-- dump date   	20140618_205313
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
452863000001	thymidylate synthase; Reviewed; Region: thyA; PRK01827
452863000002	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
452863000003	dimerization interface [polypeptide binding]; other site
452863000004	active site
452863000005	Yqey-like protein; Region: YqeY; cl17540
452863000006	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
452863000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863000008	Walker A motif; other site
452863000009	ATP binding site [chemical binding]; other site
452863000010	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
452863000011	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
452863000012	folate binding site [chemical binding]; other site
452863000013	NADP+ binding site [chemical binding]; other site
452863000014	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
452863000015	active site
452863000016	putative substrate binding region [chemical binding]; other site
452863000017	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
452863000018	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
452863000019	SecY translocase; Region: SecY; pfam00344
452863000020	RNA polymerase II transcription elongation factor; Region: EAF; pfam09816
452863000021	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
452863000022	active site
452863000023	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
452863000024	ADP-ribose binding site [chemical binding]; other site
452863000025	dimer interface [polypeptide binding]; other site
452863000026	active site
452863000027	nudix motif; other site
452863000028	metal binding site [ion binding]; metal-binding site
452863000029	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
452863000030	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
452863000031	dimer interface [polypeptide binding]; other site
452863000032	active site
452863000033	ADP-ribose binding site [chemical binding]; other site
452863000034	nudix motif; other site
452863000035	metal binding site [ion binding]; metal-binding site
452863000036	Fic family protein [Function unknown]; Region: COG3177
452863000037	Fic/DOC family; Region: Fic; pfam02661
452863000038	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
452863000039	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
452863000040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863000041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863000042	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
452863000043	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863000044	active site
452863000045	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
452863000046	classical (c) SDRs; Region: SDR_c; cd05233
452863000047	NAD(P) binding site [chemical binding]; other site
452863000048	active site
452863000049	non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276
452863000050	RNA/DNA hybrid binding site [nucleotide binding]; other site
452863000051	active site
452863000052	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
452863000053	Lsr2; Region: Lsr2; pfam11774
452863000054	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
452863000055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863000056	Walker A/P-loop; other site
452863000057	ATP binding site [chemical binding]; other site
452863000058	Q-loop/lid; other site
452863000059	ABC transporter signature motif; other site
452863000060	Walker B; other site
452863000061	D-loop; other site
452863000062	H-loop/switch region; other site
452863000063	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
452863000064	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
452863000065	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
452863000066	Bax inhibitor 1 like; Region: BaxI_1; cl17691
452863000067	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
452863000068	trimer interface [polypeptide binding]; other site
452863000069	active site
452863000070	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
452863000071	active site
452863000072	NTP binding site [chemical binding]; other site
452863000073	metal binding triad [ion binding]; metal-binding site
452863000074	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
452863000075	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
452863000076	Zn2+ binding site [ion binding]; other site
452863000077	Mg2+ binding site [ion binding]; other site
452863000078	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863000079	DNA-binding site [nucleotide binding]; DNA binding site
452863000080	RNA-binding motif; other site
452863000081	copper exporting ATPase; Provisional; Region: copA; PRK10671
452863000082	hypothetical protein; Validated; Region: PRK00068
452863000083	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
452863000084	Thg1 C terminal domain; Region: Thg1C; pfam14413
452863000085	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863000086	Catalytic site [active]
452863000087	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863000088	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
452863000089	Walker A/P-loop; other site
452863000090	ATP binding site [chemical binding]; other site
452863000091	Q-loop/lid; other site
452863000092	ABC transporter signature motif; other site
452863000093	Walker B; other site
452863000094	D-loop; other site
452863000095	H-loop/switch region; other site
452863000096	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
452863000097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
452863000098	LGFP repeat; Region: LGFP; pfam08310
452863000099	LGFP repeat; Region: LGFP; pfam08310
452863000100	LGFP repeat; Region: LGFP; pfam08310
452863000101	LGFP repeat; Region: LGFP; pfam08310
452863000102	LGFP repeat; Region: LGFP; pfam08310
452863000103	LGFP repeat; Region: LGFP; pfam08310
452863000104	LGFP repeat; Region: LGFP; pfam08310
452863000105	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
452863000106	DNA methylase; Region: N6_N4_Mtase; pfam01555
452863000107	DNA methylase; Region: N6_N4_Mtase; cl17433
452863000108	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
452863000109	Restriction endonuclease [Defense mechanisms]; Region: COG3587
452863000110	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863000111	Coenzyme A binding pocket [chemical binding]; other site
452863000112	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863000113	putative active site [active]
452863000114	Helicase associated domain; Region: HA; pfam03457
452863000115	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
452863000116	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
452863000117	RNase_H superfamily; Region: RNase_H_2; pfam13482
452863000118	Fic/DOC family; Region: Fic; cl00960
452863000119	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
452863000120	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863000121	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863000122	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863000123	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
452863000124	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
452863000125	N-acetyl-D-glucosamine binding site [chemical binding]; other site
452863000126	catalytic residue [active]
452863000127	TM2 domain; Region: TM2; pfam05154
452863000128	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
452863000129	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
452863000130	putative catalytic site [active]
452863000131	putative metal binding site [ion binding]; other site
452863000132	putative phosphate binding site [ion binding]; other site
452863000133	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
452863000134	active site
452863000135	catalytic site [active]
452863000136	substrate binding site [chemical binding]; other site
452863000137	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
452863000138	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
452863000139	active site
452863000140	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
452863000141	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
452863000142	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
452863000143	Protein of unknown function (DUF544); Region: DUF544; pfam04424
452863000144	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863000145	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863000146	DNA binding residues [nucleotide binding]
452863000147	dimerization interface [polypeptide binding]; other site
452863000148	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
452863000149	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863000150	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
452863000151	Protein of unknown function (DUF805); Region: DUF805; pfam05656
452863000152	AAA domain; Region: AAA_22; pfam13401
452863000153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863000154	ATP binding site [chemical binding]; other site
452863000155	putative Mg++ binding site [ion binding]; other site
452863000156	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
452863000157	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
452863000158	metal ion-dependent adhesion site (MIDAS); other site
452863000159	non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276
452863000160	RNA/DNA hybrid binding site [nucleotide binding]; other site
452863000161	active site
452863000162	multiple promoter invertase; Provisional; Region: mpi; PRK13413
452863000163	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863000164	catalytic residues [active]
452863000165	catalytic nucleophile [active]
452863000166	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863000167	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863000168	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863000169	Synaptic Site I dimer interface [polypeptide binding]; other site
452863000170	DNA binding site [nucleotide binding]
452863000171	Nuclease-related domain; Region: NERD; pfam08378
452863000172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863000173	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
452863000174	Walker A motif; other site
452863000175	ATP binding site [chemical binding]; other site
452863000176	Walker B motif; other site
452863000177	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
452863000178	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
452863000179	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
452863000180	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863000181	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
452863000182	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
452863000183	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863000184	HNH endonuclease; Region: HNH_2; pfam13391
452863000185	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
452863000186	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863000187	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
452863000188	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863000189	Walker A motif; other site
452863000190	ATP binding site [chemical binding]; other site
452863000191	Walker B motif; other site
452863000192	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
452863000193	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863000194	Walker A motif; other site
452863000195	ATP binding site [chemical binding]; other site
452863000196	Walker B motif; other site
452863000197	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
452863000198	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
452863000199	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863000200	Walker A motif; other site
452863000201	ATP binding site [chemical binding]; other site
452863000202	Walker B motif; other site
452863000203	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
452863000204	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
452863000205	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863000206	Walker A motif; other site
452863000207	ATP binding site [chemical binding]; other site
452863000208	Walker B motif; other site
452863000209	Competence protein A; Region: Competence_A; pfam11104
452863000210	Pilus assembly protein, PilO; Region: PilO; cl01234
452863000211	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
452863000212	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863000213	AbgT putative transporter family; Region: ABG_transport; cl17431
452863000214	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863000215	S-layer homology domain; Region: SLH; pfam00395
452863000216	S-layer homology domain; Region: SLH; pfam00395
452863000217	LGFP repeat; Region: LGFP; pfam08310
452863000218	LGFP repeat; Region: LGFP; pfam08310
452863000219	LGFP repeat; Region: LGFP; pfam08310
452863000220	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863000221	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863000222	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
452863000223	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
452863000224	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
452863000225	cofactor binding site; other site
452863000226	DNA binding site [nucleotide binding]
452863000227	substrate interaction site [chemical binding]; other site
452863000228	MarR family; Region: MarR_2; pfam12802
452863000229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863000230	non-specific DNA binding site [nucleotide binding]; other site
452863000231	salt bridge; other site
452863000232	sequence-specific DNA binding site [nucleotide binding]; other site
452863000233	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863000234	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863000235	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863000236	Magnesium ion binding site [ion binding]; other site
452863000237	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
452863000238	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
452863000239	active site
452863000240	metal binding site [ion binding]; metal-binding site
452863000241	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
452863000242	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
452863000243	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
452863000244	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
452863000245	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
452863000246	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
452863000247	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
452863000248	Helix-turn-helix domain; Region: HTH_17; pfam12728
452863000249	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863000250	Nuclease-related domain; Region: NERD; pfam08378
452863000251	AAA-like domain; Region: AAA_10; pfam12846
452863000252	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
452863000253	Clp amino terminal domain; Region: Clp_N; pfam02861
452863000254	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
452863000255	Clp amino terminal domain; Region: Clp_N; pfam02861
452863000256	Clp amino terminal domain; Region: Clp_N; pfam02861
452863000257	Clp amino terminal domain; Region: Clp_N; pfam02861
452863000258	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
452863000259	active site
452863000260	Zn binding site [ion binding]; other site
452863000261	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
452863000262	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
452863000263	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
452863000264	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
452863000265	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
452863000266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863000267	motif II; other site
452863000268	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
452863000269	Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485
452863000270	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
452863000271	active site
452863000272	DNA binding site [nucleotide binding]
452863000273	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
452863000274	DNA binding site [nucleotide binding]
452863000275	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
452863000276	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
452863000277	Helicase associated domain; Region: HA; pfam03457
452863000278	Helicase associated domain; Region: HA; pfam03457
452863000279	Helicase associated domain; Region: HA; pfam03457
452863000280	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
452863000281	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863000282	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
452863000283	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
452863000284	Catalytic site [active]
452863000285	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
452863000286	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
452863000287	active site
452863000288	DNA binding site [nucleotide binding]
452863000289	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
452863000290	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
452863000291	Phage maturation protein; Region: Phage_mat-A; cl17797
452863000292	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
452863000293	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
452863000294	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
452863000295	catalytic site [active]
452863000296	putative active site [active]
452863000297	putative substrate binding site [chemical binding]; other site
452863000298	dimer interface [polypeptide binding]; other site
452863000299	Short C-terminal domain; Region: SHOCT; pfam09851
452863000300	RNA ligase; Region: RNA_ligase; pfam09414
452863000301	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
452863000302	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
452863000303	YcfA-like protein; Region: YcfA; cl00752
452863000304	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
452863000305	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
452863000306	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863000307	active site
452863000308	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
452863000309	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
452863000310	nucleotide binding pocket [chemical binding]; other site
452863000311	K-X-D-G motif; other site
452863000312	catalytic site [active]
452863000313	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
452863000314	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
452863000315	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
452863000316	Dimer interface [polypeptide binding]; other site
452863000317	Cation efflux family; Region: Cation_efflux; pfam01545
452863000318	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
452863000319	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
452863000320	active site
452863000321	metal binding site [ion binding]; metal-binding site
452863000322	Transglycosylase; Region: Transgly; pfam00912
452863000323	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
452863000324	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
452863000325	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863000326	putative diguanylate cyclase; Provisional; Region: PRK09776
452863000327	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863000328	HD domain; Region: HD_4; pfam13328
452863000329	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
452863000330	dimer interface [polypeptide binding]; other site
452863000331	putative active site [active]
452863000332	polynucleotide kinase; Provisional; Region: pseT; PHA02530
452863000333	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
452863000334	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
452863000335	HTH domain; Region: HTH_11; cl17392
452863000336	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
452863000337	AAA-like domain; Region: AAA_10; pfam12846
452863000338	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
452863000339	activation loop (A-loop); other site
452863000340	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
452863000341	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863000342	catalytic residues [active]
452863000343	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
452863000344	DNA methylase; Region: N6_N4_Mtase; pfam01555
452863000345	DNA methylase; Region: N6_N4_Mtase; pfam01555
452863000346	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
452863000347	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
452863000348	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
452863000349	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
452863000350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863000351	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
452863000352	NAD(P) binding site [chemical binding]; other site
452863000353	active site
452863000354	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
452863000355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
452863000356	ATP binding site [chemical binding]; other site
452863000357	helicase superfamily c-terminal domain; Region: HELICc; smart00490
452863000358	ATP-binding site [chemical binding]; other site
452863000359	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
452863000360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863000361	Trp repressor protein; Region: Trp_repressor; cl17266
452863000362	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
452863000363	Surface antigen [General function prediction only]; Region: COG3942
452863000364	CHAP domain; Region: CHAP; pfam05257
452863000365	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863000366	active site
452863000367	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
452863000368	dimer interface [polypeptide binding]; other site
452863000369	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
452863000370	ssDNA binding site [nucleotide binding]; other site
452863000371	tetramer (dimer of dimers) interface [polypeptide binding]; other site
452863000372	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
452863000373	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
452863000374	active site
452863000375	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571
452863000376	OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336
452863000377	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
452863000378	PHP domain; Region: PHP; pfam02811
452863000379	active site
452863000380	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
452863000381	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
452863000382	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
452863000383	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863000384	ATP binding site [chemical binding]; other site
452863000385	putative Mg++ binding site [ion binding]; other site
452863000386	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863000387	nucleotide binding region [chemical binding]; other site
452863000388	ATP-binding site [chemical binding]; other site
452863000389	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
452863000390	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863000391	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
452863000392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863000393	DNA binding residues [nucleotide binding]
452863000394	Helicase associated domain; Region: HA; pfam03457
452863000395	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
452863000396	TadE-like protein; Region: TadE; pfam07811
452863000397	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
452863000398	septum site-determining protein MinD; Region: minD_bact; TIGR01968
452863000399	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863000400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863000401	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
452863000402	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
452863000403	ATP binding site [chemical binding]; other site
452863000404	Walker A motif; other site
452863000405	hexamer interface [polypeptide binding]; other site
452863000406	Walker B motif; other site
452863000407	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863000408	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863000409	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
452863000410	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863000411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
452863000412	LGFP repeat; Region: LGFP; pfam08310
452863000413	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
452863000414	LGFP repeat; Region: LGFP; pfam08310
452863000415	LGFP repeat; Region: LGFP; pfam08310
452863000416	LGFP repeat; Region: LGFP; pfam08310
452863000417	LGFP repeat; Region: LGFP; pfam08310
452863000418	LGFP repeat; Region: LGFP; pfam08310
452863000419	LGFP repeat; Region: LGFP; pfam08310
452863000420	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
452863000421	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
452863000422	active site
452863000423	catalytic site [active]
452863000424	substrate binding site [chemical binding]; other site
452863000425	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
452863000426	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
452863000427	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
452863000428	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
452863000429	Class I ribonucleotide reductase; Region: RNR_I; cd01679
452863000430	active site
452863000431	dimer interface [polypeptide binding]; other site
452863000432	catalytic residues [active]
452863000433	effector binding site; other site
452863000434	R2 peptide binding site; other site
452863000435	Lsr2; Region: Lsr2; pfam11774
452863000436	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
452863000437	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
452863000438	dimer interface [polypeptide binding]; other site
452863000439	putative radical transfer pathway; other site
452863000440	diiron center [ion binding]; other site
452863000441	tyrosyl radical; other site
452863000442	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
452863000443	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
452863000444	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
452863000445	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
452863000446	IHF dimer interface [polypeptide binding]; other site
452863000447	IHF - DNA interface [nucleotide binding]; other site
452863000448	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
452863000449	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
452863000450	HSP70 interaction site [polypeptide binding]; other site
452863000451	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
452863000452	hypothetical protein; Reviewed; Region: PRK09588
452863000453	Plant protein of unknown function (DUF946); Region: DUF946; pfam06101
452863000454	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
452863000455	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
452863000456	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
452863000457	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
452863000458	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
452863000459	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
452863000460	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
452863000461	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
452863000462	Catalytic site [active]
452863000463	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
452863000464	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
452863000465	active site
452863000466	DNA binding site [nucleotide binding]
452863000467	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
452863000468	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
452863000469	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
452863000470	active site
452863000471	DNA binding site [nucleotide binding]
452863000472	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
452863000473	DNA binding site [nucleotide binding]
452863000474	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
452863000475	PLD-like domain; Region: PLDc_2; pfam13091
452863000476	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
452863000477	putative homodimer interface [polypeptide binding]; other site
452863000478	putative active site [active]
452863000479	catalytic site [active]
452863000480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863000481	ATP binding site [chemical binding]; other site
452863000482	putative Mg++ binding site [ion binding]; other site
452863000483	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
452863000484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863000485	nucleotide binding region [chemical binding]; other site
452863000486	ATP-binding site [chemical binding]; other site
452863000487	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
452863000488	cobyric acid synthase; Provisional; Region: PRK00784
452863000489	TIR domain; Region: TIR_2; pfam13676
452863000490	putative transposase OrfB; Reviewed; Region: PHA02517
452863000491	HTH-like domain; Region: HTH_21; pfam13276
452863000492	Integrase core domain; Region: rve; pfam00665
452863000493	Integrase core domain; Region: rve_3; cl15866
452863000494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
452863000495	Transposase; Region: HTH_Tnp_1; cl17663
452863000496	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
452863000497	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863000498	DNA binding residues [nucleotide binding]
452863000499	dimer interface [polypeptide binding]; other site
452863000500	metal binding site [ion binding]; metal-binding site
452863000501	mercuric reductase; Region: MerA; TIGR02053
452863000502	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863000503	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863000504	alkylmercury lyase; Provisional; Region: PRK13239
452863000505	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
452863000506	Alkylmercury lyase; Region: MerB; pfam03243
452863000507	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
452863000508	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863000509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863000510	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863000511	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
452863000512	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
452863000513	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
452863000514	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
452863000515	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
452863000516	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
452863000517	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
452863000518	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
452863000519	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
452863000520	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
452863000521	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
452863000522	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
452863000523	catalytic residues [active]
452863000524	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
452863000525	Domain of unknown function (DUF305); Region: DUF305; pfam03713
452863000526	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
452863000527	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
452863000528	catalytic residues [active]
452863000529	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
452863000530	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
452863000531	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863000532	DNA binding residues [nucleotide binding]
452863000533	dimer interface [polypeptide binding]; other site
452863000534	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863000535	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
452863000536	catalytic residues [active]
452863000537	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863000538	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863000539	Copper resistance protein D; Region: CopD; cl00563
452863000540	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
452863000541	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
452863000542	CopC domain; Region: CopC; pfam04234
452863000543	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
452863000544	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863000545	catalytic residues [active]
452863000546	catalytic nucleophile [active]
452863000547	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863000548	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863000549	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863000550	Synaptic Site I dimer interface [polypeptide binding]; other site
452863000551	DNA binding site [nucleotide binding]
452863000552	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
452863000553	DNA-binding interface [nucleotide binding]; DNA binding site
452863000554	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
452863000555	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863000556	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863000557	catalytic residues [active]
452863000558	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863000559	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863000560	Synaptic Site I dimer interface [polypeptide binding]; other site
452863000561	DNA binding site [nucleotide binding]
452863000562	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
452863000563	DNA-binding interface [nucleotide binding]; DNA binding site
452863000564	Methyltransferase domain; Region: Methyltransf_26; pfam13659
452863000565	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
