site 861360002102 heme binding pocket [chemical binding]; other site 861360002103 NADPH binding site [chemical binding]; other site 861360002104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360002105 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002106 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360002107 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360002108 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360002109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360002110 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002111 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 861360002112 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 861360002113 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 861360002114 L-aspartate oxidase; Provisional; Region: PRK06175 861360002115 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 861360002116 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 861360002117 putative Iron-sulfur protein interface [polypeptide binding]; other site 861360002118 putative proximal heme binding site [chemical binding]; other site 861360002119 putative SdhC-like subunit interface [polypeptide binding]; other site 861360002120 putative distal heme binding site [chemical binding]; other site 861360002121 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 861360002122 putative Iron-sulfur protein interface [polypeptide binding]; other site 861360002123 putative proximal heme binding site [chemical binding]; other site 861360002124 putative SdhD-like interface [polypeptide binding]; other site 861360002125 putative distal heme binding site [chemical binding]; other site 861360002126 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 861360002127 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 861360002128 Substrate binding site; other site 861360002129 BCCT family transporter; Region: BCCT; cl00569 861360002130 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 861360002131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360002132 NAD(P) binding site [chemical binding]; other site 861360002133 catalytic residues [active] 861360002134 choline dehydrogenase; Validated; Region: PRK02106 861360002135 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 861360002136 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 861360002137 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 861360002138 metal binding site [ion binding]; metal-binding site 861360002139 putative dimer interface [polypeptide binding]; other site 861360002140 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 861360002141 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 861360002142 ligand binding site [chemical binding]; other site 861360002143 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 861360002144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360002145 Walker A/P-loop; other site 861360002146 ATP binding site [chemical binding]; other site 861360002147 Q-loop/lid; other site 861360002148 ABC transporter signature motif; other site 861360002149 Walker B; other site 861360002150 D-loop; other site 861360002151 H-loop/switch region; other site 861360002152 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 861360002153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 861360002154 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 861360002155 TM-ABC transporter signature motif; other site 861360002156 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 861360002157 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 861360002158 TM-ABC transporter signature motif; other site 861360002159 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 861360002160 active site 861360002161 catalytic motif [active] 861360002162 Zn binding site [ion binding]; other site 861360002163 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 861360002164 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 861360002165 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 861360002166 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 861360002167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 861360002168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 861360002169 adenosine deaminase; Provisional; Region: PRK09358 861360002170 active site 861360002171 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 861360002172 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360002173 NAD(P) binding site [chemical binding]; other site 861360002174 catalytic residues [active] 861360002175 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 861360002176 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 861360002177 homodimer interface [polypeptide binding]; other site 861360002178 metal binding site [ion binding]; metal-binding site 861360002179 enolase; Provisional; Region: eno; PRK00077 861360002180 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 861360002181 dimer interface [polypeptide binding]; other site 861360002182 metal binding site [ion binding]; metal-binding site 861360002183 substrate binding pocket [chemical binding]; other site 861360002184 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 861360002185 Septum formation initiator; Region: DivIC; pfam04977 861360002186 Protein of unknown function (DUF501); Region: DUF501; pfam04417 861360002187 exopolyphosphatase; Region: exo_poly_only; TIGR03706 861360002188 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 861360002189 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 861360002190 active site 861360002191 catalytic residues [active] 861360002192 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 861360002193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360002194 Bax inhibitor 1 like; Region: BaxI_1; cl17691 861360002195 amino acid transporter; Region: 2A0306; TIGR00909 861360002196 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 861360002197 Domain of unknown function DUF20; Region: UPF0118; pfam01594 861360002198 threonine dehydratase; Provisional; Region: PRK08198 861360002199 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 861360002200 tetramer interface [polypeptide binding]; other site 861360002201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360002202 catalytic residue [active] 861360002203 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 861360002204 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 861360002205 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 861360002206 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 861360002207 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 861360002208 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 861360002209 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 861360002210 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 861360002211 catalytic residues [active] 861360002212 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 861360002213 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 861360002214 catalytic residue [active] 861360002215 putative FPP diphosphate binding site; other site 861360002216 putative FPP binding hydrophobic cleft; other site 861360002217 dimer interface [polypeptide binding]; other site 861360002218 putative IPP diphosphate binding site; other site 861360002219 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 861360002220 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 861360002221 putative active site [active] 861360002222 PhoH-like protein; Region: PhoH; pfam02562 861360002223 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 861360002224 nudix motif; other site 861360002225 fumarate hydratase; Reviewed; Region: fumC; PRK00485 861360002226 Class II fumarases; Region: Fumarase_classII; cd01362 861360002227 active site 861360002228 tetramer interface [polypeptide binding]; other site 861360002229 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 861360002230 active site clefts [active] 861360002231 zinc binding site [ion binding]; other site 861360002232 dimer interface [polypeptide binding]; other site 861360002233 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 861360002234 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 861360002235 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 861360002236 putative active site [active] 861360002237 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 861360002238 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 861360002239 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 861360002240 Transcriptional regulator [Transcription]; Region: LytR; COG1316 861360002241 AIR carboxylase; Region: AIRC; pfam00731 861360002242 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 861360002243 ATP-grasp domain; Region: ATP-grasp; pfam02222 861360002244 Predicted membrane protein [Function unknown]; Region: COG2246 861360002245 GtrA-like protein; Region: GtrA; pfam04138 861360002246 TIGR03089 family protein; Region: TIGR03089 861360002247 Transcription factor WhiB; Region: Whib; pfam02467 861360002248 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 861360002249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 861360002250 active site 861360002251 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 861360002252 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 861360002253 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 861360002254 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 861360002255 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 861360002256 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 861360002257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360002258 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 861360002259 acyl-activating enzyme (AAE) consensus motif; other site 861360002260 putative AMP binding site [chemical binding]; other site 861360002261 putative active site [active] 861360002262 putative CoA binding site [chemical binding]; other site 861360002263 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 861360002264 Predicted methyltransferases [General function prediction only]; Region: COG0313 861360002265 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 861360002266 putative SAM binding site [chemical binding]; other site 861360002267 putative homodimer interface [polypeptide binding]; other site 861360002268 succinic semialdehyde dehydrogenase; Region: PLN02278 861360002269 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 861360002270 tetramerization interface [polypeptide binding]; other site 861360002271 NAD(P) binding site [chemical binding]; other site 861360002272 catalytic residues [active] 861360002273 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 861360002274 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 861360002275 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 861360002276 Protein of unknown function DUF58; Region: DUF58; pfam01882 861360002277 MoxR-like ATPases [General function prediction only]; Region: COG0714 861360002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360002279 Walker A motif; other site 861360002280 ATP binding site [chemical binding]; other site 861360002281 Walker B motif; other site 861360002282 arginine finger; other site 861360002283 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 861360002284 active site 861360002285 Domain of unknown function (DUF348); Region: DUF348; pfam03990 861360002286 Domain of unknown function (DUF348); Region: DUF348; pfam03990 861360002287 Domain of unknown function (DUF348); Region: DUF348; pfam03990 861360002288 G5 domain; Region: G5; pfam07501 861360002289 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 861360002290 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 861360002291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360002292 S-adenosylmethionine binding site [chemical binding]; other site 861360002293 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 861360002294 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 861360002295 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 861360002296 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 861360002297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 861360002298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 861360002299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002300 Coenzyme A binding pocket [chemical binding]; other site 861360002301 Uncharacterized conserved protein [Function unknown]; Region: COG1359 861360002302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360002303 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360002304 ABC transporter; Region: ABC_tran_2; pfam12848 861360002305 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360002306 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 861360002307 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 861360002308 Substrate binding site; other site 861360002309 Mg++ binding site; other site 861360002310 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 861360002311 active site 861360002312 substrate binding site [chemical binding]; other site 861360002313 CoA binding site [chemical binding]; other site 861360002314 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 861360002315 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 861360002316 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360002317 active site 861360002318 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360002319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360002320 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360002322 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 861360002323 Walker A/P-loop; other site 861360002324 ATP binding site [chemical binding]; other site 861360002325 Q-loop/lid; other site 861360002326 ABC transporter signature motif; other site 861360002327 Walker B; other site 861360002328 D-loop; other site 861360002329 H-loop/switch region; other site 861360002330 Transposase; Region: HTH_Tnp_1; pfam01527 861360002331 HTH-like domain; Region: HTH_21; pfam13276 861360002332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360002333 Integrase core domain; Region: rve; pfam00665 861360002334 Integrase core domain; Region: rve_3; pfam13683 861360002335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360002336 Walker A motif; other site 861360002337 ATP binding site [chemical binding]; other site 861360002338 Walker B motif; other site 861360002339 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 861360002340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 861360002341 Integrase core domain; Region: rve; pfam00665 861360002342 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 861360002343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360002344 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002345 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360002346 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002347 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360002348 catalytic residues [active] 861360002349 catalytic nucleophile [active] 861360002350 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360002351 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360002352 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360002353 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360002354 Synaptic Site I dimer interface [polypeptide binding]; other site 861360002355 DNA binding site [nucleotide binding] 861360002356 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360002357 DNA-binding interface [nucleotide binding]; DNA binding site 861360002358 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 861360002359 5S rRNA interface [nucleotide binding]; other site 861360002360 CTC domain interface [polypeptide binding]; other site 861360002361 L16 interface [polypeptide binding]; other site 861360002362 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 861360002363 putative active site [active] 861360002364 catalytic residue [active] 861360002365 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 861360002366 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 861360002367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360002368 catalytic residue [active] 861360002369 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 861360002370 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 861360002371 trimerization site [polypeptide binding]; other site 861360002372 active site 861360002373 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 861360002374 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 861360002375 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 861360002376 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 861360002377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360002378 ATP binding site [chemical binding]; other site 861360002379 putative Mg++ binding site [ion binding]; other site 861360002380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360002381 nucleotide binding region [chemical binding]; other site 861360002382 ATP-binding site [chemical binding]; other site 861360002383 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 861360002384 Tetratrico peptide repeat; Region: TPR_5; pfam12688 861360002385 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 861360002386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360002387 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 861360002388 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 861360002389 intersubunit interface [polypeptide binding]; other site 861360002390 active site 861360002391 catalytic residue [active] 861360002392 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 861360002393 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 861360002394 active site 861360002395 substrate binding site [chemical binding]; other site 861360002396 metal binding site [ion binding]; metal-binding site 861360002397 purine nucleoside phosphorylase; Provisional; Region: PRK08202 861360002398 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 861360002399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360002400 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 861360002401 MULE transposase domain; Region: MULE; pfam10551 861360002402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360002403 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360002404 putative substrate translocation pore; other site 861360002405 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 861360002406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360002407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 861360002408 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 861360002409 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 861360002410 carboxyltransferase (CT) interaction site; other site 861360002411 biotinylation site [posttranslational modification]; other site 861360002412 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360002413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 861360002414 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360002415 CGNR zinc finger; Region: zf-CGNR; pfam11706 861360002416 Maf-like protein; Region: Maf; pfam02545 861360002417 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 861360002418 active site 861360002419 dimer interface [polypeptide binding]; other site 861360002420 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 861360002421 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 861360002422 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 861360002423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360002424 Winged helix-turn helix; Region: HTH_29; pfam13551 861360002425 Homeodomain-like domain; Region: HTH_32; pfam13565 861360002426 Integrase core domain; Region: rve; pfam00665 861360002427 DDE domain; Region: DDE_Tnp_IS240; pfam13610 861360002428 Integrase core domain; Region: rve_3; pfam13683 861360002429 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360002430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360002431 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002432 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 861360002433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360002434 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 861360002435 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 861360002436 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 861360002437 Interdomain contacts; other site 861360002438 Cytokine receptor motif; other site 861360002439 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 861360002440 Interdomain contacts; other site 861360002441 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 861360002442 Interdomain contacts; other site 861360002443 Cytokine receptor motif; other site 861360002444 MoxR-like ATPases [General function prediction only]; Region: COG0714 861360002445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360002446 Walker A motif; other site 861360002447 ATP binding site [chemical binding]; other site 861360002448 Walker B motif; other site 861360002449 arginine finger; other site 861360002450 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 861360002451 Protein of unknown function DUF58; Region: DUF58; pfam01882 861360002452 RDD family; Region: RDD; pfam06271 861360002453 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 861360002454 active site 861360002455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 861360002456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 861360002457 active site 861360002458 ATP binding site [chemical binding]; other site 861360002459 substrate binding site [chemical binding]; other site 861360002460 activation loop (A-loop); other site 861360002461 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 861360002462 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 861360002463 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 861360002464 short chain dehydrogenase; Provisional; Region: PRK08278 861360002465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360002466 NAD(P) binding site [chemical binding]; other site 861360002467 active site 861360002468 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 861360002469 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 861360002470 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 861360002471 cyclase homology domain; Region: CHD; cd07302 861360002472 nucleotidyl binding site; other site 861360002473 metal binding site [ion binding]; metal-binding site 861360002474 dimer interface [polypeptide binding]; other site 861360002475 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 861360002476 active site 861360002477 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 861360002478 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 861360002479 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 861360002480 nucleotide binding pocket [chemical binding]; other site 861360002481 K-X-D-G motif; other site 861360002482 catalytic site [active] 861360002483 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 861360002484 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 861360002485 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 861360002486 Dimer interface [polypeptide binding]; other site 861360002487 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 861360002488 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 861360002489 active site 861360002490 dimerization interface [polypeptide binding]; other site 861360002491 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 861360002492 putative hydrophobic ligand binding site [chemical binding]; other site 861360002493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360002494 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 861360002495 non-specific DNA interactions [nucleotide binding]; other site 861360002496 DNA binding site [nucleotide binding] 861360002497 sequence specific DNA binding site [nucleotide binding]; other site 861360002498 putative cAMP binding site [chemical binding]; other site 861360002499 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360002500 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360002501 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360002502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002503 Coenzyme A binding pocket [chemical binding]; other site 861360002504 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 861360002505 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 861360002506 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 861360002507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360002508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360002509 glycogen branching enzyme; Provisional; Region: PRK14705 861360002510 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 861360002511 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 861360002512 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 861360002513 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 861360002514 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 861360002515 GatB domain; Region: GatB_Yqey; smart00845 861360002516 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360002517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360002518 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360002519 Phosphotransferase enzyme family; Region: APH; pfam01636 861360002520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 861360002521 active site 861360002522 substrate binding site [chemical binding]; other site 861360002523 ATP binding site [chemical binding]; other site 861360002524 SdpI/YhfL protein family; Region: SdpI; pfam13630 861360002525 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 861360002526 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360002527 MarR family; Region: MarR_2; pfam12802 861360002528 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 861360002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360002530 putative substrate translocation pore; other site 861360002531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360002532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360002533 active site 861360002534 catalytic tetrad [active] 861360002535 Uncharacterized conserved protein [Function unknown]; Region: COG1262 861360002536 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 861360002537 SnoaL-like domain; Region: SnoaL_2; pfam12680 861360002538 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360002539 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360002540 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 861360002541 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 861360002542 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 861360002543 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360002544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002545 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360002546 Coenzyme A binding pocket [chemical binding]; other site 861360002547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002548 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360002549 Coenzyme A binding pocket [chemical binding]; other site 861360002550 Uncharacterized conserved protein (DUF2045); Region: DUF2045; pfam09741 861360002551 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360002552 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 861360002553 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 861360002554 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360002555 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 861360002556 active site 861360002557 ATP binding site [chemical binding]; other site 861360002558 substrate binding site [chemical binding]; other site 861360002559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360002560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360002561 putative DNA binding site [nucleotide binding]; other site 861360002562 putative Zn2+ binding site [ion binding]; other site 861360002563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 861360002564 dimerization interface [polypeptide binding]; other site 861360002565 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 861360002566 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 861360002567 NAD(P) binding site [chemical binding]; other site 861360002568 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 861360002569 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 861360002570 substrate-cofactor binding pocket; other site 861360002571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360002572 catalytic residue [active] 861360002573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360002574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360002575 DNA binding site [nucleotide binding] 861360002576 domain linker motif; other site 861360002577 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 861360002578 dimerization interface [polypeptide binding]; other site 861360002579 ligand binding site [chemical binding]; other site 861360002580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 861360002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002582 dimer interface [polypeptide binding]; other site 861360002583 conserved gate region; other site 861360002584 putative PBP binding loops; other site 861360002585 ABC-ATPase subunit interface; other site 861360002586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 861360002587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002588 dimer interface [polypeptide binding]; other site 861360002589 conserved gate region; other site 861360002590 putative PBP binding loops; other site 861360002591 ABC-ATPase subunit interface; other site 861360002592 imidazolonepropionase; Provisional; Region: PRK14085 861360002593 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 861360002594 active site 861360002595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360002596 S-adenosylmethionine binding site [chemical binding]; other site 861360002597 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 861360002598 dimer interface [polypeptide binding]; other site 861360002599 catalytic triad [active] 861360002600 peroxidatic and resolving cysteines [active] 861360002601 Phosphotransferase enzyme family; Region: APH; pfam01636 861360002602 Phosphotransferase enzyme family; Region: APH; pfam01636 861360002603 CAAX protease self-immunity; Region: Abi; pfam02517 861360002604 putative acetyltransferase; Provisional; Region: PRK03624 861360002605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002606 Coenzyme A binding pocket [chemical binding]; other site 861360002607 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 861360002608 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 861360002609 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 861360002610 homodimer interface [polypeptide binding]; other site 861360002611 substrate-cofactor binding pocket; other site 861360002612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360002613 catalytic residue [active] 861360002614 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 861360002615 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 861360002616 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 861360002617 active site 861360002618 catalytic triad [active] 861360002619 oxyanion hole [active] 861360002620 Predicted transcriptional regulators [Transcription]; Region: COG1725 861360002621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360002622 DNA-binding site [nucleotide binding]; DNA binding site 861360002623 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 861360002624 putative hydrolase; Provisional; Region: PRK11460 861360002625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360002626 RNA binding surface [nucleotide binding]; other site 861360002627 glycyl-tRNA synthetase; Provisional; Region: PRK04173 861360002628 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 861360002629 motif 1; other site 861360002630 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 861360002631 motif 1; other site 861360002632 dimer interface [polypeptide binding]; other site 861360002633 active site 861360002634 motif 2; other site 861360002635 motif 3; other site 861360002636 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 861360002637 anticodon binding site; other site 861360002638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360002639 Coenzyme A binding pocket [chemical binding]; other site 861360002640 Protein of unknown function, DUF606; Region: DUF606; pfam04657 861360002641 Protein of unknown function, DUF606; Region: DUF606; pfam04657 861360002642 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 861360002643 Chromate transporter; Region: Chromate_transp; pfam02417 861360002644 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 861360002645 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 861360002646 FMN binding site [chemical binding]; other site 861360002647 active site 861360002648 catalytic residues [active] 861360002649 substrate binding site [chemical binding]; other site 861360002650 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 861360002651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 861360002652 Zn2+ binding site [ion binding]; other site 861360002653 Mg2+ binding site [ion binding]; other site 861360002654 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 861360002655 DNA primase; Validated; Region: dnaG; PRK05667 861360002656 CHC2 zinc finger; Region: zf-CHC2; pfam01807 861360002657 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 861360002658 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 861360002659 active site 861360002660 metal binding site [ion binding]; metal-binding site 861360002661 interdomain interaction site; other site 861360002662 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 861360002663 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 861360002664 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 861360002665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 861360002666 dimerization interface [polypeptide binding]; other site 861360002667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360002668 ATP binding site [chemical binding]; other site 861360002669 Mg2+ binding site [ion binding]; other site 861360002670 G-X-G motif; other site 861360002671 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 861360002672 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 861360002673 pentamer interface [polypeptide binding]; other site 861360002674 dodecaamer interface [polypeptide binding]; other site 861360002675 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 861360002676 active site 861360002677 homopentamer interface [polypeptide binding]; other site 861360002678 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 861360002679 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 861360002680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360002681 non-specific DNA binding site [nucleotide binding]; other site 861360002682 salt bridge; other site 861360002683 sequence-specific DNA binding site [nucleotide binding]; other site 861360002684 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 861360002685 active site 861360002686 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 861360002687 AAA domain; Region: AAA_26; pfam13500 861360002688 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 861360002689 Cytochrome P450; Region: p450; cl12078 861360002690 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 861360002691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360002692 catalytic residue [active] 861360002693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360002694 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 861360002695 inhibitor-cofactor binding pocket; inhibition site 861360002696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360002697 catalytic residue [active] 861360002698 biotin synthase; Validated; Region: PRK06256 861360002699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360002700 FeS/SAM binding site; other site 861360002701 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 861360002702 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 861360002703 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 861360002704 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 861360002705 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360002706 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 861360002707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 861360002708 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 861360002709 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 861360002710 IucA / IucC family; Region: IucA_IucC; pfam04183 861360002711 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 861360002712 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 861360002713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360002714 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 861360002715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360002716 catalytic residue [active] 861360002717 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360002718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360002719 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 861360002720 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 861360002721 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 861360002722 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 861360002723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360002724 putative ADP-binding pocket [chemical binding]; other site 861360002725 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360002726 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360002727 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 861360002728 rRNA interaction site [nucleotide binding]; other site 861360002729 S8 interaction site; other site 861360002730 putative laminin-1 binding site; other site 861360002731 elongation factor Ts; Provisional; Region: tsf; PRK09377 861360002732 UBA/TS-N domain; Region: UBA; pfam00627 861360002733 Elongation factor TS; Region: EF_TS; pfam00889 861360002734 Elongation factor TS; Region: EF_TS; pfam00889 861360002735 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 861360002736 putative nucleotide binding site [chemical binding]; other site 861360002737 uridine monophosphate binding site [chemical binding]; other site 861360002738 homohexameric interface [polypeptide binding]; other site 861360002739 ribosome recycling factor; Reviewed; Region: frr; PRK00083 861360002740 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 861360002741 hinge region; other site 861360002742 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 861360002743 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 861360002744 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 861360002745 DivIVA domain; Region: DivI1A_domain; TIGR03544 861360002746 DivIVA domain; Region: DivI1A_domain; TIGR03544 861360002747 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 861360002748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360002749 DNA-binding site [nucleotide binding]; DNA binding site 861360002750 FCD domain; Region: FCD; pfam07729 861360002751 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 861360002752 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 861360002753 Na binding site [ion binding]; other site 861360002754 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 861360002755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360002756 active site 861360002757 phosphorylation site [posttranslational modification] 861360002758 intermolecular recognition site; other site 861360002759 dimerization interface [polypeptide binding]; other site 861360002760 LytTr DNA-binding domain; Region: LytTR; smart00850 861360002761 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 861360002762 Histidine kinase; Region: His_kinase; pfam06580 861360002763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360002764 ATP binding site [chemical binding]; other site 861360002765 Mg2+ binding site [ion binding]; other site 861360002766 G-X-G motif; other site 861360002767 Protein of unknown function, DUF485; Region: DUF485; pfam04341 861360002768 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 861360002769 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 861360002770 Na binding site [ion binding]; other site 861360002771 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360002772 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 861360002773 AsnC family; Region: AsnC_trans_reg; pfam01037 861360002774 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 861360002775 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 861360002776 TPP-binding site [chemical binding]; other site 861360002777 heterodimer interface [polypeptide binding]; other site 861360002778 tetramer interface [polypeptide binding]; other site 861360002779 phosphorylation loop region [posttranslational modification] 861360002780 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 861360002781 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 861360002782 alpha subunit interface [polypeptide binding]; other site 861360002783 TPP binding site [chemical binding]; other site 861360002784 heterodimer interface [polypeptide binding]; other site 861360002785 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360002786 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 861360002787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360002788 E3 interaction surface; other site 861360002789 lipoyl attachment site [posttranslational modification]; other site 861360002790 e3 binding domain; Region: E3_binding; pfam02817 861360002791 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 861360002792 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 861360002793 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360002794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002796 dimer interface [polypeptide binding]; other site 861360002797 conserved gate region; other site 861360002798 ABC-ATPase subunit interface; other site 861360002799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 861360002800 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 861360002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002802 dimer interface [polypeptide binding]; other site 861360002803 conserved gate region; other site 861360002804 putative PBP binding loops; other site 861360002805 ABC-ATPase subunit interface; other site 861360002806 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360002807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360002808 Walker A/P-loop; other site 861360002809 ATP binding site [chemical binding]; other site 861360002810 Q-loop/lid; other site 861360002811 ABC transporter signature motif; other site 861360002812 Walker B; other site 861360002813 D-loop; other site 861360002814 H-loop/switch region; other site 861360002815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 861360002816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360002817 Walker A/P-loop; other site 861360002818 ATP binding site [chemical binding]; other site 861360002819 Q-loop/lid; other site 861360002820 ABC transporter signature motif; other site 861360002821 Walker B; other site 861360002822 D-loop; other site 861360002823 H-loop/switch region; other site 861360002824 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360002825 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 861360002826 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 861360002827 putative active site [active] 861360002828 putative NTP binding site [chemical binding]; other site 861360002829 putative nucleic acid binding site [nucleotide binding]; other site 861360002830 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 861360002831 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 861360002832 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360002833 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360002834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002836 putative PBP binding loops; other site 861360002837 dimer interface [polypeptide binding]; other site 861360002838 ABC-ATPase subunit interface; other site 861360002839 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 861360002840 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 861360002841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360002842 dimer interface [polypeptide binding]; other site 861360002843 conserved gate region; other site 861360002844 putative PBP binding loops; other site 861360002845 ABC-ATPase subunit interface; other site 861360002846 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360002847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360002848 Walker A/P-loop; other site 861360002849 ATP binding site [chemical binding]; other site 861360002850 Q-loop/lid; other site 861360002851 ABC transporter signature motif; other site 861360002852 Walker B; other site 861360002853 D-loop; other site 861360002854 H-loop/switch region; other site 861360002855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360002856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360002857 Walker A/P-loop; other site 861360002858 ATP binding site [chemical binding]; other site 861360002859 Q-loop/lid; other site 861360002860 ABC transporter signature motif; other site 861360002861 Walker B; other site 861360002862 D-loop; other site 861360002863 H-loop/switch region; other site 861360002864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360002865 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 861360002866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360002867 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360002868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360002869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360002870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360002871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360002872 active site 861360002873 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 861360002874 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 861360002875 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 861360002876 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 861360002877 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 861360002878 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 861360002879 active site 861360002880 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 861360002881 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 861360002882 putative substrate binding region [chemical binding]; other site 861360002883 YCII-related domain; Region: YCII; cl00999 861360002884 hypothetical protein; Provisional; Region: PRK09256 861360002885 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 861360002886 Predicted flavoprotein [General function prediction only]; Region: COG0431 861360002887 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 861360002888 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 861360002889 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 861360002890 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 861360002891 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360002892 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 861360002893 DNA binding site [nucleotide binding] 861360002894 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 861360002895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360002896 prolyl-tRNA synthetase; Provisional; Region: PRK09194 861360002897 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 861360002898 dimer interface [polypeptide binding]; other site 861360002899 motif 1; other site 861360002900 active site 861360002901 motif 2; other site 861360002902 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 861360002903 putative deacylase active site [active] 861360002904 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 861360002905 active site 861360002906 motif 3; other site 861360002907 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 861360002908 anticodon binding site; other site 861360002909 hypothetical protein; Provisional; Region: PRK10621 861360002910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 861360002911 Winged helix-turn helix; Region: HTH_29; pfam13551 861360002912 DDE superfamily endonuclease; Region: DDE_3; pfam13358 861360002913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 861360002914 ribosome maturation protein RimP; Reviewed; Region: PRK00092 861360002915 Sm and related proteins; Region: Sm_like; cl00259 861360002916 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 861360002917 putative oligomer interface [polypeptide binding]; other site 861360002918 putative RNA binding site [nucleotide binding]; other site 861360002919 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 861360002920 NusA N-terminal domain; Region: NusA_N; pfam08529 861360002921 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 861360002922 RNA binding site [nucleotide binding]; other site 861360002923 homodimer interface [polypeptide binding]; other site 861360002924 NusA-like KH domain; Region: KH_5; pfam13184 861360002925 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 861360002926 G-X-X-G motif; other site 861360002927 Protein of unknown function (DUF448); Region: DUF448; pfam04296 861360002928 putative RNA binding cleft [nucleotide binding]; other site 861360002929 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 861360002930 translation initiation factor IF-2; Region: IF-2; TIGR00487 861360002931 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 861360002932 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 861360002933 G1 box; other site 861360002934 putative GEF interaction site [polypeptide binding]; other site 861360002935 GTP/Mg2+ binding site [chemical binding]; other site 861360002936 Switch I region; other site 861360002937 G2 box; other site 861360002938 G3 box; other site 861360002939 Switch II region; other site 861360002940 G4 box; other site 861360002941 G5 box; other site 861360002942 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 861360002943 Translation-initiation factor 2; Region: IF-2; pfam11987 861360002944 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 861360002945 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 861360002946 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 861360002947 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 861360002948 MarR family; Region: MarR; pfam01047 861360002949 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 861360002950 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 861360002951 Moco binding site; other site 861360002952 metal coordination site [ion binding]; other site 861360002953 Anti-sigma-K factor rskA; Region: RskA; pfam10099 861360002954 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 861360002955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360002956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360002957 DNA binding residues [nucleotide binding] 861360002958 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 861360002959 Fasciclin domain; Region: Fasciclin; pfam02469 861360002960 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 861360002961 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 861360002962 RNA binding site [nucleotide binding]; other site 861360002963 active site 861360002964 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 861360002965 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 861360002966 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 861360002967 active site 861360002968 Riboflavin kinase; Region: Flavokinase; pfam01687 861360002969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360002970 S-adenosylmethionine binding site [chemical binding]; other site 861360002971 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 861360002972 16S/18S rRNA binding site [nucleotide binding]; other site 861360002973 S13e-L30e interaction site [polypeptide binding]; other site 861360002974 25S rRNA binding site [nucleotide binding]; other site 861360002975 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 861360002976 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 861360002977 potential catalytic triad [active] 861360002978 conserved cys residue [active] 861360002979 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 861360002980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360002981 catalytic residue [active] 861360002982 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 861360002983 putative dimer interface [polypeptide binding]; other site 861360002984 catalytic triad [active] 861360002985 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 861360002986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 861360002987 Ligand Binding Site [chemical binding]; other site 861360002988 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 861360002989 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 861360002990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 861360002991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360002992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360002993 ATP binding site [chemical binding]; other site 861360002994 Mg2+ binding site [ion binding]; other site 861360002995 G-X-G motif; other site 861360002996 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 861360002997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360002998 active site 861360002999 phosphorylation site [posttranslational modification] 861360003000 intermolecular recognition site; other site 861360003001 dimerization interface [polypeptide binding]; other site 861360003002 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 861360003003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360003004 prephenate dehydratase; Provisional; Region: PRK11899 861360003005 Prephenate dehydratase; Region: PDT; pfam00800 861360003006 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 861360003007 putative L-Phe binding site [chemical binding]; other site 861360003008 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360003009 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 861360003010 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360003011 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 861360003012 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 861360003013 tetramer interface [polypeptide binding]; other site 861360003014 TPP-binding site [chemical binding]; other site 861360003015 heterodimer interface [polypeptide binding]; other site 861360003016 phosphorylation loop region [posttranslational modification] 861360003017 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 861360003018 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 861360003019 alpha subunit interface [polypeptide binding]; other site 861360003020 TPP binding site [chemical binding]; other site 861360003021 heterodimer interface [polypeptide binding]; other site 861360003022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360003023 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 861360003024 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360003025 E3 interaction surface; other site 861360003026 lipoyl attachment site [posttranslational modification]; other site 861360003027 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 861360003028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360003029 NAD(P) binding site [chemical binding]; other site 861360003030 active site 861360003031 haloalkane dehalogenase; Provisional; Region: PRK00870 861360003032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360003033 peptide synthase; Provisional; Region: PRK09274 861360003034 acyl-activating enzyme (AAE) consensus motif; other site 861360003035 AMP binding site [chemical binding]; other site 861360003036 active site 861360003037 CoA binding site [chemical binding]; other site 861360003038 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 861360003039 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 861360003040 dimer interface [polypeptide binding]; other site 861360003041 active site 861360003042 CoA binding pocket [chemical binding]; other site 861360003043 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 861360003044 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 861360003045 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 861360003046 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 861360003047 putative NAD(P) binding site [chemical binding]; other site 861360003048 putative substrate binding site [chemical binding]; other site 861360003049 catalytic Zn binding site [ion binding]; other site 861360003050 structural Zn binding site [ion binding]; other site 861360003051 dimer interface [polypeptide binding]; other site 861360003052 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 861360003053 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 861360003054 oligomer interface [polypeptide binding]; other site 861360003055 RNA binding site [nucleotide binding]; other site 861360003056 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 861360003057 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 861360003058 RNase E interface [polypeptide binding]; other site 861360003059 trimer interface [polypeptide binding]; other site 861360003060 active site 861360003061 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 861360003062 putative nucleic acid binding region [nucleotide binding]; other site 861360003063 G-X-X-G motif; other site 861360003064 