-- dump date 20140618_205226 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290340000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 290340000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000003 Walker A motif; other site 290340000004 ATP binding site [chemical binding]; other site 290340000005 Walker B motif; other site 290340000006 arginine finger; other site 290340000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290340000008 DnaA box-binding interface [nucleotide binding]; other site 290340000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 290340000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290340000011 putative DNA binding surface [nucleotide binding]; other site 290340000012 dimer interface [polypeptide binding]; other site 290340000013 beta-clamp/clamp loader binding surface; other site 290340000014 beta-clamp/translesion DNA polymerase binding surface; other site 290340000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 290340000017 recombination protein F; Reviewed; Region: recF; PRK00064 290340000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 290340000019 Walker A/P-loop; other site 290340000020 ATP binding site [chemical binding]; other site 290340000021 Q-loop/lid; other site 290340000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340000023 ABC transporter signature motif; other site 290340000024 Walker B; other site 290340000025 D-loop; other site 290340000026 H-loop/switch region; other site 290340000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 290340000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 290340000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290340000030 anchoring element; other site 290340000031 dimer interface [polypeptide binding]; other site 290340000032 ATP binding site [chemical binding]; other site 290340000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290340000034 active site 290340000035 putative metal-binding site [ion binding]; other site 290340000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290340000037 DNA gyrase subunit A; Validated; Region: PRK05560 290340000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290340000039 CAP-like domain; other site 290340000040 active site 290340000041 primary dimer interface [polypeptide binding]; other site 290340000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 290340000049 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290340000050 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340000051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340000052 active site 290340000053 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 290340000054 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290340000055 active site 290340000056 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 290340000057 Zn2+ binding site [ion binding]; other site 290340000058 Rhomboid family; Region: Rhomboid; pfam01694 290340000059 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 290340000060 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 290340000061 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 290340000062 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290340000063 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 290340000064 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340000065 DNA binding site [nucleotide binding] 290340000066 active site 290340000067 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000069 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340000070 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 290340000071 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340000072 DNA binding site [nucleotide binding] 290340000073 active site 290340000074 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 290340000075 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 290340000076 active site 290340000077 catalytic site [active] 290340000078 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290340000079 Glutamine amidotransferase class-I; Region: GATase; pfam00117 290340000080 glutamine binding [chemical binding]; other site 290340000081 catalytic triad [active] 290340000082 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340000083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340000084 active site 290340000085 ATP binding site [chemical binding]; other site 290340000086 substrate binding site [chemical binding]; other site 290340000087 activation loop (A-loop); other site 290340000088 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000089 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340000091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340000092 active site 290340000093 ATP binding site [chemical binding]; other site 290340000094 substrate binding site [chemical binding]; other site 290340000095 activation loop (A-loop); other site 290340000096 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000097 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340000098 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290340000099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290340000100 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 290340000101 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290340000102 active site 290340000103 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290340000104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340000105 phosphopeptide binding site; other site 290340000106 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 290340000107 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340000108 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290340000109 phosphopeptide binding site; other site 290340000110 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340000111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000112 DNA-binding site [nucleotide binding]; DNA binding site 290340000113 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290340000114 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340000115 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340000116 active site pocket [active] 290340000117 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 290340000118 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 290340000119 mannose binding site [chemical binding]; other site 290340000120 dimerization interface [polypeptide binding]; other site 290340000121 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000122 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290340000123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340000124 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290340000125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340000126 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290340000127 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340000128 Ligand Binding Site [chemical binding]; other site 290340000129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340000130 Ligand Binding Site [chemical binding]; other site 290340000131 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340000132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000133 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340000134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340000135 dimerization interface [polypeptide binding]; other site 290340000136 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340000137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000138 DNA-binding site [nucleotide binding]; DNA binding site 290340000139 FCD domain; Region: FCD; pfam07729 290340000140 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 290340000141 putative active site [active] 290340000142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000143 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340000144 putative substrate translocation pore; other site 290340000145 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 290340000146 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290340000147 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 290340000148 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290340000149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340000150 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290340000151 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340000152 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340000153 carboxyltransferase (CT) interaction site; other site 290340000154 biotinylation site [posttranslational modification]; other site 290340000155 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 290340000156 FAD binding domain; Region: FAD_binding_4; pfam01565 290340000157 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 290340000158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000160 DNA binding site [nucleotide binding] 290340000161 domain linker motif; other site 290340000162 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000163 dimerization interface [polypeptide binding]; other site 290340000164 ligand binding site [chemical binding]; other site 290340000165 Sodium Bile acid symporter family; Region: SBF; pfam01758 290340000166 bile acid transporter; Region: bass; TIGR00841 290340000167 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290340000168 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290340000169 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290340000170 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290340000171 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290340000172 synthetase active site [active] 290340000173 NTP binding site [chemical binding]; other site 290340000174 metal binding site [ion binding]; metal-binding site 290340000175 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290340000176 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340000177 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340000178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340000179 putative substrate binding site [chemical binding]; other site 290340000180 putative ATP binding site [chemical binding]; other site 290340000181 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 290340000182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340000183 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 290340000184 putative dimer interface [polypeptide binding]; other site 290340000185 N-terminal domain interface [polypeptide binding]; other site 290340000186 putative substrate binding pocket (H-site) [chemical binding]; other site 290340000187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290340000189 active site 290340000190 motif I; other site 290340000191 motif II; other site 290340000192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000193 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 290340000194 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340000195 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290340000196 putative NAD(P) binding site [chemical binding]; other site 290340000197 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 290340000198 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 290340000199 putative active site [active] 290340000200 catalytic site [active] 290340000201 putative metal binding site [ion binding]; other site 290340000202 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 290340000203 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290340000204 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 290340000205 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 290340000206 dimerization interface [polypeptide binding]; other site 290340000207 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340000208 NAD binding site [chemical binding]; other site 290340000209 ligand binding site [chemical binding]; other site 290340000210 catalytic site [active] 290340000211 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290340000212 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 290340000213 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 290340000214 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340000215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000216 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340000217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340000219 putative substrate translocation pore; other site 290340000220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340000221 putative DNA binding site [nucleotide binding]; other site 290340000222 RibD C-terminal domain; Region: RibD_C; cl17279 290340000223 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340000224 Family description; Region: VCBS; pfam13517 290340000225 Family description; Region: VCBS; pfam13517 290340000226 Family description; Region: VCBS; pfam13517 290340000227 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 290340000228 intracellular protease, PfpI family; Region: PfpI; TIGR01382 290340000229 proposed catalytic triad [active] 290340000230 conserved cys residue [active] 290340000231 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340000232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340000233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000235 DNA binding site [nucleotide binding] 290340000236 domain linker motif; other site 290340000237 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 290340000238 putative dimerization interface [polypeptide binding]; other site 290340000239 putative ligand binding site [chemical binding]; other site 290340000240 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290340000241 beta-galactosidase; Region: BGL; TIGR03356 290340000242 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340000243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000244 dimer interface [polypeptide binding]; other site 290340000245 conserved gate region; other site 290340000246 putative PBP binding loops; other site 290340000247 ABC-ATPase subunit interface; other site 290340000248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000249 dimer interface [polypeptide binding]; other site 290340000250 conserved gate region; other site 290340000251 ABC-ATPase subunit interface; other site 290340000252 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340000253 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 290340000254 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 290340000255 active site 290340000256 S-layer homology domain; Region: SLH; pfam00395 290340000257 S-layer homology domain; Region: SLH; pfam00395 290340000258 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 290340000259 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 290340000260 OpgC protein; Region: OpgC_C; pfam10129 290340000261 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340000262 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 290340000263 putative FMN binding site [chemical binding]; other site 290340000264 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 290340000265 phosphoglucomutase; Validated; Region: PRK07564 290340000266 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 290340000267 active site 290340000268 substrate binding site [chemical binding]; other site 290340000269 metal binding site [ion binding]; metal-binding site 290340000270 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 290340000271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000272 NAD(P) binding site [chemical binding]; other site 290340000273 active site 290340000274 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 290340000275 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 290340000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000277 POT family; Region: PTR2; cl17359 290340000278 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 290340000279 active site pocket [active] 290340000280 oxyanion hole [active] 290340000281 catalytic triad [active] 290340000282 active site nucleophile [active] 290340000283 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340000284 active site residue [active] 290340000285 prephenate dehydratase; Provisional; Region: PRK11898 290340000286 Prephenate dehydratase; Region: PDT; pfam00800 290340000287 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290340000288 putative L-Phe binding site [chemical binding]; other site 290340000289 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340000290 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340000291 seryl-tRNA synthetase; Provisional; Region: PRK05431 290340000292 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290340000293 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 290340000294 dimer interface [polypeptide binding]; other site 290340000295 active site 290340000296 motif 1; other site 290340000297 motif 2; other site 290340000298 motif 3; other site 290340000299 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340000300 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290340000301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000302 active site 290340000303 motif I; other site 290340000304 motif II; other site 290340000305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000306 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340000307 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 290340000308 GAF domain; Region: GAF; cl17456 290340000309 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000310 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 290340000311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000312 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290340000313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 290340000314 DNA binding residues [nucleotide binding] 290340000315 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000316 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290340000317 putative active site [active] 290340000318 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 290340000319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340000320 active site 290340000321 motif I; other site 290340000322 motif II; other site 290340000323 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 290340000324 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290340000325 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000326 putative active site [active] 290340000327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340000328 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340000329 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290340000330 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 290340000331 putative ADP-binding pocket [chemical binding]; other site 290340000332 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290340000333 dimer interface [polypeptide binding]; other site 290340000334 active site 290340000335 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 290340000336 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340000337 substrate binding site [chemical binding]; other site 290340000338 ATP binding site [chemical binding]; other site 290340000339 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290340000340 active site 290340000341 HIGH motif; other site 290340000342 nucleotide binding site [chemical binding]; other site 290340000343 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340000344 classical (c) SDRs; Region: SDR_c; cd05233 290340000345 NAD(P) binding site [chemical binding]; other site 290340000346 active site 290340000347 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290340000348 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290340000349 putative active site [active] 290340000350 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 290340000351 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340000352 substrate binding site [chemical binding]; other site 290340000353 ATP binding site [chemical binding]; other site 290340000354 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290340000355 active site 290340000356 nucleotide binding site [chemical binding]; other site 290340000357 HIGH motif; other site 290340000358 KMSKS motif; other site 290340000359 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340000360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000361 NAD(P) binding site [chemical binding]; other site 290340000362 active site 290340000363 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 290340000364 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 290340000365 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 290340000366 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 290340000367 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 290340000368 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 290340000369 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 290340000370 putative hydrolase; Region: TIGR03624 290340000371 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 290340000372 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290340000373 Ligand Binding Site [chemical binding]; other site 290340000374 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340000375 active site 290340000376 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340000377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000378 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340000379 Walker A motif; other site 290340000380 ATP binding site [chemical binding]; other site 290340000381 Walker B motif; other site 290340000382 arginine finger; other site 290340000383 Peptidase family M41; Region: Peptidase_M41; pfam01434 290340000384 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 290340000385 homodecamer interface [polypeptide binding]; other site 290340000386 GTP cyclohydrolase I; Provisional; Region: PLN03044 290340000387 active site 290340000388 putative catalytic site residues [active] 290340000389 zinc binding site [ion binding]; other site 290340000390 GTP-CH-I/GFRP interaction surface; other site 290340000391 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290340000392 dihydropteroate synthase; Region: DHPS; TIGR01496 290340000393 substrate binding pocket [chemical binding]; other site 290340000394 dimer interface [polypeptide binding]; other site 290340000395 inhibitor binding site; inhibition site 290340000396 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290340000397 homooctamer interface [polypeptide binding]; other site 290340000398 active site 290340000399 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290340000400 catalytic center binding site [active] 290340000401 ATP binding site [chemical binding]; other site 290340000402 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 290340000403 Uncharacterized conserved protein [Function unknown]; Region: COG3402 290340000404 Bacterial PH domain; Region: DUF304; pfam03703 290340000405 Bacterial PH domain; Region: DUF304; pfam03703 290340000406 Bacterial PH domain; Region: DUF304; pfam03703 290340000407 Rossmann-like domain; Region: Rossmann-like; pfam10727 290340000408 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 290340000409 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290340000410 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290340000411 active site 290340000412 ATP-binding site [chemical binding]; other site 290340000413 pantoate-binding site; other site 290340000414 HXXH motif; other site 290340000415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000416 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340000417 putative substrate translocation pore; other site 290340000418 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340000419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340000420 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 290340000421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340000422 dimerization interface [polypeptide binding]; other site 290340000423 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290340000424 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 290340000425 EamA-like transporter family; Region: EamA; pfam00892 290340000426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000427 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340000428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340000429 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290340000430 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290340000431 putative anticodon binding site; other site 290340000432 dimer interface [polypeptide binding]; other site 290340000433 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290340000434 motif 1; other site 290340000435 dimer interface [polypeptide binding]; other site 290340000436 active site 290340000437 motif 2; other site 290340000438 motif 3; other site 290340000439 Lsr2; Region: Lsr2; pfam11774 290340000440 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 290340000441 Clp amino terminal domain; Region: Clp_N; pfam02861 290340000442 Clp amino terminal domain; Region: Clp_N; pfam02861 290340000443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000444 Walker A motif; other site 290340000445 ATP binding site [chemical binding]; other site 290340000446 Walker B motif; other site 290340000447 arginine finger; other site 290340000448 UvrB/uvrC motif; Region: UVR; pfam02151 290340000449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340000450 Walker A motif; other site 290340000451 ATP binding site [chemical binding]; other site 290340000452 Walker B motif; other site 290340000453 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290340000454 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 290340000455 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 290340000456 homodimer interface [polypeptide binding]; other site 290340000457 active site 290340000458 TDP-binding site; other site 290340000459 acceptor substrate-binding pocket; other site 290340000460 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290340000461 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340000462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340000463 Coenzyme A binding pocket [chemical binding]; other site 290340000464 FAD binding domain; Region: FAD_binding_4; pfam01565 290340000465 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290340000466 Berberine and berberine like; Region: BBE; pfam08031 290340000467 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 290340000468 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 290340000469 DAK2 domain; Region: Dak2; cl03685 290340000470 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 290340000471 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340000472 dimerization domain swap beta strand [polypeptide binding]; other site 290340000473 regulatory protein interface [polypeptide binding]; other site 290340000474 active site 290340000475 regulatory phosphorylation site [posttranslational modification]; other site 290340000476 CsbD-like; Region: CsbD; cl17424 290340000477 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 290340000478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340000480 active site 290340000481 metal binding site [ion binding]; metal-binding site 290340000482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340000483 putative dimer interface [polypeptide binding]; other site 290340000484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000487 Prophage protein (DUF1660); Region: DUF1660; pfam07874 290340000488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340000489 endonuclease III; Region: ENDO3c; smart00478 290340000490 minor groove reading motif; other site 290340000491 helix-hairpin-helix signature motif; other site 290340000492 substrate binding pocket [chemical binding]; other site 290340000493 active site 290340000494 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 290340000495 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 290340000496 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 290340000497 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 290340000498 allophanate hydrolase; Provisional; Region: PRK08186 290340000499 Amidase; Region: Amidase; cl11426 290340000500 urea carboxylase; Region: urea_carbox; TIGR02712 290340000501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340000502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340000503 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340000504 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 290340000505 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290340000506 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340000507 carboxyltransferase (CT) interaction site; other site 290340000508 biotinylation site [posttranslational modification]; other site 290340000509 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290340000510 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 290340000511 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 290340000512 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290340000513 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 290340000514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340000515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340000516 DNA repair protein RadA; Provisional; Region: PRK11823 290340000517 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290340000518 Walker A motif; other site 290340000519 ATP binding site [chemical binding]; other site 290340000520 Walker B motif; other site 290340000521 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290340000522 Predicted membrane protein [Function unknown]; Region: COG4129 290340000523 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290340000524 PBP superfamily domain; Region: PBP_like_2; cl17296 290340000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000526 conserved gate region; other site 290340000527 putative PBP binding loops; other site 290340000528 ABC-ATPase subunit interface; other site 290340000529 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 290340000530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000531 dimer interface [polypeptide binding]; other site 290340000532 conserved gate region; other site 290340000533 putative PBP binding loops; other site 290340000534 ABC-ATPase subunit interface; other site 290340000535 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 290340000536 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290340000537 Walker A/P-loop; other site 290340000538 ATP binding site [chemical binding]; other site 290340000539 Q-loop/lid; other site 290340000540 ABC transporter signature motif; other site 290340000541 Walker B; other site 290340000542 D-loop; other site 290340000543 H-loop/switch region; other site 290340000544 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290340000545 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290340000546 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 290340000547 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 290340000548 GAF domain; Region: GAF; pfam01590 290340000549 GAF domain; Region: GAF_2; pfam13185 290340000550 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000551 GAF domain; Region: GAF; pfam01590 290340000552 GAF domain; Region: GAF_2; pfam13185 290340000553 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290340000555 GAF domain; Region: GAF; pfam01590 290340000556 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000557 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000559 DNA binding site [nucleotide binding] 290340000560 domain linker motif; other site 290340000561 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000562 dimerization interface [polypeptide binding]; other site 290340000563 ligand binding site [chemical binding]; other site 290340000564 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 290340000565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 290340000566 dimer interface [polypeptide binding]; other site 290340000567 active site 290340000568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340000569 substrate binding site [chemical binding]; other site 290340000570 catalytic residue [active] 290340000571 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 290340000572 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 290340000573 alpha-gamma subunit interface [polypeptide binding]; other site 290340000574 beta-gamma subunit interface [polypeptide binding]; other site 290340000575 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 290340000576 gamma-beta subunit interface [polypeptide binding]; other site 290340000577 alpha-beta subunit interface [polypeptide binding]; other site 290340000578 urease subunit alpha; Reviewed; Region: ureC; PRK13207 290340000579 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 290340000580 subunit interactions [polypeptide binding]; other site 290340000581 active site 290340000582 flap region; other site 290340000583 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 290340000584 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 290340000585 dimer interface [polypeptide binding]; other site 290340000586 catalytic residues [active] 290340000587 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 290340000588 UreF; Region: UreF; pfam01730 290340000589 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340000590 UreD urease accessory protein; Region: UreD; cl00530 290340000591 High-affinity nickel-transport protein; Region: NicO; cl00964 290340000592 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340000593 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340000594 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340000597 DNA binding residues [nucleotide binding] 290340000598 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290340000599 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290340000600 active site 290340000601 catalytic site [active] 290340000602 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290340000603 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290340000604 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 290340000605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000606 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000607 active site 290340000608 catalytic tetrad [active] 290340000609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000610 NAD(P) binding site [chemical binding]; other site 290340000611 active site 290340000612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340000613 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000614 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000615 active site 290340000616 catalytic tetrad [active] 290340000617 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000618 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000619 active site 290340000620 catalytic tetrad [active] 290340000621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340000622 salt bridge; other site 290340000623 non-specific DNA binding site [nucleotide binding]; other site 290340000624 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340000625 sequence-specific DNA binding site [nucleotide binding]; other site 290340000626 Dodecin; Region: Dodecin; pfam07311 290340000627 oxidoreductase; Provisional; Region: PRK12743 290340000628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340000629 NAD(P) binding site [chemical binding]; other site 290340000630 active site 290340000631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340000632 Ligand Binding Site [chemical binding]; other site 290340000633 Pectate lyase; Region: Pec_lyase_C; cl01593 290340000634 putative pectinesterase; Region: PLN02432; cl01911 290340000635 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 290340000636 Amb_all domain; Region: Amb_all; smart00656 290340000637 putative pectinesterase; Region: PLN02432; cl01911 290340000638 Pectinesterase; Region: Pectinesterase; pfam01095 290340000639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000641 dimer interface [polypeptide binding]; other site 290340000642 conserved gate region; other site 290340000643 putative PBP binding loops; other site 290340000644 ABC-ATPase subunit interface; other site 290340000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340000647 dimer interface [polypeptide binding]; other site 290340000648 putative PBP binding loops; other site 290340000649 ABC-ATPase subunit interface; other site 290340000650 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340000651 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 290340000652 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 290340000653 active site 290340000654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000656 DNA binding site [nucleotide binding] 290340000657 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340000658 putative dimerization interface [polypeptide binding]; other site 290340000659 putative ligand binding site [chemical binding]; other site 290340000660 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340000661 PYR/PP interface [polypeptide binding]; other site 290340000662 dimer interface [polypeptide binding]; other site 290340000663 TPP binding site [chemical binding]; other site 290340000664 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290340000665 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340000666 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340000667 TPP-binding site [chemical binding]; other site 290340000668 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 290340000669 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290340000670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340000671 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290340000672 short chain dehydrogenase; Provisional; Region: PRK08265 290340000673 classical (c) SDRs; Region: SDR_c; cd05233 290340000674 NAD(P) binding site [chemical binding]; other site 290340000675 active site 290340000676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000679 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340000680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000681 DNA-binding site [nucleotide binding]; DNA binding site 290340000682 FCD domain; Region: FCD; pfam07729 290340000683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340000684 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 290340000685 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 290340000686 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340000687 putative transporter; Provisional; Region: PRK09821 290340000688 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 290340000689 active site 290340000690 intersubunit interface [polypeptide binding]; other site 290340000691 zinc binding site [ion binding]; other site 290340000692 Na+ binding site [ion binding]; other site 290340000693 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 290340000694 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 290340000695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000696 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340000697 Predicted acetyltransferase [General function prediction only]; Region: COG2388 290340000698 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340000699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340000700 Putative zinc-finger; Region: zf-HC2; pfam13490 290340000701 conserved repeat domain; Region: B_ant_repeat; TIGR01451 290340000702 Domain of unknown function DUF11; Region: DUF11; cl17728 290340000703 Domain of unknown function DUF11; Region: DUF11; cl17728 290340000704 Invertebrate innate immunity transcript family; Region: Innate_immun; pfam12782 290340000705 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 290340000706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340000707 catalytic residue [active] 290340000708 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 290340000709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340000710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340000711 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290340000712 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290340000713 IucA / IucC family; Region: IucA_IucC; pfam04183 290340000714 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290340000715 classical (c) SDRs; Region: SDR_c; cd05233 290340000716 NAD(P) binding site [chemical binding]; other site 290340000717 active site 290340000718 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290340000719 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 290340000720 putative hydrophobic ligand binding site [chemical binding]; other site 290340000721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340000722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340000723 Coenzyme A binding pocket [chemical binding]; other site 290340000724 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 290340000725 putative dimer interface [polypeptide binding]; other site 290340000726 ligand binding site [chemical binding]; other site 290340000727 Zn binding site [ion binding]; other site 290340000728 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 290340000729 EamA-like transporter family; Region: EamA; pfam00892 290340000730 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290340000731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340000732 DNA-binding site [nucleotide binding]; DNA binding site 290340000733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340000734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340000735 homodimer interface [polypeptide binding]; other site 290340000736 catalytic residue [active] 290340000737 proline/glycine betaine transporter; Provisional; Region: PRK10642 290340000738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000739 putative substrate translocation pore; other site 290340000740 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290340000741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340000742 S-adenosylmethionine binding site [chemical binding]; other site 290340000743 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 290340000744 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 290340000745 nucleotide binding site [chemical binding]; other site 290340000746 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 290340000747 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 290340000748 active site 290340000749 DNA binding site [nucleotide binding] 290340000750 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 290340000751 DNA binding site [nucleotide binding] 290340000752 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 290340000753 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 290340000754 putative DNA binding site [nucleotide binding]; other site 290340000755 putative homodimer interface [polypeptide binding]; other site 290340000756 transcription termination factor Rho; Provisional; Region: PRK12678 290340000757 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 290340000758 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290340000759 dimerization interface [polypeptide binding]; other site 290340000760 DPS ferroxidase diiron center [ion binding]; other site 290340000761 ion pore; other site 290340000762 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 290340000763 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 290340000764 active site 290340000765 DNA binding site [nucleotide binding] 290340000766 Int/Topo IB signature motif; other site 290340000767 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340000768 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340000769 dimerization domain swap beta strand [polypeptide binding]; other site 290340000770 regulatory protein interface [polypeptide binding]; other site 290340000771 active site 290340000772 regulatory phosphorylation site [posttranslational modification]; other site 290340000773 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 290340000774 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340000775 active site 290340000776 phosphorylation site [posttranslational modification] 290340000777 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290340000778 active site 290340000779 P-loop; other site 290340000780 phosphorylation site [posttranslational modification] 290340000781 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290340000782 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290340000783 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340000784 putative substrate binding site [chemical binding]; other site 290340000785 putative ATP binding site [chemical binding]; other site 290340000786 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340000787 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290340000788 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340000789 GAF domain; Region: GAF; pfam01590 290340000790 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000791 carboxylate-amine ligase; Provisional; Region: PRK13517 290340000792 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340000793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000794 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340000795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340000796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340000797 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 290340000798 Serine hydrolase (FSH1); Region: FSH1; pfam03959 290340000799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340000800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340000801 DNA binding site [nucleotide binding] 290340000802 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340000803 dimerization interface [polypeptide binding]; other site 290340000804 ligand binding site [chemical binding]; other site 290340000805 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290340000806 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290340000807 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290340000808 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290340000809 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340000810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340000811 putative Zn2+ binding site [ion binding]; other site 290340000812 putative DNA binding site [nucleotide binding]; other site 290340000813 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 290340000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340000815 S-adenosylmethionine binding site [chemical binding]; other site 290340000816 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290340000817 active site 290340000818 dimer interface [polypeptide binding]; other site 290340000819 motif 2; other site 290340000820 motif 3; other site 290340000821 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 290340000822 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340000823 MarR family; Region: MarR; pfam01047 290340000824 prenyltransferase; Reviewed; Region: ubiA; PRK13105 290340000825 UbiA prenyltransferase family; Region: UbiA; pfam01040 290340000826 phytoene desaturase; Region: crtI_fam; TIGR02734 290340000827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340000828 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 290340000829 active site lid residues [active] 290340000830 substrate binding pocket [chemical binding]; other site 290340000831 catalytic residues [active] 290340000832 substrate-Mg2+ binding site; other site 290340000833 aspartate-rich region 1; other site 290340000834 aspartate-rich region 2; other site 290340000835 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340000836 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290340000837 substrate binding pocket [chemical binding]; other site 290340000838 chain length determination region; other site 290340000839 substrate-Mg2+ binding site; other site 290340000840 catalytic residues [active] 290340000841 aspartate-rich region 1; other site 290340000842 active site lid residues [active] 290340000843 aspartate-rich region 2; other site 290340000844 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 290340000845 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 290340000846 active site 290340000847 metal binding site [ion binding]; metal-binding site 290340000848 nudix motif; other site 290340000849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340000850 MarR family; Region: MarR; pfam01047 290340000851 CAAX protease self-immunity; Region: Abi; cl00558 290340000852 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340000853 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 290340000854 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 290340000855 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 290340000856 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340000857 active site 290340000858 catalytic triad [active] 290340000859 oxyanion hole [active] 290340000860 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290340000861 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290340000862 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340000863 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340000864 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 290340000865 Cupin domain; Region: Cupin_2; pfam07883 290340000866 Cupin domain; Region: Cupin_2; cl17218 290340000867 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340000868 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 290340000869 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340000870 benzoate transport; Region: 2A0115; TIGR00895 290340000871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000872 putative substrate translocation pore; other site 290340000873 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290340000874 salicylate hydroxylase; Provisional; Region: PRK08163 290340000875 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 290340000876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340000877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 290340000878 putative substrate binding pocket [chemical binding]; other site 290340000879 putative dimerization interface [polypeptide binding]; other site 290340000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000881 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340000882 putative substrate translocation pore; other site 290340000883 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340000884 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 290340000885 putative active site [active] 290340000886 catalytic triad [active] 290340000887 putative dimer interface [polypeptide binding]; other site 290340000888 Glycoprotein hormone beta chain homologues; Region: GHB_like; cl00070 290340000889 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 290340000890 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 290340000891 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340000892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340000893 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340000894 active site 290340000895 catalytic tetrad [active] 290340000896 CoA binding domain; Region: CoA_binding; smart00881 290340000897 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340000898 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 290340000899 putative NAD(P) binding site [chemical binding]; other site 290340000900 putative substrate binding site [chemical binding]; other site 290340000901 catalytic Zn binding site [ion binding]; other site 290340000902 structural Zn binding site [ion binding]; other site 290340000903 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 290340000904 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340000905 putative active site [active] 290340000906 catalytic triad [active] 290340000907 putative dimer interface [polypeptide binding]; other site 290340000908 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 290340000909 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340000910 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340000911 TM-ABC transporter signature motif; other site 290340000912 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340000913 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340000914 Walker A/P-loop; other site 290340000915 ATP binding site [chemical binding]; other site 290340000916 Q-loop/lid; other site 290340000917 ABC transporter signature motif; other site 290340000918 Walker B; other site 290340000919 D-loop; other site 290340000920 H-loop/switch region; other site 290340000921 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340000922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290340000923 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340000924 ligand binding site [chemical binding]; other site 290340000925 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340000926 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290340000927 putative substrate binding site [chemical binding]; other site 290340000928 putative ATP binding site [chemical binding]; other site 290340000929 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 290340000930 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290340000931 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340000932 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 290340000933 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 290340000934 putative N- and C-terminal domain interface [polypeptide binding]; other site 290340000935 putative active site [active] 290340000936 putative MgATP binding site [chemical binding]; other site 290340000937 catalytic site [active] 290340000938 metal binding site [ion binding]; metal-binding site 290340000939 putative carbohydrate binding site [chemical binding]; other site 290340000940 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290340000941 intersubunit interface [polypeptide binding]; other site 290340000942 active site 290340000943 zinc binding site [ion binding]; other site 290340000944 Na+ binding site [ion binding]; other site 290340000945 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340000946 active site 290340000947 catalytic residues [active] 290340000948 Helix-turn-helix domain; Region: HTH_31; pfam13560 290340000949 sequence-specific DNA binding site [nucleotide binding]; other site 290340000950 salt bridge; other site 290340000951 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 290340000952 thiamine pyrophosphate protein; Provisional; Region: PRK08273 290340000953 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290340000954 PYR/PP interface [polypeptide binding]; other site 290340000955 dimer interface [polypeptide binding]; other site 290340000956 tetramer interface [polypeptide binding]; other site 290340000957 TPP binding site [chemical binding]; other site 290340000958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340000959 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340000960 TPP-binding site [chemical binding]; other site 290340000961 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340000962 META domain; Region: META; cl01245 290340000963 glutaminase; Reviewed; Region: PRK12356 290340000964 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290340000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340000966 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340000967 putative substrate translocation pore; other site 290340000968 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 290340000969 putative active site [active] 290340000970 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 290340000971 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340000972 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 290340000973 putative dimer interface [polypeptide binding]; other site 290340000974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340000975 Protein of unknown function (DUF445); Region: DUF445; pfam04286 290340000976 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 290340000977 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290340000978 active site 290340000979 catalytic site [active] 290340000980 AzlC protein; Region: AzlC; pfam03591 290340000981 Domain of unknown function DUF77; Region: DUF77; pfam01910 290340000982 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340000983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340000984 S-adenosylmethionine binding site [chemical binding]; other site 290340000985 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340000986 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340000987 Coenzyme A binding pocket [chemical binding]; other site 290340000988 Cupin superfamily protein; Region: Cupin_4; pfam08007 290340000989 Cupin-like domain; Region: Cupin_8; pfam13621 290340000990 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340000991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290340000992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340000993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340000994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340000995 Walker A/P-loop; other site 290340000996 ATP binding site [chemical binding]; other site 290340000997 Q-loop/lid; other site 290340000998 ABC transporter signature motif; other site 290340000999 Walker B; other site 290340001000 D-loop; other site 290340001001 H-loop/switch region; other site 290340001002 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340001003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340001004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340001005 Q-loop/lid; other site 290340001006 ABC transporter signature motif; other site 290340001007 Walker B; other site 290340001008 D-loop; other site 290340001009 H-loop/switch region; other site 290340001010 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340001011 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340001012 FAD binding pocket [chemical binding]; other site 290340001013 FAD binding motif [chemical binding]; other site 290340001014 phosphate binding motif [ion binding]; other site 290340001015 NAD binding pocket [chemical binding]; other site 290340001016 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340001017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001018 ABC-ATPase subunit interface; other site 290340001019 dimer interface [polypeptide binding]; other site 290340001020 putative PBP binding regions; other site 290340001021 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290340001022 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001023 ABC-ATPase subunit interface; other site 290340001024 dimer interface [polypeptide binding]; other site 290340001025 putative PBP binding regions; other site 290340001026 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340001027 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340001028 Walker A/P-loop; other site 290340001029 ATP binding site [chemical binding]; other site 290340001030 Q-loop/lid; other site 290340001031 ABC transporter signature motif; other site 290340001032 Walker B; other site 290340001033 D-loop; other site 290340001034 H-loop/switch region; other site 290340001035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340001037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340001038 dimerization interface [polypeptide binding]; other site 290340001039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001040 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001041 putative substrate translocation pore; other site 290340001042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001043 NAD(P) binding site [chemical binding]; other site 290340001044 active site 290340001045 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340001046 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001047 active site 290340001048 putative proline-specific permease; Provisional; Region: proY; PRK10580 290340001049 Spore germination protein; Region: Spore_permease; cl17796 290340001050 Short repeats of unknown function; Region: ALF; pfam03752 290340001051 Short repeats of unknown function; Region: ALF; pfam03752 290340001052 Short repeats of unknown function; Region: ALF; pfam03752 290340001053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340001054 putative DNA binding site [nucleotide binding]; other site 290340001055 dimerization interface [polypeptide binding]; other site 290340001056 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001057 putative Zn2+ binding site [ion binding]; other site 290340001058 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001059 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340001060 putative hydrophobic ligand binding site [chemical binding]; other site 290340001061 urocanate hydratase; Provisional; Region: PRK05414 290340001062 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290340001063 active sites [active] 290340001064 tetramer interface [polypeptide binding]; other site 290340001065 agmatinase; Region: agmatinase; TIGR01230 290340001066 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 290340001067 putative active site [active] 290340001068 putative metal binding site [ion binding]; other site 290340001069 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340001070 CopC domain; Region: CopC; pfam04234 290340001071 NlpC/P60 family; Region: NLPC_P60; cl17555 290340001072 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 290340001073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001075 Ligand Binding Site [chemical binding]; other site 290340001076 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290340001077 phosphoenolpyruvate synthase; Validated; Region: PRK06241 290340001078 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290340001079 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290340001080 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 290340001081 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001082 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340001083 putative substrate binding site [chemical binding]; other site 290340001084 putative ATP binding site [chemical binding]; other site 290340001085 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290340001086 EamA-like transporter family; Region: EamA; pfam00892 290340001087 EamA-like transporter family; Region: EamA; pfam00892 290340001088 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 290340001089 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340001090 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340001091 catalytic residues [active] 290340001092 catalytic nucleophile [active] 290340001093 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340001094 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340001095 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340001096 Synaptic Site I dimer interface [polypeptide binding]; other site 290340001097 DNA binding site [nucleotide binding] 290340001098 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 290340001099 DNA-binding interface [nucleotide binding]; DNA binding site 290340001100 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 290340001101 nucleotide binding site/active site [active] 290340001102 HIT family signature motif; other site 290340001103 catalytic residue [active] 290340001104 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 290340001105 Abi-like protein; Region: Abi_2; pfam07751 290340001106 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 290340001107 catalytic residues [active] 290340001108 Cutinase; Region: Cutinase; pfam01083 290340001109 von Willebrand factor type A domain; Region: VWA_2; pfam13519 290340001110 metal ion-dependent adhesion site (MIDAS); other site 290340001111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001112 ATP binding site [chemical binding]; other site 290340001113 Mg2+ binding site [ion binding]; other site 290340001114 G-X-G motif; other site 290340001115 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001117 DNA binding residues [nucleotide binding] 290340001118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 290340001121 SnoaL-like domain; Region: SnoaL_2; pfam12680 290340001122 RHS Repeat; Region: RHS_repeat; cl11982 290340001123 RHS Repeat; Region: RHS_repeat; cl11982 290340001124 RHS Repeat; Region: RHS_repeat; pfam05593 290340001125 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 290340001126 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 290340001127 putative active site [active] 290340001128 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340001129 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001130 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340001131 substrate binding site [chemical binding]; other site 290340001132 ATP binding site [chemical binding]; other site 290340001133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001135 DNA binding site [nucleotide binding] 290340001136 domain linker motif; other site 290340001137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001138 dimerization interface [polypeptide binding]; other site 290340001139 ligand binding site [chemical binding]; other site 290340001140 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340001141 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001143 dimer interface [polypeptide binding]; other site 290340001144 conserved gate region; other site 290340001145 putative PBP binding loops; other site 290340001146 ABC-ATPase subunit interface; other site 290340001147 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001149 dimer interface [polypeptide binding]; other site 290340001150 conserved gate region; other site 290340001151 putative PBP binding loops; other site 290340001152 ABC-ATPase subunit interface; other site 290340001153 Asp23 family; Region: Asp23; pfam03780 290340001154 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 290340001155 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 290340001156 active site 290340001157 putative catalytic site [active] 290340001158 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340001159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340001160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 290340001161 DNA binding residues [nucleotide binding] 290340001162 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290340001163 active site 290340001164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340001165 non-specific DNA binding site [nucleotide binding]; other site 290340001166 salt bridge; other site 290340001167 sequence-specific DNA binding site [nucleotide binding]; other site 290340001168 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340001169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340001170 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340001171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001172 dimer interface [polypeptide binding]; other site 290340001173 conserved gate region; other site 290340001174 putative PBP binding loops; other site 290340001175 ABC-ATPase subunit interface; other site 290340001176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001178 dimer interface [polypeptide binding]; other site 290340001179 conserved gate region; other site 290340001180 putative PBP binding loops; other site 290340001181 ABC-ATPase subunit interface; other site 290340001182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 290340001184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001185 dimerization interface [polypeptide binding]; other site 290340001186 ligand binding site [chemical binding]; other site 290340001187 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 290340001188 putative catalytic site [active] 290340001189 putative phosphate binding site [ion binding]; other site 290340001190 active site 290340001191 metal binding site A [ion binding]; metal-binding site 290340001192 DNA binding site [nucleotide binding] 290340001193 putative AP binding site [nucleotide binding]; other site 290340001194 putative metal binding site B [ion binding]; other site 290340001195 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 290340001196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001198 active site 290340001199 phosphorylation site [posttranslational modification] 290340001200 intermolecular recognition site; other site 290340001201 dimerization interface [polypeptide binding]; other site 290340001202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001203 DNA binding residues [nucleotide binding] 290340001204 Histidine kinase; Region: HisKA_3; pfam07730 290340001205 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290340001206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001207 ATP binding site [chemical binding]; other site 290340001208 G-X-G motif; other site 290340001209 Domain of unknown function (DUF336); Region: DUF336; cl01249 290340001210 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290340001211 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290340001212 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290340001213 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 290340001214 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 290340001215 active site 290340001216 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290340001217 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 290340001218 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340001219 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001220 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340001222 Coenzyme A binding pocket [chemical binding]; other site 290340001223 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 290340001224 Fasciclin domain; Region: Fasciclin; pfam02469 290340001225 BCCT family transporter; Region: BCCT; pfam02028 290340001226 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340001227 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340001228 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340001229 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340001230 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340001231 dimer interface [polypeptide binding]; other site 290340001232 putative functional site; other site 290340001233 putative MPT binding site; other site 290340001234 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 290340001235 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 290340001236 NAD binding site [chemical binding]; other site 290340001237 catalytic Zn binding site [ion binding]; other site 290340001238 structural Zn binding site [ion binding]; other site 290340001239 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340001240 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340001241 putative molybdopterin cofactor binding site [chemical binding]; other site 290340001242 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340001243 putative molybdopterin cofactor binding site; other site 290340001244 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290340001245 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 290340001246 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290340001247 homodimer interface [polypeptide binding]; other site 290340001248 NADP binding site [chemical binding]; other site 290340001249 substrate binding site [chemical binding]; other site 290340001250 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 290340001251 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340001252 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340001253 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 290340001254 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340001255 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340001256 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340001257 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340001258 putative active site [active] 290340001259 putative substrate binding site [chemical binding]; other site 290340001260 putative cosubstrate binding site; other site 290340001261 catalytic site [active] 290340001262 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340001263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340001264 DNA-binding site [nucleotide binding]; DNA binding site 290340001265 FCD domain; Region: FCD; pfam07729 290340001266 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290340001267 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290340001268 active site 290340001269 multimer interface [polypeptide binding]; other site 290340001270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340001272 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340001273 putative dimerization interface [polypeptide binding]; other site 290340001274 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290340001275 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 290340001276 [2Fe-2S] cluster binding site [ion binding]; other site 290340001277 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 290340001278 putative alpha subunit interface [polypeptide binding]; other site 290340001279 putative active site [active] 290340001280 putative substrate binding site [chemical binding]; other site 290340001281 Fe binding site [ion binding]; other site 290340001282 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290340001283 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340001284 FAD binding pocket [chemical binding]; other site 290340001285 FAD binding motif [chemical binding]; other site 290340001286 phosphate binding motif [ion binding]; other site 290340001287 beta-alpha-beta structure motif; other site 290340001288 NAD binding pocket [chemical binding]; other site 290340001289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340001290 catalytic loop [active] 290340001291 iron binding site [ion binding]; other site 290340001292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001294 DNA binding residues [nucleotide binding] 290340001295 dimerization interface [polypeptide binding]; other site 290340001296 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 290340001297 tetramer interface [polypeptide binding]; other site 290340001298 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290340001299 active site 290340001300 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 290340001301 active site 290340001302 dimer interface [polypeptide binding]; other site 290340001303 magnesium binding site [ion binding]; other site 290340001304 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290340001305 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290340001306 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 290340001307 DNA photolyase; Region: DNA_photolyase; pfam00875 290340001308 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340001309 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290340001310 tetrameric interface [polypeptide binding]; other site 290340001311 NAD binding site [chemical binding]; other site 290340001312 catalytic residues [active] 290340001313 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 290340001314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340001315 substrate binding site [chemical binding]; other site 290340001316 oxyanion hole (OAH) forming residues; other site 290340001317 trimer interface [polypeptide binding]; other site 290340001318 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 290340001319 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340001320 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 290340001321 enoyl-CoA hydratase; Provisional; Region: PRK05862 290340001322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340001323 substrate binding site [chemical binding]; other site 290340001324 oxyanion hole (OAH) forming residues; other site 290340001325 trimer interface [polypeptide binding]; other site 290340001326 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340001327 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 290340001328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001329 Ligand Binding Site [chemical binding]; other site 290340001330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001331 Ligand Binding Site [chemical binding]; other site 290340001332 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001333 active site 290340001334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340001335 MarR family; Region: MarR; pfam01047 290340001336 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290340001337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340001338 acyl-activating enzyme (AAE) consensus motif; other site 290340001339 AMP binding site [chemical binding]; other site 290340001340 active site 290340001341 CoA binding site [chemical binding]; other site 290340001342 acyl-coenzyme A oxidase; Region: PLN02526 290340001343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340001344 active site 290340001345 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 290340001346 choline dehydrogenase; Validated; Region: PRK02106 290340001347 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290340001348 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 290340001349 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001350 tetramerization interface [polypeptide binding]; other site 290340001351 NAD(P) binding site [chemical binding]; other site 290340001352 catalytic residues [active] 290340001353 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 290340001354 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340001355 Moco binding site; other site 290340001356 metal coordination site [ion binding]; other site 290340001357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340001359 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340001360 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 290340001361 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 290340001362 DNA binding residues [nucleotide binding] 290340001363 dimer interface [polypeptide binding]; other site 290340001364 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 290340001365 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340001366 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340001367 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 290340001368 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290340001369 homodimer interface [polypeptide binding]; other site 290340001370 NAD binding pocket [chemical binding]; other site 290340001371 ATP binding pocket [chemical binding]; other site 290340001372 Mg binding site [ion binding]; other site 290340001373 active-site loop [active] 290340001374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001376 DNA binding site [nucleotide binding] 290340001377 domain linker motif; other site 290340001378 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001379 ligand binding site [chemical binding]; other site 290340001380 dimerization interface [polypeptide binding]; other site 290340001381 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340001382 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290340001383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340001384 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290340001385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001386 dimer interface [polypeptide binding]; other site 290340001387 conserved gate region; other site 290340001388 putative PBP binding loops; other site 290340001389 ABC-ATPase subunit interface; other site 290340001390 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001392 dimer interface [polypeptide binding]; other site 290340001393 conserved gate region; other site 290340001394 putative PBP binding loops; other site 290340001395 ABC-ATPase subunit interface; other site 290340001396 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340001397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340001399 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340001400 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340001401 glucuronate isomerase; Reviewed; Region: PRK02925 290340001402 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 290340001403 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290340001404 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290340001405 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290340001406 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290340001407 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 290340001408 putative active site pocket [active] 290340001409 putative metal binding site [ion binding]; other site 290340001410 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290340001411 ATP-binding site [chemical binding]; other site 290340001412 Gluconate-6-phosphate binding site [chemical binding]; other site 290340001413 Shikimate kinase; Region: SKI; pfam01202 290340001414 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 290340001415 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290340001416 putative ligand binding site [chemical binding]; other site 290340001417 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340001418 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340001419 Walker A/P-loop; other site 290340001420 ATP binding site [chemical binding]; other site 290340001421 Q-loop/lid; other site 290340001422 ABC transporter signature motif; other site 290340001423 Walker B; other site 290340001424 D-loop; other site 290340001425 H-loop/switch region; other site 290340001426 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340001427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340001428 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340001429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340001430 TM-ABC transporter signature motif; other site 290340001431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001433 DNA binding site [nucleotide binding] 290340001434 domain linker motif; other site 290340001435 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290340001436 ligand binding site [chemical binding]; other site 290340001437 dimerization interface (open form) [polypeptide binding]; other site 290340001438 dimerization interface (closed form) [polypeptide binding]; other site 290340001439 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 290340001440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340001441 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 290340001442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340001443 Walker A/P-loop; other site 290340001444 ATP binding site [chemical binding]; other site 290340001445 Q-loop/lid; other site 290340001446 ABC transporter signature motif; other site 290340001447 Walker B; other site 290340001448 D-loop; other site 290340001449 H-loop/switch region; other site 290340001450 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 290340001451 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290340001452 Phosphotransferase enzyme family; Region: APH; pfam01636 290340001453 ATP binding site [chemical binding]; other site 290340001454 active site 290340001455 ATP binding site [chemical binding]; other site 290340001456 substrate binding site [chemical binding]; other site 290340001457 Flavoprotein; Region: Flavoprotein; pfam02441 290340001458 Phosphotransferase enzyme family; Region: APH; pfam01636 290340001459 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290340001460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001462 active site 290340001463 phosphorylation site [posttranslational modification] 290340001464 intermolecular recognition site; other site 290340001465 dimerization interface [polypeptide binding]; other site 290340001466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340001467 DNA binding residues [nucleotide binding] 290340001468 dimerization interface [polypeptide binding]; other site 290340001469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340001470 Histidine kinase; Region: HisKA_3; pfam07730 290340001471 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 290340001472 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340001473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340001474 UMP phosphatase; Provisional; Region: PRK10444 290340001475 active site 290340001476 motif I; other site 290340001477 motif II; other site 290340001478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340001479 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 290340001480 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290340001481 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290340001482 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 290340001483 active site 290340001484 intersubunit interface [polypeptide binding]; other site 290340001485 zinc binding site [ion binding]; other site 290340001486 Na+ binding site [ion binding]; other site 290340001487 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 290340001488 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340001489 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340001490 Walker A/P-loop; other site 290340001491 ATP binding site [chemical binding]; other site 290340001492 Q-loop/lid; other site 290340001493 ABC transporter signature motif; other site 290340001494 Walker B; other site 290340001495 D-loop; other site 290340001496 H-loop/switch region; other site 290340001497 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290340001498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001499 ABC-ATPase subunit interface; other site 290340001500 dimer interface [polypeptide binding]; other site 290340001501 putative PBP binding regions; other site 290340001502 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340001503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340001504 ABC-ATPase subunit interface; other site 290340001505 dimer interface [polypeptide binding]; other site 290340001506 putative PBP binding regions; other site 290340001507 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 290340001508 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290340001509 siderophore binding site; other site 290340001510 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 290340001511 ligand binding site [chemical binding]; other site 290340001512 active site 290340001513 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290340001514 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290340001515 GDP-binding site [chemical binding]; other site 290340001516 ACT binding site; other site 290340001517 IMP binding site; other site 290340001518 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 290340001519 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340001520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001521 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 290340001522 Strictosidine synthase; Region: Str_synth; pfam03088 290340001523 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 290340001524 L-aspartate oxidase; Provisional; Region: PRK06175 290340001525 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340001526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340001528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340001529 dimerization interface [polypeptide binding]; other site 290340001530 malate dehydrogenase; Provisional; Region: PRK05442 290340001531 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 290340001532 NAD(P) binding site [chemical binding]; other site 290340001533 dimer interface [polypeptide binding]; other site 290340001534 malate binding site [chemical binding]; other site 290340001535 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 290340001536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340001537 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290340001538 Aspartase; Region: Aspartase; cd01357 290340001539 active sites [active] 290340001540 tetramer interface [polypeptide binding]; other site 290340001541 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 290340001542 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340001543 metal binding site [ion binding]; metal-binding site 290340001544 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 290340001545 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340001546 homotrimer interaction site [polypeptide binding]; other site 290340001547 putative active site [active] 290340001548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340001550 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 290340001551 putative substrate binding pocket [chemical binding]; other site 290340001552 dimerization interface [polypeptide binding]; other site 290340001553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001554 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001555 putative substrate translocation pore; other site 290340001556 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340001557 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340001558 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340001559 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340001560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001561 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 290340001562 NAD(P) binding site [chemical binding]; other site 290340001563 catalytic residues [active] 290340001564 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340001565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001566 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001567 putative substrate translocation pore; other site 290340001568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340001569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290340001570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340001572 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 290340001573 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 290340001574 active site 290340001575 catalytic site [active] 290340001576 Uncharacterized conserved protein [Function unknown]; Region: COG4850 290340001577 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 290340001578 CAAX protease self-immunity; Region: Abi; pfam02517 290340001579 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 290340001580 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 290340001581 active site 290340001582 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290340001583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001584 dimerization interface [polypeptide binding]; other site 290340001585 ligand binding site [chemical binding]; other site 290340001586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340001587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340001588 substrate binding pocket [chemical binding]; other site 290340001589 membrane-bound complex binding site; other site 290340001590 hinge residues; other site 290340001591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340001592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001593 dimer interface [polypeptide binding]; other site 290340001594 conserved gate region; other site 290340001595 putative PBP binding loops; other site 290340001596 ABC-ATPase subunit interface; other site 290340001597 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340001598 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340001599 Walker A/P-loop; other site 290340001600 ATP binding site [chemical binding]; other site 290340001601 Q-loop/lid; other site 290340001602 ABC transporter signature motif; other site 290340001603 Walker B; other site 290340001604 D-loop; other site 290340001605 H-loop/switch region; other site 290340001606 putative oxidoreductase; Provisional; Region: PRK11579 290340001607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340001608 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340001609 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340001610 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340001611 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290340001612 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290340001613 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290340001614 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 290340001615 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 290340001616 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 290340001617 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340001618 active site 290340001619 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340001620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340001621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340001622 DNA binding residues [nucleotide binding] 290340001623 CoA binding domain; Region: CoA_binding; cl17356 290340001624 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290340001625 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 290340001626 NodB motif; other site 290340001627 active site 290340001628 catalytic site [active] 290340001629 metal binding site [ion binding]; metal-binding site 290340001630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 290340001631 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 290340001632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340001633 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001635 dimer interface [polypeptide binding]; other site 290340001636 conserved gate region; other site 290340001637 putative PBP binding loops; other site 290340001638 ABC-ATPase subunit interface; other site 290340001639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001641 dimer interface [polypeptide binding]; other site 290340001642 conserved gate region; other site 290340001643 putative PBP binding loops; other site 290340001644 ABC-ATPase subunit interface; other site 290340001645 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290340001646 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 290340001647 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 290340001648 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 290340001649 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 290340001650 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 290340001651 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340001652 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 290340001653 putative active site [active] 290340001654 catalytic triad [active] 290340001655 putative dimer interface [polypeptide binding]; other site 290340001656 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340001657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001658 putative substrate translocation pore; other site 290340001659 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340001660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340001661 DNA-binding site [nucleotide binding]; DNA binding site 290340001662 FCD domain; Region: FCD; pfam07729 290340001663 Protein of unknown function (DUF503); Region: DUF503; pfam04456 290340001664 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 290340001665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340001666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340001667 metal binding site [ion binding]; metal-binding site 290340001668 active site 290340001669 I-site; other site 290340001670 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340001671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340001672 metal binding site [ion binding]; metal-binding site 290340001673 active site 290340001674 I-site; other site 290340001675 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340001676 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 290340001677 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290340001678 dimerization interface [polypeptide binding]; other site 290340001679 ATP binding site [chemical binding]; other site 290340001680 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 290340001681 dimerization interface [polypeptide binding]; other site 290340001682 ATP binding site [chemical binding]; other site 290340001683 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 290340001684 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290340001685 putative active site [active] 290340001686 catalytic triad [active] 290340001687 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 290340001688 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 290340001689 dinuclear metal binding motif [ion binding]; other site 290340001690 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 290340001691 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 290340001692 putative ligand binding site [chemical binding]; other site 290340001693 putative NAD binding site [chemical binding]; other site 290340001694 catalytic site [active] 290340001695 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290340001696 catalytic site [active] 290340001697 BNR repeat-like domain; Region: BNR_2; pfam13088 290340001698 Asp-box motif; other site 290340001699 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340001700 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290340001701 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 290340001702 active site 290340001703 catalytic triad [active] 290340001704 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 290340001705 PA/protease or protease-like domain interface [polypeptide binding]; other site 290340001706 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290340001707 catalytic residues [active] 290340001708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340001709 MarR family; Region: MarR; pfam01047 290340001710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001711 dimer interface [polypeptide binding]; other site 290340001712 conserved gate region; other site 290340001713 putative PBP binding loops; other site 290340001714 ABC-ATPase subunit interface; other site 290340001715 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290340001716 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290340001717 Walker A/P-loop; other site 290340001718 ATP binding site [chemical binding]; other site 290340001719 Q-loop/lid; other site 290340001720 ABC transporter signature motif; other site 290340001721 Walker B; other site 290340001722 D-loop; other site 290340001723 H-loop/switch region; other site 290340001724 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340001725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001726 dimer interface [polypeptide binding]; other site 290340001727 conserved gate region; other site 290340001728 putative PBP binding loops; other site 290340001729 ABC-ATPase subunit interface; other site 290340001730 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290340001731 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 290340001732 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 290340001733 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340001734 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340001735 active site pocket [active] 290340001736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001737 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 290340001738 NAD(P) binding site [chemical binding]; other site 290340001739 catalytic residues [active] 290340001740 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290340001741 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340001742 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 290340001743 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340001744 active site 290340001745 NAD binding site [chemical binding]; other site 290340001746 metal binding site [ion binding]; metal-binding site 290340001747 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001748 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340001749 tetramerization interface [polypeptide binding]; other site 290340001750 NAD(P) binding site [chemical binding]; other site 290340001751 catalytic residues [active] 290340001752 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340001753 classical (c) SDRs; Region: SDR_c; cd05233 290340001754 NAD(P) binding site [chemical binding]; other site 290340001755 active site 290340001756 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340001757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290340001758 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340001759 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340001760 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290340001761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001762 putative substrate translocation pore; other site 290340001763 aspartate kinase; Reviewed; Region: PRK06635 290340001764 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 290340001765 putative nucleotide binding site [chemical binding]; other site 290340001766 putative catalytic residues [active] 290340001767 putative Mg ion binding site [ion binding]; other site 290340001768 putative aspartate binding site [chemical binding]; other site 290340001769 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 290340001770 putative allosteric regulatory site; other site 290340001771 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 290340001772 putative allosteric regulatory residue; other site 290340001773 Domain of unknown function (DUF427); Region: DUF427; pfam04248 290340001774 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340001775 RibD C-terminal domain; Region: RibD_C; cl17279 290340001776 recombination protein RecR; Reviewed; Region: recR; PRK00076 290340001777 RecR protein; Region: RecR; pfam02132 290340001778 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290340001779 putative active site [active] 290340001780 putative metal-binding site [ion binding]; other site 290340001781 tetramer interface [polypeptide binding]; other site 290340001782 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 290340001783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340001784 Walker A motif; other site 290340001785 ATP binding site [chemical binding]; other site 290340001786 Walker B motif; other site 290340001787 arginine finger; other site 290340001788 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 290340001789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 290340001790 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 290340001791 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340001792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340001793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340001794 putative DNA binding site [nucleotide binding]; other site 290340001795 putative Zn2+ binding site [ion binding]; other site 290340001796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340001797 putative dimerization interface [polypeptide binding]; other site 290340001798 Proline dehydrogenase; Region: Pro_dh; cl03282 290340001799 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340001800 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340001801 NAD(P) binding site [chemical binding]; other site 290340001802 catalytic residues [active] 290340001803 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 290340001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340001806 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340001807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340001808 dimerization interface [polypeptide binding]; other site 290340001809 putative Zn2+ binding site [ion binding]; other site 290340001810 putative DNA binding site [nucleotide binding]; other site 290340001811 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340001812 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340001813 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 290340001814 catalytic residues [active] 290340001815 dimer interface [polypeptide binding]; other site 290340001816 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290340001817 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290340001818 hexamer interface [polypeptide binding]; other site 290340001819 active site 290340001820 metal binding site [ion binding]; metal-binding site 290340001821 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 290340001822 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 290340001823 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340001824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340001826 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001827 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001828 DNA binding site [nucleotide binding] 290340001829 domain linker motif; other site 290340001830 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340001831 dimerization interface [polypeptide binding]; other site 290340001832 ligand binding site [chemical binding]; other site 290340001833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340001834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290340001835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340001836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001837 putative PBP binding loops; other site 290340001838 dimer interface [polypeptide binding]; other site 290340001839 ABC-ATPase subunit interface; other site 290340001840 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001842 dimer interface [polypeptide binding]; other site 290340001843 conserved gate region; other site 290340001844 putative PBP binding loops; other site 290340001845 ABC-ATPase subunit interface; other site 290340001846 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290340001847 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 290340001848 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 290340001849 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 290340001850 catalytic residues [active] 290340001851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340001852 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290340001853 putative ADP-binding pocket [chemical binding]; other site 290340001854 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290340001855 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340001856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340001857 Coenzyme A binding pocket [chemical binding]; other site 290340001858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340001859 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340001860 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340001861 substrate binding [chemical binding]; other site 290340001862 active site 290340001863 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340001864 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340001865 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340001866 putative substrate binding site [chemical binding]; other site 290340001867 putative ATP binding site [chemical binding]; other site 290340001868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340001869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340001870 DNA binding site [nucleotide binding] 290340001871 domain linker motif; other site 290340001872 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340001873 putative dimerization interface [polypeptide binding]; other site 290340001874 putative ligand binding site [chemical binding]; other site 290340001875 Right handed beta helix region; Region: Beta_helix; pfam13229 290340001876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340001877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001878 dimer interface [polypeptide binding]; other site 290340001879 conserved gate region; other site 290340001880 putative PBP binding loops; other site 290340001881 ABC-ATPase subunit interface; other site 290340001882 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340001883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340001884 dimer interface [polypeptide binding]; other site 290340001885 conserved gate region; other site 290340001886 putative PBP binding loops; other site 290340001887 ABC-ATPase subunit interface; other site 290340001888 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340001889 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340001890 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340001891 Ligand Binding Site [chemical binding]; other site 290340001892 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 290340001893 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290340001894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 290340001895 PAS fold; Region: PAS; pfam00989 290340001896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290340001897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001898 ATP binding site [chemical binding]; other site 290340001899 Mg2+ binding site [ion binding]; other site 290340001900 G-X-G motif; other site 290340001901 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001903 active site 290340001904 phosphorylation site [posttranslational modification] 290340001905 intermolecular recognition site; other site 290340001906 dimerization interface [polypeptide binding]; other site 290340001907 HTH domain; Region: HTH_11; pfam08279 290340001908 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290340001909 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 290340001910 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290340001911 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290340001912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340001913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340001914 non-specific DNA binding site [nucleotide binding]; other site 290340001915 salt bridge; other site 290340001916 sequence-specific DNA binding site [nucleotide binding]; other site 290340001917 HipA N-terminal domain; Region: Couple_hipA; cl11853 290340001918 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290340001919 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290340001920 Domain of unknown function (DUF336); Region: DUF336; cl01249 290340001921 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001922 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340001923 translocation protein TolB; Provisional; Region: tolB; PRK02889 290340001924 translocation protein TolB; Provisional; Region: tolB; PRK02889 290340001925 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340001926 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340001927 Metal-binding active site; metal-binding site 290340001928 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290340001929 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001930 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340001931 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340001932 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340001933 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340001934 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340001935 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290340001936 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340001937 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340001938 nucleotide binding site [chemical binding]; other site 290340001939 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340001940 malate synthase A; Region: malate_syn_A; TIGR01344 290340001941 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290340001942 active site 290340001943 isocitrate lyase; Provisional; Region: PRK15063 290340001944 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340001945 tetramer interface [polypeptide binding]; other site 290340001946 active site 290340001947 Mg2+/Mn2+ binding site [ion binding]; other site 290340001948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340001949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340001950 non-specific DNA binding site [nucleotide binding]; other site 290340001951 salt bridge; other site 290340001952 sequence-specific DNA binding site [nucleotide binding]; other site 290340001953 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 290340001954 Domain of unknown function (DUF955); Region: DUF955; pfam06114 290340001955 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 290340001956 reactive center loop; other site 290340001957 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 290340001958 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290340001959 dimer interface [polypeptide binding]; other site 290340001960 substrate binding site [chemical binding]; other site 290340001961 ATP binding site [chemical binding]; other site 290340001962 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 290340001963 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 290340001964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340001965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290340001966 dimerization interface [polypeptide binding]; other site 290340001967 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 290340001968 dimer interface [polypeptide binding]; other site 290340001969 phosphorylation site [posttranslational modification] 290340001970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340001971 ATP binding site [chemical binding]; other site 290340001972 Mg2+ binding site [ion binding]; other site 290340001973 G-X-G motif; other site 290340001974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340001976 active site 290340001977 phosphorylation site [posttranslational modification] 290340001978 intermolecular recognition site; other site 290340001979 dimerization interface [polypeptide binding]; other site 290340001980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340001981 DNA binding site [nucleotide binding] 290340001982 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 290340001983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340001984 putative substrate translocation pore; other site 290340001985 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 290340001986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340001987 TIGR01777 family protein; Region: yfcH 290340001988 NAD(P) binding site [chemical binding]; other site 290340001989 active site 290340001990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340001991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340001992 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 290340001993 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 290340001994 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 290340001995 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340001996 putative hydrophobic ligand binding site [chemical binding]; other site 290340001997 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 290340001998 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340001999 homotrimer interaction site [polypeptide binding]; other site 290340002000 putative active site [active] 290340002001 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340002002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002003 putative substrate translocation pore; other site 290340002004 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340002005 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340002006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002007 putative substrate translocation pore; other site 290340002008 thiamine pyrophosphate protein; Validated; Region: PRK08199 290340002009 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340002010 PYR/PP interface [polypeptide binding]; other site 290340002011 dimer interface [polypeptide binding]; other site 290340002012 TPP binding site [chemical binding]; other site 290340002013 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340002014 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340002015 TPP-binding site [chemical binding]; other site 290340002016 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290340002017 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340002018 tetrameric interface [polypeptide binding]; other site 290340002019 NAD binding site [chemical binding]; other site 290340002020 catalytic residues [active] 290340002021 substrate binding site [chemical binding]; other site 290340002022 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340002023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340002024 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340002025 active site 290340002026 allantoate amidohydrolase; Reviewed; Region: PRK09290 290340002027 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 290340002028 active site 290340002029 metal binding site [ion binding]; metal-binding site 290340002030 dimer interface [polypeptide binding]; other site 290340002031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 290340002032 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340002033 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 290340002034 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 290340002035 Walker A/P-loop; other site 290340002036 ATP binding site [chemical binding]; other site 290340002037 Q-loop/lid; other site 290340002038 ABC transporter signature motif; other site 290340002039 Walker B; other site 290340002040 D-loop; other site 290340002041 H-loop/switch region; other site 290340002042 TOBE domain; Region: TOBE_2; pfam08402 290340002043 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290340002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002045 dimer interface [polypeptide binding]; other site 290340002046 conserved gate region; other site 290340002047 putative PBP binding loops; other site 290340002048 ABC-ATPase subunit interface; other site 290340002049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002050 dimer interface [polypeptide binding]; other site 290340002051 conserved gate region; other site 290340002052 putative PBP binding loops; other site 290340002053 ABC-ATPase subunit interface; other site 290340002054 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340002055 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 290340002056 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 290340002057 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 290340002058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002059 NAD(P) binding site [chemical binding]; other site 290340002060 active site 290340002061 acyl-coenzyme A oxidase; Region: PLN02526 290340002062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340002063 active site 290340002064 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290340002065 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340002066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340002067 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340002068 Putative zinc-finger; Region: zf-HC2; pfam13490 290340002069 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 290340002070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002071 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 290340002072 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340002073 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290340002074 DXD motif; other site 290340002075 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290340002076 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 290340002077 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340002078 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340002079 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 290340002080 ADP-ribose binding site [chemical binding]; other site 290340002081 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 290340002082 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 290340002083 probable active site [active] 290340002084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340002085 putative DNA binding site [nucleotide binding]; other site 290340002086 putative Zn2+ binding site [ion binding]; other site 290340002087 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 290340002088 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290340002089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002090 DNA-binding site [nucleotide binding]; DNA binding site 290340002091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002093 homodimer interface [polypeptide binding]; other site 290340002094 catalytic residue [active] 290340002095 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 290340002096 Predicted membrane protein [Function unknown]; Region: COG2364 290340002097 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 290340002098 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 290340002099 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290340002100 DXD motif; other site 290340002101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340002102 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 290340002103 active site 290340002104 catalytic residues [active] 290340002105 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 290340002106 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 290340002107 putative sugar binding sites [chemical binding]; other site 290340002108 Q-X-W motif; other site 290340002109 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340002110 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 290340002111 putative DNA binding site [nucleotide binding]; other site 290340002112 catalytic residue [active] 290340002113 putative H2TH interface [polypeptide binding]; other site 290340002114 putative catalytic residues [active] 290340002115 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340002116 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290340002117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002118 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 290340002119 ATP binding site [chemical binding]; other site 290340002120 putative Mg++ binding site [ion binding]; other site 290340002121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002122 nucleotide binding region [chemical binding]; other site 290340002123 ATP-binding site [chemical binding]; other site 290340002124 DEAD/H associated; Region: DEAD_assoc; pfam08494 290340002125 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 290340002126 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 290340002127 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 290340002128 putative hydrophobic ligand binding site [chemical binding]; other site 290340002129 Nuclease-related domain; Region: NERD; pfam08378 290340002130 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290340002131 putative NAD(P) binding site [chemical binding]; other site 290340002132 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 290340002133 active site 290340002134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340002135 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340002136 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290340002137 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 290340002138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002139 metal binding site [ion binding]; metal-binding site 290340002140 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340002141 nucleoside/Zn binding site; other site 290340002142 dimer interface [polypeptide binding]; other site 290340002143 catalytic motif [active] 290340002144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340002145 active site 290340002146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290340002147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002148 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290340002149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340002150 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 290340002151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002152 catalytic residue [active] 290340002153 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290340002154 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 290340002155 Ligand binding site; other site 290340002156 Ligand binding site; other site 290340002157 Ligand binding site; other site 290340002158 Putative Catalytic site; other site 290340002159 DXD motif; other site 290340002160 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290340002161 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290340002162 catalytic residue [active] 290340002163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340002164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290340002165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340002166 dimer interface [polypeptide binding]; other site 290340002167 phosphorylation site [posttranslational modification] 290340002168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340002169 ATP binding site [chemical binding]; other site 290340002170 Mg2+ binding site [ion binding]; other site 290340002171 G-X-G motif; other site 290340002172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002174 active site 290340002175 phosphorylation site [posttranslational modification] 290340002176 intermolecular recognition site; other site 290340002177 dimerization interface [polypeptide binding]; other site 290340002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002179 DNA binding site [nucleotide binding] 290340002180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002182 DNA binding site [nucleotide binding] 290340002183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002184 catalytic core [active] 290340002185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340002186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340002187 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340002188 putative dimerization interface [polypeptide binding]; other site 290340002189 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 290340002190 EamA-like transporter family; Region: EamA; pfam00892 290340002191 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290340002192 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340002193 tetrameric interface [polypeptide binding]; other site 290340002194 NAD binding site [chemical binding]; other site 290340002195 catalytic residues [active] 290340002196 substrate binding site [chemical binding]; other site 290340002197 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290340002198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340002199 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290340002200 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340002201 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340002202 active site 290340002203 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290340002204 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340002205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340002206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002207 dimer interface [polypeptide binding]; other site 290340002208 conserved gate region; other site 290340002209 ABC-ATPase subunit interface; other site 290340002210 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290340002211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002212 putative PBP binding loops; other site 290340002213 ABC-ATPase subunit interface; other site 290340002214 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340002215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340002216 Walker A/P-loop; other site 290340002217 ATP binding site [chemical binding]; other site 290340002218 Q-loop/lid; other site 290340002219 ABC transporter signature motif; other site 290340002220 Walker B; other site 290340002221 D-loop; other site 290340002222 H-loop/switch region; other site 290340002223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340002224 Walker A/P-loop; other site 290340002225 ATP binding site [chemical binding]; other site 290340002226 Q-loop/lid; other site 290340002227 ABC transporter signature motif; other site 290340002228 Walker B; other site 290340002229 D-loop; other site 290340002230 H-loop/switch region; other site 290340002231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340002232 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290340002233 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340002234 Predicted membrane protein [Function unknown]; Region: COG1511 290340002235 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 290340002236 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 290340002237 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 290340002238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340002239 Walker A/P-loop; other site 290340002240 ATP binding site [chemical binding]; other site 290340002241 Q-loop/lid; other site 290340002242 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 290340002243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340002244 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340002245 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290340002246 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340002247 active site residue [active] 290340002248 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340002249 active site residue [active] 290340002250 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 290340002251 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 290340002252 putative active site cavity [active] 290340002253 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340002254 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340002255 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340002256 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340002257 inhibitor site; inhibition site 290340002258 active site 290340002259 dimer interface [polypeptide binding]; other site 290340002260 catalytic residue [active] 290340002261 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290340002262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340002263 Walker A/P-loop; other site 290340002264 ATP binding site [chemical binding]; other site 290340002265 Q-loop/lid; other site 290340002266 ABC transporter signature motif; other site 290340002267 Walker B; other site 290340002268 D-loop; other site 290340002269 H-loop/switch region; other site 290340002270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340002271 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290340002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002273 dimer interface [polypeptide binding]; other site 290340002274 conserved gate region; other site 290340002275 putative PBP binding loops; other site 290340002276 ABC-ATPase subunit interface; other site 290340002277 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290340002278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340002279 Walker A/P-loop; other site 290340002280 ATP binding site [chemical binding]; other site 290340002281 Q-loop/lid; other site 290340002282 ABC transporter signature motif; other site 290340002283 Walker B; other site 290340002284 D-loop; other site 290340002285 H-loop/switch region; other site 290340002286 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290340002287 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002289 dimer interface [polypeptide binding]; other site 290340002290 conserved gate region; other site 290340002291 putative PBP binding loops; other site 290340002292 ABC-ATPase subunit interface; other site 290340002293 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340002294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340002295 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340002296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002297 DNA-binding site [nucleotide binding]; DNA binding site 290340002298 FCD domain; Region: FCD; pfam07729 290340002299 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 290340002300 active site 290340002301 substrate-binding site [chemical binding]; other site 290340002302 metal-binding site [ion binding] 290340002303 GTP binding site [chemical binding]; other site 290340002304 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 290340002305 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 290340002306 heme-binding site [chemical binding]; other site 290340002307 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 290340002308 FAD binding pocket [chemical binding]; other site 290340002309 FAD binding motif [chemical binding]; other site 290340002310 phosphate binding motif [ion binding]; other site 290340002311 beta-alpha-beta structure motif; other site 290340002312 NAD binding pocket [chemical binding]; other site 290340002313 Heme binding pocket [chemical binding]; other site 290340002314 Transcriptional regulator; Region: Rrf2; cl17282 290340002315 Rrf2 family protein; Region: rrf2_super; TIGR00738 290340002316 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 290340002317 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290340002318 active site 290340002319 substrate binding site [chemical binding]; other site 290340002320 metal binding site [ion binding]; metal-binding site 290340002321 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 290340002322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002323 ATP binding site [chemical binding]; other site 290340002324 putative Mg++ binding site [ion binding]; other site 290340002325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002326 nucleotide binding region [chemical binding]; other site 290340002327 ATP-binding site [chemical binding]; other site 290340002328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340002329 active site 290340002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340002332 putative substrate translocation pore; other site 290340002333 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 290340002334 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340002335 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 290340002336 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290340002337 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 290340002338 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 290340002339 generic binding surface I; other site 290340002340 generic binding surface II; other site 290340002341 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 290340002342 putative active site [active] 290340002343 putative catalytic site [active] 290340002344 putative Mg binding site IVb [ion binding]; other site 290340002345 putative phosphate binding site [ion binding]; other site 290340002346 putative DNA binding site [nucleotide binding]; other site 290340002347 putative Mg binding site IVa [ion binding]; other site 290340002348 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 290340002349 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 290340002350 putative active site [active] 290340002351 putative metal binding site [ion binding]; other site 290340002352 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290340002353 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340002354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002355 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340002356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340002357 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 290340002358 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 290340002359 NAD(P) binding site [chemical binding]; other site 290340002360 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340002361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340002362 carbon starvation protein A; Provisional; Region: PRK15015 290340002363 Carbon starvation protein CstA; Region: CstA; pfam02554 290340002364 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290340002365 Protein of unknown function (DUF466); Region: DUF466; pfam04328 290340002366 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 290340002367 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340002368 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340002369 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340002370 active site 290340002371 catalytic tetrad [active] 290340002372 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340002373 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340002374 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290340002375 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340002376 AsnC family; Region: AsnC_trans_reg; pfam01037 290340002377 amidase; Provisional; Region: PRK07486 290340002378 Amidase; Region: Amidase; pfam01425 290340002379 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 290340002380 amidohydrolase; Region: amidohydrolases; TIGR01891 290340002381 metal binding site [ion binding]; metal-binding site 290340002382 putative dimer interface [polypeptide binding]; other site 290340002383 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 290340002384 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340002385 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340002386 tetramerization interface [polypeptide binding]; other site 290340002387 NAD(P) binding site [chemical binding]; other site 290340002388 catalytic residues [active] 290340002389 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340002390 TPP-binding site [chemical binding]; other site 290340002391 dimer interface [polypeptide binding]; other site 290340002392 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340002393 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340002394 PYR/PP interface [polypeptide binding]; other site 290340002395 dimer interface [polypeptide binding]; other site 290340002396 TPP binding site [chemical binding]; other site 290340002397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340002398 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340002399 putative substrate binding site [chemical binding]; other site 290340002400 putative ATP binding site [chemical binding]; other site 290340002401 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290340002402 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 290340002403 NAD(P) binding site [chemical binding]; other site 290340002404 active site 290340002405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002406 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340002407 NAD(P) binding site [chemical binding]; other site 290340002408 active site 290340002409 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 290340002410 short chain dehydrogenase; Provisional; Region: PRK06523 290340002411 classical (c) SDRs; Region: SDR_c; cd05233 290340002412 NAD(P) binding site [chemical binding]; other site 290340002413 active site 290340002414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340002416 NAD(P) binding site [chemical binding]; other site 290340002417 active site 290340002418 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290340002419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340002420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340002421 dimerization interface [polypeptide binding]; other site 290340002422 Amidohydrolase; Region: Amidohydro_2; pfam04909 290340002423 NifU-like domain; Region: NifU; cl00484 290340002424 short chain dehydrogenase; Provisional; Region: PRK06114 290340002425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002426 NAD(P) binding site [chemical binding]; other site 290340002427 active site 290340002428 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340002429 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340002430 ligand binding site [chemical binding]; other site 290340002431 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340002432 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340002433 Walker A/P-loop; other site 290340002434 ATP binding site [chemical binding]; other site 290340002435 Q-loop/lid; other site 290340002436 ABC transporter signature motif; other site 290340002437 Walker B; other site 290340002438 D-loop; other site 290340002439 H-loop/switch region; other site 290340002440 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340002441 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340002442 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340002443 TM-ABC transporter signature motif; other site 290340002444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 290340002445 classical (c) SDRs; Region: SDR_c; cd05233 290340002446 NAD(P) binding site [chemical binding]; other site 290340002447 active site 290340002448 short chain dehydrogenase; Provisional; Region: PRK06523 290340002449 classical (c) SDRs; Region: SDR_c; cd05233 290340002450 NAD(P) binding site [chemical binding]; other site 290340002451 active site 290340002452 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 290340002453 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340002454 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340002455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002456 putative substrate translocation pore; other site 290340002457 MarR family; Region: MarR_2; pfam12802 290340002458 GAF domain; Region: GAF; pfam01590 290340002459 GAF domain; Region: GAF_2; pfam13185 290340002460 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340002461 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340002462 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290340002463 potential catalytic triad [active] 290340002464 conserved cys residue [active] 290340002465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340002466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340002467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290340002468 dimerization interface [polypeptide binding]; other site 290340002469 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 290340002470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 290340002471 motif II; other site 290340002472 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 290340002473 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340002474 TAP-like protein; Region: Abhydrolase_4; pfam08386 290340002475 DNA polymerase III subunit delta'; Validated; Region: PRK07940 290340002476 DNA polymerase III subunit delta'; Validated; Region: PRK08485 290340002477 thymidylate kinase; Validated; Region: tmk; PRK00698 290340002478 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290340002479 TMP-binding site; other site 290340002480 ATP-binding site [chemical binding]; other site 290340002481 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 290340002482 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002484 catalytic residue [active] 290340002485 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 290340002486 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002487 catalytic core [active] 290340002488 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 290340002489 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290340002490 PhoU domain; Region: PhoU; pfam01895 290340002491 PhoU domain; Region: PhoU; pfam01895 290340002492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340002493 dimer interface [polypeptide binding]; other site 290340002494 phosphorylation site [posttranslational modification] 290340002495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340002496 ATP binding site [chemical binding]; other site 290340002497 Mg2+ binding site [ion binding]; other site 290340002498 G-X-G motif; other site 290340002499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002501 active site 290340002502 phosphorylation site [posttranslational modification] 290340002503 intermolecular recognition site; other site 290340002504 dimerization interface [polypeptide binding]; other site 290340002505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002506 DNA binding site [nucleotide binding] 290340002507 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 290340002508 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290340002509 substrate binding site; other site 290340002510 dimer interface; other site 290340002511 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 290340002512 homotrimer interaction site [polypeptide binding]; other site 290340002513 zinc binding site [ion binding]; other site 290340002514 CDP-binding sites; other site 290340002515 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290340002516 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340002517 active site 290340002518 HIGH motif; other site 290340002519 nucleotide binding site [chemical binding]; other site 290340002520 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290340002521 active site 290340002522 HIGH motif; other site 290340002523 KMSKS motif; other site 290340002524 tRNA binding surface [nucleotide binding]; other site 290340002525 anticodon binding site; other site 290340002526 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 290340002527 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290340002528 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290340002529 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290340002530 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340002531 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290340002532 putative active site [active] 290340002533 catalytic triad [active] 290340002534 putative dimer interface [polypeptide binding]; other site 290340002535 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290340002536 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290340002537 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290340002538 active site 290340002539 catalytic site [active] 290340002540 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 290340002541 active site 290340002542 barstar interaction site; other site 290340002543 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 290340002544 putative RNAase interaction site [polypeptide binding]; other site 290340002545 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 290340002546 putative homodimer interface [polypeptide binding]; other site 290340002547 putative active site pocket [active] 290340002548 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 290340002549 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 290340002550 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 290340002551 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290340002552 active site 290340002553 homodimer interface [polypeptide binding]; other site 290340002554 catalytic site [active] 290340002555 acceptor binding site [chemical binding]; other site 290340002556 trehalose synthase; Region: treS_nterm; TIGR02456 290340002557 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290340002558 active site 290340002559 catalytic site [active] 290340002560 glycogen branching enzyme; Provisional; Region: PRK14705 290340002561 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 290340002562 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290340002563 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 290340002564 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 290340002565 active site 290340002566 catalytic site [active] 290340002567 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 290340002568 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 290340002569 putative hydrophobic ligand binding site [chemical binding]; other site 290340002570 CLM binding site; other site 290340002571 L1 loop; other site 290340002572 DNA binding site [nucleotide binding] 290340002573 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340002574 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340002575 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340002576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340002577 DNA binding site [nucleotide binding] 290340002578 domain linker motif; other site 290340002579 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340002580 dimerization interface [polypeptide binding]; other site 290340002581 ligand binding site [chemical binding]; other site 290340002582 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290340002583 active site 290340002584 catalytic site [active] 290340002585 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 290340002586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340002587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002588 dimer interface [polypeptide binding]; other site 290340002589 conserved gate region; other site 290340002590 ABC-ATPase subunit interface; other site 290340002591 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340002592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002593 dimer interface [polypeptide binding]; other site 290340002594 conserved gate region; other site 290340002595 putative PBP binding loops; other site 290340002596 ABC-ATPase subunit interface; other site 290340002597 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 290340002598 homodimer interface [polypeptide binding]; other site 290340002599 maltodextrin glucosidase; Provisional; Region: PRK10785 290340002600 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 290340002601 active site 290340002602 homodimer interface [polypeptide binding]; other site 290340002603 catalytic site [active] 290340002604 FAD binding domain; Region: FAD_binding_4; pfam01565 290340002605 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 290340002606 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340002607 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 290340002608 cytosine deaminase; Provisional; Region: PRK05985 290340002609 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340002610 active site 290340002611 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340002612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340002613 DNA-binding site [nucleotide binding]; DNA binding site 290340002614 FCD domain; Region: FCD; pfam07729 290340002615 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 290340002616 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 290340002617 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 290340002618 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 290340002619 active site 290340002620 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290340002621 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290340002622 Walker A/P-loop; other site 290340002623 ATP binding site [chemical binding]; other site 290340002624 Q-loop/lid; other site 290340002625 ABC transporter signature motif; other site 290340002626 Walker B; other site 290340002627 D-loop; other site 290340002628 H-loop/switch region; other site 290340002629 TOBE domain; Region: TOBE; pfam03459 290340002630 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 290340002631 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 290340002632 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 290340002633 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 290340002634 active site 290340002635 homotetramer interface [polypeptide binding]; other site 290340002636 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 290340002637 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 290340002638 catalytic residues [active] 290340002639 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290340002640 putative Zn2+ binding site [ion binding]; other site 290340002641 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 290340002642 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290340002643 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290340002644 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 290340002645 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 290340002646 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340002647 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340002648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340002649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340002650 DNA binding site [nucleotide binding] 290340002651 domain linker motif; other site 290340002652 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340002653 putative ligand binding site [chemical binding]; other site 290340002654 putative dimerization interface [polypeptide binding]; other site 290340002655 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002657 dimer interface [polypeptide binding]; other site 290340002658 conserved gate region; other site 290340002659 putative PBP binding loops; other site 290340002660 ABC-ATPase subunit interface; other site 290340002661 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340002662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002663 dimer interface [polypeptide binding]; other site 290340002664 conserved gate region; other site 290340002665 putative PBP binding loops; other site 290340002666 ABC-ATPase subunit interface; other site 290340002667 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340002668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340002669 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 290340002670 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 290340002671 active site 290340002672 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340002673 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340002674 substrate binding [chemical binding]; other site 290340002675 active site 290340002676 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340002677 RibD C-terminal domain; Region: RibD_C; cl17279 290340002678 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340002679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002680 ATP binding site [chemical binding]; other site 290340002681 putative Mg++ binding site [ion binding]; other site 290340002682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002683 nucleotide binding region [chemical binding]; other site 290340002684 ATP-binding site [chemical binding]; other site 290340002685 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290340002686 putative substrate binding site [chemical binding]; other site 290340002687 putative ATP binding site [chemical binding]; other site 290340002688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340002689 catalytic core [active] 290340002690 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290340002691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340002692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340002693 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340002694 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 290340002695 Protein of unknown function DUF72; Region: DUF72; pfam01904 290340002696 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340002697 MarR family; Region: MarR; pfam01047 290340002698 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340002699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340002700 NAD(P) binding site [chemical binding]; other site 290340002701 active site 290340002702 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 290340002703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 290340002704 active site 290340002705 acyl-coenzyme A oxidase; Region: PLN02526 290340002706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340002707 active site 290340002708 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 290340002709 putative active site [active] 290340002710 putative catalytic site [active] 290340002711 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002713 putative substrate translocation pore; other site 290340002714 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 290340002715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340002716 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 290340002717 acyl-activating enzyme (AAE) consensus motif; other site 290340002718 putative AMP binding site [chemical binding]; other site 290340002719 putative active site [active] 290340002720 putative CoA binding site [chemical binding]; other site 290340002721 Protein of unknown function (DUF805); Region: DUF805; pfam05656 290340002722 Predicted dehydrogenase [General function prediction only]; Region: COG0579 290340002723 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340002724 CAAX protease self-immunity; Region: Abi; pfam02517 290340002725 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340002726 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340002727 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 290340002728 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 290340002729 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340002730 active site 290340002731 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340002732 active site 290340002733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002734 sequence-specific DNA binding site [nucleotide binding]; other site 290340002735 salt bridge; other site 290340002736 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340002737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002738 non-specific DNA binding site [nucleotide binding]; other site 290340002739 salt bridge; other site 290340002740 sequence-specific DNA binding site [nucleotide binding]; other site 290340002741 Cupin domain; Region: Cupin_2; pfam07883 290340002742 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290340002743 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340002744 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 290340002745 metal binding site [ion binding]; metal-binding site 290340002746 putative dimer interface [polypeptide binding]; other site 290340002747 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 290340002748 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 290340002749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002750 putative substrate translocation pore; other site 290340002751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340002752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340002753 glycine dehydrogenase; Provisional; Region: PRK05367 290340002754 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340002755 tetramer interface [polypeptide binding]; other site 290340002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002757 catalytic residue [active] 290340002758 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340002759 tetramer interface [polypeptide binding]; other site 290340002760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340002761 catalytic residue [active] 290340002762 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290340002763 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340002764 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340002765 lipoyl attachment site [posttranslational modification]; other site 290340002766 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340002767 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340002768 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290340002769 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 290340002770 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 290340002771 active site 290340002772 substrate binding site [chemical binding]; other site 290340002773 Mg2+ binding site [ion binding]; other site 290340002774 FemAB family; Region: FemAB; pfam02388 290340002775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 290340002776 FemAB family; Region: FemAB; pfam02388 290340002777 FemAB family; Region: FemAB; pfam02388 290340002778 Uncharacterized conserved protein [Function unknown]; Region: COG2966 290340002779 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 290340002780 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340002781 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340002782 FAD binding pocket [chemical binding]; other site 290340002783 FAD binding motif [chemical binding]; other site 290340002784 phosphate binding motif [ion binding]; other site 290340002785 NAD binding pocket [chemical binding]; other site 290340002786 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 290340002787 ligand binding site [chemical binding]; other site 290340002788 active site 290340002789 UGI interface [polypeptide binding]; other site 290340002790 catalytic site [active] 290340002791 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 290340002792 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340002793 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290340002794 DNA-binding site [nucleotide binding]; DNA binding site 290340002795 RNA-binding motif; other site 290340002796 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290340002797 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290340002798 ring oligomerisation interface [polypeptide binding]; other site 290340002799 ATP/Mg binding site [chemical binding]; other site 290340002800 stacking interactions; other site 290340002801 hinge regions; other site 290340002802 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290340002803 RNA/DNA hybrid binding site [nucleotide binding]; other site 290340002804 active site 290340002805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 290340002806 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 290340002807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340002809 active site 290340002810 phosphorylation site [posttranslational modification] 290340002811 intermolecular recognition site; other site 290340002812 dimerization interface [polypeptide binding]; other site 290340002813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340002814 DNA binding site [nucleotide binding] 290340002815 Lysine efflux permease [General function prediction only]; Region: COG1279 290340002816 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 290340002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340002818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340002819 dimerization interface [polypeptide binding]; other site 290340002820 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340002821 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290340002822 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290340002823 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290340002824 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290340002825 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 290340002826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340002827 ATP binding site [chemical binding]; other site 290340002828 putative Mg++ binding site [ion binding]; other site 290340002829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340002830 nucleotide binding region [chemical binding]; other site 290340002831 ATP-binding site [chemical binding]; other site 290340002832 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290340002833 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290340002834 DNA-binding site [nucleotide binding]; DNA binding site 290340002835 RNA-binding motif; other site 290340002836 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 290340002837 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340002838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002839 putative substrate translocation pore; other site 290340002840 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340002841 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340002842 catalytic residue [active] 290340002843 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290340002844 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290340002845 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340002846 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 290340002847 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340002848 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340002849 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290340002850 NlpC/P60 family; Region: NLPC_P60; cl17555 290340002851 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 290340002852 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340002853 active site 290340002854 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290340002855 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 290340002856 GTP binding site; other site 290340002857 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340002858 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340002859 dimer interface [polypeptide binding]; other site 290340002860 putative functional site; other site 290340002861 putative MPT binding site; other site 290340002862 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340002863 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340002864 putative molybdopterin cofactor binding site [chemical binding]; other site 290340002865 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340002866 putative molybdopterin cofactor binding site; other site 290340002867 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 290340002868 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 290340002869 active site 290340002870 catalytic site [active] 290340002871 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 290340002872 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 290340002873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340002874 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340002875 Walker A/P-loop; other site 290340002876 ATP binding site [chemical binding]; other site 290340002877 Q-loop/lid; other site 290340002878 ABC transporter signature motif; other site 290340002879 Walker B; other site 290340002880 D-loop; other site 290340002881 H-loop/switch region; other site 290340002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340002883 dimer interface [polypeptide binding]; other site 290340002884 conserved gate region; other site 290340002885 putative PBP binding loops; other site 290340002886 ABC-ATPase subunit interface; other site 290340002887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340002888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340002889 substrate binding pocket [chemical binding]; other site 290340002890 membrane-bound complex binding site; other site 290340002891 hinge residues; other site 290340002892 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340002893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340002894 Walker A/P-loop; other site 290340002895 ATP binding site [chemical binding]; other site 290340002896 Q-loop/lid; other site 290340002897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340002898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340002899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340002901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340002902 Walker A/P-loop; other site 290340002903 ATP binding site [chemical binding]; other site 290340002904 Q-loop/lid; other site 290340002905 ABC transporter signature motif; other site 290340002906 Walker B; other site 290340002907 D-loop; other site 290340002908 H-loop/switch region; other site 290340002909 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 290340002910 nudix motif; other site 290340002911 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 290340002912 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290340002913 active site 290340002914 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 290340002915 Part of AAA domain; Region: AAA_19; pfam13245 290340002916 Family description; Region: UvrD_C_2; pfam13538 290340002917 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290340002918 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290340002919 CoA-ligase; Region: Ligase_CoA; pfam00549 290340002920 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290340002921 CoA binding domain; Region: CoA_binding; smart00881 290340002922 CoA binding domain; Region: CoA_binding; cl17356 290340002923 CoA-ligase; Region: Ligase_CoA; pfam00549 290340002924 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 290340002925 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 290340002926 Fn3 associated; Region: Fn3_assoc; pfam13287 290340002927 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 290340002928 Fn3 associated; Region: Fn3_assoc; pfam13287 290340002929 Family description; Region: VCBS; pfam13517 290340002930 Family description; Region: VCBS; pfam13517 290340002931 Family description; Region: VCBS; pfam13517 290340002932 Family description; Region: VCBS; pfam13517 290340002933 Family description; Region: VCBS; pfam13517 290340002934 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340002935 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340002936 catalytic triad [active] 290340002937 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290340002938 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 290340002939 active site 290340002940 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290340002941 diiron binding motif [ion binding]; other site 290340002942 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 290340002943 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 290340002944 Na binding site [ion binding]; other site 290340002945 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340002946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340002947 non-specific DNA binding site [nucleotide binding]; other site 290340002948 salt bridge; other site 290340002949 sequence-specific DNA binding site [nucleotide binding]; other site 290340002950 Cupin domain; Region: Cupin_2; pfam07883 290340002951 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340002952 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340002953 putative active site [active] 290340002954 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340002955 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 290340002956 agmatinase; Region: agmatinase; TIGR01230 290340002957 oligomer interface [polypeptide binding]; other site 290340002958 putative active site [active] 290340002959 Mn binding site [ion binding]; other site 290340002960 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290340002961 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340002962 PYR/PP interface [polypeptide binding]; other site 290340002963 dimer interface [polypeptide binding]; other site 290340002964 TPP binding site [chemical binding]; other site 290340002965 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340002966 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340002967 TPP-binding site [chemical binding]; other site 290340002968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340002969 putative DNA binding site [nucleotide binding]; other site 290340002970 putative Zn2+ binding site [ion binding]; other site 290340002971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340002972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002973 putative substrate translocation pore; other site 290340002974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340002975 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340002977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340002978 Walker A/P-loop; other site 290340002979 ATP binding site [chemical binding]; other site 290340002980 Q-loop/lid; other site 290340002981 ABC transporter signature motif; other site 290340002982 Walker B; other site 290340002983 D-loop; other site 290340002984 H-loop/switch region; other site 290340002985 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340002986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340002987 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290340002988 Walker A/P-loop; other site 290340002989 ATP binding site [chemical binding]; other site 290340002990 Q-loop/lid; other site 290340002991 ABC transporter signature motif; other site 290340002992 Walker B; other site 290340002993 D-loop; other site 290340002994 H-loop/switch region; other site 290340002995 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340002996 active site 290340002997 CutC family; Region: CutC; cl01218 290340002998 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 290340002999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340003000 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340003001 Walker A motif; other site 290340003002 ATP binding site [chemical binding]; other site 290340003003 Walker B motif; other site 290340003004 arginine finger; other site 290340003005 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 290340003006 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340003007 PAS fold; Region: PAS_4; pfam08448 290340003008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340003009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340003010 dimer interface [polypeptide binding]; other site 290340003011 phosphorylation site [posttranslational modification] 290340003012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340003013 ATP binding site [chemical binding]; other site 290340003014 Mg2+ binding site [ion binding]; other site 290340003015 G-X-G motif; other site 290340003016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340003017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340003018 active site 290340003019 phosphorylation site [posttranslational modification] 290340003020 intermolecular recognition site; other site 290340003021 dimerization interface [polypeptide binding]; other site 290340003022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340003023 DNA binding site [nucleotide binding] 290340003024 Ferredoxin [Energy production and conversion]; Region: COG1146 290340003025 4Fe-4S binding domain; Region: Fer4; cl02805 290340003026 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340003027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340003028 NAD(P) binding site [chemical binding]; other site 290340003029 catalytic residues [active] 290340003030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003031 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340003032 NAD(P) binding site [chemical binding]; other site 290340003033 active site 290340003034 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340003035 inhibitor site; inhibition site 290340003036 active site 290340003037 dimer interface [polypeptide binding]; other site 290340003038 catalytic residue [active] 290340003039 enoyl-CoA hydratase; Provisional; Region: PRK06494 290340003040 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340003041 substrate binding site [chemical binding]; other site 290340003042 oxyanion hole (OAH) forming residues; other site 290340003043 trimer interface [polypeptide binding]; other site 290340003044 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340003045 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340003046 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 290340003047 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340003048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003049 putative substrate translocation pore; other site 290340003050 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340003051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340003052 salt bridge; other site 290340003053 non-specific DNA binding site [nucleotide binding]; other site 290340003054 sequence-specific DNA binding site [nucleotide binding]; other site 290340003055 Cupin domain; Region: Cupin_2; pfam07883 290340003056 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290340003057 mismatch recognition site; other site 290340003058 additional DNA contacts [nucleotide binding]; other site 290340003059 active site 290340003060 zinc binding site [ion binding]; other site 290340003061 DNA intercalation site [nucleotide binding]; other site 290340003062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290340003063 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 290340003064 AAA domain; Region: AAA_26; pfam13500 290340003065 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 290340003066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340003067 catalytic residue [active] 290340003068 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340003069 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 290340003070 inhibitor-cofactor binding pocket; inhibition site 290340003071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340003072 catalytic residue [active] 290340003073 biotin synthase; Validated; Region: PRK06256 290340003074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340003075 FeS/SAM binding site; other site 290340003076 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 290340003077 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290340003078 Na binding site [ion binding]; other site 290340003079 CsbD-like; Region: CsbD; pfam05532 290340003080 oxidoreductase; Provisional; Region: PRK06128 290340003081 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290340003082 NAD binding site [chemical binding]; other site 290340003083 metal binding site [ion binding]; metal-binding site 290340003084 active site 290340003085 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290340003086 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340003087 NAD binding site [chemical binding]; other site 290340003088 catalytic Zn binding site [ion binding]; other site 290340003089 structural Zn binding site [ion binding]; other site 290340003090 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340003091 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290340003092 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290340003093 FMN binding site [chemical binding]; other site 290340003094 active site 290340003095 substrate binding site [chemical binding]; other site 290340003096 catalytic residue [active] 290340003097 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340003098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340003099 DNA-binding site [nucleotide binding]; DNA binding site 290340003100 FCD domain; Region: FCD; pfam07729 290340003101 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290340003102 dihydroxyacetone kinase; Provisional; Region: PRK14479 290340003103 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290340003104 DAK2 domain; Region: Dak2; pfam02734 290340003105 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 290340003106 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 290340003107 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290340003108 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340003109 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340003110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003111 NAD(P) binding site [chemical binding]; other site 290340003112 active site 290340003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003115 putative substrate translocation pore; other site 290340003116 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290340003117 substrate binding site [chemical binding]; other site 290340003118 dimer interface [polypeptide binding]; other site 290340003119 catalytic triad [active] 290340003120 triosephosphate isomerase; Provisional; Region: PRK14565 290340003121 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 290340003122 RNase_H superfamily; Region: RNase_H_2; pfam13482 290340003123 Part of AAA domain; Region: AAA_19; pfam13245 290340003124 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290340003125 AAA domain; Region: AAA_12; pfam13087 290340003126 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340003127 nucleoside/Zn binding site; other site 290340003128 dimer interface [polypeptide binding]; other site 290340003129 catalytic motif [active] 290340003130 FOG: CBS domain [General function prediction only]; Region: COG0517 290340003131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 290340003132 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 290340003133 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 290340003134 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 290340003135 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 290340003136 RNA binding site [nucleotide binding]; other site 290340003137 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290340003138 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 290340003139 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290340003140 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 290340003141 active site 290340003142 purine riboside binding site [chemical binding]; other site 290340003143 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290340003144 acylphosphatase; Provisional; Region: PRK14427 290340003145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340003146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340003147 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340003148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003149 NAD(P) binding site [chemical binding]; other site 290340003150 active site 290340003151 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340003152 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290340003153 substrate binding site [chemical binding]; other site 290340003154 dimer interface [polypeptide binding]; other site 290340003155 ATP binding site [chemical binding]; other site 290340003156 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340003157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340003158 DNA-binding site [nucleotide binding]; DNA binding site 290340003159 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290340003160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003161 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340003162 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 290340003163 active site 290340003164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003165 dimerization interface [polypeptide binding]; other site 290340003166 putative DNA binding site [nucleotide binding]; other site 290340003167 putative Zn2+ binding site [ion binding]; other site 290340003168 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 290340003169 putative hydrophobic ligand binding site [chemical binding]; other site 290340003170 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340003171 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 290340003172 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340003173 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340003174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340003175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003176 dimer interface [polypeptide binding]; other site 290340003177 conserved gate region; other site 290340003178 ABC-ATPase subunit interface; other site 290340003179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340003180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003181 dimer interface [polypeptide binding]; other site 290340003182 ABC-ATPase subunit interface; other site 290340003183 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340003184 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340003185 Protein of unknown function, DUF624; Region: DUF624; pfam04854 290340003186 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340003187 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290340003188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340003189 active site 290340003190 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340003191 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340003192 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340003193 active site 290340003194 Protein of unknown function (DUF664); Region: DUF664; pfam04978 290340003195 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003196 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 290340003197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340003198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340003199 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 290340003200 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290340003201 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290340003202 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340003203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340003204 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340003205 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340003206 Cupin; Region: Cupin_1; pfam00190 290340003207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003209 DNA binding site [nucleotide binding] 290340003210 domain linker motif; other site 290340003211 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340003212 putative dimerization interface [polypeptide binding]; other site 290340003213 putative ligand binding site [chemical binding]; other site 290340003214 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290340003215 GAF domain; Region: GAF_2; pfam13185 290340003216 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003219 putative substrate translocation pore; other site 290340003220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340003222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340003223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340003224 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 290340003225 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290340003226 putative NAD(P) binding site [chemical binding]; other site 290340003227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340003228 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 290340003229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340003230 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290340003231 Predicted nucleotidyltransferases [General function prediction only]; Region: COG1708 290340003232 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 290340003233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003234 putative DNA binding site [nucleotide binding]; other site 290340003235 putative Zn2+ binding site [ion binding]; other site 290340003236 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 290340003237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340003238 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340003239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340003240 MarR family; Region: MarR_2; cl17246 290340003241 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290340003242 EamA-like transporter family; Region: EamA; pfam00892 290340003243 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 290340003244 Z1 domain; Region: Z1; pfam10593 290340003245 Uncharacterized conserved protein [Function unknown]; Region: COG1479 290340003246 Protein of unknown function DUF262; Region: DUF262; pfam03235 290340003247 amino acid transporter; Region: 2A0306; TIGR00909 290340003248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003249 NAD(P) binding site [chemical binding]; other site 290340003250 active site 290340003251 TfoX N-terminal domain; Region: TfoX_N; cl17592 290340003252 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 290340003253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340003254 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 290340003255 putative active site [active] 290340003256 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290340003257 DNA-binding site [nucleotide binding]; DNA binding site 290340003258 RNA-binding motif; other site 290340003259 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 290340003260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340003261 Walker A/P-loop; other site 290340003262 ATP binding site [chemical binding]; other site 290340003263 Q-loop/lid; other site 290340003264 ABC transporter signature motif; other site 290340003265 Walker B; other site 290340003266 D-loop; other site 290340003267 H-loop/switch region; other site 290340003268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340003269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003270 DNA binding residues [nucleotide binding] 290340003271 dimerization interface [polypeptide binding]; other site 290340003272 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340003273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003274 multidrug resistance protein MdtH; Provisional; Region: PRK11646 290340003275 putative substrate translocation pore; other site 290340003276 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 290340003277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340003278 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340003279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290340003280 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340003281 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 290340003282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340003283 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 290340003284 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 290340003285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340003286 active site 290340003287 AAA domain; Region: AAA_23; pfam13476 290340003288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340003289 AAA domain; Region: AAA_21; pfam13304 290340003290 Walker A/P-loop; other site 290340003291 ATP binding site [chemical binding]; other site 290340003292 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 290340003293 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340003294 DNA binding residues [nucleotide binding] 290340003295 putative dimer interface [polypeptide binding]; other site 290340003296 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290340003297 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290340003298 putative dimer interface [polypeptide binding]; other site 290340003299 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340003300 HSP70 interaction site [polypeptide binding]; other site 290340003301 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340003302 putative dimer interface [polypeptide binding]; other site 290340003303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 290340003305 putative dimer interface [polypeptide binding]; other site 290340003306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340003307 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290340003308 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290340003309 active site 290340003310 substrate binding site [chemical binding]; other site 290340003311 cosubstrate binding site; other site 290340003312 catalytic site [active] 290340003313 benzoate transport; Region: 2A0115; TIGR00895 290340003314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003315 putative substrate translocation pore; other site 290340003316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003317 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 290340003318 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 290340003319 putative active site [active] 290340003320 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 290340003321 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340003322 putative active site [active] 290340003323 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290340003324 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290340003325 purine monophosphate binding site [chemical binding]; other site 290340003326 dimer interface [polypeptide binding]; other site 290340003327 putative catalytic residues [active] 290340003328 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 290340003329 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 290340003330 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 290340003331 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 290340003332 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 290340003333 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290340003334 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 290340003335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340003336 dimer interface [polypeptide binding]; other site 290340003337 conserved gate region; other site 290340003338 ABC-ATPase subunit interface; other site 290340003339 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 290340003340 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 290340003341 Walker A/P-loop; other site 290340003342 ATP binding site [chemical binding]; other site 290340003343 Q-loop/lid; other site 290340003344 ABC transporter signature motif; other site 290340003345 Walker B; other site 290340003346 D-loop; other site 290340003347 H-loop/switch region; other site 290340003348 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 290340003349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340003350 substrate binding pocket [chemical binding]; other site 290340003351 membrane-bound complex binding site; other site 290340003352 hinge residues; other site 290340003353 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 290340003354 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340003355 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340003356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340003357 DNA-binding site [nucleotide binding]; DNA binding site 290340003358 UTRA domain; Region: UTRA; pfam07702 290340003359 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 290340003360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340003361 motif II; other site 290340003362 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 290340003363 Predicted membrane protein [Function unknown]; Region: COG2259 290340003364 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340003365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290340003366 Walker A/P-loop; other site 