452863000566	DEAD-like helicases superfamily; Region: DEXDc; smart00487
452863000567	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
452863000568	helicase superfamily c-terminal domain; Region: HELICc; smart00490
452863000569	nucleotide binding region [chemical binding]; other site
452863000570	ATP-binding site [chemical binding]; other site
452863000571	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
452863000572	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863000573	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863000574	Magnesium ion binding site [ion binding]; other site
452863000575	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
452863000576	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
452863000577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863000578	NAD(P) binding site [chemical binding]; other site
452863000579	active site
452863000580	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863000581	putative DNA binding site [nucleotide binding]; other site
452863000582	putative Zn2+ binding site [ion binding]; other site
452863000583	Helix-turn-helix domain; Region: HTH_20; pfam12840
452863000584	CHAP domain; Region: CHAP; cl17642
452863000585	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
452863000586	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863000587	AAA-like domain; Region: AAA_10; pfam12846
452863000588	Domain of unknown function DUF87; Region: DUF87; pfam01935
452863000589	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863000590	ATP binding site [chemical binding]; other site
452863000591	Walker A motif; other site
452863000592	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
452863000593	Walker B motif; other site
452863000594	Lsr2; Region: Lsr2; pfam11774
452863000595	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
452863000596	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863000597	FAD binding domain; Region: FAD_binding_3; pfam01494
452863000598	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863000599	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
452863000600	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
452863000601	active site
452863000602	dimer interface [polypeptide binding]; other site
452863000603	metal binding site [ion binding]; metal-binding site
452863000604	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
452863000605	dimer interface [polypeptide binding]; other site
452863000606	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
452863000607	active site
452863000608	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
452863000609	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
452863000610	dimer interface [polypeptide binding]; other site
452863000611	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
452863000612	active site
452863000613	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
452863000614	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
452863000615	putative Zn2+ binding site [ion binding]; other site
452863000616	putative DNA binding site [nucleotide binding]; other site
452863000617	Bacterial transcriptional activator domain; Region: BTAD; smart01043
452863000618	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
452863000619	4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794
452863000620	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
452863000621	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
452863000622	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
452863000623	active site
452863000624	dimer interface [polypeptide binding]; other site
452863000625	metal binding site [ion binding]; metal-binding site
452863000626	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863000627	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863000628	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
452863000629	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
452863000630	dimer interface [polypeptide binding]; other site
452863000631	active site
452863000632	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863000633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863000634	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
452863000635	L-aspartate oxidase; Provisional; Region: PRK06175
452863000636	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
452863000637	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863000638	NADH(P)-binding; Region: NAD_binding_10; pfam13460
452863000639	NAD(P) binding site [chemical binding]; other site
452863000640	active site
452863000641	Predicted transcriptional regulator [Transcription]; Region: COG1959
452863000642	Transcriptional regulator; Region: Rrf2; pfam02082
452863000643	Predicted transcriptional regulator [Transcription]; Region: COG1959
452863000644	Transcriptional regulator; Region: Rrf2; pfam02082
452863000645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863000646	NADH(P)-binding; Region: NAD_binding_10; pfam13460
452863000647	NAD(P) binding site [chemical binding]; other site
452863000648	active site
452863000649	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
452863000650	active site
452863000651	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
452863000652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863000653	hypothetical protein; Provisional; Region: PRK07236
452863000654	FAD binding domain; Region: FAD_binding_3; pfam01494
452863000655	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863000656	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
452863000657	Zn binding site [ion binding]; other site
452863000658	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
452863000659	Zn binding site [ion binding]; other site
452863000660	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
452863000661	putative hydrolase; Provisional; Region: PRK11460
452863000662	Uncharacterized conserved protein [Function unknown]; Region: COG2353
452863000663	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
452863000664	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
452863000665	active site
452863000666	dimer interface [polypeptide binding]; other site
452863000667	metal binding site [ion binding]; metal-binding site
452863000668	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
452863000669	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863000670	dimer interface [polypeptide binding]; other site
452863000671	active site
452863000672	Coenzyme A transferase; Region: CoA_trans; cl17247
452863000673	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
452863000674	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863000675	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863000676	multiple promoter invertase; Provisional; Region: mpi; PRK13413
452863000677	catalytic residues [active]
452863000678	catalytic nucleophile [active]
452863000679	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863000680	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863000681	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863000682	Synaptic Site I dimer interface [polypeptide binding]; other site
452863000683	DNA binding site [nucleotide binding]
452863000684	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
452863000685	DNA-binding interface [nucleotide binding]; DNA binding site
452863000686	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863000687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863000688	sequence-specific DNA binding site [nucleotide binding]; other site
452863000689	salt bridge; other site
452863000690	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
452863000691	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863000692	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
452863000693	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863000694	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
452863000695	putative substrate binding site [chemical binding]; other site
452863000696	putative ATP binding site [chemical binding]; other site
452863000697	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863000698	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
452863000699	TM-ABC transporter signature motif; other site
452863000700	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
452863000701	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
452863000702	Walker A/P-loop; other site
452863000703	ATP binding site [chemical binding]; other site
452863000704	Q-loop/lid; other site
452863000705	ABC transporter signature motif; other site
452863000706	Walker B; other site
452863000707	D-loop; other site
452863000708	H-loop/switch region; other site
452863000709	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
452863000710	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
452863000711	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
452863000712	putative ligand binding site [chemical binding]; other site
452863000713	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863000714	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863000715	DNA binding site [nucleotide binding]
452863000716	domain linker motif; other site
452863000717	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863000718	ligand binding site [chemical binding]; other site
452863000719	dimerization interface [polypeptide binding]; other site
452863000720	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863000721	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863000722	DNA binding site [nucleotide binding]
452863000723	domain linker motif; other site
452863000724	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863000725	putative dimerization interface [polypeptide binding]; other site
452863000726	putative ligand binding site [chemical binding]; other site
452863000727	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863000728	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863000729	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
452863000730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000731	dimer interface [polypeptide binding]; other site
452863000732	conserved gate region; other site
452863000733	putative PBP binding loops; other site
452863000734	ABC-ATPase subunit interface; other site
452863000735	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863000736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000737	dimer interface [polypeptide binding]; other site
452863000738	conserved gate region; other site
452863000739	putative PBP binding loops; other site
452863000740	ABC-ATPase subunit interface; other site
452863000741	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
452863000742	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863000743	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
452863000744	putative substrate binding site [chemical binding]; other site
452863000745	putative ATP binding site [chemical binding]; other site
452863000746	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
452863000747	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
452863000748	fructose-1,6-bisphosphate binding site; other site
452863000749	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863000750	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863000751	DNA binding site [nucleotide binding]
452863000752	domain linker motif; other site
452863000753	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863000754	dimerization interface [polypeptide binding]; other site
452863000755	ligand binding site [chemical binding]; other site
452863000756	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863000757	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863000758	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863000759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000760	putative PBP binding loops; other site
452863000761	dimer interface [polypeptide binding]; other site
452863000762	ABC-ATPase subunit interface; other site
452863000763	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863000764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000765	dimer interface [polypeptide binding]; other site
452863000766	conserved gate region; other site
452863000767	putative PBP binding loops; other site
452863000768	ABC-ATPase subunit interface; other site
452863000769	Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995
452863000770	active site
452863000771	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
452863000772	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
452863000773	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
452863000774	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
452863000775	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
452863000776	Helicase associated domain; Region: HA; pfam03457
452863000777	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
452863000778	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
452863000779	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
452863000780	Helix-turn-helix domain; Region: HTH_17; pfam12728
452863000781	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
452863000782	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
452863000783	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
452863000784	dimer interface [polypeptide binding]; other site
452863000785	ssDNA binding site [nucleotide binding]; other site
452863000786	tetramer (dimer of dimers) interface [polypeptide binding]; other site
452863000787	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
452863000788	catalytic residues [active]
452863000789	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
452863000790	ParB-like nuclease domain; Region: ParB; smart00470
452863000791	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
452863000792	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
452863000793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863000794	Walker A motif; other site
452863000795	ATP binding site [chemical binding]; other site
452863000796	Walker B motif; other site
452863000797	arginine finger; other site
452863000798	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
452863000799	DnaA box-binding interface [nucleotide binding]; other site
452863000800	DNA polymerase III subunit beta; Validated; Region: PRK07761
452863000801	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
452863000802	putative DNA binding surface [nucleotide binding]; other site
452863000803	dimer interface [polypeptide binding]; other site
452863000804	beta-clamp/clamp loader binding surface; other site
452863000805	beta-clamp/translesion DNA polymerase binding surface; other site
452863000806	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863000807	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
452863000808	recombination protein F; Reviewed; Region: recF; PRK00064
452863000809	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
452863000810	Walker A/P-loop; other site
452863000811	ATP binding site [chemical binding]; other site
452863000812	Q-loop/lid; other site
452863000813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863000814	ABC transporter signature motif; other site
452863000815	Walker B; other site
452863000816	D-loop; other site
452863000817	H-loop/switch region; other site
452863000818	Protein of unknown function (DUF721); Region: DUF721; cl02324
452863000819	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
452863000820	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
452863000821	anchoring element; other site
452863000822	dimer interface [polypeptide binding]; other site
452863000823	ATP binding site [chemical binding]; other site
452863000824	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
452863000825	active site
452863000826	putative metal-binding site [ion binding]; other site
452863000827	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
452863000828	DNA gyrase subunit A; Validated; Region: PRK05560
452863000829	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
452863000830	CAP-like domain; other site
452863000831	active site
452863000832	primary dimer interface [polypeptide binding]; other site
452863000833	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000834	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000835	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000836	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000837	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000838	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863000839	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
452863000840	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
452863000841	EamA-like transporter family; Region: EamA; cl17759
452863000842	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863000843	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
452863000844	active site
452863000845	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863000846	PRTRC system protein E; Region: PRTRC_E; TIGR03741
452863000847	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
452863000848	active site
452863000849	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
452863000850	Zn2+ binding site [ion binding]; other site
452863000851	Rhomboid family; Region: Rhomboid; pfam01694
452863000852	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
452863000853	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
452863000854	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
452863000855	active site
452863000856	catalytic site [active]
452863000857	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
452863000858	Glutamine amidotransferase class-I; Region: GATase; pfam00117
452863000859	glutamine binding [chemical binding]; other site
452863000860	catalytic triad [active]
452863000861	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
452863000862	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863000863	active site
452863000864	ATP binding site [chemical binding]; other site
452863000865	substrate binding site [chemical binding]; other site
452863000866	activation loop (A-loop); other site
452863000867	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863000868	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863000869	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863000870	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863000871	Catalytic domain of Protein Kinases; Region: PKc; cd00180
452863000872	active site
452863000873	ATP binding site [chemical binding]; other site
452863000874	substrate binding site [chemical binding]; other site
452863000875	activation loop (A-loop); other site
452863000876	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863000877	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
452863000878	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
452863000879	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
452863000880	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
452863000881	active site
452863000882	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
452863000883	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
452863000884	phosphopeptide binding site; other site
452863000885	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
452863000886	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
452863000887	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
452863000888	phosphopeptide binding site; other site
452863000889	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
452863000890	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
452863000891	putative ligand binding site [chemical binding]; other site
452863000892	NAD binding site [chemical binding]; other site
452863000893	catalytic site [active]
452863000894	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863000895	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
452863000896	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863000897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000898	dimer interface [polypeptide binding]; other site
452863000899	conserved gate region; other site
452863000900	putative PBP binding loops; other site
452863000901	ABC-ATPase subunit interface; other site
452863000902	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863000903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863000904	dimer interface [polypeptide binding]; other site
452863000905	conserved gate region; other site
452863000906	putative PBP binding loops; other site
452863000907	ABC-ATPase subunit interface; other site
452863000908	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
452863000909	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863000910	Walker A/P-loop; other site
452863000911	ATP binding site [chemical binding]; other site
452863000912	Q-loop/lid; other site
452863000913	ABC transporter signature motif; other site
452863000914	Walker B; other site
452863000915	D-loop; other site
452863000916	H-loop/switch region; other site
452863000917	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863000918	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
452863000919	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863000920	Walker A/P-loop; other site
452863000921	ATP binding site [chemical binding]; other site
452863000922	Q-loop/lid; other site
452863000923	ABC transporter signature motif; other site
452863000924	Walker B; other site
452863000925	D-loop; other site
452863000926	H-loop/switch region; other site
452863000927	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863000928	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
452863000929	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
452863000930	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
452863000931	putative ligand binding site [chemical binding]; other site
452863000932	NAD binding site [chemical binding]; other site
452863000933	dimer interface [polypeptide binding]; other site
452863000934	putative catalytic site [active]
452863000935	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
452863000936	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
452863000937	active site
452863000938	tetramer interface [polypeptide binding]; other site
452863000939	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
452863000940	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863000941	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
452863000942	putative dimerization interface [polypeptide binding]; other site
452863000943	putative substrate binding pocket [chemical binding]; other site
452863000944	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863000945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863000946	DNA-binding site [nucleotide binding]; DNA binding site
452863000947	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
452863000948	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
452863000949	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
452863000950	active site pocket [active]
452863000951	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863000952	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863000953	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
452863000954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863000955	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
452863000956	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
452863000957	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
452863000958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
452863000959	SnoaL-like domain; Region: SnoaL_2; pfam12680
452863000960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863000961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863000962	methylenetetrahydrofolate reductase; Region: PLN02540
452863000963	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863000964	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
452863000965	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
452863000966	dimerization interface [polypeptide binding]; other site
452863000967	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
452863000968	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
452863000969	MarR family; Region: MarR; pfam01047
452863000970	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
452863000971	FAD binding domain; Region: FAD_binding_4; pfam01565
452863000972	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
452863000973	alpha-galactosidase; Region: PLN02808; cl17638
452863000974	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
452863000975	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
452863000976	amidase; Validated; Region: PRK06565
452863000977	Amidase; Region: Amidase; cl11426
452863000978	Amidase; Region: Amidase; cl11426
452863000979	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
452863000980	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
452863000981	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863000982	ribosome small subunit-dependent GTPase A; Region: TIGR00157
452863000983	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
452863000984	GTPase/Zn-binding domain interface [polypeptide binding]; other site
452863000985	GTP/Mg2+ binding site [chemical binding]; other site
452863000986	G4 box; other site
452863000987	G5 box; other site
452863000988	G1 box; other site
452863000989	Switch I region; other site
452863000990	G2 box; other site
452863000991	G3 box; other site
452863000992	Switch II region; other site
452863000993	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
452863000994	Domain of unknown function DUF21; Region: DUF21; pfam01595
452863000995	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
452863000996	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
452863000997	Domain of unknown function DUF21; Region: DUF21; pfam01595
452863000998	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
452863000999	Transporter associated domain; Region: CorC_HlyC; smart01091
452863001000	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
452863001001	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
452863001002	metal binding site [ion binding]; metal-binding site
452863001003	active site
452863001004	I-site; other site
452863001005	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001006	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001007	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001008	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
452863001009	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001010	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001011	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001012	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001013	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001014	DNA binding site [nucleotide binding]
452863001015	domain linker motif; other site
452863001016	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863001017	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
452863001018	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
452863001019	Sulfate transporter family; Region: Sulfate_transp; pfam00916
452863001020	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
452863001021	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
452863001022	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863001023	DNA binding residues [nucleotide binding]
452863001024	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
452863001025	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
452863001026	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
452863001027	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863001028	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
452863001029	tetramerization interface [polypeptide binding]; other site
452863001030	NAD(P) binding site [chemical binding]; other site
452863001031	catalytic residues [active]
452863001032	BCCT family transporter; Region: BCCT; pfam02028
452863001033	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
452863001034	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
452863001035	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
452863001036	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863001037	DNA-binding site [nucleotide binding]; DNA binding site
452863001038	FCD domain; Region: FCD; pfam07729
452863001039	Amino acid synthesis; Region: AA_synth; pfam06684
452863001040	Amino acid synthesis; Region: AA_synth; pfam06684
452863001041	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
452863001042	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863001043	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
452863001044	NAD(P) binding site [chemical binding]; other site
452863001045	catalytic residues [active]
452863001046	Tautomerase enzyme; Region: Tautomerase; pfam01361
452863001047	active site 1 [active]
452863001048	dimer interface [polypeptide binding]; other site
452863001049	hexamer interface [polypeptide binding]; other site
452863001050	active site 2 [active]
452863001051	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863001052	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863001053	aspartate aminotransferase; Provisional; Region: PRK05764
452863001054	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863001055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863001056	homodimer interface [polypeptide binding]; other site
452863001057	catalytic residue [active]
452863001058	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
452863001059	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
452863001060	dimerization interface [polypeptide binding]; other site
452863001061	ligand binding site [chemical binding]; other site
452863001062	NADP binding site [chemical binding]; other site
452863001063	catalytic site [active]
452863001064	hypothetical protein; Provisional; Region: PRK06834
452863001065	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863001066	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863001067	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863001068	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863001069	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863001070	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863001071	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
452863001072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
452863001073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
452863001074	hypothetical protein; Validated; Region: PRK06201
452863001075	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
452863001076	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
452863001077	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
452863001078	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
452863001079	Putative cyclase; Region: Cyclase; pfam04199
452863001080	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
452863001081	EamA-like transporter family; Region: EamA; pfam00892
452863001082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863001083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863001084	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
452863001085	dimerization interface [polypeptide binding]; other site
452863001086	substrate binding pocket [chemical binding]; other site
452863001087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001088	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863001089	putative substrate translocation pore; other site
452863001090	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863001091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863001092	DNA-binding site [nucleotide binding]; DNA binding site
452863001093	FCD domain; Region: FCD; pfam07729
452863001094	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863001095	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
452863001096	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863001097	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
452863001098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863001099	Walker A/P-loop; other site
452863001100	ATP binding site [chemical binding]; other site
452863001101	Q-loop/lid; other site
452863001102	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
452863001103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863001104	Walker A/P-loop; other site
452863001105	ATP binding site [chemical binding]; other site
452863001106	Q-loop/lid; other site
452863001107	ABC transporter signature motif; other site
452863001108	Walker B; other site
452863001109	D-loop; other site
452863001110	H-loop/switch region; other site
452863001111	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863001112	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
452863001113	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863001114	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
452863001115	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863001116	putative oxidoreductase; Provisional; Region: PRK11579
452863001117	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001118	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
452863001119	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
452863001120	putative ligand binding site [chemical binding]; other site
452863001121	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863001122	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
452863001123	TM-ABC transporter signature motif; other site
452863001124	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
452863001125	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863001126	Walker A/P-loop; other site
452863001127	ATP binding site [chemical binding]; other site
452863001128	Q-loop/lid; other site
452863001129	ABC transporter signature motif; other site
452863001130	Walker B; other site
452863001131	D-loop; other site
452863001132	H-loop/switch region; other site