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 861360003065 RNA binding site [nucleotide binding]; other site 861360003066 domain interface; other site 861360003067 Predicted membrane protein [Function unknown]; Region: COG4325 861360003068 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 861360003069 nucleosidase; Provisional; Region: PRK05634 861360003070 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 861360003071 S-ribosylhomocysteinase; Provisional; Region: PRK02260 861360003072 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 861360003073 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 861360003074 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 861360003075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360003076 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 861360003077 catalytic site [active] 861360003078 dihydrodipicolinate reductase; Provisional; Region: PRK00048 861360003079 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 861360003080 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 861360003081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 861360003082 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 861360003083 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 861360003084 dimer interface [polypeptide binding]; other site 861360003085 active site 861360003086 catalytic residue [active] 861360003087 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 861360003088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360003089 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 861360003090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 861360003091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003092 Walker A/P-loop; other site 861360003093 ATP binding site [chemical binding]; other site 861360003094 Q-loop/lid; other site 861360003095 ABC transporter signature motif; other site 861360003096 Walker B; other site 861360003097 D-loop; other site 861360003098 H-loop/switch region; other site 861360003099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360003100 dimer interface [polypeptide binding]; other site 861360003101 conserved gate region; other site 861360003102 putative PBP binding loops; other site 861360003103 ABC-ATPase subunit interface; other site 861360003104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360003105 ABC-ATPase subunit interface; other site 861360003106 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 861360003107 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 861360003108 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360003109 intersubunit interface [polypeptide binding]; other site 861360003110 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 861360003111 Methyltransferase domain; Region: Methyltransf_18; pfam12847 861360003112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 861360003113 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 861360003114 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360003115 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360003116 ABC-ATPase subunit interface; other site 861360003117 dimer interface [polypeptide binding]; other site 861360003118 putative PBP binding regions; other site 861360003119 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 861360003120 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 861360003121 Walker A/P-loop; other site 861360003122 ATP binding site [chemical binding]; other site 861360003123 Q-loop/lid; other site 861360003124 ABC transporter signature motif; other site 861360003125 Walker B; other site 861360003126 D-loop; other site 861360003127 H-loop/switch region; other site 861360003128 mycothione reductase; Reviewed; Region: PRK07846 861360003129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360003130 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 861360003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003132 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 861360003133 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 861360003134 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 861360003135 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 861360003136 Competence-damaged protein; Region: CinA; pfam02464 861360003137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360003138 non-specific DNA binding site [nucleotide binding]; other site 861360003139 salt bridge; other site 861360003140 sequence-specific DNA binding site [nucleotide binding]; other site 861360003141 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 861360003142 recombinase A; Provisional; Region: recA; PRK09354 861360003143 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 861360003144 hexamer interface [polypeptide binding]; other site 861360003145 Walker A motif; other site 861360003146 ATP binding site [chemical binding]; other site 861360003147 Walker B motif; other site 861360003148 recombination regulator RecX; Reviewed; Region: recX; PRK00117 861360003149 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 861360003150 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 861360003151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360003152 FeS/SAM binding site; other site 861360003153 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 861360003154 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 861360003155 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 861360003156 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 861360003157 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 861360003158 Winged helix-turn helix; Region: HTH_29; pfam13551 861360003159 Homeodomain-like domain; Region: HTH_32; pfam13565 861360003160 Integrase core domain; Region: rve; pfam00665 861360003161 DDE domain; Region: DDE_Tnp_IS240; pfam13610 861360003162 Integrase core domain; Region: rve_3; pfam13683 861360003163 TPR repeat; Region: TPR_11; pfam13414 861360003164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360003165 S-adenosylmethionine binding site [chemical binding]; other site 861360003166 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 861360003167 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 861360003168 HflX GTPase family; Region: HflX; cd01878 861360003169 G1 box; other site 861360003170 GTP/Mg2+ binding site [chemical binding]; other site 861360003171 Switch I region; other site 861360003172 G2 box; other site 861360003173 G3 box; other site 861360003174 Switch II region; other site 861360003175 G4 box; other site 861360003176 G5 box; other site 861360003177 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 861360003178 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 861360003179 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 861360003180 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 861360003181 LexA repressor; Validated; Region: PRK00215 861360003182 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 861360003183 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 861360003184 Catalytic site [active] 861360003185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360003186 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 861360003187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360003188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360003189 homodimer interface [polypeptide binding]; other site 861360003190 catalytic residue [active] 861360003191 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 861360003192 putative active site pocket [active] 861360003193 4-fold oligomerization interface [polypeptide binding]; other site 861360003194 metal binding residues [ion binding]; metal-binding site 861360003195 3-fold/trimer interface [polypeptide binding]; other site 861360003196 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 861360003197 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 861360003198 putative active site [active] 861360003199 oxyanion strand; other site 861360003200 catalytic triad [active] 861360003201 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 861360003202 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 861360003203 catalytic residues [active] 861360003204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360003205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003207 putative substrate translocation pore; other site 861360003208 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360003209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360003210 Coenzyme A binding pocket [chemical binding]; other site 861360003211 translation initiation factor IF-3; Region: infC; TIGR00168 861360003212 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 861360003213 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 861360003214 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 861360003215 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 861360003216 23S rRNA binding site [nucleotide binding]; other site 861360003217 L21 binding site [polypeptide binding]; other site 861360003218 L13 binding site [polypeptide binding]; other site 861360003219 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 861360003220 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 861360003221 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 861360003222 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 861360003223 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 861360003224 active site 861360003225 8-oxo-dGMP binding site [chemical binding]; other site 861360003226 nudix motif; other site 861360003227 metal binding site [ion binding]; metal-binding site 861360003228 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 861360003229 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 861360003230 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 861360003231 dimer interface [polypeptide binding]; other site 861360003232 motif 1; other site 861360003233 active site 861360003234 motif 2; other site 861360003235 motif 3; other site 861360003236 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 861360003237 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 861360003238 putative tRNA-binding site [nucleotide binding]; other site 861360003239 B3/4 domain; Region: B3_4; pfam03483 861360003240 tRNA synthetase B5 domain; Region: B5; smart00874 861360003241 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 861360003242 dimer interface [polypeptide binding]; other site 861360003243 motif 1; other site 861360003244 motif 3; other site 861360003245 motif 2; other site 861360003246 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 861360003247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360003248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360003249 Coenzyme A binding pocket [chemical binding]; other site 861360003250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360003251 Coenzyme A binding pocket [chemical binding]; other site 861360003252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360003253 active site 861360003254 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 861360003255 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 861360003256 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 861360003257 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 861360003258 Zn binding site [ion binding]; other site 861360003259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360003260 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 861360003261 acyl-activating enzyme (AAE) consensus motif; other site 861360003262 AMP binding site [chemical binding]; other site 861360003263 active site 861360003264 CoA binding site [chemical binding]; other site 861360003265 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 861360003266 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 861360003267 putative trimer interface [polypeptide binding]; other site 861360003268 putative CoA binding site [chemical binding]; other site 861360003269 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 861360003270 putative trimer interface [polypeptide binding]; other site 861360003271 putative CoA binding site [chemical binding]; other site 861360003272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 861360003273 active site 861360003274 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 861360003275 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 861360003276 NADP binding site [chemical binding]; other site 861360003277 dimer interface [polypeptide binding]; other site 861360003278 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 861360003279 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 861360003280 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 861360003281 heterotetramer interface [polypeptide binding]; other site 861360003282 active site pocket [active] 861360003283 cleavage site 861360003284 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 861360003285 homohexameric interface [polypeptide binding]; other site 861360003286 feedback inhibition sensing region; other site 861360003287 nucleotide binding site [chemical binding]; other site 861360003288 N-acetyl-L-glutamate binding site [chemical binding]; other site 861360003289 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 861360003290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360003291 inhibitor-cofactor binding pocket; inhibition site 861360003292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360003293 catalytic residue [active] 861360003294 ornithine carbamoyltransferase; Provisional; Region: PRK00779 861360003295 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 861360003296 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 861360003297 arginine repressor; Provisional; Region: PRK03341 861360003298 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 861360003299 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 861360003300 Domain of unknown function (DUF222); Region: DUF222; pfam02720 861360003301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360003302 active site 861360003303 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 861360003304 ADP-ribose binding site [chemical binding]; other site 861360003305 argininosuccinate lyase; Provisional; Region: PRK00855 861360003306 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 861360003307 active sites [active] 861360003308 tetramer interface [polypeptide binding]; other site 861360003309 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 861360003310 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360003311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360003312 active site 861360003313 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 861360003314 Part of AAA domain; Region: AAA_19; pfam13245 861360003315 Family description; Region: UvrD_C_2; pfam13538 861360003316 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 861360003317 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 861360003318 active site 861360003319 HIGH motif; other site 861360003320 dimer interface [polypeptide binding]; other site 861360003321 KMSKS motif; other site 861360003322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360003323 RNA binding surface [nucleotide binding]; other site 861360003324 MULE transposase domain; Region: MULE; pfam10551 861360003325 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 861360003326 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 861360003327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360003328 active site 861360003329 motif I; other site 861360003330 motif II; other site 861360003331 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 861360003332 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 861360003333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360003334 RNA binding surface [nucleotide binding]; other site 861360003335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360003336 S-adenosylmethionine binding site [chemical binding]; other site 861360003337 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 861360003338 ATP-NAD kinase; Region: NAD_kinase; pfam01513 861360003339 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 861360003340 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 861360003341 Walker A/P-loop; other site 861360003342 ATP binding site [chemical binding]; other site 861360003343 Q-loop/lid; other site 861360003344 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 861360003345 ABC transporter signature motif; other site 861360003346 Walker B; other site 861360003347 D-loop; other site 861360003348 H-loop/switch region; other site 861360003349 CTP synthetase; Validated; Region: pyrG; PRK05380 861360003350 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 861360003351 Catalytic site [active] 861360003352 active site 861360003353 UTP binding site [chemical binding]; other site 861360003354 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 861360003355 active site 861360003356 putative oxyanion hole; other site 861360003357 catalytic triad [active] 861360003358 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 861360003359 dimer interface [polypeptide binding]; other site 861360003360 ADP-ribose binding site [chemical binding]; other site 861360003361 active site 861360003362 nudix motif; other site 861360003363 metal binding site [ion binding]; metal-binding site 861360003364 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 861360003365 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 861360003366 active site 861360003367 Int/Topo IB signature motif; other site 861360003368 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 861360003369 nudix motif; other site 861360003370 Predicted transcriptional regulator [Transcription]; Region: COG3655 861360003371 salt bridge; other site 861360003372 non-specific DNA binding site [nucleotide binding]; other site 861360003373 sequence-specific DNA binding site [nucleotide binding]; other site 861360003374 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 861360003375 citrate synthase; Provisional; Region: PRK14033 861360003376 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 861360003377 oxalacetate binding site [chemical binding]; other site 861360003378 citrylCoA binding site [chemical binding]; other site 861360003379 coenzyme A binding site [chemical binding]; other site 861360003380 catalytic triad [active] 861360003381 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 861360003382 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 861360003383 tetramer interface [polypeptide binding]; other site 861360003384 active site 861360003385 Mg2+/Mn2+ binding site [ion binding]; other site 861360003386 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 861360003387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360003388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360003389 DNA-binding site [nucleotide binding]; DNA binding site 861360003390 FCD domain; Region: FCD; pfam07729 861360003391 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 861360003392 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360003393 acyl-activating enzyme (AAE) consensus motif; other site 861360003394 AMP binding site [chemical binding]; other site 861360003395 active site 861360003396 CoA binding site [chemical binding]; other site 861360003397 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 861360003398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360003399 active site 861360003400 phosphorylation site [posttranslational modification] 861360003401 intermolecular recognition site; other site 861360003402 dimerization interface [polypeptide binding]; other site 861360003403 sensory histidine kinase DcuS; Provisional; Region: PRK11086 861360003404 PAS domain; Region: PAS; smart00091 861360003405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360003406 ATP binding site [chemical binding]; other site 861360003407 Mg2+ binding site [ion binding]; other site 861360003408 G-X-G motif; other site 861360003409 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 861360003410 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 861360003411 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 861360003412 active site 861360003413 catalytic triad [active] 861360003414 oxyanion hole [active] 861360003415 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360003416 active site 861360003417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360003418 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 861360003419 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360003420 P-loop; other site 861360003421 Magnesium ion binding site [ion binding]; other site 861360003422 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360003423 Magnesium ion binding site [ion binding]; other site 861360003424 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 861360003425 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 861360003426 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 861360003427 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360003428 RNA binding surface [nucleotide binding]; other site 861360003429 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 861360003430 active site 861360003431 prephenate dehydrogenase; Validated; Region: PRK06545 861360003432 prephenate dehydrogenase; Validated; Region: PRK08507 861360003433 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 861360003434 cytidylate kinase; Provisional; Region: cmk; PRK00023 861360003435 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 861360003436 CMP-binding site; other site 861360003437 The sites determining sugar specificity; other site 861360003438 GTP-binding protein Der; Reviewed; Region: PRK03003 861360003439 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 861360003440 G1 box; other site 861360003441 GTP/Mg2+ binding site [chemical binding]; other site 861360003442 Switch I region; other site 861360003443 G2 box; other site 861360003444 Switch II region; other site 861360003445 G3 box; other site 861360003446 G4 box; other site 861360003447 G5 box; other site 861360003448 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 861360003449 G1 box; other site 861360003450 GTP/Mg2+ binding site [chemical binding]; other site 861360003451 Switch I region; other site 861360003452 G2 box; other site 861360003453 G3 box; other site 861360003454 Switch II region; other site 861360003455 G4 box; other site 861360003456 G5 box; other site 861360003457 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 861360003458 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360003459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003460 Walker A/P-loop; other site 861360003461 ATP binding site [chemical binding]; other site 861360003462 Q-loop/lid; other site 861360003463 ABC transporter signature motif; other site 861360003464 Walker B; other site 861360003465 D-loop; other site 861360003466 H-loop/switch region; other site 861360003467 ABC transporter; Region: ABC_tran_2; pfam12848 861360003468 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360003469 phenol 2-monooxygenase; Provisional; Region: PRK08294 861360003470 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 861360003471 dimer interface [polypeptide binding]; other site 861360003472 Protein of unknown function, DUF488; Region: DUF488; cl01246 861360003473 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 861360003474 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 861360003475 phosphopeptide binding site; other site 861360003476 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 861360003477 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 861360003478 DNA binding residues [nucleotide binding] 861360003479 Bifunctional nuclease; Region: DNase-RNase; pfam02577 861360003480 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 861360003481 DNA binding residues [nucleotide binding] 861360003482 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 861360003483 putative dimer interface [polypeptide binding]; other site 861360003484 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 861360003485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360003486 P-loop; other site 861360003487 Magnesium ion binding site [ion binding]; other site 861360003488 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360003489 Magnesium ion binding site [ion binding]; other site 861360003490 pyruvate carboxylase; Reviewed; Region: PRK12999 861360003491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360003492 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360003493 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 861360003494 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 861360003495 active site 861360003496 catalytic residues [active] 861360003497 metal binding site [ion binding]; metal-binding site 861360003498 homodimer binding site [polypeptide binding]; other site 861360003499 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 861360003500 carboxyltransferase (CT) interaction site; other site 861360003501 biotinylation site [posttranslational modification]; other site 861360003502 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 861360003503 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 861360003504 acyl-activating enzyme (AAE) consensus motif; other site 861360003505 putative AMP binding site [chemical binding]; other site 861360003506 putative active site [active] 861360003507 putative CoA binding site [chemical binding]; other site 861360003508 Esterase/lipase [General function prediction only]; Region: COG1647 861360003509 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 861360003510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 861360003511 putative acyl-acceptor binding pocket; other site 861360003512 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 861360003513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 861360003514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 861360003515 active site 861360003516 ATP binding site [chemical binding]; other site 861360003517 substrate binding site [chemical binding]; other site 861360003518 activation loop (A-loop); other site 861360003519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 861360003520 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360003521 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360003522 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360003523 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 861360003524 Transcription factor WhiB; Region: Whib; pfam02467 861360003525 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 861360003526 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 861360003527 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 861360003528 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 861360003529 ATP binding site [chemical binding]; other site 861360003530 Walker A motif; other site 861360003531 hexamer interface [polypeptide binding]; other site 861360003532 Walker B motif; other site 861360003533 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 861360003534 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 861360003535 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 861360003536 TadE-like protein; Region: TadE; pfam07811 861360003537 peptide chain release factor 2; Validated; Region: prfB; PRK00578 861360003538 This domain is found in peptide chain release factors; Region: PCRF; smart00937 861360003539 RF-1 domain; Region: RF-1; pfam00472 861360003540 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 861360003541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003542 Walker A/P-loop; other site 861360003543 ATP binding site [chemical binding]; other site 861360003544 Q-loop/lid; other site 861360003545 ABC transporter signature motif; other site 861360003546 Walker B; other site 861360003547 D-loop; other site 861360003548 H-loop/switch region; other site 861360003549 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 861360003550 FtsX-like permease family; Region: FtsX; pfam02687 861360003551 Prefoldin subunit; Region: Prefoldin_2; pfam01920 861360003552 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 861360003553 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360003554 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360003555 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 861360003556 SmpB-tmRNA interface; other site 861360003557 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 861360003558 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 861360003559 active site 861360003560 DNA binding site [nucleotide binding] 861360003561 Int/Topo IB signature motif; other site 861360003562 CrcB-like protein; Region: CRCB; cl09114 861360003563 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 861360003564 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 861360003565 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 861360003566 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 861360003567 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 861360003568 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 861360003569 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 861360003570 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 861360003571 active site 861360003572 Predicted GTPases [General function prediction only]; Region: COG1162 861360003573 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 861360003574 GTPase/Zn-binding domain interface [polypeptide binding]; other site 861360003575 GTP/Mg2+ binding site [chemical binding]; other site 861360003576 G4 box; other site 861360003577 G5 box; other site 861360003578 G1 box; other site 861360003579 Switch I region; other site 861360003580 G2 box; other site 861360003581 G3 box; other site 861360003582 Switch II region; other site 861360003583 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 861360003584 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 861360003585 hinge; other site 861360003586 active site 861360003587 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 861360003588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360003589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360003590 DNA binding residues [nucleotide binding] 861360003591 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 861360003592 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 861360003593 active site 861360003594 catalytic triad [active] 861360003595 oxyanion hole [active] 861360003596 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 861360003597 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 861360003598 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 861360003599 TPP-binding site [chemical binding]; other site 861360003600 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 861360003601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 861360003602 Domain of unknown function DUF21; Region: DUF21; pfam01595 861360003603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 861360003604 Transporter associated domain; Region: CorC_HlyC; smart01091 861360003605 Domain of unknown function DUF21; Region: DUF21; pfam01595 861360003606 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 861360003607 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 861360003608 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 861360003609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003610 Walker A/P-loop; other site 861360003611 ATP binding site [chemical binding]; other site 861360003612 Q-loop/lid; other site 861360003613 ABC transporter signature motif; other site 861360003614 Walker B; other site 861360003615 D-loop; other site 861360003616 H-loop/switch region; other site 861360003617 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 861360003618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 861360003619 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 861360003620 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360003621 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 861360003622 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 861360003623 metal binding site 2 [ion binding]; metal-binding site 861360003624 putative DNA binding helix; other site 861360003625 metal binding site 1 [ion binding]; metal-binding site 861360003626 dimer interface [polypeptide binding]; other site 861360003627 structural Zn2+ binding site [ion binding]; other site 861360003628 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 861360003629 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 861360003630 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 861360003631 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 861360003632 active site residue [active] 861360003633 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 861360003634 active site residue [active] 861360003635 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 861360003636 nucleotide binding site/active site [active] 861360003637 HIT family signature motif; other site 861360003638 catalytic residue [active] 861360003639 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 861360003640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360003641 ATP binding site [chemical binding]; other site 861360003642 putative Mg++ binding site [ion binding]; other site 861360003643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360003644 nucleotide binding region [chemical binding]; other site 861360003645 ATP-binding site [chemical binding]; other site 861360003646 Helicase associated domain (HA2); Region: HA2; pfam04408 861360003647 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 861360003648 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 861360003649 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 861360003650 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 861360003651 zinc binding site [ion binding]; other site 861360003652 putative ligand binding site [chemical binding]; other site 861360003653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 861360003654 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 861360003655 TM-ABC transporter signature motif; other site 861360003656 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 861360003657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003658 Walker A/P-loop; other site 861360003659 ATP binding site [chemical binding]; other site 861360003660 Q-loop/lid; other site 861360003661 ABC transporter signature motif; other site 861360003662 Walker B; other site 861360003663 D-loop; other site 861360003664 H-loop/switch region; other site 861360003665 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360003666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003667 putative substrate translocation pore; other site 861360003668 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360003669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360003670 Coenzyme A binding pocket [chemical binding]; other site 861360003671 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 861360003672 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 861360003673 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 861360003674 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 861360003675 active site 861360003676 HIGH motif; other site 861360003677 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360003678 KMSK motif region; other site 861360003679 tRNA binding surface [nucleotide binding]; other site 861360003680 DALR anticodon binding domain; Region: DALR_1; smart00836 861360003681 anticodon binding site; other site 861360003682 diaminopimelate decarboxylase; Region: lysA; TIGR01048 861360003683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 861360003684 active site 861360003685 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360003686 substrate binding site [chemical binding]; other site 861360003687 catalytic residues [active] 861360003688 dimer interface [polypeptide binding]; other site 861360003689 homoserine dehydrogenase; Provisional; Region: PRK06349 861360003690 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 861360003691 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 861360003692 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 861360003693 threonine synthase; Reviewed; Region: PRK06721 861360003694 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 861360003695 homodimer interface [polypeptide binding]; other site 861360003696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360003697 catalytic residue [active] 861360003698 homoserine kinase; Provisional; Region: PRK01212 861360003699 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 861360003700 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 861360003701 transcription termination factor Rho; Provisional; Region: rho; PRK09376 861360003702 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 861360003703 RNA binding site [nucleotide binding]; other site 861360003704 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 861360003705 multimer interface [polypeptide binding]; other site 861360003706 Walker A motif; other site 861360003707 ATP binding site [chemical binding]; other site 861360003708 Walker B motif; other site 861360003709 peptide chain release factor 1; Validated; Region: prfA; PRK00591 861360003710 This domain is found in peptide chain release factors; Region: PCRF; smart00937 861360003711 RF-1 domain; Region: RF-1; pfam00472 861360003712 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 861360003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360003714 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 861360003715 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 861360003716 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 861360003717 Mg++ binding site [ion binding]; other site 861360003718 putative catalytic motif [active] 861360003719 substrate binding site [chemical binding]; other site 861360003720 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 861360003721 ATP synthase subunit C; Region: ATP-synt_C; cl00466 861360003722 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 861360003723 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 861360003724 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 861360003725 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 861360003726 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 861360003727 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 861360003728 beta subunit interaction interface [polypeptide binding]; other site 861360003729 Walker A motif; other site 861360003730 ATP binding site [chemical binding]; other site 861360003731 Walker B motif; other site 861360003732 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 861360003733 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 861360003734 core domain interface [polypeptide binding]; other site 861360003735 delta subunit interface [polypeptide binding]; other site 861360003736 epsilon subunit interface [polypeptide binding]; other site 861360003737 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 861360003738 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 861360003739 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 861360003740 alpha subunit interaction interface [polypeptide binding]; other site 861360003741 Walker A motif; other site 861360003742 ATP binding site [chemical binding]; other site 861360003743 Walker B motif; other site 861360003744 inhibitor binding site; inhibition site 861360003745 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 861360003746 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 861360003747 gamma subunit interface [polypeptide binding]; other site 861360003748 epsilon subunit interface [polypeptide binding]; other site 861360003749 LBP interface [polypeptide binding]; other site 861360003750 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 861360003751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360003752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 861360003753 NAD(P) binding site [chemical binding]; other site 861360003754 active site 861360003755 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 861360003756 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 861360003757 active site 861360003758 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 861360003759 hypothetical protein; Provisional; Region: PRK03298 861360003760 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 861360003761 Domain of unknown function DUF20; Region: UPF0118; pfam01594 861360003762 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 861360003763 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 861360003764 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 861360003765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 861360003766 Walker A/P-loop; other site 861360003767 ATP binding site [chemical binding]; other site 861360003768 Q-loop/lid; other site 861360003769 ABC transporter signature motif; other site 861360003770 Walker B; other site 861360003771 D-loop; other site 861360003772 H-loop/switch region; other site 861360003773 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 861360003774 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 861360003775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360003776 ATP binding site [chemical binding]; other site 861360003777 putative Mg++ binding site [ion binding]; other site 861360003778 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 861360003779 Isochorismatase family; Region: Isochorismatase; pfam00857 861360003780 catalytic triad [active] 861360003781 conserved cis-peptide bond; other site 861360003782 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 861360003783 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 861360003784 active site 861360003785 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 861360003786 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 861360003787 glutamate racemase; Provisional; Region: PRK00865 861360003788 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 861360003789 ribonuclease PH; Reviewed; Region: rph; PRK00173 861360003790 Ribonuclease PH; Region: RNase_PH_bact; cd11362 861360003791 hexamer interface [polypeptide binding]; other site 861360003792 active site 861360003793 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 861360003794 active site 861360003795 dimerization interface [polypeptide binding]; other site 861360003796 Predicted transcriptional regulators [Transcription]; Region: COG1725 861360003797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360003798 DNA-binding site [nucleotide binding]; DNA binding site 861360003799 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 861360003800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 861360003801 Walker A/P-loop; other site 861360003802 ATP binding site [chemical binding]; other site 861360003803 Q-loop/lid; other site 861360003804 ABC transporter signature motif; other site 861360003805 Walker B; other site 861360003806 D-loop; other site 861360003807 H-loop/switch region; other site 861360003808 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 861360003809 hydrophobic ligand binding site; other site 861360003810 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 861360003811 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 861360003812 active site 861360003813 catalytic site [active] 861360003814 substrate binding site [chemical binding]; other site 861360003815 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 861360003816 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 861360003817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 861360003818 active site 861360003819 metal binding site [ion binding]; metal-binding site 861360003820 DNA binding site [nucleotide binding] 861360003821 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 861360003822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003823 AAA domain; Region: AAA_23; pfam13476 861360003824 Walker A/P-loop; other site 861360003825 ATP binding site [chemical binding]; other site 861360003826 Q-loop/lid; other site 861360003827 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 861360003828 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 861360003829 ABC transporter signature motif; other site 861360003830 Walker B; other site 861360003831 D-loop; other site 861360003832 H-loop/switch region; other site 861360003833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360003834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003835 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360003836 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 861360003837 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360003838 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360003839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003840 putative substrate translocation pore; other site 861360003841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360003842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360003843 DNA binding site [nucleotide binding] 861360003844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 861360003845 dimerization interface [polypeptide binding]; other site 861360003846 ligand binding site [chemical binding]; other site 861360003847 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 861360003848 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 861360003849 active site 861360003850 catalytic site [active] 861360003851 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 861360003852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 861360003853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360003854 dimer interface [polypeptide binding]; other site 861360003855 conserved gate region; other site 861360003856 ABC-ATPase subunit interface; other site 861360003857 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 861360003858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360003859 dimer interface [polypeptide binding]; other site 861360003860 conserved gate region; other site 861360003861 putative PBP binding loops; other site 861360003862 ABC-ATPase subunit interface; other site 861360003863 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 861360003864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360003865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360003866 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 861360003867 putative transporter; Provisional; Region: PRK10504 861360003868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003869 putative substrate translocation pore; other site 861360003870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360003871 META domain; Region: META; cl01245 861360003872 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 861360003873 Fatty acid desaturase; Region: FA_desaturase; pfam00487 861360003874 putative di-iron ligands [ion binding]; other site 861360003875 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360003876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360003877 Walker A/P-loop; other site 861360003878 ATP binding site [chemical binding]; other site 861360003879 Q-loop/lid; other site 861360003880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360003881 ABC transporter; Region: ABC_tran_2; pfam12848 861360003882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360003883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360003884 putative DNA binding site [nucleotide binding]; other site 861360003885 dimerization interface [polypeptide binding]; other site 861360003886 putative Zn2+ binding site [ion binding]; other site 861360003887 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360003888 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360003889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360003890 active site 861360003891 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 861360003892 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 861360003893 tetramer interface [polypeptide binding]; other site 861360003894 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 861360003895 tetramer interface [polypeptide binding]; other site 861360003896 active site 861360003897 metal binding site [ion binding]; metal-binding site 861360003898 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 861360003899 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 861360003900 NAD binding site [chemical binding]; other site 861360003901 catalytic residues [active] 861360003902 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360003903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360003904 DNA-binding site [nucleotide binding]; DNA binding site 861360003905 FCD domain; Region: FCD; pfam07729 861360003906 hypothetical protein; Provisional; Region: PRK12764 861360003907 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 861360003908 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 861360003909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 861360003910 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 861360003911 FtsX-like permease family; Region: FtsX; pfam02687 861360003912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360003913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 861360003914 Walker A/P-loop; other site 861360003915 ATP binding site [chemical binding]; other site 861360003916 Q-loop/lid; other site 861360003917 ABC transporter signature motif; other site 861360003918 Walker B; other site 861360003919 D-loop; other site 861360003920 H-loop/switch region; other site 861360003921 HlyD family secretion protein; Region: HlyD_3; pfam13437 861360003922 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 861360003923 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360003924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360003925 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360003926 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360003927 Helix-turn-helix domain; Region: HTH_28; pfam13518 861360003928 Winged helix-turn helix; Region: HTH_29; pfam13551 861360003929 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 861360003930 Integrase core domain; Region: rve; pfam00665 861360003931 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 861360003932 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360003933 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 861360003934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360003935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360003936 sequence-specific DNA binding site [nucleotide binding]; other site 861360003937 salt bridge; other site 861360003938 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 861360003939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360003940 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 861360003941 nudix motif; other site 861360003942 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 861360003943 quinolinate synthetase; Provisional; Region: PRK09375 861360003944 L-aspartate oxidase; Provisional; Region: PRK06175 861360003945 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 861360003946 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 861360003947 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 861360003948 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 861360003949 dimerization interface [polypeptide binding]; other site 861360003950 active site 861360003951 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 861360003952 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 861360003953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360003954 catalytic residue [active] 861360003955 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003956 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003957 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003958 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003959 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 861360003960 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 861360003961 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003962 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003963 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360003964 Predicted acetyltransferase [General function prediction only]; Region: COG3153 861360003965 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 861360003966 hydrophobic ligand binding site; other site 861360003967 RibD C-terminal domain; Region: RibD_C; cl17279 861360003968 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 861360003969 GIY-YIG motif/motif A; other site 861360003970 active site 861360003971 catalytic site [active] 861360003972 metal binding site [ion binding]; metal-binding site 861360003973 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360003974 MarR family; Region: MarR_2; pfam12802 861360003975 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 861360003976 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 861360003977 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 861360003978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360003979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360003980 active site 861360003981 phosphorylation site [posttranslational modification] 861360003982 intermolecular recognition site; other site 861360003983 dimerization interface [polypeptide binding]; other site 861360003984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360003985 DNA binding residues [nucleotide binding] 861360003986 dimerization interface [polypeptide binding]; other site 861360003987 Uncharacterized conserved protein [Function unknown]; Region: COG0398 861360003988 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 861360003989 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 861360003990 Protein export membrane protein; Region: SecD_SecF; cl14618 861360003991 Helix-turn-helix domain; Region: HTH_28; pfam13518 861360003992 Winged helix-turn helix; Region: HTH_29; pfam13551 861360003993 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 861360003994 Integrase core domain; Region: rve; pfam00665 861360003995 malate:quinone oxidoreductase; Validated; Region: PRK05257 861360003996 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 861360003997 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 861360003998 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360003999 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360004000 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 861360004001 glyoxylate reductase; Reviewed; Region: PRK13243 861360004002 putative ligand binding site [chemical binding]; other site 861360004003 putative NAD binding site [chemical binding]; other site 861360004004 catalytic site [active] 861360004005 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 861360004006 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 861360004007 catalytic triad [active] 861360004008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360004009 MarR family; Region: MarR; pfam01047 861360004010 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 861360004011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360004012 NAD(P) binding site [chemical binding]; other site 861360004013 active site 861360004014 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 861360004015 MarR family; Region: MarR; pfam01047 861360004016 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 861360004017 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 861360004018 substrate binding pocket [chemical binding]; other site 861360004019 chain length determination region; other site 861360004020 substrate-Mg2+ binding site; other site 861360004021 catalytic residues [active] 861360004022 aspartate-rich region 1; other site 861360004023 active site lid residues [active] 861360004024 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 861360004025 aspartate-rich region 2; other site 861360004026 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 861360004027 substrate binding pocket [chemical binding]; other site 861360004028 substrate-Mg2+ binding site; other site 861360004029 aspartate-rich region 1; other site 861360004030 aspartate-rich region 2; other site 861360004031 phytoene desaturase; Region: crtI_fam; TIGR02734 861360004032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360004033 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 861360004034 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 861360004035 prenyltransferase; Reviewed; Region: ubiA; PRK13105 861360004036 UbiA prenyltransferase family; Region: UbiA; pfam01040 861360004037 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 861360004038 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 861360004039 active site 861360004040 metal binding site [ion binding]; metal-binding site 861360004041 nudix motif; other site 861360004042 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 861360004043 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 861360004044 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 861360004045 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 861360004046 PYR/PP interface [polypeptide binding]; other site 861360004047 dimer interface [polypeptide binding]; other site 861360004048 TPP binding site [chemical binding]; other site 861360004049 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360004050 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 861360004051 TPP-binding site [chemical binding]; other site 861360004052 dimer interface [polypeptide binding]; other site 861360004053 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 861360004054 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 861360004055 putative valine binding site [chemical