290340003367 ATP binding site [chemical binding]; other site 290340003368 Q-loop/lid; other site 290340003369 ABC transporter signature motif; other site 290340003370 Walker B; other site 290340003371 D-loop; other site 290340003372 H-loop/switch region; other site 290340003373 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340003374 FtsX-like permease family; Region: FtsX; pfam02687 290340003375 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 290340003376 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290340003377 putative ligand binding site [chemical binding]; other site 290340003378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003379 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340003380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003381 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340003382 TM-ABC transporter signature motif; other site 290340003383 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340003384 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340003385 Walker A/P-loop; other site 290340003386 ATP binding site [chemical binding]; other site 290340003387 Q-loop/lid; other site 290340003388 ABC transporter signature motif; other site 290340003389 Walker B; other site 290340003390 D-loop; other site 290340003391 H-loop/switch region; other site 290340003392 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340003393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003394 dimerization interface [polypeptide binding]; other site 290340003395 putative DNA binding site [nucleotide binding]; other site 290340003396 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340003397 putative Zn2+ binding site [ion binding]; other site 290340003398 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340003399 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340003400 nucleotide binding site [chemical binding]; other site 290340003401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340003402 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290340003403 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 290340003404 putative active site [active] 290340003405 catalytic triad [active] 290340003406 putative dimer interface [polypeptide binding]; other site 290340003407 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340003408 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 290340003409 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340003410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290340003411 alanine racemase; Reviewed; Region: alr; PRK00053 290340003412 active site 290340003413 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340003414 dimer interface [polypeptide binding]; other site 290340003415 substrate binding site [chemical binding]; other site 290340003416 catalytic residues [active] 290340003417 amino acid transporter; Region: 2A0306; TIGR00909 290340003418 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290340003419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340003420 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290340003421 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340003422 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340003423 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290340003424 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290340003425 trimer interface [polypeptide binding]; other site 290340003426 putative metal binding site [ion binding]; other site 290340003427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340003428 S-adenosylmethionine binding site [chemical binding]; other site 290340003429 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340003430 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340003431 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340003432 putative active site [active] 290340003433 putative substrate binding site [chemical binding]; other site 290340003434 putative cosubstrate binding site; other site 290340003435 catalytic site [active] 290340003436 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340003437 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340003438 dimer interface [polypeptide binding]; other site 290340003439 active site 290340003440 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340003441 folate binding site [chemical binding]; other site 290340003442 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 290340003443 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290340003444 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290340003445 homodimer interface [polypeptide binding]; other site 290340003446 NADP binding site [chemical binding]; other site 290340003447 substrate binding site [chemical binding]; other site 290340003448 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340003449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340003450 Walker A/P-loop; other site 290340003451 ATP binding site [chemical binding]; other site 290340003452 Q-loop/lid; other site 290340003453 ABC transporter signature motif; other site 290340003454 Walker B; other site 290340003455 D-loop; other site 290340003456 H-loop/switch region; other site 290340003457 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290340003458 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290340003459 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290340003460 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290340003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003463 putative substrate translocation pore; other site 290340003464 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 290340003465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003467 DNA binding site [nucleotide binding] 290340003468 domain linker motif; other site 290340003469 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340003470 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 290340003471 putative active site [active] 290340003472 putative catalytic site [active] 290340003473 putative DNA binding site [nucleotide binding]; other site 290340003474 putative phosphate binding site [ion binding]; other site 290340003475 metal binding site A [ion binding]; metal-binding site 290340003476 putative AP binding site [nucleotide binding]; other site 290340003477 putative metal binding site B [ion binding]; other site 290340003478 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290340003479 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290340003480 active site 290340003481 HIGH motif; other site 290340003482 dimer interface [polypeptide binding]; other site 290340003483 KMSKS motif; other site 290340003484 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290340003485 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 290340003486 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 290340003487 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290340003488 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 290340003489 active site 290340003490 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340003491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340003492 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 290340003493 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290340003494 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 290340003495 L-aspartate oxidase; Provisional; Region: PRK06175 290340003496 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340003497 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 290340003498 putative Iron-sulfur protein interface [polypeptide binding]; other site 290340003499 putative proximal heme binding site [chemical binding]; other site 290340003500 putative SdhC-like subunit interface [polypeptide binding]; other site 290340003501 putative distal heme binding site [chemical binding]; other site 290340003502 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 290340003503 putative Iron-sulfur protein interface [polypeptide binding]; other site 290340003504 putative proximal heme binding site [chemical binding]; other site 290340003505 putative SdhD-like interface [polypeptide binding]; other site 290340003506 putative distal heme binding site [chemical binding]; other site 290340003507 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 290340003508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340003509 active site 290340003510 Cupin domain; Region: Cupin_2; cl17218 290340003511 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340003512 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 290340003513 metal binding site [ion binding]; metal-binding site 290340003514 putative dimer interface [polypeptide binding]; other site 290340003515 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340003516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003517 putative Zn2+ binding site [ion binding]; other site 290340003518 putative DNA binding site [nucleotide binding]; other site 290340003519 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 290340003520 Prostaglandin dehydrogenases; Region: PGDH; cd05288 290340003521 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 290340003522 NAD(P) binding site [chemical binding]; other site 290340003523 substrate binding site [chemical binding]; other site 290340003524 dimer interface [polypeptide binding]; other site 290340003525 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 290340003526 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 290340003527 ligand binding site [chemical binding]; other site 290340003528 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 290340003529 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340003530 Walker A/P-loop; other site 290340003531 ATP binding site [chemical binding]; other site 290340003532 Q-loop/lid; other site 290340003533 ABC transporter signature motif; other site 290340003534 Walker B; other site 290340003535 D-loop; other site 290340003536 H-loop/switch region; other site 290340003537 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340003538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003539 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290340003540 TM-ABC transporter signature motif; other site 290340003541 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003542 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290340003543 TM-ABC transporter signature motif; other site 290340003544 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290340003545 active site 290340003546 catalytic motif [active] 290340003547 Zn binding site [ion binding]; other site 290340003548 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 290340003549 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290340003550 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290340003551 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 290340003552 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340003553 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340003554 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340003555 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340003556 adenosine deaminase; Provisional; Region: PRK09358 290340003557 active site 290340003558 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 290340003559 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 290340003560 homodimer interface [polypeptide binding]; other site 290340003561 metal binding site [ion binding]; metal-binding site 290340003562 enolase; Provisional; Region: eno; PRK00077 290340003563 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290340003564 dimer interface [polypeptide binding]; other site 290340003565 metal binding site [ion binding]; metal-binding site 290340003566 substrate binding pocket [chemical binding]; other site 290340003567 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 290340003568 Septum formation initiator; Region: DivIC; pfam04977 290340003569 Protein of unknown function (DUF501); Region: DUF501; pfam04417 290340003570 exopolyphosphatase; Region: exo_poly_only; TIGR03706 290340003571 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290340003572 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290340003573 active site 290340003574 catalytic residues [active] 290340003575 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290340003576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 290340003578 ACT domain; Region: ACT_3; pfam10000 290340003579 Family description; Region: ACT_7; pfam13840 290340003580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340003581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340003582 Coenzyme A binding pocket [chemical binding]; other site 290340003583 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290340003584 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340003585 putative lipid kinase; Reviewed; Region: PRK13057 290340003586 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340003587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290340003588 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290340003589 Walker A/P-loop; other site 290340003590 ATP binding site [chemical binding]; other site 290340003591 Q-loop/lid; other site 290340003592 ABC transporter signature motif; other site 290340003593 Walker B; other site 290340003594 D-loop; other site 290340003595 H-loop/switch region; other site 290340003596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290340003597 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290340003598 Walker A/P-loop; other site 290340003599 ATP binding site [chemical binding]; other site 290340003600 Q-loop/lid; other site 290340003601 ABC transporter signature motif; other site 290340003602 Walker B; other site 290340003603 D-loop; other site 290340003604 H-loop/switch region; other site 290340003605 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290340003606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003607 TM-ABC transporter signature motif; other site 290340003608 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290340003609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340003610 TM-ABC transporter signature motif; other site 290340003611 Bax inhibitor 1 like; Region: BaxI_1; cl17691 290340003612 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 290340003613 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340003614 dimer interface [polypeptide binding]; other site 290340003615 active site 290340003616 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 290340003617 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 290340003618 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290340003619 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290340003620 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 290340003621 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 290340003622 dimer interface [polypeptide binding]; other site 290340003623 active site 290340003624 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340003625 active site 290340003626 catalytic residues [active] 290340003627 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290340003628 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290340003629 threonine dehydratase; Provisional; Region: PRK08198 290340003630 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290340003631 tetramer interface [polypeptide binding]; other site 290340003632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340003633 catalytic residue [active] 290340003634 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 290340003635 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290340003636 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290340003637 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290340003638 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 290340003639 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290340003640 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 290340003641 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 290340003642 catalytic residues [active] 290340003643 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 290340003644 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 290340003645 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 290340003646 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290340003647 catalytic residue [active] 290340003648 putative FPP diphosphate binding site; other site 290340003649 putative FPP binding hydrophobic cleft; other site 290340003650 dimer interface [polypeptide binding]; other site 290340003651 putative IPP diphosphate binding site; other site 290340003652 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 290340003653 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 290340003654 putative active site [active] 290340003655 PhoH-like protein; Region: PhoH; pfam02562 290340003656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340003657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340003658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 290340003659 nudix motif; other site 290340003660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003662 putative substrate translocation pore; other site 290340003663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003664 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290340003665 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 290340003666 active sites [active] 290340003667 tetramer interface [polypeptide binding]; other site 290340003668 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 290340003669 active site clefts [active] 290340003670 zinc binding site [ion binding]; other site 290340003671 dimer interface [polypeptide binding]; other site 290340003672 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 290340003673 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290340003674 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 290340003675 putative active site [active] 290340003676 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 290340003677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 290340003678 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 290340003679 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290340003680 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290340003681 Transcriptional regulator [Transcription]; Region: LytR; COG1316 290340003682 AIR carboxylase; Region: AIRC; pfam00731 290340003683 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 290340003684 LabA_like proteins; Region: LabA_like/DUF88; cl10034 290340003685 ATP-grasp domain; Region: ATP-grasp; pfam02222 290340003686 Predicted membrane protein [Function unknown]; Region: COG2246 290340003687 GtrA-like protein; Region: GtrA; pfam04138 290340003688 TIGR03089 family protein; Region: TIGR03089 290340003689 Transcription factor WhiB; Region: Whib; pfam02467 290340003690 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340003691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340003692 active site 290340003693 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 290340003694 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 290340003695 Trm112p-like protein; Region: Trm112p; cl01066 290340003696 Adenosylhomocysteinase; Provisional; Region: PTZ00075 290340003697 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 290340003698 homotetramer interface [polypeptide binding]; other site 290340003699 ligand binding site [chemical binding]; other site 290340003700 catalytic site [active] 290340003701 NAD binding site [chemical binding]; other site 290340003702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 290340003703 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 290340003704 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290340003705 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290340003706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290340003707 RDD family; Region: RDD; pfam06271 290340003708 Integral membrane protein DUF95; Region: DUF95; pfam01944 290340003709 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 290340003710 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 290340003711 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290340003712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340003713 catalytic residue [active] 290340003714 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 290340003715 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 290340003716 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290340003717 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290340003718 acyl-activating enzyme (AAE) consensus motif; other site 290340003719 putative AMP binding site [chemical binding]; other site 290340003720 putative active site [active] 290340003721 putative CoA binding site [chemical binding]; other site 290340003722 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 290340003723 Predicted methyltransferases [General function prediction only]; Region: COG0313 290340003724 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 290340003725 putative SAM binding site [chemical binding]; other site 290340003726 putative homodimer interface [polypeptide binding]; other site 290340003727 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340003728 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340003729 tetramerization interface [polypeptide binding]; other site 290340003730 NAD(P) binding site [chemical binding]; other site 290340003731 catalytic residues [active] 290340003732 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290340003733 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290340003734 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 290340003735 Protein of unknown function DUF58; Region: DUF58; pfam01882 290340003736 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340003738 Walker A motif; other site 290340003739 ATP binding site [chemical binding]; other site 290340003740 Walker B motif; other site 290340003741 arginine finger; other site 290340003742 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290340003743 active site 290340003744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 290340003745 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290340003746 G5 domain; Region: G5; pfam07501 290340003747 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 290340003748 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 290340003749 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 290340003750 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 290340003751 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290340003752 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340003753 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340003754 ABC transporter; Region: ABC_tran_2; pfam12848 290340003755 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340003756 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290340003757 dimer interface [polypeptide binding]; other site 290340003758 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 290340003759 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290340003760 Substrate binding site; other site 290340003761 Mg++ binding site; other site 290340003762 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 290340003763 active site 290340003764 substrate binding site [chemical binding]; other site 290340003765 CoA binding site [chemical binding]; other site 290340003766 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290340003767 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 290340003768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340003769 active site 290340003770 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 290340003771 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290340003772 5S rRNA interface [nucleotide binding]; other site 290340003773 CTC domain interface [polypeptide binding]; other site 290340003774 L16 interface [polypeptide binding]; other site 290340003775 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290340003776 putative active site [active] 290340003777 catalytic residue [active] 290340003778 AAA ATPase domain; Region: AAA_16; pfam13191 290340003779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340003780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003781 DNA binding residues [nucleotide binding] 290340003782 dimerization interface [polypeptide binding]; other site 290340003783 AAA ATPase domain; Region: AAA_16; pfam13191 290340003784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340003785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340003786 DNA binding residues [nucleotide binding] 290340003787 AAA ATPase domain; Region: AAA_16; pfam13191 290340003788 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290340003789 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290340003790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340003791 catalytic residue [active] 290340003792 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290340003793 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290340003794 trimerization site [polypeptide binding]; other site 290340003795 active site 290340003796 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 290340003797 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 290340003798 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290340003799 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 290340003800 putative NAD(P) binding site [chemical binding]; other site 290340003801 putative active site [active] 290340003802 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290340003803 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 290340003804 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 290340003805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340003806 ATP binding site [chemical binding]; other site 290340003807 putative Mg++ binding site [ion binding]; other site 290340003808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340003809 nucleotide binding region [chemical binding]; other site 290340003810 ATP-binding site [chemical binding]; other site 290340003811 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 290340003812 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 290340003813 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 290340003814 intersubunit interface [polypeptide binding]; other site 290340003815 active site 290340003816 catalytic residue [active] 290340003817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290340003818 RibD C-terminal domain; Region: RibD_C; cl17279 290340003819 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340003820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340003821 putative DNA binding site [nucleotide binding]; other site 290340003822 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340003823 putative Zn2+ binding site [ion binding]; other site 290340003824 Cation efflux family; Region: Cation_efflux; cl00316 290340003825 Thioredoxin; Region: Thioredoxin_4; pfam13462 290340003826 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340003827 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290340003828 Catalytic site [active] 290340003829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340003830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340003831 DNA binding site [nucleotide binding] 290340003832 domain linker motif; other site 290340003833 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340003834 ligand binding site [chemical binding]; other site 290340003835 dimerization interface [polypeptide binding]; other site 290340003836 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 290340003837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003838 putative substrate translocation pore; other site 290340003839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003840 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340003841 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 290340003842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003843 active site 290340003844 DNA binding site [nucleotide binding] 290340003845 Int/Topo IB signature motif; other site 290340003846 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 290340003847 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003848 active site 290340003849 DNA binding site [nucleotide binding] 290340003850 Int/Topo IB signature motif; other site 290340003851 SH3 domain-containing protein; Provisional; Region: PRK10884 290340003852 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340003853 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290340003854 active site 290340003855 CoA binding site [chemical binding]; other site 290340003856 acyl-activating enzyme (AAE) consensus motif; other site 290340003857 AMP binding site [chemical binding]; other site 290340003858 acetate binding site [chemical binding]; other site 290340003859 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340003860 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340003861 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340003862 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340003863 Protein of unknown function (DUF779); Region: DUF779; pfam05610 290340003864 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340003865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340003866 NAD(P) binding site [chemical binding]; other site 290340003867 catalytic residues [active] 290340003868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340003870 putative substrate translocation pore; other site 290340003871 HTH-like domain; Region: HTH_21; pfam13276 290340003872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340003873 Integrase core domain; Region: rve; pfam00665 290340003874 Integrase core domain; Region: rve_3; pfam13683 290340003875 Transposase; Region: HTH_Tnp_1; pfam01527 290340003876 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 290340003877 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290340003878 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290340003879 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 290340003880 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 290340003881 putative dimer interface [polypeptide binding]; other site 290340003882 ligand binding site [chemical binding]; other site 290340003883 Zn binding site [ion binding]; other site 290340003884 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290340003885 active site 290340003886 catalytic residues [active] 290340003887 DNA binding site [nucleotide binding] 290340003888 Int/Topo IB signature motif; other site 290340003889 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 290340003890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340003891 DNA binding site [nucleotide binding] 290340003892 active site 290340003893 Int/Topo IB signature motif; other site 290340003894 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290340003895 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290340003896 active site 290340003897 DNA binding site [nucleotide binding] 290340003898 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290340003899 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 290340003900 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290340003901 active site 290340003902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290340003903 DNA binding site [nucleotide binding] 290340003904 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290340003905 active site 290340003906 SAM binding site [chemical binding]; other site 290340003907 homodimer interface [polypeptide binding]; other site 290340003908 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290340003909 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290340003910 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290340003911 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290340003912 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290340003913 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 290340003914 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 290340003915 active site 290340003916 substrate binding site [chemical binding]; other site 290340003917 metal binding site [ion binding]; metal-binding site 290340003918 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340003919 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340003920 substrate binding [chemical binding]; other site 290340003921 active site 290340003922 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340003923 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 290340003924 active site 290340003925 purine nucleoside phosphorylase; Provisional; Region: PRK08202 290340003926 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 290340003927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340003929 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340003930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340003931 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290340003932 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290340003933 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290340003934 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290340003935 [4Fe-4S] binding site [ion binding]; other site 290340003936 molybdopterin cofactor binding site; other site 290340003937 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 290340003938 molybdopterin cofactor binding site; other site 290340003939 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 290340003940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340003941 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340003942 putative substrate translocation pore; other site 290340003943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290340003944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340003945 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290340003946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340003947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340003948 carboxyltransferase (CT) interaction site; other site 290340003949 biotinylation site [posttranslational modification]; other site 290340003950 Maf-like protein; Region: Maf; pfam02545 290340003951 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290340003952 active site 290340003953 dimer interface [polypeptide binding]; other site 290340003954 MMPL family; Region: MMPL; pfam03176 290340003955 MMPL family; Region: MMPL; pfam03176 290340003956 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 290340003957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340003958 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 290340003959 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 290340003960 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290340003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 290340003962 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 290340003963 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 290340003964 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290340003965 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290340003966 short chain dehydrogenase; Provisional; Region: PRK08278 290340003967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340003968 NAD(P) binding site [chemical binding]; other site 290340003969 active site 290340003970 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 290340003971 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 290340003972 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290340003973 Bacterial PH domain; Region: DUF304; pfam03703 290340003974 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 290340003975 cyclase homology domain; Region: CHD; cd07302 290340003976 nucleotidyl binding site; other site 290340003977 metal binding site [ion binding]; metal-binding site 290340003978 dimer interface [polypeptide binding]; other site 290340003979 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003980 Interdomain contacts; other site 290340003981 Cytokine receptor motif; other site 290340003982 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003983 Interdomain contacts; other site 290340003984 Cytokine receptor motif; other site 290340003985 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003986 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003987 Interdomain contacts; other site 290340003988 Cytokine receptor motif; other site 290340003989 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290340003990 Interdomain contacts; other site 290340003991 Cytokine receptor motif; other site 290340003992 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340003993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340003994 Walker A motif; other site 290340003995 ATP binding site [chemical binding]; other site 290340003996 Walker B motif; other site 290340003997 arginine finger; other site 290340003998 Protein of unknown function DUF58; Region: DUF58; pfam01882 290340003999 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290340004000 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290340004001 Double zinc ribbon; Region: DZR; pfam12773 290340004002 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 290340004003 RDD family; Region: RDD; pfam06271 290340004004 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290340004005 phosphopeptide binding site; other site 290340004006 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290340004007 Protein phosphatase 2C; Region: PP2C; pfam00481 290340004008 active site 290340004009 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290340004010 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340004011 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340004012 active site 290340004013 ATP binding site [chemical binding]; other site 290340004014 substrate binding site [chemical binding]; other site 290340004015 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290340004016 substrate binding site [chemical binding]; other site 290340004017 activation loop (A-loop); other site 290340004018 activation loop (A-loop); other site 290340004019 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340004020 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290340004021 phosphopeptide binding site; other site 290340004022 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 290340004023 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 290340004024 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290340004025 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290340004026 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290340004027 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290340004028 nucleotide binding pocket [chemical binding]; other site 290340004029 K-X-D-G motif; other site 290340004030 catalytic site [active] 290340004031 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290340004032 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290340004033 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290340004034 Dimer interface [polypeptide binding]; other site 290340004035 BRCT sequence motif; other site 290340004036 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290340004037 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290340004038 active site 290340004039 dimerization interface [polypeptide binding]; other site 290340004040 Predicted ATPase [General function prediction only]; Region: COG4637 290340004041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340004042 Walker A/P-loop; other site 290340004043 ATP binding site [chemical binding]; other site 290340004044 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340004045 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340004046 active site 290340004047 catalytic tetrad [active] 290340004048 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340004049 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340004050 active site 290340004051 non-prolyl cis peptide bond; other site 290340004052 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340004053 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290340004054 Walker A/P-loop; other site 290340004055 ATP binding site [chemical binding]; other site 290340004056 Q-loop/lid; other site 290340004057 ABC transporter signature motif; other site 290340004058 Walker B; other site 290340004059 D-loop; other site 290340004060 H-loop/switch region; other site 290340004061 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340004063 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340004064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 290340004065 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 290340004066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340004067 Coenzyme A binding pocket [chemical binding]; other site 290340004068 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 290340004069 homotrimer interaction site [polypeptide binding]; other site 290340004070 putative active site [active] 290340004071 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340004072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004073 active site 290340004074 dimerization interface [polypeptide binding]; other site 290340004075 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 290340004076 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290340004077 PAS domain; Region: PAS; smart00091 290340004078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004079 ATP binding site [chemical binding]; other site 290340004080 Mg2+ binding site [ion binding]; other site 290340004081 G-X-G motif; other site 290340004082 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 290340004083 Citrate transporter; Region: CitMHS; pfam03600 290340004084 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 290340004085 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 290340004086 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340004087 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 290340004088 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 290340004089 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 290340004090 GatB domain; Region: GatB_Yqey; smart00845 290340004091 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290340004092 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 290340004093 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340004094 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290340004095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340004096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340004097 dimer interface [polypeptide binding]; other site 290340004098 conserved gate region; other site 290340004099 putative PBP binding loops; other site 290340004100 ABC-ATPase subunit interface; other site 290340004101 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340004102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340004103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340004104 DNA binding site [nucleotide binding] 290340004105 domain linker motif; other site 290340004106 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340004107 dimerization interface [polypeptide binding]; other site 290340004108 ligand binding site [chemical binding]; other site 290340004109 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340004110 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340004111 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340004112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340004113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340004114 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340004115 putative dimerization interface [polypeptide binding]; other site 290340004116 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290340004117 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290340004118 NAD(P) binding site [chemical binding]; other site 290340004119 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290340004120 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290340004121 substrate-cofactor binding pocket; other site 290340004122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004123 catalytic residue [active] 290340004124 Transposase; Region: HTH_Tnp_1; pfam01527 290340004125 HTH-like domain; Region: HTH_21; pfam13276 290340004126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340004127 Integrase core domain; Region: rve; pfam00665 290340004128 Integrase core domain; Region: rve_3; pfam13683 290340004129 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340004130 imidazolonepropionase; Provisional; Region: PRK14085 290340004131 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340004132 active site 290340004133 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 290340004134 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340004135 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 290340004136 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 290340004137 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 290340004138 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290340004139 dimer interface [polypeptide binding]; other site 290340004140 active site 290340004141 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340004142 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340004143 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340004144 nucleotide binding site [chemical binding]; other site 290340004145 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290340004146 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290340004147 putative substrate binding site [chemical binding]; other site 290340004148 putative ATP binding site [chemical binding]; other site 290340004149 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290340004150 intersubunit interface [polypeptide binding]; other site 290340004151 active site 290340004152 zinc binding site [ion binding]; other site 290340004153 Na+ binding site [ion binding]; other site 290340004154 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340004155 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290340004156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340004157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340004158 catalytic core [active] 290340004159 CAAX protease self-immunity; Region: Abi; pfam02517 290340004160 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 290340004161 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 290340004162 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340004163 homodimer interface [polypeptide binding]; other site 290340004164 substrate-cofactor binding pocket; other site 290340004165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004166 catalytic residue [active] 290340004167 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 290340004168 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 290340004169 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290340004170 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340004171 active site 290340004172 catalytic triad [active] 290340004173 oxyanion hole [active] 290340004174 Predicted esterase [General function prediction only]; Region: COG0400 290340004175 putative hydrolase; Provisional; Region: PRK11460 290340004176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340004177 RNA binding surface [nucleotide binding]; other site 290340004178 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290340004179 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290340004180 glycyl-tRNA synthetase; Provisional; Region: PRK04173 290340004181 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290340004182 motif 1; other site 290340004183 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 290340004184 active site 290340004185 motif 2; other site 290340004186 motif 3; other site 290340004187 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 290340004188 anticodon binding site; other site 290340004189 YibE/F-like protein; Region: YibE_F; pfam07907 290340004190 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 290340004191 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290340004192 FMN binding site [chemical binding]; other site 290340004193 active site 290340004194 catalytic residues [active] 290340004195 substrate binding site [chemical binding]; other site 290340004196 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 290340004197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290340004198 Zn2+ binding site [ion binding]; other site 290340004199 Mg2+ binding site [ion binding]; other site 290340004200 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 290340004201 DNA primase; Validated; Region: dnaG; PRK05667 290340004202 CHC2 zinc finger; Region: zf-CHC2; pfam01807 290340004203 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340004204 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340004205 active site 290340004206 metal binding site [ion binding]; metal-binding site 290340004207 interdomain interaction site; other site 290340004208 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290340004209 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 290340004210 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 290340004211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004212 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 290340004213 putative substrate translocation pore; other site 290340004214 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290340004215 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 290340004216 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 290340004217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340004218 putative ADP-binding pocket [chemical binding]; other site 290340004219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340004220 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340004221 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290340004222 rRNA interaction site [nucleotide binding]; other site 290340004223 S8 interaction site; other site 290340004224 putative laminin-1 binding site; other site 290340004225 elongation factor Ts; Provisional; Region: tsf; PRK09377 290340004226 UBA/TS-N domain; Region: UBA; pfam00627 290340004227 Elongation factor TS; Region: EF_TS; pfam00889 290340004228 Elongation factor TS; Region: EF_TS; pfam00889 290340004229 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290340004230 putative nucleotide binding site [chemical binding]; other site 290340004231 uridine monophosphate binding site [chemical binding]; other site 290340004232 homohexameric interface [polypeptide binding]; other site 290340004233 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290340004234 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 290340004235 hinge region; other site 290340004236 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 290340004237 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 290340004238 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 290340004239 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004240 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004241 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290340004242 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290340004243 Na binding site [ion binding]; other site 290340004244 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 290340004245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004246 active site 290340004247 phosphorylation site [posttranslational modification] 290340004248 intermolecular recognition site; other site 290340004249 dimerization interface [polypeptide binding]; other site 290340004250 LytTr DNA-binding domain; Region: LytTR; smart00850 290340004251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340004252 Histidine kinase; Region: His_kinase; pfam06580 290340004253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004254 ATP binding site [chemical binding]; other site 290340004255 Mg2+ binding site [ion binding]; other site 290340004256 G-X-G motif; other site 290340004257 Protein of unknown function, DUF485; Region: DUF485; pfam04341 290340004258 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290340004259 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290340004260 Na binding site [ion binding]; other site 290340004261 hypothetical protein; Provisional; Region: PRK07945 290340004262 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 290340004263 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 290340004264 active site 290340004265 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290340004266 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340004267 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340004268 putative DNA binding site [nucleotide binding]; other site 290340004269 putative Zn2+ binding site [ion binding]; other site 290340004270 AsnC family; Region: AsnC_trans_reg; pfam01037 290340004271 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340004272 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340004273 tetramer interface [polypeptide binding]; other site 290340004274 TPP-binding site [chemical binding]; other site 290340004275 heterodimer interface [polypeptide binding]; other site 290340004276 phosphorylation loop region [posttranslational modification] 290340004277 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340004278 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340004279 alpha subunit interface [polypeptide binding]; other site 290340004280 TPP binding site [chemical binding]; other site 290340004281 heterodimer interface [polypeptide binding]; other site 290340004282 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340004283 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 290340004284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340004285 E3 interaction surface; other site 290340004286 lipoyl attachment site [posttranslational modification]; other site 290340004287 e3 binding domain; Region: E3_binding; pfam02817 290340004288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290340004289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340004290 extended (e) SDRs; Region: SDR_e; cd08946 290340004291 NAD(P) binding site [chemical binding]; other site 290340004292 active site 290340004293 substrate binding site [chemical binding]; other site 290340004294 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340004295 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340004296 active site 290340004297 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 290340004298 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290340004299 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290340004300 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290340004301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340004302 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340004303 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340004304 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340004305 carboxyltransferase (CT) interaction site; other site 290340004306 biotinylation site [posttranslational modification]; other site 290340004307 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340004308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340004309 active site 290340004310 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 290340004311 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290340004312 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 290340004313 putative active site [active] 290340004314 putative catalytic site [active] 290340004315 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290340004316 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340004317 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340004318 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340004319 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340004320 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340004321 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340004322 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340004323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340004324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340004325 dimer interface [polypeptide binding]; other site 290340004326 conserved gate region; other site 290340004327 putative PBP binding loops; other site 290340004328 ABC-ATPase subunit interface; other site 290340004329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340004330 dimer interface [polypeptide binding]; other site 290340004331 conserved gate region; other site 290340004332 putative PBP binding loops; other site 290340004333 ABC-ATPase subunit interface; other site 290340004334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340004335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340004336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340004337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340004338 DNA binding site [nucleotide binding] 290340004339 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 290340004340 putative dimerization interface [polypeptide binding]; other site 290340004341 putative ligand binding site [chemical binding]; other site 290340004342 Lipase maturation factor; Region: LMF1; pfam06762 290340004343 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290340004344 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290340004345 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290340004346 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290340004347 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 290340004348 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290340004349 active site 290340004350 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290340004351 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290340004352 putative substrate binding region [chemical binding]; other site 290340004353 YCII-related domain; Region: YCII; cl00999 290340004354 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 290340004355 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290340004356 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290340004357 Predicted acetyltransferase [General function prediction only]; Region: COG3393 290340004358 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 290340004359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340004360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340004361 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290340004362 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290340004363 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340004364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290340004365 Walker A/P-loop; other site 290340004366 ATP binding site [chemical binding]; other site 290340004367 Q-loop/lid; other site 290340004368 ABC transporter signature motif; other site 290340004369 Walker B; other site 290340004370 D-loop; other site 290340004371 H-loop/switch region; other site 290340004372 prolyl-tRNA synthetase; Provisional; Region: PRK09194 290340004373 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 290340004374 dimer interface [polypeptide binding]; other site 290340004375 motif 1; other site 290340004376 active site 290340004377 motif 2; other site 290340004378 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 290340004379 putative deacylase active site [active] 290340004380 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290340004381 active site 290340004382 motif 3; other site 290340004383 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 290340004384 anticodon binding site; other site 290340004385 hypothetical protein; Provisional; Region: PRK10621 290340004386 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340004387 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 290340004388 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 290340004389 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290340004390 Sm and related proteins; Region: Sm_like; cl00259 290340004391 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 290340004392 putative oligomer interface [polypeptide binding]; other site 290340004393 putative RNA binding site [nucleotide binding]; other site 290340004394 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 290340004395 NusA N-terminal domain; Region: NusA_N; pfam08529 290340004396 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290340004397 RNA binding site [nucleotide binding]; other site 290340004398 homodimer interface [polypeptide binding]; other site 290340004399 NusA-like KH domain; Region: KH_5; pfam13184 290340004400 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290340004401 G-X-X-G motif; other site 290340004402 Protein of unknown function (DUF448); Region: DUF448; pfam04296 290340004403 putative RNA binding cleft [nucleotide binding]; other site 290340004404 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290340004405 translation initiation factor IF-2; Region: IF-2; TIGR00487 290340004406 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290340004407 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290340004408 G1 box; other site 290340004409 putative GEF interaction site [polypeptide binding]; other site 290340004410 GTP/Mg2+ binding site [chemical binding]; other site 290340004411 Switch I region; other site 290340004412 G2 box; other site 290340004413 G3 box; other site 290340004414 Switch II region; other site 290340004415 G4 box; other site 290340004416 G5 box; other site 290340004417 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290340004418 Translation-initiation factor 2; Region: IF-2; pfam11987 290340004419 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290340004420 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 290340004421 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340004422 nucleoside/Zn binding site; other site 290340004423 dimer interface [polypeptide binding]; other site 290340004424 catalytic motif [active] 290340004425 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290340004426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340004427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004428 homodimer interface [polypeptide binding]; other site 290340004429 catalytic residue [active] 290340004430 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 290340004431 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 290340004432 RNA binding site [nucleotide binding]; other site 290340004433 active site 290340004434 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290340004435 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290340004436 active site 290340004437 Riboflavin kinase; Region: Flavokinase; smart00904 290340004438 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290340004439 16S/18S rRNA binding site [nucleotide binding]; other site 290340004440 S13e-L30e interaction site [polypeptide binding]; other site 290340004441 25S rRNA binding site [nucleotide binding]; other site 290340004442 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 290340004443 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 290340004444 oligomer interface [polypeptide binding]; other site 290340004445 RNA binding site [nucleotide binding]; other site 290340004446 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290340004447 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290340004448 RNase E interface [polypeptide binding]; other site 290340004449 trimer interface [polypeptide binding]; other site 290340004450 active site 290340004451 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290340004452 putative nucleic acid binding region [nucleotide binding]; other site 290340004453 G-X-X-G motif; other site 290340004454 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290340004455 RNA binding site [nucleotide binding]; other site 290340004456 domain interface; other site 290340004457 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290340004458 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290340004459 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290340004460 Ubiquitin-like proteins; Region: UBQ; cl00155 290340004461 charged pocket; other site 290340004462 hydrophobic patch; other site 290340004463 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290340004464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004465 FeS/SAM binding site; other site 290340004466 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290340004467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340004468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004469 active site 290340004470 phosphorylation site [posttranslational modification] 290340004471 intermolecular recognition site; other site 290340004472 dimerization interface [polypeptide binding]; other site 290340004473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340004474 DNA binding site [nucleotide binding] 290340004475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340004476 dimer interface [polypeptide binding]; other site 290340004477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340004478 phosphorylation site [posttranslational modification] 290340004479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004480 ATP binding site [chemical binding]; other site 290340004481 Mg2+ binding site [ion binding]; other site 290340004482 G-X-G motif; other site 290340004483 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 290340004484 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340004485 Moco binding site; other site 290340004486 metal coordination site [ion binding]; other site 290340004487 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290340004488 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290340004489 dimer interface [polypeptide binding]; other site 290340004490 putative functional site; other site 290340004491 putative MPT binding site; other site 290340004492 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290340004493 trimer interface [polypeptide binding]; other site 290340004494 dimer interface [polypeptide binding]; other site 290340004495 putative active site [active] 290340004496 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 290340004497 MoaE homodimer interface [polypeptide binding]; other site 290340004498 MoaD interaction [polypeptide binding]; other site 290340004499 active site residues [active] 290340004500 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290340004501 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 290340004502 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290340004503 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290340004504 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340004505 dimer interface [polypeptide binding]; other site 290340004506 active site 290340004507 catalytic residue [active] 290340004508 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 290340004509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340004510 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290340004511 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290340004512 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 290340004513 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290340004514 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 290340004515 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290340004516 Competence-damaged protein; Region: CinA; pfam02464 290340004517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340004518 non-specific DNA binding site [nucleotide binding]; other site 290340004519 salt bridge; other site 290340004520 sequence-specific DNA binding site [nucleotide binding]; other site 290340004521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340004522 MarR family; Region: MarR; pfam01047 290340004523 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 290340004524 recombinase A; Provisional; Region: recA; PRK09354 290340004525 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290340004526 hexamer interface [polypeptide binding]; other site 290340004527 Walker A motif; other site 290340004528 ATP binding site [chemical binding]; other site 290340004529 Walker B motif; other site 290340004530 recombination regulator RecX; Reviewed; Region: recX; PRK00117 290340004531 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 290340004532 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290340004533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004534 FeS/SAM binding site; other site 290340004535 TRAM domain; Region: TRAM; cl01282 290340004536 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 290340004537 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290340004538 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290340004539 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290340004540 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290340004541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340004542 S-adenosylmethionine binding site [chemical binding]; other site 290340004543 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 290340004544 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290340004545 HflX GTPase family; Region: HflX; cd01878 290340004546 G1 box; other site 290340004547 GTP/Mg2+ binding site [chemical binding]; other site 290340004548 Switch I region; other site 290340004549 G2 box; other site 290340004550 G3 box; other site 290340004551 Switch II region; other site 290340004552 G4 box; other site 290340004553 G5 box; other site 290340004554 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 290340004555 DEAD/DEAH box helicase; Region: DEAD; pfam00270 290340004556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340004557 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290340004558 LexA repressor; Validated; Region: PRK00215 290340004559 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 290340004560 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290340004561 Catalytic site [active] 290340004562 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340004563 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 290340004564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004566 homodimer interface [polypeptide binding]; other site 290340004567 catalytic residue [active] 290340004568 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290340004569 4-fold oligomerization interface [polypeptide binding]; other site 290340004570 putative active site pocket [active] 290340004571 metal binding residues [ion binding]; metal-binding site 290340004572 3-fold/trimer interface [polypeptide binding]; other site 290340004573 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 290340004574 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290340004575 putative active site [active] 290340004576 oxyanion strand; other site 290340004577 catalytic triad [active] 290340004578 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290340004579 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 290340004580 catalytic residues [active] 290340004581 translation initiation factor IF-3; Region: infC; TIGR00168 290340004582 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290340004583 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290340004584 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 290340004585 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290340004586 23S rRNA binding site [nucleotide binding]; other site 290340004587 L21 binding site [polypeptide binding]; other site 290340004588 L13 binding site [polypeptide binding]; other site 290340004589 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 290340004590 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290340004591 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290340004592 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290340004593 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290340004594 Cation efflux family; Region: Cation_efflux; pfam01545 290340004595 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340004596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340004597 putative substrate translocation pore; other site 290340004598 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290340004599 active site 290340004600 8-oxo-dGMP binding site [chemical binding]; other site 290340004601 nudix motif; other site 290340004602 metal binding site [ion binding]; metal-binding site 290340004603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340004604 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290340004605 FeS/SAM binding site; other site 290340004606 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 290340004607 putative substrate binding pocket [chemical binding]; other site 290340004608 AC domain interface; other site 290340004609 catalytic triad [active] 290340004610 AB domain interface; other site 290340004611 interchain disulfide; other site 290340004612 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 290340004613 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290340004614 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290340004615 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290340004616 dimer interface [polypeptide binding]; other site 290340004617 motif 1; other site 290340004618 active site 290340004619 motif 2; other site 290340004620 motif 3; other site 290340004621 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290340004622 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290340004623 putative tRNA-binding site [nucleotide binding]; other site 290340004624 B3/4 domain; Region: B3_4; pfam03483 290340004625 tRNA synthetase B5 domain; Region: B5; pfam03484 290340004626 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290340004627 dimer interface [polypeptide binding]; other site 290340004628 motif 1; other site 290340004629 motif 3; other site 290340004630 motif 2; other site 290340004631 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 290340004632 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 290340004633 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290340004634 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 290340004635 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 290340004636 Zn binding site [ion binding]; other site 290340004637 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340004638 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290340004639 acyl-activating enzyme (AAE) consensus motif; other site 290340004640 AMP binding site [chemical binding]; other site 290340004641 active site 290340004642 CoA binding site [chemical binding]; other site 290340004643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290340004644 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 290340004645 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004646 putative trimer interface [polypeptide binding]; other site 290340004647 putative CoA binding site [chemical binding]; other site 290340004648 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004649 putative CoA binding site [chemical binding]; other site 290340004650 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340004651 putative trimer interface [polypeptide binding]; other site 290340004652 putative CoA binding site [chemical binding]; other site 290340004653 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290340004654 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 290340004655 NADP binding site [chemical binding]; other site 290340004656 dimer interface [polypeptide binding]; other site 290340004657 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290340004658 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340004659 putative di-iron ligands [ion binding]; other site 290340004660 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290340004661 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290340004662 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 290340004663 heterotetramer interface [polypeptide binding]; other site 290340004664 active site pocket [active] 290340004665 cleavage site 290340004666 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 290340004667 feedback inhibition sensing region; other site 290340004668 homohexameric interface [polypeptide binding]; other site 290340004669 nucleotide binding site [chemical binding]; other site 290340004670 N-acetyl-L-glutamate binding site [chemical binding]; other site 290340004671 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 290340004672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340004673 inhibitor-cofactor binding pocket; inhibition site 290340004674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340004675 catalytic residue [active] 290340004676 ornithine carbamoyltransferase; Provisional; Region: PRK00779 290340004677 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290340004678 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290340004679 arginine repressor; Provisional; Region: PRK03341 290340004680 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290340004681 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290340004682 argininosuccinate synthase; Provisional; Region: PRK13820 290340004683 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290340004684 ANP binding site [chemical binding]; other site 290340004685 Substrate Binding Site II [chemical binding]; other site 290340004686 Substrate Binding Site I [chemical binding]; other site 290340004687 argininosuccinate lyase; Provisional; Region: PRK00855 290340004688 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290340004689 active sites [active] 290340004690 tetramer interface [polypeptide binding]; other site 290340004691 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290340004692 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290340004693 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 290340004694 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 290340004695 AlkA N-terminal domain; Region: AlkA_N; pfam06029 290340004696 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 290340004697 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340004698 minor groove reading motif; other site 290340004699 helix-hairpin-helix signature motif; other site 290340004700 substrate binding pocket [chemical binding]; other site 290340004701 active site 290340004702 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 290340004703 active site 290340004704 DNA binding site [nucleotide binding] 290340004705 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 290340004706 Part of AAA domain; Region: AAA_19; pfam13245 290340004707 Family description; Region: UvrD_C_2; pfam13538 290340004708 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290340004709 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290340004710 active site 290340004711 HIGH motif; other site 290340004712 dimer interface [polypeptide binding]; other site 290340004713 KMSKS motif; other site 290340004714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 290340004715 RNA binding surface [nucleotide binding]; other site 290340004716 transcription termination factor Rho; Provisional; Region: PRK12678 290340004717 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 290340004718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340004719 active site 290340004720 motif I; other site 290340004721 motif II; other site 290340004722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340004723 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 290340004724 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340004725 RNA binding surface [nucleotide binding]; other site 290340004726 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 290340004727 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 290340004728 ATP-NAD kinase; Region: NAD_kinase; pfam01513 290340004729 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 290340004730 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290340004731 Walker A/P-loop; other site 290340004732 ATP binding site [chemical binding]; other site 290340004733 Q-loop/lid; other site 290340004734 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290340004735 ABC transporter signature motif; other site 290340004736 Walker B; other site 290340004737 D-loop; other site 290340004738 H-loop/switch region; other site 290340004739 CTP synthetase; Validated; Region: pyrG; PRK05380 290340004740 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290340004741 Catalytic site [active] 290340004742 active site 290340004743 UTP binding site [chemical binding]; other site 290340004744 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290340004745 active site 290340004746 putative oxyanion hole; other site 290340004747 catalytic triad [active] 290340004748 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290340004749 dimer interface [polypeptide binding]; other site 290340004750 ADP-ribose binding site [chemical binding]; other site 290340004751 active site 290340004752 nudix motif; other site 290340004753 metal binding site [ion binding]; metal-binding site 290340004754 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 290340004755 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290340004756 active site 290340004757 Int/Topo IB signature motif; other site 290340004758 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340004759 nudix motif; other site 290340004760 citrate synthase; Provisional; Region: PRK14033 290340004761 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290340004762 oxalacetate binding site [chemical binding]; other site 290340004763 citrylCoA binding site [chemical binding]; other site 290340004764 coenzyme A binding site [chemical binding]; other site 290340004765 catalytic triad [active] 290340004766 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340004767 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340004768 tetramer interface [polypeptide binding]; other site 290340004769 active site 290340004770 Mg2+/Mn2+ binding site [ion binding]; other site 290340004771 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 290340004772 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340004773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340004774 DNA-binding site [nucleotide binding]; DNA binding site 290340004775 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290340004776 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290340004777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340004778 S-adenosylmethionine binding site [chemical binding]; other site 290340004779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340004780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340004781 DNA binding residues [nucleotide binding] 290340004782 dimerization interface [polypeptide binding]; other site 290340004783 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290340004784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340004785 active site 290340004786 phosphorylation site [posttranslational modification] 290340004787 intermolecular recognition site; other site 290340004788 dimerization interface [polypeptide binding]; other site 290340004789 FaeA-like protein; Region: FaeA; pfam04703 290340004790 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290340004791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340004792 ATP binding site [chemical binding]; other site 290340004793 G-X-G motif; other site 290340004794 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290340004795 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290340004796 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340004797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004798 P-loop; other site 290340004799 Magnesium ion binding site [ion binding]; other site 290340004800 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004801 Magnesium ion binding site [ion binding]; other site 290340004802 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 290340004803 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 290340004804 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 290340004805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340004806 RNA binding surface [nucleotide binding]; other site 290340004807 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 290340004808 active site 290340004809 prephenate dehydrogenase; Validated; Region: PRK06545 290340004810 prephenate dehydrogenase; Validated; Region: PRK08507 290340004811 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290340004812 cytidylate kinase; Provisional; Region: cmk; PRK00023 290340004813 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290340004814 CMP-binding site; other site 290340004815 The sites determining sugar specificity; other site 290340004816 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290340004817 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340004818 putative acyl-acceptor binding pocket; other site 290340004819 GTP-binding protein Der; Reviewed; Region: PRK03003 290340004820 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290340004821 G1 box; other site 290340004822 GTP/Mg2+ binding site [chemical binding]; other site 290340004823 Switch I region; other site 290340004824 G2 box; other site 290340004825 Switch II region; other site 290340004826 G3 box; other site 290340004827 G4 box; other site 290340004828 G5 box; other site 290340004829 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290340004830 G1 box; other site 290340004831 GTP/Mg2+ binding site [chemical binding]; other site 290340004832 Switch I region; other site 290340004833 G2 box; other site 290340004834 G3 box; other site 290340004835 Switch II region; other site 290340004836 G4 box; other site 290340004837 G5 box; other site 290340004838 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340004839 MarR family; Region: MarR_2; cl17246 290340004840 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340004841 lipoyl attachment site [posttranslational modification]; other site 290340004842 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340004843 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290340004844 phosphopeptide binding site; other site 290340004845 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 290340004846 DNA binding residues [nucleotide binding] 290340004847 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340004848 Bifunctional nuclease; Region: DNase-RNase; pfam02577 290340004849 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 290340004850 DNA binding residues [nucleotide binding] 290340004851 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340004852 putative dimer interface [polypeptide binding]; other site 290340004853 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340004854 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340004855 Magnesium ion binding site [ion binding]; other site 290340004856 pyruvate carboxylase; Reviewed; Region: PRK12999 290340004857 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340004858 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340004859 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340004860 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290340004861 active site 290340004862 catalytic residues [active] 290340004863 metal binding site [ion binding]; metal-binding site 290340004864 homodimer binding site [polypeptide binding]; other site 290340004865 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340004866 carboxyltransferase (CT) interaction site; other site 290340004867 biotinylation site [posttranslational modification]; other site 290340004868 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290340004869 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290340004870 acyl-activating enzyme (AAE) consensus motif; other site 290340004871 putative AMP binding site [chemical binding]; other site 290340004872 putative active site [active] 290340004873 putative CoA binding site [chemical binding]; other site 290340004874 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340004875 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340004876 nucleotide binding site [chemical binding]; other site 290340004877 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 290340004878 Esterase/lipase [General function prediction only]; Region: COG1647 290340004879 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290340004880 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340004881 putative acyl-acceptor binding pocket; other site 290340004882 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 290340004883 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340004884 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340004885 active site 290340004886 ATP binding site [chemical binding]; other site 290340004887 substrate binding site [chemical binding]; other site 290340004888 activation loop (A-loop); other site 290340004889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 290340004890 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004891 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004892 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004893 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340004894 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340004895 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340004896 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340004897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340004898 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 290340004899 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290340004900 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290340004901 catalytic residue [active] 290340004902 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290340004903 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340004904 substrate binding pocket [chemical binding]; other site 290340004905 chain length determination region; other site 290340004906 substrate-Mg2+ binding site; other site 290340004907 catalytic residues [active] 290340004908 aspartate-rich region 1; other site 290340004909 active site lid residues [active] 290340004910 aspartate-rich region 2; other site 290340004911 DNA polymerase IV; Validated; Region: PRK02406 290340004912 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290340004913 active site 290340004914 DNA binding site [nucleotide binding] 290340004915 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340004916 cell division protein MraZ; Reviewed; Region: PRK00326 290340004917 MraZ protein; Region: MraZ; pfam02381 290340004918 MraZ protein; Region: MraZ; pfam02381 290340004919 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 290340004920 MraW methylase family; Region: Methyltransf_5; cl17771 290340004921 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290340004922 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290340004923 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290340004924 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290340004925 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004928 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 290340004929 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004930 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004931 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004932 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290340004933 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290340004934 Mg++ binding site [ion binding]; other site 290340004935 putative catalytic motif [active] 290340004936 putative substrate binding site [chemical binding]; other site 290340004937 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 290340004938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004940 cell division protein FtsW; Region: ftsW; TIGR02614 290340004941 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290340004942 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290340004943 active site 290340004944 homodimer interface [polypeptide binding]; other site 290340004945 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290340004946 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290340004947 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340004948 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340004949 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290340004950 Cell division protein FtsQ; Region: FtsQ; pfam03799 290340004951 cell division protein FtsZ; Validated; Region: PRK09330 290340004952 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290340004953 nucleotide binding site [chemical binding]; other site 290340004954 SulA interaction site; other site 290340004955 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 290340004956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 290340004957 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340004958 catalytic residue [active] 290340004959 Protein of unknown function (DUF552); Region: DUF552; pfam04472 290340004960 DivIVA protein; Region: DivIVA; pfam05103 290340004961 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340004962 lipoprotein signal peptidase; Provisional; Region: PRK14772 290340004963 lipoprotein signal peptidase; Provisional; Region: PRK14787 290340004964 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290340004965 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290340004966 active site 290340004967 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290340004968 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 290340004969 active site 290340004970 PHP Thumb interface [polypeptide binding]; other site 290340004971 metal binding site [ion binding]; metal-binding site 290340004972 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290340004973 generic binding surface II; other site 290340004974 generic binding surface I; other site 290340004975 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290340004976 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290340004977 histidinol dehydrogenase; Region: hisD; TIGR00069 290340004978 NAD binding site [chemical binding]; other site 290340004979 dimerization interface [polypeptide binding]; other site 290340004980 product binding site; other site 290340004981 substrate binding site [chemical binding]; other site 290340004982 zinc binding site [ion binding]; other site 290340004983 catalytic residues [active] 290340004984 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 290340004985 ATP cone domain; Region: ATP-cone; pfam03477 290340004986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340004987 short chain dehydrogenase; Provisional; Region: PRK06123 290340004988 NAD(P) binding site [chemical binding]; other site 290340004989 active site 290340004990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340004991 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340004992 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340004993 active site 290340004994 Sporulation related domain; Region: SPOR; cl10051 290340004995 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290340004996 oligomerization interface [polypeptide binding]; other site 290340004997 active site 290340004998 metal binding site [ion binding]; metal-binding site 290340004999 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340005000 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340005001 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340005002 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 290340005003 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290340005004 metal binding triad; other site 290340005005 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290340005006 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290340005007 metal binding triad; other site 290340005008 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290340005009 arylsulfatase; Provisional; Region: PRK13759 290340005010 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290340005011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340005012 HTH-like domain; Region: HTH_21; pfam13276 290340005013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340005014 Integrase core domain; Region: rve; pfam00665 290340005015 Integrase core domain; Region: rve_3; pfam13683 290340005016 Transposase; Region: HTH_Tnp_1; pfam01527 290340005017 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340005018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340005019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340005020 