452863001133	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001134	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001135	DNA binding site [nucleotide binding]
452863001136	domain linker motif; other site
452863001137	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863001138	ligand binding site [chemical binding]; other site
452863001139	dimerization interface [polypeptide binding]; other site
452863001140	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001141	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001142	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001143	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
452863001144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001145	putative substrate translocation pore; other site
452863001146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001147	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863001148	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001149	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001150	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001151	phosphoenolpyruvate synthase; Validated; Region: PRK06464
452863001152	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
452863001153	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
452863001154	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
452863001155	PEP synthetase regulatory protein; Provisional; Region: PRK05339
452863001156	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
452863001157	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
452863001158	TPR motif; other site
452863001159	Tetratricopeptide repeat; Region: TPR_12; pfam13424
452863001160	binding surface
452863001161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
452863001162	TPR motif; other site
452863001163	TPR repeat; Region: TPR_11; pfam13414
452863001164	binding surface
452863001165	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
452863001166	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
452863001167	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
452863001168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863001169	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863001170	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
452863001171	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
452863001172	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863001173	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863001174	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
452863001175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
452863001176	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
452863001177	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
452863001178	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
452863001179	ligand binding site [chemical binding]; other site
452863001180	NAD binding site [chemical binding]; other site
452863001181	catalytic site [active]
452863001182	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
452863001183	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
452863001184	inhibitor-cofactor binding pocket; inhibition site
452863001185	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863001186	catalytic residue [active]
452863001187	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863001188	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863001189	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
452863001190	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
452863001191	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
452863001192	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
452863001193	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
452863001194	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001195	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001196	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
452863001197	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863001198	dimer interface [polypeptide binding]; other site
452863001199	PYR/PP interface [polypeptide binding]; other site
452863001200	TPP binding site [chemical binding]; other site
452863001201	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863001202	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
452863001203	TPP-binding site [chemical binding]; other site
452863001204	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
452863001205	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
452863001206	NAD(P) binding site [chemical binding]; other site
452863001207	catalytic residues [active]
452863001208	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
452863001209	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
452863001210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863001211	catalytic residue [active]
452863001212	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001213	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001214	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001215	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863001216	classical (c) SDRs; Region: SDR_c; cd05233
452863001217	NAD(P) binding site [chemical binding]; other site
452863001218	active site
452863001219	dihydroxy-acid dehydratase; Validated; Region: PRK06131
452863001220	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
452863001221	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
452863001222	NAD binding site [chemical binding]; other site
452863001223	ligand binding site [chemical binding]; other site
452863001224	catalytic site [active]
452863001225	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
452863001226	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001227	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001228	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001229	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
452863001230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863001231	Walker A/P-loop; other site
452863001232	ATP binding site [chemical binding]; other site
452863001233	Q-loop/lid; other site
452863001234	ABC transporter signature motif; other site
452863001235	Walker B; other site
452863001236	D-loop; other site
452863001237	H-loop/switch region; other site
452863001238	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863001239	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
452863001240	TM-ABC transporter signature motif; other site
452863001241	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
452863001242	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863001243	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
452863001244	FAD binding domain; Region: FAD_binding_4; pfam01565
452863001245	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
452863001246	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863001247	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863001248	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
452863001249	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
452863001250	GAF domain; Region: GAF; pfam01590
452863001251	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
452863001252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863001253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863001254	dimer interface [polypeptide binding]; other site
452863001255	phosphorylation site [posttranslational modification]
452863001256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863001257	ATP binding site [chemical binding]; other site
452863001258	Mg2+ binding site [ion binding]; other site
452863001259	G-X-G motif; other site
452863001260	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
452863001261	active site
452863001262	putative catalytic site [active]
452863001263	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
452863001264	Fasciclin domain; Region: Fasciclin; pfam02469
452863001265	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
452863001266	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
452863001267	Moco binding site; other site
452863001268	metal coordination site [ion binding]; other site
452863001269	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
452863001270	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863001271	multiple promoter invertase; Provisional; Region: mpi; PRK13413
452863001272	catalytic residues [active]
452863001273	catalytic nucleophile [active]
452863001274	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863001275	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863001276	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863001277	Synaptic Site I dimer interface [polypeptide binding]; other site
452863001278	DNA binding site [nucleotide binding]
452863001279	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
452863001280	DNA-binding interface [nucleotide binding]; DNA binding site
452863001281	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863001282	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863001283	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863001284	Family description; Region: VCBS; pfam13517
452863001285	Family description; Region: VCBS; pfam13517
452863001286	Family description; Region: VCBS; pfam13517
452863001287	Family description; Region: VCBS; pfam13517
452863001288	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
452863001289	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863001290	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863001291	active site
452863001292	catalytic tetrad [active]
452863001293	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
452863001294	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
452863001295	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
452863001296	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
452863001297	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
452863001298	carboxyltransferase (CT) interaction site; other site
452863001299	biotinylation site [posttranslational modification]; other site
452863001300	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
452863001301	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
452863001302	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
452863001303	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863001304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001305	putative substrate translocation pore; other site
452863001306	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
452863001307	putative active site [active]
452863001308	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863001309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863001310	DNA-binding site [nucleotide binding]; DNA binding site
452863001311	FCD domain; Region: FCD; pfam07729
452863001312	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
452863001313	nucleoside/Zn binding site; other site
452863001314	dimer interface [polypeptide binding]; other site
452863001315	catalytic motif [active]
452863001316	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
452863001317	synthetase active site [active]
452863001318	NTP binding site [chemical binding]; other site
452863001319	metal binding site [ion binding]; metal-binding site
452863001320	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
452863001321	Zn binding site [ion binding]; other site
452863001322	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001323	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001324	DNA binding site [nucleotide binding]
452863001325	domain linker motif; other site
452863001326	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863001327	dimerization interface [polypeptide binding]; other site
452863001328	ligand binding site [chemical binding]; other site
452863001329	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
452863001330	active site
452863001331	tetramer interface [polypeptide binding]; other site
452863001332	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863001333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001334	putative substrate translocation pore; other site
452863001335	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863001336	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
452863001337	substrate binding site [chemical binding]; other site
452863001338	dimer interface [polypeptide binding]; other site
452863001339	ATP binding site [chemical binding]; other site
452863001340	Predicted permeases [General function prediction only]; Region: COG0679
452863001341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863001342	fructuronate transporter; Provisional; Region: PRK10034; cl15264
452863001343	fructuronate transporter; Provisional; Region: PRK10034; cl15264
452863001344	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
452863001345	CoA-transferase family III; Region: CoA_transf_3; pfam02515
452863001346	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
452863001347	active site
452863001348	catalytic residues [active]
452863001349	metal binding site [ion binding]; metal-binding site
452863001350	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
452863001351	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
452863001352	dimerization interface [polypeptide binding]; other site
452863001353	ligand binding site [chemical binding]; other site
452863001354	NADP binding site [chemical binding]; other site
452863001355	catalytic site [active]
452863001356	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
452863001357	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863001358	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863001359	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863001360	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
452863001361	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863001362	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863001363	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
452863001364	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863001365	putative substrate binding site [chemical binding]; other site
452863001366	putative ATP binding site [chemical binding]; other site
452863001367	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863001368	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
452863001369	putative homodimer interface [polypeptide binding]; other site
452863001370	putative homotetramer interface [polypeptide binding]; other site
452863001371	putative allosteric switch controlling residues; other site
452863001372	putative metal binding site [ion binding]; other site
452863001373	putative homodimer-homodimer interface [polypeptide binding]; other site
452863001374	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001375	active site residue [active]
452863001376	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
452863001377	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001378	active site residue [active]
452863001379	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001380	active site residue [active]
452863001381	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863001382	catalytic residues [active]
452863001383	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
452863001384	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001385	active site residue [active]
452863001386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001387	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863001388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863001390	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
452863001391	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
452863001392	active site
452863001393	NMT1-like family; Region: NMT1_2; pfam13379
452863001394	NMT1/THI5 like; Region: NMT1; pfam09084
452863001395	substrate binding pocket [chemical binding]; other site
452863001396	membrane-bound complex binding site; other site
452863001397	hinge residues; other site
452863001398	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
452863001399	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
452863001400	NADP binding site [chemical binding]; other site
452863001401	homodimer interface [polypeptide binding]; other site
452863001402	active site
452863001403	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
452863001404	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863001405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001406	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863001407	putative substrate translocation pore; other site
452863001408	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863001409	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863001410	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863001411	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863001412	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863001413	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
452863001414	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
452863001415	NAD binding site [chemical binding]; other site
452863001416	ligand binding site [chemical binding]; other site
452863001417	catalytic site [active]
452863001418	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
452863001419	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
452863001420	active site
452863001421	DNA binding site [nucleotide binding]
452863001422	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
452863001423	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
452863001424	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
452863001425	Catalytic site [active]
452863001426	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863001427	dimerization interface [polypeptide binding]; other site
452863001428	putative DNA binding site [nucleotide binding]; other site
452863001429	putative Zn2+ binding site [ion binding]; other site
452863001430	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
452863001431	amphipathic channel; other site
452863001432	Asn-Pro-Ala signature motifs; other site
452863001433	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
452863001434	Low molecular weight phosphatase family; Region: LMWPc; cd00115
452863001435	active site
452863001436	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
452863001437	stage V sporulation protein K; Region: spore_V_K; TIGR02881
452863001438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863001439	Walker A motif; other site
452863001440	ATP binding site [chemical binding]; other site
452863001441	Walker B motif; other site
452863001442	arginine finger; other site
452863001443	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863001444	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
452863001445	active site
452863001446	motif I; other site
452863001447	motif II; other site
452863001448	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
452863001449	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
452863001450	putative active site [active]
452863001451	catalytic site [active]
452863001452	putative metal binding site [ion binding]; other site
452863001453	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
452863001454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
452863001455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
452863001456	metal binding site [ion binding]; metal-binding site
452863001457	active site
452863001458	I-site; other site
452863001459	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
452863001460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863001461	dimer interface [polypeptide binding]; other site
452863001462	phosphorylation site [posttranslational modification]
452863001463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863001464	ATP binding site [chemical binding]; other site
452863001465	Mg2+ binding site [ion binding]; other site
452863001466	G-X-G motif; other site
452863001467	Methyltransferase domain; Region: Methyltransf_31; pfam13847
452863001468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863001469	S-adenosylmethionine binding site [chemical binding]; other site
452863001470	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
452863001471	short chain dehydrogenase; Provisional; Region: PRK06701
452863001472	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
452863001473	NAD binding site [chemical binding]; other site
452863001474	metal binding site [ion binding]; metal-binding site
452863001475	active site
452863001476	Domain of unknown function (DUF336); Region: DUF336; cl01249
452863001477	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001478	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001479	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
452863001480	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
452863001481	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863001482	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
452863001483	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001484	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001485	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863001486	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001487	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001488	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863001489	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863001490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001491	dimer interface [polypeptide binding]; other site
452863001492	conserved gate region; other site
452863001493	putative PBP binding loops; other site
452863001494	ABC-ATPase subunit interface; other site
452863001495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001496	putative PBP binding loops; other site
452863001497	dimer interface [polypeptide binding]; other site
452863001498	ABC-ATPase subunit interface; other site
452863001499	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863001500	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863001501	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863001502	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
452863001503	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863001504	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
452863001505	nucleotide binding site [chemical binding]; other site
452863001506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863001507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863001508	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
452863001509	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
452863001510	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
452863001511	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
452863001512	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
452863001513	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
452863001514	active site
452863001515	catalytic triad [active]
452863001516	oxyanion hole [active]
452863001517	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
452863001518	malonic semialdehyde reductase; Provisional; Region: PRK05365
452863001519	FMN binding site [chemical binding]; other site
452863001520	dimer interface [polypeptide binding]; other site
452863001521	phosphoglucomutase; Validated; Region: PRK07564
452863001522	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
452863001523	active site
452863001524	substrate binding site [chemical binding]; other site
452863001525	metal binding site [ion binding]; metal-binding site
452863001526	Nuclease-related domain; Region: NERD; pfam08378
452863001527	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
452863001528	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863001529	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863001530	dimerization interface [polypeptide binding]; other site
452863001531	Lysine efflux permease [General function prediction only]; Region: COG1279
452863001532	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
452863001533	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863001534	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863001535	DNA-binding site [nucleotide binding]; DNA binding site
452863001536	FCD domain; Region: FCD; pfam07729
452863001537	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
452863001538	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
452863001539	CoA-transferase family III; Region: CoA_transf_3; pfam02515
452863001540	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
452863001541	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
452863001542	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
452863001543	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
452863001544	Amidase; Region: Amidase; cl11426
452863001545	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001546	active site residue [active]
452863001547	Prephenate dehydratase; Region: PDT; pfam00800
452863001548	prephenate dehydratase; Provisional; Region: PRK11898
452863001549	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
452863001550	putative L-Phe binding site [chemical binding]; other site
452863001551	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
452863001552	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
452863001553	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
452863001554	seryl-tRNA synthetase; Provisional; Region: PRK05431
452863001555	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
452863001556	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
452863001557	dimer interface [polypeptide binding]; other site
452863001558	active site
452863001559	motif 1; other site
452863001560	motif 2; other site
452863001561	motif 3; other site
452863001562	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863001563	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863001564	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
452863001565	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
452863001566	dimer interface [polypeptide binding]; other site
452863001567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863001568	catalytic residue [active]
452863001569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001570	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863001571	active site residue [active]
452863001572	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863001573	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
452863001574	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
452863001575	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
452863001576	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
452863001577	active site
452863001578	non-prolyl cis peptide bond; other site
452863001579	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
452863001580	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
452863001581	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863001582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001583	dimer interface [polypeptide binding]; other site
452863001584	conserved gate region; other site
452863001585	putative PBP binding loops; other site
452863001586	ABC-ATPase subunit interface; other site
452863001587	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863001588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001589	ABC-ATPase subunit interface; other site
452863001590	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
452863001591	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863001592	Walker A/P-loop; other site
452863001593	ATP binding site [chemical binding]; other site
452863001594	Q-loop/lid; other site
452863001595	ABC transporter signature motif; other site
452863001596	Walker B; other site
452863001597	D-loop; other site
452863001598	H-loop/switch region; other site
452863001599	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863001600	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863001601	Walker A/P-loop; other site
452863001602	ATP binding site [chemical binding]; other site
452863001603	Q-loop/lid; other site
452863001604	ABC transporter signature motif; other site
452863001605	Walker B; other site
452863001606	D-loop; other site
452863001607	H-loop/switch region; other site
452863001608	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863001609	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
452863001610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863001611	active site
452863001612	motif I; other site
452863001613	motif II; other site
452863001614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863001615	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863001616	catalytic core [active]
452863001617	putative phosphoketolase; Provisional; Region: PRK05261
452863001618	XFP N-terminal domain; Region: XFP_N; pfam09364
452863001619	XFP C-terminal domain; Region: XFP_C; pfam09363
452863001620	Protein of unknown function (DUF429); Region: DUF429; pfam04250
452863001621	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
452863001622	substrate binding pocket [chemical binding]; other site
452863001623	catalytic triad [active]
452863001624	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
452863001625	dimer interface [polypeptide binding]; other site
452863001626	substrate binding site [chemical binding]; other site
452863001627	metal binding sites [ion binding]; metal-binding site
452863001628	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
452863001629	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
452863001630	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
452863001631	putative hydrolase; Region: TIGR03624
452863001632	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
452863001633	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
452863001634	Ligand Binding Site [chemical binding]; other site
452863001635	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863001636	active site
452863001637	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863001638	active site
452863001639	metal binding site [ion binding]; metal-binding site
452863001640	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863001641	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001642	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001643	DNA binding site [nucleotide binding]
452863001644	domain linker motif; other site
452863001645	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863001646	putative dimerization interface [polypeptide binding]; other site
452863001647	putative ligand binding site [chemical binding]; other site
452863001648	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
452863001649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863001650	Walker A motif; other site
452863001651	ATP binding site [chemical binding]; other site
452863001652	Walker B motif; other site
452863001653	arginine finger; other site
452863001654	Peptidase family M41; Region: Peptidase_M41; pfam01434
452863001655	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
452863001656	homodecamer interface [polypeptide binding]; other site
452863001657	GTP cyclohydrolase I; Provisional; Region: PLN03044
452863001658	active site
452863001659	putative catalytic site residues [active]
452863001660	zinc binding site [ion binding]; other site
452863001661	GTP-CH-I/GFRP interaction surface; other site
452863001662	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
452863001663	dihydropteroate synthase; Region: DHPS; TIGR01496
452863001664	substrate binding pocket [chemical binding]; other site
452863001665	dimer interface [polypeptide binding]; other site
452863001666	inhibitor binding site; inhibition site
452863001667	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
452863001668	homooctamer interface [polypeptide binding]; other site
452863001669	active site
452863001670	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
452863001671	catalytic center binding site [active]
452863001672	ATP binding site [chemical binding]; other site
452863001673	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
452863001674	Uncharacterized conserved protein [Function unknown]; Region: COG3402
452863001675	Bacterial PH domain; Region: DUF304; pfam03703
452863001676	Bacterial PH domain; Region: DUF304; pfam03703
452863001677	Bacterial PH domain; Region: DUF304; pfam03703
452863001678	Rossmann-like domain; Region: Rossmann-like; pfam10727
452863001679	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
452863001680	Pantoate-beta-alanine ligase; Region: PanC; cd00560
452863001681	pantoate--beta-alanine ligase; Region: panC; TIGR00018
452863001682	active site
452863001683	ATP-binding site [chemical binding]; other site
452863001684	pantoate-binding site; other site
452863001685	HXXH motif; other site
452863001686	Domain of unknown function (DUF222); Region: DUF222; pfam02720
452863001687	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863001688	active site
452863001689	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
452863001690	intracellular protease, PfpI family; Region: PfpI; TIGR01382
452863001691	proposed catalytic triad [active]
452863001692	conserved cys residue [active]
452863001693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001694	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863001695	putative substrate translocation pore; other site
452863001696	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863001697	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863001698	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
452863001699	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
452863001700	putative anticodon binding site; other site
452863001701	dimer interface [polypeptide binding]; other site
452863001702	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
452863001703	motif 1; other site
452863001704	dimer interface [polypeptide binding]; other site
452863001705	active site
452863001706	motif 2; other site
452863001707	motif 3; other site