binding]; other site 861360004056 dimer interface [polypeptide binding]; other site 861360004057 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 861360004058 ketol-acid reductoisomerase; Provisional; Region: PRK05479 861360004059 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 861360004060 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 861360004061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004062 S-adenosylmethionine binding site [chemical binding]; other site 861360004063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360004064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360004065 DNA binding residues [nucleotide binding] 861360004066 dimerization interface [polypeptide binding]; other site 861360004067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360004068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360004069 DNA binding residues [nucleotide binding] 861360004070 dimerization interface [polypeptide binding]; other site 861360004071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360004072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004073 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360004075 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004076 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 861360004077 Bacterial sugar transferase; Region: Bac_transf; pfam02397 861360004078 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 861360004079 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 861360004080 putative acyl transferase; Provisional; Region: PRK10191 861360004081 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 861360004082 trimer interface [polypeptide binding]; other site 861360004083 active site 861360004084 substrate binding site [chemical binding]; other site 861360004085 CoA binding site [chemical binding]; other site 861360004086 Chain length determinant protein; Region: Wzz; pfam02706 861360004087 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 861360004088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 861360004089 active site 861360004090 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 861360004091 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 861360004092 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 861360004093 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 861360004094 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 861360004095 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 861360004096 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 861360004097 FOG: PKD repeat [General function prediction only]; Region: COG3291 861360004098 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 861360004099 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 861360004100 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 861360004101 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 861360004102 TrkA-C domain; Region: TrkA_C; pfam02080 861360004103 TrkA-C domain; Region: TrkA_C; pfam02080 861360004104 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 861360004105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360004106 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004107 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 861360004108 ligand-binding site [chemical binding]; other site 861360004109 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 861360004110 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 861360004111 active site 861360004112 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 861360004113 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 861360004114 Active Sites [active] 861360004115 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 861360004116 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 861360004117 CysD dimerization site [polypeptide binding]; other site 861360004118 G1 box; other site 861360004119 putative GEF interaction site [polypeptide binding]; other site 861360004120 GTP/Mg2+ binding site [chemical binding]; other site 861360004121 Switch I region; other site 861360004122 G2 box; other site 861360004123 G3 box; other site 861360004124 Switch II region; other site 861360004125 G4 box; other site 861360004126 G5 box; other site 861360004127 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 861360004128 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 861360004129 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 861360004130 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 861360004131 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 861360004132 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 861360004133 ligand binding site [chemical binding]; other site 861360004134 NAD binding site [chemical binding]; other site 861360004135 dimerization interface [polypeptide binding]; other site 861360004136 catalytic site [active] 861360004137 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 861360004138 putative L-serine binding site [chemical binding]; other site 861360004139 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 861360004140 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 861360004141 Winged helix-turn helix; Region: HTH_29; pfam13551 861360004142 Integrase core domain; Region: rve; pfam00665 861360004143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360004144 Integrase core domain; Region: rve_3; pfam13683 861360004145 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004146 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004147 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 861360004148 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 861360004149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360004150 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 861360004151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 861360004152 active site 861360004153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 861360004154 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 861360004155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 861360004156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 861360004157 active site 861360004158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 861360004159 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360004160 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 861360004161 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 861360004162 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 861360004163 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 861360004164 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 861360004165 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 861360004166 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 861360004167 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 861360004168 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 861360004169 active site 861360004170 homodimer interface [polypeptide binding]; other site 861360004171 LabA_like proteins; Region: LabA_like; cd06167 861360004172 putative metal binding site [ion binding]; other site 861360004173 Uncharacterized conserved protein [Function unknown]; Region: COG1432 861360004174 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 861360004175 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 861360004176 active site 861360004177 HIGH motif; other site 861360004178 KMSKS motif; other site 861360004179 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 861360004180 tRNA binding surface [nucleotide binding]; other site 861360004181 anticodon binding site; other site 861360004182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360004183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360004184 active site 861360004185 phosphorylation site [posttranslational modification] 861360004186 intermolecular recognition site; other site 861360004187 dimerization interface [polypeptide binding]; other site 861360004188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360004189 DNA binding residues [nucleotide binding] 861360004190 dimerization interface [polypeptide binding]; other site 861360004191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 861360004192 Histidine kinase; Region: HisKA_3; pfam07730 861360004193 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 861360004194 ATP binding site [chemical binding]; other site 861360004195 Mg2+ binding site [ion binding]; other site 861360004196 G-X-G motif; other site 861360004197 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 861360004198 tartrate dehydrogenase; Region: TTC; TIGR02089 861360004199 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 861360004200 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 861360004201 homodimer interface [polypeptide binding]; other site 861360004202 substrate-cofactor binding pocket; other site 861360004203 catalytic residue [active] 861360004204 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 861360004205 UDP-glucose 4-epimerase; Region: PLN02240 861360004206 NAD binding site [chemical binding]; other site 861360004207 homodimer interface [polypeptide binding]; other site 861360004208 active site 861360004209 substrate binding site [chemical binding]; other site 861360004210 FOG: WD40 repeat [General function prediction only]; Region: COG2319 861360004211 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004212 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004213 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360004215 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004216 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 861360004217 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 861360004218 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 861360004219 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 861360004220 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 861360004221 HIGH motif; other site 861360004222 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 861360004223 active site 861360004224 KMSKS motif; other site 861360004225 Dynamin family; Region: Dynamin_N; pfam00350 861360004226 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 861360004227 G3 box; other site 861360004228 Switch II region; other site 861360004229 G4 box; other site 861360004230 YfjP GTPase; Region: YfjP; cd11383 861360004231 G1 box; other site 861360004232 GTP/Mg2+ binding site [chemical binding]; other site 861360004233 Switch I region; other site 861360004234 G2 box; other site 861360004235 Switch II region; other site 861360004236 G3 box; other site 861360004237 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 861360004238 G4 box; other site 861360004239 G4 box; other site 861360004240 G5 box; other site 861360004241 thiamine monophosphate kinase; Provisional; Region: PRK05731 861360004242 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 861360004243 ATP binding site [chemical binding]; other site 861360004244 dimerization interface [polypeptide binding]; other site 861360004245 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360004246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360004247 putative DNA binding site [nucleotide binding]; other site 861360004248 putative Zn2+ binding site [ion binding]; other site 861360004249 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360004250 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 861360004251 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 861360004252 substrate binding site [chemical binding]; other site 861360004253 ligand binding site [chemical binding]; other site 861360004254 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 861360004255 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 861360004256 substrate binding site [chemical binding]; other site 861360004257 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 861360004258 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 861360004259 hinge; other site 861360004260 active site 861360004261 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 861360004262 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 861360004263 putative acyl-acceptor binding pocket; other site 861360004264 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 861360004265 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 861360004266 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 861360004267 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 861360004268 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 861360004269 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 861360004270 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 861360004271 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 861360004272 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 861360004273 DAK2 domain; Region: Dak2; pfam02734 861360004274 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 861360004275 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 861360004276 ssDNA binding site; other site 861360004277 generic binding surface II; other site 861360004278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360004279 ATP binding site [chemical binding]; other site 861360004280 putative Mg++ binding site [ion binding]; other site 861360004281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360004282 nucleotide binding region [chemical binding]; other site 861360004283 ATP-binding site [chemical binding]; other site 861360004284 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 861360004285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004286 S-adenosylmethionine binding site [chemical binding]; other site 861360004287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004288 S-adenosylmethionine binding site [chemical binding]; other site 861360004289 aminotransferase; Validated; Region: PRK07777 861360004290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360004291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360004292 homodimer interface [polypeptide binding]; other site 861360004293 catalytic residue [active] 861360004294 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 861360004295 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 861360004296 active site 861360004297 (T/H)XGH motif; other site 861360004298 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 861360004299 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 861360004300 active site 861360004301 tetramer interface; other site 861360004302 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 861360004303 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 861360004304 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 861360004305 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 861360004306 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 861360004307 Walker A/P-loop; other site 861360004308 ATP binding site [chemical binding]; other site 861360004309 Q-loop/lid; other site 861360004310 ABC transporter signature motif; other site 861360004311 Walker B; other site 861360004312 D-loop; other site 861360004313 H-loop/switch region; other site 861360004314 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 861360004315 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 861360004316 Ligand binding site; other site 861360004317 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 861360004318 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 861360004319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 861360004320 active site 861360004321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360004322 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 861360004323 active site 861360004324 nucleotide binding site [chemical binding]; other site 861360004325 HIGH motif; other site 861360004326 KMSKS motif; other site 861360004327 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 861360004328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360004329 Integrase core domain; Region: rve; pfam00665 861360004330 Integrase core domain; Region: rve_3; pfam13683 861360004331 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 861360004332 Integrase core domain; Region: rve; pfam00665 861360004333 Integrase core domain; Region: rve_3; pfam13683 861360004334 Transposase; Region: HTH_Tnp_1; cl17663 861360004335 Transposase; Region: HTH_Tnp_1; pfam01527 861360004336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360004337 Integrase core domain; Region: rve; pfam00665 861360004338 Integrase core domain; Region: rve_3; pfam13683 861360004339 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 861360004340 Transposase; Region: HTH_Tnp_1; cl17663 861360004341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360004342 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 861360004343 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 861360004344 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 861360004345 ribonuclease III; Reviewed; Region: rnc; PRK00102 861360004346 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 861360004347 dimerization interface [polypeptide binding]; other site 861360004348 active site 861360004349 metal binding site [ion binding]; metal-binding site 861360004350 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 861360004351 dsRNA binding site [nucleotide binding]; other site 861360004352 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 861360004353 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 861360004354 DNA binding site [nucleotide binding] 861360004355 catalytic residue [active] 861360004356 H2TH interface [polypeptide binding]; other site 861360004357 putative catalytic residues [active] 861360004358 turnover-facilitating residue; other site 861360004359 intercalation triad [nucleotide binding]; other site 861360004360 8OG recognition residue [nucleotide binding]; other site 861360004361 putative reading head residues; other site 861360004362 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 861360004363 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 861360004364 Beta-lactamase; Region: Beta-lactamase; pfam00144 861360004365 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 861360004366 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 861360004367 Walker A/P-loop; other site 861360004368 ATP binding site [chemical binding]; other site 861360004369 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 861360004370 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 861360004371 ABC transporter signature motif; other site 861360004372 Walker B; other site 861360004373 D-loop; other site 861360004374 H-loop/switch region; other site 861360004375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360004376 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 861360004377 putative substrate translocation pore; other site 861360004378 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 861360004379 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 861360004380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 861360004381 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 861360004382 active site 861360004383 DNA binding site [nucleotide binding] 861360004384 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 861360004385 hydroperoxidase II; Provisional; Region: katE; PRK11249 861360004386 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 861360004387 heme binding pocket [chemical binding]; other site 861360004388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 861360004389 conserved cys residue [active] 861360004390 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 861360004391 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 861360004392 CsbD-like; Region: CsbD; pfam05532 861360004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360004394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360004395 putative substrate translocation pore; other site 861360004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360004397 putative substrate translocation pore; other site 861360004398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360004399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360004400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360004401 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 861360004402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004403 S-adenosylmethionine binding site [chemical binding]; other site 861360004404 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 861360004405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 861360004406 active site 861360004407 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 861360004408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360004409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360004410 signal recognition particle protein; Provisional; Region: PRK10867 861360004411 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 861360004412 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 861360004413 P loop; other site 861360004414 GTP binding site [chemical binding]; other site 861360004415 Signal peptide binding domain; Region: SRP_SPB; pfam02978 861360004416 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360004417 MarR family; Region: MarR_2; pfam12802 861360004418 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 861360004419 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360004420 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360004422 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 861360004424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360004425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360004426 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004427 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004428 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004429 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 861360004430 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360004431 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 861360004432 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360004433 acyl-activating enzyme (AAE) consensus motif; other site 861360004434 AMP binding site [chemical binding]; other site 861360004435 active site 861360004436 CoA binding site [chemical binding]; other site 861360004437 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 861360004438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360004439 acyl-activating enzyme (AAE) consensus motif; other site 861360004440 AMP binding site [chemical binding]; other site 861360004441 active site 861360004442 CoA binding site [chemical binding]; other site 861360004443 Staphylococcal nuclease homologues; Region: SNc; smart00318 861360004444 Catalytic site; other site 861360004445 Staphylococcal nuclease homologue; Region: SNase; pfam00565 861360004446 Staphylococcal nuclease homologues; Region: SNc; smart00318 861360004447 Catalytic site; other site 861360004448 Staphylococcal nuclease homologue; Region: SNase; pfam00565 861360004449 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 861360004450 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 861360004451 putative metal binding site [ion binding]; other site 861360004452 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 861360004453 active site 861360004454 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 861360004455 trimer interface [polypeptide binding]; other site 861360004456 active site 861360004457 substrate binding site [chemical binding]; other site 861360004458 CoA binding site [chemical binding]; other site 861360004459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 861360004460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 861360004461 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360004462 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 861360004463 intersubunit interface [polypeptide binding]; other site 861360004464 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 861360004465 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360004466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360004467 ABC-ATPase subunit interface; other site 861360004468 dimer interface [polypeptide binding]; other site 861360004469 putative PBP binding regions; other site 861360004470 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360004471 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360004472 ABC-ATPase subunit interface; other site 861360004473 dimer interface [polypeptide binding]; other site 861360004474 putative PBP binding regions; other site 861360004475 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360004476 active site 861360004477 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 861360004478 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 861360004479 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 861360004480 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 861360004481 RimM N-terminal domain; Region: RimM; pfam01782 861360004482 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 861360004483 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 861360004484 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 861360004485 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 861360004486 Catalytic site [active] 861360004487 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 861360004488 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 861360004489 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 861360004490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 861360004491 Catalytic site [active] 861360004492 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 861360004493 RNA/DNA hybrid binding site [nucleotide binding]; other site 861360004494 active site 861360004495 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 861360004496 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 861360004497 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 861360004498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360004499 dimer interface [polypeptide binding]; other site 861360004500 conserved gate region; other site 861360004501 ABC-ATPase subunit interface; other site 861360004502 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 861360004503 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 861360004504 Walker A/P-loop; other site 861360004505 ATP binding site [chemical binding]; other site 861360004506 Q-loop/lid; other site 861360004507 ABC transporter signature motif; other site 861360004508 Walker B; other site 861360004509 D-loop; other site 861360004510 H-loop/switch region; other site 861360004511 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 861360004512 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360004513 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360004514 hypothetical protein; Reviewed; Region: PRK12497 861360004515 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 861360004516 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 861360004517 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 861360004518 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 861360004519 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 861360004520 DNA protecting protein DprA; Region: dprA; TIGR00732 861360004521 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 861360004522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 861360004523 active site 861360004524 DNA binding site [nucleotide binding] 861360004525 Int/Topo IB signature motif; other site 861360004526 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 861360004527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 861360004528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360004529 active site 861360004530 metal binding site [ion binding]; metal-binding site 861360004531 RibD C-terminal domain; Region: RibD_C; pfam01872 861360004532 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 861360004533 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 861360004534 dimer interface [polypeptide binding]; other site 861360004535 active site 861360004536 acyl carrier protein; Provisional; Region: acpP; PRK00982 861360004537 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 861360004538 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 861360004539 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 861360004540 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 861360004541 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 861360004542 dimer interface [polypeptide binding]; other site 861360004543 TPP-binding site [chemical binding]; other site 861360004544 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 861360004545 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 861360004546 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 861360004547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004548 S-adenosylmethionine binding site [chemical binding]; other site 861360004549 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360004550 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 861360004551 CsbD-like; Region: CsbD; pfam05532 861360004552 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 861360004553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004554 S-adenosylmethionine binding site [chemical binding]; other site 861360004555 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 861360004556 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 861360004557 homodimer interface [polypeptide binding]; other site 861360004558 active site 861360004559 TDP-binding site; other site 861360004560 acceptor substrate-binding pocket; other site 861360004561 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 861360004562 acetylornithine deacetylase; Provisional; Region: PRK07522 861360004563 metal binding site [ion binding]; metal-binding site 861360004564 putative dimer interface [polypeptide binding]; other site 861360004565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360004566 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360004567 putative substrate translocation pore; other site 861360004568 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 861360004569 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 861360004570 Predicted kinase [General function prediction only]; Region: COG0645 861360004571 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 861360004572 ATP-binding site [chemical binding]; other site 861360004573 Gluconate-6-phosphate binding site [chemical binding]; other site 861360004574 Shikimate kinase; Region: SKI; pfam01202 861360004575 fructuronate transporter; Provisional; Region: PRK10034; cl15264 861360004576 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 861360004577 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 861360004578 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360004579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360004580 DNA-binding site [nucleotide binding]; DNA binding site 861360004581 FCD domain; Region: FCD; pfam07729 861360004582 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 861360004583 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 861360004584 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 861360004585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360004586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360004587 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 861360004588 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 861360004589 Prostaglandin dehydrogenases; Region: PGDH; cd05288 861360004590 NAD(P) binding site [chemical binding]; other site 861360004591 substrate binding site [chemical binding]; other site 861360004592 dimer interface [polypeptide binding]; other site 861360004593 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360004594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360004595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360004596 Walker A/P-loop; other site 861360004597 ATP binding site [chemical binding]; other site 861360004598 Q-loop/lid; other site 861360004599 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 861360004600 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 861360004601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360004602 Walker A/P-loop; other site 861360004603 ATP binding site [chemical binding]; other site 861360004604 Q-loop/lid; other site 861360004605 ABC transporter signature motif; other site 861360004606 Walker B; other site 861360004607 D-loop; other site 861360004608 H-loop/switch region; other site 861360004609 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 861360004610 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 861360004611 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 861360004612 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 861360004613 trimer interface [polypeptide binding]; other site 861360004614 active site 861360004615 substrate binding site [chemical binding]; other site 861360004616 CoA binding site [chemical binding]; other site 861360004617 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 861360004618 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 861360004619 dimer interface [polypeptide binding]; other site 861360004620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360004621 catalytic residue [active] 861360004622 methionine sulfoxide reductase A; Provisional; Region: PRK14054 861360004623 Uncharacterized conserved protein [Function unknown]; Region: COG0327 861360004624 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 861360004625 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 861360004626 putative dimer interface [polypeptide binding]; other site 861360004627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360004628 ligand binding site [chemical binding]; other site 861360004629 Zn binding site [ion binding]; other site 861360004630 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 861360004631 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 861360004632 Interdomain contacts; other site 861360004633 Cytokine receptor motif; other site 861360004634 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 861360004635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 861360004636 active site 861360004637 metal binding site [ion binding]; metal-binding site 861360004638 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360004639 active site 861360004640 metal binding site [ion binding]; metal-binding site 861360004641 Protein of unknown function (DUF328); Region: DUF328; pfam03883 861360004642 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 861360004643 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 861360004644 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 861360004645 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 861360004646 active site 861360004647 catalytic residues [active] 861360004648 metal binding site [ion binding]; metal-binding site 861360004649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360004650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360004651 active site 861360004652 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 861360004653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360004654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360004655 DNA binding residues [nucleotide binding] 861360004656 dimerization interface [polypeptide binding]; other site 861360004657 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 861360004658 catalytic site [active] 861360004659 putative active site [active] 861360004660 putative substrate binding site [chemical binding]; other site 861360004661 dimer interface [polypeptide binding]; other site 861360004662 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 861360004663 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 861360004664 VanZ like family; Region: VanZ; cl01971 861360004665 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 861360004666 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 861360004667 synthetase active site [active] 861360004668 NTP binding site [chemical binding]; other site 861360004669 metal binding site [ion binding]; metal-binding site 861360004670 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360004671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360004672 Walker A/P-loop; other site 861360004673 ATP binding site [chemical binding]; other site 861360004674 Q-loop/lid; other site 861360004675 ABC transporter signature motif; other site 861360004676 Walker B; other site 861360004677 D-loop; other site 861360004678 H-loop/switch region; other site 861360004679 ABC transporter; Region: ABC_tran_2; pfam12848 861360004680 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360004681 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 861360004682 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 861360004683 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 861360004684 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 861360004685 NAD(P) binding site [chemical binding]; other site 861360004686 homotetramer interface [polypeptide binding]; other site 861360004687 homodimer interface [polypeptide binding]; other site 861360004688 active site 861360004689 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 861360004690 short chain dehydrogenase; Provisional; Region: PRK07806 861360004691 NAD(P) binding site [chemical binding]; other site 861360004692 active site 861360004693 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 861360004694 VanW like protein; Region: VanW; pfam04294 861360004695 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 861360004696 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 861360004697 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 861360004698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360004699 Walker A/P-loop; other site 861360004700 ATP binding site [chemical binding]; other site 861360004701 Q-loop/lid; other site 861360004702 ABC transporter signature motif; other site 861360004703 Walker B; other site 861360004704 D-loop; other site 861360004705 H-loop/switch region; other site 861360004706 hypothetical protein; Provisional; Region: PRK10621 861360004707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 861360004708 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 861360004709 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 861360004710 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 861360004711 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 861360004712 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 861360004713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360004714 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 861360004715 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 861360004716 Zn binding site [ion binding]; other site 861360004717 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 861360004718 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 861360004719 inhibitor site; inhibition site 861360004720 active site 861360004721 dimer interface [polypeptide binding]; other site 861360004722 catalytic residue [active] 861360004723 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 861360004724 putative dimer interface [polypeptide binding]; other site 861360004725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360004726 acyl-coenzyme A oxidase; Region: PLN02636 861360004727 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360004728 active site 861360004729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360004730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360004731 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 861360004732 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360004733 dimer interface [polypeptide binding]; other site 861360004734 active site 861360004735 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 861360004736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360004737 NAD(P) binding site [chemical binding]; other site 861360004738 active site 861360004739 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 861360004740 active site 2 [active] 861360004741 active site 1 [active] 861360004742 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 861360004743 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 861360004744 putative ADP-binding pocket [chemical binding]; other site 861360004745 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 861360004746 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 861360004747 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 861360004748 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 861360004749 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 861360004750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360004752 active site 861360004753 phosphorylation site [posttranslational modification] 861360004754 intermolecular recognition site; other site 861360004755 dimerization interface [polypeptide binding]; other site 861360004756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360004757 DNA binding site [nucleotide binding] 861360004758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360004759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 861360004760 dimerization interface [polypeptide binding]; other site 861360004761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360004762 dimer interface [polypeptide binding]; other site 861360004763 phosphorylation site [posttranslational modification] 861360004764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360004765 ATP binding site [chemical binding]; other site 861360004766 Mg2+ binding site [ion binding]; other site 861360004767 G-X-G motif; other site 861360004768 hypothetical protein; Provisional; Region: PRK07906 861360004769 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 861360004770 putative metal binding site [ion binding]; other site 861360004771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360004772 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 861360004773 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360004774 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 861360004775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360004776 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 861360004777 active site 861360004778 HIGH motif; other site 861360004779 nucleotide binding site [chemical binding]; other site 861360004780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360004781 active site 861360004782 KMSKS motif; other site 861360004783 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 861360004784 tRNA binding surface [nucleotide binding]; other site 861360004785 anticodon binding site; other site 861360004786 PAC2 family; Region: PAC2; pfam09754 861360004787 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 861360004788 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 861360004789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360004790 motif II; other site 861360004791 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 861360004792 Peptidase family M50; Region: Peptidase_M50; pfam02163 861360004793 active site 861360004794 putative substrate binding region [chemical binding]; other site 861360004795 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 861360004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004797 S-adenosylmethionine binding site [chemical binding]; other site 861360004798 proteasome ATPase; Region: pup_AAA; TIGR03689 861360004799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360004800 Walker A motif; other site 861360004801 ATP binding site [chemical binding]; other site 861360004802 Walker B motif; other site 861360004803 arginine finger; other site 861360004804 Pup-ligase protein; Region: Pup_ligase; pfam03136 861360004805 Pup-like protein; Region: Pup; pfam05639 861360004806 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 861360004807 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 861360004808 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 861360004809 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 861360004810 Predicted transcriptional regulator [Transcription]; Region: COG2378 861360004811 WYL domain; Region: WYL; pfam13280 861360004812 Predicted transcriptional regulator [Transcription]; Region: COG2378 861360004813 WYL domain; Region: WYL; pfam13280 861360004814 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 861360004815 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 861360004816 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 861360004817 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 861360004818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360004819 ATP binding site [chemical binding]; other site 861360004820 putative Mg++ binding site [ion binding]; other site 861360004821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360004822 nucleotide binding region [chemical binding]; other site 861360004823 ATP-binding site [chemical binding]; other site 861360004824 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 861360004825 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 861360004826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 861360004827 active site 861360004828 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 861360004829 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 861360004830 Ligand binding site; other site 861360004831 Putative Catalytic site; other site 861360004832 DXD motif; other site 861360004833 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 861360004834 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 861360004835 HflK protein; Region: hflK; TIGR01933 861360004836 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 861360004837 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 861360004838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360004839 S-adenosylmethionine binding site [chemical binding]; other site 861360004840 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 861360004841 active site 861360004842 catalytic residues [active] 861360004843 metal binding site [ion binding]; metal-binding site 861360004844 Predicted ATPase [General function prediction only]; Region: COG1485 861360004845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360004846 dimerization interface [polypeptide binding]; other site 861360004847 putative DNA binding site [nucleotide binding]; other site 861360004848 putative Zn2+ binding site [ion binding]; other site 861360004849 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 861360004850 hydrophobic ligand binding site; other site 861360004851 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 861360004852 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 861360004853 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 861360004854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360004855 DNA binding residues [nucleotide binding] 861360004856 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360004857 AsnC family; Region: AsnC_trans_reg; pfam01037 861360004858 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 861360004859 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 861360004860 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 861360004861 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 861360004862 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 861360004863 Cytochrome c; Region: Cytochrom_C; pfam00034 861360004864 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 861360004865 CCC1-related family of proteins; Region: CCC1_like; cd01059 861360004866 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 861360004867 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 861360004868 iron-sulfur cluster [ion binding]; other site 861360004869 [2Fe-2S] cluster binding site [ion binding]; other site 861360004870 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 861360004871 intrachain domain interface; other site 861360004872 interchain domain interface [polypeptide binding]; other site 861360004873 heme bL binding site [chemical binding]; other site 861360004874 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 861360004875 heme bH binding site [chemical binding]; other site 861360004876 Qo binding site; other site 861360004877 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 861360004878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360004879 DNA-binding site [nucleotide binding]; DNA binding site 861360004880 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 861360004881 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 861360004882 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 861360004883 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 861360004884 D-pathway; other site 861360004885 Putative ubiquinol binding site [chemical binding]; other site 861360004886 Low-spin heme (heme b) binding site [chemical binding]; other site 861360004887 Putative water exit pathway; other site 861360004888 Binuclear center (heme o3/CuB) [ion binding]; other site 861360004889 K-pathway; other site 861360004890 Putative proton exit pathway; other site 861360004891 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 861360004892 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 861360004893 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 861360004894 hypothetical protein; Provisional; Region: PRK07907 861360004895 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 861360004896 active site 861360004897 metal binding site [ion binding]; metal-binding site 861360004898 dimer interface [polypeptide binding]; other site 861360004899 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 861360004900 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 861360004901 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 861360004902 quinone interaction residues [chemical binding]; other site 861360004903 active site 861360004904 catalytic residues [active] 861360004905 FMN binding site [chemical binding]; other site 861360004906 substrate binding site [chemical binding]; other site 861360004907 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 861360004908 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 861360004909 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 861360004910 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 861360004911 catalytic residue [active] 861360004912 putative FPP diphosphate binding site; other site 861360004913 putative FPP binding hydrophobic cleft; other site 861360004914 dimer interface [polypeptide binding]; other site 861360004915 putative IPP diphosphate binding site; other site 861360004916 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 861360004917 Recombination protein O N terminal; Region: RecO_N; pfam11967 861360004918 Recombination protein O C terminal; Region: RecO_C; pfam02565 861360004919 2-isopropylmalate synthase; Validated; Region: PRK03739 861360004920 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 861360004921 active site 861360004922 catalytic residues [active] 861360004923 metal binding site [ion binding]; metal-binding site 861360004924 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 861360004925 hypothetical protein; Provisional; Region: PRK07236 861360004926 hypothetical protein; Provisional; Region: PRK07588 861360004927 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 861360004928 GTPase Era; Reviewed; Region: era; PRK00089 861360004929 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 861360004930 G1 box; other site 861360004931 GTP/Mg2+ binding site [chemical binding]; other site 861360004932 Switch I region; other site 861360004933 G2 box; other site 861360004934 Switch II region; other site 861360004935 G3 box; other site 861360004936 G4 box; other site 861360004937 G5 box; other site 861360004938 KH domain; Region: KH_2; pfam07650 861360004939 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 861360004940 Domain of unknown function DUF21; Region: DUF21; pfam01595 861360004941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 861360004942 Transporter associated domain; Region: CorC_HlyC; smart01091 861360004943 metal-binding heat shock protein; Provisional; Region: PRK00016 861360004944 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 861360004945 PhoH-like protein; Region: PhoH; pfam02562 861360004946 Sporulation and spore germination; Region: Germane; cl11253 861360004947 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 861360004948 RNA methyltransferase, RsmE family; Region: TIGR00046 861360004949 chaperone protein DnaJ; Provisional; Region: PRK14278 861360004950 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 861360004951 HSP70 interaction site [polypeptide binding]; other site 861360004952 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 861360004953 Zn binding sites [ion binding]; other site 861360004954 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 861360004955 dimer interface [polypeptide binding]; other site 861360004956 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 861360004957 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 861360004958 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 861360004959 Tic20-like protein; Region: Tic20; pfam09685 861360004960 coproporphyrinogen III oxidase; Validated; Region: PRK05628 861360004961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360004962 FeS/SAM binding site; other site 861360004963 GTP-binding protein LepA; Provisional; Region: PRK05433 861360004964 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 861360004965 G1 box; other site 861360004966 putative GEF interaction site [polypeptide binding]; other site 861360004967 GTP/Mg2+ binding site [chemical binding]; other site 861360004968 Switch I region; other site 861360004969 G2 box; other site 861360004970 G3 box; other site 861360004971 Switch II region; other site 861360004972 G4 box; other site 861360004973 G5 box; other site 861360004974 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 861360004975 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 861360004976 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 861360004977 PemK-like protein; Region: PemK; pfam02452 861360004978 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 861360004979 hypothetical protein; Reviewed; Region: PRK07914 861360004980 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 861360004981 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 861360004982 Competence protein; Region: Competence; pfam03772 861360004983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360004984 SLBB domain; Region: SLBB; pfam10531 861360004985 comEA protein; Region: comE; TIGR01259 861360004986 EDD domain protein, DegV family; Region: DegV; TIGR00762 861360004987 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 861360004988 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 861360004989 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 861360004990 HIGH motif; other site 861360004991 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 861360004992 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360004993 active site 861360004994 KMSKS motif; other site 861360004995 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 861360004996 tRNA binding surface [nucleotide binding]; other site 861360004997 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 861360004998 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360004999 active site 861360005000 glycerol kinase; Provisional; Region: glpK; PRK00047 861360005001 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 861360005002 N- and C-terminal domain interface [polypeptide binding]; other site 861360005003 active site 861360005004 MgATP binding site [chemical binding]; other site 861360005005 catalytic site [active] 861360005006 metal binding site [ion binding]; metal-binding site 861360005007 putative homotetramer interface [polypeptide binding]; other site 861360005008 glycerol binding site [chemical binding]; other site 861360005009 homodimer interface [polypeptide binding]; other site 861360005010 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 861360005011 amphipathic channel; other site 861360005012 Asn-Pro-Ala signature motifs; other site 861360005013 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 861360005014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360005015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360005016 DNA binding residues [nucleotide binding] 861360005017 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 861360005018 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 861360005019 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 861360005020 primosome assembly protein PriA; Provisional; Region: PRK14873 861360005021 S-adenosylmethionine synthetase; Validated; Region: PRK05250 861360005022 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 861360005023 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 861360005024 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 861360005025 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 861360005026 Flavoprotein; Region: Flavoprotein; pfam02441 861360005027 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 861360005028 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 861360005029 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 861360005030 Guanylate kinase; Region: Guanylate_kin; pfam00625 861360005031 catalytic site [active] 861360005032 G-X2-G-X-G-K; other site 861360005033 DNA topoisomerase VI subunit B; Validated; Region: PRK04184 861360005034 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 861360005035 active site 861360005036 dimer interface [polypeptide binding]; other site 861360005037 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 