active site 290340005021 DNA binding site [nucleotide binding] 290340005022 Int/Topo IB signature motif; other site 290340005023 glutamine synthetase, type I; Region: GlnA; TIGR00653 290340005024 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340005025 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340005026 RDD family; Region: RDD; cl00746 290340005027 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 290340005028 lipoyl synthase; Provisional; Region: PRK05481 290340005029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340005030 FeS/SAM binding site; other site 290340005031 lipoate-protein ligase B; Provisional; Region: PRK14345 290340005032 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340005033 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340005034 active site 290340005035 ATP binding site [chemical binding]; other site 290340005036 substrate binding site [chemical binding]; other site 290340005037 activation loop (A-loop); other site 290340005038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005039 TIGR01777 family protein; Region: yfcH 290340005040 NAD(P) binding site [chemical binding]; other site 290340005041 active site 290340005042 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 290340005043 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 290340005044 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290340005045 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290340005046 protein binding site [polypeptide binding]; other site 290340005047 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 290340005048 Domain interface; other site 290340005049 Peptide binding site; other site 290340005050 Active site tetrad [active] 290340005051 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 290340005052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340005053 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340005054 active site 290340005055 metal binding site [ion binding]; metal-binding site 290340005056 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340005057 E3 interaction surface; other site 290340005058 lipoyl attachment site [posttranslational modification]; other site 290340005059 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340005060 E3 interaction surface; other site 290340005061 lipoyl attachment site [posttranslational modification]; other site 290340005062 e3 binding domain; Region: E3_binding; pfam02817 290340005063 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340005064 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290340005065 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290340005066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340005067 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340005068 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290340005069 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290340005070 interface (dimer of trimers) [polypeptide binding]; other site 290340005071 Substrate-binding/catalytic site; other site 290340005072 Zn-binding sites [ion binding]; other site 290340005073 PAC2 family; Region: PAC2; pfam09754 290340005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340005076 putative substrate translocation pore; other site 290340005077 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340005078 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340005079 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 290340005080 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290340005081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340005082 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290340005083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340005084 DNA binding residues [nucleotide binding] 290340005085 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 290340005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340005087 ATP binding site [chemical binding]; other site 290340005088 Mg2+ binding site [ion binding]; other site 290340005089 G-X-G motif; other site 290340005090 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290340005091 anchoring element; other site 290340005092 dimer interface [polypeptide binding]; other site 290340005093 ATP binding site [chemical binding]; other site 290340005094 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290340005095 active site 290340005096 metal binding site [ion binding]; metal-binding site 290340005097 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290340005098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005101 Peptidase family M48; Region: Peptidase_M48; cl12018 290340005102 Penicillinase repressor; Region: Pencillinase_R; cl17580 290340005103 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290340005104 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290340005105 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290340005106 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290340005107 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290340005108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340005109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340005110 Coenzyme A binding pocket [chemical binding]; other site 290340005111 DinB superfamily; Region: DinB_2; pfam12867 290340005112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340005113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340005114 active site 290340005115 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 290340005116 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290340005117 CAP-like domain; other site 290340005118 active site 290340005119 primary dimer interface [polypeptide binding]; other site 290340005120 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290340005121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 290340005122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340005123 Coenzyme A binding pocket [chemical binding]; other site 290340005124 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 290340005125 CoA binding domain; Region: CoA_binding_2; pfam13380 290340005126 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 290340005127 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 290340005128 Uncharacterized conserved protein [Function unknown]; Region: COG3379 290340005129 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290340005130 PglZ domain; Region: PglZ; pfam08665 290340005131 thymidine kinase; Provisional; Region: PRK04296 290340005132 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 290340005133 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340005134 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 290340005135 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290340005136 trimer interface [polypeptide binding]; other site 290340005137 active site 290340005138 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 290340005139 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 290340005140 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340005141 TrkA-N domain; Region: TrkA_N; pfam02254 290340005142 TrkA-C domain; Region: TrkA_C; pfam02080 290340005143 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340005144 TrkA-N domain; Region: TrkA_N; pfam02254 290340005145 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340005146 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 290340005147 TRAM domain; Region: TRAM; pfam01938 290340005148 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 290340005149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340005150 S-adenosylmethionine binding site [chemical binding]; other site 290340005151 aconitate hydratase; Validated; Region: PRK09277 290340005152 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290340005153 substrate binding site [chemical binding]; other site 290340005154 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290340005155 ligand binding site [chemical binding]; other site 290340005156 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290340005157 substrate binding site [chemical binding]; other site 290340005158 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290340005159 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 290340005160 TPP-binding site [chemical binding]; other site 290340005161 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340005162 PYR/PP interface [polypeptide binding]; other site 290340005163 dimer interface [polypeptide binding]; other site 290340005164 TPP binding site [chemical binding]; other site 290340005165 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005166 Protein of unknown function (DUF402); Region: DUF402; pfam04167 290340005167 Protein of unknown function (DUF402); Region: DUF402; cl00979 290340005168 hypothetical protein; Provisional; Region: PRK07758 290340005169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340005170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340005171 active site 290340005172 catalytic tetrad [active] 290340005173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340005174 substrate binding site [chemical binding]; other site 290340005175 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 290340005176 oxyanion hole (OAH) forming residues; other site 290340005177 trimer interface [polypeptide binding]; other site 290340005178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 290340005179 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290340005180 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340005181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340005182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340005183 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290340005184 dimer interface [polypeptide binding]; other site 290340005185 active site 290340005186 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 290340005187 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 290340005188 catalytic site [active] 290340005189 putative active site [active] 290340005190 putative substrate binding site [chemical binding]; other site 290340005191 Helicase and RNase D C-terminal; Region: HRDC; smart00341 290340005192 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 290340005193 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 290340005194 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290340005195 tetramer interface [polypeptide binding]; other site 290340005196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005197 catalytic residue [active] 290340005198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005199 active site 290340005200 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 290340005201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340005202 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340005203 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 290340005204 putative deacylase active site [active] 290340005205 Fe-S metabolism associated domain; Region: SufE; cl00951 290340005206 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290340005207 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340005208 active site residue [active] 290340005209 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340005210 active site residue [active] 290340005211 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 290340005212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290340005213 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 290340005214 benzoate transporter; Region: benE; TIGR00843 290340005215 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 290340005216 amino acid transporter; Region: 2A0306; TIGR00909 290340005217 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290340005218 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290340005219 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340005220 active site 290340005221 catalytic residues [active] 290340005222 metal binding site [ion binding]; metal-binding site 290340005223 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290340005224 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290340005225 putative active site [active] 290340005226 substrate binding site [chemical binding]; other site 290340005227 putative cosubstrate binding site; other site 290340005228 catalytic site [active] 290340005229 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290340005230 substrate binding site [chemical binding]; other site 290340005231 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290340005232 putative RNA binding site [nucleotide binding]; other site 290340005233 16S rRNA methyltransferase B; Provisional; Region: PRK14902 290340005234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340005235 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 290340005236 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290340005237 substrate binding site [chemical binding]; other site 290340005238 hexamer interface [polypeptide binding]; other site 290340005239 metal binding site [ion binding]; metal-binding site 290340005240 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 290340005241 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290340005242 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 290340005243 catalytic motif [active] 290340005244 Zn binding site [ion binding]; other site 290340005245 RibD C-terminal domain; Region: RibD_C; cl17279 290340005246 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 290340005247 Lumazine binding domain; Region: Lum_binding; pfam00677 290340005248 Lumazine binding domain; Region: Lum_binding; pfam00677 290340005249 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290340005250 homopentamer interface [polypeptide binding]; other site 290340005251 active site 290340005252 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 290340005253 metal binding site [ion binding]; metal-binding site 290340005254 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290340005255 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 290340005256 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 290340005257 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290340005258 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290340005259 substrate binding site [chemical binding]; other site 290340005260 glutamase interaction surface [polypeptide binding]; other site 290340005261 TIGR03085 family protein; Region: TIGR03085 290340005262 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 290340005263 anthranilate synthase component I; Provisional; Region: PRK13571 290340005264 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290340005265 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290340005266 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290340005267 active site 290340005268 ribulose/triose binding site [chemical binding]; other site 290340005269 phosphate binding site [ion binding]; other site 290340005270 substrate (anthranilate) binding pocket [chemical binding]; other site 290340005271 product (indole) binding pocket [chemical binding]; other site 290340005272 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 290340005273 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290340005274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005275 catalytic residue [active] 290340005276 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 290340005277 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290340005278 substrate binding site [chemical binding]; other site 290340005279 active site 290340005280 catalytic residues [active] 290340005281 heterodimer interface [polypeptide binding]; other site 290340005282 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290340005283 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290340005284 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290340005285 active site 290340005286 dimer interface [polypeptide binding]; other site 290340005287 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290340005288 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290340005289 active site 290340005290 FMN binding site [chemical binding]; other site 290340005291 substrate binding site [chemical binding]; other site 290340005292 3Fe-4S cluster binding site [ion binding]; other site 290340005293 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290340005294 domain interface; other site 290340005295 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 290340005296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340005297 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 290340005298 pyruvate kinase; Provisional; Region: PRK06247 290340005299 domain interfaces; other site 290340005300 active site 290340005301 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 290340005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340005303 active site 290340005304 phosphorylation site [posttranslational modification] 290340005305 intermolecular recognition site; other site 290340005306 dimerization interface [polypeptide binding]; other site 290340005307 ANTAR domain; Region: ANTAR; pfam03861 290340005308 putative phosphoketolase; Provisional; Region: PRK05261 290340005309 XFP N-terminal domain; Region: XFP_N; pfam09364 290340005310 XFP C-terminal domain; Region: XFP_C; pfam09363 290340005311 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 290340005312 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340005313 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290340005314 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290340005315 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340005316 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290340005317 thioredoxin 2; Provisional; Region: PRK10996 290340005318 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340005319 catalytic residues [active] 290340005320 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 290340005321 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 290340005322 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005323 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290340005324 methionine synthase; Provisional; Region: PRK01207 290340005325 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290340005326 substrate binding site [chemical binding]; other site 290340005327 THF binding site; other site 290340005328 zinc-binding site [ion binding]; other site 290340005329 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 290340005330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340005331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340005332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340005333 dimerization interface [polypeptide binding]; other site 290340005334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340005335 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340005336 active site 290340005337 catalytic tetrad [active] 290340005338 hydroperoxidase II; Provisional; Region: katE; PRK11249 290340005339 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 290340005340 heme binding pocket [chemical binding]; other site 290340005341 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 290340005342 domain interactions; other site 290340005343 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290340005344 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340005345 NAD binding site [chemical binding]; other site 290340005346 catalytic Zn binding site [ion binding]; other site 290340005347 structural Zn binding site [ion binding]; other site 290340005348 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 290340005349 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 290340005350 NAD binding site [chemical binding]; other site 290340005351 catalytic Zn binding site [ion binding]; other site 290340005352 structural Zn binding site [ion binding]; other site 290340005353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340005354 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290340005355 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340005356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290340005357 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290340005358 ligand binding site [chemical binding]; other site 290340005359 flexible hinge region; other site 290340005360 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290340005361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340005362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340005363 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 290340005364 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290340005365 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 290340005366 nucleotide binding site [chemical binding]; other site 290340005367 NEF interaction site [polypeptide binding]; other site 290340005368 SBD interface [polypeptide binding]; other site 290340005369 GrpE; Region: GrpE; pfam01025 290340005370 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290340005371 dimer interface [polypeptide binding]; other site 290340005372 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290340005373 chaperone protein DnaJ; Provisional; Region: PRK14299 290340005374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340005375 HSP70 interaction site [polypeptide binding]; other site 290340005376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290340005377 substrate binding site [polypeptide binding]; other site 290340005378 dimer interface [polypeptide binding]; other site 290340005379 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 290340005380 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 290340005381 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290340005382 Clp amino terminal domain; Region: Clp_N; pfam02861 290340005383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005384 Walker A motif; other site 290340005385 ATP binding site [chemical binding]; other site 290340005386 Walker B motif; other site 290340005387 arginine finger; other site 290340005388 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 290340005389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005390 Walker A motif; other site 290340005391 ATP binding site [chemical binding]; other site 290340005392 Walker B motif; other site 290340005393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290340005394 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290340005395 thioredoxin 2; Provisional; Region: PRK10996 290340005396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340005397 catalytic residues [active] 290340005398 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340005399 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340005400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290340005401 nucleotide binding site [chemical binding]; other site 290340005402 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005404 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005405 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005406 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005407 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005408 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340005409 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340005410 TM-ABC transporter signature motif; other site 290340005411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290340005412 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290340005413 ligand binding site [chemical binding]; other site 290340005414 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005415 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005416 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340005417 DNA interaction; other site 290340005418 Metal-binding active site; metal-binding site 290340005419 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340005420 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340005421 Walker A/P-loop; other site 290340005422 ATP binding site [chemical binding]; other site 290340005423 Q-loop/lid; other site 290340005424 ABC transporter signature motif; other site 290340005425 Walker B; other site 290340005426 D-loop; other site 290340005427 H-loop/switch region; other site 290340005428 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340005429 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340005431 Metal-binding active site; metal-binding site 290340005432 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290340005433 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290340005434 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290340005435 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290340005436 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290340005437 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 290340005438 Fic/DOC family; Region: Fic; cl00960 290340005439 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340005440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340005441 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 290340005442 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290340005443 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340005444 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340005445 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290340005446 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 290340005447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340005448 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340005449 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340005450 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290340005451 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290340005452 NAD(P) binding site [chemical binding]; other site 290340005453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 290340005454 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 290340005455 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 290340005456 dimer interface [polypeptide binding]; other site 290340005457 active site 290340005458 catalytic residue [active] 290340005459 metal binding site [ion binding]; metal-binding site 290340005460 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 290340005461 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005463 DNA-binding site [nucleotide binding]; DNA binding site 290340005464 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290340005465 Domain of unknown function DUF11; Region: DUF11; cl17728 290340005466 Cna protein B-type domain; Region: Cna_B; pfam05738 290340005467 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 290340005468 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 290340005469 active site 290340005470 catalytic site [active] 290340005471 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340005472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340005473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340005474 DNA binding residues [nucleotide binding] 290340005475 Putative zinc-finger; Region: zf-HC2; pfam13490 290340005476 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340005477 TPP-binding site [chemical binding]; other site 290340005478 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340005479 PYR/PP interface [polypeptide binding]; other site 290340005480 dimer interface [polypeptide binding]; other site 290340005481 TPP binding site [chemical binding]; other site 290340005482 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 290340005483 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340005484 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290340005485 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 290340005486 tetramer interface [polypeptide binding]; other site 290340005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005488 catalytic residue [active] 290340005489 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290340005490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340005491 Walker A/P-loop; other site 290340005492 ATP binding site [chemical binding]; other site 290340005493 Q-loop/lid; other site 290340005494 ABC transporter signature motif; other site 290340005495 Walker B; other site 290340005496 D-loop; other site 290340005497 H-loop/switch region; other site 290340005498 TOBE domain; Region: TOBE_2; pfam08402 290340005499 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290340005500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005501 ABC-ATPase subunit interface; other site 290340005502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005503 dimer interface [polypeptide binding]; other site 290340005504 conserved gate region; other site 290340005505 putative PBP binding loops; other site 290340005506 ABC-ATPase subunit interface; other site 290340005507 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 290340005508 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005510 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340005511 putative substrate translocation pore; other site 290340005512 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 290340005513 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 290340005514 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 290340005515 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340005516 catalytic loop [active] 290340005517 iron binding site [ion binding]; other site 290340005518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290340005519 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 290340005520 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 290340005521 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290340005522 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290340005523 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 290340005524 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290340005525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340005526 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 290340005527 NAD(P) binding site [chemical binding]; other site 290340005528 catalytic residues [active] 290340005529 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340005530 homotrimer interaction site [polypeptide binding]; other site 290340005531 putative active site [active] 290340005532 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340005533 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 290340005534 FMN-binding pocket [chemical binding]; other site 290340005535 flavin binding motif; other site 290340005536 phosphate binding motif [ion binding]; other site 290340005537 beta-alpha-beta structure motif; other site 290340005538 NAD binding pocket [chemical binding]; other site 290340005539 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340005540 catalytic loop [active] 290340005541 iron binding site [ion binding]; other site 290340005542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340005543 active site 290340005544 metal binding site [ion binding]; metal-binding site 290340005545 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 290340005546 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 290340005547 putative active site [active] 290340005548 Mn binding site [ion binding]; other site 290340005549 putative oligomer interface [polypeptide binding]; other site 290340005550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340005551 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290340005552 catalytic site [active] 290340005553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340005554 classical (c) SDRs; Region: SDR_c; cd05233 290340005555 NAD(P) binding site [chemical binding]; other site 290340005556 active site 290340005557 short chain dehydrogenase; Provisional; Region: PRK07062 290340005558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005559 NAD(P) binding site [chemical binding]; other site 290340005560 active site 290340005561 hypothetical protein; Provisional; Region: PRK07064 290340005562 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340005563 PYR/PP interface [polypeptide binding]; other site 290340005564 dimer interface [polypeptide binding]; other site 290340005565 TPP binding site [chemical binding]; other site 290340005566 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340005567 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290340005568 TPP-binding site [chemical binding]; other site 290340005569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340005570 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290340005571 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340005572 iron-sulfur cluster [ion binding]; other site 290340005573 [2Fe-2S] cluster binding site [ion binding]; other site 290340005574 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340005575 hydrophobic ligand binding site; other site 290340005576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340005577 MarR family; Region: MarR; pfam01047 290340005578 MarR family; Region: MarR_2; cl17246 290340005579 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290340005580 Domain of unknown function DUF108; Region: DUF108; pfam01958 290340005581 hypothetical protein; Provisional; Region: PRK06062 290340005582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340005583 inhibitor-cofactor binding pocket; inhibition site 290340005584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005585 catalytic residue [active] 290340005586 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340005587 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340005588 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340005589 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290340005590 tetrameric interface [polypeptide binding]; other site 290340005591 NAD binding site [chemical binding]; other site 290340005592 catalytic residues [active] 290340005593 mycothione reductase; Region: mycothione_red; TIGR03452 290340005594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340005595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340005596 conserved hypothetical protein; Region: TIGR03843 290340005597 conserved hypothetical protein; Region: TIGR03847 290340005598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340005599 catalytic core [active] 290340005600 stage V sporulation protein K; Region: spore_V_K; TIGR02881 290340005601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340005602 Walker A motif; other site 290340005603 ATP binding site [chemical binding]; other site 290340005604 Walker B motif; other site 290340005605 arginine finger; other site 290340005606 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 290340005607 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290340005608 dimerization interface [polypeptide binding]; other site 290340005609 ligand binding site [chemical binding]; other site 290340005610 NADP binding site [chemical binding]; other site 290340005611 catalytic site [active] 290340005612 aspartate aminotransferase; Provisional; Region: PRK05764 290340005613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340005614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340005615 homodimer interface [polypeptide binding]; other site 290340005616 catalytic residue [active] 290340005617 Protein of unknown function (DUF808); Region: DUF808; cl01002 290340005618 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290340005619 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290340005620 potential catalytic triad [active] 290340005621 conserved cys residue [active] 290340005622 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340005623 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340005624 DNA binding site [nucleotide binding] 290340005625 domain linker motif; other site 290340005626 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340005627 putative dimerization interface [polypeptide binding]; other site 290340005628 putative ligand binding site [chemical binding]; other site 290340005629 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290340005630 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 290340005631 substrate binding site [chemical binding]; other site 290340005632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340005633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005634 dimer interface [polypeptide binding]; other site 290340005635 conserved gate region; other site 290340005636 putative PBP binding loops; other site 290340005637 ABC-ATPase subunit interface; other site 290340005638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005640 dimer interface [polypeptide binding]; other site 290340005641 conserved gate region; other site 290340005642 putative PBP binding loops; other site 290340005643 ABC-ATPase subunit interface; other site 290340005644 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290340005645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340005646 Walker A/P-loop; other site 290340005647 ATP binding site [chemical binding]; other site 290340005648 Q-loop/lid; other site 290340005649 ABC transporter signature motif; other site 290340005650 Walker B; other site 290340005651 D-loop; other site 290340005652 H-loop/switch region; other site 290340005653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340005654 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 290340005655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340005656 Walker A/P-loop; other site 290340005657 ATP binding site [chemical binding]; other site 290340005658 Q-loop/lid; other site 290340005659 ABC transporter signature motif; other site 290340005660 Walker B; other site 290340005661 D-loop; other site 290340005662 H-loop/switch region; other site 290340005663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290340005664 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290340005665 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340005666 substrate binding [chemical binding]; other site 290340005667 active site 290340005668 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340005669 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 290340005670 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340005671 substrate binding [chemical binding]; other site 290340005672 active site 290340005673 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290340005674 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340005675 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290340005676 putative substrate binding site [chemical binding]; other site 290340005677 putative ATP binding site [chemical binding]; other site 290340005678 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340005679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340005680 Walker A/P-loop; other site 290340005681 ATP binding site [chemical binding]; other site 290340005682 Q-loop/lid; other site 290340005683 ABC transporter signature motif; other site 290340005684 Walker B; other site 290340005685 D-loop; other site 290340005686 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290340005687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340005688 ABC-ATPase subunit interface; other site 290340005689 dimer interface [polypeptide binding]; other site 290340005690 putative PBP binding regions; other site 290340005691 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 290340005692 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340005693 intersubunit interface [polypeptide binding]; other site 290340005694 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 290340005695 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 290340005696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 290340005697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340005698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340005699 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340005700 putative dimerization interface [polypeptide binding]; other site 290340005701 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 290340005702 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340005703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340005704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005705 dimer interface [polypeptide binding]; other site 290340005706 conserved gate region; other site 290340005707 putative PBP binding loops; other site 290340005708 ABC-ATPase subunit interface; other site 290340005709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340005710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340005711 dimer interface [polypeptide binding]; other site 290340005712 conserved gate region; other site 290340005713 putative PBP binding loops; other site 290340005714 ABC-ATPase subunit interface; other site 290340005715 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340005716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340005717 Walker A/P-loop; other site 290340005718 ATP binding site [chemical binding]; other site 290340005719 Q-loop/lid; other site 290340005720 ABC transporter signature motif; other site 290340005721 Walker B; other site 290340005722 D-loop; other site 290340005723 H-loop/switch region; other site 290340005724 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340005725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340005726 Walker A/P-loop; other site 290340005727 ATP binding site [chemical binding]; other site 290340005728 Q-loop/lid; other site 290340005729 ABC transporter signature motif; other site 290340005730 Walker B; other site 290340005731 D-loop; other site 290340005732 H-loop/switch region; other site 290340005733 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290340005734 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340005735 putative di-iron ligands [ion binding]; other site 290340005736 GAF domain; Region: GAF; pfam01590 290340005737 GAF domain; Region: GAF_2; pfam13185 290340005738 ANTAR domain; Region: ANTAR; pfam03861 290340005739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290340005740 GAF domain; Region: GAF_2; pfam13185 290340005741 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290340005742 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 290340005743 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290340005744 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340005745 substrate binding site [chemical binding]; other site 290340005746 ATP binding site [chemical binding]; other site 290340005747 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 290340005748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340005749 PYR/PP interface [polypeptide binding]; other site 290340005750 dimer interface [polypeptide binding]; other site 290340005751 TPP binding site [chemical binding]; other site 290340005752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340005753 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 290340005754 TPP-binding site; other site 290340005755 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290340005756 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290340005757 tetrameric interface [polypeptide binding]; other site 290340005758 NAD binding site [chemical binding]; other site 290340005759 catalytic residues [active] 290340005760 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005761 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005762 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005763 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005764 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005765 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340005766 DNA interaction; other site 290340005767 Metal-binding active site; metal-binding site 290340005768 putative oxidoreductase; Provisional; Region: PRK11579 290340005769 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005770 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340005771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005772 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005773 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340005775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340005776 DNA binding site [nucleotide binding] 290340005777 domain linker motif; other site 290340005778 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340005779 ligand binding site [chemical binding]; other site 290340005780 dimerization interface [polypeptide binding]; other site 290340005781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290340005782 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 290340005783 putative ligand binding site [chemical binding]; other site 290340005784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290340005785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290340005786 TM-ABC transporter signature motif; other site 290340005787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340005788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340005789 Walker A/P-loop; other site 290340005790 ATP binding site [chemical binding]; other site 290340005791 Q-loop/lid; other site 290340005792 ABC transporter signature motif; other site 290340005793 Walker B; other site 290340005794 D-loop; other site 290340005795 H-loop/switch region; other site 290340005796 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005798 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005799 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005800 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005804 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340005805 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340005806 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340005807 KduI/IolB family; Region: KduI; pfam04962 290340005808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005810 DNA-binding site [nucleotide binding]; DNA binding site 290340005811 UTRA domain; Region: UTRA; pfam07702 290340005812 ChaB; Region: ChaB; pfam06150 290340005813 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 290340005814 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340005815 active site 290340005816 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340005817 peptide synthase; Provisional; Region: PRK09274 290340005818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340005819 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340005820 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 290340005821 acyl-activating enzyme (AAE) consensus motif; other site 290340005822 acyl-activating enzyme (AAE) consensus motif; other site 290340005823 putative AMP binding site [chemical binding]; other site 290340005824 putative active site [active] 290340005825 putative CoA binding site [chemical binding]; other site 290340005826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340005827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340005828 NAD(P) binding site [chemical binding]; other site 290340005829 active site 290340005830 amino acid transporter; Region: 2A0306; TIGR00909 290340005831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340005832 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 290340005833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290340005834 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290340005835 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 290340005836 RibD C-terminal domain; Region: RibD_C; cl17279 290340005837 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 290340005838 nucleotide binding site [chemical binding]; other site 290340005839 pyruvate dehydrogenase; Provisional; Region: PRK06546 290340005840 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290340005841 PYR/PP interface [polypeptide binding]; other site 290340005842 dimer interface [polypeptide binding]; other site 290340005843 tetramer interface [polypeptide binding]; other site 290340005844 TPP binding site [chemical binding]; other site 290340005845 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340005846 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290340005847 TPP-binding site [chemical binding]; other site 290340005848 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 290340005849 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290340005850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340005851 ABC transporter signature motif; other site 290340005852 Walker B; other site 290340005853 D-loop; other site 290340005854 H-loop/switch region; other site 290340005855 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290340005856 SnoaL-like domain; Region: SnoaL_3; pfam13474 290340005857 SnoaL-like domain; Region: SnoaL_2; pfam12680 290340005858 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340005859 homotrimer interaction site [polypeptide binding]; other site 290340005860 putative active site [active] 290340005861 hypothetical protein; Provisional; Region: PRK09256 290340005862 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340005863 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340005864 Walker A/P-loop; other site 290340005865 ATP binding site [chemical binding]; other site 290340005866 Q-loop/lid; other site 290340005867 ABC transporter signature motif; other site 290340005868 Walker B; other site 290340005869 D-loop; other site 290340005870 H-loop/switch region; other site 290340005871 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290340005872 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340005873 siderophore binding site; other site 290340005874 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340005875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340005876 putative PBP binding regions; other site 290340005877 ABC-ATPase subunit interface; other site 290340005878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340005879 dimer interface [polypeptide binding]; other site 290340005880 putative PBP binding regions; other site 290340005881 ABC-ATPase subunit interface; other site 290340005882 putative ATPase RIL; Provisional; Region: PRK13409 290340005883 RibD C-terminal domain; Region: RibD_C; cl17279 290340005884 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 290340005885 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290340005886 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 290340005887 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 290340005888 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290340005889 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340005890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340005891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340005892 putative substrate translocation pore; other site 290340005893 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 290340005894 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340005895 metal ion-dependent adhesion site (MIDAS); other site 290340005896 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340005897 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 290340005898 Walker A motif; other site 290340005899 ATP binding site [chemical binding]; other site 290340005900 Walker B motif; other site 290340005901 arginine finger; other site 290340005902 SWIM zinc finger; Region: SWIM; pfam04434 290340005903 phenol 2-monooxygenase; Provisional; Region: PRK08294 290340005904 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 290340005905 dimer interface [polypeptide binding]; other site 290340005906 5'-3' exonuclease; Region: 53EXOc; smart00475 290340005907 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290340005908 active site 290340005909 metal binding site 1 [ion binding]; metal-binding site 290340005910 putative 5' ssDNA interaction site; other site 290340005911 metal binding site 3; metal-binding site 290340005912 metal binding site 2 [ion binding]; metal-binding site 290340005913 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290340005914 putative DNA binding site [nucleotide binding]; other site 290340005915 putative metal binding site [ion binding]; other site 290340005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 290340005917 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 290340005918 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340005919 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340005920 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340005921 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340005922 active site 290340005923 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340005924 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290340005925 putative NAD(P) binding site [chemical binding]; other site 290340005926 putative substrate binding site [chemical binding]; other site 290340005927 catalytic Zn binding site [ion binding]; other site 290340005928 structural Zn binding site [ion binding]; other site 290340005929 dimer interface [polypeptide binding]; other site 290340005930 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 290340005931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340005932 putative Mg++ binding site [ion binding]; other site 290340005933 nucleotide binding region [chemical binding]; other site 290340005934 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 290340005935 ATP-binding site [chemical binding]; other site 290340005936 Helicase associated domain (HA2); Region: HA2; pfam04408 290340005937 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 290340005938 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340005939 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340005940 active site 290340005941 Amino acid permease; Region: AA_permease_2; pfam13520 290340005942 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 290340005943 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 290340005944 elongation factor G; Reviewed; Region: PRK12740 290340005945 G1 box; other site 290340005946 putative GEF interaction site [polypeptide binding]; other site 290340005947 GTP/Mg2+ binding site [chemical binding]; other site 290340005948 Switch I region; other site 290340005949 G2 box; other site 290340005950 G3 box; other site 290340005951 Switch II region; other site 290340005952 G4 box; other site 290340005953 G5 box; other site 290340005954 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290340005955 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290340005956 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290340005957 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 290340005958 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 290340005959 nucleotide binding site [chemical binding]; other site 290340005960 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340005961 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340005962 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290340005963 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 290340005964 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340005966 Walker A/P-loop; other site 290340005967 ATP binding site [chemical binding]; other site 290340005968 Q-loop/lid; other site 290340005969 ABC transporter signature motif; other site 290340005970 Walker B; other site 290340005971 D-loop; other site 290340005972 H-loop/switch region; other site 290340005973 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 290340005974 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 290340005975 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 290340005976 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340005977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340005978 DNA-binding site [nucleotide binding]; DNA binding site 290340005979 UTRA domain; Region: UTRA; pfam07702 290340005980 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 290340005981 PaaX-like protein; Region: PaaX; pfam07848 290340005982 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 290340005983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340005984 kynureninase; Region: kynureninase; TIGR01814 290340005985 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340005986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340005987 catalytic residue [active] 290340005988 catalytic residue [active] 290340005989 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 290340005990 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290340005991 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340005992 RibD C-terminal domain; Region: RibD_C; cl17279 290340005993 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290340005994 CoenzymeA binding site [chemical binding]; other site 290340005995 subunit interaction site [polypeptide binding]; other site 290340005996 PHB binding site; other site 290340005997 DNA polymerase I; Provisional; Region: PRK05755 290340005998 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290340005999 active site 290340006000 putative 5' ssDNA interaction site; other site 290340006001 metal binding site 3; metal-binding site 290340006002 metal binding site 1 [ion binding]; metal-binding site 290340006003 metal binding site 2 [ion binding]; metal-binding site 290340006004 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290340006005 putative DNA binding site [nucleotide binding]; other site 290340006006 putative metal binding site [ion binding]; other site 290340006007 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 290340006008 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290340006009 active site 290340006010 DNA binding site [nucleotide binding] 290340006011 catalytic site [active] 290340006012 hypothetical protein; Provisional; Region: PRK01346 290340006013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 290340006014 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 290340006015 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290340006016 NodB motif; other site 290340006017 putative active site [active] 290340006018 putative catalytic site [active] 290340006019 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 290340006020 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290340006021 RNA binding site [nucleotide binding]; other site 290340006022 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290340006023 RNA binding site [nucleotide binding]; other site 290340006024 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290340006025 RNA binding site [nucleotide binding]; other site 290340006026 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290340006027 RNA binding site [nucleotide binding]; other site 290340006028 domain interface; other site 290340006029 Uncharacterized conserved protein [Function unknown]; Region: COG1739 290340006030 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 290340006031 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 290340006032 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 290340006033 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290340006034 CoA-binding site [chemical binding]; other site 290340006035 ATP-binding [chemical binding]; other site 290340006036 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 290340006037 excinuclease ABC subunit B; Provisional; Region: PRK05298 290340006038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340006039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340006040 nucleotide binding region [chemical binding]; other site 290340006041 ATP-binding site [chemical binding]; other site 290340006042 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290340006043 UvrB/uvrC motif; Region: UVR; pfam02151 290340006044 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290340006045 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290340006046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340006047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340006048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340006049 Coenzyme A binding pocket [chemical binding]; other site 290340006050 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340006051 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340006052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340006053 ATP binding site [chemical binding]; other site 290340006054 putative Mg++ binding site [ion binding]; other site 290340006055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340006056 nucleotide binding region [chemical binding]; other site 290340006057 ATP-binding site [chemical binding]; other site 290340006058 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 290340006059 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 290340006060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006061 S-adenosylmethionine binding site [chemical binding]; other site 290340006062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340006063 DNA-binding site [nucleotide binding]; DNA binding site 290340006064 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290340006065 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290340006066 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290340006067 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290340006068 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290340006069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340006070 active site 290340006071 motif I; other site 290340006072 motif II; other site 290340006073 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340006074 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290340006075 putative acyl-acceptor binding pocket; other site 290340006076 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 290340006077 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290340006078 GIY-YIG motif/motif A; other site 290340006079 active site 290340006080 catalytic site [active] 290340006081 putative DNA binding site [nucleotide binding]; other site 290340006082 metal binding site [ion binding]; metal-binding site 290340006083 UvrB/uvrC motif; Region: UVR; pfam02151 290340006084 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290340006085 Helix-hairpin-helix motif; Region: HHH; pfam00633 290340006086 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 290340006087 shikimate kinase; Reviewed; Region: aroK; PRK00131 290340006088 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 290340006089 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 290340006090 putative substrate binding pocket [chemical binding]; other site 290340006091 dimer interface [polypeptide binding]; other site 290340006092 phosphate binding site [ion binding]; other site 290340006093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 290340006094 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 290340006095 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 290340006096 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290340006097 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290340006098 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 290340006099 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 290340006100 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290340006101 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290340006102 Phosphoglycerate kinase; Region: PGK; pfam00162 290340006103 substrate binding site [chemical binding]; other site 290340006104 hinge regions; other site 290340006105 ADP binding site [chemical binding]; other site 290340006106 catalytic site [active] 290340006107 triosephosphate isomerase; Provisional; Region: PRK14567 290340006108 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290340006109 substrate binding site [chemical binding]; other site 290340006110 dimer interface [polypeptide binding]; other site 290340006111 catalytic triad [active] 290340006112 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 290340006113 putative active site [active] 290340006114 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290340006115 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 290340006116 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 290340006117 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290340006118 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290340006119 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290340006120 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 290340006121 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290340006122 active site 290340006123 dimer interface [polypeptide binding]; other site 290340006124 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290340006125 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 290340006126 putative active site [active] 290340006127 transaldolase; Provisional; Region: PRK03903 290340006128 catalytic residue [active] 290340006129 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 290340006130 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340006131 TPP-binding site [chemical binding]; other site 290340006132 dimer interface [polypeptide binding]; other site 290340006133 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340006134 PYR/PP interface [polypeptide binding]; other site 290340006135 dimer interface [polypeptide binding]; other site 290340006136 TPP binding site [chemical binding]; other site 290340006137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340006138 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 290340006139 UbiA prenyltransferase family; Region: UbiA; pfam01040 290340006140 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 290340006141 putative active site [active] 290340006142 putative metal-binding site [ion binding]; other site 290340006143 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 290340006144 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 290340006145 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290340006146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340006147 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290340006148 Walker A/P-loop; other site 290340006149 ATP binding site [chemical binding]; other site 290340006150 Q-loop/lid; other site 290340006151 ABC transporter signature motif; other site 290340006152 Walker B; other site 290340006153 D-loop; other site 290340006154 H-loop/switch region; other site 290340006155 Predicted transcriptional regulator [Transcription]; Region: COG2345 290340006156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340006157 putative DNA binding site [nucleotide binding]; other site 290340006158 putative Zn2+ binding site [ion binding]; other site 290340006159 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 290340006160 FeS assembly protein SufB; Region: sufB; TIGR01980 290340006161 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 290340006162 FeS assembly protein SufD; Region: sufD; TIGR01981 290340006163 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 290340006164 [2Fe-2S] cluster binding site [ion binding]; other site 290340006165 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 290340006166 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 290340006167 Walker A/P-loop; other site 290340006168 ATP binding site [chemical binding]; other site 290340006169 Q-loop/lid; other site 290340006170 ABC transporter signature motif; other site 290340006171 Walker B; other site 290340006172 D-loop; other site 290340006173 H-loop/switch region; other site 290340006174 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 290340006175 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 290340006176 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 290340006177 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 290340006178 acyl-activating enzyme (AAE) consensus motif; other site 290340006179 AMP binding site [chemical binding]; other site 290340006180 active site 290340006181 CoA binding site [chemical binding]; other site 290340006182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340006183 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290340006184 dimer interface [polypeptide binding]; other site 290340006185 active site 290340006186 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 290340006187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006188 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340006189 Walker A/P-loop; other site 290340006190 ATP binding site [chemical binding]; other site 290340006191 Q-loop/lid; other site 290340006192 ABC transporter signature motif; other site 290340006193 Walker B; other site 290340006194 D-loop; other site 290340006195 H-loop/switch region; other site 290340006196 BioY family; Region: BioY; pfam02632 290340006197 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340006198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006199 Walker A/P-loop; other site 290340006200 ATP binding site [chemical binding]; other site 290340006201 Q-loop/lid; other site 290340006202 ABC transporter signature motif; other site 290340006203 Walker B; other site 290340006204 D-loop; other site 290340006205 H-loop/switch region; other site 290340006206 ABC transporter; Region: ABC_tran_2; pfam12848 290340006207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340006208 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 290340006209 putative deacylase active site [active] 290340006210 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340006211 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 290340006212 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290340006213 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290340006214 NAD(P) binding site [chemical binding]; other site 290340006215 homotetramer interface [polypeptide binding]; other site 290340006216 homodimer interface [polypeptide binding]; other site 290340006217 active site 290340006218 short chain dehydrogenase; Provisional; Region: PRK07806 290340006219 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 290340006220 NAD(P) binding site [chemical binding]; other site 290340006221 active site 290340006222 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290340006223 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290340006224 Walker A/P-loop; other site 290340006225 ATP binding site [chemical binding]; other site 290340006226 Q-loop/lid; other site 290340006227 ABC transporter signature motif; other site 290340006228 Walker B; other site 290340006229 D-loop; other site 290340006230 H-loop/switch region; other site 290340006231 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290340006232 phosphoserine phosphatase SerB; Region: serB; TIGR00338 290340006233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340006234 motif II; other site 290340006235 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340006236 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290340006237 Walker A/P-loop; other site 290340006238 ATP binding site [chemical binding]; other site 290340006239 Q-loop/lid; other site 290340006240 ABC transporter signature motif; other site 290340006241 Walker B; other site 290340006242 D-loop; other site 290340006243 H-loop/switch region; other site 290340006244 hypothetical protein; Provisional; Region: PRK10621 290340006245 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340006246 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290340006247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290340006248 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 290340006249 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 290340006250 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290340006251 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290340006252 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290340006253 Zn binding site [ion binding]; other site 290340006254 Predicted membrane protein [Function unknown]; Region: COG2855 290340006255 Uncharacterized conserved protein [Function unknown]; Region: COG2308 290340006256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 290340006257 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 290340006258 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290340006259 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 290340006260 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290340006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006262 NAD(P) binding site [chemical binding]; other site 290340006263 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290340006264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006265 active site 290340006266 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 290340006267 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 290340006268 ligand binding site; other site 290340006269 oligomer interface; other site 290340006270 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290340006271 sulfate 1 binding site; other site 290340006272 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 290340006273 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290340006274 acyl-coenzyme A oxidase; Region: PLN02636 290340006275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340006276 active site 290340006277 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 290340006278 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340006279 dimer interface [polypeptide binding]; other site 290340006280 active site 290340006281 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 290340006282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006283 NAD(P) binding site [chemical binding]; other site 290340006284 active site 290340006285 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340006286 active site 2 [active] 290340006287 active site 1 [active] 290340006288 hypothetical protein; Provisional; Region: PRK07906 290340006289 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 290340006290 putative metal binding site [ion binding]; other site 290340006291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340006292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340006293 active site 290340006294 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340006295 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290340006296 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340006297 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340006298 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340006299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006300 NAD(P) binding site [chemical binding]; other site 290340006301 active site 290340006302 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290340006303 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290340006304 inhibitor-cofactor binding pocket; inhibition site 290340006305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340006306 catalytic residue [active] 290340006307 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 290340006308 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 290340006309 putative trimer interface [polypeptide binding]; other site 290340006310 putative CoA binding site [chemical binding]; other site 290340006311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340006312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340006313 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 290340006314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290340006315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340006316 active site 290340006317 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 290340006318 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 290340006319 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290340006320 putative ADP-binding pocket [chemical binding]; other site 290340006321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340006322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340006323 active site 290340006324 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290340006325 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290340006326 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340006327 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290340006328 Probable Catalytic site; other site 290340006329 metal-binding site 290340006330 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 290340006331 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 290340006332 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290340006333 NADP binding site [chemical binding]; other site 290340006334 active site 290340006335 putative substrate binding site [chemical binding]; other site 290340006336 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290340006337 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290340006338 NAD binding site [chemical binding]; other site 290340006339 substrate binding site [chemical binding]; other site 290340006340 homodimer interface [polypeptide binding]; other site 290340006341 active site 290340006342 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290340006343 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290340006344 substrate binding site; other site 290340006345 tetramer interface; other site 290340006346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340006347 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340006348 active site 290340006349 catalytic tetrad [active] 290340006350 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 290340006351 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 290340006352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006353 active site 290340006354 HIGH motif; other site 290340006355 nucleotide binding site [chemical binding]; other site 290340006356 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006357 active site 290340006358 KMSKS motif; other site 290340006359 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290340006360 tRNA binding surface [nucleotide binding]; other site 290340006361 anticodon binding site; other site 290340006362 PAC2 family; Region: PAC2; pfam09754 290340006363 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290340006364 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290340006365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340006366 motif II; other site 290340006367 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 290340006368 active site 290340006369 Peptidase family M50; Region: Peptidase_M50; pfam02163 290340006370 putative substrate binding region [chemical binding]; other site 290340006371 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 290340006372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006373 S-adenosylmethionine binding site [chemical binding]; other site 290340006374 proteasome ATPase; Region: pup_AAA; TIGR03689 290340006375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006376 Walker A motif; other site 290340006377 ATP binding site [chemical binding]; other site 290340006378 Walker B motif; other site 290340006379 arginine finger; other site 290340006380 Pup-ligase protein; Region: Pup_ligase; pfam03136 290340006381 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 290340006382 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290340006383 active site 290340006384 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 290340006385 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290340006386 active site 290340006387 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 290340006388 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290340006389 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290340006390 WYL domain; Region: WYL; pfam13280 290340006391 Predicted transcriptional regulator [Transcription]; Region: COG2378 290340006392 WYL domain; Region: WYL; pfam13280 290340006393 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 290340006394 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290340006395 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 290340006396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340006397 ATP binding site [chemical binding]; other site 290340006398 putative Mg++ binding site [ion binding]; other site 290340006399 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 290340006400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340006401 nucleotide binding region [chemical binding]; other site 290340006402 ATP-binding site [chemical binding]; other site 290340006403 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 290340006404 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340006405 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340006406 active site 290340006407 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290340006408 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 290340006409 Ligand binding site; other site 290340006410 Putative Catalytic site; other site 290340006411 DXD motif; other site 290340006412 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 290340006413 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290340006414 HflK protein; Region: hflK; TIGR01933 290340006415 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 290340006416 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 290340006417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006418 S-adenosylmethionine binding site [chemical binding]; other site 290340006419 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290340006420 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290340006421 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340006422 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340006423 active site 290340006424 catalytic residues [active] 290340006425 metal binding site [ion binding]; metal-binding site 290340006426 SnoaL-like domain; Region: SnoaL_2; pfam12680 290340006427 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290340006428 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290340006429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006430 S-adenosylmethionine binding site [chemical binding]; other site 290340006431 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 290340006432 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 290340006433 malonyl-CoA binding site [chemical binding]; other site 290340006434 dimer interface [polypeptide binding]; other site 290340006435 active site 290340006436 product binding site; other site 290340006437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006438 Walker A/P-loop; other site 290340006439 ATP binding site [chemical binding]; other site 290340006440 Q-loop/lid; other site 290340006441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006442 ABC transporter signature motif; other site 290340006443 Walker B; other site 290340006444 D-loop; other site 290340006445 H-loop/switch region; other site 290340006446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006447 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 290340006448 Walker A/P-loop; other site 290340006449 ATP binding site [chemical binding]; other site 290340006450 Q-loop/lid; other site 290340006451 ABC transporter signature motif; other site 290340006452 Walker B; other site 290340006453 D-loop; other site 290340006454 H-loop/switch region; other site 290340006455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340006456 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290340006457 dimer interface [polypeptide binding]; other site 290340006458 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290340006459 active site 290340006460 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 290340006461 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340006462 AsnC family; Region: AsnC_trans_reg; pfam01037 290340006463 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290340006464 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290340006465 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290340006466 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 290340006467 Subunit I/III interface [polypeptide binding]; other site 290340006468 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 290340006469 Cytochrome c; Region: Cytochrom_C; pfam00034 290340006470 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 290340006471 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290340006472 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290340006473 iron-sulfur cluster [ion binding]; other site 290340006474 [2Fe-2S] cluster binding site [ion binding]; other site 290340006475 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 290340006476 heme bH binding site [chemical binding]; other site 290340006477 intrachain domain interface; other site 290340006478 heme bL binding site [chemical binding]; other site 290340006479 interchain domain interface [polypeptide binding]; other site 290340006480 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 290340006481 Qo binding site; other site 290340006482 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340006483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340006484 DNA-binding site [nucleotide binding]; DNA binding site 290340006485 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290340006486 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 290340006487 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 290340006488 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 290340006489 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 290340006490 D-pathway; other site 290340006491 Putative ubiquinol binding site [chemical binding]; other site 290340006492 Low-spin heme (heme b) binding site [chemical binding]; other site 290340006493 Putative water exit pathway; other site 290340006494 Binuclear center (heme o3/CuB) [ion binding]; other site 290340006495 K-pathway; other site 290340006496 Putative proton exit pathway; other site 290340006497 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 290340006498 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 290340006499 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 290340006500 hypothetical protein; Provisional; Region: PRK07907 290340006501 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 290340006502 active site 290340006503 metal binding site [ion binding]; metal-binding site 290340006504 dimer interface [polypeptide binding]; other site 290340006505 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 290340006506 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 290340006507 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 290340006508 quinone interaction residues [chemical binding]; other site 290340006509 active site 290340006510 catalytic residues [active] 290340006511 FMN binding site [chemical binding]; other site 290340006512 substrate binding site [chemical binding]; other site 290340006513 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290340006514 FAD binding domain; Region: FAD_binding_2; pfam00890 290340006515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290340006516 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340006517 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290340006518 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340006519 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290340006520 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290340006521 catalytic residue [active] 290340006522 putative FPP diphosphate binding site; other site 290340006523 putative FPP binding hydrophobic cleft; other site 290340006524 dimer interface [polypeptide binding]; other site 290340006525 putative IPP diphosphate binding site; other site 290340006526 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290340006527 Recombination protein O N terminal; Region: RecO_N; pfam11967 290340006528 Recombination protein O C terminal; Region: RecO_C; pfam02565 290340006529 2-isopropylmalate synthase; Validated; Region: PRK03739 290340006530 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 290340006531 active site 290340006532 catalytic residues [active] 290340006533 metal binding site [ion binding]; metal-binding site 290340006534 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 290340006535 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 290340006536 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 290340006537 active site 290340006538 Zn binding site [ion binding]; other site 290340006539 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 290340006540 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290340006541 GTPase Era; Reviewed; Region: era; PRK00089 290340006542 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290340006543 G1 box; other site 290340006544 GTP/Mg2+ binding site [chemical binding]; other site 290340006545 Switch I region; other site 290340006546 G2 box; other site 290340006547 Switch II region; other site 290340006548 G3 box; other site 290340006549 G4 box; other site 290340006550 G5 box; other site 290340006551 KH domain; Region: KH_2; pfam07650 290340006552 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340006553 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340006554 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340006555 Transporter associated domain; Region: CorC_HlyC; smart01091 290340006556 metal-binding heat shock protein; Provisional; Region: PRK00016 290340006557 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290340006558 PhoH-like protein; Region: PhoH; pfam02562 290340006559 Sporulation and spore germination; Region: Germane; pfam10646 290340006560 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 290340006561 RNA methyltransferase, RsmE family; Region: TIGR00046 290340006562 chaperone protein DnaJ; Provisional; Region: PRK14278 290340006563 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340006564 HSP70 interaction site [polypeptide binding]; other site 290340006565 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290340006566 Zn binding sites [ion binding]; other site 290340006567 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290340006568 dimer interface [polypeptide binding]; other site 290340006569 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 290340006570 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 290340006571 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 290340006572 Tic20-like protein; Region: Tic20; pfam09685 290340006573 coproporphyrinogen III oxidase; Validated; Region: PRK05628 290340006574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340006575 FeS/SAM binding site; other site 290340006576 GTP-binding protein LepA; Provisional; Region: PRK05433 290340006577 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290340006578 G1 box; other site 290340006579 putative GEF interaction site [polypeptide binding]; other site 290340006580 GTP/Mg2+ binding site [chemical binding]; other site 290340006581 Switch I region; other site 290340006582 G2 box; other site 290340006583 G3 box; other site 290340006584 Switch II region; other site 290340006585 G4 box; other site 290340006586 G5 box; other site 290340006587 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 290340006588 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290340006589 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290340006590 PemK-like protein; Region: PemK; pfam02452 290340006591 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 290340006592 hypothetical protein; Reviewed; Region: PRK07914 290340006593 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290340006594 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 290340006595 Competence protein; Region: Competence; pfam03772 290340006596 SLBB domain; Region: SLBB; pfam10531 290340006597 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290340006598 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340006599 EDD domain protein, DegV family; Region: DegV; TIGR00762 290340006600 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 290340006601 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290340006602 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290340006603 HIGH motif; other site 290340006604 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290340006605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340006606 active site 290340006607 KMSKS motif; other site 290340006608 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290340006609 tRNA binding surface [nucleotide binding]; other site 290340006610 glycerol kinase; Provisional; Region: glpK; PRK00047 290340006611 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 290340006612 N- and C-terminal domain interface [polypeptide binding]; other site 290340006613 active site 290340006614 MgATP binding site [chemical binding]; other site 290340006615 catalytic site [active] 290340006616 metal binding site [ion binding]; metal-binding site 290340006617 putative homotetramer interface [polypeptide binding]; other site 290340006618 glycerol binding site [chemical binding]; other site 290340006619 homodimer interface [polypeptide binding]; other site 290340006620 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 290340006621 amphipathic channel; other site 290340006622 Asn-Pro-Ala signature motifs; other site 290340006623 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 290340006624 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 290340006625 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 290340006626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340006627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340006628 active site 290340006629 catalytic tetrad [active] 290340006630 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 290340006631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340006632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340006633 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290340006634 benzoate transport; Region: 2A0115; TIGR00895 290340006635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340006636 putative substrate translocation pore; other site 290340006637 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340006638 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 290340006639 FMN-binding pocket [chemical binding]; other site 290340006640 flavin binding motif; other site 290340006641 phosphate binding motif [ion binding]; other site 290340006642 beta-alpha-beta structure motif; other site 290340006643 NAD binding pocket [chemical binding]; other site 290340006644 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340006645 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290340006646 catalytic loop [active] 290340006647 iron binding site [ion binding]; other site 290340006648 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340006649 Transcriptional regulator PadR-like family; Region: PadR; cl17335 290340006650 primosome assembly protein PriA; Provisional; Region: PRK14873 290340006651 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290340006652 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290340006653 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290340006654 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290340006655 Flavoprotein; Region: Flavoprotein; pfam02441 290340006656 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290340006657 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 290340006658 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 290340006659 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290340006660 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290340006661 catalytic site [active] 290340006662 G-X2-G-X-G-K; other site 290340006663 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 290340006664 active site 290340006665 dimer interface [polypeptide binding]; other site 290340006666 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 290340006667 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340006668 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340006669 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290340006670 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340006671 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340006672 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290340006673 IMP binding site; other site 290340006674 dimer interface [polypeptide binding]; other site 290340006675 interdomain contacts; other site 290340006676 partial ornithine binding site; other site 290340006677 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290340006678 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 290340006679 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290340006680 catalytic site [active] 290340006681 subunit interface [polypeptide binding]; other site 290340006682 dihydroorotase; Validated; Region: pyrC; PRK09357 290340006683 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340006684 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 290340006685 active site 290340006686 