452863001708	Lsr2; Region: Lsr2; pfam11774
452863001709	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
452863001710	Clp amino terminal domain; Region: Clp_N; pfam02861
452863001711	Clp amino terminal domain; Region: Clp_N; pfam02861
452863001712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863001713	Walker A motif; other site
452863001714	ATP binding site [chemical binding]; other site
452863001715	Walker B motif; other site
452863001716	arginine finger; other site
452863001717	UvrB/uvrC motif; Region: UVR; pfam02151
452863001718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863001719	Walker A motif; other site
452863001720	ATP binding site [chemical binding]; other site
452863001721	Walker B motif; other site
452863001722	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
452863001723	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863001724	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863001725	N-acetylglutamate synthase; Validated; Region: PRK07922
452863001726	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
452863001727	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
452863001728	DAK2 domain; Region: Dak2; cl03685
452863001729	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
452863001730	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
452863001731	dimerization domain swap beta strand [polypeptide binding]; other site
452863001732	regulatory protein interface [polypeptide binding]; other site
452863001733	active site
452863001734	regulatory phosphorylation site [posttranslational modification]; other site
452863001735	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
452863001736	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
452863001737	minor groove reading motif; other site
452863001738	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
452863001739	helix-hairpin-helix signature motif; other site
452863001740	active site
452863001741	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
452863001742	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
452863001743	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
452863001744	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
452863001745	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
452863001746	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
452863001747	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
452863001748	G1 box; other site
452863001749	putative GEF interaction site [polypeptide binding]; other site
452863001750	GTP/Mg2+ binding site [chemical binding]; other site
452863001751	Switch I region; other site
452863001752	G2 box; other site
452863001753	G3 box; other site
452863001754	Switch II region; other site
452863001755	G4 box; other site
452863001756	G5 box; other site
452863001757	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
452863001758	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
452863001759	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
452863001760	dimer interface [polypeptide binding]; other site
452863001761	active site
452863001762	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
452863001763	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
452863001764	active site
452863001765	tetramer interface [polypeptide binding]; other site
452863001766	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
452863001767	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
452863001768	dimer interface [polypeptide binding]; other site
452863001769	NADP binding site [chemical binding]; other site
452863001770	catalytic residues [active]
452863001771	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
452863001772	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
452863001773	putative active site [active]
452863001774	catalytic residue [active]
452863001775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863001776	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
452863001777	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
452863001778	putative dimerization interface [polypeptide binding]; other site
452863001779	putative substrate binding pocket [chemical binding]; other site
452863001780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
452863001781	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
452863001782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
452863001783	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863001784	Ligand Binding Site [chemical binding]; other site
452863001785	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
452863001786	nudix motif; other site
452863001787	DNA repair protein RadA; Provisional; Region: PRK11823
452863001788	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
452863001789	Walker A motif; other site
452863001790	ATP binding site [chemical binding]; other site
452863001791	Walker B motif; other site
452863001792	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
452863001793	Predicted membrane protein [Function unknown]; Region: COG4129
452863001794	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
452863001795	PBP superfamily domain; Region: PBP_like_2; cl17296
452863001796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001797	dimer interface [polypeptide binding]; other site
452863001798	conserved gate region; other site
452863001799	putative PBP binding loops; other site
452863001800	ABC-ATPase subunit interface; other site
452863001801	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
452863001802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001803	dimer interface [polypeptide binding]; other site
452863001804	conserved gate region; other site
452863001805	putative PBP binding loops; other site
452863001806	ABC-ATPase subunit interface; other site
452863001807	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
452863001808	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
452863001809	Walker A/P-loop; other site
452863001810	ATP binding site [chemical binding]; other site
452863001811	Q-loop/lid; other site
452863001812	ABC transporter signature motif; other site
452863001813	Walker B; other site
452863001814	D-loop; other site
452863001815	H-loop/switch region; other site
452863001816	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
452863001817	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
452863001818	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
452863001819	active site
452863001820	oxyanion hole [active]
452863001821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001823	DNA binding site [nucleotide binding]
452863001824	domain linker motif; other site
452863001825	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
452863001826	ligand binding site [chemical binding]; other site
452863001827	dimerization interface (open form) [polypeptide binding]; other site
452863001828	dimerization interface (closed form) [polypeptide binding]; other site
452863001829	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
452863001830	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
452863001831	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
452863001832	active site
452863001833	catalytic site [active]
452863001834	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
452863001835	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863001836	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863001837	DNA binding residues [nucleotide binding]
452863001838	RibD C-terminal domain; Region: RibD_C; cl17279
452863001839	ribulokinase; Provisional; Region: PRK04123
452863001840	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
452863001841	N- and C-terminal domain interface [polypeptide binding]; other site
452863001842	active site
452863001843	MgATP binding site [chemical binding]; other site
452863001844	catalytic site [active]
452863001845	metal binding site [ion binding]; metal-binding site
452863001846	carbohydrate binding site [chemical binding]; other site
452863001847	homodimer interface [polypeptide binding]; other site
452863001848	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
452863001849	intersubunit interface [polypeptide binding]; other site
452863001850	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
452863001851	active site
452863001852	Zn2+ binding site [ion binding]; other site
452863001853	L-arabinose isomerase; Provisional; Region: PRK02929
452863001854	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
452863001855	hexamer (dimer of trimers) interface [polypeptide binding]; other site
452863001856	trimer interface [polypeptide binding]; other site
452863001857	substrate binding site [chemical binding]; other site
452863001858	Mn binding site [ion binding]; other site
452863001859	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863001860	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
452863001861	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
452863001862	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
452863001863	minor groove reading motif; other site
452863001864	helix-hairpin-helix signature motif; other site
452863001865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001867	DNA binding site [nucleotide binding]
452863001868	domain linker motif; other site
452863001869	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863001870	dimerization interface [polypeptide binding]; other site
452863001871	ligand binding site [chemical binding]; other site
452863001872	GTPase RsgA; Reviewed; Region: PRK01889
452863001873	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
452863001874	RNA binding site [nucleotide binding]; other site
452863001875	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
452863001876	GTPase/Zn-binding domain interface [polypeptide binding]; other site
452863001877	GTP/Mg2+ binding site [chemical binding]; other site
452863001878	G4 box; other site
452863001879	G5 box; other site
452863001880	G1 box; other site
452863001881	Switch I region; other site
452863001882	G2 box; other site
452863001883	G3 box; other site
452863001884	Switch II region; other site
452863001885	H+ Antiporter protein; Region: 2A0121; TIGR00900
452863001886	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
452863001887	alpha-gamma subunit interface [polypeptide binding]; other site
452863001888	beta-gamma subunit interface [polypeptide binding]; other site
452863001889	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
452863001890	gamma-beta subunit interface [polypeptide binding]; other site
452863001891	alpha-beta subunit interface [polypeptide binding]; other site
452863001892	urease subunit alpha; Reviewed; Region: ureC; PRK13207
452863001893	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
452863001894	subunit interactions [polypeptide binding]; other site
452863001895	active site
452863001896	flap region; other site
452863001897	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
452863001898	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
452863001899	dimer interface [polypeptide binding]; other site
452863001900	catalytic residues [active]
452863001901	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
452863001902	UreF; Region: UreF; pfam01730
452863001903	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863001904	UreD urease accessory protein; Region: UreD; cl00530
452863001905	High-affinity nickel-transport protein; Region: NicO; cl00964
452863001906	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863001907	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863001908	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863001909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001910	ABC-ATPase subunit interface; other site
452863001911	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863001912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001913	dimer interface [polypeptide binding]; other site
452863001914	conserved gate region; other site
452863001915	putative PBP binding loops; other site
452863001916	ABC-ATPase subunit interface; other site
452863001917	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
452863001918	beta-galactosidase; Region: BGL; TIGR03356
452863001919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863001920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863001921	DNA binding site [nucleotide binding]
452863001922	domain linker motif; other site
452863001923	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
452863001924	putative dimerization interface [polypeptide binding]; other site
452863001925	putative ligand binding site [chemical binding]; other site
452863001926	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
452863001927	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863001928	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863001929	DNA-binding site [nucleotide binding]; DNA binding site
452863001930	FCD domain; Region: FCD; pfam07729
452863001931	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
452863001932	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
452863001933	PYR/PP interface [polypeptide binding]; other site
452863001934	dimer interface [polypeptide binding]; other site
452863001935	TPP binding site [chemical binding]; other site
452863001936	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863001937	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
452863001938	TPP-binding site [chemical binding]; other site
452863001939	dimer interface [polypeptide binding]; other site
452863001940	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863001941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863001942	putative substrate translocation pore; other site
452863001943	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863001944	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863001945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863001946	NAD(P) binding site [chemical binding]; other site
452863001947	active site
452863001948	dihydroxyacetone kinase; Provisional; Region: PRK14479
452863001949	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
452863001950	DAK2 domain; Region: Dak2; pfam02734
452863001951	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
452863001952	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
452863001953	putative hydrophobic ligand binding site [chemical binding]; other site
452863001954	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
452863001955	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
452863001956	substrate binding pocket [chemical binding]; other site
452863001957	catalytic triad [active]
452863001958	GAF domain; Region: GAF; pfam01590
452863001959	GAF domain; Region: GAF_2; pfam13185
452863001960	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863001961	Predicted ATPase [General function prediction only]; Region: COG3910
452863001962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863001963	Walker A/P-loop; other site
452863001964	ATP binding site [chemical binding]; other site
452863001965	Q-loop/lid; other site
452863001966	ABC transporter signature motif; other site
452863001967	Walker B; other site
452863001968	D-loop; other site
452863001969	H-loop/switch region; other site
452863001970	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
452863001971	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
452863001972	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
452863001973	beta-galactosidase; Region: BGL; TIGR03356
452863001974	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
452863001975	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
452863001976	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863001977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001978	dimer interface [polypeptide binding]; other site
452863001979	conserved gate region; other site
452863001980	putative PBP binding loops; other site
452863001981	ABC-ATPase subunit interface; other site
452863001982	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
452863001983	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863001984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863001985	dimer interface [polypeptide binding]; other site
452863001986	conserved gate region; other site
452863001987	putative PBP binding loops; other site
452863001988	ABC-ATPase subunit interface; other site
452863001989	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
452863001990	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863001991	Walker A/P-loop; other site
452863001992	ATP binding site [chemical binding]; other site
452863001993	Q-loop/lid; other site
452863001994	ABC transporter signature motif; other site
452863001995	Walker B; other site
452863001996	D-loop; other site
452863001997	H-loop/switch region; other site
452863001998	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863001999	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
452863002000	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863002001	Walker A/P-loop; other site
452863002002	ATP binding site [chemical binding]; other site
452863002003	Q-loop/lid; other site
452863002004	ABC transporter signature motif; other site
452863002005	Walker B; other site
452863002006	D-loop; other site
452863002007	H-loop/switch region; other site
452863002008	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863002009	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
452863002010	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
452863002011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002012	S-adenosylmethionine binding site [chemical binding]; other site
452863002013	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
452863002014	inhibitor binding site; inhibition site
452863002015	active site
452863002016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863002017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863002018	LysR substrate binding domain; Region: LysR_substrate; pfam03466
452863002019	dimerization interface [polypeptide binding]; other site
452863002020	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
452863002021	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
452863002022	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863002023	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863002024	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863002025	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
452863002026	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
452863002027	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
452863002028	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863002029	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
452863002030	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
452863002031	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
452863002032	SnoaL-like domain; Region: SnoaL_2; pfam12680
452863002033	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
452863002034	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
452863002035	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
452863002036	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
452863002037	tartrate dehydrogenase; Region: TTC; TIGR02089
452863002038	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863002039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863002040	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
452863002041	dimerization interface [polypeptide binding]; other site
452863002042	Predicted membrane protein [Function unknown]; Region: COG3462
452863002043	Short C-terminal domain; Region: SHOCT; pfam09851
452863002044	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
452863002045	Sodium Bile acid symporter family; Region: SBF; pfam01758
452863002046	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
452863002047	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
452863002048	active site
452863002049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863002050	peptide synthase; Provisional; Region: PRK09274
452863002051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863002052	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863002053	acyl-activating enzyme (AAE) consensus motif; other site
452863002054	AMP binding site [chemical binding]; other site
452863002055	active site
452863002056	CoA binding site [chemical binding]; other site
452863002057	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863002058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002059	NAD(P) binding site [chemical binding]; other site
452863002060	active site
452863002061	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
452863002062	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863002063	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
452863002064	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863002065	hypothetical protein; Provisional; Region: PRK06126
452863002066	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863002067	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
452863002068	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
452863002069	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
452863002070	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
452863002071	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
452863002072	trimer interface [polypeptide binding]; other site
452863002073	active site
452863002074	substrate binding site [chemical binding]; other site
452863002075	CoA binding site [chemical binding]; other site
452863002076	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863002077	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863002078	aspartate aminotransferase; Provisional; Region: PRK06107
452863002079	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863002080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863002081	homodimer interface [polypeptide binding]; other site
452863002082	catalytic residue [active]
452863002083	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
452863002084	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
452863002085	Helix-turn-helix domain; Region: HTH_38; pfam13936
452863002086	Integrase core domain; Region: rve; pfam00665
452863002087	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
452863002088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863002089	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
452863002090	putative dimerization interface [polypeptide binding]; other site
452863002091	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
452863002092	putative active site [active]
452863002093	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
452863002094	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
452863002095	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
452863002096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002097	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863002098	putative substrate translocation pore; other site
452863002099	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
452863002100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002101	NAD(P) binding site [chemical binding]; other site
452863002102	active site
452863002103	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
452863002104	putative ligand binding site [chemical binding]; other site
452863002105	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
452863002106	putative NAD binding site [chemical binding]; other site
452863002107	catalytic site [active]
452863002108	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
452863002109	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
452863002110	NADP binding site [chemical binding]; other site
452863002111	homodimer interface [polypeptide binding]; other site
452863002112	active site
452863002113	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
452863002114	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
452863002115	putative NAD(P) binding site [chemical binding]; other site
452863002116	catalytic Zn binding site [ion binding]; other site
452863002117	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
452863002118	ATP-binding site [chemical binding]; other site
452863002119	Gluconate-6-phosphate binding site [chemical binding]; other site
452863002120	Shikimate kinase; Region: SKI; pfam01202
452863002121	EamA-like transporter family; Region: EamA; pfam00892
452863002122	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863002123	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863002124	active site
452863002125	catalytic tetrad [active]
452863002126	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
452863002127	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
452863002128	NmrA-like family; Region: NmrA; pfam05368
452863002129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002130	NAD(P) binding site [chemical binding]; other site
452863002131	active site
452863002132	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
452863002133	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
452863002134	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
452863002135	active site
452863002136	catalytic site [active]
452863002137	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
452863002138	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
452863002139	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
452863002140	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
452863002141	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
452863002142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002143	S-adenosylmethionine binding site [chemical binding]; other site
452863002144	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863002145	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863002146	active site
452863002147	catalytic tetrad [active]
452863002148	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
452863002149	metal binding site [ion binding]; metal-binding site
452863002150	active site
452863002151	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
452863002152	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863002153	putative NAD(P) binding site [chemical binding]; other site
452863002154	active site
452863002155	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863002156	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863002157	active site
452863002158	catalytic tetrad [active]
452863002159	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863002160	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863002161	active site
452863002162	catalytic tetrad [active]
452863002163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863002164	salt bridge; other site
452863002165	non-specific DNA binding site [nucleotide binding]; other site
452863002166	sequence-specific DNA binding site [nucleotide binding]; other site
452863002167	Dodecin; Region: Dodecin; pfam07311
452863002168	Amb_all domain; Region: Amb_all; smart00656
452863002169	Amb_all domain; Region: Amb_all; smart00656
452863002170	Pectinesterase; Region: Pectinesterase; pfam01095
452863002171	putative pectinesterase; Region: PLN02432; cl01911
452863002172	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863002173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002174	dimer interface [polypeptide binding]; other site
452863002175	conserved gate region; other site
452863002176	putative PBP binding loops; other site
452863002177	ABC-ATPase subunit interface; other site
452863002178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002179	dimer interface [polypeptide binding]; other site
452863002180	conserved gate region; other site
452863002181	putative PBP binding loops; other site
452863002182	ABC-ATPase subunit interface; other site
452863002183	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863002184	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863002185	Methane oxygenase PmoA; Region: PmoA; pfam14100
452863002186	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
452863002187	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
452863002188	active site
452863002189	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863002190	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863002191	DNA binding site [nucleotide binding]
452863002192	domain linker motif; other site
452863002193	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863002194	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863002195	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863002196	DNA-binding site [nucleotide binding]; DNA binding site
452863002197	FCD domain; Region: FCD; pfam07729
452863002198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
452863002199	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
452863002200	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863002201	putative transporter; Provisional; Region: PRK09821
452863002202	GntP family permease; Region: GntP_permease; pfam02447
452863002203	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
452863002204	active site
452863002205	intersubunit interface [polypeptide binding]; other site
452863002206	zinc binding site [ion binding]; other site
452863002207	Na+ binding site [ion binding]; other site
452863002208	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
452863002209	Predicted acetyltransferase [General function prediction only]; Region: COG2388
452863002210	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863002211	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863002212	catalytic residue [active]
452863002213	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
452863002214	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863002215	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
452863002216	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
452863002217	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
452863002218	IucA / IucC family; Region: IucA_IucC; pfam04183
452863002219	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
452863002220	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
452863002221	classical (c) SDRs; Region: SDR_c; cd05233
452863002222	NAD(P) binding site [chemical binding]; other site
452863002223	active site
452863002224	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
452863002225	proline/glycine betaine transporter; Provisional; Region: PRK10642
452863002226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002227	putative substrate translocation pore; other site
452863002228	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
452863002229	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
452863002230	nucleotide binding site [chemical binding]; other site
452863002231	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
452863002232	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
452863002233	active site
452863002234	DNA binding site [nucleotide binding]
452863002235	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
452863002236	DNA binding site [nucleotide binding]
452863002237	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
452863002238	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
452863002239	putative DNA binding site [nucleotide binding]; other site
452863002240	putative homodimer interface [polypeptide binding]; other site
452863002241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002242	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
452863002243	hydrophobic ligand binding site; other site
452863002244	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
452863002245	dimerization domain swap beta strand [polypeptide binding]; other site
452863002246	regulatory protein interface [polypeptide binding]; other site
452863002247	active site
452863002248	regulatory phosphorylation site [posttranslational modification]; other site
452863002249	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
452863002250	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
452863002251	active site
452863002252	phosphorylation site [posttranslational modification]
452863002253	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
452863002254	active site
452863002255	P-loop; other site
452863002256	phosphorylation site [posttranslational modification]
452863002257	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
452863002258	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
452863002259	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
452863002260	putative substrate binding site [chemical binding]; other site
452863002261	putative ATP binding site [chemical binding]; other site
452863002262	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
452863002263	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
452863002264	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
452863002265	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
452863002266	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
452863002267	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863002268	motif II; other site
452863002269	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
452863002270	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
452863002271	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
452863002272	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
452863002273	H+ Antiporter protein; Region: 2A0121; TIGR00900
452863002274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002275	lipoyl synthase; Provisional; Region: PRK05481
452863002276	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863002277	FeS/SAM binding site; other site
452863002278	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
452863002279	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
452863002280	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
452863002281	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
452863002282	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