861360005038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360005039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360005040 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 861360005041 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360005042 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360005043 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 861360005044 IMP binding site; other site 861360005045 dimer interface [polypeptide binding]; other site 861360005046 interdomain contacts; other site 861360005047 partial ornithine binding site; other site 861360005048 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 861360005049 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 861360005050 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 861360005051 catalytic site [active] 861360005052 subunit interface [polypeptide binding]; other site 861360005053 dihydroorotase; Validated; Region: pyrC; PRK09357 861360005054 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 861360005055 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 861360005056 active site 861360005057 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 861360005058 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 861360005059 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 861360005060 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 861360005061 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 861360005062 transcription antitermination factor NusB; Region: nusB; TIGR01951 861360005063 elongation factor P; Validated; Region: PRK00529 861360005064 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 861360005065 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 861360005066 RNA binding site [nucleotide binding]; other site 861360005067 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 861360005068 RNA binding site [nucleotide binding]; other site 861360005069 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 861360005070 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 861360005071 active site 861360005072 dimer interface [polypeptide binding]; other site 861360005073 metal binding site [ion binding]; metal-binding site 861360005074 shikimate kinase; Reviewed; Region: aroK; PRK00131 861360005075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 861360005076 ADP binding site [chemical binding]; other site 861360005077 magnesium binding site [ion binding]; other site 861360005078 putative shikimate binding site; other site 861360005079 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 861360005080 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 861360005081 Tetramer interface [polypeptide binding]; other site 861360005082 active site 861360005083 FMN-binding site [chemical binding]; other site 861360005084 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 861360005085 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 861360005086 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 861360005087 shikimate binding site; other site 861360005088 NAD(P) binding site [chemical binding]; other site 861360005089 YceG-like family; Region: YceG; pfam02618 861360005090 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 861360005091 dimerization interface [polypeptide binding]; other site 861360005092 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 861360005093 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 861360005094 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 861360005095 motif 1; other site 861360005096 active site 861360005097 motif 2; other site 861360005098 motif 3; other site 861360005099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 861360005100 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 861360005101 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 861360005102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360005103 RNA binding surface [nucleotide binding]; other site 861360005104 recombination factor protein RarA; Reviewed; Region: PRK13342 861360005105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360005106 Walker A motif; other site 861360005107 ATP binding site [chemical binding]; other site 861360005108 Walker B motif; other site 861360005109 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 861360005110 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 861360005111 putative active site [active] 861360005112 dimerization interface [polypeptide binding]; other site 861360005113 putative tRNAtyr binding site [nucleotide binding]; other site 861360005114 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360005115 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360005116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360005117 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360005118 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 861360005119 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 861360005120 dimer interface [polypeptide binding]; other site 861360005121 anticodon binding site; other site 861360005122 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 861360005123 homodimer interface [polypeptide binding]; other site 861360005124 motif 1; other site 861360005125 active site 861360005126 motif 2; other site 861360005127 GAD domain; Region: GAD; pfam02938 861360005128 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 861360005129 active site 861360005130 motif 3; other site 861360005131 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 861360005132 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 861360005133 dimer interface [polypeptide binding]; other site 861360005134 motif 1; other site 861360005135 active site 861360005136 motif 2; other site 861360005137 motif 3; other site 861360005138 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 861360005139 anticodon binding site; other site 861360005140 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 861360005141 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 861360005142 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 861360005143 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 861360005144 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 861360005145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 861360005146 Zn2+ binding site [ion binding]; other site 861360005147 Mg2+ binding site [ion binding]; other site 861360005148 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 861360005149 synthetase active site [active] 861360005150 NTP binding site [chemical binding]; other site 861360005151 metal binding site [ion binding]; metal-binding site 861360005152 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 861360005153 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 861360005154 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 861360005155 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 861360005156 Protein export membrane protein; Region: SecD_SecF; cl14618 861360005157 protein-export membrane protein SecD; Region: secD; TIGR01129 861360005158 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 861360005159 Preprotein translocase subunit; Region: YajC; pfam02699 861360005160 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 861360005161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360005162 Walker A motif; other site 861360005163 ATP binding site [chemical binding]; other site 861360005164 Walker B motif; other site 861360005165 arginine finger; other site 861360005166 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 861360005167 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 861360005168 RuvA N terminal domain; Region: RuvA_N; pfam01330 861360005169 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 861360005170 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 861360005171 active site 861360005172 putative DNA-binding cleft [nucleotide binding]; other site 861360005173 dimer interface [polypeptide binding]; other site 861360005174 hypothetical protein; Validated; Region: PRK00110 861360005175 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 861360005176 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 861360005177 predicted active site [active] 861360005178 catalytic triad [active] 861360005179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360005180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360005181 active site 861360005182 catalytic tetrad [active] 861360005183 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 861360005184 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 861360005185 putative active site [active] 861360005186 putative metal binding site [ion binding]; other site 861360005187 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 861360005188 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 861360005189 active site 861360005190 Zn binding site [ion binding]; other site 861360005191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360005192 Coenzyme A binding pocket [chemical binding]; other site 861360005193 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 861360005194 RibD C-terminal domain; Region: RibD_C; cl17279 861360005195 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 861360005196 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 861360005197 active site 861360005198 multimer interface [polypeptide binding]; other site 861360005199 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 861360005200 nucleotide binding site/active site [active] 861360005201 HIT family signature motif; other site 861360005202 catalytic residue [active] 861360005203 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 861360005204 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 861360005205 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 861360005206 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 861360005207 active site 861360005208 dimer interface [polypeptide binding]; other site 861360005209 motif 1; other site 861360005210 motif 2; other site 861360005211 motif 3; other site 861360005212 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 861360005213 anticodon binding site; other site 861360005214 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 861360005215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360005216 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 861360005217 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 861360005218 active site 861360005219 PHP Thumb interface [polypeptide binding]; other site 861360005220 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 861360005221 generic binding surface II; other site 861360005222 generic binding surface I; other site 861360005223 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 861360005224 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 861360005225 NAD binding site [chemical binding]; other site 861360005226 catalytic Zn binding site [ion binding]; other site 861360005227 substrate binding site [chemical binding]; other site 861360005228 structural Zn binding site [ion binding]; other site 861360005229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360005230 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 861360005231 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 861360005232 catalytic residues [active] 861360005233 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 861360005234 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 861360005235 active site 861360005236 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 861360005237 Inter-alpha-trypsin inhibitor heavy chain C-terminus; Region: ITI_HC_C; pfam06668 861360005238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360005239 non-specific DNA binding site [nucleotide binding]; other site 861360005240 salt bridge; other site 861360005241 sequence-specific DNA binding site [nucleotide binding]; other site 861360005242 Cupin domain; Region: Cupin_2; pfam07883 861360005243 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 861360005244 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 861360005245 DNA-binding site [nucleotide binding]; DNA binding site 861360005246 RNA-binding motif; other site 861360005247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 861360005248 Integrase core domain; Region: rve; pfam00665 861360005249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360005250 Transposase; Region: HTH_Tnp_1; pfam01527 861360005251 putative transposase OrfB; Reviewed; Region: PHA02517 861360005252 HTH-like domain; Region: HTH_21; pfam13276 861360005253 Integrase core domain; Region: rve; pfam00665 861360005254 Integrase core domain; Region: rve_3; pfam13683 861360005255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360005256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360005257 putative substrate translocation pore; other site 861360005258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360005259 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 861360005260 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 861360005261 dimer interface [polypeptide binding]; other site 861360005262 putative radical transfer pathway; other site 861360005263 diiron center [ion binding]; other site 861360005264 tyrosyl radical; other site 861360005265 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 861360005266 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 861360005267 Class I ribonucleotide reductase; Region: RNR_I; cd01679 861360005268 active site 861360005269 dimer interface [polypeptide binding]; other site 861360005270 catalytic residues [active] 861360005271 effector binding site; other site 861360005272 R2 peptide binding site; other site 861360005273 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 861360005274 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 861360005275 catalytic residues [active] 861360005276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 861360005277 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360005278 catalytic residue [active] 861360005279 pyruvate dehydrogenase; Provisional; Region: PRK09124 861360005280 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 861360005281 PYR/PP interface [polypeptide binding]; other site 861360005282 dimer interface [polypeptide binding]; other site 861360005283 tetramer interface [polypeptide binding]; other site 861360005284 TPP binding site [chemical binding]; other site 861360005285 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360005286 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 861360005287 TPP-binding site [chemical binding]; other site 861360005288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 861360005289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360005290 catalytic residue [active] 861360005291 Cupin domain; Region: Cupin_2; cl17218 861360005292 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 861360005293 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 861360005294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360005295 catalytic residue [active] 861360005296 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 861360005297 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 861360005298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360005299 Walker A/P-loop; other site 861360005300 ATP binding site [chemical binding]; other site 861360005301 Q-loop/lid; other site 861360005302 ABC transporter signature motif; other site 861360005303 Walker B; other site 861360005304 D-loop; other site 861360005305 H-loop/switch region; other site 861360005306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360005307 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 861360005308 L-aspartate oxidase; Provisional; Region: PRK06175 861360005309 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 861360005310 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360005311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 861360005312 dimerization interface [polypeptide binding]; other site 861360005313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360005314 TIGR01777 family protein; Region: yfcH 861360005315 NAD(P) binding site [chemical binding]; other site 861360005316 active site 861360005317 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 861360005318 dimer interface [polypeptide binding]; other site 861360005319 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 861360005320 dimer interface [polypeptide binding]; other site 861360005321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360005322 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 861360005323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360005324 NAD(P) binding site [chemical binding]; other site 861360005325 active site 861360005326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360005327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360005328 putative DNA binding site [nucleotide binding]; other site 861360005329 putative Zn2+ binding site [ion binding]; other site 861360005330 AsnC family; Region: AsnC_trans_reg; pfam01037 861360005331 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 861360005332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360005333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360005334 homodimer interface [polypeptide binding]; other site 861360005335 catalytic residue [active] 861360005336 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 861360005337 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 861360005338 A new structural DNA glycosylase; Region: AlkD_like; cl11434 861360005339 active site 861360005340 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 861360005341 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 861360005342 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 861360005343 oligomer interface [polypeptide binding]; other site 861360005344 metal binding site [ion binding]; metal-binding site 861360005345 metal binding site [ion binding]; metal-binding site 861360005346 putative Cl binding site [ion binding]; other site 861360005347 basic sphincter; other site 861360005348 hydrophobic gate; other site 861360005349 periplasmic entrance; other site 861360005350 Domain of unknown function (DUF222); Region: DUF222; pfam02720 861360005351 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360005352 active site 861360005353 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 861360005354 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 861360005355 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 861360005356 active site 861360005357 (T/H)XGH motif; other site 861360005358 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 861360005359 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 861360005360 putative catalytic cysteine [active] 861360005361 gamma-glutamyl kinase; Provisional; Region: PRK05429 861360005362 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 861360005363 homotetrameric interface [polypeptide binding]; other site 861360005364 putative phosphate binding site [ion binding]; other site 861360005365 putative allosteric binding site; other site 861360005366 nucleotide binding site [chemical binding]; other site 861360005367 PUA domain; Region: PUA; pfam01472 861360005368 GTPase CgtA; Reviewed; Region: obgE; PRK12296 861360005369 GTP1/OBG; Region: GTP1_OBG; pfam01018 861360005370 Obg GTPase; Region: Obg; cd01898 861360005371 G1 box; other site 861360005372 GTP/Mg2+ binding site [chemical binding]; other site 861360005373 Switch I region; other site 861360005374 G2 box; other site 861360005375 G3 box; other site 861360005376 Switch II region; other site 861360005377 G4 box; other site 861360005378 G5 box; other site 861360005379 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 861360005380 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 861360005381 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 861360005382 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 861360005383 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 861360005384 homodimer interface [polypeptide binding]; other site 861360005385 oligonucleotide binding site [chemical binding]; other site 861360005386 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 861360005387 putative active site [active] 861360005388 redox center [active] 861360005389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360005390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360005391 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 861360005392 Domain of unknown function DUF20; Region: UPF0118; pfam01594 861360005393 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 861360005394 active site 861360005395 multimer interface [polypeptide binding]; other site 861360005396 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 861360005397 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 861360005398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 861360005399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 861360005400 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 861360005401 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 861360005402 HIGH motif; other site 861360005403 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 861360005404 active site 861360005405 KMSKS motif; other site 861360005406 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 861360005407 tRNA binding surface [nucleotide binding]; other site 861360005408 anticodon binding site; other site 861360005409 Protein of unknown function (DUF421); Region: DUF421; pfam04239 861360005410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360005411 Histidine kinase; Region: HisKA_3; pfam07730 861360005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360005413 ATP binding site [chemical binding]; other site 861360005414 Mg2+ binding site [ion binding]; other site 861360005415 G-X-G motif; other site 861360005416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360005417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360005418 active site 861360005419 phosphorylation site [posttranslational modification] 861360005420 intermolecular recognition site; other site 861360005421 dimerization interface [polypeptide binding]; other site 861360005422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360005423 DNA binding residues [nucleotide binding] 861360005424 dimerization interface [polypeptide binding]; other site 861360005425 MMPL family; Region: MMPL; pfam03176 861360005426 MMPL family; Region: MMPL; pfam03176 861360005427 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 861360005428 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 861360005429 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 861360005430 active site 861360005431 catalytic site [active] 861360005432 substrate binding site [chemical binding]; other site 861360005433 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 861360005434 Dimer interface [polypeptide binding]; other site 861360005435 BRCT sequence motif; other site 861360005436 ferredoxin-NADP+ reductase; Region: PLN02852 861360005437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360005438 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 861360005439 active site 861360005440 SAM binding site [chemical binding]; other site 861360005441 homodimer interface [polypeptide binding]; other site 861360005442 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 861360005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360005444 dimer interface [polypeptide binding]; other site 861360005445 conserved gate region; other site 861360005446 ABC-ATPase subunit interface; other site 861360005447 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 861360005448 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 861360005449 Walker A/P-loop; other site 861360005450 ATP binding site [chemical binding]; other site 861360005451 Q-loop/lid; other site 861360005452 ABC transporter signature motif; other site 861360005453 Walker B; other site 861360005454 D-loop; other site 861360005455 H-loop/switch region; other site 861360005456 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 861360005457 NMT1-like family; Region: NMT1_2; pfam13379 861360005458 substrate binding pocket [chemical binding]; other site 861360005459 membrane-bound complex binding site; other site 861360005460 hinge residues; other site 861360005461 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 861360005462 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 861360005463 CysD dimerization site [polypeptide binding]; other site 861360005464 G1 box; other site 861360005465 putative GEF interaction site [polypeptide binding]; other site 861360005466 GTP/Mg2+ binding site [chemical binding]; other site 861360005467 Switch I region; other site 861360005468 G2 box; other site 861360005469 G3 box; other site 861360005470 Switch II region; other site 861360005471 G4 box; other site 861360005472 G5 box; other site 861360005473 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 861360005474 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 861360005475 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 861360005476 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 861360005477 Active Sites [active] 861360005478 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 861360005479 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 861360005480 Active Sites [active] 861360005481 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 861360005482 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 861360005483 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 861360005484 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 861360005485 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 861360005486 putative active site [active] 861360005487 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 861360005488 putative active site [active] 861360005489 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 861360005490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360005491 NAD(P) binding site [chemical binding]; other site 861360005492 active site 861360005493 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 861360005494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360005495 active site 861360005496 HIGH motif; other site 861360005497 nucleotide binding site [chemical binding]; other site 861360005498 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 861360005499 active site 861360005500 KMSKS motif; other site 861360005501 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 861360005502 tRNA binding surface [nucleotide binding]; other site 861360005503 anticodon binding site; other site 861360005504 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 861360005505 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 861360005506 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360005507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360005508 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360005509 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 861360005510 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 861360005511 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 861360005512 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 861360005513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360005514 Walker A motif; other site 861360005515 ATP binding site [chemical binding]; other site 861360005516 Walker B motif; other site 861360005517 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 861360005518 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 861360005519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 861360005520 oligomer interface [polypeptide binding]; other site 861360005521 active site residues [active] 861360005522 Clp protease; Region: CLP_protease; pfam00574 861360005523 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 861360005524 oligomer interface [polypeptide binding]; other site 861360005525 active site residues [active] 861360005526 trigger factor; Provisional; Region: tig; PRK01490 861360005527 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 861360005528 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 861360005529 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 861360005530 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 861360005531 putative DNA binding site [nucleotide binding]; other site 861360005532 catalytic residue [active] 861360005533 putative H2TH interface [polypeptide binding]; other site 861360005534 putative catalytic residues [active] 861360005535 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 861360005536 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 861360005537 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 861360005538 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 861360005539 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 861360005540 Zn binding site [ion binding]; other site 861360005541 Winged helix-turn helix; Region: HTH_29; pfam13551 861360005542 Homeodomain-like domain; Region: HTH_32; pfam13565 861360005543 Integrase core domain; Region: rve; pfam00665 861360005544 DDE domain; Region: DDE_Tnp_IS240; pfam13610 861360005545 Integrase core domain; Region: rve_3; pfam13683 861360005546 OsmC-like protein; Region: OsmC; cl00767 861360005547 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 861360005548 apolar tunnel; other site 861360005549 heme binding site [chemical binding]; other site 861360005550 dimerization interface [polypeptide binding]; other site 861360005551 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 861360005552 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 861360005553 active site 861360005554 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 861360005555 catalytic triad [active] 861360005556 dimer interface [polypeptide binding]; other site 861360005557 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 861360005558 MOSC domain; Region: MOSC; pfam03473 861360005559 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 861360005560 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 861360005561 FAD binding pocket [chemical binding]; other site 861360005562 conserved FAD binding motif [chemical binding]; other site 861360005563 phosphate binding motif [ion binding]; other site 861360005564 beta-alpha-beta structure motif; other site 861360005565 NAD binding pocket [chemical binding]; other site 861360005566 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 861360005567 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 861360005568 catalytic loop [active] 861360005569 iron binding site [ion binding]; other site 861360005570 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 861360005571 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 861360005572 DNA binding residues [nucleotide binding] 861360005573 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 861360005574 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 861360005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360005576 Walker A/P-loop; other site 861360005577 ATP binding site [chemical binding]; other site 861360005578 Q-loop/lid; other site 861360005579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360005580 ABC transporter; Region: ABC_tran_2; pfam12848 861360005581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 861360005582 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 861360005583 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 861360005584 dimer interface [polypeptide binding]; other site 861360005585 ssDNA binding site [nucleotide binding]; other site 861360005586 tetramer (dimer of dimers) interface [polypeptide binding]; other site 861360005587 CAAX protease self-immunity; Region: Abi; cl00558 861360005588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360005589 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 861360005590 FAD binding domain; Region: FAD_binding_2; pfam00890 861360005591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360005592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360005593 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360005594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360005595 putative DNA binding site [nucleotide binding]; other site 861360005596 putative Zn2+ binding site [ion binding]; other site 861360005597 AsnC family; Region: AsnC_trans_reg; pfam01037 861360005598 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 861360005599 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 861360005600 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 861360005601 Walker A/P-loop; other site 861360005602 ATP binding site [chemical binding]; other site 861360005603 Q-loop/lid; other site 861360005604 ABC transporter signature motif; other site 861360005605 Walker B; other site 861360005606 D-loop; other site 861360005607 H-loop/switch region; other site 861360005608 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 861360005609 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 861360005610 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 861360005611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360005612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360005613 acyl-activating enzyme (AAE) consensus motif; other site 861360005614 acyl-activating enzyme (AAE) consensus motif; other site 861360005615 AMP binding site [chemical binding]; other site 861360005616 active site 861360005617 CoA binding site [chemical binding]; other site 861360005618 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360005619 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 861360005620 dimer interface [polypeptide binding]; other site 861360005621 active site 861360005622 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 861360005623 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 861360005624 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 861360005625 Walker A/P-loop; other site 861360005626 ATP binding site [chemical binding]; other site 861360005627 Q-loop/lid; other site 861360005628 ABC transporter signature motif; other site 861360005629 Walker B; other site 861360005630 D-loop; other site 861360005631 H-loop/switch region; other site 861360005632 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 861360005633 FeS assembly protein SufD; Region: sufD; TIGR01981 861360005634 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 861360005635 FeS assembly protein SufB; Region: sufB; TIGR01980 861360005636 Predicted transcriptional regulator [Transcription]; Region: COG2345 861360005637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360005638 putative DNA binding site [nucleotide binding]; other site 861360005639 putative Zn2+ binding site [ion binding]; other site 861360005640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 861360005641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 861360005642 Walker A/P-loop; other site 861360005643 ATP binding site [chemical binding]; other site 861360005644 Q-loop/lid; other site 861360005645 ABC transporter signature motif; other site 861360005646 Walker B; other site 861360005647 D-loop; other site 861360005648 H-loop/switch region; other site 861360005649 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 861360005650 ABC-2 type transporter; Region: ABC2_membrane; cl17235 861360005651 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 861360005652 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 861360005653 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 861360005654 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360005655 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360005656 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 861360005657 UbiA prenyltransferase family; Region: UbiA; pfam01040 861360005658 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 861360005659 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 861360005660 TPP-binding site [chemical binding]; other site 861360005661 dimer interface [polypeptide binding]; other site 861360005662 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 861360005663 PYR/PP interface [polypeptide binding]; other site 861360005664 dimer interface [polypeptide binding]; other site 861360005665 TPP binding site [chemical binding]; other site 861360005666 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 861360005667 putative active site [active] 861360005668 transaldolase; Provisional; Region: PRK03903 861360005669 catalytic residue [active] 861360005670 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 861360005671 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 861360005672 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 861360005673 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 861360005674 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 861360005675 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 861360005676 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 861360005677 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 861360005678 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 861360005679 putative active site [active] 861360005680 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 861360005681 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 861360005682 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 861360005683 homodimer interface [polypeptide binding]; other site 861360005684 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 861360005685 active site pocket [active] 861360005686 glycogen branching enzyme; Provisional; Region: PRK05402 861360005687 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 861360005688 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 861360005689 active site 861360005690 catalytic site [active] 861360005691 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 861360005692 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 861360005693 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 861360005694 ligand binding site; other site 861360005695 oligomer interface; other site 861360005696 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 861360005697 dimer interface [polypeptide binding]; other site 861360005698 N-terminal domain interface [polypeptide binding]; other site 861360005699 sulfate 1 binding site; other site 861360005700 glycogen synthase; Provisional; Region: glgA; PRK00654 861360005701 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 861360005702 ADP-binding pocket [chemical binding]; other site 861360005703 homodimer interface [polypeptide binding]; other site 861360005704 triosephosphate isomerase; Provisional; Region: PRK14567 861360005705 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 861360005706 substrate binding site [chemical binding]; other site 861360005707 dimer interface [polypeptide binding]; other site 861360005708 catalytic triad [active] 861360005709 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 861360005710 Phosphoglycerate kinase; Region: PGK; pfam00162 861360005711 substrate binding site [chemical binding]; other site 861360005712 hinge regions; other site 861360005713 ADP binding site [chemical binding]; other site 861360005714 catalytic site [active] 861360005715 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 861360005716 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 861360005717 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 861360005718 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 861360005719 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 861360005720 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 861360005721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 861360005722 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 861360005723 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 861360005724 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 861360005725 putative substrate binding pocket [chemical binding]; other site 861360005726 dimer interface [polypeptide binding]; other site 861360005727 phosphate binding site [ion binding]; other site 861360005728 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 861360005729 AAA domain; Region: AAA_18; pfam13238 861360005730 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 861360005731 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 861360005732 GIY-YIG motif/motif A; other site 861360005733 active site 861360005734 catalytic site [active] 861360005735 putative DNA binding site [nucleotide binding]; other site 861360005736 metal binding site [ion binding]; metal-binding site 861360005737 UvrB/uvrC motif; Region: UVR; pfam02151 861360005738 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 861360005739 Helix-hairpin-helix motif; Region: HHH; pfam00633 861360005740 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 861360005741 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 861360005742 putative acyl-acceptor binding pocket; other site 861360005743 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 861360005744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360005745 motif II; other site 861360005746 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 861360005747 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 861360005748 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 861360005749 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 861360005750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360005751 DNA-binding site [nucleotide binding]; DNA binding site 861360005752 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 861360005753 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 861360005754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360005755 S-adenosylmethionine binding site [chemical binding]; other site 861360005756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360005757 ATP binding site [chemical binding]; other site 861360005758 putative Mg++ binding site [ion binding]; other site 861360005759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360005760 nucleotide binding region [chemical binding]; other site 861360005761 ATP-binding site [chemical binding]; other site 861360005762 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 861360005763 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 861360005764 nudix motif; other site 861360005765 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360005766 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360005767 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 861360005768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 861360005769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360005770 Coenzyme A binding pocket [chemical binding]; other site 861360005771 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 861360005772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360005773 MarR family; Region: MarR_2; cl17246 861360005774 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 861360005775 excinuclease ABC subunit B; Provisional; Region: PRK05298 861360005776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 861360005777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360005778 nucleotide binding region [chemical binding]; other site 861360005779 ATP-binding site [chemical binding]; other site 861360005780 Ultra-violet resistance protein B; Region: UvrB; pfam12344 861360005781 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 861360005782 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 861360005783 CoA-binding site [chemical binding]; other site 861360005784 ATP-binding [chemical binding]; other site 861360005785 Uncharacterized conserved protein [Function unknown]; Region: COG1739 861360005786 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 861360005787 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 861360005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 861360005789 S-adenosylmethionine binding site [chemical binding]; other site 861360005790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360005791 active site 861360005792 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 861360005793 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 861360005794 RNA binding site [nucleotide binding]; other site 861360005795 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 861360005796 RNA binding site [nucleotide binding]; other site 861360005797 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 861360005798 RNA binding site [nucleotide binding]; other site 861360005799 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 861360005800 RNA binding site [nucleotide binding]; other site 861360005801 domain interface; other site 861360005802 hypothetical protein; Provisional; Region: PRK01346 861360005803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 861360005804 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 861360005805 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 861360005806 DNA polymerase I; Provisional; Region: PRK05755 861360005807 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 861360005808 active site 861360005809 putative 5' ssDNA interaction site; other site 861360005810 metal binding site 3; metal-binding site 861360005811 metal binding site 1 [ion binding]; metal-binding site 861360005812 metal binding site 2 [ion binding]; metal-binding site 861360005813 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 861360005814 putative DNA binding site [nucleotide binding]; other site 861360005815 putative metal binding site [ion binding]; other site 861360005816 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 861360005817 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 861360005818 active site 861360005819 DNA binding site [nucleotide binding] 861360005820 catalytic site [active] 861360005821 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 861360005822 CoenzymeA binding site [chemical binding]; other site 861360005823 subunit interaction site [polypeptide binding]; other site 861360005824 PHB binding site; other site 861360005825 RibD C-terminal domain; Region: RibD_C; cl17279 861360005826 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 861360005827 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 861360005828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360005829 active site 861360005830 phosphorylation site [posttranslational modification] 861360005831 intermolecular recognition site; other site 861360005832 dimerization interface [polypeptide binding]; other site 861360005833 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 861360005834 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 861360005835 pyruvate kinase; Provisional; Region: PRK06247 861360005836 domain interfaces; other site 861360005837 active site 861360005838 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 861360005839 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360005840 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 861360005841 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 861360005842 active site 861360005843 dimer interface [polypeptide binding]; other site 861360005844 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 861360005845 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 861360005846 active site 861360005847 FMN binding site [chemical binding]; other site 861360005848 substrate binding site [chemical binding]; other site 861360005849 3Fe-4S cluster binding site [ion binding]; other site 861360005850 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 861360005851 domain interface; other site 861360005852 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 861360005853 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 861360005854 substrate binding site [chemical binding]; other site 861360005855 active site 861360005856 catalytic residues [active] 861360005857 heterodimer interface [polypeptide binding]; other site 861360005858 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 861360005859 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 861360005860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360005861 catalytic residue [active] 861360005862 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 861360005863 active site 861360005864 ribulose/triose binding site [chemical binding]; other site 861360005865 phosphate binding site [ion binding]; other site 861360005866 substrate (anthranilate) binding pocket [chemical binding]; other site 861360005867 product (indole) binding pocket [chemical binding]; other site 861360005868 anthranilate synthase component I; Provisional; Region: PRK13571 861360005869 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 861360005870 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 861360005871 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 861360005872 TIGR03085 family protein; Region: TIGR03085 861360005873 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360005874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360005875 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360005876 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360005877 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360005878 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 861360005879 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 861360005880 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 861360005881 substrate binding site [chemical binding]; other site 861360005882 glutamase interaction surface [polypeptide binding]; other site 861360005883 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 861360005884 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 861360005885 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 861360005886 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 861360005887 metal binding site [ion binding]; metal-binding site 861360005888 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 861360005889 homopentamer interface [polypeptide binding]; other site 861360005890 active site 861360005891 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 861360005892 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 861360005893 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 861360005894 dimerization interface [polypeptide binding]; other site 861360005895 active site 861360005896 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 861360005897 Lumazine binding domain; Region: Lum_binding; pfam00677 861360005898 Lumazine binding domain; Region: Lum_binding; pfam00677 861360005899 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 861360005900 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 861360005901 catalytic motif [active] 861360005902 Zn binding site [ion binding]; other site 861360005903 RibD C-terminal domain; Region: RibD_C; pfam01872 861360005904 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 861360005905 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 861360005906 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 861360005907 substrate binding site [chemical binding]; other site 861360005908 hexamer interface [polypeptide binding]; other site 861360005909 metal binding site [ion binding]; metal-binding site 861360005910 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 861360005911 putative RNA binding site [nucleotide binding]; other site 861360005912 16S rRNA methyltransferase B; Provisional; Region: PRK14902 861360005913 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 861360005914 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 861360005915 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 861360005916 putative active site [active] 861360005917 substrate binding site [chemical binding]; other site 861360005918 putative cosubstrate binding site; other site 861360005919 catalytic site [active] 861360005920 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 861360005921 substrate binding site [chemical binding]; other site 861360005922 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 861360005923 active site 861360005924 catalytic residues [active] 861360005925 metal binding site [ion binding]; metal-binding site 861360005926 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 861360005927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 861360005928 Predicted ATPase [General function prediction only]; Region: COG1485 861360005929 Walker A motif; other site 861360005930 ATP binding site [chemical binding]; other site 861360005931 Walker B motif; other site 861360005932 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 861360005933 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 861360005934 active site residue [active] 861360005935 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 861360005936 active site residue [active] 861360005937 Fe-S metabolism associated domain; Region: SufE; cl00951 861360005938 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 861360005939 putative deacylase active site [active] 861360005940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360005941 methionine sulfoxide reductase B; Provisional; Region: PRK00222 861360005942 SelR domain; Region: SelR; pfam01641 861360005943 classical (c) SDRs; Region: SDR_c; cd05233 861360005944 NAD(P) binding site [chemical binding]; other site 861360005945 active site 861360005946 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 861360005947 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 861360005948 tetramer interface [polypeptide binding]; other site 861360005949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360005950 catalytic residue [active] 861360005951 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 861360005952 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 861360005953 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 861360005954 catalytic site [active] 861360005955 putative active site [active] 861360005956 putative substrate binding site [chemical binding]; other site 861360005957 HRDC domain; Region: HRDC; pfam00570 861360005958 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360005959 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 861360005960 dimer interface [polypeptide binding]; other site 861360005961 active site 861360005962 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 861360005963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360005964 substrate binding site [chemical binding]; other site 861360005965 oxyanion hole (OAH) forming residues; other site 861360005966 trimer interface [polypeptide binding]; other site 861360005967 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 861360005968 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 861360005969 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 861360005970 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 861360005971 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 861360005972 Na binding site [ion binding]; other site 861360005973 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 861360005974 iron-sulfur cluster [ion binding]; other site 861360005975 [2Fe-2S] cluster binding site [ion binding]; other site 861360005976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360005977 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360005978 active site 861360005979 catalytic tetrad [active] 861360005980 argininosuccinate synthase; Validated; Region: PRK05370 861360005981 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 861360005982 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360005983 Protein of unknown function (DUF402); Region: DUF402; cl00979 861360005984 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 861360005985 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 861360005986 TPP-binding site [chemical binding]; other site 861360005987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 861360005988 PYR/PP interface [polypeptide binding]; other site 861360005989 dimer interface [polypeptide binding]; other site 861360005990 TPP binding site [chemical binding]; other site 861360005991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360005992 Phosphotransferase enzyme family; Region: APH; pfam01636 861360005993 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 861360005994 substrate binding site [chemical binding]; other site 861360005995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360005996 S-adenosylmethionine binding site [chemical binding]; other site 861360005997 aconitate hydratase; Validated; Region: PRK09277 861360005998 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 861360005999 substrate binding site [chemical binding]; other site 861360006000 ligand binding site [chemical binding]; other site 861360006001 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 861360006002 substrate binding site [chemical binding]; other site 861360006003 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 861360006004 TRAM domain; Region: TRAM; cl01282 861360006005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360006006 S-adenosylmethionine binding site [chemical binding]; other site 861360006007 Amino acid permease; Region: AA_permease_2; pfam13520 861360006008 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 861360006009 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 861360006010 TrkA-N domain; Region: TrkA_N; pfam02254 861360006011 TrkA-C domain; Region: TrkA_C; pfam02080 861360006012 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 861360006013 TrkA-N domain; Region: TrkA_N; pfam02254 861360006014 TrkA-C domain; Region: TrkA_C; pfam02080 861360006015 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 861360006016 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 861360006017 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 861360006018 trimer interface [polypeptide binding]; other site 861360006019 active