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 290340006687 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290340006688 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290340006689 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 290340006690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340006691 active site 290340006692 Protease prsW family; Region: PrsW-protease; pfam13367 290340006693 transcription antitermination factor NusB; Region: nusB; TIGR01951 290340006694 putative RNA binding site [nucleotide binding]; other site 290340006695 elongation factor P; Validated; Region: PRK00529 290340006696 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290340006697 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290340006698 RNA binding site [nucleotide binding]; other site 290340006699 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290340006700 RNA binding site [nucleotide binding]; other site 290340006701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290340006702 TPR motif; other site 290340006703 binding surface 290340006704 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290340006705 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290340006706 active site 290340006707 dimer interface [polypeptide binding]; other site 290340006708 metal binding site [ion binding]; metal-binding site 290340006709 shikimate kinase; Reviewed; Region: aroK; PRK00131 290340006710 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290340006711 ADP binding site [chemical binding]; other site 290340006712 magnesium binding site [ion binding]; other site 290340006713 putative shikimate binding site; other site 290340006714 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 290340006715 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290340006716 Tetramer interface [polypeptide binding]; other site 290340006717 active site 290340006718 FMN-binding site [chemical binding]; other site 290340006719 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290340006720 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340006721 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340006722 shikimate binding site; other site 290340006723 NAD(P) binding site [chemical binding]; other site 290340006724 YceG-like family; Region: YceG; pfam02618 290340006725 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 290340006726 dimerization interface [polypeptide binding]; other site 290340006727 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 290340006728 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290340006729 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 290340006730 motif 1; other site 290340006731 active site 290340006732 motif 2; other site 290340006733 motif 3; other site 290340006734 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 290340006735 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290340006736 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290340006737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340006738 RNA binding surface [nucleotide binding]; other site 290340006739 recombination factor protein RarA; Reviewed; Region: PRK13342 290340006740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006741 Walker A motif; other site 290340006742 ATP binding site [chemical binding]; other site 290340006743 Walker B motif; other site 290340006744 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290340006745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340006746 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340006747 Coenzyme A binding pocket [chemical binding]; other site 290340006748 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290340006749 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290340006750 dimer interface [polypeptide binding]; other site 290340006751 anticodon binding site; other site 290340006752 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 290340006753 homodimer interface [polypeptide binding]; other site 290340006754 motif 1; other site 290340006755 active site 290340006756 motif 2; other site 290340006757 GAD domain; Region: GAD; pfam02938 290340006758 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290340006759 active site 290340006760 motif 3; other site 290340006761 histidyl-tRNA synthetase; Region: hisS; TIGR00442 290340006762 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 290340006763 dimer interface [polypeptide binding]; other site 290340006764 motif 1; other site 290340006765 active site 290340006766 motif 2; other site 290340006767 motif 3; other site 290340006768 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290340006769 anticodon binding site; other site 290340006770 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290340006771 active site 290340006772 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006773 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006774 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290340006775 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 290340006776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290340006777 Zn2+ binding site [ion binding]; other site 290340006778 Mg2+ binding site [ion binding]; other site 290340006779 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290340006780 synthetase active site [active] 290340006781 NTP binding site [chemical binding]; other site 290340006782 metal binding site [ion binding]; metal-binding site 290340006783 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290340006784 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290340006785 protein-export membrane protein SecD; Region: secD; TIGR01129 290340006786 Protein export membrane protein; Region: SecD_SecF; cl14618 290340006787 Preprotein translocase subunit; Region: YajC; pfam02699 290340006788 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290340006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006790 Walker A motif; other site 290340006791 ATP binding site [chemical binding]; other site 290340006792 Walker B motif; other site 290340006793 arginine finger; other site 290340006794 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290340006795 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290340006796 RuvA N terminal domain; Region: RuvA_N; pfam01330 290340006797 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290340006798 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 290340006799 active site 290340006800 putative DNA-binding cleft [nucleotide binding]; other site 290340006801 dimer interface [polypeptide binding]; other site 290340006802 hypothetical protein; Validated; Region: PRK00110 290340006803 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 290340006804 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 290340006805 predicted active site [active] 290340006806 catalytic triad [active] 290340006807 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 290340006808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340006809 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 290340006810 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290340006811 catalytic triad [active] 290340006812 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 290340006813 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 290340006814 putative active site [active] 290340006815 putative metal binding site [ion binding]; other site 290340006816 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290340006817 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290340006818 active site 290340006819 multimer interface [polypeptide binding]; other site 290340006820 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290340006821 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 290340006822 nucleotide binding site/active site [active] 290340006823 HIT family signature motif; other site 290340006824 catalytic residue [active] 290340006825 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 290340006826 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 290340006827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 290340006828 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290340006829 active site 290340006830 dimer interface [polypeptide binding]; other site 290340006831 motif 1; other site 290340006832 motif 2; other site 290340006833 motif 3; other site 290340006834 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290340006835 anticodon binding site; other site 290340006836 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 290340006837 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 290340006838 active site 290340006839 PHP Thumb interface [polypeptide binding]; other site 290340006840 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290340006841 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290340006842 generic binding surface II; other site 290340006843 generic binding surface I; other site 290340006844 hypothetical protein; Provisional; Region: PRK06753 290340006845 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290340006846 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 290340006847 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340006848 catalytic residues [active] 290340006849 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 290340006850 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340006851 NAD binding site [chemical binding]; other site 290340006852 catalytic Zn binding site [ion binding]; other site 290340006853 substrate binding site [chemical binding]; other site 290340006854 structural Zn binding site [ion binding]; other site 290340006855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340006856 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290340006857 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290340006858 putative molybdopterin cofactor binding site [chemical binding]; other site 290340006859 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290340006860 putative molybdopterin cofactor binding site; other site 290340006861 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290340006862 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 290340006863 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340006864 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340006865 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290340006866 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290340006867 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290340006868 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340006869 iron-sulfur cluster [ion binding]; other site 290340006870 [2Fe-2S] cluster binding site [ion binding]; other site 290340006871 A new structural DNA glycosylase; Region: AlkD_like; cl11434 290340006872 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290340006873 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340006874 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340006875 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290340006876 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340006878 Walker A/P-loop; other site 290340006879 ATP binding site [chemical binding]; other site 290340006880 Q-loop/lid; other site 290340006881 ABC transporter signature motif; other site 290340006882 Walker B; other site 290340006883 D-loop; other site 290340006884 H-loop/switch region; other site 290340006885 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290340006886 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 290340006887 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290340006888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340006889 NAD(P) binding site [chemical binding]; other site 290340006890 active site 290340006891 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290340006892 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290340006893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340006894 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340006895 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 290340006896 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290340006897 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 290340006898 dimer interface [polypeptide binding]; other site 290340006899 active site 290340006900 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340006901 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 290340006902 active site 290340006903 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 290340006904 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290340006905 dimer interface [polypeptide binding]; other site 290340006906 putative radical transfer pathway; other site 290340006907 diiron center [ion binding]; other site 290340006908 tyrosyl radical; other site 290340006909 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 290340006910 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 290340006911 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290340006912 active site 290340006913 dimer interface [polypeptide binding]; other site 290340006914 catalytic residues [active] 290340006915 effector binding site; other site 290340006916 R2 peptide binding site; other site 290340006917 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 290340006918 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340006919 catalytic residues [active] 290340006920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340006921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340006922 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340006923 putative dimerization interface [polypeptide binding]; other site 290340006924 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 290340006925 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290340006926 metal ion-dependent adhesion site (MIDAS); other site 290340006927 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290340006928 metal ion-dependent adhesion site (MIDAS); other site 290340006929 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340006930 Protein of unknown function DUF58; Region: DUF58; pfam01882 290340006931 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340006932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340006933 Walker A motif; other site 290340006934 ATP binding site [chemical binding]; other site 290340006935 Walker B motif; other site 290340006936 arginine finger; other site 290340006937 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340006938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340006939 dimer interface [polypeptide binding]; other site 290340006940 conserved gate region; other site 290340006941 putative PBP binding loops; other site 290340006942 ABC-ATPase subunit interface; other site 290340006943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340006944 dimer interface [polypeptide binding]; other site 290340006945 conserved gate region; other site 290340006946 putative PBP binding loops; other site 290340006947 ABC-ATPase subunit interface; other site 290340006948 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340006949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340006950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340006951 putative DNA binding site [nucleotide binding]; other site 290340006952 putative Zn2+ binding site [ion binding]; other site 290340006953 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340006954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340006955 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 290340006956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340006957 S-adenosylmethionine binding site [chemical binding]; other site 290340006958 Cupin domain; Region: Cupin_2; cl17218 290340006959 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 290340006960 DNA topoisomerase 2; Provisional; Region: PLN03237 290340006961 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290340006962 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290340006963 active site 290340006964 (T/H)XGH motif; other site 290340006965 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290340006966 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290340006967 putative catalytic cysteine [active] 290340006968 gamma-glutamyl kinase; Provisional; Region: PRK05429 290340006969 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290340006970 nucleotide binding site [chemical binding]; other site 290340006971 homotetrameric interface [polypeptide binding]; other site 290340006972 putative phosphate binding site [ion binding]; other site 290340006973 putative allosteric binding site; other site 290340006974 PUA domain; Region: PUA; pfam01472 290340006975 GTPase CgtA; Reviewed; Region: obgE; PRK12296 290340006976 GTP1/OBG; Region: GTP1_OBG; pfam01018 290340006977 Obg GTPase; Region: Obg; cd01898 290340006978 G1 box; other site 290340006979 GTP/Mg2+ binding site [chemical binding]; other site 290340006980 Switch I region; other site 290340006981 G2 box; other site 290340006982 G3 box; other site 290340006983 Switch II region; other site 290340006984 G4 box; other site 290340006985 G5 box; other site 290340006986 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 290340006987 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 290340006988 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 290340006989 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 290340006990 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290340006991 dimer interface [polypeptide binding]; other site 290340006992 substrate binding site [chemical binding]; other site 290340006993 ATP binding site [chemical binding]; other site 290340006994 Putative transcription activator [Transcription]; Region: TenA; COG0819 290340006995 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 290340006996 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290340006997 homodimer interface [polypeptide binding]; other site 290340006998 oligonucleotide binding site [chemical binding]; other site 290340006999 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 290340007000 putative active site [active] 290340007001 redox center [active] 290340007002 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290340007003 active site 290340007004 multimer interface [polypeptide binding]; other site 290340007005 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 290340007006 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 290340007007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290340007008 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290340007009 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 290340007010 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290340007011 HIGH motif; other site 290340007012 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290340007013 active site 290340007014 KMSKS motif; other site 290340007015 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 290340007016 tRNA binding surface [nucleotide binding]; other site 290340007017 anticodon binding site; other site 290340007018 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340007019 putative catalytic site [active] 290340007020 putative metal binding site [ion binding]; other site 290340007021 putative phosphate binding site [ion binding]; other site 290340007022 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340007023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007024 NAD(P) binding site [chemical binding]; other site 290340007025 active site 290340007026 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 290340007027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340007028 active site 290340007029 HIGH motif; other site 290340007030 nucleotide binding site [chemical binding]; other site 290340007031 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340007032 active site 290340007033 KMSKS motif; other site 290340007034 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290340007035 tRNA binding surface [nucleotide binding]; other site 290340007036 anticodon binding site; other site 290340007037 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340007038 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 290340007039 putative DNA binding site [nucleotide binding]; other site 290340007040 catalytic residue [active] 290340007041 putative H2TH interface [polypeptide binding]; other site 290340007042 putative catalytic residues [active] 290340007043 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340007044 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290340007045 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340007046 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340007047 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290340007048 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 290340007049 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290340007050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340007051 Walker A motif; other site 290340007052 ATP binding site [chemical binding]; other site 290340007053 Walker B motif; other site 290340007054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290340007055 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 290340007056 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290340007057 oligomer interface [polypeptide binding]; other site 290340007058 active site residues [active] 290340007059 Clp protease; Region: CLP_protease; pfam00574 290340007060 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290340007061 oligomer interface [polypeptide binding]; other site 290340007062 active site residues [active] 290340007063 trigger factor; Provisional; Region: tig; PRK01490 290340007064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290340007065 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290340007066 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290340007067 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 290340007068 putative DNA binding site [nucleotide binding]; other site 290340007069 catalytic residue [active] 290340007070 putative H2TH interface [polypeptide binding]; other site 290340007071 putative catalytic residues [active] 290340007072 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340007073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290340007074 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 290340007075 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290340007076 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290340007077 Zn binding site [ion binding]; other site 290340007078 OsmC-like protein; Region: OsmC; cl00767 290340007079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340007080 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290340007081 NAD(P) binding site [chemical binding]; other site 290340007082 active site 290340007083 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290340007084 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290340007085 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 290340007086 apolar tunnel; other site 290340007087 heme binding site [chemical binding]; other site 290340007088 dimerization interface [polypeptide binding]; other site 290340007089 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 290340007090 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290340007091 active site 290340007092 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290340007093 catalytic triad [active] 290340007094 dimer interface [polypeptide binding]; other site 290340007095 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 290340007096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340007097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340007098 ABC transporter; Region: ABC_tran_2; pfam12848 290340007099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340007100 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340007101 dimer interface [polypeptide binding]; other site 290340007102 ssDNA binding site [nucleotide binding]; other site 290340007103 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290340007104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340007105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340007106 Coenzyme A binding pocket [chemical binding]; other site 290340007107 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340007108 active site 290340007109 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290340007110 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 290340007111 active site 290340007112 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 290340007113 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 290340007114 catalytic site [active] 290340007115 putative active site [active] 290340007116 putative substrate binding site [chemical binding]; other site 290340007117 dimer interface [polypeptide binding]; other site 290340007118 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290340007119 active site 290340007120 catalytic residues [active] 290340007121 metal binding site [ion binding]; metal-binding site 290340007122 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 290340007123 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 290340007124 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290340007125 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290340007126 hypothetical protein; Validated; Region: PRK02101 290340007127 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 290340007128 Putative zinc ribbon domain; Region: DUF164; pfam02591 290340007129 Uncharacterized conserved protein [Function unknown]; Region: COG0327 290340007130 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 290340007131 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 290340007132 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340007133 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340007134 dimer interface [polypeptide binding]; other site 290340007135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007136 catalytic residue [active] 290340007137 serine O-acetyltransferase; Region: cysE; TIGR01172 290340007138 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290340007139 trimer interface [polypeptide binding]; other site 290340007140 active site 290340007141 substrate binding site [chemical binding]; other site 290340007142 CoA binding site [chemical binding]; other site 290340007143 short chain dehydrogenase; Validated; Region: PRK06182 290340007144 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290340007145 NADP binding site [chemical binding]; other site 290340007146 active site 290340007147 steroid binding site; other site 290340007148 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340007149 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 290340007150 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 290340007151 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340007152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 290340007153 DNA-binding site [nucleotide binding]; DNA binding site 290340007154 FCD domain; Region: FCD; pfam07729 290340007155 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 290340007156 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 290340007157 putative NAD(P) binding site [chemical binding]; other site 290340007158 catalytic Zn binding site [ion binding]; other site 290340007159 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 290340007160 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290340007161 NADP binding site [chemical binding]; other site 290340007162 homodimer interface [polypeptide binding]; other site 290340007163 active site 290340007164 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290340007165 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340007166 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 290340007167 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340007168 NAD binding site [chemical binding]; other site 290340007169 ligand binding site [chemical binding]; other site 290340007170 catalytic site [active] 290340007171 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290340007172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007173 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340007174 putative substrate translocation pore; other site 290340007175 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340007176 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340007177 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340007178 NAD-dependent deacetylase; Provisional; Region: PRK05333 290340007179 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290340007180 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290340007181 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 290340007182 dimer interface [polypeptide binding]; other site 290340007183 catalytic triad [active] 290340007184 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 290340007185 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290340007186 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290340007187 dimer interface [polypeptide binding]; other site 290340007188 TPP-binding site [chemical binding]; other site 290340007189 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340007190 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340007191 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290340007192 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290340007193 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290340007194 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290340007195 dimer interface [polypeptide binding]; other site 290340007196 active site 290340007197 CoA binding pocket [chemical binding]; other site 290340007198 acyl carrier protein; Provisional; Region: acpP; PRK00982 290340007199 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290340007200 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290340007201 dimer interface [polypeptide binding]; other site 290340007202 active site 290340007203 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 290340007204 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290340007205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340007206 active site 290340007207 DNA binding site [nucleotide binding] 290340007208 Int/Topo IB signature motif; other site 290340007209 DNA protecting protein DprA; Region: dprA; TIGR00732 290340007210 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290340007211 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 290340007212 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290340007213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340007214 Walker A motif; other site 290340007215 ATP binding site [chemical binding]; other site 290340007216 Walker B motif; other site 290340007217 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290340007218 hypothetical protein; Reviewed; Region: PRK12497 290340007219 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 290340007220 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290340007221 RNA/DNA hybrid binding site [nucleotide binding]; other site 290340007222 active site 290340007223 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 290340007224 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 290340007225 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290340007226 RimM N-terminal domain; Region: RimM; pfam01782 290340007227 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 290340007228 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 290340007229 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 290340007230 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 290340007231 putative metal binding site [ion binding]; other site 290340007232 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340007233 active site 290340007234 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340007235 Amidohydrolase; Region: Amidohydro_4; pfam13147 290340007236 active site 290340007237 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290340007238 ThiC-associated domain; Region: ThiC-associated; pfam13667 290340007239 ThiC family; Region: ThiC; pfam01964 290340007240 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340007241 signal recognition particle protein; Provisional; Region: PRK10867 290340007242 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 290340007243 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290340007244 P loop; other site 290340007245 GTP binding site [chemical binding]; other site 290340007246 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290340007247 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 290340007248 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290340007249 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290340007250 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 290340007251 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290340007252 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 290340007253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340007255 putative substrate translocation pore; other site 290340007256 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290340007257 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 290340007258 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340007259 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290340007260 AAA domain; Region: AAA_23; pfam13476 290340007261 Walker A/P-loop; other site 290340007262 ATP binding site [chemical binding]; other site 290340007263 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290340007264 ABC transporter signature motif; other site 290340007265 Walker B; other site 290340007266 D-loop; other site 290340007267 H-loop/switch region; other site 290340007268 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340007269 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340007270 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340007271 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340007272 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340007273 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340007274 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340007275 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340007276 translocation protein TolB; Provisional; Region: tolB; PRK03629 290340007277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340007279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007280 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 290340007281 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 290340007282 DNA binding site [nucleotide binding] 290340007283 catalytic residue [active] 290340007284 H2TH interface [polypeptide binding]; other site 290340007285 putative catalytic residues [active] 290340007286 turnover-facilitating residue; other site 290340007287 intercalation triad [nucleotide binding]; other site 290340007288 8OG recognition residue [nucleotide binding]; other site 290340007289 putative reading head residues; other site 290340007290 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290340007291 ribonuclease III; Reviewed; Region: rnc; PRK00102 290340007292 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 290340007293 dimerization interface [polypeptide binding]; other site 290340007294 active site 290340007295 metal binding site [ion binding]; metal-binding site 290340007296 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 290340007297 dsRNA binding site [nucleotide binding]; other site 290340007298 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 290340007299 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 290340007300 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290340007301 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290340007302 active site 290340007303 (T/H)XGH motif; other site 290340007304 aminotransferase; Validated; Region: PRK07777 290340007305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340007306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007307 homodimer interface [polypeptide binding]; other site 290340007308 catalytic residue [active] 290340007309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340007310 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 290340007311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340007312 S-adenosylmethionine binding site [chemical binding]; other site 290340007313 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290340007314 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290340007315 generic binding surface II; other site 290340007316 ssDNA binding site; other site 290340007317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007318 ATP binding site [chemical binding]; other site 290340007319 putative Mg++ binding site [ion binding]; other site 290340007320 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007321 nucleotide binding region [chemical binding]; other site 290340007322 ATP-binding site [chemical binding]; other site 290340007323 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 290340007324 DAK2 domain; Region: Dak2; pfam02734 290340007325 thiamine monophosphate kinase; Provisional; Region: PRK05731 290340007326 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290340007327 ATP binding site [chemical binding]; other site 290340007328 dimerization interface [polypeptide binding]; other site 290340007329 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 290340007330 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290340007331 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290340007332 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290340007333 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290340007334 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290340007335 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290340007336 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290340007337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290340007338 putative acyl-acceptor binding pocket; other site 290340007339 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290340007340 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290340007341 hinge; other site 290340007342 active site 290340007343 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 290340007344 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290340007345 substrate binding site [chemical binding]; other site 290340007346 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290340007347 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290340007348 substrate binding site [chemical binding]; other site 290340007349 ligand binding site [chemical binding]; other site 290340007350 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340007351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340007352 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340007353 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 290340007354 YfjP GTPase; Region: YfjP; cd11383 290340007355 G1 box; other site 290340007356 GTP/Mg2+ binding site [chemical binding]; other site 290340007357 Switch I region; other site 290340007358 G2 box; other site 290340007359 Switch II region; other site 290340007360 G3 box; other site 290340007361 G4 box; other site 290340007362 G5 box; other site 290340007363 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290340007364 G1 box; other site 290340007365 GTP/Mg2+ binding site [chemical binding]; other site 290340007366 G2 box; other site 290340007367 Switch I region; other site 290340007368 G3 box; other site 290340007369 Switch II region; other site 290340007370 G5 box; other site 290340007371 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 290340007372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340007373 motif II; other site 290340007374 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290340007375 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290340007376 HIGH motif; other site 290340007377 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290340007378 active site 290340007379 KMSKS motif; other site 290340007380 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340007381 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 290340007382 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340007383 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340007384 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 290340007385 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290340007386 homodimer interface [polypeptide binding]; other site 290340007387 substrate-cofactor binding pocket; other site 290340007388 catalytic residue [active] 290340007389 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 290340007390 tartrate dehydrogenase; Region: TTC; TIGR02089 290340007391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340007392 Histidine kinase; Region: HisKA_3; pfam07730 290340007393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340007394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340007395 active site 290340007396 phosphorylation site [posttranslational modification] 290340007397 intermolecular recognition site; other site 290340007398 dimerization interface [polypeptide binding]; other site 290340007399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340007400 DNA binding residues [nucleotide binding] 290340007401 dimerization interface [polypeptide binding]; other site 290340007402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340007403 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290340007404 Walker A/P-loop; other site 290340007405 ATP binding site [chemical binding]; other site 290340007406 Q-loop/lid; other site 290340007407 ABC transporter signature motif; other site 290340007408 Walker B; other site 290340007409 D-loop; other site 290340007410 H-loop/switch region; other site 290340007411 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340007412 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290340007413 FtsX-like permease family; Region: FtsX; pfam02687 290340007414 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290340007415 FtsX-like permease family; Region: FtsX; pfam02687 290340007416 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 290340007417 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290340007418 active site 290340007419 HIGH motif; other site 290340007420 KMSKS motif; other site 290340007421 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290340007422 tRNA binding surface [nucleotide binding]; other site 290340007423 anticodon binding site; other site 290340007424 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290340007425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340007426 Walker A/P-loop; other site 290340007427 ATP binding site [chemical binding]; other site 290340007428 Q-loop/lid; other site 290340007429 ABC transporter signature motif; other site 290340007430 Walker B; other site 290340007431 D-loop; other site 290340007432 H-loop/switch region; other site 290340007433 FtsX-like permease family; Region: FtsX; pfam02687 290340007434 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 290340007435 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 290340007436 ligand binding site [chemical binding]; other site 290340007437 NAD binding site [chemical binding]; other site 290340007438 dimerization interface [polypeptide binding]; other site 290340007439 catalytic site [active] 290340007440 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 290340007441 putative L-serine binding site [chemical binding]; other site 290340007442 ketol-acid reductoisomerase; Provisional; Region: PRK05479 290340007443 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 290340007444 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290340007445 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290340007446 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290340007447 putative valine binding site [chemical binding]; other site 290340007448 dimer interface [polypeptide binding]; other site 290340007449 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290340007450 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 290340007451 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340007452 PYR/PP interface [polypeptide binding]; other site 290340007453 dimer interface [polypeptide binding]; other site 290340007454 TPP binding site [chemical binding]; other site 290340007455 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340007456 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290340007457 TPP-binding site [chemical binding]; other site 290340007458 dimer interface [polypeptide binding]; other site 290340007459 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 290340007460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340007461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340007462 putative DNA binding site [nucleotide binding]; other site 290340007463 putative Zn2+ binding site [ion binding]; other site 290340007464 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290340007465 putative dimerization interface [polypeptide binding]; other site 290340007466 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290340007467 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290340007468 MarR family; Region: MarR; pfam01047 290340007469 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290340007470 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290340007471 catalytic triad [active] 290340007472 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290340007473 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290340007474 peptide binding site [polypeptide binding]; other site 290340007475 malate:quinone oxidoreductase; Validated; Region: PRK05257 290340007476 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 290340007477 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290340007478 Protein export membrane protein; Region: SecD_SecF; cl14618 290340007479 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290340007480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340007481 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 290340007482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340007483 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 290340007484 MarR family; Region: MarR_2; cl17246 290340007485 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290340007486 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290340007487 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290340007488 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 290340007489 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290340007490 transmembrane helices; other site 290340007491 Electron transfer DM13; Region: DM13; pfam10517 290340007492 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340007493 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340007494 Predicted membrane protein [Function unknown]; Region: COG2246 290340007495 GtrA-like protein; Region: GtrA; pfam04138 290340007496 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290340007497 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290340007498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007499 catalytic residue [active] 290340007500 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 290340007501 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290340007502 dimerization interface [polypeptide binding]; other site 290340007503 active site 290340007504 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 290340007505 L-aspartate oxidase; Provisional; Region: PRK06175 290340007506 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290340007507 quinolinate synthetase; Provisional; Region: PRK09375 290340007508 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 290340007509 nudix motif; other site 290340007510 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 290340007511 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290340007512 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290340007513 AsnC family; Region: AsnC_trans_reg; pfam01037 290340007514 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290340007515 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340007516 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340007517 tetramer interface [polypeptide binding]; other site 290340007518 TPP-binding site [chemical binding]; other site 290340007519 heterodimer interface [polypeptide binding]; other site 290340007520 phosphorylation loop region [posttranslational modification] 290340007521 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340007522 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340007523 alpha subunit interface [polypeptide binding]; other site 290340007524 TPP binding site [chemical binding]; other site 290340007525 heterodimer interface [polypeptide binding]; other site 290340007526 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340007527 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340007528 E3 interaction surface; other site 290340007529 lipoyl attachment site [posttranslational modification]; other site 290340007530 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290340007531 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340007532 catalytic site [active] 290340007533 Retinoic acid induced 16-like protein; Region: RAI16-like; pfam10257 290340007534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340007535 active site 290340007536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007537 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340007538 putative substrate translocation pore; other site 290340007539 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340007540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340007541 putative DNA binding site [nucleotide binding]; other site 290340007542 dimerization interface [polypeptide binding]; other site 290340007543 putative Zn2+ binding site [ion binding]; other site 290340007544 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340007545 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340007546 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290340007547 Na binding site [ion binding]; other site 290340007548 Helix-turn-helix domain; Region: HTH_18; pfam12833 290340007549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340007550 Sulfatase; Region: Sulfatase; cl17466 290340007551 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290340007552 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340007553 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290340007554 Walker A/P-loop; other site 290340007555 ATP binding site [chemical binding]; other site 290340007556 Q-loop/lid; other site 290340007557 ABC transporter signature motif; other site 290340007558 Walker B; other site 290340007559 D-loop; other site 290340007560 H-loop/switch region; other site 290340007561 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340007563 dimer interface [polypeptide binding]; other site 290340007564 conserved gate region; other site 290340007565 putative PBP binding loops; other site 290340007566 ABC-ATPase subunit interface; other site 290340007567 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340007568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340007569 NMT1/THI5 like; Region: NMT1; pfam09084 290340007570 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340007571 substrate binding pocket [chemical binding]; other site 290340007572 membrane-bound complex binding site; other site 290340007573 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340007574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340007575 active site 290340007576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340007577 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 290340007578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340007579 Walker A/P-loop; other site 290340007580 ATP binding site [chemical binding]; other site 290340007581 Q-loop/lid; other site 290340007582 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 290340007583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340007584 ABC transporter signature motif; other site 290340007585 Walker B; other site 290340007586 D-loop; other site 290340007587 H-loop/switch region; other site 290340007588 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 290340007589 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290340007590 active site 290340007591 metal binding site [ion binding]; metal-binding site 290340007592 DNA binding site [nucleotide binding] 290340007593 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290340007594 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290340007595 amphipathic channel; other site 290340007596 Asn-Pro-Ala signature motifs; other site 290340007597 Domain of unknown function (DUF202); Region: DUF202; pfam02656 290340007598 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340007599 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 290340007600 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 290340007601 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 290340007602 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 290340007603 active site 290340007604 catalytic site [active] 290340007605 substrate binding site [chemical binding]; other site 290340007606 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 290340007607 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290340007608 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290340007609 Walker A/P-loop; other site 290340007610 ATP binding site [chemical binding]; other site 290340007611 Q-loop/lid; other site 290340007612 ABC transporter signature motif; other site 290340007613 Walker B; other site 290340007614 D-loop; other site 290340007615 H-loop/switch region; other site 290340007616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340007617 DNA-binding site [nucleotide binding]; DNA binding site 290340007618 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290340007619 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340007620 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290340007621 dimerization interface [polypeptide binding]; other site 290340007622 active site 290340007623 ribonuclease PH; Reviewed; Region: rph; PRK00173 290340007624 Ribonuclease PH; Region: RNase_PH_bact; cd11362 290340007625 hexamer interface [polypeptide binding]; other site 290340007626 active site 290340007627 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 290340007628 glutamate racemase; Provisional; Region: PRK00865 290340007629 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 290340007630 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 290340007631 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 290340007632 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 290340007633 active site 290340007634 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 290340007635 Isochorismatase family; Region: Isochorismatase; pfam00857 290340007636 catalytic triad [active] 290340007637 conserved cis-peptide bond; other site 290340007638 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290340007639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007640 ATP binding site [chemical binding]; other site 290340007641 putative Mg++ binding site [ion binding]; other site 290340007642 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 290340007643 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290340007644 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290340007645 active site 290340007646 trimer interface [polypeptide binding]; other site 290340007647 allosteric site; other site 290340007648 active site lid [active] 290340007649 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290340007650 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290340007651 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290340007652 Walker A/P-loop; other site 290340007653 ATP binding site [chemical binding]; other site 290340007654 Q-loop/lid; other site 290340007655 ABC transporter signature motif; other site 290340007656 Walker B; other site 290340007657 D-loop; other site 290340007658 H-loop/switch region; other site 290340007659 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290340007660 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 290340007661 active site 290340007662 FMN binding site [chemical binding]; other site 290340007663 substrate binding site [chemical binding]; other site 290340007664 homotetramer interface [polypeptide binding]; other site 290340007665 catalytic residue [active] 290340007666 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290340007667 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340007668 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290340007669 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290340007670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340007671 hypothetical protein; Provisional; Region: PRK03298 290340007672 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290340007673 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340007674 active site 290340007675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290340007676 DNA-binding site [nucleotide binding]; DNA binding site 290340007677 RNA-binding motif; other site 290340007678 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 290340007679 Putative esterase; Region: Esterase; pfam00756 290340007680 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 290340007681 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290340007682 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290340007683 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290340007684 alpha subunit interaction interface [polypeptide binding]; other site 290340007685 Walker A motif; other site 290340007686 ATP binding site [chemical binding]; other site 290340007687 Walker B motif; other site 290340007688 inhibitor binding site; inhibition site 290340007689 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290340007690 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 290340007691 core domain interface [polypeptide binding]; other site 290340007692 delta subunit interface [polypeptide binding]; other site 290340007693 epsilon subunit interface [polypeptide binding]; other site 290340007694 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290340007695 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290340007696 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290340007697 beta subunit interaction interface [polypeptide binding]; other site 290340007698 Walker A motif; other site 290340007699 ATP binding site [chemical binding]; other site 290340007700 Walker B motif; other site 290340007701 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290340007702 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290340007703 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 290340007704 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 290340007705 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 290340007706 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 290340007707 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 290340007708 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290340007709 Mg++ binding site [ion binding]; other site 290340007710 putative catalytic motif [active] 290340007711 substrate binding site [chemical binding]; other site 290340007712 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340007713 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007714 active site 290340007715 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290340007716 Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808 290340007717 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 290340007718 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290340007719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340007720 S-adenosylmethionine binding site [chemical binding]; other site 290340007721 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290340007722 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290340007723 RF-1 domain; Region: RF-1; pfam00472 290340007724 transcription termination factor Rho; Provisional; Region: PRK12608 290340007725 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290340007726 RNA binding site [nucleotide binding]; other site 290340007727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290340007728 Walker A motif; other site 290340007729 ATP binding site [chemical binding]; other site 290340007730 Walker B motif; other site 290340007731 homoserine kinase; Provisional; Region: PRK01212 290340007732 threonine synthase; Reviewed; Region: PRK06721 290340007733 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 290340007734 homodimer interface [polypeptide binding]; other site 290340007735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007736 catalytic residue [active] 290340007737 homoserine dehydrogenase; Provisional; Region: PRK06349 290340007738 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290340007739 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290340007740 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 290340007741 diaminopimelate decarboxylase; Region: lysA; TIGR01048 290340007742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290340007743 active site 290340007744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340007745 substrate binding site [chemical binding]; other site 290340007746 catalytic residues [active] 290340007747 dimer interface [polypeptide binding]; other site 290340007748 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 290340007749 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 290340007750 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290340007751 active site 290340007752 HIGH motif; other site 290340007753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290340007754 KMSK motif region; other site 290340007755 tRNA binding surface [nucleotide binding]; other site 290340007756 DALR anticodon binding domain; Region: DALR_1; smart00836 290340007757 anticodon binding site; other site 290340007758 FMN-binding domain; Region: FMN_bind; cl01081 290340007759 ApbE family; Region: ApbE; pfam02424 290340007760 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 290340007761 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 290340007762 FAD binding pocket [chemical binding]; other site 290340007763 conserved FAD binding motif [chemical binding]; other site 290340007764 phosphate binding motif [ion binding]; other site 290340007765 beta-alpha-beta structure motif; other site 290340007766 NAD binding pocket [chemical binding]; other site 290340007767 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 290340007768 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 290340007769 active site 290340007770 Zn binding site [ion binding]; other site 290340007771 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 290340007772 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290340007773 conserved cys residue [active] 290340007774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340007775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340007776 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 290340007777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340007778 ATP binding site [chemical binding]; other site 290340007779 putative Mg++ binding site [ion binding]; other site 290340007780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340007781 nucleotide binding region [chemical binding]; other site 290340007782 ATP-binding site [chemical binding]; other site 290340007783 Helicase associated domain (HA2); Region: HA2; pfam04408 290340007784 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 290340007785 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 290340007786 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 290340007787 nucleotide binding site/active site [active] 290340007788 HIT family signature motif; other site 290340007789 catalytic residue [active] 290340007790 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340007791 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290340007792 putative NAD(P) binding site [chemical binding]; other site 290340007793 putative substrate binding site [chemical binding]; other site 290340007794 catalytic Zn binding site [ion binding]; other site 290340007795 structural Zn binding site [ion binding]; other site 290340007796 dimer interface [polypeptide binding]; other site 290340007797 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290340007798 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290340007799 active site residue [active] 290340007800 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290340007801 active site residue [active] 290340007802 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340007803 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290340007804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007805 catalytic residue [active] 290340007806 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290340007807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340007808 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290340007809 metal binding site 2 [ion binding]; metal-binding site 290340007810 putative DNA binding helix; other site 290340007811 metal binding site 1 [ion binding]; metal-binding site 290340007812 dimer interface [polypeptide binding]; other site 290340007813 structural Zn2+ binding site [ion binding]; other site 290340007814 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290340007815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340007816 putative PBP binding regions; other site 290340007817 ABC-ATPase subunit interface; other site 290340007818 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340007819 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290340007820 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340007821 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290340007822 intersubunit interface [polypeptide binding]; other site 290340007823 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340007824 FOG: CBS domain [General function prediction only]; Region: COG0517 290340007825 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340007826 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340007827 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340007828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340007829 Transporter associated domain; Region: CorC_HlyC; smart01091 290340007830 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 290340007831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290340007832 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290340007833 TPP-binding site [chemical binding]; other site 290340007834 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290340007835 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 290340007836 active site 290340007837 catalytic triad [active] 290340007838 oxyanion hole [active] 290340007839 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340007840 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340007841 Uncharacterized conserved protein [Function unknown]; Region: COG3595 290340007842 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340007843 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340007844 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340007845 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 290340007846 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 290340007847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340007848 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340007849 DNA binding residues [nucleotide binding] 290340007850 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 290340007851 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290340007852 hinge; other site 290340007853 active site 290340007854 Predicted GTPases [General function prediction only]; Region: COG1162 290340007855 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290340007856 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290340007857 GTP/Mg2+ binding site [chemical binding]; other site 290340007858 G4 box; other site 290340007859 G5 box; other site 290340007860 G1 box; other site 290340007861 Switch I region; other site 290340007862 G2 box; other site 290340007863 G3 box; other site 290340007864 Switch II region; other site 290340007865 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290340007866 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 290340007867 active site 290340007868 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290340007869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340007870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340007871 catalytic residue [active] 290340007872 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290340007873 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290340007874 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340007875 FeoA domain; Region: FeoA; pfam04023 290340007876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340007878 putative substrate translocation pore; other site 290340007879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340007880 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290340007881 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290340007882 protein binding site [polypeptide binding]; other site 290340007883 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290340007884 SmpB-tmRNA interface; other site 290340007885 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340007886 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340007887 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 290340007888 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 290340007889 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 290340007890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340007891 Walker A/P-loop; other site 290340007892 ATP binding site [chemical binding]; other site 290340007893 Q-loop/lid; other site 290340007894 ABC transporter signature motif; other site 290340007895 Walker B; other site 290340007896 D-loop; other site 290340007897 H-loop/switch region; other site 290340007898 peptide chain release factor 2; Validated; Region: prfB; PRK00578 290340007899 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290340007900 RF-1 domain; Region: RF-1; pfam00472 290340007901 TadE-like protein; Region: TadE; pfam07811 290340007902 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290340007903 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290340007904 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290340007905 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290340007906 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 290340007907 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340007908 ATP binding site [chemical binding]; other site 290340007909 Walker A motif; other site 290340007910 hexamer interface [polypeptide binding]; other site 290340007911 Walker B motif; other site 290340007912 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 290340007913 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 290340007914 active site 290340007915 Family description; Region: VCBS; pfam13517 290340007916 Family description; Region: VCBS; pfam13517 290340007917 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 290340007918 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 290340007919 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 290340007920 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 290340007921 Family description; Region: VCBS; pfam13517 290340007922 Family description; Region: VCBS; pfam13517 290340007923 FG-GAP repeat; Region: FG-GAP; pfam01839 290340007924 Family description; Region: VCBS; pfam13517 290340007925 FG-GAP repeat; Region: FG-GAP; pfam01839 290340007926 Family description; Region: VCBS; pfam13517 290340007927 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290340007928 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007929 active site 290340007930 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 290340007931 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 290340007932 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 290340007933 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 290340007934 Walker A/P-loop; other site 290340007935 ATP binding site [chemical binding]; other site 290340007936 Q-loop/lid; other site 290340007937 ABC transporter signature motif; other site 290340007938 Walker B; other site 290340007939 D-loop; other site 290340007940 H-loop/switch region; other site 290340007941 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 290340007942 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290340007943 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290340007944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340007945 active site 290340007946 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 290340007947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340007948 UDP-galactopyranose mutase; Region: GLF; pfam03275 290340007949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340007950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340007951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340007952 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290340007953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290340007954 inhibitor-cofactor binding pocket; inhibition site 290340007955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340007956 catalytic residue [active] 290340007957 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340007958 putative trimer interface [polypeptide binding]; other site 290340007959 putative CoA binding site [chemical binding]; other site 290340007960 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 290340007961 putative trimer interface [polypeptide binding]; other site 290340007962 putative active site [active] 290340007963 putative substrate binding site [chemical binding]; other site 290340007964 putative CoA binding site [chemical binding]; other site 290340007965 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340007966 phosphopeptide binding site; other site 290340007967 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 290340007968 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290340007969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290340007970 Transcription factor WhiB; Region: Whib; pfam02467 290340007971 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 290340007972 PAS fold; Region: PAS_4; pfam08448 290340007973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290340007974 Histidine kinase; Region: HisKA_2; pfam07568 290340007975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340007976 ATP binding site [chemical binding]; other site 290340007977 Mg2+ binding site [ion binding]; other site 290340007978 G-X-G motif; other site 290340007979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340007980 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 290340007981 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290340007982 Helix-turn-helix domain; Region: HTH_17; pfam12728 290340007983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340007984 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 290340007985 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 290340007986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 290340007987 nucleotide binding region [chemical binding]; other site 290340007988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 290340007989 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290340007990 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290340007991 30S subunit binding site; other site 290340007992 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 290340007993 lipoprotein LpqB; Provisional; Region: PRK13614 290340007994 Sporulation and spore germination; Region: Germane; pfam10646 290340007995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340007996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290340007997 dimerization interface [polypeptide binding]; other site 290340007998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340007999 dimer interface [polypeptide binding]; other site 290340008000 phosphorylation site [posttranslational modification] 290340008001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340008002 ATP binding site [chemical binding]; other site 290340008003 G-X-G motif; other site 290340008004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340008005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340008006 active site 290340008007 phosphorylation site [posttranslational modification] 290340008008 intermolecular recognition site; other site 290340008009 dimerization interface [polypeptide binding]; other site 290340008010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340008011 DNA binding site [nucleotide binding] 290340008012 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 290340008013 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 290340008014 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 290340008015 MoxR-like ATPases [General function prediction only]; Region: COG0714 290340008016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340008017 Walker A motif; other site 290340008018 ATP binding site [chemical binding]; other site 290340008019 Walker B motif; other site 290340008020 arginine finger; other site 290340008021 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 290340008022 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290340008023 Protein of unknown function DUF58; Region: DUF58; pfam01882 290340008024 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 290340008025 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 290340008026 chorismate mutase; Provisional; Region: PRK09239 290340008027 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340008028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340008029 Walker A/P-loop; other site 290340008030 ATP binding site [chemical binding]; other site 290340008031 Q-loop/lid; other site 290340008032 ABC transporter signature motif; other site 290340008033 Walker B; other site 290340008034 D-loop; other site 290340008035 H-loop/switch region; other site 290340008036 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340008037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340008038 Walker A/P-loop; other site 290340008039 ATP binding site [chemical binding]; other site 290340008040 Q-loop/lid; other site 290340008041 ABC transporter signature motif; other site 290340008042 Walker B; other site 290340008043 D-loop; other site 290340008044 H-loop/switch region; other site 290340008045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340008046 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340008047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008048 dimer interface [polypeptide binding]; other site 290340008049 conserved gate region; other site 290340008050 ABC-ATPase subunit interface; other site 290340008051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340008052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008053 dimer interface [polypeptide binding]; other site 290340008054 conserved gate region; other site 290340008055 putative PBP binding loops; other site 290340008056 ABC-ATPase subunit interface; other site 290340008057 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290340008058 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 290340008059 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 290340008060 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290340008061 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290340008062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340008063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340008064 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290340008065 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290340008066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340008067 catalytic residue [active] 290340008068 Predicted transcriptional regulator [Transcription]; Region: COG2345 290340008069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340008070 putative DNA binding site [nucleotide binding]; other site 290340008071 dimerization interface [polypeptide binding]; other site 290340008072 putative Zn2+ binding site [ion binding]; other site 290340008073 diacylglycerol kinase; Reviewed; Region: PRK11914 290340008074 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340008075 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290340008076 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 290340008077 HSP70 interaction site [polypeptide binding]; other site 290340008078 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 290340008079 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 290340008080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340008081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340008082 DNA binding residues [nucleotide binding] 290340008083 Anti-sigma-K factor rskA; Region: RskA; pfam10099 290340008084 GntP family permease; Region: GntP_permease; pfam02447 290340008085 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290340008086 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290340008087 AAA domain; Region: AAA_33; pfam13671 290340008088 ATP-binding site [chemical binding]; other site 290340008089 Gluconate-6-phosphate binding site [chemical binding]; other site 290340008090 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 290340008091 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290340008092 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 290340008093 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290340008094 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290340008095 Ligand Binding Site [chemical binding]; other site 290340008096 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290340008097 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290340008098 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290340008099 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290340008100 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 290340008101 UTRA domain; Region: UTRA; cl17743 290340008102 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290340008103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340008104 DNA-binding site [nucleotide binding]; DNA binding site 290340008105 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290340008106 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 290340008107 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 290340008108 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290340008109 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290340008110 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 290340008111 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 290340008112 Protein of unknown function DUF45; Region: DUF45; cl00636 290340008113 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 290340008114 Part of AAA domain; Region: AAA_19; pfam13245 290340008115 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340008116 Family description; Region: UvrD_C_2; pfam13538 290340008117 HRDC domain; Region: HRDC; pfam00570 290340008118 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 290340008119 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 290340008120 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 290340008121 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 290340008122 putative NADH binding site [chemical binding]; other site 290340008123 putative active site [active] 290340008124 nudix motif; other site 290340008125 putative metal binding site [ion binding]; other site 290340008126 Phosphotransferase enzyme family; Region: APH; pfam01636 290340008127 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290340008128 active site 290340008129 ATP binding site [chemical binding]; other site 290340008130 substrate binding site [chemical binding]; other site 290340008131 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340008132 Part of AAA domain; Region: AAA_19; pfam13245 290340008133 Family description; Region: UvrD_C_2; pfam13538 290340008134 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 290340008135 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290340008136 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 290340008137 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290340008138 DNA binding site [nucleotide binding] 290340008139 active site 290340008140 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290340008141 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 290340008142 active site 290340008143 catalytic site [active] 290340008144 substrate binding site [chemical binding]; other site 290340008145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340008146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340008147 substrate binding pocket [chemical binding]; other site 290340008148 membrane-bound complex binding site; other site 290340008149 hinge residues; other site 290340008150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340008152 dimer interface [polypeptide binding]; other site 290340008153 conserved gate region; other site 290340008154 putative PBP binding loops; other site 290340008155 ABC-ATPase subunit interface; other site 290340008156 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340008157 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340008158 Walker A/P-loop; other site 290340008159 ATP binding site [chemical binding]; other site 290340008160 Q-loop/lid; other site 290340008161 ABC transporter signature motif; other site 290340008162 Walker B; other site 290340008163 D-loop; other site 290340008164 H-loop/switch region; other site 290340008165 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340008166 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290340008167 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290340008168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340008169 inhibitor-cofactor binding pocket; inhibition site 290340008170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008171 catalytic residue [active] 290340008172 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290340008173 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290340008174 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 290340008175 dimer interface [polypeptide binding]; other site 290340008176 active site 290340008177 Schiff base residues; other site 290340008178 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290340008179 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 290340008180 domain interfaces; other site 290340008181 active site 290340008182 ferrochelatase; Reviewed; Region: hemH; PRK00035 290340008183 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290340008184 C-terminal domain interface [polypeptide binding]; other site 290340008185 active site 290340008186 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290340008187 active site 290340008188 N-terminal domain interface [polypeptide binding]; other site 290340008189 Chlorite dismutase; Region: Chlor_dismutase; cl01280 290340008190 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 290340008191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340008192 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290340008193 substrate binding site [chemical binding]; other site 290340008194 active site 290340008195 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290340008196 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 290340008197 NAD(P) binding pocket [chemical binding]; other site 290340008198 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290340008199 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 290340008200 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290340008201 ATP binding site [chemical binding]; other site 290340008202 substrate interface [chemical binding]; other site 290340008203 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340008204 active site residue [active] 290340008205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340008206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340008207 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 290340008208 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 290340008209 aromatic arch; other site 290340008210 DCoH dimer interaction site [polypeptide binding]; other site 290340008211 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 290340008212 DCoH tetramer interaction site [polypeptide binding]; other site 290340008213 substrate binding site [chemical binding]; other site 290340008214 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290340008215 ThiS interaction site; other site 290340008216 putative active site [active] 290340008217 tetramer interface [polypeptide binding]; other site 290340008218 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290340008219 thiS-thiF/thiG interaction site; other site 290340008220 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 290340008221 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290340008222 thiamine phosphate binding site [chemical binding]; other site 290340008223 active site 290340008224 pyrophosphate binding site [ion binding]; other site 290340008225 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 290340008226 TM2 domain; Region: TM2; pfam05154 290340008227 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 290340008228 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 290340008229 RNB domain; Region: RNB; pfam00773 290340008230 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290340008231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290340008232 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340008233 ATP binding site [chemical binding]; other site 290340008234 Mg++ binding site [ion binding]; other site 290340008235 motif III; other site 290340008236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340008237 nucleotide binding region [chemical binding]; other site 290340008238 ATP-binding site [chemical binding]; other site 290340008239 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290340008240 DNA methylase; Region: N6_N4_Mtase; pfam01555 290340008241 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 290340008242 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290340008243 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290340008244 active site 290340008245 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290340008246 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 290340008247 proline aminopeptidase P II; Provisional; Region: PRK10879 290340008248 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290340008249 active site 290340008250 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 290340008251 PRC-barrel domain; Region: PRC; pfam05239 290340008252 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 290340008253 MgtE intracellular N domain; Region: MgtE_N; smart00924 290340008254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290340008255 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 290340008256 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 290340008257 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 290340008258 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290340008259 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290340008260 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 290340008261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340008262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340008263 DNA binding residues [nucleotide binding] 290340008264 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340008265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290340008266 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 290340008267 DivIVA domain; Region: DivI1A_domain; TIGR03544 290340008268 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290340008269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340008270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340008271 Walker A/P-loop; other site 290340008272 ATP binding site [chemical binding]; other site 290340008273 Q-loop/lid; other site 290340008274 ABC transporter signature motif; other site 290340008275 Walker B; other site 290340008276 D-loop; other site 290340008277 H-loop/switch region; other site 290340008278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340008279 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340008280 substrate binding pocket [chemical binding]; other site 290340008281 membrane-bound complex binding site; other site 290340008282 hinge residues; other site 290340008283 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340008284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008285 dimer interface [polypeptide binding]; other site 290340008286 conserved gate region; other site 290340008287 putative PBP binding loops; other site 290340008288 ABC-ATPase subunit interface; other site 290340008289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008290 dimer interface [polypeptide binding]; other site 290340008291 conserved gate region; other site 290340008292 putative PBP binding loops; other site 290340008293 ABC-ATPase subunit interface; other site 290340008294 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 290340008295 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 290340008296 metal binding site [ion binding]; metal-binding site 290340008297 putative dimer interface [polypeptide binding]; other site 290340008298 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 290340008299 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 290340008300 putative trimer interface [polypeptide binding]; other site 290340008301 putative CoA binding site [chemical binding]; other site 290340008302 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290340008303 UDP-glucose 4-epimerase; Region: PLN02240 290340008304 NAD binding site [chemical binding]; other site 290340008305 homodimer interface [polypeptide binding]; other site 290340008306 active site 290340008307 substrate binding site [chemical binding]; other site 290340008308 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 290340008309 dimer interface [polypeptide binding]; other site 290340008310 Citrate synthase; Region: Citrate_synt; pfam00285 290340008311 active site 290340008312 citrylCoA binding site [chemical binding]; other site 290340008313 NADH binding [chemical binding]; other site 290340008314 cationic pore residues; other site 290340008315 oxalacetate/citrate binding site [chemical binding]; other site 290340008316 coenzyme A binding site [chemical binding]; other site 290340008317 catalytic triad [active] 290340008318 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 290340008319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340008320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008321 homodimer interface [polypeptide binding]; other site 290340008322 catalytic residue [active] 290340008323 Ferredoxin [Energy production and conversion]; Region: COG1146 290340008324 4Fe-4S binding domain; Region: Fer4; pfam00037 290340008325 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290340008326 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 290340008327 G1 box; other site 290340008328 putative GEF interaction site [polypeptide binding]; other site 290340008329 GTP/Mg2+ binding site [chemical binding]; other site 290340008330 Switch I region; other site 290340008331 G2 box; other site 290340008332 G3 box; other site 290340008333 Switch II region; other site 290340008334 G4 box; other site 290340008335 G5 box; other site 290340008336 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290340008337 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290340008338 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 290340008339 active site 290340008340 catalytic triad [active] 290340008341 oxyanion hole [active] 290340008342 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340008343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340008344 Walker A/P-loop; other site 290340008345 ATP binding site [chemical binding]; other site 290340008346 Q-loop/lid; other site 290340008347 ABC transporter signature motif; other site 290340008348 