452863002283	dimer interface [polypeptide binding]; other site
452863002284	active site
452863002285	glycine-pyridoxal phosphate binding site [chemical binding]; other site
452863002286	folate binding site [chemical binding]; other site
452863002287	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
452863002288	lipoyl attachment site [posttranslational modification]; other site
452863002289	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
452863002290	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863002291	glycine dehydrogenase; Provisional; Region: PRK05367
452863002292	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
452863002293	tetramer interface [polypeptide binding]; other site
452863002294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863002295	catalytic residue [active]
452863002296	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
452863002297	tetramer interface [polypeptide binding]; other site
452863002298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863002299	catalytic residue [active]
452863002300	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
452863002301	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
452863002302	putative active site [active]
452863002303	Protein of unknown function (DUF445); Region: DUF445; pfam04286
452863002304	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
452863002305	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
452863002306	active site
452863002307	catalytic site [active]
452863002308	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
452863002309	CoA-transferase family III; Region: CoA_transf_3; pfam02515
452863002310	Predicted membrane protein [Function unknown]; Region: COG4270
452863002311	AzlC protein; Region: AzlC; pfam03591
452863002312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863002313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002314	Domain of unknown function DUF77; Region: DUF77; pfam01910
452863002315	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
452863002316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
452863002317	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
452863002318	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
452863002319	dimerization interface [polypeptide binding]; other site
452863002320	DPS ferroxidase diiron center [ion binding]; other site
452863002321	ion pore; other site
452863002322	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
452863002323	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863002324	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
452863002325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002326	S-adenosylmethionine binding site [chemical binding]; other site
452863002327	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
452863002328	active site
452863002329	DNA polymerase delta, subunit 4; Region: DNA_pol_delta_4; pfam04081
452863002330	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
452863002331	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
452863002332	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
452863002333	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863002334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002335	NAD(P) binding site [chemical binding]; other site
452863002336	active site
452863002337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863002338	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
452863002339	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863002340	DNA binding residues [nucleotide binding]
452863002341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863002342	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
452863002343	active site
452863002344	motif I; other site
452863002345	motif II; other site
452863002346	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
452863002347	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
452863002348	putative active site [active]
452863002349	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
452863002350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863002351	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
452863002352	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
452863002353	putative ADP-binding pocket [chemical binding]; other site
452863002354	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
452863002355	dimer interface [polypeptide binding]; other site
452863002356	active site
452863002357	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
452863002358	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
452863002359	substrate binding site [chemical binding]; other site
452863002360	ATP binding site [chemical binding]; other site
452863002361	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
452863002362	active site
452863002363	HIGH motif; other site
452863002364	nucleotide binding site [chemical binding]; other site
452863002365	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
452863002366	classical (c) SDRs; Region: SDR_c; cd05233
452863002367	NAD(P) binding site [chemical binding]; other site
452863002368	active site
452863002369	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863002370	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
452863002371	NAD(P) binding site [chemical binding]; other site
452863002372	catalytic residues [active]
452863002373	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
452863002374	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
452863002375	substrate binding site [chemical binding]; other site
452863002376	ATP binding site [chemical binding]; other site
452863002377	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
452863002378	active site
452863002379	nucleotide binding site [chemical binding]; other site
452863002380	HIGH motif; other site
452863002381	KMSKS motif; other site
452863002382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002383	S-adenosylmethionine binding site [chemical binding]; other site
452863002384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863002385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863002386	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863002387	dimerization interface [polypeptide binding]; other site
452863002388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002389	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863002390	putative substrate translocation pore; other site
452863002391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002392	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
452863002393	NAD(P) binding site [chemical binding]; other site
452863002394	active site
452863002395	Predicted transcriptional regulators [Transcription]; Region: COG1733
452863002396	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
452863002397	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
452863002398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002399	NAD(P) binding site [chemical binding]; other site
452863002400	active site
452863002401	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
452863002402	putative proline-specific permease; Provisional; Region: proY; PRK10580
452863002403	Spore germination protein; Region: Spore_permease; cl17796
452863002404	Domain of unknown function (DUF222); Region: DUF222; pfam02720
452863002405	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863002406	active site
452863002407	Protein of unknown function (DUF664); Region: DUF664; pfam04978
452863002408	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
452863002409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863002410	S-adenosylmethionine binding site [chemical binding]; other site
452863002411	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863002412	putative DNA binding site [nucleotide binding]; other site
452863002413	dimerization interface [polypeptide binding]; other site
452863002414	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863002415	putative Zn2+ binding site [ion binding]; other site
452863002416	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863002417	urocanate hydratase; Provisional; Region: PRK05414
452863002418	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
452863002419	active sites [active]
452863002420	tetramer interface [polypeptide binding]; other site
452863002421	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863002422	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863002423	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863002424	Ligand Binding Site [chemical binding]; other site
452863002425	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
452863002426	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
452863002427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
452863002428	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
452863002429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
452863002430	putative active site [active]
452863002431	heme pocket [chemical binding]; other site
452863002432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863002433	ATP binding site [chemical binding]; other site
452863002434	Mg2+ binding site [ion binding]; other site
452863002435	G-X-G motif; other site
452863002436	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
452863002437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863002438	active site
452863002439	phosphorylation site [posttranslational modification]
452863002440	intermolecular recognition site; other site
452863002441	dimerization interface [polypeptide binding]; other site
452863002442	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
452863002443	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
452863002444	putative active site [active]
452863002445	putative metal binding site [ion binding]; other site
452863002446	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
452863002447	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
452863002448	CopC domain; Region: CopC; pfam04234
452863002449	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863002450	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863002451	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863002452	Ligand Binding Site [chemical binding]; other site
452863002453	phosphoenolpyruvate synthase; Validated; Region: PRK06241
452863002454	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
452863002455	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
452863002456	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
452863002457	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
452863002458	Walker A/P-loop; other site
452863002459	ATP binding site [chemical binding]; other site
452863002460	Q-loop/lid; other site
452863002461	ABC transporter signature motif; other site
452863002462	Walker B; other site
452863002463	D-loop; other site
452863002464	H-loop/switch region; other site
452863002465	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
452863002466	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
452863002467	NlpC/P60 family; Region: NLPC_P60; pfam00877
452863002468	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
452863002469	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
452863002470	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
452863002471	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
452863002472	EamA-like transporter family; Region: EamA; pfam00892
452863002473	EamA-like transporter family; Region: EamA; pfam00892
452863002474	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
452863002475	catalytic residues [active]
452863002476	hypothetical protein; Provisional; Region: PRK07945
452863002477	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
452863002478	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
452863002479	active site
452863002480	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
452863002481	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863002482	putative active site [active]
452863002483	putative metal binding site [ion binding]; other site
452863002484	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
452863002485	active site
452863002486	Asp23 family; Region: Asp23; pfam03780
452863002487	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
452863002488	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
452863002489	active site
452863002490	catalytic site [active]
452863002491	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863002492	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863002493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002494	dimer interface [polypeptide binding]; other site
452863002495	conserved gate region; other site
452863002496	putative PBP binding loops; other site
452863002497	ABC-ATPase subunit interface; other site
452863002498	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863002499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002500	dimer interface [polypeptide binding]; other site
452863002501	conserved gate region; other site
452863002502	putative PBP binding loops; other site
452863002503	ABC-ATPase subunit interface; other site
452863002504	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863002505	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863002506	DNA binding site [nucleotide binding]
452863002507	domain linker motif; other site
452863002508	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863002509	dimerization interface [polypeptide binding]; other site
452863002510	ligand binding site [chemical binding]; other site
452863002511	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
452863002512	putative catalytic site [active]
452863002513	putative phosphate binding site [ion binding]; other site
452863002514	active site
452863002515	metal binding site A [ion binding]; metal-binding site
452863002516	DNA binding site [nucleotide binding]
452863002517	putative AP binding site [nucleotide binding]; other site
452863002518	putative metal binding site B [ion binding]; other site
452863002519	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
452863002520	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
452863002521	tetrameric interface [polypeptide binding]; other site
452863002522	NAD binding site [chemical binding]; other site
452863002523	catalytic residues [active]
452863002524	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
452863002525	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863002526	substrate binding site [chemical binding]; other site
452863002527	oxyanion hole (OAH) forming residues; other site
452863002528	trimer interface [polypeptide binding]; other site
452863002529	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
452863002530	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863002531	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
452863002532	enoyl-CoA hydratase; Provisional; Region: PRK05862
452863002533	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863002534	substrate binding site [chemical binding]; other site
452863002535	oxyanion hole (OAH) forming residues; other site
452863002536	trimer interface [polypeptide binding]; other site
452863002537	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
452863002538	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
452863002539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863002540	non-specific DNA binding site [nucleotide binding]; other site
452863002541	salt bridge; other site
452863002542	sequence-specific DNA binding site [nucleotide binding]; other site
452863002543	Cupin domain; Region: Cupin_2; pfam07883
452863002544	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863002545	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
452863002546	Transcriptional regulators [Transcription]; Region: MarR; COG1846
452863002547	MarR family; Region: MarR; pfam01047
452863002548	acyl-coenzyme A oxidase; Region: PLN02526
452863002549	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863002550	active site
452863002551	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
452863002552	DNA binding residues [nucleotide binding]
452863002553	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863002554	dimer interface [polypeptide binding]; other site
452863002555	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
452863002556	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863002557	DNA-binding site [nucleotide binding]; DNA binding site
452863002558	RNA-binding motif; other site
452863002559	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863002560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863002561	active site
452863002562	phosphorylation site [posttranslational modification]
452863002563	intermolecular recognition site; other site
452863002564	dimerization interface [polypeptide binding]; other site
452863002565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863002566	DNA binding residues [nucleotide binding]
452863002567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
452863002568	Histidine kinase; Region: HisKA_3; pfam07730
452863002569	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
452863002570	Domain of unknown function (DUF336); Region: DUF336; cl01249
452863002571	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
452863002572	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
452863002573	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
452863002574	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
452863002575	active site
452863002576	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
452863002577	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
452863002578	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
452863002579	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863002580	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863002581	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863002582	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
452863002583	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
452863002584	homodimer interface [polypeptide binding]; other site
452863002585	NAD binding pocket [chemical binding]; other site
452863002586	ATP binding pocket [chemical binding]; other site
452863002587	Mg binding site [ion binding]; other site
452863002588	active-site loop [active]
452863002589	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863002590	active site
452863002591	GAF domain; Region: GAF; cl17456
452863002592	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863002593	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863002594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863002595	UMP phosphatase; Provisional; Region: PRK10444
452863002596	active site
452863002597	motif I; other site
452863002598	motif II; other site
452863002599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863002600	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
452863002601	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
452863002602	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
452863002603	active site
452863002604	intersubunit interface [polypeptide binding]; other site
452863002605	zinc binding site [ion binding]; other site
452863002606	Na+ binding site [ion binding]; other site
452863002607	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
452863002608	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
452863002609	putative uracil binding site [chemical binding]; other site
452863002610	putative active site [active]
452863002611	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
452863002612	Catalytic site [active]
452863002613	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
452863002614	active site
452863002615	Zn binding site [ion binding]; other site
452863002616	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
452863002617	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
452863002618	GDP-binding site [chemical binding]; other site
452863002619	ACT binding site; other site
452863002620	IMP binding site; other site
452863002621	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
452863002622	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
452863002623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863002624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863002625	DNA binding residues [nucleotide binding]
452863002626	CoA binding domain; Region: CoA_binding; cl17356
452863002627	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
452863002628	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
452863002629	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
452863002630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
452863002631	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
452863002632	Uncharacterized conserved protein [Function unknown]; Region: COG1359
452863002633	Protein of unknown function (DUF503); Region: DUF503; pfam04456
452863002634	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863002635	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
452863002636	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
452863002637	dimerization interface [polypeptide binding]; other site
452863002638	ATP binding site [chemical binding]; other site
452863002639	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
452863002640	dimerization interface [polypeptide binding]; other site
452863002641	ATP binding site [chemical binding]; other site
452863002642	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
452863002643	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
452863002644	putative active site [active]
452863002645	catalytic triad [active]
452863002646	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
452863002647	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
452863002648	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
452863002649	active site
452863002650	catalytic triad [active]
452863002651	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
452863002652	PA/protease or protease-like domain interface [polypeptide binding]; other site
452863002653	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
452863002654	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
452863002655	catalytic residues [active]
452863002656	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
452863002657	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863002658	MarR family; Region: MarR; pfam01047
452863002659	aspartate kinase; Reviewed; Region: PRK06635
452863002660	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
452863002661	putative nucleotide binding site [chemical binding]; other site
452863002662	putative catalytic residues [active]
452863002663	putative Mg ion binding site [ion binding]; other site
452863002664	putative aspartate binding site [chemical binding]; other site
452863002665	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
452863002666	putative allosteric regulatory site; other site
452863002667	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
452863002668	putative allosteric regulatory residue; other site
452863002669	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
452863002670	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863002671	Walker A/P-loop; other site
452863002672	ATP binding site [chemical binding]; other site
452863002673	Q-loop/lid; other site
452863002674	ABC transporter signature motif; other site
452863002675	Walker B; other site
452863002676	D-loop; other site
452863002677	H-loop/switch region; other site
452863002678	recombination protein RecR; Reviewed; Region: recR; PRK00076
452863002679	RecR protein; Region: RecR; pfam02132
452863002680	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
452863002681	putative active site [active]
452863002682	putative metal-binding site [ion binding]; other site
452863002683	tetramer interface [polypeptide binding]; other site
452863002684	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
452863002685	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863002686	Walker A motif; other site
452863002687	ATP binding site [chemical binding]; other site
452863002688	Walker B motif; other site
452863002689	arginine finger; other site
452863002690	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
452863002691	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
452863002692	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863002693	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863002694	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
452863002695	catalytic residues [active]
452863002696	dimer interface [polypeptide binding]; other site
452863002697	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
452863002698	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
452863002699	active site
452863002700	metal binding site [ion binding]; metal-binding site
452863002701	hexamer interface [polypeptide binding]; other site
452863002702	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
452863002703	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
452863002704	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
452863002705	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
452863002706	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863002707	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002708	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
452863002709	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
452863002710	catalytic residues [active]
452863002711	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863002712	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
452863002713	putative ADP-binding pocket [chemical binding]; other site
452863002714	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
452863002715	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
452863002716	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863002717	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
452863002718	dimerization interface [polypeptide binding]; other site
452863002719	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
452863002720	NAD binding site [chemical binding]; other site
452863002721	ligand binding site [chemical binding]; other site
452863002722	catalytic site [active]
452863002723	cyanate transporter; Region: CynX; TIGR00896
452863002724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002725	putative substrate translocation pore; other site
452863002726	malate synthase A; Region: malate_syn_A; TIGR01344
452863002727	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
452863002728	active site
452863002729	isocitrate lyase; Provisional; Region: PRK15063
452863002730	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
452863002731	tetramer interface [polypeptide binding]; other site
452863002732	active site
452863002733	Mg2+/Mn2+ binding site [ion binding]; other site
452863002734	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863002735	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863002736	non-specific DNA binding site [nucleotide binding]; other site
452863002737	salt bridge; other site
452863002738	sequence-specific DNA binding site [nucleotide binding]; other site
452863002739	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
452863002740	Domain of unknown function (DUF955); Region: DUF955; pfam06114
452863002741	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
452863002742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863002743	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
452863002744	dimerization interface [polypeptide binding]; other site
452863002745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863002746	dimer interface [polypeptide binding]; other site
452863002747	phosphorylation site [posttranslational modification]
452863002748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863002749	ATP binding site [chemical binding]; other site
452863002750	Mg2+ binding site [ion binding]; other site
452863002751	G-X-G motif; other site
452863002752	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863002753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863002754	active site
452863002755	phosphorylation site [posttranslational modification]
452863002756	intermolecular recognition site; other site
452863002757	dimerization interface [polypeptide binding]; other site
452863002758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863002759	DNA binding site [nucleotide binding]
452863002760	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
452863002761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002762	putative substrate translocation pore; other site
452863002763	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002764	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
452863002765	pyruvate dehydrogenase; Provisional; Region: PRK06546
452863002766	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
452863002767	PYR/PP interface [polypeptide binding]; other site
452863002768	dimer interface [polypeptide binding]; other site
452863002769	tetramer interface [polypeptide binding]; other site
452863002770	TPP binding site [chemical binding]; other site
452863002771	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863002772	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
452863002773	TPP-binding site [chemical binding]; other site
452863002774	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
452863002775	dimer interface [polypeptide binding]; other site
452863002776	substrate binding site [chemical binding]; other site
452863002777	ATP binding site [chemical binding]; other site
452863002778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863002779	TIGR01777 family protein; Region: yfcH
452863002780	NAD(P) binding site [chemical binding]; other site
452863002781	active site
452863002782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863002783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002784	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
452863002785	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863002786	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863002787	putative active site [active]
452863002788	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
452863002789	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
452863002790	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
452863002791	putative hydrophobic ligand binding site [chemical binding]; other site
452863002792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
452863002793	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
452863002794	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
452863002795	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
452863002796	substrate binding [chemical binding]; other site
452863002797	active site
452863002798	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
452863002799	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
452863002800	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
452863002801	Walker A/P-loop; other site
452863002802	ATP binding site [chemical binding]; other site
452863002803	Q-loop/lid; other site
452863002804	ABC transporter signature motif; other site
452863002805	Walker B; other site
452863002806	D-loop; other site
452863002807	H-loop/switch region; other site
452863002808	TOBE domain; Region: TOBE_2; pfam08402
452863002809	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
452863002810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002811	putative PBP binding loops; other site
452863002812	ABC-ATPase subunit interface; other site
452863002813	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002814	dimer interface [polypeptide binding]; other site
452863002815	conserved gate region; other site
452863002816	putative PBP binding loops; other site
452863002817	ABC-ATPase subunit interface; other site
452863002818	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863002819	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
452863002820	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
452863002821	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
452863002822	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
452863002823	NAD binding site [chemical binding]; other site
452863002824	homodimer interface [polypeptide binding]; other site
452863002825	homotetramer interface [polypeptide binding]; other site
452863002826	active site
452863002827	acyl-coenzyme A oxidase; Region: PLN02526
452863002828	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863002829	active site
452863002830	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
452863002831	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
452863002832	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
452863002833	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
452863002834	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
452863002835	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863002836	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
452863002837	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
452863002838	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
452863002839	probable active site [active]
452863002840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863002841	putative DNA binding site [nucleotide binding]; other site
452863002842	putative Zn2+ binding site [ion binding]; other site
452863002843	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
452863002844	hydrophobic ligand binding site; other site
452863002845	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
452863002846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863002847	DNA-binding site [nucleotide binding]; DNA binding site
452863002848	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863002849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863002850	homodimer interface [polypeptide binding]; other site
452863002851	catalytic residue [active]