site 861360006020 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 861360006021 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 861360006022 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 861360006023 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 861360006024 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 861360006025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 861360006026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360006027 Coenzyme A binding pocket [chemical binding]; other site 861360006028 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 861360006029 CoA binding domain; Region: CoA_binding_2; pfam13380 861360006030 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 861360006031 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 861360006032 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 861360006033 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 861360006034 CAP-like domain; other site 861360006035 active site 861360006036 primary dimer interface [polypeptide binding]; other site 861360006037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 861360006038 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 861360006039 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360006040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360006041 Walker A/P-loop; other site 861360006042 ATP binding site [chemical binding]; other site 861360006043 Q-loop/lid; other site 861360006044 ABC transporter signature motif; other site 861360006045 Walker B; other site 861360006046 D-loop; other site 861360006047 H-loop/switch region; other site 861360006048 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 861360006049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360006050 Q-loop/lid; other site 861360006051 ABC transporter signature motif; other site 861360006052 Walker B; other site 861360006053 D-loop; other site 861360006054 H-loop/switch region; other site 861360006055 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 861360006056 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 861360006057 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 861360006058 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 861360006059 Penicillinase repressor; Region: Pencillinase_R; cl17580 861360006060 Peptidase family M48; Region: Peptidase_M48; cl12018 861360006061 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 861360006062 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 861360006063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360006064 ATP binding site [chemical binding]; other site 861360006065 Mg2+ binding site [ion binding]; other site 861360006066 G-X-G motif; other site 861360006067 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 861360006068 anchoring element; other site 861360006069 dimer interface [polypeptide binding]; other site 861360006070 ATP binding site [chemical binding]; other site 861360006071 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 861360006072 active site 861360006073 metal binding site [ion binding]; metal-binding site 861360006074 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 861360006075 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 861360006076 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 861360006077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360006078 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 861360006079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360006080 DNA binding residues [nucleotide binding] 861360006081 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 861360006082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360006083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360006084 putative substrate translocation pore; other site 861360006085 PAC2 family; Region: PAC2; pfam09754 861360006086 multifunctional aminopeptidase A; Provisional; Region: PRK00913 861360006087 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 861360006088 interface (dimer of trimers) [polypeptide binding]; other site 861360006089 Substrate-binding/catalytic site; other site 861360006090 Zn-binding sites [ion binding]; other site 861360006091 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 861360006092 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360006093 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 861360006094 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 861360006095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360006096 E3 interaction surface; other site 861360006097 lipoyl attachment site [posttranslational modification]; other site 861360006098 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360006099 E3 interaction surface; other site 861360006100 lipoyl attachment site [posttranslational modification]; other site 861360006101 e3 binding domain; Region: E3_binding; pfam02817 861360006102 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 861360006103 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360006104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360006105 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360006106 lipoate-protein ligase B; Provisional; Region: PRK14345 861360006107 lipoyl synthase; Provisional; Region: PRK05481 861360006108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360006109 FeS/SAM binding site; other site 861360006110 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 861360006111 RDD family; Region: RDD; pfam06271 861360006112 glutamine synthetase, type I; Region: GlnA; TIGR00653 861360006113 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 861360006114 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 861360006115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 861360006116 active site 861360006117 DNA binding site [nucleotide binding] 861360006118 Int/Topo IB signature motif; other site 861360006119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360006120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360006121 non-specific DNA binding site [nucleotide binding]; other site 861360006122 salt bridge; other site 861360006123 sequence-specific DNA binding site [nucleotide binding]; other site 861360006124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360006125 Transposase; Region: HTH_Tnp_1; cl17663 861360006126 putative transposase OrfB; Reviewed; Region: PHA02517 861360006127 HTH-like domain; Region: HTH_21; pfam13276 861360006128 Integrase core domain; Region: rve; pfam00665 861360006129 Integrase core domain; Region: rve_3; pfam13683 861360006130 Helix-turn-helix domain; Region: HTH_17; cl17695 861360006131 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 861360006132 DNA binding residues [nucleotide binding] 861360006133 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 861360006134 nucleoside/Zn binding site; other site 861360006135 dimer interface [polypeptide binding]; other site 861360006136 catalytic motif [active] 861360006137 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 861360006138 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 861360006139 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 861360006140 metal binding triad; other site 861360006141 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 861360006142 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 861360006143 metal binding triad; other site 861360006144 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 861360006145 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 861360006146 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 861360006147 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 861360006148 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 861360006149 oligomerization interface [polypeptide binding]; other site 861360006150 active site 861360006151 metal binding site [ion binding]; metal-binding site 861360006152 methionine aminopeptidase; Provisional; Region: PRK12318 861360006153 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 861360006154 active site 861360006155 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 861360006156 ATP cone domain; Region: ATP-cone; pfam03477 861360006157 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 861360006158 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 861360006159 NAD binding site [chemical binding]; other site 861360006160 dimerization interface [polypeptide binding]; other site 861360006161 product binding site; other site 861360006162 substrate binding site [chemical binding]; other site 861360006163 zinc binding site [ion binding]; other site 861360006164 catalytic residues [active] 861360006165 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 861360006166 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 861360006167 active site 861360006168 PHP Thumb interface [polypeptide binding]; other site 861360006169 metal binding site [ion binding]; metal-binding site 861360006170 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 861360006171 generic binding surface I; other site 861360006172 generic binding surface II; other site 861360006173 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 861360006174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360006175 RNA binding surface [nucleotide binding]; other site 861360006176 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 861360006177 active site 861360006178 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 861360006179 DivIVA protein; Region: DivIVA; pfam05103 861360006180 DivIVA domain; Region: DivI1A_domain; TIGR03544 861360006181 Protein of unknown function (DUF552); Region: DUF552; pfam04472 861360006182 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 861360006183 cell division protein FtsZ; Validated; Region: PRK09330 861360006184 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 861360006185 nucleotide binding site [chemical binding]; other site 861360006186 SulA interaction site; other site 861360006187 cell division protein FtsQ; Provisional; Region: PRK05529 861360006188 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 861360006189 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 861360006190 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 861360006191 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 861360006192 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 861360006193 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 861360006194 active site 861360006195 homodimer interface [polypeptide binding]; other site 861360006196 cell division protein FtsW; Region: ftsW; TIGR02614 861360006197 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 861360006198 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 861360006199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 861360006200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 861360006201 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 861360006202 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 861360006203 Mg++ binding site [ion binding]; other site 861360006204 putative catalytic motif [active] 861360006205 putative substrate binding site [chemical binding]; other site 861360006206 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 861360006207 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 861360006208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 861360006209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 861360006210 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 861360006211 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 861360006212 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 861360006213 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 861360006214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 861360006215 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 861360006216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 861360006217 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 861360006218 MraW methylase family; Region: Methyltransf_5; cl17771 861360006219 cell division protein MraZ; Reviewed; Region: PRK00326 861360006220 MraZ protein; Region: MraZ; pfam02381 861360006221 MraZ protein; Region: MraZ; pfam02381 861360006222 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 861360006223 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 861360006224 active site 861360006225 DNA polymerase IV; Validated; Region: PRK02406 861360006226 DNA binding site [nucleotide binding] 861360006227 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 861360006228 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 861360006229 substrate binding pocket [chemical binding]; other site 861360006230 chain length determination region; other site 861360006231 substrate-Mg2+ binding site; other site 861360006232 catalytic residues [active] 861360006233 aspartate-rich region 1; other site 861360006234 active site lid residues [active] 861360006235 aspartate-rich region 2; other site 861360006236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360006237 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360006238 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360006239 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360006240 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 861360006241 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 861360006242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 861360006243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 861360006244 catalytic residue [active] 861360006245 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 861360006246 PAS fold; Region: PAS_4; pfam08448 861360006247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 861360006248 putative active site [active] 861360006249 heme pocket [chemical binding]; other site 861360006250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 861360006251 Histidine kinase; Region: HisKA_2; pfam07568 861360006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360006253 ATP binding site [chemical binding]; other site 861360006254 Mg2+ binding site [ion binding]; other site 861360006255 G-X-G motif; other site 861360006256 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 861360006257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 861360006258 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 861360006259 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 861360006260 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 861360006261 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 861360006262 DEAD/DEAH box helicase; Region: DEAD; pfam00270 861360006263 ATP binding site [chemical binding]; other site 861360006264 putative Mg++ binding site [ion binding]; other site 861360006265 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 861360006266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 861360006267 nucleotide binding region [chemical binding]; other site 861360006268 ATP-binding site [chemical binding]; other site 861360006269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 861360006270 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 861360006271 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 861360006272 30S subunit binding site; other site 861360006273 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 861360006274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360006275 active site 861360006276 lipoprotein LpqB; Provisional; Region: PRK13614 861360006277 Sporulation and spore germination; Region: Germane; pfam10646 861360006278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 861360006279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 861360006280 dimerization interface [polypeptide binding]; other site 861360006281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 861360006282 dimer interface [polypeptide binding]; other site 861360006283 phosphorylation site [posttranslational modification] 861360006284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360006285 ATP binding site [chemical binding]; other site 861360006286 Mg2+ binding site [ion binding]; other site 861360006287 G-X-G motif; other site 861360006288 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360006289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360006290 active site 861360006291 phosphorylation site [posttranslational modification] 861360006292 intermolecular recognition site; other site 861360006293 dimerization interface [polypeptide binding]; other site 861360006294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360006295 DNA binding site [nucleotide binding] 861360006296 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 861360006297 chorismate mutase; Provisional; Region: PRK09239 861360006298 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360006299 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360006300 Walker A/P-loop; other site 861360006301 ATP binding site [chemical binding]; other site 861360006302 Q-loop/lid; other site 861360006303 ABC transporter signature motif; other site 861360006304 Walker B; other site 861360006305 D-loop; other site 861360006306 H-loop/switch region; other site 861360006307 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360006308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360006309 Walker A/P-loop; other site 861360006310 ATP binding site [chemical binding]; other site 861360006311 Q-loop/lid; other site 861360006312 ABC transporter signature motif; other site 861360006313 Walker B; other site 861360006314 D-loop; other site 861360006315 H-loop/switch region; other site 861360006316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360006317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 861360006318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006319 dimer interface [polypeptide binding]; other site 861360006320 conserved gate region; other site 861360006321 ABC-ATPase subunit interface; other site 861360006322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360006323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006324 dimer interface [polypeptide binding]; other site 861360006325 conserved gate region; other site 861360006326 putative PBP binding loops; other site 861360006327 ABC-ATPase subunit interface; other site 861360006328 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360006329 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 861360006330 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 861360006331 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 861360006332 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 861360006333 Predicted transcriptional regulator [Transcription]; Region: COG2345 861360006334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360006335 putative DNA binding site [nucleotide binding]; other site 861360006336 putative Zn2+ binding site [ion binding]; other site 861360006337 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 861360006338 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 861360006339 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 861360006340 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 861360006341 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 861360006342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360006343 catalytic residue [active] 861360006344 dihydropteroate synthase; Region: DHPS; TIGR01496 861360006345 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 861360006346 substrate binding pocket [chemical binding]; other site 861360006347 dimer interface [polypeptide binding]; other site 861360006348 inhibitor binding site; inhibition site 861360006349 hypothetical protein; Provisional; Region: PRK14059 861360006350 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 861360006351 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 861360006352 HSP70 interaction site [polypeptide binding]; other site 861360006353 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 861360006354 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 861360006355 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 861360006356 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 861360006357 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 861360006358 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 861360006359 Ligand binding site [chemical binding]; other site 861360006360 Electron transfer flavoprotein domain; Region: ETF; pfam01012 861360006361 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 861360006362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 861360006363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 861360006364 protein binding site [polypeptide binding]; other site 861360006365 Repair protein; Region: Repair_PSII; pfam04536 861360006366 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 861360006367 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 861360006368 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 861360006369 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 861360006370 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 861360006371 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 861360006372 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 861360006373 Protein of unknown function DUF45; Region: DUF45; cl00636 861360006374 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 861360006375 Part of AAA domain; Region: AAA_19; pfam13245 861360006376 Family description; Region: UvrD_C_2; pfam13538 861360006377 HRDC domain; Region: HRDC; pfam00570 861360006378 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 861360006379 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 861360006380 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 861360006381 putative NADH binding site [chemical binding]; other site 861360006382 putative active site [active] 861360006383 nudix motif; other site 861360006384 putative metal binding site [ion binding]; other site 861360006385 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 861360006386 active site 861360006387 ATP binding site [chemical binding]; other site 861360006388 Phosphotransferase enzyme family; Region: APH; pfam01636 861360006389 substrate binding site [chemical binding]; other site 861360006390 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 861360006391 Part of AAA domain; Region: AAA_19; pfam13245 861360006392 Family description; Region: UvrD_C_2; pfam13538 861360006393 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 861360006394 Part of AAA domain; Region: AAA_19; pfam13245 861360006395 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 861360006396 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 861360006397 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 861360006398 active site 861360006399 DNA binding site [nucleotide binding] 861360006400 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 861360006401 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 861360006402 active site 861360006403 catalytic site [active] 861360006404 substrate binding site [chemical binding]; other site 861360006405 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 861360006406 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 861360006407 Walker A/P-loop; other site 861360006408 ATP binding site [chemical binding]; other site 861360006409 Q-loop/lid; other site 861360006410 ABC transporter signature motif; other site 861360006411 Walker B; other site 861360006412 D-loop; other site 861360006413 H-loop/switch region; other site 861360006414 NIL domain; Region: NIL; pfam09383 861360006415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006416 dimer interface [polypeptide binding]; other site 861360006417 conserved gate region; other site 861360006418 ABC-ATPase subunit interface; other site 861360006419 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 861360006420 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 861360006421 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 861360006422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360006423 inhibitor-cofactor binding pocket; inhibition site 861360006424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360006425 catalytic residue [active] 861360006426 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 861360006427 dimer interface [polypeptide binding]; other site 861360006428 active site 861360006429 Schiff base residues; other site 861360006430 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 861360006431 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 861360006432 active site 861360006433 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 861360006434 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 861360006435 domain interfaces; other site 861360006436 active site 861360006437 ferrochelatase; Reviewed; Region: hemH; PRK00035 861360006438 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 861360006439 C-terminal domain interface [polypeptide binding]; other site 861360006440 active site 861360006441 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 861360006442 active site 861360006443 N-terminal domain interface [polypeptide binding]; other site 861360006444 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 861360006445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360006446 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 861360006447 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 861360006448 substrate binding site [chemical binding]; other site 861360006449 active site 861360006450 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 861360006451 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 861360006452 NAD(P) binding pocket [chemical binding]; other site 861360006453 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 861360006454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360006455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360006456 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 861360006457 RNB domain; Region: RNB; pfam00773 861360006458 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 861360006459 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 861360006460 ATP binding site [chemical binding]; other site 861360006461 Mg++ binding site [ion binding]; other site 861360006462 motif III; other site 861360006463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360006464 nucleotide binding region [chemical binding]; other site 861360006465 ATP-binding site [chemical binding]; other site 861360006466 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 861360006467 DNA methylase; Region: N6_N4_Mtase; pfam01555 861360006468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360006469 S-adenosylmethionine binding site [chemical binding]; other site 861360006470 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 861360006471 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 861360006472 active site 861360006473 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 861360006474 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 861360006475 proline aminopeptidase P II; Provisional; Region: PRK10879 861360006476 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 861360006477 active site 861360006478 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 861360006479 MgtE intracellular N domain; Region: MgtE_N; smart00924 861360006480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 861360006481 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 861360006482 antiporter inner membrane protein; Provisional; Region: PRK11670 861360006483 Domain of unknown function DUF59; Region: DUF59; pfam01883 861360006484 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 861360006485 sec-independent translocase; Provisional; Region: PRK01371 861360006486 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 861360006487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360006488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360006489 DNA binding residues [nucleotide binding] 861360006490 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 861360006491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360006492 S-adenosylmethionine binding site [chemical binding]; other site 861360006493 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 861360006494 DivIVA domain; Region: DivI1A_domain; TIGR03544 861360006495 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 861360006496 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 861360006497 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 861360006498 Walker A/P-loop; other site 861360006499 ATP binding site [chemical binding]; other site 861360006500 Q-loop/lid; other site 861360006501 ABC transporter signature motif; other site 861360006502 Walker B; other site 861360006503 D-loop; other site 861360006504 H-loop/switch region; other site 861360006505 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 861360006506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360006507 substrate binding pocket [chemical binding]; other site 861360006508 membrane-bound complex binding site; other site 861360006509 hinge residues; other site 861360006510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006511 dimer interface [polypeptide binding]; other site 861360006512 conserved gate region; other site 861360006513 putative PBP binding loops; other site 861360006514 ABC-ATPase subunit interface; other site 861360006515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006516 dimer interface [polypeptide binding]; other site 861360006517 conserved gate region; other site 861360006518 putative PBP binding loops; other site 861360006519 ABC-ATPase subunit interface; other site 861360006520 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 861360006521 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 861360006522 metal binding site [ion binding]; metal-binding site 861360006523 putative dimer interface [polypeptide binding]; other site 861360006524 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 861360006525 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 861360006526 putative trimer interface [polypeptide binding]; other site 861360006527 putative CoA binding site [chemical binding]; other site 861360006528 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 861360006529 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 861360006530 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 861360006531 dimer interface [polypeptide binding]; other site 861360006532 active site 861360006533 citrylCoA binding site [chemical binding]; other site 861360006534 NADH binding [chemical binding]; other site 861360006535 cationic pore residues; other site 861360006536 oxalacetate/citrate binding site [chemical binding]; other site 861360006537 coenzyme A binding site [chemical binding]; other site 861360006538 catalytic triad [active] 861360006539 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 861360006540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360006541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360006542 homodimer interface [polypeptide binding]; other site 861360006543 catalytic residue [active] 861360006544 Ferredoxin [Energy production and conversion]; Region: COG1146 861360006545 4Fe-4S binding domain; Region: Fer4; pfam00037 861360006546 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 861360006547 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 861360006548 G1 box; other site 861360006549 putative GEF interaction site [polypeptide binding]; other site 861360006550 GTP/Mg2+ binding site [chemical binding]; other site 861360006551 Switch I region; other site 861360006552 G2 box; other site 861360006553 G3 box; other site 861360006554 Switch II region; other site 861360006555 G4 box; other site 861360006556 G5 box; other site 861360006557 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 861360006558 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 861360006559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360006560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360006561 Coenzyme A binding pocket [chemical binding]; other site 861360006562 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 861360006563 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 861360006564 ATP binding site [chemical binding]; other site 861360006565 substrate interface [chemical binding]; other site 861360006566 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 861360006567 active site residue [active] 861360006568 thiazole synthase; Reviewed; Region: thiG; PRK00208 861360006569 phosphate binding site [ion binding]; other site 861360006570 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 861360006571 thiS-thiF/thiG interaction site; other site 861360006572 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 861360006573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 861360006574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360006575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360006576 Conserved TM helix; Region: TM_helix; pfam05552 861360006577 OsmC-like protein; Region: OsmC; pfam02566 861360006578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360006579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 861360006580 YhhN-like protein; Region: YhhN; pfam07947 861360006581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360006582 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 861360006583 active site 861360006584 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 861360006585 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360006586 Coenzyme A binding pocket [chemical binding]; other site 861360006587 DinB superfamily; Region: DinB_2; pfam12867 861360006588 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 861360006589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360006590 NADH(P)-binding; Region: NAD_binding_10; pfam13460 861360006591 NAD(P) binding site [chemical binding]; other site 861360006592 active site 861360006593 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 861360006594 gating phenylalanine in ion channel; other site 861360006595 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 861360006596 tetramer interface [polypeptide binding]; other site 861360006597 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 861360006598 active site 861360006599 Mg2+/Mn2+ binding site [ion binding]; other site 861360006600 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360006601 Coenzyme A binding pocket [chemical binding]; other site 861360006602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360006603 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 861360006604 dimer interface [polypeptide binding]; other site 861360006605 putative metal binding site [ion binding]; other site 861360006606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 861360006607 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360006608 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 861360006609 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 861360006610 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 861360006611 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 861360006612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360006613 Coenzyme A binding pocket [chemical binding]; other site 861360006614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360006615 S-adenosylmethionine binding site [chemical binding]; other site 861360006616 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 861360006617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360006618 dimer interface [polypeptide binding]; other site 861360006619 active site 861360006620 acyl-CoA synthetase; Validated; Region: PRK08316 861360006621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360006622 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 861360006623 acyl-activating enzyme (AAE) consensus motif; other site 861360006624 acyl-activating enzyme (AAE) consensus motif; other site 861360006625 putative AMP binding site [chemical binding]; other site 861360006626 putative active site [active] 861360006627 putative CoA binding site [chemical binding]; other site 861360006628 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360006629 acyl-coenzyme A oxidase; Region: PLN02526 861360006630 active site 861360006631 translocation protein TolB; Provisional; Region: tolB; PRK03629 861360006632 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 861360006633 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 861360006634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360006635 RNA binding surface [nucleotide binding]; other site 861360006636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 861360006637 active site 861360006638 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 861360006639 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 861360006640 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 861360006641 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 861360006642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360006643 catalytic core [active] 861360006644 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 861360006645 conserved hypothetical protein; Region: TIGR03843 861360006646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360006647 NAD(P) binding site [chemical binding]; other site 861360006648 active site 861360006649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 861360006650 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 861360006651 Clp amino terminal domain; Region: Clp_N; pfam02861 861360006652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 861360006653 D-lactate dehydrogenase; Provisional; Region: PRK11183 861360006654 FAD binding domain; Region: FAD_binding_4; pfam01565 861360006655 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 861360006656 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 861360006657 DNA methylase; Region: N6_N4_Mtase; cl17433 861360006658 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360006659 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360006660 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360006661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 861360006662 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360006663 GTP-binding protein YchF; Reviewed; Region: PRK09601 861360006664 YchF GTPase; Region: YchF; cd01900 861360006665 G1 box; other site 861360006666 GTP/Mg2+ binding site [chemical binding]; other site 861360006667 Switch I region; other site 861360006668 G2 box; other site 861360006669 Switch II region; other site 861360006670 G3 box; other site 861360006671 G4 box; other site 861360006672 G5 box; other site 861360006673 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 861360006674 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 861360006675 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 861360006676 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 861360006677 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 861360006678 generic binding surface II; other site 861360006679 generic binding surface I; other site 861360006680 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 861360006681 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 861360006682 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 861360006683 aminotransferase AlaT; Validated; Region: PRK09265 861360006684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360006685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360006686 homodimer interface [polypeptide binding]; other site 861360006687 catalytic residue [active] 861360006688 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 861360006689 nudix motif; other site 861360006690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360006691 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 861360006692 AsnC family; Region: AsnC_trans_reg; pfam01037 861360006693 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360006694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360006695 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 861360006696 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 861360006697 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 861360006698 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 861360006699 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 861360006700 GMP synthase; Reviewed; Region: guaA; PRK00074 861360006701 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 861360006702 AMP/PPi binding site [chemical binding]; other site 861360006703 candidate oxyanion hole; other site 861360006704 catalytic triad [active] 861360006705 potential glutamine specificity residues [chemical binding]; other site 861360006706 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 861360006707 ATP Binding subdomain [chemical binding]; other site 861360006708 Ligand Binding sites [chemical binding]; other site 861360006709 Dimerization subdomain; other site 861360006710 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 861360006711 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 861360006712 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 861360006713 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 861360006714 phosphate binding site [ion binding]; other site 861360006715 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 861360006716 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 861360006717 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 861360006718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 861360006719 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 861360006720 active site 861360006721 Acyltransferase family; Region: Acyl_transf_3; pfam01757 861360006722 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 861360006723 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 861360006724 ring oligomerisation interface [polypeptide binding]; other site 861360006725 ATP/Mg binding site [chemical binding]; other site 861360006726 stacking interactions; other site 861360006727 hinge regions; other site 861360006728 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 861360006729 oligomerisation interface [polypeptide binding]; other site 861360006730 mobile loop; other site 861360006731 roof hairpin; other site 861360006732 lysine transporter; Provisional; Region: PRK10836 861360006733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360006734 S-adenosylmethionine binding site [chemical binding]; other site 861360006735 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 861360006736 carboxylate-amine ligase; Provisional; Region: PRK13517 861360006737 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 861360006738 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 861360006739 GIY-YIG motif/motif A; other site 861360006740 putative active site [active] 861360006741 putative metal binding site [ion binding]; other site 861360006742 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360006743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360006744 DNA-binding site [nucleotide binding]; DNA binding site 861360006745 FCD domain; Region: FCD; pfam07729 861360006746 cyanate transporter; Region: CynX; TIGR00896 861360006747 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360006748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360006749 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360006750 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360006751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360006752 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360006753 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360006754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360006755 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360006756 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 861360006757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360006758 Integrase core domain; Region: rve; pfam00665 861360006759 Integrase core domain; Region: rve_3; pfam13683 861360006760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360006761 Protein of unknown function DUF45; Region: DUF45; pfam01863 861360006762 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 861360006763 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 861360006764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360006765 ATP binding site [chemical binding]; other site 861360006766 putative Mg++ binding site [ion binding]; other site 861360006767 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 861360006768 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 861360006769 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 861360006770 HsdM N-terminal domain; Region: HsdM_N; pfam12161 861360006771 Methyltransferase domain; Region: Methyltransf_26; pfam13659 861360006772 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 861360006773 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 861360006774 substrate binding [chemical binding]; other site 861360006775 active site 861360006776 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 861360006777 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 861360006778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360006779 Walker A/P-loop; other site 861360006780 ATP binding site [chemical binding]; other site 861360006781 Q-loop/lid; other site 861360006782 ABC transporter signature motif; other site 861360006783 Walker B; other site 861360006784 D-loop; other site 861360006785 H-loop/switch region; other site 861360006786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360006787 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 861360006788 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360006789 Walker A/P-loop; other site 861360006790 ATP binding site [chemical binding]; other site 861360006791 Q-loop/lid; other site 861360006792 ABC transporter signature motif; other site 861360006793 Walker B; other site 861360006794 D-loop; other site 861360006795 H-loop/switch region; other site 861360006796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360006797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 861360006798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006799 dimer interface [polypeptide binding]; other site 861360006800 conserved gate region; other site 861360006801 putative PBP binding loops; other site 861360006802 ABC-ATPase subunit interface; other site 861360006803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360006804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360006805 dimer interface [polypeptide binding]; other site 861360006806 conserved gate region; other site 861360006807 putative PBP binding loops; other site 861360006808 ABC-ATPase subunit interface; other site 861360006809 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 861360006810 substrate binding site [chemical binding]; other site 861360006811 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 861360006812 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360006813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360006814 DNA binding site [nucleotide binding] 861360006815 domain linker motif; other site 861360006816 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 861360006817 putative dimerization interface [polypeptide binding]; other site 861360006818 putative ligand binding site [chemical binding]; other site 861360006819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360006820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360006821 DNA binding site [nucleotide binding] 861360006822 domain linker motif; other site 861360006823 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 861360006824 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 861360006825 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 861360006826 substrate binding [chemical binding]; other site 861360006827 active site 861360006828 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 861360006829 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 861360006830 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 861360006831 putative substrate binding site [chemical binding]; other site 861360006832 putative ATP binding site [chemical binding]; other site 861360006833 galactoside permease; Reviewed; Region: lacY; PRK09528 861360006834 UGMP family protein; Validated; Region: PRK09604 861360006835 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 861360006836 T4 bacteriophage base plate protein; Region: T4_baseplate; pfam12322 861360006837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360006838 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 861360006839 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360006840 Coenzyme A binding pocket [chemical binding]; other site 861360006841 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 861360006842 Glycoprotease family; Region: Peptidase_M22; pfam00814 861360006843 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 861360006844 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 861360006845 alanine racemase; Reviewed; Region: alr; PRK00053 861360006846 active site 861360006847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360006848 dimer interface [polypeptide binding]; other site 861360006849 substrate binding site [chemical binding]; other site 861360006850 catalytic residues [active] 861360006851 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 861360006852 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 861360006853 pantothenate kinase; Provisional; Region: PRK05439 861360006854 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 861360006855 ATP-binding site [chemical binding]; other site 861360006856 CoA-binding site [chemical binding]; other site 861360006857 Mg2+-binding site [ion binding]; other site 861360006858 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 861360006859 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 861360006860 glutaminase active site [active] 861360006861 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 861360006862 dimer interface [polypeptide binding]; other site 861360006863 active site 861360006864 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 861360006865 dimer interface [polypeptide binding]; other site 861360006866 active site 861360006867 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 861360006868 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 861360006869 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 861360006870 putative substrate binding site [chemical binding]; other site 861360006871 putative ATP binding site [chemical binding]; other site 861360006872 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 861360006873 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 861360006874 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 861360006875 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 861360006876 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 861360006877 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 861360006878 active site 861360006879 substrate binding site [chemical binding]; other site 861360006880 metal binding site [ion binding]; metal-binding site 861360006881 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 861360006882 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 861360006883 23S rRNA interface [nucleotide binding]; other site 861360006884 L3 interface [polypeptide binding]; other site 861360006885 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 861360006886 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 861360006887 dimerization interface 3.5A [polypeptide binding]; other site 861360006888 active site 861360006889 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 861360006890 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 861360006891 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 861360006892 alphaNTD - beta interaction site [polypeptide binding]; other site 861360006893 alphaNTD homodimer interface [polypeptide binding]; other site 861360006894 alphaNTD - beta' interaction site [polypeptide binding]; other site 861360006895 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 861360006896 30S ribosomal protein S11; Validated; Region: PRK05309 861360006897 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 861360006898 30S ribosomal protein S13; Region: bact_S13; TIGR03631 861360006899 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 861360006900 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 861360006901 rRNA binding site [nucleotide binding]; other site 861360006902 predicted 30S ribosome binding site; other site 861360006903 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 861360006904 active site 861360006905 adenylate kinase; Reviewed; Region: adk; PRK00279 861360006906 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 861360006907 AMP-binding site [chemical binding]; other site 861360006908 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 861360006909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 861360006910 SecY translocase; Region: SecY; pfam00344 861360006911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 861360006912 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 861360006913 23S rRNA binding site [nucleotide binding]; other site 861360006914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 861360006915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 861360006916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 861360006917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 861360006918 5S rRNA interface [nucleotide binding]; other site 861360006919 L27 interface [polypeptide binding]; other site 861360006920 23S rRNA interface [nucleotide binding]; other site 861360006921 L5 interface [polypeptide binding]; other site 861360006922 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 861360006923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 861360006924 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 861360006925 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 861360006926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 861360006927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 861360006928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 861360006929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 861360006930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 861360006931 RNA binding site [nucleotide binding]; other site 861360006932 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 861360006933 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 861360006934 putative catalytic site [active] 861360006935 putative metal binding site [ion binding]; other site 861360006936 putative phosphate binding site [ion binding]; other site 861360006937 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 861360006938 putative dimer interface [polypeptide binding]; other site 861360006939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360006940 Helix-turn-helix domain; Region: HTH_18; pfam12833 861360006941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360006942 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 861360006943 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 861360006944 putative translocon interaction site; other site 861360006945 23S rRNA interface [nucleotide binding]; other site 861360006946 signal recognition particle (SRP54) interaction site; other site 861360006947 L23 interface [polypeptide binding]; other site 861360006948 trigger factor interaction site; other site 861360006949 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 861360006950 23S rRNA interface [nucleotide binding]; other site 861360006951 5S rRNA interface [nucleotide binding]; other site 861360006952 putative antibiotic binding site [chemical binding]; other site 861360006953 L25 interface [polypeptide binding]; other site 861360006954 L27 interface [polypeptide binding]; other site 861360006955 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 861360006956 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 861360006957 G-X-X-G motif; other site 861360006958 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 861360006959 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 861360006960 putative translocon binding site; other site 861360006961 protein-rRNA interface [nucleotide binding]; other site 861360006962 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 861360006963 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 861360006964 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 861360006965 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 861360006966 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 861360006967 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 861360006968 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 861360006969 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 861360006970 elongation factor Tu; Reviewed; Region: PRK00049 861360006971 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 861360006972 G1 box; other site 861360006973 GEF interaction site [polypeptide binding]; other site 861360006974 GTP/Mg2+ binding site [chemical binding]; other site 861360006975 Switch I region; other site 861360006976 G2 box; other site 861360006977 G3 box; other site 861360006978 Switch II region; other site 861360006979 G4 box; other site 861360006980 G5 box; other site 861360006981 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 861360006982 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 861360006983 Antibiotic Binding Site [chemical binding]; other site 861360006984 elongation factor G; Reviewed; Region: PRK00007 861360006985 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 861360006986 G1 box; other site 861360006987 putative GEF