Walker B; other site 290340008349 D-loop; other site 290340008350 H-loop/switch region; other site 290340008351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290340008352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340008353 Walker A/P-loop; other site 290340008354 ATP binding site [chemical binding]; other site 290340008355 Q-loop/lid; other site 290340008356 ABC transporter signature motif; other site 290340008357 Walker B; other site 290340008358 D-loop; other site 290340008359 H-loop/switch region; other site 290340008360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340008361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340008362 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290340008363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008364 dimer interface [polypeptide binding]; other site 290340008365 conserved gate region; other site 290340008366 putative PBP binding loops; other site 290340008367 ABC-ATPase subunit interface; other site 290340008368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340008369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008370 dimer interface [polypeptide binding]; other site 290340008371 conserved gate region; other site 290340008372 putative PBP binding loops; other site 290340008373 ABC-ATPase subunit interface; other site 290340008374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290340008375 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290340008376 GTP-binding protein YchF; Reviewed; Region: PRK09601 290340008377 YchF GTPase; Region: YchF; cd01900 290340008378 G1 box; other site 290340008379 GTP/Mg2+ binding site [chemical binding]; other site 290340008380 Switch I region; other site 290340008381 G2 box; other site 290340008382 Switch II region; other site 290340008383 G3 box; other site 290340008384 G4 box; other site 290340008385 G5 box; other site 290340008386 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290340008387 RmuC family; Region: RmuC; pfam02646 290340008388 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290340008389 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290340008390 generic binding surface II; other site 290340008391 generic binding surface I; other site 290340008392 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 290340008393 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 290340008394 aminotransferase AlaT; Validated; Region: PRK09265 290340008395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340008396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008397 homodimer interface [polypeptide binding]; other site 290340008398 catalytic residue [active] 290340008399 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290340008400 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 290340008401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008402 ABC-ATPase subunit interface; other site 290340008403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008404 dimer interface [polypeptide binding]; other site 290340008405 conserved gate region; other site 290340008406 ABC-ATPase subunit interface; other site 290340008407 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290340008408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340008409 Walker A/P-loop; other site 290340008410 ATP binding site [chemical binding]; other site 290340008411 Q-loop/lid; other site 290340008412 ABC transporter signature motif; other site 290340008413 Walker B; other site 290340008414 D-loop; other site 290340008415 H-loop/switch region; other site 290340008416 GTPase RsgA; Reviewed; Region: PRK01889 290340008417 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290340008418 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290340008419 GTP/Mg2+ binding site [chemical binding]; other site 290340008420 G4 box; other site 290340008421 G5 box; other site 290340008422 G1 box; other site 290340008423 Switch I region; other site 290340008424 G2 box; other site 290340008425 G3 box; other site 290340008426 Switch II region; other site 290340008427 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 290340008428 nudix motif; other site 290340008429 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 290340008430 Pirin-related protein [General function prediction only]; Region: COG1741 290340008431 Pirin; Region: Pirin; pfam02678 290340008432 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290340008433 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 290340008434 Nitronate monooxygenase; Region: NMO; pfam03060 290340008435 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 290340008436 FMN binding site [chemical binding]; other site 290340008437 substrate binding site [chemical binding]; other site 290340008438 putative catalytic residue [active] 290340008439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340008440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340008441 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 290340008442 putative dimerization interface [polypeptide binding]; other site 290340008443 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340008444 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 290340008445 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340008446 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290340008447 putative DNA binding site [nucleotide binding]; other site 290340008448 putative Zn2+ binding site [ion binding]; other site 290340008449 AsnC family; Region: AsnC_trans_reg; pfam01037 290340008450 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340008451 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290340008452 dimerization interface [polypeptide binding]; other site 290340008453 putative DNA binding site [nucleotide binding]; other site 290340008454 putative Zn2+ binding site [ion binding]; other site 290340008455 AsnC family; Region: AsnC_trans_reg; pfam01037 290340008456 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 290340008457 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 290340008458 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 290340008459 oligomer interface [polypeptide binding]; other site 290340008460 metal binding site [ion binding]; metal-binding site 290340008461 metal binding site [ion binding]; metal-binding site 290340008462 putative Cl binding site [ion binding]; other site 290340008463 basic sphincter; other site 290340008464 hydrophobic gate; other site 290340008465 periplasmic entrance; other site 290340008466 Predicted ATPase [General function prediction only]; Region: COG1485 290340008467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340008468 Walker A motif; other site 290340008469 ATP binding site [chemical binding]; other site 290340008470 Walker B motif; other site 290340008471 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290340008472 Ferritin-like domain; Region: Ferritin; pfam00210 290340008473 ferroxidase diiron center [ion binding]; other site 290340008474 CrcB-like protein; Region: CRCB; cl09114 290340008475 CrcB-like protein; Region: CRCB; pfam02537 290340008476 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 290340008477 ABC1 family; Region: ABC1; cl17513 290340008478 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340008479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340008480 putative DNA binding site [nucleotide binding]; other site 290340008481 putative Zn2+ binding site [ion binding]; other site 290340008482 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340008483 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340008484 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 290340008485 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340008486 Catalytic site [active] 290340008487 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290340008488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340008489 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290340008490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340008491 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340008492 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290340008493 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290340008494 active site 290340008495 tetramer interface; other site 290340008496 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 290340008497 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 290340008498 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 290340008499 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 290340008500 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290340008501 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 290340008502 Part of AAA domain; Region: AAA_19; pfam13245 290340008503 GMP synthase; Reviewed; Region: guaA; PRK00074 290340008504 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290340008505 AMP/PPi binding site [chemical binding]; other site 290340008506 candidate oxyanion hole; other site 290340008507 catalytic triad [active] 290340008508 potential glutamine specificity residues [chemical binding]; other site 290340008509 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290340008510 ATP Binding subdomain [chemical binding]; other site 290340008511 Ligand Binding sites [chemical binding]; other site 290340008512 Dimerization subdomain; other site 290340008513 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 290340008514 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340008515 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340008516 active site 290340008517 phosphorylation site [posttranslational modification] 290340008518 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 290340008519 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290340008520 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 290340008521 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290340008522 active site 290340008523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340008524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340008525 Walker A/P-loop; other site 290340008526 ATP binding site [chemical binding]; other site 290340008527 Q-loop/lid; other site 290340008528 ABC transporter signature motif; other site 290340008529 Walker B; other site 290340008530 D-loop; other site 290340008531 H-loop/switch region; other site 290340008532 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290340008533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290340008534 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 290340008535 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290340008536 active site 290340008537 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290340008538 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290340008539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290340008540 Uncharacterized conserved protein [Function unknown]; Region: COG4095 290340008541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340008542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340008543 DNA binding residues [nucleotide binding] 290340008544 dimerization interface [polypeptide binding]; other site 290340008545 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290340008546 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290340008547 ring oligomerisation interface [polypeptide binding]; other site 290340008548 ATP/Mg binding site [chemical binding]; other site 290340008549 stacking interactions; other site 290340008550 hinge regions; other site 290340008551 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290340008552 oligomerisation interface [polypeptide binding]; other site 290340008553 mobile loop; other site 290340008554 roof hairpin; other site 290340008555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340008556 S-adenosylmethionine binding site [chemical binding]; other site 290340008557 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 290340008558 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340008559 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340008560 shikimate binding site; other site 290340008561 NAD(P) binding site [chemical binding]; other site 290340008562 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 290340008563 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 290340008564 carboxylate-amine ligase; Provisional; Region: PRK13517 290340008565 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340008566 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 290340008567 UGMP family protein; Validated; Region: PRK09604 290340008568 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290340008569 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 290340008570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008571 Coenzyme A binding pocket [chemical binding]; other site 290340008572 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290340008573 Glycoprotease family; Region: Peptidase_M22; pfam00814 290340008574 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 290340008575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290340008576 alanine racemase; Reviewed; Region: alr; PRK00053 290340008577 active site 290340008578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340008579 dimer interface [polypeptide binding]; other site 290340008580 substrate binding site [chemical binding]; other site 290340008581 catalytic residues [active] 290340008582 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 290340008583 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340008584 substrate binding site [chemical binding]; other site 290340008585 ATP binding site [chemical binding]; other site 290340008586 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290340008587 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 290340008588 NAD binding site [chemical binding]; other site 290340008589 sugar binding site [chemical binding]; other site 290340008590 divalent metal binding site [ion binding]; other site 290340008591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340008592 dimer interface [polypeptide binding]; other site 290340008593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340008594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340008595 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 290340008596 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290340008597 putative ADP-binding pocket [chemical binding]; other site 290340008598 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 290340008599 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 290340008600 Potassium binding sites [ion binding]; other site 290340008601 Cesium cation binding sites [ion binding]; other site 290340008602 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 290340008603 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 290340008604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340008605 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340008606 active site 290340008607 catalytic tetrad [active] 290340008608 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 290340008609 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 290340008610 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 290340008611 catalytic site [active] 290340008612 active site 290340008613 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290340008614 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 290340008615 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 290340008616 active site 290340008617 catalytic site [active] 290340008618 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290340008619 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290340008620 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290340008621 active site 290340008622 catalytic site [active] 290340008623 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 290340008624 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290340008625 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 290340008626 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290340008627 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290340008628 glutaminase active site [active] 290340008629 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290340008630 dimer interface [polypeptide binding]; other site 290340008631 active site 290340008632 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290340008633 dimer interface [polypeptide binding]; other site 290340008634 active site 290340008635 pantothenate kinase; Provisional; Region: PRK05439 290340008636 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 290340008637 ATP-binding site [chemical binding]; other site 290340008638 CoA-binding site [chemical binding]; other site 290340008639 Mg2+-binding site [ion binding]; other site 290340008640 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 290340008641 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 290340008642 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 290340008643 active site 290340008644 substrate binding site [chemical binding]; other site 290340008645 metal binding site [ion binding]; metal-binding site 290340008646 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 290340008647 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290340008648 23S rRNA interface [nucleotide binding]; other site 290340008649 L3 interface [polypeptide binding]; other site 290340008650 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 290340008651 TadE-like protein; Region: TadE; pfam07811 290340008652 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 290340008653 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 290340008654 AAA domain; Region: AAA_31; pfam13614 290340008655 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 290340008656 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 290340008657 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290340008658 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340008659 ATP binding site [chemical binding]; other site 290340008660 Walker A motif; other site 290340008661 hexamer interface [polypeptide binding]; other site 290340008662 Walker B motif; other site 290340008663 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290340008664 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290340008665 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 290340008666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290340008667 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290340008668 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290340008669 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 290340008670 dimerization interface 3.5A [polypeptide binding]; other site 290340008671 active site 290340008672 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 290340008673 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290340008674 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290340008675 alphaNTD homodimer interface [polypeptide binding]; other site 290340008676 alphaNTD - beta interaction site [polypeptide binding]; other site 290340008677 alphaNTD - beta' interaction site [polypeptide binding]; other site 290340008678 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 290340008679 30S ribosomal protein S11; Validated; Region: PRK05309 290340008680 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 290340008681 30S ribosomal protein S13; Region: bact_S13; TIGR03631 290340008682 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 290340008683 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290340008684 rRNA binding site [nucleotide binding]; other site 290340008685 predicted 30S ribosome binding site; other site 290340008686 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 290340008687 putative active site pocket [active] 290340008688 cleavage site 290340008689 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340008690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008691 dimer interface [polypeptide binding]; other site 290340008692 conserved gate region; other site 290340008693 putative PBP binding loops; other site 290340008694 ABC-ATPase subunit interface; other site 290340008695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008697 dimer interface [polypeptide binding]; other site 290340008698 conserved gate region; other site 290340008699 putative PBP binding loops; other site 290340008700 ABC-ATPase subunit interface; other site 290340008701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290340008702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340008703 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290340008704 active site 290340008705 adenylate kinase; Reviewed; Region: adk; PRK00279 290340008706 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340008707 AMP-binding site [chemical binding]; other site 290340008708 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340008709 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290340008710 SecY translocase; Region: SecY; pfam00344 290340008711 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 290340008712 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290340008713 23S rRNA binding site [nucleotide binding]; other site 290340008714 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290340008715 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290340008716 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290340008717 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290340008718 23S rRNA interface [nucleotide binding]; other site 290340008719 5S rRNA interface [nucleotide binding]; other site 290340008720 L27 interface [polypeptide binding]; other site 290340008721 L5 interface [polypeptide binding]; other site 290340008722 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290340008723 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290340008724 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290340008725 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 290340008726 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290340008727 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290340008728 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290340008729 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290340008730 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 290340008731 RNA binding site [nucleotide binding]; other site 290340008732 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 290340008733 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 290340008734 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290340008735 23S rRNA interface [nucleotide binding]; other site 290340008736 putative translocon interaction site; other site 290340008737 signal recognition particle (SRP54) interaction site; other site 290340008738 L23 interface [polypeptide binding]; other site 290340008739 trigger factor interaction site; other site 290340008740 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290340008741 23S rRNA interface [nucleotide binding]; other site 290340008742 5S rRNA interface [nucleotide binding]; other site 290340008743 putative antibiotic binding site [chemical binding]; other site 290340008744 L25 interface [polypeptide binding]; other site 290340008745 L27 interface [polypeptide binding]; other site 290340008746 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290340008747 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290340008748 G-X-X-G motif; other site 290340008749 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290340008750 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290340008751 putative translocon binding site; other site 290340008752 protein-rRNA interface [nucleotide binding]; other site 290340008753 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 290340008754 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290340008755 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290340008756 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290340008757 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 290340008758 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 290340008759 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 290340008760 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 290340008761 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290340008762 beta-galactosidase; Region: BGL; TIGR03356 290340008763 elongation factor Tu; Reviewed; Region: PRK00049 290340008764 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290340008765 G1 box; other site 290340008766 GEF interaction site [polypeptide binding]; other site 290340008767 GTP/Mg2+ binding site [chemical binding]; other site 290340008768 Switch I region; other site 290340008769 G2 box; other site 290340008770 G3 box; other site 290340008771 Switch II region; other site 290340008772 G4 box; other site 290340008773 G5 box; other site 290340008774 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290340008775 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290340008776 Antibiotic Binding Site [chemical binding]; other site 290340008777 elongation factor G; Reviewed; Region: PRK00007 290340008778 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290340008779 G1 box; other site 290340008780 putative GEF interaction site [polypeptide binding]; other site 290340008781 GTP/Mg2+ binding site [chemical binding]; other site 290340008782 Switch I region; other site 290340008783 G2 box; other site 290340008784 G3 box; other site 290340008785 Switch II region; other site 290340008786 G4 box; other site 290340008787 G5 box; other site 290340008788 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290340008789 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290340008790 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290340008791 30S ribosomal protein S7; Validated; Region: PRK05302 290340008792 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290340008793 S17 interaction site [polypeptide binding]; other site 290340008794 S8 interaction site; other site 290340008795 16S rRNA interaction site [nucleotide binding]; other site 290340008796 streptomycin interaction site [chemical binding]; other site 290340008797 23S rRNA interaction site [nucleotide binding]; other site 290340008798 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290340008799 DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387 290340008800 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290340008801 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 290340008802 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290340008803 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290340008804 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 290340008805 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290340008806 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290340008807 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290340008808 DNA binding site [nucleotide binding] 290340008809 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290340008810 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290340008811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290340008812 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 290340008813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290340008814 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 290340008815 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290340008816 RPB10 interaction site [polypeptide binding]; other site 290340008817 RPB1 interaction site [polypeptide binding]; other site 290340008818 RPB11 interaction site [polypeptide binding]; other site 290340008819 RPB3 interaction site [polypeptide binding]; other site 290340008820 RPB12 interaction site [polypeptide binding]; other site 290340008821 putative acyltransferase; Provisional; Region: PRK05790 290340008822 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340008823 dimer interface [polypeptide binding]; other site 290340008824 active site 290340008825 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 290340008826 putative deacylase active site [active] 290340008827 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290340008828 core dimer interface [polypeptide binding]; other site 290340008829 peripheral dimer interface [polypeptide binding]; other site 290340008830 L10 interface [polypeptide binding]; other site 290340008831 L11 interface [polypeptide binding]; other site 290340008832 putative EF-Tu interaction site [polypeptide binding]; other site 290340008833 putative EF-G interaction site [polypeptide binding]; other site 290340008834 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290340008835 23S rRNA interface [nucleotide binding]; other site 290340008836 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 290340008837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008838 Coenzyme A binding pocket [chemical binding]; other site 290340008839 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290340008840 mRNA/rRNA interface [nucleotide binding]; other site 290340008841 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290340008842 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290340008843 23S rRNA interface [nucleotide binding]; other site 290340008844 putative thiostrepton binding site; other site 290340008845 L7/L12 interface [polypeptide binding]; other site 290340008846 L25 interface [polypeptide binding]; other site 290340008847 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290340008848 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290340008849 putative homodimer interface [polypeptide binding]; other site 290340008850 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 290340008851 heterodimer interface [polypeptide binding]; other site 290340008852 homodimer interface [polypeptide binding]; other site 290340008853 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 290340008854 aspartate aminotransferase; Provisional; Region: PRK05764 290340008855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340008856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340008857 homodimer interface [polypeptide binding]; other site 290340008858 catalytic residue [active] 290340008859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340008860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 290340008861 UDP-glycosyltransferase family protein; Region: PLN02554 290340008862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340008863 DNA binding residues [nucleotide binding] 290340008864 dimerization interface [polypeptide binding]; other site 290340008865 PspC domain; Region: PspC; pfam04024 290340008866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340008867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340008868 ATP binding site [chemical binding]; other site 290340008869 Mg2+ binding site [ion binding]; other site 290340008870 G-X-G motif; other site 290340008871 PspC domain; Region: PspC; pfam04024 290340008872 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 290340008873 phosphofructokinase; Region: PFK_mixed; TIGR02483 290340008874 active site 290340008875 ADP/pyrophosphate binding site [chemical binding]; other site 290340008876 dimerization interface [polypeptide binding]; other site 290340008877 allosteric effector site; other site 290340008878 fructose-1,6-bisphosphate binding site; other site 290340008879 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340008880 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340008881 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340008882 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290340008883 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290340008884 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 290340008885 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 290340008886 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340008887 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290340008888 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 290340008889 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 290340008890 heme-binding site [chemical binding]; other site 290340008891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340008892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340008893 DNA binding site [nucleotide binding] 290340008894 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290340008895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008896 Coenzyme A binding pocket [chemical binding]; other site 290340008897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340008898 Coenzyme A binding pocket [chemical binding]; other site 290340008899 polyphosphate kinase; Provisional; Region: PRK05443 290340008900 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290340008901 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290340008902 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 290340008903 putative domain interface [polypeptide binding]; other site 290340008904 putative active site [active] 290340008905 catalytic site [active] 290340008906 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 290340008907 putative domain interface [polypeptide binding]; other site 290340008908 putative active site [active] 290340008909 catalytic site [active] 290340008910 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290340008911 active site 290340008912 Ap6A binding site [chemical binding]; other site 290340008913 nudix motif; other site 290340008914 metal binding site [ion binding]; metal-binding site 290340008915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340008916 catalytic core [active] 290340008917 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290340008918 thymidylate synthase; Reviewed; Region: thyA; PRK01827 290340008919 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 290340008920 dimerization interface [polypeptide binding]; other site 290340008921 active site 290340008922 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340008923 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 290340008924 folate binding site [chemical binding]; other site 290340008925 NADP+ binding site [chemical binding]; other site 290340008926 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290340008927 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 290340008928 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340008929 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340008930 putative active site [active] 290340008931 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290340008932 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 290340008933 FAD binding domain; Region: FAD_binding_4; pfam01565 290340008934 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290340008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340008936 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340008937 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 290340008938 active site 290340008939 catalytic site [active] 290340008940 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 290340008941 active site 290340008942 catalytic site [active] 290340008943 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 290340008944 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290340008945 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340008946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340008947 substrate binding pocket [chemical binding]; other site 290340008948 membrane-bound complex binding site; other site 290340008949 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340008950 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290340008951 Walker A/P-loop; other site 290340008952 ATP binding site [chemical binding]; other site 290340008953 Q-loop/lid; other site 290340008954 ABC transporter signature motif; other site 290340008955 Walker B; other site 290340008956 D-loop; other site 290340008957 H-loop/switch region; other site 290340008958 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340008959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008960 putative PBP binding loops; other site 290340008961 dimer interface [polypeptide binding]; other site 290340008962 ABC-ATPase subunit interface; other site 290340008963 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 290340008964 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290340008965 active site 290340008966 iron coordination sites [ion binding]; other site 290340008967 substrate binding pocket [chemical binding]; other site 290340008968 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290340008969 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290340008970 active site 290340008971 catalytic site [active] 290340008972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340008973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008974 dimer interface [polypeptide binding]; other site 290340008975 conserved gate region; other site 290340008976 putative PBP binding loops; other site 290340008977 ABC-ATPase subunit interface; other site 290340008978 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340008979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340008980 dimer interface [polypeptide binding]; other site 290340008981 conserved gate region; other site 290340008982 putative PBP binding loops; other site 290340008983 ABC-ATPase subunit interface; other site 290340008984 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340008985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340008986 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340008987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340008988 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 290340008989 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290340008990 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290340008991 NAD(P) binding site [chemical binding]; other site 290340008992 putative active site [active] 290340008993 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340008994 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340008995 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 290340008996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290340008997 ATP binding site [chemical binding]; other site 290340008998 Mg++ binding site [ion binding]; other site 290340008999 motif III; other site 290340009000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340009001 nucleotide binding region [chemical binding]; other site 290340009002 ATP-binding site [chemical binding]; other site 290340009003 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 290340009004 putative RNA binding site [nucleotide binding]; other site 290340009005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 290340009006 MOSC domain; Region: MOSC; pfam03473 290340009007 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290340009008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009009 active site 290340009010 phosphorylation site [posttranslational modification] 290340009011 intermolecular recognition site; other site 290340009012 dimerization interface [polypeptide binding]; other site 290340009013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340009014 DNA binding site [nucleotide binding] 290340009015 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 290340009016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340009017 dimer interface [polypeptide binding]; other site 290340009018 phosphorylation site [posttranslational modification] 290340009019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009020 ATP binding site [chemical binding]; other site 290340009021 Mg2+ binding site [ion binding]; other site 290340009022 G-X-G motif; other site 290340009023 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290340009024 Amino acid permease; Region: AA_permease_2; pfam13520 290340009025 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340009026 acyl-coenzyme A oxidase; Region: PLN02526 290340009027 active site 290340009028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340009029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340009030 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340009031 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009034 dimer interface [polypeptide binding]; other site 290340009035 conserved gate region; other site 290340009036 putative PBP binding loops; other site 290340009037 ABC-ATPase subunit interface; other site 290340009038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009040 dimer interface [polypeptide binding]; other site 290340009041 conserved gate region; other site 290340009042 putative PBP binding loops; other site 290340009043 ABC-ATPase subunit interface; other site 290340009044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340009046 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340009047 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290340009048 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 290340009049 Phosphoesterase family; Region: Phosphoesterase; pfam04185 290340009050 Domain of unknown function (DUF756); Region: DUF756; pfam05506 290340009051 Domain of unknown function (DUF756); Region: DUF756; pfam05506 290340009052 cystathionine gamma-synthase; Provisional; Region: PRK07811 290340009053 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340009054 homodimer interface [polypeptide binding]; other site 290340009055 substrate-cofactor binding pocket; other site 290340009056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340009057 catalytic residue [active] 290340009058 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 290340009059 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340009060 dimer interface [polypeptide binding]; other site 290340009061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340009062 catalytic residue [active] 290340009063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290340009064 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340009065 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340009066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290340009067 minor groove reading motif; other site 290340009068 helix-hairpin-helix signature motif; other site 290340009069 substrate binding pocket [chemical binding]; other site 290340009070 active site 290340009071 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340009072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340009073 Walker A/P-loop; other site 290340009074 ATP binding site [chemical binding]; other site 290340009075 Q-loop/lid; other site 290340009076 ABC transporter signature motif; other site 290340009077 Walker B; other site 290340009078 D-loop; other site 290340009079 H-loop/switch region; other site 290340009080 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290340009081 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290340009082 AMP-binding domain protein; Validated; Region: PRK08315 290340009083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340009084 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 290340009085 acyl-activating enzyme (AAE) consensus motif; other site 290340009086 putative AMP binding site [chemical binding]; other site 290340009087 putative active site [active] 290340009088 putative CoA binding site [chemical binding]; other site 290340009089 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290340009090 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340009091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340009092 catalytic residues [active] 290340009093 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340009094 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290340009095 Walker A/P-loop; other site 290340009096 ATP binding site [chemical binding]; other site 290340009097 Q-loop/lid; other site 290340009098 ABC transporter signature motif; other site 290340009099 Walker B; other site 290340009100 D-loop; other site 290340009101 H-loop/switch region; other site 290340009102 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340009103 active site 290340009104 Ion channel; Region: Ion_trans_2; pfam07885 290340009105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 290340009106 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 290340009107 heat shock protein HtpX; Provisional; Region: PRK03072 290340009108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009109 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340009110 putative substrate translocation pore; other site 290340009111 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290340009112 metal binding site 2 [ion binding]; metal-binding site 290340009113 putative DNA binding helix; other site 290340009114 metal binding site 1 [ion binding]; metal-binding site 290340009115 structural Zn2+ binding site [ion binding]; other site 290340009116 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 290340009117 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 290340009118 tetramer interface [polypeptide binding]; other site 290340009119 heme binding pocket [chemical binding]; other site 290340009120 NADPH binding site [chemical binding]; other site 290340009121 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 290340009122 amino acid transporter; Region: 2A0306; TIGR00909 290340009123 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290340009124 Protein of unknown function (DUF779); Region: DUF779; pfam05610 290340009125 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340009126 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 290340009127 NAD binding site [chemical binding]; other site 290340009128 substrate binding site [chemical binding]; other site 290340009129 catalytic Zn binding site [ion binding]; other site 290340009130 tetramer interface [polypeptide binding]; other site 290340009131 structural Zn binding site [ion binding]; other site 290340009132 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340009133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340009134 NAD(P) binding site [chemical binding]; other site 290340009135 catalytic residues [active] 290340009136 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 290340009137 ferredoxin-NADP+ reductase; Region: PLN02852 290340009138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340009139 Predicted permeases [General function prediction only]; Region: RarD; COG2962 290340009140 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 290340009141 substrate binding site [chemical binding]; other site 290340009142 catalytic residues [active] 290340009143 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 290340009144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340009145 inhibitor-cofactor binding pocket; inhibition site 290340009146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340009147 catalytic residue [active] 290340009148 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290340009149 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340009150 tetrameric interface [polypeptide binding]; other site 290340009151 NAD binding site [chemical binding]; other site 290340009152 catalytic residues [active] 290340009153 substrate binding site [chemical binding]; other site 290340009154 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340009155 Class I aldolases; Region: Aldolase_Class_I; cl17187 290340009156 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 290340009157 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340009158 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340009159 transcriptional regulator NanR; Provisional; Region: PRK03837 290340009160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340009161 DNA-binding site [nucleotide binding]; DNA binding site 290340009162 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290340009163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340009164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340009165 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340009166 active site residue [active] 290340009167 ferredoxin-NADP+ reductase; Region: PLN02852 290340009168 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290340009169 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290340009170 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290340009171 active site 290340009172 SAM binding site [chemical binding]; other site 290340009173 homodimer interface [polypeptide binding]; other site 290340009174 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290340009175 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290340009176 active site 290340009177 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290340009178 glutaminase; Provisional; Region: PRK00971 290340009179 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290340009180 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 290340009181 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340009182 RibD C-terminal domain; Region: RibD_C; cl17279 290340009183 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290340009184 lipoprotein LpqB; Provisional; Region: PRK13616 290340009185 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340009186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009187 dimer interface [polypeptide binding]; other site 290340009188 conserved gate region; other site 290340009189 putative PBP binding loops; other site 290340009190 ABC-ATPase subunit interface; other site 290340009191 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340009192 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290340009193 Walker A/P-loop; other site 290340009194 ATP binding site [chemical binding]; other site 290340009195 Q-loop/lid; other site 290340009196 ABC transporter signature motif; other site 290340009197 Walker B; other site 290340009198 D-loop; other site 290340009199 H-loop/switch region; other site 290340009200 NMT1-like family; Region: NMT1_2; pfam13379 290340009201 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 290340009202 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 290340009203 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 290340009204 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 290340009205 CysD dimerization site [polypeptide binding]; other site 290340009206 G1 box; other site 290340009207 putative GEF interaction site [polypeptide binding]; other site 290340009208 GTP/Mg2+ binding site [chemical binding]; other site 290340009209 Switch I region; other site 290340009210 G2 box; other site 290340009211 G3 box; other site 290340009212 Switch II region; other site 290340009213 G4 box; other site 290340009214 G5 box; other site 290340009215 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 290340009216 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 290340009217 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 290340009218 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290340009219 Active Sites [active] 290340009220 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 290340009221 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290340009222 Active Sites [active] 290340009223 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 290340009224 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 290340009225 putative active site [active] 290340009226 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 290340009227 putative active site [active] 290340009228 Predicted membrane protein [Function unknown]; Region: COG2860 290340009229 UPF0126 domain; Region: UPF0126; pfam03458 290340009230 UPF0126 domain; Region: UPF0126; pfam03458 290340009231 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340009232 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340009233 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290340009234 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290340009235 substrate binding pocket [chemical binding]; other site 290340009236 chain length determination region; other site 290340009237 substrate-Mg2+ binding site; other site 290340009238 catalytic residues [active] 290340009239 aspartate-rich region 1; other site 290340009240 active site lid residues [active] 290340009241 aspartate-rich region 2; other site 290340009242 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290340009243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340009244 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 290340009245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340009246 S-adenosylmethionine binding site [chemical binding]; other site 290340009247 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 290340009248 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290340009249 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340009250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340009251 substrate binding pocket [chemical binding]; other site 290340009252 membrane-bound complex binding site; other site 290340009253 hinge residues; other site 290340009254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009255 dimer interface [polypeptide binding]; other site 290340009256 conserved gate region; other site 290340009257 putative PBP binding loops; other site 290340009258 ABC-ATPase subunit interface; other site 290340009259 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340009260 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340009261 Walker A/P-loop; other site 290340009262 ATP binding site [chemical binding]; other site 290340009263 Q-loop/lid; other site 290340009264 ABC transporter signature motif; other site 290340009265 Walker B; other site 290340009266 D-loop; other site 290340009267 H-loop/switch region; other site 290340009268 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290340009269 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290340009270 dimer interface [polypeptide binding]; other site 290340009271 tetramer interface [polypeptide binding]; other site 290340009272 PYR/PP interface [polypeptide binding]; other site 290340009273 TPP binding site [chemical binding]; other site 290340009274 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290340009275 TPP-binding site; other site 290340009276 SOUL heme-binding protein; Region: SOUL; pfam04832 290340009277 HTH-like domain; Region: HTH_21; pfam13276 290340009278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009279 Integrase core domain; Region: rve; pfam00665 290340009280 Integrase core domain; Region: rve_3; pfam13683 290340009281 Transposase; Region: HTH_Tnp_1; pfam01527 290340009282 Transposase; Region: HTH_Tnp_1; pfam01527 290340009283 HTH-like domain; Region: HTH_21; pfam13276 290340009284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009285 Integrase core domain; Region: rve; pfam00665 290340009286 Integrase core domain; Region: rve_3; pfam13683 290340009287 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 290340009288 O-succinylbenzoate synthase; Provisional; Region: PRK02901 290340009289 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290340009290 active site 290340009291 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 290340009292 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009294 DNA binding site [nucleotide binding] 290340009295 domain linker motif; other site 290340009296 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290340009297 putative dimerization interface [polypeptide binding]; other site 290340009298 putative ligand binding site [chemical binding]; other site 290340009299 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 290340009300 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290340009301 substrate binding [chemical binding]; other site 290340009302 active site 290340009303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009305 dimer interface [polypeptide binding]; other site 290340009306 conserved gate region; other site 290340009307 putative PBP binding loops; other site 290340009308 ABC-ATPase subunit interface; other site 290340009309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009310 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290340009311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009312 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340009313 PAP2 superfamily; Region: PAP2; pfam01569 290340009314 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290340009315 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340009316 active site 290340009317 catalytic triad [active] 290340009318 S-layer homology domain; Region: SLH; pfam00395 290340009319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340009320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009321 putative substrate translocation pore; other site 290340009322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290340009323 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 290340009324 S-layer homology domain; Region: SLH; pfam00395 290340009325 S-layer homology domain; Region: SLH; pfam00395 290340009326 S-layer homology domain; Region: SLH; pfam00395 290340009327 Putative Ig domain; Region: He_PIG; pfam05345 290340009328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290340009329 binding surface 290340009330 TPR motif; other site 290340009331 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340009332 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340009333 S-layer homology domain; Region: SLH; pfam00395 290340009334 S-layer homology domain; Region: SLH; pfam00395 290340009335 S-layer homology domain; Region: SLH; pfam00395 290340009336 Cation efflux family; Region: Cation_efflux; pfam01545 290340009337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 290340009338 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340009339 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340009340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340009341 Transporter associated domain; Region: CorC_HlyC; smart01091 290340009342 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340009343 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340009344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340009345 S-layer homology domain; Region: SLH; pfam00395 290340009346 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340009348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009349 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009350 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340009351 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009352 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009353 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340009354 active site 290340009355 catalytic triad [active] 290340009356 S-layer homology domain; Region: SLH; pfam00395 290340009357 S-layer homology domain; Region: SLH; pfam00395 290340009358 S-layer homology domain; Region: SLH; pfam00395 290340009359 S-layer homology domain; Region: SLH; pfam00395 290340009360 S-layer homology domain; Region: SLH; pfam00395 290340009361 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009362 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340009363 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009364 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340009365 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290340009366 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009367 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009368 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290340009369 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 290340009370 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 290340009371 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 290340009372 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290340009373 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290340009374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340009375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340009376 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340009377 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290340009378 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 290340009379 HTH-like domain; Region: HTH_21; pfam13276 290340009380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009381 Integrase core domain; Region: rve; pfam00665 290340009382 Integrase core domain; Region: rve_3; pfam13683 290340009383 Transposase; Region: HTH_Tnp_1; pfam01527 290340009384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340009385 E3 interaction surface; other site 290340009386 lipoyl attachment site [posttranslational modification]; other site 290340009387 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340009388 e3 binding domain; Region: E3_binding; pfam02817 290340009389 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290340009390 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340009391 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340009392 alpha subunit interface [polypeptide binding]; other site 290340009393 TPP binding site [chemical binding]; other site 290340009394 heterodimer interface [polypeptide binding]; other site 290340009395 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340009396 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290340009397 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340009398 AsnC family; Region: AsnC_trans_reg; pfam01037 290340009399 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290340009400 putative active site [active] 290340009401 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290340009402 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290340009403 substrate binding site; other site 290340009404 tetramer interface; other site 290340009405 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290340009406 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290340009407 NAD binding site [chemical binding]; other site 290340009408 substrate binding site [chemical binding]; other site 290340009409 homodimer interface [polypeptide binding]; other site 290340009410 active site 290340009411 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 290340009412 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290340009413 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 290340009414 NADP binding site [chemical binding]; other site 290340009415 active site 290340009416 putative substrate binding site [chemical binding]; other site 290340009417 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290340009418 Chain length determinant protein; Region: Wzz; pfam02706 290340009419 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290340009420 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340009421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340009422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009424 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340009425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340009426 active site 290340009427 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290340009428 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340009429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340009430 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 290340009431 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 290340009432 putative ADP-binding pocket [chemical binding]; other site 290340009433 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340009434 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290340009435 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340009436 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290340009437 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340009438 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290340009439 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 290340009440 HTH-like domain; Region: HTH_21; pfam13276 290340009441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009442 Integrase core domain; Region: rve; pfam00665 290340009443 Integrase core domain; Region: rve_3; pfam13683 290340009444 Transposase; Region: HTH_Tnp_1; pfam01527 290340009445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340009446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340009447 Helix-turn-helix domain; Region: HTH_17; pfam12728 290340009448 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 290340009449 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290340009450 putative di-iron ligands [ion binding]; other site 290340009451 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290340009452 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290340009453 FAD binding pocket [chemical binding]; other site 290340009454 FAD binding motif [chemical binding]; other site 290340009455 phosphate binding motif [ion binding]; other site 290340009456 beta-alpha-beta structure motif; other site 290340009457 NAD binding pocket [chemical binding]; other site 290340009458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340009459 catalytic loop [active] 290340009460 iron binding site [ion binding]; other site 290340009461 LabA_like proteins; Region: LabA_like; cd06167 290340009462 putative metal binding site [ion binding]; other site 290340009463 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290340009464 phosphopeptide binding site; other site 290340009465 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 290340009466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290340009467 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 290340009468 active site 290340009469 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 290340009470 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290340009471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340009472 Coenzyme A binding pocket [chemical binding]; other site 290340009473 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 290340009474 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 290340009475 Family description; Region: VCBS; pfam13517 290340009476 FG-GAP repeat; Region: FG-GAP; pfam01839 290340009477 Family description; Region: VCBS; pfam13517 290340009478 MarR family; Region: MarR_2; cl17246 290340009479 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340009480 hypothetical protein; Validated; Region: PRK00029 290340009481 Uncharacterized conserved protein [Function unknown]; Region: COG0397 290340009482 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290340009483 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290340009484 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290340009485 active site 290340009486 catalytic triad [active] 290340009487 S-layer homology domain; Region: SLH; pfam00395 290340009488 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340009489 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 290340009490 S-layer homology domain; Region: SLH; pfam00395 290340009491 S-layer homology domain; Region: SLH; pfam00395 290340009492 S-layer homology domain; Region: SLH; pfam00395 290340009493 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 290340009494 S-layer homology domain; Region: SLH; pfam00395 290340009495 S-layer homology domain; Region: SLH; pfam00395 290340009496 Excalibur calcium-binding domain; Region: Excalibur; smart00894 290340009497 S-layer homology domain; Region: SLH; pfam00395 290340009498 S-layer homology domain; Region: SLH; pfam00395 290340009499 S-layer homology domain; Region: SLH; pfam00395 290340009500 S-layer homology domain; Region: SLH; pfam00395 290340009501 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 290340009502 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 290340009503 active site 290340009504 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 290340009505 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290340009506 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 290340009507 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290340009508 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 290340009509 enoyl-CoA hydratase; Provisional; Region: PRK08140 290340009510 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009511 substrate binding site [chemical binding]; other site 290340009512 oxyanion hole (OAH) forming residues; other site 290340009513 trimer interface [polypeptide binding]; other site 290340009514 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 290340009515 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 290340009516 FAD binding pocket [chemical binding]; other site 290340009517 FAD binding motif [chemical binding]; other site 290340009518 phosphate binding motif [ion binding]; other site 290340009519 beta-alpha-beta structure motif; other site 290340009520 NAD(p) ribose binding residues [chemical binding]; other site 290340009521 NAD binding pocket [chemical binding]; other site 290340009522 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 290340009523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340009524 catalytic loop [active] 290340009525 iron binding site [ion binding]; other site 290340009526 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 290340009527 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 290340009528 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 290340009529 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 290340009530 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 290340009531 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 290340009532 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340009533 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340009534 active site 290340009535 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340009536 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340009537 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 290340009538 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 290340009539 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340009540 Catalytic site [active] 290340009541 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 290340009542 VanZ like family; Region: VanZ; pfam04892 290340009543 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290340009544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290340009545 putative active site [active] 290340009546 heme pocket [chemical binding]; other site 290340009547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340009548 dimer interface [polypeptide binding]; other site 290340009549 phosphorylation site [posttranslational modification] 290340009550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009551 ATP binding site [chemical binding]; other site 290340009552 Mg2+ binding site [ion binding]; other site 290340009553 G-X-G motif; other site 290340009554 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009556 active site 290340009557 phosphorylation site [posttranslational modification] 290340009558 intermolecular recognition site; other site 290340009559 dimerization interface [polypeptide binding]; other site 290340009560 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290340009561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009562 active site 290340009563 phosphorylation site [posttranslational modification] 290340009564 intermolecular recognition site; other site 290340009565 dimerization interface [polypeptide binding]; other site 290340009566 Response regulator receiver domain; Region: Response_reg; pfam00072 290340009567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340009568 active site 290340009569 phosphorylation site [posttranslational modification] 290340009570 intermolecular recognition site; other site 290340009571 dimerization interface [polypeptide binding]; other site 290340009572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340009573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340009574 metal binding site [ion binding]; metal-binding site 290340009575 active site 290340009576 I-site; other site 290340009577 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 290340009578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340009579 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290340009580 Methyltransferase domain; Region: Methyltransf_18; pfam12847 290340009581 S-adenosylmethionine binding site [chemical binding]; other site 290340009582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340009583 dimer interface [polypeptide binding]; other site 290340009584 phosphorylation site [posttranslational modification] 290340009585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340009586 ATP binding site [chemical binding]; other site 290340009587 Mg2+ binding site [ion binding]; other site 290340009588 G-X-G motif; other site 290340009589 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340009590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340009591 metal binding site [ion binding]; metal-binding site 290340009592 active site 290340009593 I-site; other site 290340009594 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340009595 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340009596 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340009597 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290340009598 CoenzymeA binding site [chemical binding]; other site 290340009599 subunit interaction site [polypeptide binding]; other site 290340009600 PHB binding site; other site 290340009601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340009602 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 290340009603 acyl-activating enzyme (AAE) consensus motif; other site 290340009604 AMP binding site [chemical binding]; other site 290340009605 active site 290340009606 CoA binding site [chemical binding]; other site 290340009607 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 290340009608 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 290340009609 substrate binding site [chemical binding]; other site 290340009610 dimer interface [polypeptide binding]; other site 290340009611 NADP binding site [chemical binding]; other site 290340009612 catalytic residues [active] 290340009613 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340009614 active site 2 [active] 290340009615 active site 1 [active] 290340009616 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340009617 S-layer homology domain; Region: SLH; pfam00395 290340009618 S-layer homology domain; Region: SLH; pfam00395 290340009619 S-layer homology domain; Region: SLH; pfam00395 290340009620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290340009621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290340009622 active site 290340009623 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 290340009624 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340009625 active site 290340009626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009628 DNA binding site [nucleotide binding] 290340009629 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290340009630 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340009631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009632 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340009633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009634 ABC-ATPase subunit interface; other site 290340009635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009637 dimer interface [polypeptide binding]; other site 290340009638 conserved gate region; other site 290340009639 putative PBP binding loops; other site 290340009640 ABC-ATPase subunit interface; other site 290340009641 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 290340009642 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009643 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340009644 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340009645 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 290340009646 active site 290340009647 catalytic triad [active] 290340009648 oxyanion hole [active] 290340009649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340009650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340009651 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 290340009652 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290340009653 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290340009654 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 290340009655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009656 substrate binding site [chemical binding]; other site 290340009657 oxyanion hole (OAH) forming residues; other site 290340009658 trimer interface [polypeptide binding]; other site 290340009659 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 290340009660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340009661 dimer interface [polypeptide binding]; other site 290340009662 active site 290340009663 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290340009664 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290340009665 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290340009666 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290340009667 hydrophobic ligand binding site; other site 290340009668 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290340009669 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340009670 iron-sulfur cluster [ion binding]; other site 290340009671 [2Fe-2S] cluster binding site [ion binding]; other site 290340009672 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290340009673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340009674 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290340009675 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290340009676 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340009677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340009678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340009679 D-loop; other site 290340009680 H-loop/switch region; other site 290340009681 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340009682 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 290340009683 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340009684 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290340009685 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290340009686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340009687 ABC-ATPase subunit interface; other site 290340009688 dimer interface [polypeptide binding]; other site 290340009689 putative PBP binding regions; other site 290340009690 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290340009691 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290340009692 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 290340009693 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290340009694 metal binding site [ion binding]; metal-binding site 290340009695 CAAX protease self-immunity; Region: Abi; pfam02517 290340009696 active site 290340009697 metal binding site [ion binding]; metal-binding site 290340009698 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 290340009699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340009700 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290340009701 substrate binding site [chemical binding]; other site 290340009702 oxyanion hole (OAH) forming residues; other site 290340009703 trimer interface [polypeptide binding]; other site 290340009704 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 290340009705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340009706 acyl-activating enzyme (AAE) consensus motif; other site 290340009707 AMP binding site [chemical binding]; other site 290340009708 active site 290340009709 CoA binding site [chemical binding]; other site 290340009710 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 290340009711 UbiA prenyltransferase family; Region: UbiA; pfam01040 290340009712 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 290340009713 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340009714 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290340009715 Dynamin family; Region: Dynamin_N; pfam00350 290340009716 G1 box; other site 290340009717 GTP/Mg2+ binding site [chemical binding]; other site 290340009718 G2 box; other site 290340009719 Switch I region; other site 290340009720 G3 box; other site 290340009721 Switch II region; other site 290340009722 G4 box; other site 290340009723 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290340009724 Dynamin family; Region: Dynamin_N; pfam00350 290340009725 G1 box; other site 290340009726 GTP/Mg2+ binding site [chemical binding]; other site 290340009727 G2 box; other site 290340009728 Switch I region; other site 290340009729 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290340009730 G3 box; other site 290340009731 Switch II region; other site 290340009732 GTP/Mg2+ binding site [chemical binding]; other site 290340009733 G4 box; other site 290340009734 G5 box; other site 290340009735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340009736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340009737 DNA binding residues [nucleotide binding] 290340009738 dimerization interface [polypeptide binding]; other site 290340009739 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 290340009740 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 290340009741 nucleotide binding site [chemical binding]; other site 290340009742 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290340009743 SBD interface [polypeptide binding]; other site 290340009744 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290340009745 ResB-like family; Region: ResB; pfam05140 290340009746 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340009747 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290340009748 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340009749 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340009750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340009751 catalytic residues [active] 290340009752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340009753 catalytic core [active] 290340009754 Uncharacterized conserved protein [Function unknown]; Region: COG2353 290340009755 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 290340009756 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 290340009757 CoA binding domain; Region: CoA_binding; pfam02629 290340009758 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 290340009759 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290340009760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340009761 motif II; other site 290340009762 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340009763 Transposase; Region: HTH_Tnp_1; pfam01527 290340009764 HTH-like domain; Region: HTH_21; pfam13276 290340009765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340009766 Integrase core domain; Region: rve; pfam00665 290340009767 Integrase core domain; Region: rve_3; pfam13683 290340009768 DNA binding domain, excisionase family; Region: excise; TIGR01764 290340009769 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 290340009770 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290340009771 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 290340009772 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340009774 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340009775 enterobactin exporter EntS; Provisional; Region: PRK10489 290340009776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340009777 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009779 dimer interface [polypeptide binding]; other site 290340009780 conserved gate region; other site 290340009781 putative PBP binding loops; other site 290340009782 ABC-ATPase subunit interface; other site 290340009783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340009784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009785 dimer interface [polypeptide binding]; other site 290340009786 putative PBP binding loops; other site 290340009787 ABC-ATPase subunit interface; other site 290340009788 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009789 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009790 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340009791 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 290340009792 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340009793 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340009794 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009798 dimer interface [polypeptide binding]; other site 290340009799 conserved gate region; other site 290340009800 putative PBP binding loops; other site 290340009801 ABC-ATPase subunit interface; other site 290340009802 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009804 dimer interface [polypeptide binding]; other site 290340009805 conserved gate region; other site 290340009806 putative PBP binding loops; other site 290340009807 ABC-ATPase subunit interface; other site 290340009808 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009809 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340009810 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340009811 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290340009812 active site 290340009813 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 290340009814 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290340009815 dimer interface [polypeptide binding]; other site 290340009816 NADP binding site [chemical binding]; other site 290340009817 catalytic residues [active] 290340009818 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340009819 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290340009820 active site pocket [active] 290340009821 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 290340009822 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340009823 catalytic residue [active] 290340009824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340009825 extended (e) SDRs; Region: SDR_e; cd08946 290340009826 NAD(P) binding site [chemical binding]; other site 290340009827 active site 290340009828 substrate binding site [chemical binding]; other site 290340009829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340009831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340009832 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009834 DNA binding site [nucleotide binding] 290340009835 domain linker motif; other site 290340009836 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340009837 dimerization interface [polypeptide binding]; other site 290340009838 ligand binding site [chemical binding]; other site 290340009839 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340009840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340009841 DNA-binding site [nucleotide binding]; DNA binding site 290340009842 FCD domain; Region: FCD; pfam07729 290340009843 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 290340009844 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290340009845 phosphate binding site [ion binding]; other site 290340009846 glutamate dehydrogenase; Provisional; Region: PRK09414 290340009847 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290340009848 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 290340009849 NAD(P) binding site [chemical binding]; other site 290340009850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340009851 dimerization interface [polypeptide binding]; other site 290340009852 putative DNA binding site [nucleotide binding]; other site 290340009853 putative Zn2+ binding site [ion binding]; other site 290340009854 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 290340009855 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 290340009856 active site 290340009857 Zn binding site [ion binding]; other site 290340009858 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290340009859 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 290340009860 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290340009861 TrkA-N domain; Region: TrkA_N; pfam02254 290340009862 TrkA-C domain; Region: TrkA_C; pfam02080 290340009863 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290340009864 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290340009865 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340009866 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340009867 AP (apurinic/apyrimidinic) site pocket; other site 290340009868 Metal-binding active site; metal-binding site 290340009869 exopolyphosphatase; Region: exo_poly_only; TIGR03706 290340009870 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290340009871 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 290340009872 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290340009873 active site 290340009874 interdomain interaction site; other site 290340009875 putative metal-binding site [ion binding]; other site 290340009876 nucleotide binding site [chemical binding]; other site 290340009877 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290340009878 domain I; other site 290340009879 DNA binding groove [nucleotide binding] 290340009880 phosphate binding site [ion binding]; other site 290340009881 domain II; other site 290340009882 domain III; other site 290340009883 nucleotide binding site [chemical binding]; other site 290340009884 catalytic site [active] 290340009885 domain IV; other site 290340009886 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009887 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009888 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290340009889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340009890 dimerization interface [polypeptide binding]; other site 290340009891 putative DNA binding site [nucleotide binding]; other site 290340009892 putative Zn2+ binding site [ion binding]; other site 290340009893 putative methyltransferase; Provisional; Region: PRK14967 290340009894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340009895 S-adenosylmethionine binding site [chemical binding]; other site 290340009896 Src homology 2 (SH2) domain; Region: SH2; cl15255 290340009897 phosphotyrosine binding pocket [polypeptide binding]; other site 290340009898 hydrophobic binding pocket [polypeptide binding]; other site 290340009899 hypothetical protein; Validated; Region: PRK01415 290340009900 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 290340009901 active site residue [active] 290340009902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340009903 Coenzyme A binding pocket [chemical binding]; other site 290340009904 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 290340009905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340009906 ATP binding site [chemical binding]; other site 290340009907 putative Mg++ binding site [ion binding]; other site 290340009908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340009909 nucleotide binding region [chemical binding]; other site 290340009910 ATP-binding site [chemical binding]; other site 290340009911 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 290340009912 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 290340009913 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290340009914 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 290340009915 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 290340009916 Walker A motif; other site 290340009917 ATP binding site [chemical binding]; other site 290340009918 Walker B motif; other site 290340009919 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 290340009920 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 290340009921 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 290340009922 active site 290340009923 DNA binding site [nucleotide binding] 290340009924 catalytic site [active] 290340009925 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 290340009926 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 290340009927 putative active site [active] 290340009928 putative CoA binding site [chemical binding]; other site 290340009929 nudix motif; other site 290340009930 metal binding site [ion binding]; metal-binding site 290340009931 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 290340009932 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290340009933 minor groove reading motif; other site 290340009934 helix-hairpin-helix signature motif; other site 290340009935 substrate binding pocket [chemical binding]; other site 290340009936 active site 290340009937 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 290340009938 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340009939 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290340009940 active site 290340009941 CoA binding site [chemical binding]; other site 290340009942 acyl-activating enzyme (AAE) consensus motif; other site 290340009943 AMP binding site [chemical binding]; other site 290340009944 acetate binding site [chemical binding]; other site 290340009945 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340009946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340009947 DNA-binding site [nucleotide binding]; DNA binding site 290340009948 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340009949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340009950 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290340009951 Walker A/P-loop; other site 290340009952 ATP binding site [chemical binding]; other site 290340009953 Q-loop/lid; other site 290340009954 ABC transporter signature motif; other site 290340009955 Walker B; other site 290340009956 D-loop; other site 290340009957 H-loop/switch region; other site 290340009958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340009959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340009960 DNA binding site [nucleotide binding] 290340009961 domain linker motif; other site 290340009962 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340009963 dimerization interface [polypeptide binding]; other site 290340009964 ligand binding site [chemical binding]; other site 290340009965 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340009966 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340009967 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290340009968 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340009969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340009970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340009971 dimer interface [polypeptide binding]; other site 290340009972 conserved gate region; other site 290340009973 putative PBP binding loops; other site 290340009974 ABC-ATPase subunit interface; other site 290340009975 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340009976 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340009977 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 290340009978 Melibiase; Region: Melibiase; pfam02065 290340009979 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290340009980 Dehydroquinase class II; Region: DHquinase_II; pfam01220 290340009981 trimer interface [polypeptide binding]; other site 290340009982 active site 290340009983 dimer interface [polypeptide binding]; other site 290340009984 Colicin V production protein; Region: Colicin_V; pfam02674 290340009985 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 290340009986 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290340009987 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290340009988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290340009989 ligand binding site [chemical binding]; other site 290340009990 flexible hinge region; other site 290340009991 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290340009992 putative switch regulator; other site 290340009993 non-specific DNA interactions [nucleotide binding]; other site 290340009994 DNA binding site [nucleotide binding] 290340009995 sequence specific DNA binding site [nucleotide binding]; other site 290340009996 putative cAMP binding site [chemical binding]; other site 290340009997 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290340009998 homotrimer interaction site [polypeptide binding]; other site 290340009999 putative active site [active] 290340010000 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 290340010001 Transglycosylase; Region: Transgly; pfam00912 290340010002 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290340010003 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290340010004 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 290340010005 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290340010006 putative active site [active] 290340010007 putative metal binding site [ion binding]; other site 290340010008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340010009 MarR family; Region: MarR_2; pfam12802 290340010010 MMPL family; Region: MMPL; pfam03176 290340010011 MMPL family; Region: MMPL; pfam03176 290340010012 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290340010013 active site 290340010014 hypothetical protein; Provisional; Region: PRK06184 290340010015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290340010016 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 290340010017 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 290340010018 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 290340010019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340010021 active site 290340010022 catalytic tetrad [active] 290340010023 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340010024 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340010025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010026 Walker A/P-loop; other site 290340010027 ATP binding site [chemical binding]; other site 290340010028 Q-loop/lid; other site 290340010029 ABC transporter signature motif; other site 290340010030 Walker B; other site 290340010031 D-loop; other site 290340010032 H-loop/switch region; other site 290340010033 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340010034 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340010035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010036 Walker A/P-loop; other site 290340010037 ATP binding site [chemical binding]; other site 290340010038 Q-loop/lid; other site 290340010039 ABC transporter signature motif; other site 290340010040 Walker B; other site 290340010041 D-loop; other site 290340010042 H-loop/switch region; other site 290340010043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340010044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340010045 non-specific DNA binding site [nucleotide binding]; other site 290340010046 salt bridge; other site 290340010047 sequence-specific DNA binding site [nucleotide binding]; other site 290340010048 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 290340010049 ATP binding site [chemical binding]; other site 290340010050 active site 290340010051 substrate binding site [chemical binding]; other site 290340010052 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290340010053 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290340010054 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 290340010055 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290340010056 L-asparaginase II; Region: Asparaginase_II; pfam06089 290340010057 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290340010058 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290340010059 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290340010060 classical (c) SDRs; Region: SDR_c; cd05233 290340010061 NAD(P) binding site [chemical binding]; other site 290340010062 active site 290340010063 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290340010064 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 290340010065 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290340010066 Na binding site [ion binding]; other site 290340010067 putative substrate binding site [chemical binding]; other site 290340010068 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290340010069 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290340010070 dimer interface [polypeptide binding]; other site 290340010071 TPP-binding site [chemical binding]; other site 290340010072 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 290340010073 metal-binding site 290340010074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010075 Coenzyme A binding pocket [chemical binding]; other site 290340010076 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 290340010077 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290340010078 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 290340010079 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 290340010080 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290340010081 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 290340010082 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 290340010083 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290340010084 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290340010085 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340010086 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290340010087 nucleoside/Zn binding site; other site 290340010088 dimer interface [polypeptide binding]; other site 290340010089 catalytic motif [active] 290340010090 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340010091 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340010092 active site 290340010093 putative substrate binding pocket [chemical binding]; other site 290340010094 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340010095 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010096 putative active site [active] 290340010097 urate oxidase; Region: urate_oxi; TIGR03383 290340010098 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290340010099 active site 290340010100 xanthine permease; Region: pbuX; TIGR03173 290340010101 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290340010102 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340010103 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010104 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010105 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 290340010106 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290340010107 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290340010108 putative NAD(P) binding site [chemical binding]; other site 290340010109 malate synthase A; Region: malate_syn_A; TIGR01344 290340010110 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290340010111 active site 290340010112 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290340010113 hypothetical protein; Provisional; Region: PRK11171 290340010114 Cupin domain; Region: Cupin_2; pfam07883 290340010115 Protein of unknown function (DUF419); Region: DUF419; pfam04237 290340010116 Protein of unknown function (DUF664); Region: DUF664; pfam04978 290340010117 DinB superfamily; Region: DinB_2; pfam12867 290340010118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010119 benzoate transport; Region: 2A0115; TIGR00895 290340010120 putative substrate translocation pore; other site 290340010121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010122 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290340010123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340010124 ATP binding site [chemical binding]; other site 290340010125 Mg2+ binding site [ion binding]; other site 290340010126 G-X-G motif; other site 290340010127 Transglycosylase; Region: Transgly; pfam00912 290340010128 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290340010129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290340010130 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340010131 catalytic triad [active] 290340010132 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290340010133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010134 putative substrate translocation pore; other site 290340010135 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 290340010136 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 290340010137 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290340010138 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290340010139 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 290340010140 active site clefts [active] 290340010141 zinc binding site [ion binding]; other site 290340010142 dimer interface [polypeptide binding]; other site 290340010143 FG-GAP repeat; Region: FG-GAP; cl15299 290340010144 Family description; Region: VCBS; pfam13517 290340010145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340010146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340010147 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 290340010148 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290340010149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010150 S-adenosylmethionine binding site [chemical binding]; other site 290340010151 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340010152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340010153 active site 290340010154 adenylate kinase; Reviewed; Region: adk; PRK00279 290340010155 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340010156 AMP-binding site [chemical binding]; other site 290340010157 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340010158 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340010159 putative hydrophobic ligand binding site [chemical binding]; other site 290340010160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340010161 dimerization interface [polypeptide binding]; other site 290340010162 putative DNA binding site [nucleotide binding]; other site 290340010163 putative Zn2+ binding site [ion binding]; other site 290340010164 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290340010165 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290340010166 putative active site [active] 290340010167 benzoate transport; Region: 2A0115; TIGR00895 290340010168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010169 putative substrate translocation pore; other site 290340010170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010171 GAF domain; Region: GAF; cl17456 290340010172 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290340010173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340010174 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 290340010175 active site 290340010176 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290340010177 putative hydrophobic ligand binding site [chemical binding]; other site 290340010178 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 290340010179 metal binding site [ion binding]; metal-binding site 290340010180 active site 290340010181 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290340010182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340010183 Walker A/P-loop; other site 290340010184 ATP binding site [chemical binding]; other site 290340010185 Q-loop/lid; other site 290340010186 ABC transporter signature motif; other site 290340010187 Walker B; other site 290340010188 D-loop; other site 290340010189 H-loop/switch region; other site 290340010190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340010191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340010192 Walker A/P-loop; other site 290340010193 ATP binding site [chemical binding]; other site 290340010194 Q-loop/lid; other site 290340010195 ABC transporter signature motif; other site 290340010196 Walker B; other site 290340010197 D-loop; other site 290340010198 H-loop/switch region; other site 290340010199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340010200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290340010201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010202 ABC-ATPase subunit interface; other site 290340010203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340010204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010205 dimer interface [polypeptide binding]; other site 290340010206 conserved gate region; other site 290340010207 putative PBP binding loops; other site 290340010208 ABC-ATPase subunit interface; other site 290340010209 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 290340010210 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340010211 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010212 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010213 active site 290340010214 non-prolyl cis peptide bond; other site 290340010215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010216 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010217 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340010219 active site residue [active] 290340010220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010221 putative substrate translocation pore; other site 290340010222 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290340010223 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 290340010224 dimer interface [polypeptide binding]; other site 290340010225 active site 290340010226 non-prolyl cis peptide bond; other site 290340010227 insertion regions; other site 290340010228 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 290340010229 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290340010230 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290340010231 Walker A/P-loop; other site 290340010232 ATP binding site [chemical binding]; other site 290340010233 Q-loop/lid; other site 290340010234 ABC transporter signature motif; other site 290340010235 Walker B; other site 290340010236 D-loop; other site 290340010237 H-loop/switch region; other site 290340010238 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290340010239 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010240 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010241 active site 290340010242 non-prolyl cis peptide bond; other site 290340010243 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290340010244 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290340010245 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290340010246 DXD motif; other site 290340010247 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 290340010248 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 290340010249 active site 290340010250 catalytic residues [active] 290340010251 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290340010252 nudix motif; other site 290340010253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010254 TAP-like protein; Region: Abhydrolase_4; pfam08386 290340010255 MOSC domain; Region: MOSC; pfam03473 290340010256 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340010257 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290340010258 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340010259 Walker A/P-loop; other site 290340010260 ATP binding site [chemical binding]; other site 290340010261 Q-loop/lid; other site 290340010262 ABC transporter signature motif; other site 290340010263 Walker B; other site 290340010264 D-loop; other site 290340010265 H-loop/switch region; other site 290340010266 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290340010267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290340010268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010269 Walker A/P-loop; other site 290340010270 ATP binding site [chemical binding]; other site 290340010271 Q-loop/lid; other site 290340010272 ABC transporter signature motif; other site 290340010273 Walker B; other site 290340010274 D-loop; other site 290340010275 H-loop/switch region; other site 290340010276 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 290340010277 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340010278 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290340010279 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340010280 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290340010281 TAP-like protein; Region: Abhydrolase_4; pfam08386 290340010282 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 290340010283 putative active site; other site 290340010284 putative metal binding residues [ion binding]; other site 290340010285 signature motif; other site 290340010286 putative triphosphate binding site [ion binding]; other site 290340010287 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 290340010288 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290340010289 putative hydrophobic ligand binding site [chemical binding]; other site 290340010290 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010291 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340010292 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010293 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340010294 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340010295 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 290340010296 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290340010297 substrate binding site [chemical binding]; other site 290340010298 oxyanion hole (OAH) forming residues; other site 290340010299 trimer interface [polypeptide binding]; other site 290340010300 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 290340010301 thymidylate kinase; Validated; Region: tmk; PRK00698 290340010302 active site 290340010303 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 290340010304 nudix motif; other site 290340010305 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 290340010306 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 290340010307 NADH kinase; Region: PLN02929 290340010308 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 290340010309 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 290340010310 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 290340010311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010312 Walker A/P-loop; other site 290340010313 ATP binding site [chemical binding]; other site 290340010314 Q-loop/lid; other site 290340010315 ABC transporter signature motif; other site 290340010316 Walker B; other site 290340010317 D-loop; other site 290340010318 H-loop/switch region; other site 290340010319 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290340010320 Peptidase family M50; Region: Peptidase_M50; pfam02163 290340010321 active site 290340010322 putative substrate binding region [chemical binding]; other site 290340010323 YcaO-like family; Region: YcaO; pfam02624 290340010324 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 290340010325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010326 S-adenosylmethionine binding site [chemical binding]; other site 290340010327 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340010328 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290340010329 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290340010330 active site 290340010331 NAD binding site [chemical binding]; other site 290340010332 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 290340010333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290340010334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340010335 catalytic residue [active] 290340010336 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290340010337 conserved cys residue [active] 290340010338 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340010339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340010340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340010341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010343 dimer interface [polypeptide binding]; other site 290340010344 conserved gate region; other site 290340010345 putative PBP binding loops; other site 290340010346 ABC-ATPase subunit interface; other site 290340010347 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290340010348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010349 dimer interface [polypeptide binding]; other site 290340010350 conserved gate region; other site 290340010351 putative PBP binding loops; other site 290340010352 ABC-ATPase subunit interface; other site 290340010353 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340010354 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340010355 uridine kinase; Validated; Region: PRK06696 290340010356 active site 290340010357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340010358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010359 DNA binding site [nucleotide binding] 290340010360 domain linker motif; other site 290340010361 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290340010362 ligand binding site [chemical binding]; other site 290340010363 dimerization interface [polypeptide binding]; other site 290340010364 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 290340010365 AAA domain; Region: AAA_23; pfam13476 290340010366 AAA domain; Region: AAA_21; pfam13304 290340010367 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 290340010368 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290340010369 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290340010370 glyoxylate carboligase; Provisional; Region: PRK11269 290340010371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290340010372 PYR/PP interface [polypeptide binding]; other site 290340010373 dimer interface [polypeptide binding]; other site 290340010374 TPP binding site [chemical binding]; other site 290340010375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290340010376 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290340010377 TPP-binding site [chemical binding]; other site 290340010378 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290340010379 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 290340010380 allantoinase; Region: allantoinase; TIGR03178 290340010381 active site 290340010382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340010383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340010384 DNA binding site [nucleotide binding] 290340010385 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290340010386 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290340010387 catalytic triad [active] 290340010388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340010389 Response regulator receiver domain; Region: Response_reg; pfam00072 290340010390 active site 290340010391 phosphorylation site [posttranslational modification] 290340010392 intermolecular recognition site; other site 290340010393 dimerization interface [polypeptide binding]; other site 290340010394 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 290340010395 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 290340010396 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290340010397 DXD motif; other site 290340010398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290340010399 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290340010400 anti sigma factor interaction site; other site 290340010401 regulatory phosphorylation site [posttranslational modification]; other site 290340010402 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290340010403 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 290340010404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340010405 catalytic residue [active] 290340010406 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340010407 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340010408 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290340010409 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290340010410 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290340010411 active site 290340010412 OHCU decarboxylase; Region: UraD_2; TIGR03180 290340010413 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 290340010414 active site 290340010415 homotetramer interface [polypeptide binding]; other site 290340010416 amidophosphoribosyltransferase; Provisional; Region: PRK07847 290340010417 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290340010418 active site 290340010419 tetramer interface [polypeptide binding]; other site 290340010420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290340010421 active site 290340010422 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290340010423 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290340010424 dimerization interface [polypeptide binding]; other site 290340010425 putative ATP binding site [chemical binding]; other site 290340010426 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340010427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340010428 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340010429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340010430 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340010431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340010432 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340010433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340010434 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 290340010435 Septum formation; Region: Septum_form; pfam13845 290340010436 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290340010437 Clp amino terminal domain; Region: Clp_N; pfam02861 290340010438 Clp amino terminal domain; Region: Clp_N; pfam02861 290340010439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340010440 Walker A motif; other site 290340010441 ATP binding site [chemical binding]; other site 290340010442 Walker B motif; other site 290340010443 arginine finger; other site 290340010444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340010445 Walker A motif; other site 290340010446 ATP binding site [chemical binding]; other site 290340010447 Walker B motif; other site 290340010448 arginine finger; other site 290340010449 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290340010450 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 290340010451 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 290340010452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010453 Walker A/P-loop; other site 290340010454 ATP binding site [chemical binding]; other site 290340010455 Q-loop/lid; other site 290340010456 ABC transporter signature motif; other site 290340010457 Walker B; other site 290340010458 D-loop; other site 290340010459 H-loop/switch region; other site 290340010460 TOBE domain; Region: TOBE; pfam03459 290340010461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010462 putative PBP binding loops; other site 290340010463 ABC-ATPase subunit interface; other site 290340010464 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290340010465 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290340010466 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340010467 DNA binding residues [nucleotide binding] 290340010468 TOBE domain; Region: TOBE; cl01440 290340010469 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290340010470 FAD binding domain; Region: FAD_binding_4; pfam01565 290340010471 Berberine and berberine like; Region: BBE; pfam08031 290340010472 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 290340010473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 290340010474 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290340010475 catalytic site [active] 290340010476 BNR repeat-like domain; Region: BNR_2; pfam13088 290340010477 Asp-box motif; other site 290340010478 hypothetical protein; Provisional; Region: PRK11770 290340010479 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290340010480 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290340010481 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290340010482 putative hydrophobic ligand binding site [chemical binding]; other site 290340010483 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 290340010484 active site 290340010485 HutD; Region: HutD; pfam05962 290340010486 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 290340010487 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 290340010488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340010490 active site 290340010491 catalytic tetrad [active] 290340010492 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290340010493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290340010494 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340010495 ATP binding site [chemical binding]; other site 290340010496 putative Mg++ binding site [ion binding]; other site 290340010497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340010498 nucleotide binding region [chemical binding]; other site 290340010499 ATP-binding site [chemical binding]; other site 290340010500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010501 putative substrate translocation pore; other site 290340010502 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 290340010503 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 290340010504 DNA binding residues [nucleotide binding] 290340010505 dimer interface [polypeptide binding]; other site 290340010506 [2Fe-2S] cluster binding site [ion binding]; other site 290340010507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010508 S-adenosylmethionine binding site [chemical binding]; other site 290340010509 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340010510 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340010511 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290340010512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 290340010513 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340010514 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290340010515 metal binding site [ion binding]; metal-binding site 290340010516 dimer interface [polypeptide binding]; other site 290340010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010518 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010519 putative substrate translocation pore; other site 290340010520 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290340010521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010522 putative substrate translocation pore; other site 290340010523 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 290340010524 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 290340010525 hydrophobic ligand binding site; other site 290340010526 Putative zinc-finger; Region: zf-HC2; pfam13490 290340010527 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 290340010528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340010530 DNA binding residues [nucleotide binding] 290340010531 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290340010532 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290340010533 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340010534 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010535 putative active site [active] 290340010536 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 290340010537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340010538 Walker A/P-loop; other site 290340010539 ATP binding site [chemical binding]; other site 290340010540 Q-loop/lid; other site 290340010541 ABC transporter signature motif; other site 290340010542 Walker B; other site 290340010543 D-loop; other site 290340010544 H-loop/switch region; other site 290340010545 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 290340010546 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 290340010547 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 290340010548 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 290340010549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340010550 ATP binding site [chemical binding]; other site 290340010551 putative Mg++ binding site [ion binding]; other site 290340010552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340010553 nucleotide binding region [chemical binding]; other site 290340010554 ATP-binding site [chemical binding]; other site 290340010555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340010556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010557 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340010558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340010559 DNA-binding site [nucleotide binding]; DNA binding site 290340010560 FCD domain; Region: FCD; pfam07729 290340010561 amidase; Validated; Region: PRK06565 290340010562 Amidase; Region: Amidase; cl11426 290340010563 Agmatine deiminase; Region: PLN02690 290340010564 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 290340010565 glycogen branching enzyme; Provisional; Region: PRK14705 290340010566 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 290340010567 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290340010568 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010569 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340010570 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010571 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340010572 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340010573 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340010574 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290340010575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290340010576 NAD(P) binding site [chemical binding]; other site 290340010577 transketolase; Reviewed; Region: PRK05899 290340010578 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340010579 TPP-binding site [chemical binding]; other site 290340010580 dimer interface [polypeptide binding]; other site 290340010581 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340010582 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340010583 PYR/PP interface [polypeptide binding]; other site 290340010584 dimer interface [polypeptide binding]; other site 290340010585 TPP binding site [chemical binding]; other site 290340010586 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340010587 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340010588 ATP binding site [chemical binding]; other site 290340010589 substrate binding site [chemical binding]; other site 290340010590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340010591 classical (c) SDRs; Region: SDR_c; cd05233 290340010592 NAD(P) binding site [chemical binding]; other site 290340010593 active site 290340010594 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290340010595 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290340010596 NAD(P) binding site [chemical binding]; other site 290340010597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010598 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340010599 putative substrate translocation pore; other site 290340010600 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290340010601 classical (c) SDRs; Region: SDR_c; cd05233 290340010602 NAD(P) binding site [chemical binding]; other site 290340010603 active site 290340010604 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 290340010605 DNA binding residues [nucleotide binding] 290340010606 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340010607 putative dimer interface [polypeptide binding]; other site 290340010608 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290340010609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340010610 nucleotide binding site [chemical binding]; other site 290340010611 Protein of unknown function (DUF817); Region: DUF817; pfam05675 290340010612 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 290340010613 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340010614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340010615 NAD(P) binding site [chemical binding]; other site 290340010616 active site 290340010617 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290340010618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340010619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340010620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340010621 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290340010622 catalytic site [active] 290340010623 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 290340010624 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340010625 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290340010626 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340010627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340010628 motif II; other site 290340010629 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290340010630 PhoD-like phosphatase; Region: PhoD; pfam09423 290340010631 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290340010632 putative active site [active] 290340010633 putative metal binding site [ion binding]; other site 290340010634 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290340010635 choline dehydrogenase; Validated; Region: PRK02106 290340010636 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290340010637 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 290340010638 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 290340010639 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 290340010640 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290340010641 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 290340010642 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 290340010643 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 290340010644 phage tail protein domain; Region: tail_TIGR02242 290340010645 aminotransferase AlaT; Validated; Region: PRK09265 290340010646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340010647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010648 homodimer interface [polypeptide binding]; other site 290340010649 catalytic residue [active] 290340010650 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340010651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340010652 DNA binding residues [nucleotide binding] 290340010653 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 290340010654 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 290340010655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340010656 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340010657 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290340010658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340010659 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340010660 NAD(P) binding site [chemical binding]; other site 290340010661 catalytic residues [active] 290340010662 prephenate dehydratase; Provisional; Region: PRK11899 290340010663 Prephenate dehydratase; Region: PDT; pfam00800 290340010664 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290340010665 putative L-Phe binding site [chemical binding]; other site 290340010666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290340010667 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 290340010668 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340010669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340010670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340010671 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340010672 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340010673 active site 290340010674 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340010675 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340010676 active site 290340010677 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290340010678 amphipathic channel; other site 290340010679 Asn-Pro-Ala signature motifs; other site 290340010680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340010681 dimerization interface [polypeptide binding]; other site 290340010682 putative DNA binding site [nucleotide binding]; other site 290340010683 putative Zn2+ binding site [ion binding]; other site 290340010684 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290340010685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340010686 MMPL family; Region: MMPL; pfam03176 290340010687 Protein export membrane protein; Region: SecD_SecF; cl14618 290340010688 MarR family; Region: MarR_2; pfam12802 290340010689 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340010690 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290340010691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340010692 S-adenosylmethionine binding site [chemical binding]; other site 290340010693 YCII-related domain; Region: YCII; cl00999 290340010694 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 290340010695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340010696 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290340010697 DNA binding residues [nucleotide binding] 290340010698 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340010699 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340010700 active site 290340010701 catalytic tetrad [active] 290340010702 DNA polymerase IV; Validated; Region: PRK03352 290340010703 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290340010704 active site 290340010705 DNA binding site [nucleotide binding] 290340010706 LysE type translocator; Region: LysE; cl00565 290340010707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340010708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010709 DNA binding site [nucleotide binding] 290340010710 domain linker motif; other site 290340010711 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010712 dimerization interface [polypeptide binding]; other site 290340010713 ligand binding site [chemical binding]; other site 290340010714 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290340010715 active site 290340010716 tetramer interface [polypeptide binding]; other site 290340010717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340010719 putative substrate translocation pore; other site 290340010720 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290340010721 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340010722 substrate binding site [chemical binding]; other site 290340010723 dimer interface [polypeptide binding]; other site 290340010724 ATP binding site [chemical binding]; other site 290340010725 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340010726 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290340010727 active site 290340010728 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 290340010729 AAA domain; Region: AAA_18; pfam13238 290340010730 active site 290340010731 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290340010732 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 290340010733 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290340010734 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290340010735 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290340010736 putative active site [active] 290340010737 catalytic site [active] 290340010738 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290340010739 putative active site [active] 290340010740 catalytic site [active] 290340010741 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290340010742 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 290340010743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010744 catalytic residue [active] 290340010745 S-methylmethionine transporter; Provisional; Region: PRK11387 290340010746 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290340010747 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290340010748 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340010749 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290340010750 dimer interface [polypeptide binding]; other site 290340010751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010752 catalytic residue [active] 290340010753 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290340010754 active sites [active] 290340010755 tetramer interface [polypeptide binding]; other site 290340010756 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010757 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010758 active site 290340010759 non-prolyl cis peptide bond; other site 290340010760 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290340010761 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290340010762 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290340010763 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290340010764 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 290340010765 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340010766 active site residue [active] 290340010767 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 290340010768 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290340010769 homodimer interface [polypeptide binding]; other site 290340010770 substrate-cofactor binding pocket; other site 290340010771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340010772 catalytic residue [active] 290340010773 carboxylate-amine ligase; Provisional; Region: PRK13517 290340010774 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290340010775 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290340010776 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 290340010777 putative active site [active] 290340010778 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340010779 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340010780 FAD binding pocket [chemical binding]; other site 290340010781 FAD binding motif [chemical binding]; other site 290340010782 phosphate binding motif [ion binding]; other site 290340010783 NAD binding pocket [chemical binding]; other site 290340010784 Penicillin amidase; Region: Penicil_amidase; pfam01804 290340010785 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 290340010786 active site 290340010787 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290340010788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290340010789 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 290340010790 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290340010791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340010792 Walker A/P-loop; other site 290340010793 ATP binding site [chemical binding]; other site 290340010794 Q-loop/lid; other site 290340010795 ABC transporter signature motif; other site 290340010796 Walker B; other site 290340010797 D-loop; other site 290340010798 H-loop/switch region; other site 290340010799 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290340010800 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 290340010801 Walker A/P-loop; other site 290340010802 ATP binding site [chemical binding]; other site 290340010803 Q-loop/lid; other site 290340010804 ABC transporter signature motif; other site 290340010805 Walker B; other site 290340010806 D-loop; other site 290340010807 H-loop/switch region; other site 290340010808 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 290340010809 NUDIX domain; Region: NUDIX; pfam00293 290340010810 nudix motif; other site 290340010811 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 290340010812 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 290340010813 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 290340010814 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 290340010815 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 290340010816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290340010817 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 290340010818 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 290340010819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290340010820 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 290340010821 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 290340010822 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 290340010823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010824 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 290340010825 TrkA-C domain; Region: TrkA_C; pfam02080 290340010826 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 290340010827 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290340010828 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290340010829 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010830 putative active site [active] 290340010831 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290340010832 trimer interface [polypeptide binding]; other site 290340010833 active site 290340010834 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 290340010835 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290340010836 hydrophobic ligand binding site; other site 290340010837 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 290340010838 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 290340010839 SnoaL-like domain; Region: SnoaL_2; pfam12680 290340010840 alanine dehydrogenase; Region: alaDH; TIGR00518 290340010841 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 290340010842 putative active site [active] 290340010843 putative ligand binding site [chemical binding]; other site 290340010844 putative NAD(P) binding site [chemical binding]; other site 290340010845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340010846 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340010847 putative substrate translocation pore; other site 290340010848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340010849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340010850 dimerization interface [polypeptide binding]; other site 290340010851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290340010852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010853 Coenzyme A binding pocket [chemical binding]; other site 290340010854 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340010855 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290340010856 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340010857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010858 DNA binding site [nucleotide binding] 290340010859 domain linker motif; other site 290340010860 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290340010861 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010862 dimerization interface [polypeptide binding]; other site 290340010863 ligand binding site [chemical binding]; other site 290340010864 Protein of unknown function (DUF993); Region: DUF993; pfam06187 290340010865 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340010866 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 290340010867 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 290340010868 MarR family; Region: MarR_2; pfam12802 290340010869 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290340010870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340010871 xylose isomerase; Provisional; Region: PRK12677 290340010872 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 290340010873 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290340010874 D-xylulose kinase; Region: XylB; TIGR01312 290340010875 nucleotide binding site [chemical binding]; other site 290340010876 lac repressor; Reviewed; Region: lacI; PRK09526 290340010877 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010878 DNA binding site [nucleotide binding] 290340010879 domain linker motif; other site 290340010880 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290340010881 ligand binding site [chemical binding]; other site 290340010882 dimerization interface (open form) [polypeptide binding]; other site 290340010883 dimerization interface (closed form) [polypeptide binding]; other site 290340010884 ribulokinase; Provisional; Region: PRK04123 290340010885 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 290340010886 N- and C-terminal domain interface [polypeptide binding]; other site 290340010887 active site 290340010888 MgATP binding site [chemical binding]; other site 290340010889 catalytic site [active] 290340010890 metal binding site [ion binding]; metal-binding site 290340010891 carbohydrate binding site [chemical binding]; other site 290340010892 homodimer interface [polypeptide binding]; other site 290340010893 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 290340010894 intersubunit interface [polypeptide binding]; other site 290340010895 active site 290340010896 Zn2+ binding site [ion binding]; other site 290340010897 L-arabinose isomerase; Provisional; Region: PRK02929 290340010898 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 290340010899 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 290340010900 trimer interface [polypeptide binding]; other site 290340010901 putative substrate binding site [chemical binding]; other site 290340010902 putative metal binding site [ion binding]; other site 290340010903 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290340010904 active site 290340010905 catalytic residues [active] 290340010906 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340010907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340010908 DNA binding site [nucleotide binding] 290340010909 domain linker motif; other site 290340010910 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340010911 dimerization interface [polypeptide binding]; other site 290340010912 ligand binding site [chemical binding]; other site 290340010913 Domain of unknown function (DUF718); Region: DUF718; pfam05336 290340010914 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 290340010915 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 290340010916 short chain dehydrogenase; Validated; Region: PRK08324 290340010917 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 290340010918 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290340010919 putative NAD(P) binding site [chemical binding]; other site 290340010920 active site 290340010921 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 290340010922 N- and C-terminal domain interface [polypeptide binding]; other site 290340010923 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 290340010924 active site 290340010925 putative catalytic site [active] 290340010926 metal binding site [ion binding]; metal-binding site 290340010927 ATP binding site [chemical binding]; other site 290340010928 carbohydrate binding site [chemical binding]; other site 290340010929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340010930 non-specific DNA binding site [nucleotide binding]; other site 290340010931 salt bridge; other site 290340010932 sequence-specific DNA binding site [nucleotide binding]; other site 290340010933 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290340010934 tetramerization interface [polypeptide binding]; other site 290340010935 active site 290340010936 Predicted permeases [General function prediction only]; Region: COG0679 290340010937 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 290340010938 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290340010939 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290340010940 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 290340010941 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010942 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340010943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340010944 substrate binding pocket [chemical binding]; other site 290340010945 membrane-bound complex binding site; other site 290340010946 hinge residues; other site 290340010947 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 290340010948 threonine dehydratase; Provisional; Region: PRK08246 290340010949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340010950 catalytic residue [active] 290340010951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290340010952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010953 Coenzyme A binding pocket [chemical binding]; other site 290340010954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340010955 Family description; Region: VCBS; pfam13517 290340010956 FG-GAP repeat; Region: FG-GAP; pfam01839 290340010957 Family description; Region: VCBS; pfam13517 290340010958 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290340010959 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290340010960 active site 290340010961 non-prolyl cis peptide bond; other site 290340010962 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340010963 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290340010964 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290340010965 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290340010966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340010967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290340010968 substrate binding pocket [chemical binding]; other site 290340010969 membrane-bound complex binding site; other site 290340010970 hinge residues; other site 290340010971 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290340010972 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290340010973 Walker A/P-loop; other site 290340010974 ATP binding site [chemical binding]; other site 290340010975 Q-loop/lid; other site 290340010976 ABC transporter signature motif; other site 290340010977 Walker B; other site 290340010978 D-loop; other site 290340010979 H-loop/switch region; other site 290340010980 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290340010981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340010982 dimer interface [polypeptide binding]; other site 290340010983 conserved gate region; other site 290340010984 putative PBP binding loops; other site 290340010985 ABC-ATPase subunit interface; other site 290340010986 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 290340010987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340010988 Coenzyme A binding pocket [chemical binding]; other site 290340010989 AAA-like domain; Region: AAA_10; pfam12846 290340010990 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290340010991 putative active site [active] 290340010992 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340010993 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340010994 Copper resistance protein D; Region: CopD; cl00563 290340010995 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290340010996 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290340010997 IHF dimer interface [polypeptide binding]; other site 290340010998 IHF - DNA interface [nucleotide binding]; other site 290340010999 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340011000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340011001 Patatin-like phospholipase; Region: Patatin; pfam01734 290340011002 active site 290340011003 nucleophile elbow; other site 290340011004 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340011005 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 290340011006 DNA binding site [nucleotide binding] 290340011007 Bacterial transcriptional activator domain; Region: BTAD; smart01043 290340011008 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 290340011009 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 290340011010 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 290340011011 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340011012 active site 290340011013 catalytic triad [active] 290340011014 oxyanion hole [active] 290340011015 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340011016 MarR family; Region: MarR_2; cl17246 290340011017 YCII-related domain; Region: YCII; cl00999 290340011018 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340011019 active site 290340011020 catalytic triad [active] 290340011021 oxyanion hole [active] 290340011022 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290340011023 active site 290340011024 catalytic triad [active] 290340011025 oxyanion hole [active] 290340011026 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290340011027 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290340011028 FAD binding pocket [chemical binding]; other site 290340011029 FAD binding motif [chemical binding]; other site 290340011030 phosphate binding motif [ion binding]; other site 290340011031 NAD binding pocket [chemical binding]; other site 290340011032 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290340011033 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340011034 Walker A/P-loop; other site 290340011035 ATP binding site [chemical binding]; other site 290340011036 Q-loop/lid; other site 290340011037 ABC transporter signature motif; other site 290340011038 Walker B; other site 290340011039 D-loop; other site 290340011040 H-loop/switch region; other site 290340011041 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 290340011042 FecCD transport family; Region: FecCD; pfam01032 290340011043 dimer interface [polypeptide binding]; other site 290340011044 putative PBP binding regions; other site 290340011045 ABC-ATPase subunit interface; other site 290340011046 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340011047 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340011048 dimer interface [polypeptide binding]; other site 290340011049 putative PBP binding regions; other site 290340011050 ABC-ATPase subunit interface; other site 290340011051 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290340011052 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340011053 intersubunit interface [polypeptide binding]; other site 290340011054 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 290340011055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 290340011056 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 290340011057 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290340011058 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 290340011059 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 290340011060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340011061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290340011062 active site 290340011063 SEC-C motif; Region: SEC-C; pfam02810 290340011064 hypothetical protein; Provisional; Region: PRK01842 290340011065 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290340011066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340011067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340011068 active site 290340011069 catalytic tetrad [active] 290340011070 sulfite oxidase; Provisional; Region: PLN00177 290340011071 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 290340011072 Moco binding site; other site 290340011073 metal coordination site [ion binding]; other site 290340011074 dimerization interface [polypeptide binding]; other site 290340011075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340011076 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340011077 active site 290340011078 catalytic tetrad [active] 290340011079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011080 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290340011081 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290340011082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340011083 S-adenosylmethionine binding site [chemical binding]; other site 290340011084 PQQ-like domain; Region: PQQ_2; pfam13360 290340011085 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 290340011086 active site 290340011087 Trp docking motif [polypeptide binding]; other site 290340011088 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 290340011089 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290340011090 Arginase family; Region: Arginase; pfam00491 290340011091 active site 290340011092 metal binding site [ion binding]; metal-binding site 290340011093 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290340011094 RNA binding surface [nucleotide binding]; other site 290340011095 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 290340011096 transcriptional regulator NanR; Provisional; Region: PRK03837 290340011097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011098 DNA-binding site [nucleotide binding]; DNA binding site 290340011099 FCD domain; Region: FCD; pfam07729 290340011100 L-asparaginase II; Region: Asparaginase_II; pfam06089 290340011101 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290340011102 Aspartase; Region: Aspartase; cd01357 290340011103 active sites [active] 290340011104 tetramer interface [polypeptide binding]; other site 290340011105 L-asparagine permease; Provisional; Region: PRK15049 290340011106 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290340011107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011108 DNA-binding site [nucleotide binding]; DNA binding site 290340011109 FCD domain; Region: FCD; pfam07729 290340011110 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 290340011111 Amidohydrolase; Region: Amidohydro_2; pfam04909 290340011112 active site 290340011113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290340011114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290340011115 active site 290340011116 catalytic tetrad [active] 290340011117 Domain of unknown function (DUF718); Region: DUF718; pfam05336 290340011118 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 290340011119 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 290340011120 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 290340011121 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290340011122 putative active site pocket [active] 290340011123 metal binding site [ion binding]; metal-binding site 290340011124 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340011125 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340011126 classical (c) SDRs; Region: SDR_c; cd05233 290340011127 NAD(P) binding site [chemical binding]; other site 290340011128 active site 290340011129 Family description; Region: VCBS; pfam13517 290340011130 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011131 Family description; Region: VCBS; pfam13517 290340011132 Family description; Region: VCBS; pfam13517 290340011133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340011134 Coenzyme A binding pocket [chemical binding]; other site 290340011135 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340011136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340011137 Walker A motif; other site 290340011138 ATP binding site [chemical binding]; other site 290340011139 Walker B motif; other site 290340011140 arginine finger; other site 290340011141 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 290340011142 HD domain; Region: HD_4; pfam13328 290340011143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340011144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340011145 WHG domain; Region: WHG; pfam13305 290340011146 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340011147 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340011148 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 290340011149 active site 290340011150 HIGH motif; other site 290340011151 nucleotide binding site [chemical binding]; other site 290340011152 active site 290340011153 KMSKS motif; other site 290340011154 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340011155 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290340011156 AsnC family; Region: AsnC_trans_reg; pfam01037 290340011157 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340011158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011159 putative DNA binding site [nucleotide binding]; other site 290340011160 putative Zn2+ binding site [ion binding]; other site 290340011161 AsnC family; Region: AsnC_trans_reg; pfam01037 290340011162 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290340011163 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 290340011164 putative hydrophobic ligand binding site [chemical binding]; other site 290340011165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011166 dimerization interface [polypeptide binding]; other site 290340011167 putative DNA binding site [nucleotide binding]; other site 290340011168 putative Zn2+ binding site [ion binding]; other site 290340011169 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290340011170 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011172 putative Zn2+ binding site [ion binding]; other site 290340011173 putative DNA binding site [nucleotide binding]; other site 290340011174 dimerization interface [polypeptide binding]; other site 290340011175 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011176 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290340011177 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290340011178 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 290340011179 active site 290340011180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011181 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011182 putative substrate translocation pore; other site 290340011183 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340011184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011185 DNA-binding site [nucleotide binding]; DNA binding site 290340011186 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290340011187 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340011188 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340011189 dimer interface [polypeptide binding]; other site 290340011190 active site 290340011191 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340011192 folate binding site [chemical binding]; other site 290340011193 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 290340011194 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340011195 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290340011196 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 290340011197 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 290340011198 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 290340011199 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340011200 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 290340011201 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340011202 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340011203 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290340011204 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290340011205 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290340011206 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290340011207 putative active site [active] 290340011208 putative substrate binding site [chemical binding]; other site 290340011209 putative cosubstrate binding site; other site 290340011210 catalytic site [active] 290340011211 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340011212 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340011213 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290340011214 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290340011215 Na binding site [ion binding]; other site 290340011216 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 290340011217 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 290340011218 active site 290340011219 catalytic site [active] 290340011220 Zn binding site [ion binding]; other site 290340011221 tetramer interface [polypeptide binding]; other site 290340011222 Protein of unknown function (DUF456); Region: DUF456; pfam04306 290340011223 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 290340011224 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290340011225 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 290340011226 NAD(P) binding pocket [chemical binding]; other site 290340011227 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011228 Family description; Region: VCBS; pfam13517 290340011229 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011230 Family description; Region: VCBS; pfam13517 290340011231 Family description; Region: VCBS; pfam13517 290340011232 Family description; Region: VCBS; pfam13517 290340011233 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 290340011234 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 290340011235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340011237 putative substrate translocation pore; other site 290340011238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011239 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 290340011240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011241 putative substrate translocation pore; other site 290340011242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290340011245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340011246 putative DNA binding site [nucleotide binding]; other site 290340011247 putative Zn2+ binding site [ion binding]; other site 290340011248 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290340011249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340011250 Coenzyme A binding pocket [chemical binding]; other site 290340011251 Predicted transcriptional regulators [Transcription]; Region: COG1695 290340011252 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290340011253 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 290340011254 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290340011255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340011256 Walker A/P-loop; other site 290340011257 ATP binding site [chemical binding]; other site 290340011258 Q-loop/lid; other site 290340011259 ABC transporter signature motif; other site 290340011260 Walker B; other site 290340011261 D-loop; other site 290340011262 H-loop/switch region; other site 290340011263 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290340011264 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290340011265 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290340011266 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 290340011267 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290340011268 Walker A/P-loop; other site 290340011269 ATP binding site [chemical binding]; other site 290340011270 Q-loop/lid; other site 290340011271 ABC transporter signature motif; other site 290340011272 Walker B; other site 290340011273 D-loop; other site 290340011274 H-loop/switch region; other site 290340011275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290340011276 ABC-ATPase subunit interface; other site 290340011277 dimer interface [polypeptide binding]; other site 290340011278 putative PBP binding regions; other site 290340011279 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290340011280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290340011281 ABC-ATPase subunit interface; other site 290340011282 dimer interface [polypeptide binding]; other site 290340011283 putative PBP binding regions; other site 290340011284 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 290340011285 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290340011286 putative ligand binding residues [chemical binding]; other site 290340011287 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 290340011288 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290340011289 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290340011290 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 290340011291 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 290340011292 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290340011293 active site 290340011294 P-loop; other site 290340011295 phosphorylation site [posttranslational modification] 290340011296 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290340011297 active site 290340011298 phosphorylation site [posttranslational modification] 290340011299 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290340011300 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290340011301 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290340011302 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290340011303 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290340011304 dimerization domain swap beta strand [polypeptide binding]; other site 290340011305 regulatory protein interface [polypeptide binding]; other site 290340011306 active site 290340011307 regulatory phosphorylation site [posttranslational modification]; other site 290340011308 Helix-turn-helix domain; Region: HTH_17; pfam12728 290340011309 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 290340011310 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290340011311 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011312 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290340011313 catalytic site [active] 290340011314 TAP-like protein; Region: Abhydrolase_4; pfam08386 290340011315 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 290340011316 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 290340011317 active site 290340011318 DNA binding site [nucleotide binding] 290340011319 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 290340011320 DNA binding site [nucleotide binding] 290340011321 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340011322 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340011323 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290340011324 hexamer interface [polypeptide binding]; other site 290340011325 ligand binding site [chemical binding]; other site 290340011326 putative active site [active] 290340011327 NAD(P) binding site [chemical binding]; other site 290340011328 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290340011329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340011330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340011331 DNA binding residues [nucleotide binding] 290340011332 putative oxidoreductase; Provisional; Region: PRK11579 290340011333 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340011334 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340011335 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 290340011336 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290340011337 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 290340011338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340011339 Walker A/P-loop; other site 290340011340 ATP binding site [chemical binding]; other site 290340011341 Q-loop/lid; other site 290340011342 ABC transporter signature motif; other site 290340011343 Walker B; other site 290340011344 D-loop; other site 290340011345 H-loop/switch region; other site 290340011346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290340011347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290340011348 Walker A/P-loop; other site 290340011349 ATP binding site [chemical binding]; other site 290340011350 Q-loop/lid; other site 290340011351 ABC transporter signature motif; other site 290340011352 Walker B; other site 290340011353 D-loop; other site 290340011354 H-loop/switch region; other site 290340011355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290340011356 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290340011357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011358 dimer interface [polypeptide binding]; other site 290340011359 conserved gate region; other site 290340011360 putative PBP binding loops; other site 290340011361 ABC-ATPase subunit interface; other site 290340011362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290340011363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011364 dimer interface [polypeptide binding]; other site 290340011365 conserved gate region; other site 290340011366 putative PBP binding loops; other site 290340011367 ABC-ATPase subunit interface; other site 290340011368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340011369 Predicted flavoprotein [General function prediction only]; Region: COG0431 290340011370 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290340011371 Sporulation and spore germination; Region: Germane; pfam10646 290340011372 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340011373 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340011374 tetramer interface [polypeptide binding]; other site 290340011375 active site 290340011376 Mg2+/Mn2+ binding site [ion binding]; other site 290340011377 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290340011378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340011379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011380 homodimer interface [polypeptide binding]; other site 290340011381 catalytic residue [active] 290340011382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340011383 Ligand Binding Site [chemical binding]; other site 290340011384 Amino acid permease; Region: AA_permease_2; pfam13520 290340011385 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340011386 Amidohydrolase; Region: Amidohydro_4; pfam13147 290340011387 active site 290340011388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290340011389 E3 interaction surface; other site 290340011390 lipoyl attachment site [posttranslational modification]; other site 290340011391 e3 binding domain; Region: E3_binding; pfam02817 290340011392 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290340011393 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290340011394 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290340011395 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290340011396 alpha subunit interface [polypeptide binding]; other site 290340011397 TPP binding site [chemical binding]; other site 290340011398 heterodimer interface [polypeptide binding]; other site 290340011399 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340011400 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290340011401 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290340011402 tetramer interface [polypeptide binding]; other site 290340011403 TPP-binding site [chemical binding]; other site 290340011404 heterodimer interface [polypeptide binding]; other site 290340011405 phosphorylation loop region [posttranslational modification] 290340011406 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 290340011407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340011408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011409 homodimer interface [polypeptide binding]; other site 290340011410 catalytic residue [active] 290340011411 Membrane protein of unknown function; Region: DUF360; pfam04020 290340011412 adenylosuccinate lyase; Provisional; Region: PRK09285 290340011413 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 290340011414 tetramer interface [polypeptide binding]; other site 290340011415 active site 290340011416 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340011417 catalytic core [active] 290340011418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290340011419 Coenzyme A binding pocket [chemical binding]; other site 290340011420 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340011421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011422 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011423 putative substrate translocation pore; other site 290340011424 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 290340011425 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290340011426 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290340011427 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 290340011428 putative active site [active] 290340011429 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 290340011430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340011431 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 290340011432 putative dimerization interface [polypeptide binding]; other site 290340011433 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340011434 aspartate aminotransferase; Provisional; Region: PRK06107 290340011435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290340011436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011437 homodimer interface [polypeptide binding]; other site 290340011438 catalytic residue [active] 290340011439 SnoaL-like domain; Region: SnoaL_2; pfam12680 290340011440 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290340011441 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340011442 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 290340011443 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 290340011444 NAD binding site [chemical binding]; other site 290340011445 catalytic residues [active] 290340011446 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340011447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011448 DNA-binding site [nucleotide binding]; DNA binding site 290340011449 FCD domain; Region: FCD; pfam07729 290340011450 hypothetical protein; Provisional; Region: PRK12764 290340011451 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340011452 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340011453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 290340011454 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290340011455 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011456 CsbD-like; Region: CsbD; pfam05532 290340011457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340011458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290340011459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340011460 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 290340011461 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 290340011462 Isochorismatase family; Region: Isochorismatase; pfam00857 290340011463 catalytic triad [active] 290340011464 conserved cis-peptide bond; other site 290340011465 short chain dehydrogenase; Provisional; Region: PRK06701 290340011466 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290340011467 NAD binding site [chemical binding]; other site 290340011468 metal binding site [ion binding]; metal-binding site 290340011469 active site 290340011470 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340011471 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340011472 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290340011473 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 290340011474 Asp23 family; Region: Asp23; pfam03780 290340011475 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290340011476 RNA polymerase sigma factor; Reviewed; Region: PRK12527 290340011477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290340011478 DNA binding residues [nucleotide binding] 290340011479 Asp23 family; Region: Asp23; cl00574 290340011480 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340011481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011482 DNA-binding site [nucleotide binding]; DNA binding site 290340011483 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340011484 dimerization interface [polypeptide binding]; other site 290340011485 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290340011486 ligand binding site [chemical binding]; other site 290340011487 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340011488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340011489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011490 dimer interface [polypeptide binding]; other site 290340011491 conserved gate region; other site 290340011492 putative PBP binding loops; other site 290340011493 ABC-ATPase subunit interface; other site 290340011494 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340011495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011496 dimer interface [polypeptide binding]; other site 290340011497 conserved gate region; other site 290340011498 putative PBP binding loops; other site 290340011499 ABC-ATPase subunit interface; other site 290340011500 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 290340011501 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340011502 putative ligand binding site [chemical binding]; other site 290340011503 putative NAD binding site [chemical binding]; other site 290340011504 catalytic site [active] 290340011505 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340011506 GAF domain; Region: GAF; pfam01590 290340011507 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290340011508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290340011509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290340011510 dimer interface [polypeptide binding]; other site 290340011511 phosphorylation site [posttranslational modification] 290340011512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290340011513 ATP binding site [chemical binding]; other site 290340011514 Mg2+ binding site [ion binding]; other site 290340011515 G-X-G motif; other site 290340011516 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 290340011517 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290340011518 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340011519 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340011520 active site 290340011521 ATP binding site [chemical binding]; other site 290340011522 substrate binding site [chemical binding]; other site 290340011523 activation loop (A-loop); other site 290340011524 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290340011525 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290340011526 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340011527 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340011528 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340011529 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340011530 active site 290340011531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340011532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340011533 catalytic core [active] 290340011534 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340011535 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340011536 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290340011537 NmrA-like family; Region: NmrA; pfam05368 290340011538 NAD(P) binding site [chemical binding]; other site 290340011539 putative active site [active] 290340011540 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290340011541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340011542 non-specific DNA binding site [nucleotide binding]; other site 290340011543 salt bridge; other site 290340011544 sequence-specific DNA binding site [nucleotide binding]; other site 290340011545 Cupin domain; Region: Cupin_2; pfam07883 290340011546 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 290340011547 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290340011548 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290340011549 inhibitor site; inhibition site 290340011550 active site 290340011551 dimer interface [polypeptide binding]; other site 290340011552 catalytic residue [active] 290340011553 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290340011554 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 290340011555 putative NAD(P) binding site [chemical binding]; other site 290340011556 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290340011557 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290340011558 PRC-barrel domain; Region: PRC; pfam05239 290340011559 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 290340011560 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 290340011561 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 290340011562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011563 catalytic residue [active] 290340011564 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 290340011565 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 290340011566 putative active site [active] 290340011567 putative dimer interface [polypeptide binding]; other site 290340011568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011569 putative substrate translocation pore; other site 290340011570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340011572 salt bridge; other site 290340011573 non-specific DNA binding site [nucleotide binding]; other site 290340011574 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290340011575 sequence-specific DNA binding site [nucleotide binding]; other site 290340011576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340011577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290340011578 active site 290340011579 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290340011580 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340011581 DNA binding residues [nucleotide binding] 290340011582 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290340011583 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290340011584 active site 290340011585 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 290340011586 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290340011587 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011588 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340011589 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011590 benzoate transport; Region: 2A0115; TIGR00895 290340011591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011592 putative substrate translocation pore; other site 290340011593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011594 Hpt domain; Region: Hpt; pfam01627 290340011595 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290340011596 Catalytic site [active] 290340011597 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290340011598 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340011599 Short C-terminal domain; Region: SHOCT; pfam09851 290340011600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290340011601 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290340011602 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290340011603 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290340011604 putative active site [active] 290340011605 catalytic site [active] 290340011606 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290340011607 putative active site [active] 290340011608 catalytic site [active] 290340011609 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290340011610 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290340011611 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 290340011612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011614 DNA binding residues [nucleotide binding] 290340011615 dimerization interface [polypeptide binding]; other site 290340011616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290340011617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290340011618 active site 290340011619 ATP binding site [chemical binding]; other site 290340011620 substrate binding site [chemical binding]; other site 290340011621 activation loop (A-loop); other site 290340011622 MarR family; Region: MarR; pfam01047 290340011623 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290340011624 lipoyl synthase; Provisional; Region: PRK05481 290340011625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290340011626 FeS/SAM binding site; other site 290340011627 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290340011628 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290340011629 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290340011630 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290340011631 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290340011632 dimer interface [polypeptide binding]; other site 290340011633 active site 290340011634 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290340011635 folate binding site [chemical binding]; other site 290340011636 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290340011637 lipoyl attachment site [posttranslational modification]; other site 290340011638 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290340011639 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290340011640 glycine dehydrogenase; Provisional; Region: PRK05367 290340011641 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340011642 tetramer interface [polypeptide binding]; other site 290340011643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011644 catalytic residue [active] 290340011645 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290340011646 tetramer interface [polypeptide binding]; other site 290340011647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340011648 catalytic residue [active] 290340011649 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290340011650 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340011651 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 290340011652 agmatinase; Region: agmatinase; TIGR01230 290340011653 oligomer interface [polypeptide binding]; other site 290340011654 putative active site [active] 290340011655 Mn binding site [ion binding]; other site 290340011656 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290340011657 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290340011658 Na binding site [ion binding]; other site 290340011659 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290340011660 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290340011661 tetrameric interface [polypeptide binding]; other site 290340011662 NAD binding site [chemical binding]; other site 290340011663 catalytic residues [active] 290340011664 substrate binding site [chemical binding]; other site 290340011665 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 290340011666 FAD binding domain; Region: FAD_binding_4; pfam01565 290340011667 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 290340011668 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 290340011669 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290340011670 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290340011671 RibD C-terminal domain; Region: RibD_C; cl17279 290340011672 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290340011673 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290340011674 