452863002852	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
452863002853	Predicted membrane protein [Function unknown]; Region: COG2364
452863002854	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
452863002855	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
452863002856	putative DNA binding site [nucleotide binding]; other site
452863002857	catalytic residue [active]
452863002858	putative H2TH interface [polypeptide binding]; other site
452863002859	putative catalytic residues [active]
452863002860	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
452863002861	ATP-dependent helicase; Provisional; Region: PRK13767
452863002862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863002863	ATP binding site [chemical binding]; other site
452863002864	putative Mg++ binding site [ion binding]; other site
452863002865	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863002866	nucleotide binding region [chemical binding]; other site
452863002867	ATP-binding site [chemical binding]; other site
452863002868	DEAD/H associated; Region: DEAD_assoc; pfam08494
452863002869	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
452863002870	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
452863002871	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
452863002872	Nitronate monooxygenase; Region: NMO; pfam03060
452863002873	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
452863002874	FMN binding site [chemical binding]; other site
452863002875	substrate binding site [chemical binding]; other site
452863002876	putative catalytic residue [active]
452863002877	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
452863002878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002879	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
452863002880	classical (c) SDRs; Region: SDR_c; cd05233
452863002881	NAD(P) binding site [chemical binding]; other site
452863002882	active site
452863002883	salicylate hydroxylase; Provisional; Region: PRK08163
452863002884	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863002885	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
452863002886	active site
452863002887	substrate binding site [chemical binding]; other site
452863002888	ATP binding site [chemical binding]; other site
452863002889	Phosphotransferase enzyme family; Region: APH; pfam01636
452863002890	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863002891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
452863002892	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863002893	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
452863002894	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
452863002895	Cytochrome P450; Region: p450; cl12078
452863002896	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863002897	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735
452863002898	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863002899	active site
452863002900	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863002901	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
452863002902	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
452863002903	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
452863002904	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863002905	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
452863002906	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863002907	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
452863002908	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863002909	putative Zn2+ binding site [ion binding]; other site
452863002910	putative DNA binding site [nucleotide binding]; other site
452863002911	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863002912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863002913	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863002914	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863002915	DNA binding site [nucleotide binding]
452863002916	domain linker motif; other site
452863002917	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863002918	ligand binding site [chemical binding]; other site
452863002919	dimerization interface [polypeptide binding]; other site
452863002920	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863002921	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863002922	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863002923	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863002924	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
452863002925	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863002926	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863002927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002928	dimer interface [polypeptide binding]; other site
452863002929	conserved gate region; other site
452863002930	putative PBP binding loops; other site
452863002931	ABC-ATPase subunit interface; other site
452863002932	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863002933	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
452863002934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863002935	dimer interface [polypeptide binding]; other site
452863002936	conserved gate region; other site
452863002937	putative PBP binding loops; other site
452863002938	ABC-ATPase subunit interface; other site
452863002939	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863002940	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
452863002941	Walker A/P-loop; other site
452863002942	ATP binding site [chemical binding]; other site
452863002943	Q-loop/lid; other site
452863002944	ABC transporter signature motif; other site
452863002945	Walker B; other site
452863002946	D-loop; other site
452863002947	H-loop/switch region; other site
452863002948	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863002949	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
452863002950	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863002951	Walker A/P-loop; other site
452863002952	ATP binding site [chemical binding]; other site
452863002953	Q-loop/lid; other site
452863002954	ABC transporter signature motif; other site
452863002955	Walker B; other site
452863002956	D-loop; other site
452863002957	H-loop/switch region; other site
452863002958	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863002959	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863002960	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863002961	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863002962	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863002963	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863002964	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863002965	DNA binding site [nucleotide binding]
452863002966	domain linker motif; other site
452863002967	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863002968	dimerization interface [polypeptide binding]; other site
452863002969	ligand binding site [chemical binding]; other site
452863002970	glucuronate isomerase; Reviewed; Region: PRK02925
452863002971	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
452863002972	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
452863002973	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
452863002974	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
452863002975	glucuronide transporter; Provisional; Region: PRK09848
452863002976	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
452863002977	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
452863002978	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
452863002979	metal binding site [ion binding]; metal-binding site
452863002980	substrate binding pocket [chemical binding]; other site
452863002981	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
452863002982	AAA domain; Region: AAA_33; pfam13671
452863002983	ATP-binding site [chemical binding]; other site
452863002984	Gluconate-6-phosphate binding site [chemical binding]; other site
452863002985	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
452863002986	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
452863002987	RHS Repeat; Region: RHS_repeat; pfam05593
452863002988	RHS Repeat; Region: RHS_repeat; cl11982
452863002989	RHS Repeat; Region: RHS_repeat; cl11982
452863002990	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
452863002991	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863002992	active site
452863002993	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
452863002994	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
452863002995	putative NAD(P) binding site [chemical binding]; other site
452863002996	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
452863002997	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
452863002998	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863002999	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
452863003000	nucleoside/Zn binding site; other site
452863003001	dimer interface [polypeptide binding]; other site
452863003002	catalytic motif [active]
452863003003	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
452863003004	active site
452863003005	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
452863003006	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863003007	active site
452863003008	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
452863003009	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863003010	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
452863003011	N-acetyl-D-glucosamine binding site [chemical binding]; other site
452863003012	catalytic residue [active]
452863003013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863003014	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
452863003015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863003016	dimer interface [polypeptide binding]; other site
452863003017	phosphorylation site [posttranslational modification]
452863003018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863003019	ATP binding site [chemical binding]; other site
452863003020	Mg2+ binding site [ion binding]; other site
452863003021	G-X-G motif; other site
452863003022	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863003023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863003024	active site
452863003025	phosphorylation site [posttranslational modification]
452863003026	intermolecular recognition site; other site
452863003027	dimerization interface [polypeptide binding]; other site
452863003028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863003029	DNA binding site [nucleotide binding]
452863003030	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863003031	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863003032	DNA binding site [nucleotide binding]
452863003033	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863003034	catalytic core [active]
452863003035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863003036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863003037	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
452863003038	putative dimerization interface [polypeptide binding]; other site
452863003039	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
452863003040	EamA-like transporter family; Region: EamA; pfam00892
452863003041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863003042	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863003043	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
452863003044	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
452863003045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863003046	Walker A/P-loop; other site
452863003047	ATP binding site [chemical binding]; other site
452863003048	Q-loop/lid; other site
452863003049	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
452863003050	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863003051	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863003052	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
452863003053	active site
452863003054	substrate-binding site [chemical binding]; other site
452863003055	metal-binding site [ion binding]
452863003056	GTP binding site [chemical binding]; other site
452863003057	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
452863003058	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
452863003059	heme-binding site [chemical binding]; other site
452863003060	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
452863003061	FAD binding pocket [chemical binding]; other site
452863003062	FAD binding motif [chemical binding]; other site
452863003063	phosphate binding motif [ion binding]; other site
452863003064	beta-alpha-beta structure motif; other site
452863003065	NAD binding pocket [chemical binding]; other site
452863003066	Heme binding  pocket [chemical binding]; other site
452863003067	Predicted transcriptional regulator [Transcription]; Region: COG1959
452863003068	Transcriptional regulator; Region: Rrf2; pfam02082
452863003069	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
452863003070	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
452863003071	active site
452863003072	substrate binding site [chemical binding]; other site
452863003073	metal binding site [ion binding]; metal-binding site
452863003074	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
452863003075	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863003076	ATP binding site [chemical binding]; other site
452863003077	putative Mg++ binding site [ion binding]; other site
452863003078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863003079	nucleotide binding region [chemical binding]; other site
452863003080	ATP-binding site [chemical binding]; other site
452863003081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003082	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863003083	putative substrate translocation pore; other site
452863003084	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
452863003085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863003086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863003087	Coenzyme A binding pocket [chemical binding]; other site
452863003088	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
452863003089	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863003090	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
452863003091	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
452863003092	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
452863003093	active site
452863003094	iron coordination sites [ion binding]; other site
452863003095	substrate binding pocket [chemical binding]; other site
452863003096	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
452863003097	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
452863003098	generic binding surface I; other site
452863003099	generic binding surface II; other site
452863003100	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
452863003101	putative active site [active]
452863003102	putative catalytic site [active]
452863003103	putative Mg binding site IVb [ion binding]; other site
452863003104	putative phosphate binding site [ion binding]; other site
452863003105	putative DNA binding site [nucleotide binding]; other site
452863003106	putative Mg binding site IVa [ion binding]; other site
452863003107	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
452863003108	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
452863003109	putative active site [active]
452863003110	putative metal binding site [ion binding]; other site
452863003111	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
452863003112	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863003113	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863003114	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863003115	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863003116	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
452863003117	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
452863003118	NAD(P) binding site [chemical binding]; other site
452863003119	Predicted transcriptional regulators [Transcription]; Region: COG1695
452863003120	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
452863003121	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863003122	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
452863003123	Walker A/P-loop; other site
452863003124	ATP binding site [chemical binding]; other site
452863003125	Q-loop/lid; other site
452863003126	ABC transporter signature motif; other site
452863003127	Walker B; other site
452863003128	D-loop; other site
452863003129	H-loop/switch region; other site
452863003130	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
452863003131	carbon starvation protein A; Provisional; Region: PRK15015
452863003132	Carbon starvation protein CstA; Region: CstA; pfam02554
452863003133	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
452863003134	Protein of unknown function (DUF466); Region: DUF466; pfam04328
452863003135	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
452863003136	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863003137	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863003138	active site
452863003139	catalytic tetrad [active]
452863003140	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
452863003141	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863003142	TAP-like protein; Region: Abhydrolase_4; pfam08386
452863003143	DNA polymerase III subunit delta'; Validated; Region: PRK07940
452863003144	DNA polymerase III subunit delta'; Validated; Region: PRK08485
452863003145	thymidylate kinase; Validated; Region: tmk; PRK00698
452863003146	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
452863003147	TMP-binding site; other site
452863003148	ATP-binding site [chemical binding]; other site
452863003149	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
452863003150	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863003151	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863003152	catalytic residue [active]
452863003153	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
452863003154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863003155	catalytic core [active]
452863003156	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
452863003157	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
452863003158	PhoU domain; Region: PhoU; pfam01895
452863003159	PhoU domain; Region: PhoU; pfam01895
452863003160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863003161	dimer interface [polypeptide binding]; other site
452863003162	phosphorylation site [posttranslational modification]
452863003163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863003164	ATP binding site [chemical binding]; other site
452863003165	Mg2+ binding site [ion binding]; other site
452863003166	G-X-G motif; other site
452863003167	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863003168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863003169	active site
452863003170	phosphorylation site [posttranslational modification]
452863003171	intermolecular recognition site; other site
452863003172	dimerization interface [polypeptide binding]; other site
452863003173	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863003174	DNA binding site [nucleotide binding]
452863003175	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
452863003176	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
452863003177	substrate binding site; other site
452863003178	dimer interface; other site
452863003179	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
452863003180	homotrimer interaction site [polypeptide binding]; other site
452863003181	zinc binding site [ion binding]; other site
452863003182	CDP-binding sites; other site
452863003183	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
452863003184	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863003185	active site
452863003186	HIGH motif; other site
452863003187	nucleotide binding site [chemical binding]; other site
452863003188	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
452863003189	KMSKS motif; other site
452863003190	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
452863003191	tRNA binding surface [nucleotide binding]; other site
452863003192	anticodon binding site; other site
452863003193	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
452863003194	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
452863003195	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
452863003196	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
452863003197	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
452863003198	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
452863003199	active site
452863003200	catalytic site [active]
452863003201	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
452863003202	active site
452863003203	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
452863003204	putative RNAase interaction site [polypeptide binding]; other site
452863003205	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
452863003206	putative homodimer interface [polypeptide binding]; other site
452863003207	putative active site pocket [active]
452863003208	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
452863003209	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
452863003210	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
452863003211	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
452863003212	active site
452863003213	homodimer interface [polypeptide binding]; other site
452863003214	catalytic site [active]
452863003215	acceptor binding site [chemical binding]; other site
452863003216	trehalose synthase; Region: treS_nterm; TIGR02456
452863003217	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
452863003218	active site
452863003219	catalytic site [active]
452863003220	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
452863003221	glycogen branching enzyme; Provisional; Region: PRK14705
452863003222	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
452863003223	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
452863003224	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
452863003225	active site
452863003226	catalytic site [active]
452863003227	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
452863003228	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
452863003229	hydrophobic ligand binding site; other site
452863003230	FAD binding domain; Region: FAD_binding_4; pfam01565
452863003231	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
452863003232	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
452863003233	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
452863003234	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
452863003235	Walker A/P-loop; other site
452863003236	ATP binding site [chemical binding]; other site
452863003237	Q-loop/lid; other site
452863003238	ABC transporter signature motif; other site
452863003239	Walker B; other site
452863003240	D-loop; other site
452863003241	H-loop/switch region; other site
452863003242	TOBE domain; Region: TOBE; pfam03459
452863003243	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
452863003244	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
452863003245	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
452863003246	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
452863003247	active site
452863003248	homotetramer interface [polypeptide binding]; other site
452863003249	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
452863003250	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
452863003251	catalytic residues [active]
452863003252	ChaB; Region: ChaB; pfam06150
452863003253	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
452863003254	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
452863003255	elongation factor G; Reviewed; Region: PRK12740
452863003256	G1 box; other site
452863003257	putative GEF interaction site [polypeptide binding]; other site
452863003258	GTP/Mg2+ binding site [chemical binding]; other site
452863003259	Switch I region; other site
452863003260	G2 box; other site
452863003261	G3 box; other site
452863003262	Switch II region; other site
452863003263	G4 box; other site
452863003264	G5 box; other site
452863003265	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
452863003266	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
452863003267	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
452863003268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003269	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863003270	putative substrate translocation pore; other site
452863003271	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863003272	Amino acid permease; Region: AA_permease_2; pfam13520
452863003273	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
452863003274	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
452863003275	dimerization interface [polypeptide binding]; other site
452863003276	DPS ferroxidase diiron center [ion binding]; other site
452863003277	ion pore; other site
452863003278	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
452863003279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003280	putative substrate translocation pore; other site
452863003281	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863003282	glycine dehydrogenase; Provisional; Region: PRK05367
452863003283	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
452863003284	tetramer interface [polypeptide binding]; other site
452863003285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863003286	catalytic residue [active]
452863003287	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
452863003288	tetramer interface [polypeptide binding]; other site
452863003289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863003290	catalytic residue [active]
452863003291	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
452863003292	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863003293	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
452863003294	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
452863003295	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
452863003296	TspO/MBR family; Region: TspO_MBR; pfam03073
452863003297	FemAB family; Region: FemAB; pfam02388
452863003298	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
452863003299	FemAB family; Region: FemAB; pfam02388
452863003300	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
452863003301	Uncharacterized conserved protein [Function unknown]; Region: COG2966
452863003302	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
452863003303	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
452863003304	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
452863003305	FAD binding pocket [chemical binding]; other site
452863003306	FAD binding motif [chemical binding]; other site
452863003307	phosphate binding motif [ion binding]; other site
452863003308	NAD binding pocket [chemical binding]; other site
452863003309	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
452863003310	ligand binding site [chemical binding]; other site
452863003311	active site
452863003312	UGI interface [polypeptide binding]; other site
452863003313	catalytic site [active]
452863003314	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
452863003315	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
452863003316	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863003317	DNA-binding site [nucleotide binding]; DNA binding site
452863003318	RNA-binding motif; other site
452863003319	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
452863003320	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
452863003321	ligand binding site [chemical binding]; other site
452863003322	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863003323	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
452863003324	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
452863003325	ring oligomerisation interface [polypeptide binding]; other site
452863003326	ATP/Mg binding site [chemical binding]; other site
452863003327	stacking interactions; other site
452863003328	hinge regions; other site
452863003329	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863003330	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863003331	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
452863003332	RNA/DNA hybrid binding site [nucleotide binding]; other site
452863003333	active site
452863003334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
452863003335	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
452863003336	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863003337	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
452863003338	dimerization interface [polypeptide binding]; other site
452863003339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863003340	dimer interface [polypeptide binding]; other site
452863003341	phosphorylation site [posttranslational modification]
452863003342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863003343	ATP binding site [chemical binding]; other site
452863003344	Mg2+ binding site [ion binding]; other site
452863003345	G-X-G motif; other site
452863003346	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863003347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863003348	active site
452863003349	phosphorylation site [posttranslational modification]
452863003350	intermolecular recognition site; other site
452863003351	dimerization interface [polypeptide binding]; other site
452863003352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863003353	DNA binding site [nucleotide binding]
452863003354	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
452863003355	NodB motif; other site
452863003356	active site
452863003357	catalytic site [active]
452863003358	metal binding site [ion binding]; metal-binding site
452863003359	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
452863003360	Domain of unknown function (DUF427); Region: DUF427; pfam04248
452863003361	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
452863003362	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
452863003363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
452863003364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863003365	ATP binding site [chemical binding]; other site
452863003366	putative Mg++ binding site [ion binding]; other site
452863003367	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863003368	nucleotide binding region [chemical binding]; other site
452863003369	ATP-binding site [chemical binding]; other site
452863003370	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
452863003371	WYL domain; Region: WYL; pfam13280
452863003372	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863003373	DNA-binding site [nucleotide binding]; DNA binding site
452863003374	RNA-binding motif; other site
452863003375	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
452863003376	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863003377	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863003378	catalytic residue [active]
452863003379	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
452863003380	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
452863003381	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
452863003382	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
452863003383	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863003384	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863003385	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
452863003386	NlpC/P60 family; Region: NLPC_P60; pfam00877
452863003387	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
452863003388	NlpC/P60 family; Region: NLPC_P60; cl17555
452863003389	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
452863003390	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863003391	active site
452863003392	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
452863003393	GTP binding site; other site
452863003394	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
452863003395	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
452863003396	dimer interface [polypeptide binding]; other site
452863003397	putative functional site; other site
452863003398	putative MPT binding site; other site
452863003399	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
452863003400	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
452863003401	active site
452863003402	catalytic site [active]
452863003403	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
452863003404	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
452863003405	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
452863003406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863003407	Walker A/P-loop; other site
452863003408	ATP binding site [chemical binding]; other site
452863003409	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863003410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863003411	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863003412	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863003413	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863003414	Walker A/P-loop; other site
452863003415	ATP binding site [chemical binding]; other site
452863003416	Q-loop/lid; other site
452863003417	ABC transporter signature motif; other site
452863003418	Walker B; other site
452863003419	D-loop; other site
452863003420	H-loop/switch region; other site
452863003421	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
452863003422	nudix motif; other site
452863003423	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
452863003424	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
452863003425	active site