interaction site [polypeptide binding]; other site 861360006988 GTP/Mg2+ binding site [chemical binding]; other site 861360006989 Switch I region; other site 861360006990 G2 box; other site 861360006991 G3 box; other site 861360006992 Switch II region; other site 861360006993 G4 box; other site 861360006994 G5 box; other site 861360006995 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 861360006996 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 861360006997 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 861360006998 30S ribosomal protein S7; Validated; Region: PRK05302 861360006999 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 861360007000 S17 interaction site [polypeptide binding]; other site 861360007001 S8 interaction site; other site 861360007002 16S rRNA interaction site [nucleotide binding]; other site 861360007003 streptomycin interaction site [chemical binding]; other site 861360007004 23S rRNA interaction site [nucleotide binding]; other site 861360007005 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 861360007006 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 861360007007 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 861360007008 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 861360007009 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 861360007010 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 861360007011 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 861360007012 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 861360007013 G-loop; other site 861360007014 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 861360007015 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 861360007016 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 861360007017 DNA binding site [nucleotide binding] 861360007018 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 861360007019 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 861360007020 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 861360007021 RPB10 interaction site [polypeptide binding]; other site 861360007022 RPB1 interaction site [polypeptide binding]; other site 861360007023 RPB11 interaction site [polypeptide binding]; other site 861360007024 RPB3 interaction site [polypeptide binding]; other site 861360007025 RPB12 interaction site [polypeptide binding]; other site 861360007026 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 861360007027 putative deacylase active site [active] 861360007028 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 861360007029 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 861360007030 core dimer interface [polypeptide binding]; other site 861360007031 peripheral dimer interface [polypeptide binding]; other site 861360007032 L10 interface [polypeptide binding]; other site 861360007033 L11 interface [polypeptide binding]; other site 861360007034 putative EF-Tu interaction site [polypeptide binding]; other site 861360007035 putative EF-G interaction site [polypeptide binding]; other site 861360007036 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 861360007037 23S rRNA interface [nucleotide binding]; other site 861360007038 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 861360007039 mRNA/rRNA interface [nucleotide binding]; other site 861360007040 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 861360007041 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 861360007042 23S rRNA interface [nucleotide binding]; other site 861360007043 putative thiostrepton binding site; other site 861360007044 L7/L12 interface [polypeptide binding]; other site 861360007045 L25 interface [polypeptide binding]; other site 861360007046 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 861360007047 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 861360007048 putative homodimer interface [polypeptide binding]; other site 861360007049 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 861360007050 heterodimer interface [polypeptide binding]; other site 861360007051 homodimer interface [polypeptide binding]; other site 861360007052 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 861360007053 aspartate aminotransferase; Provisional; Region: PRK05764 861360007054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360007055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007056 homodimer interface [polypeptide binding]; other site 861360007057 catalytic residue [active] 861360007058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360007060 active site 861360007061 phosphorylation site [posttranslational modification] 861360007062 intermolecular recognition site; other site 861360007063 dimerization interface [polypeptide binding]; other site 861360007064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360007065 dimerization interface [polypeptide binding]; other site 861360007066 DNA binding residues [nucleotide binding] 861360007067 PspC domain; Region: PspC; pfam04024 861360007068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360007069 ATP binding site [chemical binding]; other site 861360007070 Mg2+ binding site [ion binding]; other site 861360007071 G-X-G motif; other site 861360007072 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 861360007073 PspC domain; Region: PspC; pfam04024 861360007074 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 861360007075 phosphofructokinase; Region: PFK_mixed; TIGR02483 861360007076 active site 861360007077 ADP/pyrophosphate binding site [chemical binding]; other site 861360007078 dimerization interface [polypeptide binding]; other site 861360007079 allosteric effector site; other site 861360007080 fructose-1,6-bisphosphate binding site; other site 861360007081 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 861360007082 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 861360007083 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 861360007084 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 861360007085 heme-binding site [chemical binding]; other site 861360007086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 861360007087 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 861360007088 DNA binding site [nucleotide binding] 861360007089 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 861360007090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360007091 Coenzyme A binding pocket [chemical binding]; other site 861360007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360007093 Coenzyme A binding pocket [chemical binding]; other site 861360007094 polyphosphate kinase; Provisional; Region: PRK05443 861360007095 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 861360007096 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 861360007097 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 861360007098 putative domain interface [polypeptide binding]; other site 861360007099 putative active site [active] 861360007100 catalytic site [active] 861360007101 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 861360007102 putative domain interface [polypeptide binding]; other site 861360007103 putative active site [active] 861360007104 catalytic site [active] 861360007105 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 861360007106 active site 861360007107 Ap6A binding site [chemical binding]; other site 861360007108 nudix motif; other site 861360007109 metal binding site [ion binding]; metal-binding site 861360007110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360007111 catalytic core [active] 861360007112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360007113 Coenzyme A binding pocket [chemical binding]; other site 861360007114 thymidylate synthase; Reviewed; Region: thyA; PRK01827 861360007115 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 861360007116 dimerization interface [polypeptide binding]; other site 861360007117 active site 861360007118 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 861360007119 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 861360007120 folate binding site [chemical binding]; other site 861360007121 NADP+ binding site [chemical binding]; other site 861360007122 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 861360007123 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 861360007124 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360007125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360007126 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 861360007127 FAD binding domain; Region: FAD_binding_4; pfam01565 861360007128 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 861360007129 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 861360007130 active site 861360007131 catalytic site [active] 861360007132 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 861360007133 active site 861360007134 catalytic site [active] 861360007135 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 861360007136 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 861360007137 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 861360007138 synthetase active site [active] 861360007139 NTP binding site [chemical binding]; other site 861360007140 metal binding site [ion binding]; metal-binding site 861360007141 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 861360007142 ThiC-associated domain; Region: ThiC-associated; pfam13667 861360007143 ThiC family; Region: ThiC; pfam01964 861360007144 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 861360007145 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 861360007146 ATP binding site [chemical binding]; other site 861360007147 Mg++ binding site [ion binding]; other site 861360007148 motif III; other site 861360007149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360007150 nucleotide binding region [chemical binding]; other site 861360007151 ATP-binding site [chemical binding]; other site 861360007152 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 861360007153 putative RNA binding site [nucleotide binding]; other site 861360007154 cystathionine gamma-synthase; Provisional; Region: PRK07811 861360007155 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 861360007156 homodimer interface [polypeptide binding]; other site 861360007157 substrate-cofactor binding pocket; other site 861360007158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007159 catalytic residue [active] 861360007160 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 861360007161 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 861360007162 dimer interface [polypeptide binding]; other site 861360007163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007164 catalytic residue [active] 861360007165 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 861360007166 minor groove reading motif; other site 861360007167 helix-hairpin-helix signature motif; other site 861360007168 substrate binding pocket [chemical binding]; other site 861360007169 active site 861360007170 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 861360007171 catalytic residues [active] 861360007172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360007173 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360007174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 861360007175 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 861360007176 heat shock protein HtpX; Provisional; Region: PRK03072 861360007177 Predicted permeases [General function prediction only]; Region: RarD; COG2962 861360007178 EamA-like transporter family; Region: EamA; cl17759 861360007179 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 861360007180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360007181 inhibitor-cofactor binding pocket; inhibition site 861360007182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007183 catalytic residue [active] 861360007184 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 861360007185 Na2 binding site [ion binding]; other site 861360007186 putative substrate binding site 1 [chemical binding]; other site 861360007187 Na binding site 1 [ion binding]; other site 861360007188 putative substrate binding site 2 [chemical binding]; other site 861360007189 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 861360007190 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 861360007191 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 861360007192 nucleotide binding site/active site [active] 861360007193 HIT family signature motif; other site 861360007194 catalytic residue [active] 861360007195 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 861360007196 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 861360007197 substrate binding pocket [chemical binding]; other site 861360007198 chain length determination region; other site 861360007199 substrate-Mg2+ binding site; other site 861360007200 catalytic residues [active] 861360007201 aspartate-rich region 1; other site 861360007202 active site lid residues [active] 861360007203 aspartate-rich region 2; other site 861360007204 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 861360007205 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 861360007206 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360007207 substrate binding pocket [chemical binding]; other site 861360007208 membrane-bound complex binding site; other site 861360007209 hinge residues; other site 861360007210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360007211 dimer interface [polypeptide binding]; other site 861360007212 conserved gate region; other site 861360007213 putative PBP binding loops; other site 861360007214 ABC-ATPase subunit interface; other site 861360007215 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 861360007216 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 861360007217 Walker A/P-loop; other site 861360007218 ATP binding site [chemical binding]; other site 861360007219 Q-loop/lid; other site 861360007220 ABC transporter signature motif; other site 861360007221 Walker B; other site 861360007222 D-loop; other site 861360007223 H-loop/switch region; other site 861360007224 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 861360007225 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 861360007226 dimer interface [polypeptide binding]; other site 861360007227 tetramer interface [polypeptide binding]; other site 861360007228 PYR/PP interface [polypeptide binding]; other site 861360007229 TPP binding site [chemical binding]; other site 861360007230 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 861360007231 TPP-binding site; other site 861360007232 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 861360007233 O-succinylbenzoate synthase; Provisional; Region: PRK02901 861360007234 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 861360007235 active site 861360007236 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 861360007237 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 861360007238 active site 861360007239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360007240 E3 interaction surface; other site 861360007241 lipoyl attachment site [posttranslational modification]; other site 861360007242 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 861360007243 e3 binding domain; Region: E3_binding; pfam02817 861360007244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 861360007245 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 861360007246 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 861360007247 alpha subunit interface [polypeptide binding]; other site 861360007248 TPP binding site [chemical binding]; other site 861360007249 heterodimer interface [polypeptide binding]; other site 861360007250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360007251 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 861360007252 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 861360007253 tetramer interface [polypeptide binding]; other site 861360007254 TPP-binding site [chemical binding]; other site 861360007255 heterodimer interface [polypeptide binding]; other site 861360007256 phosphorylation loop region [posttranslational modification] 861360007257 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360007258 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 861360007259 AsnC family; Region: AsnC_trans_reg; pfam01037 861360007260 enoyl-CoA hydratase; Provisional; Region: PRK06688 861360007261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360007262 substrate binding site [chemical binding]; other site 861360007263 oxyanion hole (OAH) forming residues; other site 861360007264 trimer interface [polypeptide binding]; other site 861360007265 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 861360007266 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 861360007267 FAD binding pocket [chemical binding]; other site 861360007268 FAD binding motif [chemical binding]; other site 861360007269 phosphate binding motif [ion binding]; other site 861360007270 beta-alpha-beta structure motif; other site 861360007271 NAD(p) ribose binding residues [chemical binding]; other site 861360007272 NAD binding pocket [chemical binding]; other site 861360007273 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 861360007274 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 861360007275 catalytic loop [active] 861360007276 iron binding site [ion binding]; other site 861360007277 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 861360007278 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 861360007279 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 861360007280 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 861360007281 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 861360007282 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 861360007283 Predicted membrane protein [Function unknown]; Region: COG2259 861360007284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 861360007285 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 861360007286 Walker A/P-loop; other site 861360007287 ATP binding site [chemical binding]; other site 861360007288 Q-loop/lid; other site 861360007289 ABC transporter signature motif; other site 861360007290 Walker B; other site 861360007291 D-loop; other site 861360007292 H-loop/switch region; other site 861360007293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360007294 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 861360007295 substrate binding pocket [chemical binding]; other site 861360007296 membrane-bound complex binding site; other site 861360007297 hinge residues; other site 861360007298 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 861360007299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360007300 dimer interface [polypeptide binding]; other site 861360007301 conserved gate region; other site 861360007302 putative PBP binding loops; other site 861360007303 ABC-ATPase subunit interface; other site 861360007304 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 861360007305 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360007306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 861360007307 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 861360007308 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 861360007309 CoenzymeA binding site [chemical binding]; other site 861360007310 subunit interaction site [polypeptide binding]; other site 861360007311 PHB binding site; other site 861360007312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360007313 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 861360007314 acyl-activating enzyme (AAE) consensus motif; other site 861360007315 AMP binding site [chemical binding]; other site 861360007316 active site 861360007317 CoA binding site [chemical binding]; other site 861360007318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360007319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360007320 Translation machinery associated TMA7; Region: TMA7; pfam09072 861360007321 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 861360007322 active site 861360007323 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 861360007324 Ca binding site [ion binding]; other site 861360007325 catalytic site [active] 861360007326 Aamy_C domain; Region: Aamy_C; smart00632 861360007327 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 861360007328 starch-binding site 2 [chemical binding]; other site 861360007329 starch-binding site 1 [chemical binding]; other site 861360007330 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 861360007331 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 861360007332 substrate binding site [chemical binding]; other site 861360007333 dimer interface [polypeptide binding]; other site 861360007334 NADP binding site [chemical binding]; other site 861360007335 catalytic residues [active] 861360007336 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 861360007337 active site 2 [active] 861360007338 active site 1 [active] 861360007339 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 861360007340 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 861360007341 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 861360007342 ATP binding site [chemical binding]; other site 861360007343 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 861360007344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 861360007345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 861360007346 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 861360007347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360007348 substrate binding site [chemical binding]; other site 861360007349 oxyanion hole (OAH) forming residues; other site 861360007350 trimer interface [polypeptide binding]; other site 861360007351 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 861360007352 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360007353 dimer interface [polypeptide binding]; other site 861360007354 active site 861360007355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007356 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360007357 putative substrate translocation pore; other site 861360007358 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 861360007359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360007360 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 861360007361 substrate binding site [chemical binding]; other site 861360007362 oxyanion hole (OAH) forming residues; other site 861360007363 trimer interface [polypeptide binding]; other site 861360007364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360007365 acyl-activating enzyme (AAE) consensus motif; other site 861360007366 AMP binding site [chemical binding]; other site 861360007367 active site 861360007368 CoA binding site [chemical binding]; other site 861360007369 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 861360007370 UbiA prenyltransferase family; Region: UbiA; pfam01040 861360007371 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 861360007372 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 861360007373 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 861360007374 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 861360007375 ResB-like family; Region: ResB; pfam05140 861360007376 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 861360007377 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 861360007378 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 861360007379 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 861360007380 catalytic residues [active] 861360007381 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360007382 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 861360007383 catalytic core [active] 861360007384 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 861360007385 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 861360007386 CoA binding domain; Region: CoA_binding; smart00881 861360007387 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 861360007388 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 861360007389 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 861360007390 DNA binding domain, excisionase family; Region: excise; TIGR01764 861360007391 glutamate dehydrogenase; Provisional; Region: PRK09414 861360007392 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 861360007393 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 861360007394 NAD(P) binding site [chemical binding]; other site 861360007395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360007396 dimerization interface [polypeptide binding]; other site 861360007397 putative DNA binding site [nucleotide binding]; other site 861360007398 putative Zn2+ binding site [ion binding]; other site 861360007399 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 861360007400 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 861360007401 active site 861360007402 Zn binding site [ion binding]; other site 861360007403 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 861360007404 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 861360007405 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 861360007406 TrkA-N domain; Region: TrkA_N; pfam02254 861360007407 TrkA-C domain; Region: TrkA_C; pfam02080 861360007408 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 861360007409 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 861360007410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 861360007411 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 861360007412 DNA interaction; other site 861360007413 Metal-binding active site; metal-binding site 861360007414 exopolyphosphatase; Region: exo_poly_only; TIGR03706 861360007415 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 861360007416 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 861360007417 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 861360007418 active site 861360007419 interdomain interaction site; other site 861360007420 putative metal-binding site [ion binding]; other site 861360007421 nucleotide binding site [chemical binding]; other site 861360007422 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 861360007423 domain I; other site 861360007424 phosphate binding site [ion binding]; other site 861360007425 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 861360007426 domain II; other site 861360007427 domain III; other site 861360007428 nucleotide binding site [chemical binding]; other site 861360007429 DNA binding groove [nucleotide binding] 861360007430 catalytic site [active] 861360007431 domain IV; other site 861360007432 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 861360007433 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 861360007434 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 861360007435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360007436 dimerization interface [polypeptide binding]; other site 861360007437 putative DNA binding site [nucleotide binding]; other site 861360007438 putative Zn2+ binding site [ion binding]; other site 861360007439 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 861360007440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360007441 S-adenosylmethionine binding site [chemical binding]; other site 861360007442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360007443 Coenzyme A binding pocket [chemical binding]; other site 861360007444 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 861360007445 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 861360007446 active site residue [active] 861360007447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 861360007448 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 861360007449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360007450 ATP binding site [chemical binding]; other site 861360007451 putative Mg++ binding site [ion binding]; other site 861360007452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360007453 nucleotide binding region [chemical binding]; other site 861360007454 ATP-binding site [chemical binding]; other site 861360007455 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 861360007456 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 861360007457 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 861360007458 catalytic residues [active] 861360007459 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 861360007460 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 861360007461 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 861360007462 Type II/IV secretion system protein; Region: T2SE; pfam00437 861360007463 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 861360007464 Walker A motif; other site 861360007465 hexamer interface [polypeptide binding]; other site 861360007466 ATP binding site [chemical binding]; other site 861360007467 Walker B motif; other site 861360007468 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 861360007469 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 861360007470 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 861360007471 active site 861360007472 DNA binding site [nucleotide binding] 861360007473 catalytic site [active] 861360007474 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 861360007475 putative active site [active] 861360007476 putative CoA binding site [chemical binding]; other site 861360007477 nudix motif; other site 861360007478 metal binding site [ion binding]; metal-binding site 861360007479 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 861360007480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 861360007481 minor groove reading motif; other site 861360007482 helix-hairpin-helix signature motif; other site 861360007483 substrate binding pocket [chemical binding]; other site 861360007484 active site 861360007485 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 861360007486 acetyl-CoA synthetase; Provisional; Region: PRK00174 861360007487 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 861360007488 active site 861360007489 CoA binding site [chemical binding]; other site 861360007490 acyl-activating enzyme (AAE) consensus motif; other site 861360007491 AMP binding site [chemical binding]; other site 861360007492 acetate binding site [chemical binding]; other site 861360007493 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 861360007494 Dehydroquinase class II; Region: DHquinase_II; pfam01220 861360007495 active site 861360007496 trimer interface [polypeptide binding]; other site 861360007497 dimer interface [polypeptide binding]; other site 861360007498 Colicin V production protein; Region: Colicin_V; pfam02674 861360007499 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 861360007500 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 861360007501 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 861360007502 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 861360007503 ligand binding site [chemical binding]; other site 861360007504 flexible hinge region; other site 861360007505 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 861360007506 putative switch regulator; other site 861360007507 non-specific DNA interactions [nucleotide binding]; other site 861360007508 DNA binding site [nucleotide binding] 861360007509 sequence specific DNA binding site [nucleotide binding]; other site 861360007510 putative cAMP binding site [chemical binding]; other site 861360007511 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 861360007512 nudix motif; other site 861360007513 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 861360007514 homotrimer interaction site [polypeptide binding]; other site 861360007515 putative active site [active] 861360007516 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 861360007517 Transglycosylase; Region: Transgly; pfam00912 861360007518 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 861360007519 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 861360007520 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360007521 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 861360007522 active site 861360007523 metal binding site [ion binding]; metal-binding site 861360007524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360007525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360007526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360007527 Walker A/P-loop; other site 861360007528 ATP binding site [chemical binding]; other site 861360007529 Q-loop/lid; other site 861360007530 ABC transporter signature motif; other site 861360007531 Walker B; other site 861360007532 D-loop; other site 861360007533 H-loop/switch region; other site 861360007534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360007535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360007536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360007537 Walker A/P-loop; other site 861360007538 ATP binding site [chemical binding]; other site 861360007539 Q-loop/lid; other site 861360007540 ABC transporter signature motif; other site 861360007541 Walker B; other site 861360007542 D-loop; other site 861360007543 H-loop/switch region; other site 861360007544 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 861360007545 ATP binding site [chemical binding]; other site 861360007546 active site 861360007547 substrate binding site [chemical binding]; other site 861360007548 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 861360007549 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 861360007550 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 861360007551 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 861360007552 amidophosphoribosyltransferase; Provisional; Region: PRK07847 861360007553 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 861360007554 active site 861360007555 tetramer interface [polypeptide binding]; other site 861360007556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 861360007557 active site 861360007558 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 861360007559 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 861360007560 dimerization interface [polypeptide binding]; other site 861360007561 putative ATP binding site [chemical binding]; other site 861360007562 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 861360007563 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 861360007564 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 861360007565 Septum formation; Region: Septum_form; pfam13845 861360007566 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 861360007567 Clp amino terminal domain; Region: Clp_N; pfam02861 861360007568 Clp amino terminal domain; Region: Clp_N; pfam02861 861360007569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360007570 Walker A motif; other site 861360007571 ATP binding site [chemical binding]; other site 861360007572 Walker B motif; other site 861360007573 arginine finger; other site 861360007574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360007575 Walker A motif; other site 861360007576 ATP binding site [chemical binding]; other site 861360007577 Walker B motif; other site 861360007578 arginine finger; other site 861360007579 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 861360007580 Protein of unknown function (DUF664); Region: DUF664; pfam04978 861360007581 DinB superfamily; Region: DinB_2; pfam12867 861360007582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360007583 Coenzyme A binding pocket [chemical binding]; other site 861360007584 Integral membrane protein TerC family; Region: TerC; cl10468 861360007585 hypothetical protein; Provisional; Region: PRK11770 861360007586 Domain of unknown function (DUF307); Region: DUF307; pfam03733 861360007587 Domain of unknown function (DUF307); Region: DUF307; pfam03733 861360007588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360007589 S-adenosylmethionine binding site [chemical binding]; other site 861360007590 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360007591 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360007592 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 861360007593 DNA binding residues [nucleotide binding] 861360007594 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 861360007595 putative dimer interface [polypeptide binding]; other site 861360007596 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 861360007597 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 861360007598 HSP70 interaction site [polypeptide binding]; other site 861360007599 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 861360007600 dimer interface [polypeptide binding]; other site 861360007601 GrpE; Region: GrpE; pfam01025 861360007602 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 861360007603 dimer interface [polypeptide binding]; other site 861360007604 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 861360007605 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 861360007606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360007607 nucleotide binding site [chemical binding]; other site 861360007608 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 861360007609 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 861360007610 DEAD-like helicases superfamily; Region: DEXDc; smart00487 861360007611 ATP binding site [chemical binding]; other site 861360007612 Mg++ binding site [ion binding]; other site 861360007613 motif III; other site 861360007614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360007615 nucleotide binding region [chemical binding]; other site 861360007616 ATP-binding site [chemical binding]; other site 861360007617 MMPL family; Region: MMPL; pfam03176 861360007618 MMPL family; Region: MMPL; pfam03176 861360007619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360007620 MarR family; Region: MarR_2; cl17246 861360007621 LysE type translocator; Region: LysE; cl00565 861360007622 Low molecular weight phosphatase family; Region: LMWPc; cd00115 861360007623 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 861360007624 active site 861360007625 hypothetical protein; Provisional; Region: PRK06547 861360007626 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 861360007627 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 861360007628 chorismate binding enzyme; Region: Chorismate_bind; cl10555 861360007629 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 861360007630 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 861360007631 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 861360007632 putative active site [active] 861360007633 catalytic site [active] 861360007634 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 861360007635 putative active site [active] 861360007636 catalytic site [active] 861360007637 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 861360007638 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 861360007639 homodimer interface [polypeptide binding]; other site 861360007640 substrate-cofactor binding pocket; other site 861360007641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007642 catalytic residue [active] 861360007643 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 861360007644 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 861360007645 Walker A/P-loop; other site 861360007646 ATP binding site [chemical binding]; other site 861360007647 Q-loop/lid; other site 861360007648 ABC transporter signature motif; other site 861360007649 Walker B; other site 861360007650 D-loop; other site 861360007651 H-loop/switch region; other site 861360007652 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 861360007653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 861360007654 Q-loop/lid; other site 861360007655 ABC transporter signature motif; other site 861360007656 Walker B; other site 861360007657 D-loop; other site 861360007658 H-loop/switch region; other site 861360007659 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 861360007660 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 861360007661 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 861360007662 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 861360007663 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 861360007664 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 861360007665 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 861360007666 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 861360007667 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 861360007668 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 861360007669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 861360007670 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 861360007671 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 861360007672 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 861360007673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007674 putative substrate translocation pore; other site 861360007675 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 861360007676 trimer interface [polypeptide binding]; other site 861360007677 active site 861360007678 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 861360007679 fumarate hydratase; Provisional; Region: PRK15389 861360007680 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 861360007681 Fumarase C-terminus; Region: Fumerase_C; pfam05683 861360007682 Predicted permeases [General function prediction only]; Region: COG0679 861360007683 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 861360007684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360007685 substrate binding pocket [chemical binding]; other site 861360007686 membrane-bound complex binding site; other site 861360007687 hinge residues; other site 861360007688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360007689 dimer interface [polypeptide binding]; other site 861360007690 conserved gate region; other site 861360007691 putative PBP binding loops; other site 861360007692 ABC-ATPase subunit interface; other site 861360007693 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 861360007694 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 861360007695 Walker A/P-loop; other site 861360007696 ATP binding site [chemical binding]; other site 861360007697 Q-loop/lid; other site 861360007698 ABC transporter signature motif; other site 861360007699 Walker B; other site 861360007700 D-loop; other site 861360007701 H-loop/switch region; other site 861360007702 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 861360007703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 861360007704 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360007705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007706 putative substrate translocation pore; other site 861360007707 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 861360007708 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 861360007709 NHL repeat; Region: NHL; pfam01436 861360007710 Strictosidine synthase; Region: Str_synth; pfam03088 861360007711 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 861360007712 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 861360007713 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 861360007714 Protein of unknown function (DUF461); Region: DUF461; pfam04314 861360007715 CopC domain; Region: CopC; pfam04234 861360007716 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 861360007717 IHF dimer interface [polypeptide binding]; other site 861360007718 IHF - DNA interface [nucleotide binding]; other site 861360007719 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 861360007720 IHF dimer interface [polypeptide binding]; other site 861360007721 IHF - DNA interface [nucleotide binding]; other site 861360007722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360007723 NAD(P) binding site [chemical binding]; other site 861360007724 active site 861360007725 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 861360007726 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 861360007727 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 861360007728 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 861360007729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360007730 MarR family; Region: MarR_2; cl17246 861360007731 MarR family; Region: MarR_2; cl17246 861360007732 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 861360007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360007734 dimer interface [polypeptide binding]; other site 861360007735 conserved gate region; other site 861360007736 putative PBP binding loops; other site 861360007737 ABC-ATPase subunit interface; other site 861360007738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360007739 dimer interface [polypeptide binding]; other site 861360007740 conserved gate region; other site 861360007741 putative PBP binding loops; other site 861360007742 ABC-ATPase subunit interface; other site 861360007743 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 861360007744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360007745 Walker A/P-loop; other site 861360007746 ATP binding site [chemical binding]; other site 861360007747 Q-loop/lid; other site 861360007748 ABC transporter signature motif; other site 861360007749 Walker B; other site 861360007750 D-loop; other site 861360007751 H-loop/switch region; other site 861360007752 TOBE domain; Region: TOBE_2; pfam08402 861360007753 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 861360007754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 861360007755 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 861360007756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 861360007757 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 861360007758 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 861360007759 putative DNA binding site [nucleotide binding]; other site 861360007760 putative Zn2+ binding site [ion binding]; other site 861360007761 AsnC family; Region: AsnC_trans_reg; pfam01037 861360007762 hypothetical protein; Provisional; Region: PRK06541 861360007763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360007764 inhibitor-cofactor binding pocket; inhibition site 861360007765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007766 catalytic residue [active] 861360007767 Domain of unknown function (DUF955); Region: DUF955; cl01076 861360007768 Domain of unknown function (DUF222); Region: DUF222; pfam02720 861360007769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360007770 active site 861360007771 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 861360007772 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 861360007773 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 861360007774 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 861360007775 tetrameric interface [polypeptide binding]; other site 861360007776 NAD binding site [chemical binding]; other site 861360007777 catalytic residues [active] 861360007778 hypothetical protein; Provisional; Region: PRK06062 861360007779 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 861360007780 inhibitor-cofactor binding pocket; inhibition site 861360007781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007782 catalytic residue [active] 861360007783 FAD binding domain; Region: FAD_binding_4; pfam01565 861360007784 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 861360007785 Htaa; Region: HtaA; pfam04213 861360007786 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 861360007787 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 861360007788 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 861360007789 shikimate binding site; other site 861360007790 NAD(P) binding site [chemical binding]; other site 861360007791 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 861360007792 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360007793 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 861360007794 NAD(P) binding site [chemical binding]; other site 861360007795 catalytic residues [active] 861360007796 Amino acid permease; Region: AA_permease; pfam00324 861360007797 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 861360007798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 861360007799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360007800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360007801 tyramine oxidase; Provisional; Region: tynA; PRK11504 861360007802 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 861360007803 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 861360007804 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 861360007805 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 861360007806 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 861360007807 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 861360007808 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 861360007809 tetrameric interface [polypeptide binding]; other site 861360007810 NAD binding site [chemical binding]; other site 861360007811 catalytic residues [active] 861360007812 substrate binding site [chemical binding]; other site 861360007813 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 861360007814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360007815 intersubunit interface [polypeptide binding]; other site 861360007816 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 861360007817 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360007818 YibE/F-like protein; Region: YibE_F; pfam07907 861360007819 CAAX protease self-immunity; Region: Abi; pfam02517 861360007820 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 861360007821 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 861360007822 active site 861360007823 FMN binding site [chemical binding]; other site 861360007824 substrate binding site [chemical binding]; other site 861360007825 homotetramer interface [polypeptide binding]; other site 861360007826 catalytic residue [active] 861360007827 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 861360007828 MgtE intracellular N domain; Region: MgtE_N; pfam03448 861360007829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 861360007830 Divalent cation transporter; Region: MgtE; cl00786 861360007831 Divalent cation transporter; Region: MgtE; cl00786 861360007832 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 861360007833 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 861360007834 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 861360007835 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 861360007836 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 861360007837 dimer interface [polypeptide binding]; other site 861360007838 active site 861360007839 glycine-pyridoxal phosphate binding site [chemical binding]; other site 861360007840 folate binding site [chemical binding]; other site 861360007841 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 861360007842 lipoyl attachment site [posttranslational modification]; other site 861360007843 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 861360007844 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 861360007845 glycine dehydrogenase; Provisional; Region: PRK05367 861360007846 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 861360007847 tetramer interface [polypeptide binding]; other site 861360007848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007849 catalytic residue [active] 861360007850 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 861360007851 tetramer interface [polypeptide binding]; other site 861360007852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360007853 catalytic residue [active] 861360007854 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 861360007855 active site 861360007856 catalytic triad [active] 861360007857 oxyanion hole [active] 861360007858 Beta-lactamase; Region: Beta-lactamase; pfam00144 861360007859 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 861360007860 amino acid transporter; Region: 2A0306; TIGR00909 861360007861 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 861360007862 RNA/DNA hybrid binding site [nucleotide binding]; other site 861360007863 active site 861360007864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 861360007865 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 861360007866 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 861360007867 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 861360007868 putative dimer interface [polypeptide binding]; other site 861360007869 N-terminal domain interface [polypeptide binding]; other site 861360007870 putative substrate binding pocket (H-site) [chemical binding]; other site 861360007871 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360007872 MarR family; Region: MarR_2; pfam12802 861360007873 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360007874 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360007875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360007876 Walker A/P-loop; other site 861360007877 ATP binding site [chemical binding]; other site 861360007878 Q-loop/lid; other site 861360007879 ABC transporter signature motif; other site 861360007880 Walker B; other site 861360007881 D-loop; other site 861360007882 H-loop/switch region; other site 861360007883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360007884 MarR family; Region: MarR; pfam01047 861360007885 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 861360007886 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 861360007887 Walker A/P-loop; other site 861360007888 ATP binding site [chemical binding]; other site 861360007889 Q-loop/lid; other site 861360007890 ABC transporter signature motif; other site 861360007891 Walker B; other site 861360007892 D-loop; other site 861360007893 H-loop/switch region; other site 861360007894 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360007895 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360007896 FAD binding pocket [chemical binding]; other site 861360007897 FAD binding motif [chemical binding]; other site 861360007898 phosphate binding motif [ion binding]; other site 861360007899 NAD binding pocket [chemical binding]; other site 861360007900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 861360007901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360007902 putative PBP binding regions; other site 861360007903 ABC-ATPase subunit interface; other site 861360007904 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360007905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360007906 ABC-ATPase subunit interface; other site 861360007907 dimer interface [polypeptide binding]; other site 861360007908 putative PBP binding regions; other site 861360007909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360007910 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 861360007911 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360007912 intersubunit interface [polypeptide binding]; other site 861360007913 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360007914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 861360007915 Walker A/P-loop; other site 861360007916 ATP binding site [chemical binding]; other site 861360007917 Q-loop/lid; other site 861360007918 ABC transporter signature motif; other site 861360007919 Walker B; other site 861360007920 D-loop; other site 861360007921 H-loop/switch region; other site 861360007922 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 861360007923 Mechanosensitive ion channel; Region: MS_channel; pfam00924 861360007924 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 861360007925 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 861360007926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360007928 putative substrate translocation pore; other site 861360007929 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 861360007930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360007931 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360007932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360007933 active site 861360007934 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 861360007935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360007936 ATP binding site [chemical binding]; other site 861360007937 putative Mg++ binding site [ion binding]; other site 861360007938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360007939 nucleotide binding region [chemical binding]; other site 861360007940 ATP-binding site [chemical binding]; other site 861360007941 Helicase associated domain (HA2); Region: HA2; pfam04408 861360007942 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 861360007943 PGAP1-like protein; Region: PGAP1; pfam07819 861360007944 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 861360007945 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360007946 active site 861360007947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360007948 catalytic tetrad [active] 861360007949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360007950 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 861360007951 NAD(P) binding site [chemical binding]; other site 861360007952 catalytic residues [active] 861360007953 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 861360007954 MG2 domain; Region: A2M_N; pfam01835 861360007955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360007956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 861360007957 active site 861360007958 phosphorylation site [posttranslational modification] 861360007959 intermolecular recognition site; other site 861360007960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360007961 DNA binding residues [nucleotide binding] 861360007962 dimerization interface [polypeptide