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 290340011675 Predicted flavoprotein [General function prediction only]; Region: COG0431 290340011676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290340011677 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290340011678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340011679 motif II; other site 290340011680 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 290340011681 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 290340011682 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340011683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290340011684 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290340011685 PaaX-like protein; Region: PaaX; pfam07848 290340011686 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 290340011687 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290340011688 active site 290340011689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340011690 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290340011691 acyl-activating enzyme (AAE) consensus motif; other site 290340011692 AMP binding site [chemical binding]; other site 290340011693 active site 290340011694 CoA binding site [chemical binding]; other site 290340011695 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 290340011696 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290340011697 active site 290340011698 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290340011699 catalytic triad [active] 290340011700 dimer interface [polypeptide binding]; other site 290340011701 Cupin domain; Region: Cupin_2; cl17218 290340011702 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290340011703 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340011704 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340011705 homotrimer interaction site [polypeptide binding]; other site 290340011706 putative active site [active] 290340011707 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290340011708 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290340011709 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340011710 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011711 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290340011712 Coenzyme A transferase; Region: CoA_trans; cl17247 290340011713 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 290340011714 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290340011715 dimer interface [polypeptide binding]; other site 290340011716 active site 290340011717 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 290340011718 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 290340011719 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 290340011720 tetramer interface [polypeptide binding]; other site 290340011721 active site 290340011722 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 290340011723 heterodimer interface [polypeptide binding]; other site 290340011724 active site 290340011725 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 290340011726 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 290340011727 active site 290340011728 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340011729 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 290340011730 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 290340011731 dimer interface [polypeptide binding]; other site 290340011732 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 290340011733 active site 290340011734 Fe binding site [ion binding]; other site 290340011735 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 290340011736 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290340011737 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290340011738 shikimate binding site; other site 290340011739 NAD(P) binding site [chemical binding]; other site 290340011740 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011741 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340011742 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011744 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011745 putative substrate translocation pore; other site 290340011746 Family description; Region: VCBS; pfam13517 290340011747 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011748 Family description; Region: VCBS; pfam13517 290340011749 Family description; Region: VCBS; pfam13517 290340011750 Family description; Region: VCBS; pfam13517 290340011751 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011752 Family description; Region: VCBS; pfam13517 290340011753 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011754 Family description; Region: VCBS; pfam13517 290340011755 FG-GAP repeat; Region: FG-GAP; pfam01839 290340011756 Family description; Region: VCBS; pfam13517 290340011757 Ubiquitin-like proteins; Region: UBQ; cl00155 290340011758 charged pocket; other site 290340011759 hydrophobic patch; other site 290340011760 VPS10 domain; Region: VPS10; smart00602 290340011761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340011762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340011763 metal binding site [ion binding]; metal-binding site 290340011764 active site 290340011765 I-site; other site 290340011766 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340011767 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340011768 tetramer interface [polypeptide binding]; other site 290340011769 active site 290340011770 Mg2+/Mn2+ binding site [ion binding]; other site 290340011771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290340011772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290340011773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290340011774 dimerization interface [polypeptide binding]; other site 290340011775 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290340011776 Ligand Binding Site [chemical binding]; other site 290340011777 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290340011778 GntP family permease; Region: GntP_permease; pfam02447 290340011779 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 290340011780 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290340011781 active site 290340011782 intersubunit interface [polypeptide binding]; other site 290340011783 catalytic residue [active] 290340011784 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 290340011785 Amidohydrolase family; Region: Amidohydro_3; pfam07969 290340011786 active site 290340011787 putative substrate binding pocket [chemical binding]; other site 290340011788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340011789 active site 290340011790 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 290340011791 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 290340011792 dimer interface [polypeptide binding]; other site 290340011793 active site 290340011794 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290340011795 substrate binding site [chemical binding]; other site 290340011796 catalytic residue [active] 290340011797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340011798 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290340011799 substrate binding site [chemical binding]; other site 290340011800 ATP binding site [chemical binding]; other site 290340011801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011802 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340011803 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011804 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290340011805 homotrimer interaction site [polypeptide binding]; other site 290340011806 putative active site [active] 290340011807 Predicted permeases [General function prediction only]; Region: COG0679 290340011808 LssY C-terminus; Region: LssY_C; pfam14067 290340011809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011810 NAD(P) binding site [chemical binding]; other site 290340011811 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290340011812 active site 290340011813 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 290340011814 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340011815 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340011816 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 290340011817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340011818 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340011819 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290340011820 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290340011821 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290340011822 putative active site [active] 290340011823 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 290340011824 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340011825 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290340011826 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340011827 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290340011828 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290340011829 putative active site [active] 290340011830 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 290340011831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340011832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340011833 DNA binding site [nucleotide binding] 290340011834 domain linker motif; other site 290340011835 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 290340011836 putative dimerization interface [polypeptide binding]; other site 290340011837 putative ligand binding site [chemical binding]; other site 290340011838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340011839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011840 dimer interface [polypeptide binding]; other site 290340011841 conserved gate region; other site 290340011842 putative PBP binding loops; other site 290340011843 ABC-ATPase subunit interface; other site 290340011844 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340011845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011846 dimer interface [polypeptide binding]; other site 290340011847 conserved gate region; other site 290340011848 putative PBP binding loops; other site 290340011849 ABC-ATPase subunit interface; other site 290340011850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340011851 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340011852 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290340011853 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 290340011854 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290340011855 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290340011856 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 290340011857 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290340011858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340011859 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 290340011860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290340011861 active site residue [active] 290340011862 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340011863 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340011864 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340011865 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 290340011866 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 290340011867 active site 290340011868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340011869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011870 dimer interface [polypeptide binding]; other site 290340011871 conserved gate region; other site 290340011872 putative PBP binding loops; other site 290340011873 ABC-ATPase subunit interface; other site 290340011874 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290340011875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340011876 dimer interface [polypeptide binding]; other site 290340011877 conserved gate region; other site 290340011878 putative PBP binding loops; other site 290340011879 ABC-ATPase subunit interface; other site 290340011880 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340011881 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290340011882 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340011883 putative homodimer interface [polypeptide binding]; other site 290340011884 putative homotetramer interface [polypeptide binding]; other site 290340011885 putative allosteric switch controlling residues; other site 290340011886 putative metal binding site [ion binding]; other site 290340011887 putative homodimer-homodimer interface [polypeptide binding]; other site 290340011888 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340011889 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340011890 metal-binding site [ion binding] 290340011891 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340011892 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290340011893 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 290340011894 EamA-like transporter family; Region: EamA; pfam00892 290340011895 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290340011896 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 290340011897 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 290340011898 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 290340011899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 290340011900 Predicted membrane protein [Function unknown]; Region: COG2259 290340011901 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290340011902 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340011903 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290340011904 AAA domain; Region: AAA_22; pfam13401 290340011905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011906 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340011907 DNA binding residues [nucleotide binding] 290340011908 dimerization interface [polypeptide binding]; other site 290340011909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340011910 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290340011911 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290340011912 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 290340011913 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 290340011914 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 290340011915 NADP binding site [chemical binding]; other site 290340011916 active site 290340011917 putative substrate binding site [chemical binding]; other site 290340011918 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 290340011919 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 290340011920 NADP-binding site; other site 290340011921 homotetramer interface [polypeptide binding]; other site 290340011922 substrate binding site [chemical binding]; other site 290340011923 homodimer interface [polypeptide binding]; other site 290340011924 active site 290340011925 putative glycosyl transferase; Provisional; Region: PRK10307 290340011926 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 290340011927 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 290340011928 putative trimer interface [polypeptide binding]; other site 290340011929 putative active site [active] 290340011930 putative substrate binding site [chemical binding]; other site 290340011931 putative CoA binding site [chemical binding]; other site 290340011932 O-Antigen ligase; Region: Wzy_C; cl04850 290340011933 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290340011934 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290340011935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340011936 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290340011937 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290340011938 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 290340011939 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340011940 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 290340011941 putative ADP-binding pocket [chemical binding]; other site 290340011942 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 290340011943 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290340011944 Chain length determinant protein; Region: Wzz; cl15801 290340011945 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290340011946 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340011947 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290340011948 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290340011949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290340011950 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340011951 Walker A motif; other site 290340011952 ATP binding site [chemical binding]; other site 290340011953 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340011954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340011955 DNA-binding site [nucleotide binding]; DNA binding site 290340011956 FCD domain; Region: FCD; pfam07729 290340011957 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290340011958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290340011959 PYR/PP interface [polypeptide binding]; other site 290340011960 dimer interface [polypeptide binding]; other site 290340011961 TPP binding site [chemical binding]; other site 290340011962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290340011963 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290340011964 TPP-binding site [chemical binding]; other site 290340011965 dimer interface [polypeptide binding]; other site 290340011966 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340011967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340011968 putative substrate translocation pore; other site 290340011969 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290340011970 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290340011971 Metal-binding active site; metal-binding site 290340011972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340011973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340011974 NAD(P) binding site [chemical binding]; other site 290340011975 active site 290340011976 dihydroxyacetone kinase; Provisional; Region: PRK14479 290340011977 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290340011978 DAK2 domain; Region: Dak2; pfam02734 290340011979 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 290340011980 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 290340011981 replicative DNA helicase; Region: DnaB; TIGR00665 290340011982 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290340011983 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290340011984 Walker A motif; other site 290340011985 ATP binding site [chemical binding]; other site 290340011986 Walker B motif; other site 290340011987 DNA binding loops [nucleotide binding] 290340011988 hypothetical protein; Provisional; Region: PRK06771 290340011989 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 290340011990 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290340011991 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 290340011992 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290340011993 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290340011994 substrate binding pocket [chemical binding]; other site 290340011995 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290340011996 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290340011997 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290340011998 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290340011999 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 290340012000 active site 290340012001 catalytic residues [active] 290340012002 metal binding site [ion binding]; metal-binding site 290340012003 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290340012004 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 290340012005 dimerization interface [polypeptide binding]; other site 290340012006 ligand binding site [chemical binding]; other site 290340012007 NADP binding site [chemical binding]; other site 290340012008 catalytic site [active] 290340012009 Glycerate kinase family; Region: Gly_kinase; cl00841 290340012010 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290340012011 hydrophobic ligand binding site; other site 290340012012 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 290340012013 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340012014 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340012015 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 290340012016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340012017 S-adenosylmethionine binding site [chemical binding]; other site 290340012018 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340012019 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290340012020 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012021 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290340012022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340012023 Walker A/P-loop; other site 290340012024 ATP binding site [chemical binding]; other site 290340012025 Q-loop/lid; other site 290340012026 Walker B; other site 290340012027 D-loop; other site 290340012028 H-loop/switch region; other site 290340012029 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 290340012030 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 290340012031 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290340012032 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290340012033 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290340012034 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290340012035 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 290340012036 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290340012037 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340012038 dimer interface [polypeptide binding]; other site 290340012039 ssDNA binding site [nucleotide binding]; other site 290340012040 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340012041 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 290340012042 hypothetical protein; Provisional; Region: PRK02237 290340012043 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290340012044 Spore germination protein; Region: Spore_permease; cl17796 290340012045 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 290340012046 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 290340012047 active site 290340012048 metal binding site [ion binding]; metal-binding site 290340012049 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 290340012050 putative active site [active] 290340012051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340012052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340012053 active site 290340012054 phosphorylation site [posttranslational modification] 290340012055 intermolecular recognition site; other site 290340012056 dimerization interface [polypeptide binding]; other site 290340012057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340012058 DNA binding residues [nucleotide binding] 290340012059 dimerization interface [polypeptide binding]; other site 290340012060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340012061 Histidine kinase; Region: HisKA_3; pfam07730 290340012062 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 290340012063 ATP binding site [chemical binding]; other site 290340012064 Mg2+ binding site [ion binding]; other site 290340012065 G-X-G motif; other site 290340012066 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 290340012067 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 290340012068 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290340012069 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 290340012070 Walker A/P-loop; other site 290340012071 ATP binding site [chemical binding]; other site 290340012072 Q-loop/lid; other site 290340012073 ABC transporter signature motif; other site 290340012074 Walker B; other site 290340012075 D-loop; other site 290340012076 H-loop/switch region; other site 290340012077 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290340012078 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290340012079 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290340012080 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290340012081 active site 290340012082 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290340012083 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290340012084 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290340012085 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290340012086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340012087 Walker A/P-loop; other site 290340012088 ATP binding site [chemical binding]; other site 290340012089 Q-loop/lid; other site 290340012090 ABC transporter signature motif; other site 290340012091 Walker B; other site 290340012092 D-loop; other site 290340012093 H-loop/switch region; other site 290340012094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290340012095 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290340012096 Beta-lactamase; Region: Beta-lactamase; pfam00144 290340012097 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 290340012098 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 290340012099 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290340012100 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290340012101 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290340012102 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 290340012103 putative active site [active] 290340012104 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 290340012105 putative catalytic site [active] 290340012106 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290340012107 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 290340012108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290340012109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340012110 active site 290340012111 phosphorylation site [posttranslational modification] 290340012112 intermolecular recognition site; other site 290340012113 dimerization interface [polypeptide binding]; other site 290340012114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290340012115 DNA binding residues [nucleotide binding] 290340012116 dimerization interface [polypeptide binding]; other site 290340012117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290340012118 Histidine kinase; Region: HisKA_3; pfam07730 290340012119 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 290340012120 ATP binding site [chemical binding]; other site 290340012121 G-X-G motif; other site 290340012122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290340012123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290340012124 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290340012125 Walker A/P-loop; other site 290340012126 ATP binding site [chemical binding]; other site 290340012127 Q-loop/lid; other site 290340012128 ABC transporter signature motif; other site 290340012129 Walker B; other site 290340012130 D-loop; other site 290340012131 H-loop/switch region; other site 290340012132 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340012133 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290340012134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012135 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290340012136 NAD(P) binding site [chemical binding]; other site 290340012137 active site 290340012138 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290340012139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340012140 Predicted integral membrane protein [Function unknown]; Region: COG5650 290340012141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290340012142 catalytic core [active] 290340012143 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290340012144 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 290340012145 active site 290340012146 NTP binding site [chemical binding]; other site 290340012147 metal binding triad [ion binding]; metal-binding site 290340012148 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290340012149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290340012150 Zn2+ binding site [ion binding]; other site 290340012151 Mg2+ binding site [ion binding]; other site 290340012152 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 290340012153 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290340012154 active site 290340012155 Ap6A binding site [chemical binding]; other site 290340012156 nudix motif; other site 290340012157 metal binding site [ion binding]; metal-binding site 290340012158 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 290340012159 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340012160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340012161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012162 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 290340012163 ParB-like nuclease domain; Region: ParBc; pfam02195 290340012164 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340012165 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012166 P-loop; other site 290340012167 Magnesium ion binding site [ion binding]; other site 290340012168 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012169 Magnesium ion binding site [ion binding]; other site 290340012170 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 290340012171 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 290340012172 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 290340012173 G-X-X-G motif; other site 290340012174 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 290340012175 RxxxH motif; other site 290340012176 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 290340012177 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290340012178 Haemolytic domain; Region: Haemolytic; pfam01809 290340012179 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 290340012180 AAA domain; Region: AAA_31; pfam13614 290340012181 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340012182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012183 Magnesium ion binding site [ion binding]; other site 290340012184 AAA ATPase domain; Region: AAA_16; pfam13191 290340012185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012186 dimerization interface [polypeptide binding]; other site 290340012187 putative DNA binding site [nucleotide binding]; other site 290340012188 putative Zn2+ binding site [ion binding]; other site 290340012189 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290340012190 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290340012191 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 290340012192 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290340012193 ATP binding site [chemical binding]; other site 290340012194 Walker A motif; other site 290340012195 hexamer interface [polypeptide binding]; other site 290340012196 Walker B motif; other site 290340012197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340012198 AAA-like domain; Region: AAA_10; pfam12846 290340012199 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290340012200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340012201 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290340012202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340012203 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 290340012204 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290340012205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340012206 active site 290340012207 DNA binding site [nucleotide binding] 290340012208 Int/Topo IB signature motif; other site 290340012209 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340012210 putative catalytic site [active] 290340012211 putative metal binding site [ion binding]; other site 290340012212 putative phosphate binding site [ion binding]; other site 290340012213 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290340012214 putative catalytic site [active] 290340012215 putative metal binding site [ion binding]; other site 290340012216 putative phosphate binding site [ion binding]; other site 290340012217 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290340012218 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290340012219 catalytic residue [active] 290340012220 AAA domain; Region: AAA_22; pfam13401 290340012221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290340012222 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 290340012223 Walker A/P-loop; other site 290340012224 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290340012225 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290340012226 DnaA box-binding interface [nucleotide binding]; other site 290340012227 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 290340012228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340012229 active site 290340012230 Int/Topo IB signature motif; other site 290340012231 DNA binding site [nucleotide binding] 290340012232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340012233 active site 290340012234 Int/Topo IB signature motif; other site 290340012235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340012236 non-specific DNA binding site [nucleotide binding]; other site 290340012237 salt bridge; other site 290340012238 sequence-specific DNA binding site [nucleotide binding]; other site 290340012239 Creatinine amidohydrolase; Region: Creatininase; pfam02633 290340012240 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 290340012241 transposase; Provisional; Region: PRK06526 290340012242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340012243 Walker A motif; other site 290340012244 ATP binding site [chemical binding]; other site 290340012245 Walker B motif; other site 290340012246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290340012247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 290340012248 Integrase core domain; Region: rve; pfam00665 290340012249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290340012250 Epoxide hydrolase N terminus; Region: EHN; pfam06441 290340012251 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290340012252 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 290340012253 amino acid transporter; Region: 2A0306; TIGR00909 290340012254 Ferredoxin [Energy production and conversion]; Region: COG1146 290340012255 4Fe-4S binding domain; Region: Fer4; pfam00037 290340012256 ferredoxin-NADP+ reductase; Region: PLN02852 290340012257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290340012258 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 290340012259 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340012260 NAD binding site [chemical binding]; other site 290340012261 catalytic Zn binding site [ion binding]; other site 290340012262 substrate binding site [chemical binding]; other site 290340012263 structural Zn binding site [ion binding]; other site 290340012264 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340012265 active site 2 [active] 290340012266 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 290340012267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340012268 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 290340012269 acyl-activating enzyme (AAE) consensus motif; other site 290340012270 acyl-activating enzyme (AAE) consensus motif; other site 290340012271 putative AMP binding site [chemical binding]; other site 290340012272 putative active site [active] 290340012273 putative CoA binding site [chemical binding]; other site 290340012274 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290340012275 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 290340012276 NAD(P) binding site [chemical binding]; other site 290340012277 catalytic residues [active] 290340012278 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340012279 catalytic triad [active] 290340012280 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340012281 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012282 NAD(P) binding site [chemical binding]; other site 290340012283 catalytic residues [active] 290340012284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290340012285 classical (c) SDRs; Region: SDR_c; cd05233 290340012286 NAD(P) binding site [chemical binding]; other site 290340012287 active site 290340012288 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340012289 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340012290 catalytic triad [active] 290340012291 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290340012292 Cytochrome P450; Region: p450; cl12078 290340012293 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 290340012294 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 290340012295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290340012296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012297 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340012298 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340012299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340012300 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290340012301 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340012302 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290340012303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012304 putative DNA binding site [nucleotide binding]; other site 290340012305 putative Zn2+ binding site [ion binding]; other site 290340012306 AsnC family; Region: AsnC_trans_reg; pfam01037 290340012307 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340012308 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290340012309 hexamer interface [polypeptide binding]; other site 290340012310 ligand binding site [chemical binding]; other site 290340012311 putative active site [active] 290340012312 NAD(P) binding site [chemical binding]; other site 290340012313 pyruvate carboxylase; Reviewed; Region: PRK12999 290340012314 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290340012315 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290340012316 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290340012317 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290340012318 active site 290340012319 catalytic residues [active] 290340012320 metal binding site [ion binding]; metal-binding site 290340012321 homodimer binding site [polypeptide binding]; other site 290340012322 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290340012323 carboxyltransferase (CT) interaction site; other site 290340012324 biotinylation site [posttranslational modification]; other site 290340012325 Transcription factor WhiB; Region: Whib; pfam02467 290340012326 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340012327 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340012328 active site 290340012329 metal binding site [ion binding]; metal-binding site 290340012330 interdomain interaction site; other site 290340012331 TrwC relaxase; Region: TrwC; pfam08751 290340012332 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340012333 AAA domain; Region: AAA_22; pfam13401 290340012334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340012335 Walker A motif; other site 290340012336 ATP binding site [chemical binding]; other site 290340012337 Walker B motif; other site 290340012338 NACHT domain; Region: NACHT; pfam05729 290340012339 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340012340 AAA domain; Region: AAA_30; pfam13604 290340012341 Family description; Region: UvrD_C_2; pfam13538 290340012342 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340012343 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340012344 active site 290340012345 metal binding site [ion binding]; metal-binding site 290340012346 interdomain interaction site; other site 290340012347 Staphylococcal nuclease homologues; Region: SNc; smart00318 290340012348 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 290340012349 Catalytic site; other site 290340012350 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340012351 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340012352 active site 290340012353 putative substrate binding pocket [chemical binding]; other site 290340012354 NACHT domain; Region: NACHT; pfam05729 290340012355 AAA domain; Region: AAA_30; pfam13604 290340012356 Family description; Region: UvrD_C_2; pfam13538 290340012357 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290340012358 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290340012359 active site 290340012360 metal binding site [ion binding]; metal-binding site 290340012361 interdomain interaction site; other site 290340012362 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340012363 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340012364 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012365 Magnesium ion binding site [ion binding]; other site 290340012366 MarR family; Region: MarR_2; pfam12802 290340012367 HTH-like domain; Region: HTH_21; pfam13276 290340012368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340012369 Integrase core domain; Region: rve; pfam00665 290340012370 Integrase core domain; Region: rve_3; pfam13683 290340012371 Transposase; Region: HTH_Tnp_1; pfam01527 290340012372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290340012373 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340012374 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340012375 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 290340012376 AAA-like domain; Region: AAA_10; pfam12846 290340012377 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 290340012378 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290340012379 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 290340012380 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 290340012381 HicB family; Region: HicB; pfam05534 290340012382 TrwC relaxase; Region: TrwC; pfam08751 290340012383 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 290340012384 AAA domain; Region: AAA_30; pfam13604 290340012385 Family description; Region: UvrD_C_2; pfam13538 290340012386 ParB-like nuclease domain; Region: ParBc; pfam02195 290340012387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290340012388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290340012389 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290340012390 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 290340012391 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290340012392 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 290340012393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012394 dimerization interface [polypeptide binding]; other site 290340012395 putative DNA binding site [nucleotide binding]; other site 290340012396 putative Zn2+ binding site [ion binding]; other site 290340012397 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340012398 metal-binding site [ion binding] 290340012399 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340012400 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340012401 metal-binding site [ion binding] 290340012402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012403 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290340012404 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 290340012405 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340012406 putative homodimer interface [polypeptide binding]; other site 290340012407 putative homotetramer interface [polypeptide binding]; other site 290340012408 putative allosteric switch controlling residues; other site 290340012409 putative metal binding site [ion binding]; other site 290340012410 putative homodimer-homodimer interface [polypeptide binding]; other site 290340012411 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290340012412 dimerization interface [polypeptide binding]; other site 290340012413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340012414 metal-binding site [ion binding] 290340012415 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340012416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340012418 motif II; other site 290340012419 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290340012420 Ycf48-like protein; Provisional; Region: PRK13684 290340012421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290340012422 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290340012423 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340012424 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340012425 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340012426 catalytic residues [active] 290340012427 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290340012428 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290340012429 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290340012430 NlpC/P60 family; Region: NLPC_P60; cl17555 290340012431 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290340012432 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 290340012433 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290340012434 acyl-activating enzyme (AAE) consensus motif; other site 290340012435 AMP binding site [chemical binding]; other site 290340012436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290340012437 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 290340012438 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340012439 putative trimer interface [polypeptide binding]; other site 290340012440 putative CoA binding site [chemical binding]; other site 290340012441 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290340012442 putative trimer interface [polypeptide binding]; other site 290340012443 putative CoA binding site [chemical binding]; other site 290340012444 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 290340012445 active site 290340012446 active site 290340012447 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 290340012448 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290340012449 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290340012450 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 290340012451 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290340012452 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 290340012453 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290340012454 ResB-like family; Region: ResB; pfam05140 290340012455 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340012456 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340012457 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340012458 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 290340012459 Subunit I/III interface [polypeptide binding]; other site 290340012460 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340012461 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290340012462 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290340012463 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290340012464 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 290340012465 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 290340012466 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290340012467 putative active site [active] 290340012468 putative metal binding site [ion binding]; other site 290340012469 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290340012470 lipoprotein signal peptidase; Provisional; Region: PRK14781 290340012471 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290340012472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340012474 motif II; other site 290340012475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012476 dimerization interface [polypeptide binding]; other site 290340012477 putative DNA binding site [nucleotide binding]; other site 290340012478 putative Zn2+ binding site [ion binding]; other site 290340012479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012480 dimerization interface [polypeptide binding]; other site 290340012481 putative DNA binding site [nucleotide binding]; other site 290340012482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290340012483 putative Zn2+ binding site [ion binding]; other site 290340012484 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290340012485 Thioredoxin; Region: Thioredoxin_4; pfam13462 290340012486 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340012487 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290340012488 Copper resistance protein D; Region: CopD; cl00563 290340012489 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290340012490 CopC domain; Region: CopC; pfam04234 290340012491 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290340012492 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340012493 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340012494 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340012495 catalytic residues [active] 290340012496 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 290340012497 putative active site [active] 290340012498 redox center [active] 290340012499 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290340012500 PASTA domain; Region: PASTA; pfam03793 290340012501 Peptidase C26; Region: Peptidase_C26; pfam07722 290340012502 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340012503 catalytic triad [active] 290340012504 Water Stress and Hypersensitive response; Region: WHy; smart00769 290340012505 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 290340012506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340012507 active site 290340012508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340012510 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290340012511 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290340012512 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290340012513 Transposase domain (DUF772); Region: DUF772; pfam05598 290340012514 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 290340012515 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 290340012516 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290340012517 cytosine deaminase; Provisional; Region: PRK05985 290340012518 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290340012519 active site 290340012520 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 290340012521 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 290340012522 putative substrate binding site [chemical binding]; other site 290340012523 nucleotide binding site [chemical binding]; other site 290340012524 nucleotide binding site [chemical binding]; other site 290340012525 homodimer interface [polypeptide binding]; other site 290340012526 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 290340012527 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290340012528 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290340012529 active site 290340012530 putative substrate binding pocket [chemical binding]; other site 290340012531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340012533 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290340012534 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 290340012535 Putative transposase; Region: Y2_Tnp; pfam04986 290340012536 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290340012537 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290340012538 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290340012539 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012540 catalytic residues [active] 290340012541 catalytic nucleophile [active] 290340012542 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012543 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012544 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012545 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012546 DNA binding site [nucleotide binding] 290340012547 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340012548 DNA-binding interface [nucleotide binding]; DNA binding site 290340012549 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290340012550 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290340012551 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290340012552 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290340012553 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290340012554 Short C-terminal domain; Region: SHOCT; pfam09851 290340012555 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290340012556 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340012557 active site residue [active] 290340012558 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290340012559 catalytic residues [active] 290340012560 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340012561 active site residue [active] 290340012562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340012563 active site residue [active] 290340012564 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340012565 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340012566 active site residue [active] 290340012567 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290340012568 putative homodimer interface [polypeptide binding]; other site 290340012569 putative homotetramer interface [polypeptide binding]; other site 290340012570 putative allosteric switch controlling residues; other site 290340012571 putative metal binding site [ion binding]; other site 290340012572 putative homodimer-homodimer interface [polypeptide binding]; other site 290340012573 Domain of unknown function DUF302; Region: DUF302; pfam03625 290340012574 DsrE/DsrF-like family; Region: DrsE; pfam02635 290340012575 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290340012576 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290340012577 DNA binding residues [nucleotide binding] 290340012578 dimer interface [polypeptide binding]; other site 290340012579 metal binding site [ion binding]; metal-binding site 290340012580 mercuric reductase; Region: MerA; TIGR02053 290340012581 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012582 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290340012583 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012584 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012585 catalytic residues [active] 290340012586 catalytic nucleophile [active] 290340012587 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012588 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012589 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012590 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012591 DNA binding site [nucleotide binding] 290340012592 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340012593 DNA-binding interface [nucleotide binding]; DNA binding site 290340012594 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012595 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012596 catalytic residues [active] 290340012597 catalytic nucleophile [active] 290340012598 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012599 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012600 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012601 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012602 DNA binding site [nucleotide binding] 290340012603 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340012604 DNA-binding interface [nucleotide binding]; DNA binding site 290340012605 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 290340012606 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290340012607 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290340012608 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290340012609 Walker A/P-loop; other site 290340012610 ATP binding site [chemical binding]; other site 290340012611 Q-loop/lid; other site 290340012612 ABC transporter signature motif; other site 290340012613 Walker B; other site 290340012614 D-loop; other site 290340012615 H-loop/switch region; other site 290340012616 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340012617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290340012618 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290340012619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340012620 dimer interface [polypeptide binding]; other site 290340012621 conserved gate region; other site 290340012622 putative PBP binding loops; other site 290340012623 ABC-ATPase subunit interface; other site 290340012624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290340012625 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 290340012626 catalytic loop [active] 290340012627 iron binding site [ion binding]; other site 290340012628 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 290340012629 FAD binding pocket [chemical binding]; other site 290340012630 FAD binding motif [chemical binding]; other site 290340012631 phosphate binding motif [ion binding]; other site 290340012632 beta-alpha-beta structure motif; other site 290340012633 NAD binding pocket [chemical binding]; other site 290340012634 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290340012635 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 290340012636 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290340012637 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290340012638 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290340012639 iron-sulfur cluster [ion binding]; other site 290340012640 [2Fe-2S] cluster binding site [ion binding]; other site 290340012641 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 290340012642 putative alpha subunit interface [polypeptide binding]; other site 290340012643 putative active site [active] 290340012644 putative substrate binding site [chemical binding]; other site 290340012645 Fe binding site [ion binding]; other site 290340012646 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290340012647 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290340012648 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012649 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340012650 Amidase; Region: Amidase; pfam01425 290340012651 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290340012652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290340012653 membrane-bound complex binding site; other site 290340012654 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 290340012655 hinge residues; other site 290340012656 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 290340012657 active site 290340012658 catalytic triad [active] 290340012659 Transposase; Region: HTH_Tnp_1; pfam01527 290340012660 HTH-like domain; Region: HTH_21; pfam13276 290340012661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340012662 Integrase core domain; Region: rve; pfam00665 290340012663 Integrase core domain; Region: rve_3; pfam13683 290340012664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290340012665 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290340012666 Walker A motif; other site 290340012667 ATP binding site [chemical binding]; other site 290340012668 Walker B motif; other site 290340012669 arginine finger; other site 290340012670 Predicted helicase [General function prediction only]; Region: COG4889 290340012671 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 290340012672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340012673 ATP binding site [chemical binding]; other site 290340012674 putative Mg++ binding site [ion binding]; other site 290340012675 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290340012676 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290340012677 Lsr2; Region: Lsr2; pfam11774 290340012678 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290340012679 ThiC-associated domain; Region: ThiC-associated; pfam13667 290340012680 ThiC family; Region: ThiC; pfam01964 290340012681 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340012682 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340012683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340012684 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290340012685 Domain of unknown function DUF21; Region: DUF21; pfam01595 290340012686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290340012687 Transporter associated domain; Region: CorC_HlyC; pfam03471 290340012688 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290340012689 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290340012690 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 290340012691 AAA ATPase domain; Region: AAA_16; pfam13191 290340012692 AAA domain; Region: AAA_22; pfam13401 290340012693 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 290340012694 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290340012695 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 290340012696 PLD-like domain; Region: PLDc_2; pfam13091 290340012697 putative homodimer interface [polypeptide binding]; other site 290340012698 putative active site [active] 290340012699 catalytic site [active] 290340012700 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340012701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290340012702 ATP binding site [chemical binding]; other site 290340012703 putative Mg++ binding site [ion binding]; other site 290340012704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290340012705 ATP-binding site [chemical binding]; other site 290340012706 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 290340012707 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 290340012708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290340012709 S-adenosylmethionine binding site [chemical binding]; other site 290340012710 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290340012711 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340012712 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290340012713 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290340012714 Peptidase family M48; Region: Peptidase_M48; cl12018 290340012715 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 290340012716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290340012717 salt bridge; other site 290340012718 non-specific DNA binding site [nucleotide binding]; other site 290340012719 sequence-specific DNA binding site [nucleotide binding]; other site 290340012720 HipA N-terminal domain; Region: Couple_hipA; pfam13657 290340012721 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290340012722 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290340012723 ParA-like protein; Provisional; Region: PHA02518 290340012724 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290340012725 Magnesium ion binding site [ion binding]; other site 290340012726 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290340012727 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290340012728 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290340012729 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290340012730 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290340012731 nucleotide binding region [chemical binding]; other site 290340012732 ATP-binding site [chemical binding]; other site 290340012733 Predicted ATPase [General function prediction only]; Region: COG5293 290340012734 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 290340012735 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 290340012736 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340012737 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340012738 catalytic residues [active] 290340012739 catalytic nucleophile [active] 290340012740 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340012741 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340012742 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340012743 Synaptic Site I dimer interface [polypeptide binding]; other site 290340012744 DNA binding site [nucleotide binding] 290340012745 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 290340012746 DNA-binding interface [nucleotide binding]; DNA binding site 290340012747 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 290340012748 putative hydrophobic ligand binding site [chemical binding]; other site 290340012749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340012751 translocation protein TolB; Provisional; Region: tolB; PRK01029 290340012752 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290340012753 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012754 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340012755 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012756 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340012757 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012758 Bacterial Ig-like domain; Region: Big_5; pfam13205 290340012759 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290340012760 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290340012761 dimerization interface [polypeptide binding]; other site 290340012762 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290340012763 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 290340012764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290340012766 motif II; other site 290340012767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012768 dimerization interface [polypeptide binding]; other site 290340012769 putative DNA binding site [nucleotide binding]; other site 290340012770 putative Zn2+ binding site [ion binding]; other site 290340012771 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290340012772 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340012773 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290340012774 lipoprotein signal peptidase; Provisional; Region: PRK14781 290340012775 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290340012776 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290340012777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290340012778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290340012779 catalytic residues [active] 290340012780 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 290340012781 putative active site [active] 290340012782 redox center [active] 290340012783 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290340012784 Peptidase family M23; Region: Peptidase_M23; pfam01551 290340012785 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290340012786 ResB-like family; Region: ResB; pfam05140 290340012787 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290340012788 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290340012789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012790 putative DNA binding site [nucleotide binding]; other site 290340012791 putative Zn2+ binding site [ion binding]; other site 290340012792 Copper resistance protein D; Region: CopD; pfam05425 290340012793 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290340012794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012795 dimerization interface [polypeptide binding]; other site 290340012796 putative DNA binding site [nucleotide binding]; other site 290340012797 putative Zn2+ binding site [ion binding]; other site 290340012798 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290340012799 Thioredoxin; Region: Thioredoxin_4; cl17273 290340012800 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290340012801 CopC domain; Region: CopC; pfam04234 290340012802 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290340012803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012804 putative DNA binding site [nucleotide binding]; other site 290340012805 putative Zn2+ binding site [ion binding]; other site 290340012806 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290340012807 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 290340012808 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 290340012809 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290340012810 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290340012811 H+ Antiporter protein; Region: 2A0121; TIGR00900 290340012812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012813 dimerization interface [polypeptide binding]; other site 290340012814 putative DNA binding site [nucleotide binding]; other site 290340012815 putative Zn2+ binding site [ion binding]; other site 290340012816 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290340012817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012818 dimerization interface [polypeptide binding]; other site 290340012819 putative DNA binding site [nucleotide binding]; other site 290340012820 putative Zn2+ binding site [ion binding]; other site 290340012821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340012822 putative DNA binding site [nucleotide binding]; other site 290340012823 dimerization interface [polypeptide binding]; other site 290340012824 putative Zn2+ binding site [ion binding]; other site 290340012825 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340012826 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340012827 active site 290340012828 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340012829 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290340012830 active site 290340012831 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290340012832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340012833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340012834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290340012835 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340012836 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340012837 active site 290340012838 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290340012839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290340012840 active site 290340012841 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290340012842 DinB superfamily; Region: DinB_2; pfam12867 290340012843 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 290340012844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290340012845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290340012846 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290340012847 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 290340012848 ParB-like nuclease domain; Region: ParBc; pfam02195 290340012849 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290340012850 catalytic residues [active] 290340012851 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290340012852 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290340012853 dimer interface [polypeptide binding]; other site 290340012854 ssDNA binding site [nucleotide binding]; other site 290340012855 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290340012856 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290340012857 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290340012858 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340012859 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340012860 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340012861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340012862 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290340012863 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290340012864 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290340012865 active site 290340012866 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290340012867 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340012868 Amino acid permease; Region: AA_permease_2; pfam13520 290340012869 phenol 2-monooxygenase; Provisional; Region: PRK08294 290340012870 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 290340012871 dimer interface [polypeptide binding]; other site 290340012872 hypothetical protein; Provisional; Region: PRK12764 290340012873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290340012874 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290340012875 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340012876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340012877 DNA-binding site [nucleotide binding]; DNA binding site 290340012878 FCD domain; Region: FCD; pfam07729 290340012879 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 290340012880 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 290340012881 NAD binding site [chemical binding]; other site 290340012882 catalytic residues [active] 290340012883 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290340012884 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 290340012885 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012886 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290340012887 tetramerization interface [polypeptide binding]; other site 290340012888 NAD(P) binding site [chemical binding]; other site 290340012889 catalytic residues [active] 290340012890 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012891 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340012892 NAD(P) binding site [chemical binding]; other site 290340012893 catalytic residues [active] 290340012894 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340012895 classical (c) SDRs; Region: SDR_c; cd05233 290340012896 NAD(P) binding site [chemical binding]; other site 290340012897 active site 290340012898 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340012899 Phosphotransferase enzyme family; Region: APH; pfam01636 290340012900 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290340012901 active site 290340012902 ATP binding site [chemical binding]; other site 290340012903 substrate binding site [chemical binding]; other site 290340012904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340012905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340012906 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 290340012907 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340012908 inhibitor-cofactor binding pocket; inhibition site 290340012909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340012910 catalytic residue [active] 290340012911 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340012912 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290340012913 NAD(P) binding site [chemical binding]; other site 290340012914 catalytic residues [active] 290340012915 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290340012916 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 290340012917 EthD domain; Region: EthD; cl17553 290340012918 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340012919 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340012920 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290340012921 non-specific DNA interactions [nucleotide binding]; other site 290340012922 DNA binding site [nucleotide binding] 290340012923 sequence specific DNA binding site [nucleotide binding]; other site 290340012924 putative cAMP binding site [chemical binding]; other site 290340012925 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012926 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340012927 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340012928 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340012929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012930 putative substrate translocation pore; other site 290340012931 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290340012932 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 290340012933 ligand binding site [chemical binding]; other site 290340012934 NAD binding site [chemical binding]; other site 290340012935 dimerization interface [polypeptide binding]; other site 290340012936 catalytic site [active] 290340012937 hypothetical protein; Validated; Region: PRK06201 290340012938 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 290340012939 Isochorismatase family; Region: Isochorismatase; pfam00857 290340012940 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 290340012941 catalytic triad [active] 290340012942 conserved cis-peptide bond; other site 290340012943 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 290340012944 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290340012945 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 290340012946 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 290340012947 CGNR zinc finger; Region: zf-CGNR; pfam11706 290340012948 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290340012949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340012950 putative substrate translocation pore; other site 290340012951 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 290340012952 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340012953 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 290340012954 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290340012955 active site 290340012956 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290340012957 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 290340012958 substrate binding pocket [chemical binding]; other site 290340012959 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290340012960 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290340012961 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290340012962 tetramerization interface [polypeptide binding]; other site 290340012963 active site 290340012964 Right handed beta helix region; Region: Beta_helix; pfam13229 290340012965 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340012966 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290340012967 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012968 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340012969 Cupin domain; Region: Cupin_2; cl17218 290340012970 Methane oxygenase PmoA; Region: PmoA; pfam14100 290340012971 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290340012972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290340012973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290340012974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290340012975 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290340012976 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290340012977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340012978 dimer interface [polypeptide binding]; other site 290340012979 conserved gate region; other site 290340012980 putative PBP binding loops; other site 290340012981 ABC-ATPase subunit interface; other site 290340012982 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290340012983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290340012984 dimer interface [polypeptide binding]; other site 290340012985 conserved gate region; other site 290340012986 putative PBP binding loops; other site 290340012987 ABC-ATPase subunit interface; other site 290340012988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340012989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340012990 DNA binding site [nucleotide binding] 290340012991 domain linker motif; other site 290340012992 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340012993 ligand binding site [chemical binding]; other site 290340012994 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290340012995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290340012996 DNA binding site [nucleotide binding] 290340012997 domain linker motif; other site 290340012998 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290340012999 dimerization interface [polypeptide binding]; other site 290340013000 ligand binding site [chemical binding]; other site 290340013001 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 290340013002 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 290340013003 putative ligand binding site [chemical binding]; other site 290340013004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340013005 dimerization interface [polypeptide binding]; other site 290340013006 putative DNA binding site [nucleotide binding]; other site 290340013007 putative Zn2+ binding site [ion binding]; other site 290340013008 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 290340013009 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 290340013010 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 290340013011 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 290340013012 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 290340013013 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 290340013014 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290340013015 amidase; Provisional; Region: PRK07235 290340013016 adenylate kinase; Reviewed; Region: adk; PRK00279 290340013017 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290340013018 AMP-binding site [chemical binding]; other site 290340013019 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290340013020 citrate synthase; Provisional; Region: PRK14033 290340013021 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290340013022 oxalacetate binding site [chemical binding]; other site 290340013023 citrylCoA binding site [chemical binding]; other site 290340013024 coenzyme A binding site [chemical binding]; other site 290340013025 catalytic triad [active] 290340013026 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290340013027 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290340013028 tetramer interface [polypeptide binding]; other site 290340013029 active site 290340013030 Mg2+/Mn2+ binding site [ion binding]; other site 290340013031 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 290340013032 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340013033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340013034 DNA-binding site [nucleotide binding]; DNA binding site 290340013035 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290340013036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290340013037 acyl-activating enzyme (AAE) consensus motif; other site 290340013038 AMP binding site [chemical binding]; other site 290340013039 active site 290340013040 CoA binding site [chemical binding]; other site 290340013041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340013042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290340013043 putative substrate translocation pore; other site 290340013044 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290340013045 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290340013046 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290340013047 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290340013048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290340013049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290340013050 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290340013051 Domain of unknown function (DUF202); Region: DUF202; cl09954 290340013052 Domain of unknown function (DUF202); Region: DUF202; pfam02656 290340013053 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340013054 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 290340013055 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290340013056 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290340013057 metal-binding site [ion binding] 290340013058 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290340013059 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290340013060 transcriptional regulator NanR; Provisional; Region: PRK03837 290340013061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340013062 DNA-binding site [nucleotide binding]; DNA binding site 290340013063 FCD domain; Region: FCD; pfam07729 290340013064 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290340013065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290340013066 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290340013067 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290340013068 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290340013069 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290340013070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290340013071 DNA-binding site [nucleotide binding]; DNA binding site 290340013072 FCD domain; Region: FCD; pfam07729 290340013073 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290340013074 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290340013075 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290340013076 active site 290340013077 Creatinine amidohydrolase; Region: Creatininase; pfam02633 290340013078 metabolite-proton symporter; Region: 2A0106; TIGR00883 290340013079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290340013080 putative substrate translocation pore; other site 290340013081 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290340013082 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290340013083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290340013084 catalytic residue [active] 290340013085 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290340013086 homotrimer interaction site [polypeptide binding]; other site 290340013087 putative active site [active] 290340013088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290340013089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290340013090 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290340013091 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290340013092 active site residue [active] 290340013093 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290340013094 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290340013095 acetyl-CoA synthetase; Provisional; Region: PRK00174 290340013096 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290340013097 active site 290340013098 CoA binding site [chemical binding]; other site 290340013099 acyl-activating enzyme (AAE) consensus motif; other site 290340013100 AMP binding site [chemical binding]; other site 290340013101 acetate binding site [chemical binding]; other site 290340013102 ethanolamine permease; Region: 2A0305; TIGR00908 290340013103 tyramine oxidase; Provisional; Region: tynA; PRK11504 290340013104 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 290340013105 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290340013106 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290340013107 HTH-like domain; Region: HTH_21; pfam13276 290340013108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290340013109 Integrase core domain; Region: rve; pfam00665 290340013110 Integrase core domain; Region: rve_3; pfam13683 290340013111 Transposase; Region: HTH_Tnp_1; pfam01527 290340013112 Protein of unknown function (DUF779); Region: DUF779; pfam05610 290340013113 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290340013114 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340013115 NAD(P) binding site [chemical binding]; other site 290340013116 catalytic residues [active] 290340013117 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340013118 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290340013119 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 290340013120 Bacterial transcriptional regulator; Region: IclR; pfam01614 290340013121 Isochorismatase family; Region: Isochorismatase; pfam00857 290340013122 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 290340013123 catalytic triad [active] 290340013124 conserved cis-peptide bond; other site 290340013125 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 290340013126 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290340013127 conserved cys residue [active] 290340013128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340013129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290340013130 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290340013131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340013132 putative DNA binding site [nucleotide binding]; other site 290340013133 putative Zn2+ binding site [ion binding]; other site 290340013134 AsnC family; Region: AsnC_trans_reg; pfam01037 290340013135 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290340013136 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290340013137 hexamer interface [polypeptide binding]; other site 290340013138 ligand binding site [chemical binding]; other site 290340013139 putative active site [active] 290340013140 NAD(P) binding site [chemical binding]; other site 290340013141 Htaa; Region: HtaA; pfam04213 290340013142 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290340013143 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290340013144 catalytic triad [active] 290340013145 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290340013146 GAF domain; Region: GAF; pfam01590 290340013147 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290340013148 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290340013149 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290340013150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290340013151 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 290340013152 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 290340013153 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290340013154 Cytochrome P450; Region: p450; cl12078 290340013155 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290340013156 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290340013157 catalytic triad [active] 290340013158 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290340013159 classical (c) SDRs; Region: SDR_c; cd05233 290340013160 NAD(P) binding site [chemical binding]; other site 290340013161 active site 290340013162 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290340013163 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290340013164 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290340013165 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 290340013166 Flavodoxin; Region: Flavodoxin_1; pfam00258 290340013167 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 290340013168 FAD binding pocket [chemical binding]; other site 290340013169 FAD binding motif [chemical binding]; other site 290340013170 catalytic residues [active] 290340013171 NAD binding pocket [chemical binding]; other site 290340013172 phosphate binding motif [ion binding]; other site 290340013173 beta-alpha-beta structure motif; other site 290340013174 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290340013175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340013176 NAD(P) binding site [chemical binding]; other site 290340013177 catalytic residues [active] 290340013178 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290340013179 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290340013180 inhibitor-cofactor binding pocket; inhibition site 290340013181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290340013182 catalytic residue [active] 290340013183 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290340013184 NAD binding site [chemical binding]; other site 290340013185 catalytic Zn binding site [ion binding]; other site 290340013186 substrate binding site [chemical binding]; other site 290340013187 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 290340013188 structural Zn binding site [ion binding]; other site 290340013189 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290340013190 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 290340013191 NAD(P) binding site [chemical binding]; other site 290340013192 catalytic residues [active] 290340013193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290340013194 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290340013195 metal binding site [ion binding]; metal-binding site 290340013196 dimer interface [polypeptide binding]; other site 290340013197 Predicted transcriptional regulators [Transcription]; Region: COG1733 290340013198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290340013199 dimerization interface [polypeptide binding]; other site 290340013200 putative Zn2+ binding site [ion binding]; other site 290340013201 putative DNA binding site [nucleotide binding]; other site 290340013202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290340013203 NAD(P) binding site [chemical binding]; other site 290340013204 active site 290340013205 Sulfatase; Region: Sulfatase; cl17466 290340013206 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290340013207 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290340013208 catalytic residues [active] 290340013209 catalytic nucleophile [active] 290340013210 Presynaptic Site I dimer interface [polypeptide binding]; other site 290340013211 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290340013212 Synaptic Flat tetramer interface [polypeptide binding]; other site 290340013213 Synaptic Site I dimer interface [polypeptide binding]; other site 290340013214 DNA binding site [nucleotide binding] 290340013215 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290340013216 DNA-binding interface [nucleotide binding]; DNA binding site 290340013217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290340013218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290340013219 active site 290340013220 phosphorylation site [posttranslational modification] 290340013221 intermolecular recognition site; other site 290340013222 dimerization interface [polypeptide binding]; other site 290340013223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290340013224 DNA binding site [nucleotide binding] 290340013225 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290340013226 tetramer interface; other site 290340013227 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290340013228 active site 290340013229 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 290340013230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290340013231 TM1410 hypothetical-related protein; Region: DUF297; cl00997 290340013232 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290340013233 UDP-glucose 4-epimerase; Region: PLN02240 290340013234 NAD binding site [chemical binding]; other site 290340013235 homodimer interface [polypeptide binding]; other site 290340013236 active site 290340013237 substrate binding site [chemical binding]; other site 290340013238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290340013239 PAS domain; Region: PAS_9; pfam13426 290340013240 putative active site [active] 290340013241 heme pocket [chemical binding]; other site 290340013242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290340013243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290340013244 metal binding site [ion binding]; metal-binding site 290340013245 active site 290340013246 I-site; other site 290340013247 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290340013248 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 290340013249 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290340013250 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290340013251 GAF domain; Region: GAF_2; pfam13185 290340013252 ANTAR domain; Region: ANTAR; pfam03861 290340013253 MarR family; Region: MarR; pfam01047 290340013254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290340013255 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290340013256 substrate binding site [chemical binding]; other site 290340013257 ATP binding site [chemical binding]; other site 290340013258 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 290340013259 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290340013260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290340013261 active site 290340013262 DNA binding site [nucleotide binding] 290340013263 Int/Topo IB signature motif; other site 290340013264 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290340013265 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340013266 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 290340013267 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290340013268 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290340013269 active site 290340013270 catalytic residues [active] 290340013271 DNA binding site [nucleotide binding] 290340013272 Int/Topo IB signature motif; other site 290340013273 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340013274 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290340013275 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290340013276 active site 290340013277 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 290340013278 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290340013279 AAA-like domain; Region: AAA_10; pfam12846 290340013280 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290340013281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290340013282 CHAP domain; Region: CHAP; cl17642 290340013283 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525 290340013284 nucleotide binding site [chemical binding]; other site