452863003426	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
452863003427	Part of AAA domain; Region: AAA_19; pfam13245
452863003428	Family description; Region: UvrD_C_2; pfam13538
452863003429	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
452863003430	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
452863003431	CoA-ligase; Region: Ligase_CoA; pfam00549
452863003432	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
452863003433	CoA binding domain; Region: CoA_binding; smart00881
452863003434	CoA-ligase; Region: Ligase_CoA; pfam00549
452863003435	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
452863003436	putative hydrophobic ligand binding site [chemical binding]; other site
452863003437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863003438	dimerization interface [polypeptide binding]; other site
452863003439	putative DNA binding site [nucleotide binding]; other site
452863003440	putative Zn2+ binding site [ion binding]; other site
452863003441	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
452863003442	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
452863003443	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863003444	substrate binding site [chemical binding]; other site
452863003445	ATP binding site [chemical binding]; other site
452863003446	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
452863003447	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863003448	PYR/PP interface [polypeptide binding]; other site
452863003449	dimer interface [polypeptide binding]; other site
452863003450	TPP binding site [chemical binding]; other site
452863003451	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863003452	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
452863003453	TPP-binding site; other site
452863003454	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
452863003455	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
452863003456	tetrameric interface [polypeptide binding]; other site
452863003457	NAD binding site [chemical binding]; other site
452863003458	catalytic residues [active]
452863003459	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863003460	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863003461	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863003462	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863003463	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863003464	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
452863003465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003466	putative substrate translocation pore; other site
452863003467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003468	MarR family; Region: MarR_2; pfam12802
452863003469	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863003470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003471	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863003472	putative substrate translocation pore; other site
452863003473	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
452863003474	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
452863003475	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
452863003476	multiple promoter invertase; Provisional; Region: mpi; PRK13413
452863003477	catalytic residues [active]
452863003478	catalytic nucleophile [active]
452863003479	Presynaptic Site I dimer interface [polypeptide binding]; other site
452863003480	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
452863003481	Synaptic Flat tetramer interface [polypeptide binding]; other site
452863003482	Synaptic Site I dimer interface [polypeptide binding]; other site
452863003483	DNA binding site [nucleotide binding]
452863003484	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
452863003485	DNA-binding interface [nucleotide binding]; DNA binding site
452863003486	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863003487	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863003488	DNA binding site [nucleotide binding]
452863003489	domain linker motif; other site
452863003490	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863003491	dimerization interface [polypeptide binding]; other site
452863003492	ligand binding site [chemical binding]; other site
452863003493	KduI/IolB family; Region: KduI; pfam04962
452863003494	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
452863003495	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003496	DNA-binding site [nucleotide binding]; DNA binding site
452863003497	UTRA domain; Region: UTRA; pfam07702
452863003498	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
452863003499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003500	putative substrate translocation pore; other site
452863003501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003502	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
452863003503	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
452863003504	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
452863003505	diiron binding motif [ion binding]; other site
452863003506	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
452863003507	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
452863003508	Na binding site [ion binding]; other site
452863003509	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
452863003510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863003511	non-specific DNA binding site [nucleotide binding]; other site
452863003512	salt bridge; other site
452863003513	sequence-specific DNA binding site [nucleotide binding]; other site
452863003514	Cupin domain; Region: Cupin_2; pfam07883
452863003515	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863003516	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863003517	putative active site [active]
452863003518	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
452863003519	agmatinase; Region: agmatinase; TIGR01230
452863003520	oligomer interface [polypeptide binding]; other site
452863003521	putative active site [active]
452863003522	Mn binding site [ion binding]; other site
452863003523	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
452863003524	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863003525	PYR/PP interface [polypeptide binding]; other site
452863003526	dimer interface [polypeptide binding]; other site
452863003527	TPP binding site [chemical binding]; other site
452863003528	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863003529	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
452863003530	TPP-binding site [chemical binding]; other site
452863003531	Transcriptional regulators [Transcription]; Region: MarR; COG1846
452863003532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863003533	dimerization interface [polypeptide binding]; other site
452863003534	putative Zn2+ binding site [ion binding]; other site
452863003535	putative DNA binding site [nucleotide binding]; other site
452863003536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863003537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003538	putative substrate translocation pore; other site
452863003539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003540	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863003541	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863003542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863003543	Walker A/P-loop; other site
452863003544	ATP binding site [chemical binding]; other site
452863003545	Q-loop/lid; other site
452863003546	ABC transporter signature motif; other site
452863003547	Walker B; other site
452863003548	D-loop; other site
452863003549	H-loop/switch region; other site
452863003550	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863003551	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863003552	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
452863003553	Walker A/P-loop; other site
452863003554	ATP binding site [chemical binding]; other site
452863003555	Q-loop/lid; other site
452863003556	ABC transporter signature motif; other site
452863003557	Walker B; other site
452863003558	D-loop; other site
452863003559	H-loop/switch region; other site
452863003560	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
452863003561	active site
452863003562	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
452863003563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863003564	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
452863003565	Walker A motif; other site
452863003566	ATP binding site [chemical binding]; other site
452863003567	Walker B motif; other site
452863003568	arginine finger; other site
452863003569	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
452863003570	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
452863003571	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863003572	dimer interface [polypeptide binding]; other site
452863003573	phosphorylation site [posttranslational modification]
452863003574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863003575	ATP binding site [chemical binding]; other site
452863003576	Mg2+ binding site [ion binding]; other site
452863003577	G-X-G motif; other site
452863003578	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863003579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863003580	active site
452863003581	phosphorylation site [posttranslational modification]
452863003582	intermolecular recognition site; other site
452863003583	dimerization interface [polypeptide binding]; other site
452863003584	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863003585	DNA binding site [nucleotide binding]
452863003586	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
452863003587	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
452863003588	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
452863003589	additional DNA contacts [nucleotide binding]; other site
452863003590	mismatch recognition site; other site
452863003591	active site
452863003592	zinc binding site [ion binding]; other site
452863003593	DNA intercalation site [nucleotide binding]; other site
452863003594	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863003595	biotin synthase; Validated; Region: PRK06256
452863003596	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863003597	FeS/SAM binding site; other site
452863003598	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
452863003599	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
452863003600	Na binding site [ion binding]; other site
452863003601	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
452863003602	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
452863003603	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
452863003604	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
452863003605	FMN binding site [chemical binding]; other site
452863003606	active site
452863003607	substrate binding site [chemical binding]; other site
452863003608	catalytic residue [active]
452863003609	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
452863003610	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
452863003611	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
452863003612	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
452863003613	RNA binding site [nucleotide binding]; other site
452863003614	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863003615	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
452863003616	putative NAD(P) binding site [chemical binding]; other site
452863003617	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
452863003618	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863003619	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
452863003620	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
452863003621	active site
452863003622	purine riboside binding site [chemical binding]; other site
452863003623	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
452863003624	acylphosphatase; Provisional; Region: PRK14427
452863003625	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
452863003626	RNase_H superfamily; Region: RNase_H_2; pfam13482
452863003627	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
452863003628	Part of AAA domain; Region: AAA_19; pfam13245
452863003629	AAA domain; Region: AAA_12; pfam13087
452863003630	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863003631	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003632	DNA-binding site [nucleotide binding]; DNA binding site
452863003633	FCD domain; Region: FCD; pfam07729
452863003634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003635	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863003636	putative substrate translocation pore; other site
452863003637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
452863003638	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
452863003639	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
452863003640	putative NAD(P) binding site [chemical binding]; other site
452863003641	catalytic Zn binding site [ion binding]; other site
452863003642	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
452863003643	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
452863003644	putative active site pocket [active]
452863003645	putative metal binding site [ion binding]; other site
452863003646	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
452863003647	substrate binding site [chemical binding]; other site
452863003648	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863003649	ATP binding site [chemical binding]; other site
452863003650	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
452863003651	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
452863003652	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
452863003653	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
452863003654	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
452863003655	active site
452863003656	intersubunit interface [polypeptide binding]; other site
452863003657	catalytic residue [active]
452863003658	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
452863003659	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
452863003660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863003661	ATP binding site [chemical binding]; other site
452863003662	putative Mg++ binding site [ion binding]; other site
452863003663	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863003664	nucleotide binding region [chemical binding]; other site
452863003665	ATP-binding site [chemical binding]; other site
452863003666	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
452863003667	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
452863003668	putative molybdopterin cofactor binding site [chemical binding]; other site
452863003669	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
452863003670	putative molybdopterin cofactor binding site; other site
452863003671	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863003672	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863003673	active site
452863003674	catalytic tetrad [active]
452863003675	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
452863003676	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
452863003677	NAD binding site [chemical binding]; other site
452863003678	catalytic Zn binding site [ion binding]; other site
452863003679	structural Zn binding site [ion binding]; other site
452863003680	Predicted acetyltransferase [General function prediction only]; Region: COG2388
452863003681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003682	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863003683	putative substrate translocation pore; other site
452863003684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003685	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
452863003686	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
452863003687	intersubunit interface [polypeptide binding]; other site
452863003688	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
452863003689	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
452863003690	active site
452863003691	catalytic site [active]
452863003692	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
452863003693	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
452863003694	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863003695	dimerization interface [polypeptide binding]; other site
452863003696	putative DNA binding site [nucleotide binding]; other site
452863003697	putative Zn2+ binding site [ion binding]; other site
452863003698	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
452863003699	putative hydrophobic ligand binding site [chemical binding]; other site
452863003700	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
452863003701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863003702	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863003703	DNA binding residues [nucleotide binding]
452863003704	dimerization interface [polypeptide binding]; other site
452863003705	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
452863003706	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
452863003707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003708	putative substrate translocation pore; other site
452863003709	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
452863003710	putative hydrophobic ligand binding site [chemical binding]; other site
452863003711	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
452863003712	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863003713	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
452863003714	Metal-binding active site; metal-binding site
452863003715	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863003716	active site
452863003717	Protein of unknown function (DUF664); Region: DUF664; pfam04978
452863003718	DinB superfamily; Region: DinB_2; pfam12867
452863003719	H+ Antiporter protein; Region: 2A0121; TIGR00900
452863003720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003721	putative substrate translocation pore; other site
452863003722	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863003723	MarR family; Region: MarR; pfam01047
452863003724	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
452863003725	SOUL heme-binding protein; Region: SOUL; pfam04832
452863003726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863003727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863003728	non-specific DNA binding site [nucleotide binding]; other site
452863003729	salt bridge; other site
452863003730	sequence-specific DNA binding site [nucleotide binding]; other site
452863003731	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863003732	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
452863003733	SnoaL-like domain; Region: SnoaL_2; pfam12680
452863003734	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
452863003735	DinB superfamily; Region: DinB_2; pfam12867
452863003736	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863003737	Ligand Binding Site [chemical binding]; other site
452863003738	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863003739	Ligand Binding Site [chemical binding]; other site
452863003740	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
452863003741	FAD binding domain; Region: FAD_binding_2; pfam00890
452863003742	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863003743	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
452863003744	Coenzyme A binding pocket [chemical binding]; other site
452863003745	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
452863003746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003747	putative substrate translocation pore; other site
452863003748	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
452863003749	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
452863003750	active site turn [active]
452863003751	phosphorylation site [posttranslational modification]
452863003752	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
452863003753	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
452863003754	HPr interaction site; other site
452863003755	glycerol kinase (GK) interaction site [polypeptide binding]; other site
452863003756	active site
452863003757	phosphorylation site [posttranslational modification]
452863003758	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
452863003759	beta-galactosidase; Region: BGL; TIGR03356
452863003760	CAT RNA binding domain; Region: CAT_RBD; smart01061
452863003761	transcriptional antiterminator BglG; Provisional; Region: PRK09772
452863003762	PRD domain; Region: PRD; pfam00874
452863003763	PRD domain; Region: PRD; pfam00874
452863003764	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
452863003765	regulatory protein interface [polypeptide binding]; other site
452863003766	active site
452863003767	regulatory phosphorylation site [posttranslational modification]; other site
452863003768	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863003769	catalytic core [active]
452863003770	FAD binding domain; Region: FAD_binding_4; pfam01565
452863003771	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
452863003772	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
452863003773	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
452863003774	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
452863003775	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
452863003776	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
452863003777	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
452863003778	cytosine deaminase; Provisional; Region: PRK05985
452863003779	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
452863003780	active site
452863003781	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
452863003782	Beta-lactamase; Region: Beta-lactamase; pfam00144
452863003783	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
452863003784	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
452863003785	proline/glycine betaine transporter; Provisional; Region: PRK10642
452863003786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863003787	putative substrate translocation pore; other site
452863003788	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
452863003789	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
452863003790	Sulfate transporter family; Region: Sulfate_transp; pfam00916
452863003791	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
452863003792	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
452863003793	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
452863003794	putative NAD(P) binding site [chemical binding]; other site
452863003795	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
452863003796	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
452863003797	Clostridial hydrophobic W; Region: ChW; cl02763
452863003798	Clostridial hydrophobic W; Region: ChW; pfam07538
452863003799	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
452863003800	Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728
452863003801	Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728
452863003802	Clostridial hydrophobic W; Region: ChW; pfam07538
452863003803	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
452863003804	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
452863003805	active site
452863003806	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863003807	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
452863003808	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
452863003809	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
452863003810	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
452863003811	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863003812	PYR/PP interface [polypeptide binding]; other site
452863003813	dimer interface [polypeptide binding]; other site
452863003814	TPP binding site [chemical binding]; other site
452863003815	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863003816	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
452863003817	TPP-binding site [chemical binding]; other site
452863003818	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
452863003819	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
452863003820	AsnC family; Region: AsnC_trans_reg; pfam01037
452863003821	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
452863003822	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863003823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863003824	homodimer interface [polypeptide binding]; other site
452863003825	catalytic residue [active]
452863003826	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
452863003827	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
452863003828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863003829	non-specific DNA binding site [nucleotide binding]; other site
452863003830	salt bridge; other site
452863003831	sequence-specific DNA binding site [nucleotide binding]; other site
452863003832	Domain of unknown function (DUF955); Region: DUF955; pfam06114
452863003833	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
452863003834	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863003835	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003836	DNA-binding site [nucleotide binding]; DNA binding site
452863003837	FCD domain; Region: FCD; pfam07729
452863003838	PLD-like domain; Region: PLDc_2; pfam13091
452863003839	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
452863003840	homodimer interface [polypeptide binding]; other site
452863003841	putative active site [active]
452863003842	catalytic site [active]
452863003843	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
452863003844	putative homodimer interface [polypeptide binding]; other site
452863003845	putative active site [active]
452863003846	catalytic site [active]
452863003847	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
452863003848	PLD-like domain; Region: PLDc_2; pfam13091
452863003849	putative homodimer interface [polypeptide binding]; other site
452863003850	putative active site [active]
452863003851	catalytic site [active]
452863003852	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
452863003853	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863003854	ATP binding site [chemical binding]; other site
452863003855	putative Mg++ binding site [ion binding]; other site
452863003856	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863003857	nucleotide binding region [chemical binding]; other site
452863003858	ATP-binding site [chemical binding]; other site
452863003859	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
452863003860	EBNA-3B; Provisional; Region: PHA03378
452863003861	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
452863003862	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
452863003863	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
452863003864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863003865	ATP binding site [chemical binding]; other site
452863003866	putative Mg++ binding site [ion binding]; other site
452863003867	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
452863003868	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
452863003869	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
452863003870	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
452863003871	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
452863003872	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
452863003873	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
452863003874	HsdM N-terminal domain; Region: HsdM_N; pfam12161
452863003875	Methyltransferase domain; Region: Methyltransf_26; pfam13659
452863003876	Homeobox associated leucine zipper; Region: HALZ; cl02577
452863003877	YciI-like protein; Reviewed; Region: PRK12866
452863003878	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
452863003879	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
452863003880	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
452863003881	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
452863003882	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
452863003883	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
452863003884	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863003885	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
452863003886	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863003887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863003888	dimer interface [polypeptide binding]; other site
452863003889	conserved gate region; other site
452863003890	putative PBP binding loops; other site
452863003891	ABC-ATPase subunit interface; other site
452863003892	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
452863003893	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
452863003894	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863003895	Walker A/P-loop; other site
452863003896	ATP binding site [chemical binding]; other site
452863003897	Q-loop/lid; other site
452863003898	ABC transporter signature motif; other site
452863003899	Walker B; other site
452863003900	D-loop; other site
452863003901	H-loop/switch region; other site
452863003902	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863003903	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
452863003904	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863003905	Walker A/P-loop; other site
452863003906	ATP binding site [chemical binding]; other site
452863003907	Q-loop/lid; other site
452863003908	ABC transporter signature motif; other site
452863003909	Walker B; other site
452863003910	D-loop; other site
452863003911	H-loop/switch region; other site
452863003912	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863003913	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863003914	active site
452863003915	catalytic tetrad [active]
452863003916	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
452863003917	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
452863003918	BNR repeat-like domain; Region: BNR_2; pfam13088
452863003919	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863003920	classical (c) SDRs; Region: SDR_c; cd05233
452863003921	NAD(P) binding site [chemical binding]; other site
452863003922	active site
452863003923	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
452863003924	Lipase (class 2); Region: Lipase_2; pfam01674
452863003925	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
452863003926	Hemerythrin-like domain; Region: Hr-like; cd12108
452863003927	Fe binding site [ion binding]; other site
452863003928	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
452863003929	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
452863003930	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863003931	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863003932	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
452863003933	Walker A/P-loop; other site
452863003934	ATP binding site [chemical binding]; other site
452863003935	Q-loop/lid; other site
452863003936	ABC transporter signature motif; other site
452863003937	Walker B; other site
452863003938	D-loop; other site
452863003939	H-loop/switch region; other site
452863003940	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
452863003941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863003942	dimer interface [polypeptide binding]; other site
452863003943	conserved gate region; other site
452863003944	putative PBP binding loops; other site
452863003945	ABC-ATPase subunit interface; other site
452863003946	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863003947	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863003948	substrate binding pocket [chemical binding]; other site
452863003949	membrane-bound complex binding site; other site
452863003950	hinge residues; other site
452863003951	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
452863003952	Amidase; Region: Amidase; cl11426
452863003953	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
452863003954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003955	DNA-binding site [nucleotide binding]; DNA binding site
452863003956	FCD domain; Region: FCD; pfam07729
452863003957	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
452863003958	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
452863003959	PhoD-like phosphatase; Region: PhoD; pfam09423
452863003960	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
452863003961	putative active site [active]
452863003962	putative metal binding site [ion binding]; other site
452863003963	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
452863003964	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
452863003965	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863003966	DNA-binding site [nucleotide binding]; DNA binding site
452863003967	RNA-binding motif; other site
452863003968	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
452863003969	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863003970	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003971	DNA-binding site [nucleotide binding]; DNA binding site
452863003972	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
452863003973	AAA domain; Region: AAA_33; pfam13671
452863003974	ATP-binding site [chemical binding]; other site
452863003975	Gluconate-6-phosphate binding site [chemical binding]; other site
452863003976	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
452863003977	fructuronate transporter; Provisional; Region: PRK10034; cl15264
452863003978	short chain dehydrogenase; Provisional; Region: PRK06197
452863003979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863003980	NAD(P) binding site [chemical binding]; other site
452863003981	active site
452863003982	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