binding]; other site 861360007963 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360007964 Bacterial SH3 domain; Region: SH3_4; pfam06347 861360007965 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 861360007966 Ferritin-like domain; Region: Ferritin; pfam00210 861360007967 ferroxidase diiron center [ion binding]; other site 861360007968 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 861360007969 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 861360007970 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 861360007971 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 861360007972 RNA binding site [nucleotide binding]; other site 861360007973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 861360007974 RNA binding surface [nucleotide binding]; other site 861360007975 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 861360007976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360007977 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 861360007978 Predicted membrane protein [Function unknown]; Region: COG2860 861360007979 UPF0126 domain; Region: UPF0126; pfam03458 861360007980 UPF0126 domain; Region: UPF0126; pfam03458 861360007981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360007983 putative substrate translocation pore; other site 861360007984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360007985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360007986 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 861360007987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360007988 putative substrate translocation pore; other site 861360007989 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 861360007990 DNA-binding site [nucleotide binding]; DNA binding site 861360007991 RNA-binding motif; other site 861360007992 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 861360007993 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 861360007994 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 861360007995 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 861360007996 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360007997 AsnC family; Region: AsnC_trans_reg; pfam01037 861360007998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360007999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360008000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 861360008001 dimerization interface [polypeptide binding]; other site 861360008002 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 861360008003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360008004 substrate binding site [chemical binding]; other site 861360008005 oxyanion hole (OAH) forming residues; other site 861360008006 trimer interface [polypeptide binding]; other site 861360008007 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 861360008008 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360008009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360008010 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008011 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 861360008012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360008013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008014 Walker A/P-loop; other site 861360008015 ATP binding site [chemical binding]; other site 861360008016 Q-loop/lid; other site 861360008017 ABC transporter signature motif; other site 861360008018 Walker B; other site 861360008019 D-loop; other site 861360008020 H-loop/switch region; other site 861360008021 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 861360008022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008023 Walker A/P-loop; other site 861360008024 ATP binding site [chemical binding]; other site 861360008025 Q-loop/lid; other site 861360008026 ABC transporter signature motif; other site 861360008027 Walker B; other site 861360008028 D-loop; other site 861360008029 H-loop/switch region; other site 861360008030 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 861360008031 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 861360008032 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 861360008033 active site 861360008034 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 861360008035 active site 861360008036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360008037 Histidine kinase; Region: HisKA_3; pfam07730 861360008038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360008039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360008040 active site 861360008041 phosphorylation site [posttranslational modification] 861360008042 intermolecular recognition site; other site 861360008043 dimerization interface [polypeptide binding]; other site 861360008044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360008045 DNA binding residues [nucleotide binding] 861360008046 dimerization interface [polypeptide binding]; other site 861360008047 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 861360008048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008049 Walker A/P-loop; other site 861360008050 ATP binding site [chemical binding]; other site 861360008051 Q-loop/lid; other site 861360008052 ABC transporter signature motif; other site 861360008053 Walker B; other site 861360008054 D-loop; other site 861360008055 H-loop/switch region; other site 861360008056 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 861360008057 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 861360008058 Proline dehydrogenase; Region: Pro_dh; cl03282 861360008059 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 861360008060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360008061 NAD(P) binding site [chemical binding]; other site 861360008062 catalytic residues [active] 861360008063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360008064 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 861360008065 putative dimerization interface [polypeptide binding]; other site 861360008066 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 861360008067 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 861360008068 Na binding site [ion binding]; other site 861360008069 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 861360008070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360008071 TIGR01777 family protein; Region: yfcH 861360008072 NAD(P) binding site [chemical binding]; other site 861360008073 active site 861360008074 biotin carboxylase-like protein; Validated; Region: PRK06524 861360008075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360008076 Beta-lactamase; Region: Beta-lactamase; pfam00144 861360008077 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 861360008078 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 861360008079 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 861360008080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 861360008081 catalytic residue [active] 861360008082 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 861360008083 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360008084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360008085 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008086 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 861360008087 amidohydrolase; Region: amidohydrolases; TIGR01891 861360008088 metal binding site [ion binding]; metal-binding site 861360008089 putative dimer interface [polypeptide binding]; other site 861360008090 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 861360008091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360008092 active site 861360008093 motif I; other site 861360008094 motif II; other site 861360008095 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 861360008096 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360008097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360008098 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360008099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360008100 putative DNA binding site [nucleotide binding]; other site 861360008101 dimerization interface [polypeptide binding]; other site 861360008102 putative Zn2+ binding site [ion binding]; other site 861360008103 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360008104 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360008105 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 861360008106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 861360008107 NAD(P) binding site [chemical binding]; other site 861360008108 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 861360008109 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 861360008110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360008111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360008112 LysR substrate binding domain; Region: LysR_substrate; pfam03466 861360008113 hypothetical protein; Validated; Region: PRK06217 861360008114 AAA domain; Region: AAA_18; pfam13238 861360008115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008116 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360008117 putative substrate translocation pore; other site 861360008118 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 861360008119 CHY zinc finger; Region: zf-CHY; pfam05495 861360008120 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 861360008121 Ligand Binding Site [chemical binding]; other site 861360008122 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 861360008123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360008124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360008125 BCCT family transporter; Region: BCCT; pfam02028 861360008126 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 861360008127 active site 861360008128 catalytic triad [active] 861360008129 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 861360008130 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 861360008131 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 861360008132 putative active site [active] 861360008133 putative substrate binding site [chemical binding]; other site 861360008134 putative cosubstrate binding site; other site 861360008135 catalytic site [active] 861360008136 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 861360008137 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 861360008138 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 861360008139 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 861360008140 sarcosine oxidase, delta subunit family, heterotetrameric form; Region: soxD; TIGR01374 861360008141 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 861360008142 hydroxyglutarate oxidase; Provisional; Region: PRK11728 861360008143 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 861360008144 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 861360008145 dimer interface [polypeptide binding]; other site 861360008146 active site 861360008147 glycine-pyridoxal phosphate binding site [chemical binding]; other site 861360008148 folate binding site [chemical binding]; other site 861360008149 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360008150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360008151 DNA-binding site [nucleotide binding]; DNA binding site 861360008152 FCD domain; Region: FCD; pfam07729 861360008153 Creatinine amidohydrolase; Region: Creatininase; pfam02633 861360008154 BCCT family transporter; Region: BCCT; pfam02028 861360008155 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 861360008156 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 861360008157 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 861360008158 active site 861360008159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008160 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360008161 putative substrate translocation pore; other site 861360008162 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360008163 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360008164 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360008165 Cupin domain; Region: Cupin_2; pfam07883 861360008166 Predicted flavoprotein [General function prediction only]; Region: COG0431 861360008167 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 861360008168 Uncharacterized conserved protein [Function unknown]; Region: COG4279 861360008169 SWIM zinc finger; Region: SWIM; pfam04434 861360008170 SNF2 Helicase protein; Region: DUF3670; pfam12419 861360008171 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 861360008172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360008173 putative Mg++ binding site [ion binding]; other site 861360008174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360008175 nucleotide binding region [chemical binding]; other site 861360008176 ATP-binding site [chemical binding]; other site 861360008177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360008178 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 861360008179 dimer interface [polypeptide binding]; other site 861360008180 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 861360008181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008182 putative substrate translocation pore; other site 861360008183 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 861360008184 putative catalytic site [active] 861360008185 putative metal binding site [ion binding]; other site 861360008186 putative phosphate binding site [ion binding]; other site 861360008187 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 861360008188 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 861360008189 homodimer interface [polypeptide binding]; other site 861360008190 active site 861360008191 SAM binding site [chemical binding]; other site 861360008192 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 861360008193 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 861360008194 active site 861360008195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 861360008196 DNA binding site [nucleotide binding] 861360008197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 861360008198 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 861360008199 putative substrate binding site [chemical binding]; other site 861360008200 putative ATP binding site [chemical binding]; other site 861360008201 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360008202 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 861360008203 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360008204 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 861360008205 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 861360008206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 861360008207 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 861360008208 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 861360008209 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 861360008210 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 861360008211 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 861360008212 Helix-turn-helix domain; Region: HTH_20; pfam12840 861360008213 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 861360008214 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 861360008215 nucleotide binding site [chemical binding]; other site 861360008216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360008217 urocanate hydratase; Provisional; Region: PRK05414 861360008218 Ferritin-like domain; Region: Ferritin; pfam00210 861360008219 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 861360008220 dimerization interface [polypeptide binding]; other site 861360008221 DPS ferroxidase diiron center [ion binding]; other site 861360008222 ion pore; other site 861360008223 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 861360008224 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 861360008225 active sites [active] 861360008226 tetramer interface [polypeptide binding]; other site 861360008227 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 861360008228 tetramerization interface [polypeptide binding]; other site 861360008229 active site 861360008230 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 861360008231 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 861360008232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008233 ABC transporter signature motif; other site 861360008234 Walker B; other site 861360008235 D-loop; other site 861360008236 H-loop/switch region; other site 861360008237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008238 Walker A/P-loop; other site 861360008239 ATP binding site [chemical binding]; other site 861360008240 Q-loop/lid; other site 861360008241 ABC transporter signature motif; other site 861360008242 Walker B; other site 861360008243 D-loop; other site 861360008244 H-loop/switch region; other site 861360008245 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 861360008246 D-ribose pyranase; Provisional; Region: PRK11797 861360008247 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 861360008248 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 861360008249 substrate binding site [chemical binding]; other site 861360008250 dimer interface [polypeptide binding]; other site 861360008251 ATP binding site [chemical binding]; other site 861360008252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360008253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360008254 DNA binding site [nucleotide binding] 861360008255 domain linker motif; other site 861360008256 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 861360008257 dimerization interface [polypeptide binding]; other site 861360008258 ligand binding site [chemical binding]; other site 861360008259 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 861360008260 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 861360008261 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 861360008262 FeoA domain; Region: FeoA; pfam04023 861360008263 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 861360008264 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 861360008265 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360008266 ABC-ATPase subunit interface; other site 861360008267 dimer interface [polypeptide binding]; other site 861360008268 putative PBP binding regions; other site 861360008269 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 861360008270 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 861360008271 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 861360008272 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 861360008273 metal binding site [ion binding]; metal-binding site 861360008274 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 861360008275 putative active site [active] 861360008276 putative metal binding site [ion binding]; other site 861360008277 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 861360008278 dimer interface [polypeptide binding]; other site 861360008279 putative active site [active] 861360008280 Cupin domain; Region: Cupin_2; cl17218 861360008281 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360008282 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 861360008283 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 861360008284 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 861360008285 DNA binding residues [nucleotide binding] 861360008286 dimer interface [polypeptide binding]; other site 861360008287 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 861360008288 Helix-turn-helix domain; Region: HTH_17; pfam12728 861360008289 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360008290 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 861360008291 AsnC family; Region: AsnC_trans_reg; pfam01037 861360008292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360008293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008294 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 861360008295 Low molecular weight phosphatase family; Region: LMWPc; cl00105 861360008296 active site 861360008297 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 861360008298 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 861360008299 Ligand Binding Site [chemical binding]; other site 861360008300 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 861360008301 Ligand Binding Site [chemical binding]; other site 861360008302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 861360008303 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 861360008304 tetracycline repressor protein TetR; Provisional; Region: PRK13756 861360008305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360008306 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 861360008307 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 861360008308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360008309 putative DNA binding site [nucleotide binding]; other site 861360008310 putative Zn2+ binding site [ion binding]; other site 861360008311 AsnC family; Region: AsnC_trans_reg; pfam01037 861360008312 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 861360008313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360008315 putative substrate translocation pore; other site 861360008316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 861360008317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360008318 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 861360008319 [2Fe-2S] cluster binding site [ion binding]; other site 861360008320 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 861360008321 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 861360008322 active site 861360008323 catalytic triad [active] 861360008324 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 861360008325 L-lactate permease; Region: Lactate_perm; cl00701 861360008326 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 861360008327 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 861360008328 putative active site [active] 861360008329 metal binding site [ion binding]; metal-binding site 861360008330 Transcriptional regulators [Transcription]; Region: MarR; COG1846 861360008331 MarR family; Region: MarR_2; pfam12802 861360008332 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 861360008333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360008334 ATP binding site [chemical binding]; other site 861360008335 putative Mg++ binding site [ion binding]; other site 861360008336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360008337 nucleotide binding region [chemical binding]; other site 861360008338 ATP-binding site [chemical binding]; other site 861360008339 OsmC-like protein; Region: OsmC; pfam02566 861360008340 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 861360008341 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 861360008342 putative NAD(P) binding site [chemical binding]; other site 861360008343 catalytic Zn binding site [ion binding]; other site 861360008344 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 861360008345 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 861360008346 NADP binding site [chemical binding]; other site 861360008347 homodimer interface [polypeptide binding]; other site 861360008348 active site 861360008349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360008350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360008351 DNA-binding site [nucleotide binding]; DNA binding site 861360008352 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 861360008353 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 861360008354 L-lactate permease; Region: Lactate_perm; cl00701 861360008355 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 861360008356 Cysteine-rich domain; Region: CCG; pfam02754 861360008357 Cysteine-rich domain; Region: CCG; pfam02754 861360008358 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 861360008359 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 861360008360 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 861360008361 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 861360008362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008363 putative substrate translocation pore; other site 861360008364 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 861360008365 Uncharacterized conserved protein [Function unknown]; Region: COG2353 861360008366 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 861360008367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360008368 dimer interface [polypeptide binding]; other site 861360008369 conserved gate region; other site 861360008370 ABC-ATPase subunit interface; other site 861360008371 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 861360008372 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 861360008373 Walker A/P-loop; other site 861360008374 ATP binding site [chemical binding]; other site 861360008375 Q-loop/lid; other site 861360008376 ABC transporter signature motif; other site 861360008377 Walker B; other site 861360008378 D-loop; other site 861360008379 H-loop/switch region; other site 861360008380 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 861360008381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360008382 dimer interface [polypeptide binding]; other site 861360008383 conserved gate region; other site 861360008384 putative PBP binding loops; other site 861360008385 ABC-ATPase subunit interface; other site 861360008386 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 861360008387 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 861360008388 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 861360008389 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 861360008390 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 861360008391 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 861360008392 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 861360008393 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 861360008394 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 861360008395 Malic enzyme, N-terminal domain; Region: malic; pfam00390 861360008396 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 861360008397 putative NAD(P) binding site [chemical binding]; other site 861360008398 Helix-turn-helix domain; Region: HTH_17; pfam12728 861360008399 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 861360008400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360008401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360008402 homodimer interface [polypeptide binding]; other site 861360008403 catalytic residue [active] 861360008404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360008405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360008406 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 861360008407 putative dimerization interface [polypeptide binding]; other site 861360008408 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 861360008409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360008410 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 861360008411 NAD(P) binding site [chemical binding]; other site 861360008412 active site 861360008413 NUDIX domain; Region: NUDIX; pfam00293 861360008414 nudix motif; other site 861360008415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 861360008416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360008417 active site 861360008418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 861360008419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360008420 Coenzyme A binding pocket [chemical binding]; other site 861360008421 Predicted transcriptional regulators [Transcription]; Region: COG1733 861360008422 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 861360008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360008424 NADH(P)-binding; Region: NAD_binding_10; pfam13460 861360008425 NAD(P) binding site [chemical binding]; other site 861360008426 active site 861360008427 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 861360008428 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 861360008429 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360008430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360008431 dimer interface [polypeptide binding]; other site 861360008432 conserved gate region; other site 861360008433 putative PBP binding loops; other site 861360008434 ABC-ATPase subunit interface; other site 861360008435 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 861360008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360008437 dimer interface [polypeptide binding]; other site 861360008438 conserved gate region; other site 861360008439 putative PBP binding loops; other site 861360008440 ABC-ATPase subunit interface; other site 861360008441 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360008442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360008443 Walker A/P-loop; other site 861360008444 ATP binding site [chemical binding]; other site 861360008445 Q-loop/lid; other site 861360008446 ABC transporter signature motif; other site 861360008447 Walker B; other site 861360008448 D-loop; other site 861360008449 H-loop/switch region; other site 861360008450 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 861360008451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360008452 Walker A/P-loop; other site 861360008453 ATP binding site [chemical binding]; other site 861360008454 Q-loop/lid; other site 861360008455 ABC transporter signature motif; other site 861360008456 Walker B; other site 861360008457 D-loop; other site 861360008458 H-loop/switch region; other site 861360008459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 861360008460 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 861360008461 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 861360008462 Walker A/P-loop; other site 861360008463 ATP binding site [chemical binding]; other site 861360008464 Q-loop/lid; other site 861360008465 ABC transporter signature motif; other site 861360008466 Walker B; other site 861360008467 D-loop; other site 861360008468 H-loop/switch region; other site 861360008469 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 861360008470 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 861360008471 acyl-activating enzyme (AAE) consensus motif; other site 861360008472 putative AMP binding site [chemical binding]; other site 861360008473 putative active site [active] 861360008474 putative CoA binding site [chemical binding]; other site 861360008475 Nuclease-related domain; Region: NERD; pfam08378 861360008476 Family description; Region: UvrD_C_2; pfam13538 861360008477 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 861360008478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 861360008479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 861360008480 catalytic residue [active] 861360008481 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360008482 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360008483 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360008484 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 861360008485 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 861360008486 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 861360008487 putative acyltransferase; Provisional; Region: PRK05790 861360008488 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 861360008489 dimer interface [polypeptide binding]; other site 861360008490 active site 861360008491 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 861360008492 catalytic core [active] 861360008493 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360008494 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 861360008495 active site 861360008496 metal binding site [ion binding]; metal-binding site 861360008497 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 861360008498 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 861360008499 dimer interface [polypeptide binding]; other site 861360008500 active site 861360008501 CoA binding pocket [chemical binding]; other site 861360008502 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 861360008503 putative hydrophobic ligand binding site [chemical binding]; other site 861360008504 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360008505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360008506 DNA-binding site [nucleotide binding]; DNA binding site 861360008507 FCD domain; Region: FCD; pfam07729 861360008508 L-asparaginase II; Region: Asparaginase_II; pfam06089 861360008509 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 861360008510 Aspartase; Region: Aspartase; cd01357 861360008511 active sites [active] 861360008512 tetramer interface [polypeptide binding]; other site 861360008513 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 861360008514 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360008515 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 861360008516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360008517 DNA binding residues [nucleotide binding] 861360008518 Uncharacterized conserved protein [Function unknown]; Region: COG2128 861360008519 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 861360008520 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 861360008521 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 861360008522 E3 interaction surface; other site 861360008523 lipoyl attachment site [posttranslational modification]; other site 861360008524 e3 binding domain; Region: E3_binding; pfam02817 861360008525 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 861360008526 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 861360008527 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 861360008528 alpha subunit interface [polypeptide binding]; other site 861360008529 TPP binding site [chemical binding]; other site 861360008530 heterodimer interface [polypeptide binding]; other site 861360008531 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360008532 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 861360008533 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 861360008534 TPP-binding site [chemical binding]; other site 861360008535 heterodimer interface [polypeptide binding]; other site 861360008536 tetramer interface [polypeptide binding]; other site 861360008537 phosphorylation loop region [posttranslational modification] 861360008538 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 861360008539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360008540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360008541 homodimer interface [polypeptide binding]; other site 861360008542 catalytic residue [active] 861360008543 Membrane protein of unknown function; Region: DUF360; pfam04020 861360008544 adenylosuccinate lyase; Provisional; Region: PRK09285 861360008545 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 861360008546 tetramer interface [polypeptide binding]; other site 861360008547 active site 861360008548 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 861360008549 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 861360008550 XdhC Rossmann domain; Region: XdhC_C; pfam13478 861360008551 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 861360008552 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 861360008553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 861360008554 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 861360008555 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 861360008556 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 861360008557 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 861360008558 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 861360008559 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 861360008560 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 861360008561 [4Fe-4S] binding site [ion binding]; other site 861360008562 molybdopterin cofactor binding site; other site 861360008563 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 861360008564 molybdopterin cofactor binding site; other site 861360008565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 861360008566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360008567 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 861360008568 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 861360008569 nitrite reductase subunit NirD; Provisional; Region: PRK14989 861360008570 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 861360008571 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 861360008572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 861360008573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360008574 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360008575 active site 861360008576 catalytic tetrad [active] 861360008577 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 861360008578 SPFH domain / Band 7 family; Region: Band_7; pfam01145 861360008579 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 861360008580 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 861360008581 putative molybdopterin cofactor binding site [chemical binding]; other site 861360008582 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 861360008583 putative molybdopterin cofactor binding site; other site 861360008584 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 861360008585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 861360008586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360008587 Coenzyme A binding pocket [chemical binding]; other site 861360008588 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 861360008589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360008590 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 861360008591 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 861360008592 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 861360008593 acyl-activating enzyme (AAE) consensus motif; other site 861360008594 putative AMP binding site [chemical binding]; other site 861360008595 putative active site [active] 861360008596 putative CoA binding site [chemical binding]; other site 861360008597 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 861360008598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 861360008599 substrate binding site [chemical binding]; other site 861360008600 oxyanion hole (OAH) forming residues; other site 861360008601 trimer interface [polypeptide binding]; other site 861360008602 Protein of unknown function (DUF456); Region: DUF456; pfam04306 861360008603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360008605 active site 861360008606 phosphorylation site [posttranslational modification] 861360008607 intermolecular recognition site; other site 861360008608 dimerization interface [polypeptide binding]; other site 861360008609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360008610 DNA binding residues [nucleotide binding] 861360008611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360008612 Histidine kinase; Region: HisKA_3; pfam07730 861360008613 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 861360008614 ABC-2 type transporter; Region: ABC2_membrane; cl17235 861360008615 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 861360008616 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 861360008617 Walker A/P-loop; other site 861360008618 ATP binding site [chemical binding]; other site 861360008619 Q-loop/lid; other site 861360008620 ABC transporter signature motif; other site 861360008621 Walker B; other site 861360008622 D-loop; other site 861360008623 H-loop/switch region; other site 861360008624 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 861360008625 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 861360008626 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 861360008627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360008628 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360008629 DNA binding residues [nucleotide binding] 861360008630 dimerization interface [polypeptide binding]; other site 861360008631 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360008632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 861360008633 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360008634 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 861360008635 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 861360008636 Catalytic site [active] 861360008637 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 861360008638 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 861360008639 Catalytic site [active] 861360008640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360008641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008642 aspartate aminotransferase; Provisional; Region: PRK05764 861360008643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 861360008644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 861360008645 homodimer interface [polypeptide binding]; other site 861360008646 catalytic residue [active] 861360008647 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 861360008648 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360008649 Uncharacterized membrane protein [Function unknown]; Region: COG3949 861360008650 Helix-turn-helix domain; Region: HTH_28; pfam13518 861360008651 Winged helix-turn helix; Region: HTH_29; pfam13551 861360008652 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 861360008653 Integrase core domain; Region: rve; pfam00665 861360008654 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 861360008655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 861360008656 motif II; other site 861360008657 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 861360008658 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 861360008659 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 861360008660 Uncharacterized conserved protein [Function unknown]; Region: COG1262 861360008661 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 861360008662 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 861360008663 Transposase; Region: HTH_Tnp_1; pfam01527 861360008664 putative transposase OrfB; Reviewed; Region: PHA02517 861360008665 HTH-like domain; Region: HTH_21; pfam13276 861360008666 Integrase core domain; Region: rve; pfam00665 861360008667 Integrase core domain; Region: rve_3; pfam13683 861360008668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 861360008669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 861360008670 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 861360008671 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 861360008672 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 861360008673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360008674 S-adenosylmethionine binding site [chemical binding]; other site 861360008675 binding surface 861360008676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 861360008677 TPR motif; other site 861360008678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 861360008679 binding surface 861360008680 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360008681 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008682 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 861360008683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360008684 Soluble P-type ATPase [General function prediction only]; Region: COG4087 861360008685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360008686 dimerization interface [polypeptide binding]; other site 861360008687 putative DNA binding site [nucleotide binding]; other site 861360008688 putative Zn2+ binding site [ion binding]; other site 861360008689 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360008690 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008691 Predicted membrane protein [Function unknown]; Region: COG4709 861360008692 Predicted transcriptional regulators [Transcription]; Region: COG1695 861360008693 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 861360008694 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 861360008695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 861360008696 Integrase core domain; Region: rve; pfam00665 861360008697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360008698 Walker A motif; other site 861360008699 ATP binding site [chemical binding]; other site 861360008700 Walker B motif; other site 861360008701 Transposase, Mutator family; Region: Transposase_mut; pfam00872 861360008702 MULE transposase domain; Region: MULE; pfam10551 861360008703 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 861360008704 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 861360008705 MULE transposase domain; Region: MULE; pfam10551 861360008706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360008707 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 861360008708 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008709 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 861360008710 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 861360008711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360008712 non-specific DNA binding site [nucleotide binding]; other site 861360008713 salt bridge; other site 861360008714 sequence-specific DNA binding site [nucleotide binding]; other site 861360008715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360008716 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008717 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360008718 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 861360008719 catalytic residues [active] 861360008720 catalytic nucleophile [active] 861360008721 Recombinase; Region: Recombinase; pfam07508 861360008722 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 861360008723 putative transposase OrfB; Reviewed; Region: PHA02517 861360008724 HTH-like domain; Region: HTH_21; pfam13276 861360008725 Integrase core domain; Region: rve; pfam00665 861360008726 Integrase core domain; Region: rve_3; pfam13683 861360008727 Transposase; Region: HTH_Tnp_1; pfam01527 861360008728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360008729 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 861360008730 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 861360008731 Putative amidase domain; Region: Amidase_6; pfam12671 861360008732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360008733 Walker A motif; other site 861360008734 ATP binding site [chemical binding]; other site 861360008735 Walker B motif; other site 861360008736 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360008737 multiple promoter invertase; Provisional; Region: mpi; PRK13413 861360008738 catalytic residues [active] 861360008739 catalytic nucleophile [active] 861360008740 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360008741 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360008742 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360008743 Synaptic Site I dimer interface [polypeptide binding]; other site 861360008744 DNA binding site [nucleotide binding] 861360008745 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360008746 DNA-binding interface [nucleotide binding]; DNA binding site 861360008747 Protein of unknown function (DUF805); Region: DUF805; pfam05656 861360008748 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 861360008749 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 861360008750 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 861360008751 Transposase; Region: HTH_Tnp_1; pfam01527 861360008752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360008753 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 861360008754 HTH-like domain; Region: HTH_21; pfam13276 861360008755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360008756 Integrase core domain; Region: rve; pfam00665 861360008757 Integrase core domain; Region: rve_3; pfam13683 861360008758 Transposase; Region: HTH_Tnp_1; cl17663 861360008759 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 861360008760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360008761 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 861360008762 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 861360008763 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360008764 catalytic residues [active] 861360008765 catalytic nucleophile [active] 861360008766 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360008767 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360008768 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360008769 Synaptic Site I dimer interface [polypeptide binding]; other site 861360008770 DNA binding site [nucleotide binding] 861360008771 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 861360008772 DNA-binding interface [nucleotide binding]; DNA binding site 861360008773 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360008774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360008775 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008776 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 861360008777 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 861360008778 metal binding site [ion binding]; metal-binding site 861360008779 Abi-like protein; Region: Abi_2; pfam07751 861360008780 Predicted flavoprotein [General function prediction only]; Region: COG0431 861360008781 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 861360008782 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 861360008783 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 861360008784 dimer interface [polypeptide binding]; other site 861360008785 putative radical transfer pathway; other site 861360008786 diiron center [ion binding]; other site 861360008787 tyrosyl radical; other site 861360008788 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 861360008789 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 861360008790 Class I ribonucleotide reductase; Region: RNR_I; cd01679 861360008791 active site 861360008792 dimer interface [polypeptide binding]; other site 861360008793 catalytic residues [active] 861360008794 effector binding site; other site 861360008795 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 861360008796 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 861360008797 Zeta toxin; Region: Zeta_toxin; pfam06414 861360008798 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 861360008799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 861360008800 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 861360008801 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 861360008802 AAA-like domain; Region: AAA_10; pfam12846 861360008803 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 861360008804 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 861360008805 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 861360008806 N-acetyl-D-glucosamine binding site [chemical binding]; other site 861360008807 catalytic residue [active] 861360008808 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 861360008809 Peptidase family M23; Region: Peptidase_M23; pfam01551 861360008810 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 861360008811 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360008812 P-loop; other site 861360008813 Magnesium ion binding site [ion binding]; other site 861360008814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360008815 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008816 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 861360008817 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 861360008818 Walker A/P-loop; other site 861360008819 ATP binding site [chemical binding]; other site 861360008820 Q-loop/lid; other site 861360008821 ABC transporter signature motif; other site 861360008822 Walker B; other site 861360008823 D-loop; other site 861360008824 H-loop/switch region; other site 861360008825 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360008826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360008827 ABC-ATPase subunit interface; other site 861360008828 dimer interface [polypeptide binding]; other site 861360008829 putative PBP binding regions; other site 861360008830 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 861360008831 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360008832 intersubunit interface [polypeptide binding]; other site 861360008833 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 861360008834 metal-binding site [ion binding] 861360008835 DJ-1 family protein; Region: not_thiJ; TIGR01383 861360008836 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 861360008837 conserved cys residue [active] 861360008838 Transposase; Region: HTH_Tnp_1; pfam01527 861360008839 putative transposase OrfB; Reviewed; Region: PHA02517 861360008840 HTH-like domain; Region: HTH_21; pfam13276 861360008841 Integrase core domain; Region: rve; pfam00665 861360008842 Integrase core domain; Region: rve_3; pfam13683 861360008843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360008844 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360008845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 861360008846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360008847 P-loop; other site 861360008848 Magnesium ion binding site [ion binding]; other site 861360008849 HicB family; Region: HicB; pfam05534 861360008850 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 861360008851 catalytic residues [active] 861360008852 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 861360008853 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 861360008854 Predicted helicase [General function prediction only]; Region: COG4889 861360008855 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 861360008856 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 861360008857 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 861360008858 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 861360008859 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 861360008860 Protein of unknown function (DUF461); Region: DUF461; pfam04314 861360008861 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 861360008862 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 861360008863 metal binding site [ion binding]; metal-binding site 861360008864 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 861360008865 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 861360008866 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 861360008867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360008868 ABC-ATPase subunit interface; other site 861360008869 dimer interface [polypeptide binding]; other site 861360008870 putative PBP binding regions; other site 861360008871 multiple promoter invertase; Provisional; Region: mpi; PRK13413 861360008872 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 861360008873 catalytic residues [active] 861360008874 catalytic nucleophile [active] 861360008875 Presynaptic Site I dimer interface [polypeptide binding]; other site 861360008876 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 861360008877 Synaptic Flat tetramer interface [polypeptide binding]; other site 861360008878 Synaptic Site I dimer interface [polypeptide binding]; other site 861360008879 DNA binding site [nucleotide binding] 861360008880 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 861360008881 DNA-binding interface [nucleotide binding]; DNA binding site 861360008882 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 861360008883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360008884 Transposase; Region: HTH_Tnp_1; pfam01527 861360008885 putative transposase OrfB; Reviewed; Region: PHA02517 861360008886 HTH-like domain; Region: HTH_21; pfam13276 861360008887 Integrase core domain; Region: rve; pfam00665 861360008888 Integrase core domain; Region: rve_3; pfam13683 861360008889 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 861360008890 Restriction endonuclease; Region: Mrr_cat; pfam04471 861360008891 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360008892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 861360008893 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360008894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 861360008895 Transposase; Region: HTH_Tnp_1; cl17663 861360008896 putative transposase OrfB; Reviewed; Region: PHA02517 861360008897 HTH-like domain; Region: HTH_21; pfam13276 861360008898 Integrase core domain; Region: rve; pfam00665 861360008899 Integrase core domain; Region: rve_3; pfam13683 861360008900 HTH-like domain; Region: HTH_21; pfam13276 861360008901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 861360008902 Integrase core domain; Region: rve; pfam00665 861360008903 Integrase core domain; Region: rve_3; pfam13683 861360008904 Transposase; Region: HTH_Tnp_1; pfam01527 861360008905 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 861360008906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 861360008907 FeS/SAM binding site; other site 861360008908 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 861360008909 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 861360008910 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 861360008911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360008912 S-adenosylmethionine binding site [chemical binding]; other site 861360008913 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 861360008914 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 861360008915 malonyl-CoA binding site [chemical binding]; other site 861360008916 dimer interface [polypeptide binding]; other site 861360008917 active site 861360008918 product binding site; other site 861360008919 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 861360008920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360008921 DNA-binding site [nucleotide binding]; DNA binding site 861360008922 FCD domain; Region: FCD; pfam07729 861360008923 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 861360008924 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 861360008925 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 861360008926 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 861360008927 Catalytic site [active] 861360008928 glutaminase; Reviewed; Region: PRK12356 861360008929 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 861360008930 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 861360008931 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 861360008932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 861360008933 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 861360008934 active site 861360008935 catalytic triad [active] 861360008936 oxyanion hole [active] 861360008937 Histidine kinase; Region: HisKA_3; pfam07730 861360008938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 861360008939 ATP binding site [chemical binding]; other site 861360008940 Mg2+ binding site [ion binding]; other site 861360008941 G-X-G motif; other site 861360008942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360008943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360008944 active site 861360008945 phosphorylation site [posttranslational modification] 861360008946 intermolecular recognition site; other site 861360008947 dimerization interface [polypeptide binding]; other site 861360008948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360008949 DNA binding residues [nucleotide binding] 861360008950 dimerization interface [polypeptide binding]; other site 861360008951 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 861360008952 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 861360008953 Predicted ATPase [General function prediction only]; Region: COG3910 861360008954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360008955 Walker A/P-loop; other site 861360008956 ATP binding site [chemical binding]; other site 861360008957 Q-loop/lid; other site 861360008958 ABC transporter signature motif; other site 861360008959 Walker B; other site 861360008960 D-loop; other site 861360008961 H-loop/switch region; other site 861360008962 phenol 2-monooxygenase; Provisional; Region: PRK08294 861360008963 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 861360008964 dimer interface [polypeptide binding]; other site 861360008965 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360008966 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 861360008967 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 861360008968 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 861360008969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360008970 Yqey-like protein; Region: YqeY; cl17540 861360008971 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 861360008972 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 861360008973 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 861360008974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 861360008975 FemAB family; Region: FemAB; pfam02388 861360008976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 861360008977 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 861360008978 putative homodimer interface [polypeptide binding]; other site 861360008979 putative homotetramer interface [polypeptide binding]; other site 861360008980 putative allosteric switch controlling residues; other site 861360008981 putative metal binding site [ion binding]; other site 861360008982 putative homodimer-homodimer interface [polypeptide binding]; other site 861360008983 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 861360008984 metal-binding site [ion binding] 861360008985 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 861360008986 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 861360008987 metal-binding site [ion binding] 861360008988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 861360008989 Soluble P-type ATPase [General function prediction only]; Region: COG4087 861360008990 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 861360008991 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 861360008992 DCoH dimer interaction site [polypeptide binding]; other site 861360008993 aromatic arch; other site 861360008994 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 861360008995 DCoH tetramer interaction site [polypeptide binding]; other site 861360008996 substrate binding site [chemical binding]; other site 861360008997 EamA-like transporter family; Region: EamA; pfam00892 861360008998 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 861360008999 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 861360009000 CGNR zinc finger; Region: zf-CGNR; pfam11706 861360009001 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 861360009002 amino acid transporter; Region: 2A0306; TIGR00909 861360009003 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 861360009004 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 861360009005 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 861360009006 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 861360009007 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 861360009008 phosphate binding site [ion binding]; other site 861360009009 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360009010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009011 Transcriptional regulators [Transcription]; Region: FadR; COG2186 861360009012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360009013 DNA-binding site [nucleotide binding]; DNA binding site 861360009014 FCD domain; Region: FCD; pfam07729 861360009015 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 861360009016 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 861360009017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 861360009018 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 861360009019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009020 putative substrate translocation pore; other site 861360009021 CAAX protease self-immunity; Region: Abi; pfam02517 861360009022 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360009023 Bacterial SH3 domain; Region: SH3_3; pfam08239 861360009024 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 861360009025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360009026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360009027 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 861360009028 Walker A/P-loop; other site 861360009029 ATP binding site [chemical binding]; other site 861360009030 Q-loop/lid; other site 861360009031 ABC transporter signature motif; other site 861360009032 Walker B; other site 861360009033 D-loop; other site 861360009034 H-loop/switch region; other site 861360009035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360009036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360009037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360009038 Walker A/P-loop; other site 861360009039 ATP binding site [chemical binding]; other site 861360009040 Q-loop/lid; other site 861360009041 ABC transporter signature motif; other site 861360009042 Walker B; other site 861360009043 D-loop; other site 861360009044 H-loop/switch region; other site 861360009045 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 861360009046 aromatic arch; other site 861360009047 DCoH dimer interaction site [polypeptide binding]; other site 861360009048 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 861360009049 DCoH tetramer interaction site [polypeptide binding]; other site 861360009050 substrate binding site [chemical binding]; other site 861360009051 Predicted membrane protein [Function unknown]; Region: COG2323 861360009052 Isochorismatase family; Region: Isochorismatase; pfam00857 861360009053 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 861360009054 catalytic triad [active] 861360009055 conserved cis-peptide bond; other site 861360009056 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 861360009057 oxidoreductase; Provisional; Region: PRK06128 861360009058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009059 NAD(P) binding site [chemical binding]; other site 861360009060 active site 861360009061 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 861360009062 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 861360009063 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 861360009064 NAD binding site [chemical binding]; other site 861360009065 catalytic Zn binding site [ion binding]; other site 861360009066 structural Zn binding site [ion binding]; other site 861360009067 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 861360009068 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 861360009069 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 861360009070 catalytic triad [active] 861360009071 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 861360009072 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 861360009073 NAD(P) binding site [chemical binding]; other site 861360009074 catalytic residues [active] 861360009075 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 861360009076 DNA photolyase; Region: DNA_photolyase; pfam00875 861360009077 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 861360009078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 861360009079 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 861360009080 putative NAD(P) binding site [chemical binding]; other site 861360009081 catalytic Zn binding site [ion binding]; other site 861360009082 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 861360009083 additional DNA contacts [nucleotide binding]; other site 861360009084 mismatch recognition site; other site 861360009085 active site 861360009086 zinc binding site [ion binding]; other site 861360009087 DNA intercalation site [nucleotide binding]; other site 861360009088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360009089 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 861360009090 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 861360009091 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360009092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360009093 dimer interface [polypeptide binding]; other site 861360009094 conserved gate region; other site 861360009095 putative PBP binding loops; other site 861360009096 ABC-ATPase subunit interface; other site 861360009097 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 861360009098 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 861360009099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360009100 dimer interface [polypeptide binding]; other site 861360009101 conserved gate region; other site 861360009102 ABC-ATPase subunit interface; other site 861360009103 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360009104 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360009105 Walker A/P-loop; other site 861360009106 ATP binding site [chemical binding]; other site 861360009107 Q-loop/lid; other site 861360009108 ABC transporter signature motif; other site 861360009109 Walker B; other site 861360009110 D-loop; other site 861360009111 H-loop/switch region; other site 861360009112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360009113 Walker A/P-loop; other site 861360009114 ATP binding site [chemical binding]; other site 861360009115 Q-loop/lid; other site 861360009116 ABC transporter signature motif; other site 861360009117 Walker B; other site 861360009118 D-loop; other site 861360009119 H-loop/switch region; other site 861360009120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360009121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360009122 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360009123 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 861360009124 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 861360009125 heterodimer interface [polypeptide binding]; other site 861360009126 active site 861360009127 FMN binding site [chemical binding]; other site 861360009128 homodimer interface [polypeptide binding]; other site 861360009129 substrate binding site [chemical binding]; other site 861360009130 benzoate transport; Region: 2A0115; TIGR00895 861360009131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009132 putative substrate translocation pore; other site 861360009133 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 861360009134 allantoate amidohydrolase; Reviewed; Region: PRK09290 861360009135 active site 861360009136 metal binding site [ion binding]; metal-binding site 861360009137 dimer interface [polypeptide binding]; other site 861360009138 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 861360009139 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 861360009140 FAD binding pocket [chemical binding]; other site 861360009141 FAD binding motif [chemical binding]; other site 861360009142 phosphate binding motif [ion binding]; other site 861360009143 beta-alpha-beta structure motif; other site 861360009144 NAD binding pocket [chemical binding]; other site 861360009145 Iron coordination center [ion binding]; other site 861360009146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 861360009147 dihydroorotase; Validated; Region: pyrC; PRK09357 861360009148 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 861360009149 active site 861360009150 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 861360009151 Aspartase; Region: Aspartase; cd01357 861360009152 active sites [active] 861360009153 tetramer interface [polypeptide binding]; other site 861360009154 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 861360009155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360009156 substrate binding pocket [chemical binding]; other site 861360009157 membrane-bound complex binding site; other site 861360009158 hinge residues; other site 861360009159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 861360009160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009161 NAD(P) binding site [chemical binding]; other site 861360009162 active site 861360009163 metabolite-proton symporter; Region: 2A0106; TIGR00883 861360009164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009165 putative substrate translocation pore; other site 861360009166 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 861360009167 TPP-binding site [chemical binding]; other site 861360009168 dimer interface [polypeptide binding]; other site 861360009169 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 861360009170 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 861360009171 PYR/PP interface [polypeptide binding]; other site 861360009172 dimer interface [polypeptide binding]; other site 861360009173 TPP binding site [chemical binding]; other site 861360009174 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 861360009175 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360009176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360009177 DNA-binding site [nucleotide binding]; DNA binding site 861360009178 FCD domain; Region: FCD; pfam07729 861360009179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360009180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360009181 non-specific DNA binding site [nucleotide binding]; other site 861360009182 salt bridge; other site 861360009183 sequence-specific DNA binding site [nucleotide binding]; other site 861360009184 HipA N-terminal domain; Region: Couple_hipA; cl11853 861360009185 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 861360009186 HipA-like N-terminal domain; Region: HipA_N; pfam07805 861360009187 HipA-like C-terminal domain; Region: HipA_C; pfam07804 861360009188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 861360009189 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 861360009190 FMN binding site [chemical binding]; other site 861360009191 active site 861360009192 substrate binding site [chemical binding]; other site 861360009193 catalytic residue [active] 861360009194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 861360009196 NAD(P) binding site [chemical binding]; other site 861360009197 active site 861360009198 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 861360009199 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 861360009200 Walker A/P-loop; other site 861360009201 ATP binding site [chemical binding]; other site 861360009202 Q-loop/lid; other site 861360009203 ABC transporter signature motif; other site 861360009204 Walker B; other site 861360009205 D-loop; other site 861360009206 H-loop/switch region; other site 861360009207 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 861360009208 Walker A/P-loop; other site 861360009209 ATP binding site [chemical binding]; other site 861360009210 Q-loop/lid; other site 861360009211 ABC transporter signature motif; other site 861360009212 Walker B; other site 861360009213 D-loop; other site 861360009214 H-loop/switch region; other site 861360009215 Cobalt transport protein; Region: CbiQ; cl00463 861360009216 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 861360009217 active site 861360009218 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 861360009219 PLD-like domain; Region: PLDc_2; pfam13091 861360009220 putative homodimer interface [polypeptide binding]; other site 861360009221 putative active site [active] 861360009222 catalytic site [active] 861360009223 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 861360009224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360009225 ATP binding site [chemical binding]; other site 861360009226 putative Mg++ binding site [ion binding]; other site 861360009227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 861360009228 nucleotide binding region [chemical binding]; other site 861360009229 ATP-binding site [chemical binding]; other site 861360009230 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 861360009231 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 861360009232 active site 861360009233 8-oxo-dGMP binding site [chemical binding]; other site 861360009234 nudix motif; other site 861360009235 metal binding site [ion binding]; metal-binding site 861360009236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009237 D-galactonate transporter; Region: 2A0114; TIGR00893 861360009238 putative substrate translocation pore; other site 861360009239 galactonate dehydratase; Provisional; Region: PRK14017 861360009240 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 861360009241 putative active site pocket [active] 861360009242 putative metal binding site [ion binding]; other site 861360009243 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 861360009244 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 861360009245 active site 861360009246 intersubunit interface [polypeptide binding]; other site 861360009247 catalytic residue [active] 861360009248 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 861360009249 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 861360009250 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360009251 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 861360009252 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360009253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360009254 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 861360009255 Walker A/P-loop; other site 861360009256 ATP binding site [chemical binding]; other site 861360009257 Q-loop/lid; other site 861360009258 ABC transporter signature motif; other site 861360009259 Walker B; other site 861360009260 D-loop; other site 861360009261 H-loop/switch region; other site 861360009262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 861360009263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 861360009264 Walker A/P-loop; other site 861360009265 ATP binding site [chemical binding]; other site 861360009266 Q-loop/lid; other site 861360009267 ABC transporter signature motif; other site 861360009268 Walker B; other site 861360009269 D-loop; other site 861360009270 H-loop/switch region; other site 861360009271 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 861360009272 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 861360009273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 861360009274 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 861360009275 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 861360009276 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 861360009277 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 861360009278 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 861360009279 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 861360009280 intracellular protease, PfpI family; Region: PfpI; TIGR01382 861360009281 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 861360009282 proposed catalytic triad [active] 861360009283 conserved cys residue [active] 861360009284 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 861360009285 PBP superfamily domain; Region: PBP_like_2; cl17296 861360009286 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 861360009287 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 861360009288 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 861360009289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 861360009290 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 861360009291 Low molecular weight phosphatase family; Region: LMWPc; cd00115 861360009292 active site 861360009293 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 861360009294 arsenical-resistance protein; Region: acr3; TIGR00832 861360009295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 861360009296 dimerization interface [polypeptide binding]; other site 861360009297 putative DNA binding site [nucleotide binding]; other site 861360009298 putative Zn2+ binding site [ion binding]; other site 861360009299 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 861360009300 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 861360009301 Cation efflux family; Region: Cation_efflux; pfam01545 861360009302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 861360009303 substrate binding pocket [chemical binding]; other site 861360009304 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360009305 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360009306 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360009307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 861360009308 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360009309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009310 putative substrate translocation pore; other site 861360009311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360009312 Domain of unknown function DUF21; Region: DUF21; pfam01595 861360009313 FOG: CBS domain [General function prediction only]; Region: COG0517 861360009314 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 861360009315 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 861360009316 Domain of unknown function DUF21; Region: DUF21; pfam01595 861360009317 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 861360009318 Transporter associated domain; Region: CorC_HlyC; pfam03471 861360009319 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 861360009320 glutaminase; Provisional; Region: PRK00971 861360009321 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 861360009322 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 861360009323 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 861360009324 active site 861360009325 catalytic site [active] 861360009326 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 861360009327 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 861360009328 Abi-like protein; Region: Abi_2; pfam07751 861360009329 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 861360009330 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 861360009331 putative active site [active] 861360009332 Zn binding site [ion binding]; other site 861360009333 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 861360009334 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 861360009335 Na binding site [ion binding]; other site 861360009336 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 861360009337 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 861360009338 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 861360009339 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 861360009340 putative active site [active] 861360009341 putative substrate binding site [chemical binding]; other site 861360009342 putative cosubstrate binding site; other site 861360009343 catalytic site [active] 861360009344 Transcriptional regulators [Transcription]; Region: GntR; COG1802 861360009345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 861360009346 DNA-binding site [nucleotide binding]; DNA binding site 861360009347 FCD domain; Region: FCD; pfam07729 861360009348 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 861360009349 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 861360009350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 861360009351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 861360009352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 861360009353 DNA binding residues [nucleotide binding] 861360009354 Putative zinc-finger; Region: zf-HC2; pfam13490 861360009355 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 861360009356 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 861360009357 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 861360009358 DXD motif; other site 861360009359 Cellulose synthase-like protein; Region: PLN02893 861360009360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009361 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360009362 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 861360009363 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 861360009364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 861360009365 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360009366 Cna protein B-type domain; Region: Cna_B; pfam05738 861360009367 Cna protein B-type domain; Region: Cna_B; pfam05738 861360009368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360009369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360009370 DNA binding residues [nucleotide binding] 861360009371 dimerization interface [polypeptide binding]; other site 861360009372 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 861360009373 allantoinase; Region: allantoinase; TIGR03178 861360009374 active site 861360009375 glyoxylate carboligase; Provisional; Region: PRK11269 861360009376 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 861360009377 PYR/PP interface [polypeptide binding]; other site 861360009378 dimer interface [polypeptide binding]; other site 861360009379 TPP binding site [chemical binding]; other site 861360009380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 861360009381 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 861360009382 TPP-binding site [chemical binding]; other site 861360009383 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 861360009384 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 861360009385 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 861360009386 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 861360009387 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 861360009388 Na binding site [ion binding]; other site 861360009389 putative substrate binding site [chemical binding]; other site 861360009390 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 861360009391 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 861360009392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009393 NADH(P)-binding; Region: NAD_binding_10; pfam13460 861360009394 NAD(P) binding site [chemical binding]; other site 861360009395 active site 861360009396 Protein of unknown function, DUF488; Region: DUF488; pfam04343 861360009397 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 861360009398 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360009399 intersubunit interface [polypeptide binding]; other site 861360009400 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360009401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360009402 ABC-ATPase subunit interface; other site 861360009403 dimer interface [polypeptide binding]; other site 861360009404 putative PBP binding regions; other site 861360009405 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360009406 ABC-ATPase subunit interface; other site 861360009407 dimer interface [polypeptide binding]; other site 861360009408 putative PBP binding regions; other site 861360009409 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 861360009410 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 861360009411 Walker A/P-loop; other site 861360009412 ATP binding site [chemical binding]; other site 861360009413 Q-loop/lid; other site 861360009414 ABC transporter signature motif; other site 861360009415 Walker B; other site 861360009416 D-loop; other site 861360009417 H-loop/switch region; other site 861360009418 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 861360009419 active site clefts [active] 861360009420 zinc binding site [ion binding]; other site 861360009421 dimer interface [polypeptide binding]; other site 861360009422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360009423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360009424 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 861360009425 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 861360009426 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 861360009427 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 861360009428 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 861360009429 ATP-grasp domain; Region: ATP-grasp_4; cl17255 861360009430 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 861360009431 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 861360009432 carboxyltransferase (CT) interaction site; other site 861360009433 biotinylation site [posttranslational modification]; other site 861360009434 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 861360009435 putative active site [active] 861360009436 putative catalytic site [active] 861360009437 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 861360009438 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 861360009439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009440 putative substrate translocation pore; other site 861360009441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360009442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360009443 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360009444 Helix-turn-helix domain; Region: HTH_28; pfam13518 861360009445 Winged helix-turn helix; Region: HTH_29; pfam13551 861360009446 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 861360009447 Integrase core domain; Region: rve; pfam00665 861360009448 Domain of unknown function (DUF202); Region: DUF202; pfam02656 861360009449 Domain of unknown function (DUF202); Region: DUF202; cl09954 861360009450 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 861360009451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 861360009452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360009453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 861360009454 dimerization interface [polypeptide binding]; other site 861360009455 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 861360009456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360009457 active site 861360009458 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 861360009459 active site 861360009460 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360009461 ABC-ATPase subunit interface; other site 861360009462 dimer interface [polypeptide binding]; other site 861360009463 putative PBP binding regions; other site 861360009464 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 861360009465 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 861360009466 ABC-ATPase subunit interface; other site 861360009467 dimer interface [polypeptide binding]; other site 861360009468 putative PBP binding regions; other site 861360009469 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 861360009470 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 861360009471 FAD binding pocket [chemical binding]; other site 861360009472 FAD binding motif [chemical binding]; other site 861360009473 phosphate binding motif [ion binding]; other site 861360009474 NAD binding pocket [chemical binding]; other site 861360009475 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 861360009476 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 861360009477 intersubunit interface [polypeptide binding]; other site 861360009478 enterobactin exporter EntS; Provisional; Region: PRK10489 861360009479 MbtH-like protein; Region: MbtH; pfam03621 861360009480 Condensation domain; Region: Condensation; pfam00668 861360009481 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 861360009482 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 861360009483 acyl-activating enzyme (AAE) consensus motif; other site 861360009484 AMP binding site [chemical binding]; other site 861360009485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 861360009486 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 861360009487 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 861360009488 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 861360009489 acyl-activating enzyme (AAE) consensus motif; other site 861360009490 AMP binding site [chemical binding]; other site 861360009491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 861360009492 Condensation domain; Region: Condensation; pfam00668 861360009493 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 861360009494 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 861360009495 Condensation domain; Region: Condensation; pfam00668 861360009496 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 861360009497 peptide synthase; Provisional; Region: PRK12316 861360009498 Condensation domain; Region: Condensation; pfam00668 861360009499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 861360009500 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 861360009501 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 861360009502 acyl-activating enzyme (AAE) consensus motif; other site 861360009503 AMP binding site [chemical binding]; other site 861360009504 Phosphopantetheine attachment site; Region: PP-binding; cl09936 861360009505 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 861360009506 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 861360009507 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 861360009508 acyl-activating enzyme (AAE) consensus motif; other site 861360009509 active site 861360009510 AMP binding site [chemical binding]; other site 861360009511 substrate binding site [chemical binding]; other site 861360009512 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 861360009513 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 861360009514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009515 NAD(P) binding site [chemical binding]; other site 861360009516 active site 861360009517 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 861360009518 Isochorismatase family; Region: Isochorismatase; pfam00857 861360009519 catalytic triad [active] 861360009520 conserved cis-peptide bond; other site 861360009521 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 861360009522 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 861360009523 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 861360009524 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 861360009525 fructuronate transporter; Provisional; Region: PRK10034; cl15264 861360009526 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 861360009527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 861360009528 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 861360009529 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 861360009530 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 861360009531 Sulfate transporter family; Region: Sulfate_transp; pfam00916 861360009532 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 861360009533 Homeodomain-like domain; Region: HTH_23; cl17451 861360009534 Helix-turn-helix domain; Region: HTH_38; pfam13936 861360009535 Integrase core domain; Region: rve; pfam00665 861360009536 Integrase core domain; Region: rve_3; pfam13683 861360009537 AMP-binding domain protein; Validated; Region: PRK08315 861360009538 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 861360009539 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 861360009540 acyl-activating enzyme (AAE) consensus motif; other site 861360009541 acyl-activating enzyme (AAE) consensus motif; other site 861360009542 putative AMP binding site [chemical binding]; other site 861360009543 putative active site [active] 861360009544 putative CoA binding site [chemical binding]; other site 861360009545 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 861360009546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 861360009547 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 861360009548 dimerization interface [polypeptide binding]; other site 861360009549 substrate binding pocket [chemical binding]; other site 861360009550 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 861360009551 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 861360009552 active site 861360009553 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 861360009554 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 861360009555 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 861360009556 active site 861360009557 Domain of unknown function (DUF222); Region: DUF222; pfam02720 861360009558 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 861360009559 active site 861360009560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009561 H+ Antiporter protein; Region: 2A0121; TIGR00900 861360009562 putative substrate translocation pore; other site 861360009563 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 861360009564 Ligand binding site [chemical binding]; other site 861360009565 Electron transfer flavoprotein domain; Region: ETF; pfam01012 861360009566 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 861360009567 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 861360009568 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 861360009569 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 861360009570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 861360009571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 861360009572 S-adenosylmethionine binding site [chemical binding]; other site 861360009573 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 861360009574 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 861360009575 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 861360009576 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 861360009577 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 861360009578 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 861360009579 Transposase; Region: DEDD_Tnp_IS110; pfam01548 861360009580 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 861360009581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 861360009582 Transposase; Region: DDE_Tnp_ISL3; pfam01610 861360009583 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 861360009584 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 861360009585 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 861360009586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 861360009587 ATP binding site [chemical binding]; other site 861360009588 putative Mg++ binding site [ion binding]; other site 861360009589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 861360009590 nucleotide binding region [chemical binding]; other site 861360009591 ATP-binding site [chemical binding]; other site 861360009592 Fic family protein [Function unknown]; Region: COG3177 861360009593 Fic/DOC family; Region: Fic; pfam02661 861360009594 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 861360009595 Mrr N-terminal domain; Region: Mrr_N; pfam14338 861360009596 Restriction endonuclease; Region: Mrr_cat; pfam04471 861360009597 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 861360009598 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 861360009599 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 861360009600 HsdM N-terminal domain; Region: HsdM_N; pfam12161 861360009601 Methyltransferase domain; Region: Methyltransf_26; pfam13659 861360009602 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 861360009603 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 861360009604 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 861360009605 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 861360009606 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 861360009607 hypothetical protein; Provisional; Region: PRK11171 861360009608 Cupin domain; Region: Cupin_2; pfam07883 861360009609 Cupin domain; Region: Cupin_2; pfam07883 861360009610 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 861360009611 malate synthase; Validated; Region: PRK09255 861360009612 malate synthase A; Region: malate_syn_A; TIGR01344 861360009613 active site 861360009614 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 861360009615 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 861360009616 Malic enzyme, N-terminal domain; Region: malic; pfam00390 861360009617 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 861360009618 putative NAD(P) binding site [chemical binding]; other site 861360009619 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 861360009620 Transcriptional regulator [Transcription]; Region: IclR; COG1414 861360009621 Bacterial transcriptional regulator; Region: IclR; pfam01614 861360009622 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 861360009623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 861360009624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 861360009625 Walker A/P-loop; other site 861360009626 ATP binding site [chemical binding]; other site 861360009627 Q-loop/lid; other site 861360009628 ABC transporter signature motif; other site 861360009629 Walker B; other site 861360009630 D-loop; other site 861360009631 H-loop/switch region; other site 861360009632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360009633 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 861360009634 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 861360009635 active site 861360009636 catalytic tetrad [active] 861360009637 Predicted amidohydrolase [General function prediction only]; Region: COG0388 861360009638 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 861360009639 putative active site [active] 861360009640 catalytic triad [active] 861360009641 putative dimer interface [polypeptide binding]; other site 861360009642 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 861360009643 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 861360009644 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 861360009645 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 861360009646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 861360009647 NAD(P) binding site [chemical binding]; other site 861360009648 active site 861360009649 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 861360009650 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 861360009651 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 861360009652 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 861360009653 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 861360009654 dimer interface [polypeptide binding]; other site 861360009655 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 861360009656 active site 861360009657 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 861360009658 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 861360009659 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 861360009660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 861360009661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 861360009662 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 861360009663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 861360009664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 861360009665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360009666 dimer interface [polypeptide binding]; other site 861360009667 conserved gate region; other site 861360009668 putative PBP binding loops; other site 861360009669 ABC-ATPase subunit interface; other site 861360009670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 861360009671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 861360009672 dimer interface [polypeptide binding]; other site 861360009673 conserved gate region; other site 861360009674 putative PBP binding loops; other site 861360009675 ABC-ATPase subunit interface; other site 861360009676 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 861360009677 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 861360009678 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 861360009679 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 861360009680 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 861360009681 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 861360009682 active site 861360009683 catalytic residues [active] 861360009684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 861360009685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 861360009686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 861360009687 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 861360009688 TM-ABC transporter signature motif; other site 861360009689 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 861360009690 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 861360009691 Walker A/P-loop; other site 861360009692 ATP binding site [chemical binding]; other site 861360009693 Q-loop/lid; other site 861360009694 ABC transporter signature motif; other site 861360009695 Walker B; other site 861360009696 D-loop; other site 861360009697 H-loop/switch region; other site 861360009698 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 861360009699 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 861360009700 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 861360009701 putative ligand binding site [chemical binding]; other site 861360009702 L-arabinose isomerase; Provisional; Region: PRK02929 861360009703 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 861360009704 hexamer (dimer of trimers) interface [polypeptide binding]; other site 861360009705 trimer interface [polypeptide binding]; other site 861360009706 substrate binding site [chemical binding]; other site 861360009707 Mn binding site [ion binding]; other site 861360009708 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 861360009709 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 861360009710 intersubunit interface [polypeptide binding]; other site 861360009711 active site 861360009712 Zn2+ binding site [ion binding]; other site 861360009713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 861360009714 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 861360009715 nucleotide binding site [chemical binding]; other site 861360009716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 861360009717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 861360009718 DNA binding site [nucleotide binding] 861360009719 domain linker motif; other site 861360009720 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 861360009721 dimerization interface (open form) [polypeptide binding]; other site 861360009722 ligand binding site [chemical binding]; other site 861360009723 dimerization interface (closed form) [polypeptide binding]; other site 861360009724 xanthine permease; Region: pbuX; TIGR03173 861360009725 urate oxidase; Region: urate_oxi; TIGR03383 861360009726 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 861360009727 active site 861360009728 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 861360009729 active site 861360009730 homotetramer interface [polypeptide binding]; other site 861360009731 OHCU decarboxylase; Region: UraD_2; TIGR03180 861360009732 Cupin domain; Region: Cupin_2; cl17218 861360009733 Predicted permeases [General function prediction only]; Region: COG0679 861360009734 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 861360009735 classical (c) SDRs; Region: SDR_c; cd05233 861360009736 NAD(P) binding site [chemical binding]; other site 861360009737 active site 861360009738 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 861360009739 putative hydrophobic ligand binding site [chemical binding]; other site 861360009740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 861360009741 MarR family; Region: MarR; pfam01047 861360009742 Pirin-related protein [General function prediction only]; Region: COG1741 861360009743 Pirin; Region: Pirin; pfam02678 861360009744 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 861360009745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 861360009746 Coenzyme A binding pocket [chemical binding]; other site 861360009747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 861360009749 putative substrate translocation pore; other site 861360009750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 861360009751 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 861360009752 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 861360009753 active site 861360009754 catalytic site [active] 861360009755 substrate binding site [chemical binding]; other site 861360009756 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 861360009757 replicative DNA helicase; Region: DnaB; TIGR00665 861360009758 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 861360009759 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 861360009760 Walker A motif; other site 861360009761 ATP binding site [chemical binding]; other site 861360009762 Walker B motif; other site 861360009763 DNA binding loops [nucleotide binding] 861360009764 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 861360009765 acyl-CoA synthetase; Validated; Region: PRK08162 861360009766 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 861360009767 acyl-activating enzyme (AAE) consensus motif; other site 861360009768 putative active site [active] 861360009769 AMP binding site [chemical binding]; other site 861360009770 putative CoA binding site [chemical binding]; other site 861360009771 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 861360009772 CoenzymeA binding site [chemical binding]; other site 861360009773 subunit interaction site [polypeptide binding]; other site 861360009774 PHB binding site; other site 861360009775 RibD C-terminal domain; Region: RibD_C; cl17279 861360009776 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 861360009777 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 861360009778 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 861360009779 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 861360009780 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 861360009781 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 861360009782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 861360009783 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 861360009784 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 861360009785 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 861360009786 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 861360009787 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 861360009788 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 861360009789 dimer interface [polypeptide binding]; other site 861360009790 ssDNA binding site [nucleotide binding]; other site 861360009791 tetramer (dimer of dimers) interface [polypeptide binding]; other site 861360009792 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 861360009793 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 861360009794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 861360009795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 861360009796 non-specific DNA binding site [nucleotide binding]; other site 861360009797 salt bridge; other site 861360009798 sequence-specific DNA binding site [nucleotide binding]; other site 861360009799 Protein of unknown function (DUF788); Region: DUF788; pfam05620 861360009800 Tubby C 2; Region: Tub_2; cl02043 861360009801 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 861360009802 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 861360009803 active site 861360009804 metal binding site [ion binding]; metal-binding site 861360009805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 861360009806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 861360009807 active site 861360009808 phosphorylation site [posttranslational modification] 861360009809 intermolecular recognition site; other site 861360009810 dimerization interface [polypeptide binding]; other site 861360009811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 861360009812 DNA binding residues [nucleotide binding] 861360009813 dimerization interface [polypeptide binding]; other site 861360009814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 861360009815 Histidine kinase; Region: HisKA_3; pfam07730 861360009816 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 861360009817 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 861360009818 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 861360009819 Walker A/P-loop; other site 861360009820 ATP binding site [chemical binding]; other site 861360009821 Q-loop/lid; other site 861360009822 ABC transporter signature motif; other site 861360009823 Walker B; other site 861360009824 D-loop; other site 861360009825 H-loop/switch region; other site 861360009826 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 861360009827 putative active site [active] 861360009828 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 861360009829 Predicted integral membrane protein [Function unknown]; Region: COG5650 861360009830 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 861360009831 ligand binding site; other site 861360009832 tetramer interface; other site 861360009833 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 861360009834 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 861360009835 NeuB family; Region: NeuB; pfam03102 861360009836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 861360009837 active site 861360009838 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 861360009839 activation loop (A-loop); other site 861360009840 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 861360009841 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 861360009842 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 861360009843 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 861360009844 active site 861360009845 NTP binding site [chemical binding]; other site 861360009846 metal binding triad [ion binding]; metal-binding site 861360009847 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 861360009848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 861360009849 Zn2+ binding site [ion binding]; other site 861360009850 Mg2+ binding site [ion binding]; other site 861360009851 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 861360009852 active site 861360009853 Ap6A binding site [chemical binding]; other site 861360009854 nudix motif; other site 861360009855 metal binding site [ion binding]; metal-binding site 861360009856 integral membrane protein MviN; Region: mviN; TIGR01695 861360009857 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 861360009858 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 861360009859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 861360009860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 861360009861 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 861360009862 catalytic residues [active] 861360009863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 861360009864 Integrase core domain; Region: rve; pfam00665 861360009865 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 861360009866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 861360009867 Walker A motif; other site 861360009868 ATP binding site [chemical binding]; other site 861360009869 Walker B motif; other site 861360009870 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 861360009871 ParB-like nuclease domain; Region: ParBc; pfam02195 861360009872 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 861360009873 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 861360009874 Magnesium ion binding site [ion binding]; other site 861360009875 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 861360009876 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 861360009877 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 861360009878 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 861360009879 G-X-X-G motif; other site 861360009880 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 861360009881 RxxxH motif; other site 861360009882 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 861360009883 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 861360009884 Haemolytic domain; Region: Haemolytic; cl00506 861360009885 Ribonuclease P; Region: Ribonuclease_P; cl00457 861360009886 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399