452863003983	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863003984	DNA-binding site [nucleotide binding]; DNA binding site
452863003985	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863003986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863003987	homodimer interface [polypeptide binding]; other site
452863003988	catalytic residue [active]
452863003989	EamA-like transporter family; Region: EamA; pfam00892
452863003990	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
452863003991	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
452863003992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863003993	S-adenosylmethionine binding site [chemical binding]; other site
452863003994	S-methylmethionine transporter; Provisional; Region: PRK11387
452863003995	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863003996	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863003997	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863003998	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
452863003999	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863004000	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
452863004001	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
452863004002	RibD C-terminal domain; Region: RibD_C; cl17279
452863004003	Bacitracin resistance protein BacA; Region: BacA; cl00858
452863004004	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
452863004005	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
452863004006	putative active site [active]
452863004007	heme pocket [chemical binding]; other site
452863004008	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
452863004009	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
452863004010	metal binding site [ion binding]; metal-binding site
452863004011	active site
452863004012	I-site; other site
452863004013	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
452863004014	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863004015	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
452863004016	active site
452863004017	motif I; other site
452863004018	motif II; other site
452863004019	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863004020	Peptidase M15; Region: Peptidase_M15_3; cl01194
452863004021	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
452863004022	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
452863004023	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
452863004024	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
452863004025	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
452863004026	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
452863004027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863004028	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
452863004029	PRC-barrel domain; Region: PRC; pfam05239
452863004030	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
452863004031	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
452863004032	active site
452863004033	substrate binding site [chemical binding]; other site
452863004034	cosubstrate binding site; other site
452863004035	catalytic site [active]
452863004036	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863004037	putative active site [active]
452863004038	benzoate transport; Region: 2A0115; TIGR00895
452863004039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004040	putative substrate translocation pore; other site
452863004041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004042	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
452863004043	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
452863004044	purine monophosphate binding site [chemical binding]; other site
452863004045	dimer interface [polypeptide binding]; other site
452863004046	putative catalytic residues [active]
452863004047	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
452863004048	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
452863004049	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
452863004050	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
452863004051	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863004052	Catalytic domain of Protein Kinases; Region: PKc; cd00180
452863004053	active site
452863004054	ATP binding site [chemical binding]; other site
452863004055	substrate binding site [chemical binding]; other site
452863004056	activation loop (A-loop); other site
452863004057	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863004058	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863004059	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863004060	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863004061	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
452863004062	Walker A/P-loop; other site
452863004063	ATP binding site [chemical binding]; other site
452863004064	Q-loop/lid; other site
452863004065	ABC transporter signature motif; other site
452863004066	Walker B; other site
452863004067	D-loop; other site
452863004068	H-loop/switch region; other site
452863004069	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
452863004070	FtsX-like permease family; Region: FtsX; pfam02687
452863004071	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
452863004072	Amb_all domain; Region: Amb_all; smart00656
452863004073	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
452863004074	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
452863004075	putative ligand binding site [chemical binding]; other site
452863004076	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863004077	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
452863004078	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863004079	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
452863004080	TM-ABC transporter signature motif; other site
452863004081	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
452863004082	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
452863004083	Walker A/P-loop; other site
452863004084	ATP binding site [chemical binding]; other site
452863004085	Q-loop/lid; other site
452863004086	ABC transporter signature motif; other site
452863004087	Walker B; other site
452863004088	D-loop; other site
452863004089	H-loop/switch region; other site
452863004090	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
452863004091	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863004092	dimerization interface [polypeptide binding]; other site
452863004093	putative DNA binding site [nucleotide binding]; other site
452863004094	Transcriptional regulators [Transcription]; Region: MarR; COG1846
452863004095	putative Zn2+ binding site [ion binding]; other site
452863004096	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863004097	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
452863004098	nucleotide binding site [chemical binding]; other site
452863004099	Predicted amidohydrolase [General function prediction only]; Region: COG0388
452863004100	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
452863004101	active site
452863004102	catalytic triad [active]
452863004103	dimer interface [polypeptide binding]; other site
452863004104	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
452863004105	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
452863004106	amino acid transporter; Region: 2A0306; TIGR00909
452863004107	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
452863004108	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863004109	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
452863004110	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
452863004111	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
452863004112	trimer interface [polypeptide binding]; other site
452863004113	putative metal binding site [ion binding]; other site
452863004114	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
452863004115	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
452863004116	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
452863004117	putative active site [active]
452863004118	putative substrate binding site [chemical binding]; other site
452863004119	putative cosubstrate binding site; other site
452863004120	catalytic site [active]
452863004121	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
452863004122	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
452863004123	dimer interface [polypeptide binding]; other site
452863004124	active site
452863004125	glycine-pyridoxal phosphate binding site [chemical binding]; other site
452863004126	folate binding site [chemical binding]; other site
452863004127	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
452863004128	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
452863004129	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
452863004130	homodimer interface [polypeptide binding]; other site
452863004131	NADP binding site [chemical binding]; other site
452863004132	substrate binding site [chemical binding]; other site
452863004133	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863004134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863004135	Walker A/P-loop; other site
452863004136	ATP binding site [chemical binding]; other site
452863004137	Q-loop/lid; other site
452863004138	ABC transporter signature motif; other site
452863004139	Walker B; other site
452863004140	D-loop; other site
452863004141	H-loop/switch region; other site
452863004142	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
452863004143	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
452863004144	ABC-2 type transporter; Region: ABC2_membrane; cl17235
452863004145	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
452863004146	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
452863004147	putative active site [active]
452863004148	putative catalytic site [active]
452863004149	putative DNA binding site [nucleotide binding]; other site
452863004150	putative phosphate binding site [ion binding]; other site
452863004151	metal binding site A [ion binding]; metal-binding site
452863004152	putative AP binding site [nucleotide binding]; other site
452863004153	putative metal binding site B [ion binding]; other site
452863004154	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
452863004155	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
452863004156	active site
452863004157	HIGH motif; other site
452863004158	dimer interface [polypeptide binding]; other site
452863004159	KMSKS motif; other site
452863004160	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
452863004161	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
452863004162	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
452863004163	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863004164	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863004165	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863004166	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
452863004167	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
452863004168	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
452863004169	L-aspartate oxidase; Provisional; Region: PRK06175
452863004170	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
452863004171	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
452863004172	putative Iron-sulfur protein interface [polypeptide binding]; other site
452863004173	putative proximal heme binding site [chemical binding]; other site
452863004174	putative SdhC-like subunit interface [polypeptide binding]; other site
452863004175	putative distal heme binding site [chemical binding]; other site
452863004176	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
452863004177	putative Iron-sulfur protein interface [polypeptide binding]; other site
452863004178	putative proximal heme binding site [chemical binding]; other site
452863004179	putative SdhD-like interface [polypeptide binding]; other site
452863004180	putative distal heme binding site [chemical binding]; other site
452863004181	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
452863004182	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
452863004183	Substrate binding site; other site
452863004184	Cupin domain; Region: Cupin_2; cl17218
452863004185	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
452863004186	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
452863004187	metal binding site [ion binding]; metal-binding site
452863004188	putative dimer interface [polypeptide binding]; other site
452863004189	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863004190	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863004191	putative DNA binding site [nucleotide binding]; other site
452863004192	putative Zn2+ binding site [ion binding]; other site
452863004193	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
452863004194	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
452863004195	Prostaglandin dehydrogenases; Region: PGDH; cd05288
452863004196	NAD(P) binding site [chemical binding]; other site
452863004197	substrate binding site [chemical binding]; other site
452863004198	dimer interface [polypeptide binding]; other site
452863004199	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
452863004200	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
452863004201	ligand binding site [chemical binding]; other site
452863004202	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
452863004203	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
452863004204	Walker A/P-loop; other site
452863004205	ATP binding site [chemical binding]; other site
452863004206	Q-loop/lid; other site
452863004207	ABC transporter signature motif; other site
452863004208	Walker B; other site
452863004209	D-loop; other site
452863004210	H-loop/switch region; other site
452863004211	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
452863004212	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863004213	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
452863004214	TM-ABC transporter signature motif; other site
452863004215	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863004216	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
452863004217	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
452863004218	TM-ABC transporter signature motif; other site
452863004219	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
452863004220	active site
452863004221	catalytic motif [active]
452863004222	Zn binding site [ion binding]; other site
452863004223	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
452863004224	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
452863004225	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
452863004226	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
452863004227	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863004228	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
452863004229	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863004230	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
452863004231	adenosine deaminase; Provisional; Region: PRK09358
452863004232	active site
452863004233	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
452863004234	homodimer interface [polypeptide binding]; other site
452863004235	metal binding site [ion binding]; metal-binding site
452863004236	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
452863004237	enolase; Provisional; Region: eno; PRK00077
452863004238	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
452863004239	dimer interface [polypeptide binding]; other site
452863004240	metal binding site [ion binding]; metal-binding site
452863004241	substrate binding pocket [chemical binding]; other site
452863004242	Septum formation initiator; Region: DivIC; pfam04977
452863004243	Protein of unknown function (DUF501); Region: DUF501; pfam04417
452863004244	exopolyphosphatase; Region: exo_poly_only; TIGR03706
452863004245	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
452863004246	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
452863004247	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
452863004248	active site
452863004249	catalytic residues [active]
452863004250	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
452863004251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863004252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
452863004253	ACT domain; Region: ACT_3; pfam10000
452863004254	Family description; Region: ACT_7; pfam13840
452863004255	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
452863004256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863004257	Coenzyme A binding pocket [chemical binding]; other site
452863004258	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
452863004259	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863004260	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
452863004261	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
452863004262	Walker A/P-loop; other site
452863004263	ATP binding site [chemical binding]; other site
452863004264	Q-loop/lid; other site
452863004265	ABC transporter signature motif; other site
452863004266	Walker B; other site
452863004267	D-loop; other site
452863004268	H-loop/switch region; other site
452863004269	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
452863004270	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
452863004271	Walker A/P-loop; other site
452863004272	ATP binding site [chemical binding]; other site
452863004273	Q-loop/lid; other site
452863004274	ABC transporter signature motif; other site
452863004275	Walker B; other site
452863004276	D-loop; other site
452863004277	H-loop/switch region; other site
452863004278	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
452863004279	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
452863004280	TM-ABC transporter signature motif; other site
452863004281	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
452863004282	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
452863004283	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
452863004284	TM-ABC transporter signature motif; other site
452863004285	Bax inhibitor 1 like; Region: BaxI_1; cl17691
452863004286	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
452863004287	mevalonate kinase; Region: mevalon_kin; TIGR00549
452863004288	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
452863004289	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
452863004290	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
452863004291	dimer interface [polypeptide binding]; other site
452863004292	active site
452863004293	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
452863004294	active site
452863004295	catalytic residues [active]
452863004296	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
452863004297	Domain of unknown function DUF20; Region: UPF0118; pfam01594
452863004298	threonine dehydratase; Provisional; Region: PRK08198
452863004299	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
452863004300	tetramer interface [polypeptide binding]; other site
452863004301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863004302	catalytic residue [active]
452863004303	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
452863004304	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
452863004305	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
452863004306	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
452863004307	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
452863004308	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
452863004309	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
452863004310	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
452863004311	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
452863004312	catalytic residue [active]
452863004313	putative FPP diphosphate  binding site; other site
452863004314	putative FPP binding hydrophobic cleft; other site
452863004315	dimer interface [polypeptide binding]; other site
452863004316	putative IPP diphosphate binding site; other site
452863004317	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
452863004318	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
452863004319	putative active site [active]
452863004320	PhoH-like protein; Region: PhoH; pfam02562
452863004321	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863004322	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
452863004323	nudix motif; other site
452863004324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004325	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863004326	putative substrate translocation pore; other site
452863004327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863004328	fumarate hydratase; Reviewed; Region: fumC; PRK00485
452863004329	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
452863004330	active sites [active]
452863004331	tetramer interface [polypeptide binding]; other site
452863004332	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
452863004333	active site clefts [active]
452863004334	zinc binding site [ion binding]; other site
452863004335	dimer interface [polypeptide binding]; other site
452863004336	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
452863004337	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
452863004338	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
452863004339	putative active site [active]
452863004340	FemAB family; Region: FemAB; pfam02388
452863004341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
452863004342	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
452863004343	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
452863004344	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
452863004345	Transcriptional regulator [Transcription]; Region: LytR; COG1316
452863004346	AIR carboxylase; Region: AIRC; pfam00731
452863004347	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
452863004348	ATP-grasp domain; Region: ATP-grasp; pfam02222
452863004349	Predicted membrane protein [Function unknown]; Region: COG2246
452863004350	GtrA-like protein; Region: GtrA; pfam04138
452863004351	TIGR03089 family protein; Region: TIGR03089
452863004352	Transcription factor WhiB; Region: Whib; pfam02467
452863004353	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
452863004354	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863004355	active site
452863004356	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
452863004357	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
452863004358	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
452863004359	Trm112p-like protein; Region: Trm112p; cl01066
452863004360	Adenosylhomocysteinase; Provisional; Region: PTZ00075
452863004361	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
452863004362	homotetramer interface [polypeptide binding]; other site
452863004363	ligand binding site [chemical binding]; other site
452863004364	catalytic site [active]
452863004365	NAD binding site [chemical binding]; other site
452863004366	Bacterial Ig-like domain; Region: Big_5; pfam13205
452863004367	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
452863004368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
452863004369	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
452863004370	RDD family; Region: RDD; pfam06271
452863004371	Integral membrane protein DUF95; Region: DUF95; pfam01944
452863004372	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
452863004373	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
452863004374	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
452863004375	acyl-activating enzyme (AAE) consensus motif; other site
452863004376	putative AMP binding site [chemical binding]; other site
452863004377	putative active site [active]
452863004378	putative CoA binding site [chemical binding]; other site
452863004379	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
452863004380	Predicted methyltransferases [General function prediction only]; Region: COG0313
452863004381	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
452863004382	putative SAM binding site [chemical binding]; other site
452863004383	putative homodimer interface [polypeptide binding]; other site
452863004384	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863004385	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
452863004386	tetramerization interface [polypeptide binding]; other site
452863004387	NAD(P) binding site [chemical binding]; other site
452863004388	catalytic residues [active]
452863004389	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
452863004390	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
452863004391	Protein of unknown function DUF58; Region: DUF58; pfam01882
452863004392	MoxR-like ATPases [General function prediction only]; Region: COG0714
452863004393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863004394	Walker A motif; other site
452863004395	ATP binding site [chemical binding]; other site
452863004396	Walker B motif; other site
452863004397	arginine finger; other site
452863004398	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
452863004399	active site
452863004400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
452863004401	Domain of unknown function (DUF348); Region: DUF348; pfam03990
452863004402	Domain of unknown function (DUF348); Region: DUF348; pfam03990
452863004403	G5 domain; Region: G5; pfam07501
452863004404	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
452863004405	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
452863004406	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
452863004407	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
452863004408	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
452863004409	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
452863004410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863004411	ABC transporter; Region: ABC_tran_2; pfam12848
452863004412	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863004413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863004414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863004415	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
452863004416	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
452863004417	Substrate binding site; other site
452863004418	Mg++ binding site; other site
452863004419	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
452863004420	active site
452863004421	substrate binding site [chemical binding]; other site
452863004422	CoA binding site [chemical binding]; other site
452863004423	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
452863004424	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
452863004425	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863004426	active site
452863004427	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
452863004428	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
452863004429	5S rRNA interface [nucleotide binding]; other site
452863004430	CTC domain interface [polypeptide binding]; other site
452863004431	L16 interface [polypeptide binding]; other site
452863004432	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
452863004433	putative active site [active]
452863004434	catalytic residue [active]
452863004435	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863004436	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863004437	DNA binding residues [nucleotide binding]
452863004438	dimerization interface [polypeptide binding]; other site
452863004439	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863004440	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863004441	DNA binding residues [nucleotide binding]
452863004442	dimerization interface [polypeptide binding]; other site
452863004443	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
452863004444	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
452863004445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863004446	catalytic residue [active]
452863004447	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
452863004448	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
452863004449	trimerization site [polypeptide binding]; other site
452863004450	active site
452863004451	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
452863004452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863004453	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
452863004454	NAD(P) binding site [chemical binding]; other site
452863004455	active site
452863004456	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
452863004457	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
452863004458	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
452863004459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863004460	ATP binding site [chemical binding]; other site
452863004461	putative Mg++ binding site [ion binding]; other site
452863004462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863004463	nucleotide binding region [chemical binding]; other site
452863004464	ATP-binding site [chemical binding]; other site
452863004465	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
452863004466	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
452863004467	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
452863004468	intersubunit interface [polypeptide binding]; other site
452863004469	active site
452863004470	catalytic residue [active]
452863004471	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
452863004472	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
452863004473	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
452863004474	active site
452863004475	DNA binding site [nucleotide binding]
452863004476	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
452863004477	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
452863004478	active site
452863004479	SAM binding site [chemical binding]; other site
452863004480	homodimer interface [polypeptide binding]; other site
452863004481	nitrite reductase subunit NirD; Provisional; Region: PRK14989
452863004482	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
452863004483	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
452863004484	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
452863004485	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
452863004486	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
452863004487	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
452863004488	active site
452863004489	substrate binding site [chemical binding]; other site
452863004490	metal binding site [ion binding]; metal-binding site
452863004491	purine nucleoside phosphorylase; Provisional; Region: PRK08202
452863004492	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
452863004493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863004494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863004495	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863004496	PspC domain; Region: PspC; cl00864
452863004497	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
452863004498	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
452863004499	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
452863004500	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
452863004501	[4Fe-4S] binding site [ion binding]; other site
452863004502	molybdopterin cofactor binding site; other site
452863004503	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
452863004504	molybdopterin cofactor binding site; other site
452863004505	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
452863004506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004507	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863004508	putative substrate translocation pore; other site
452863004509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004510	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
452863004511	catalytic triad [active]
452863004512	SnoaL-like domain; Region: SnoaL_3; pfam13474
452863004513	Maf-like protein; Region: Maf; pfam02545
452863004514	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
452863004515	active site
452863004516	dimer interface [polypeptide binding]; other site
452863004517	MMPL family; Region: MMPL; pfam03176
452863004518	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
452863004519	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
452863004520	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863004521	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
452863004522	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
452863004523	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
452863004524	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
452863004525	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
452863004526	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
452863004527	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
452863004528	short chain dehydrogenase; Provisional; Region: PRK08278
452863004529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863004530	NAD(P) binding site [chemical binding]; other site
452863004531	active site
452863004532	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
452863004533	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
452863004534	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
452863004535	Bacterial PH domain; Region: DUF304; pfam03703
452863004536	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
452863004537	cyclase homology domain; Region: CHD; cd07302
452863004538	nucleotidyl binding site; other site
452863004539	metal binding site [ion binding]; metal-binding site
452863004540	dimer interface [polypeptide binding]; other site
452863004541	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863004542	Interdomain contacts; other site
452863004543	Cytokine receptor motif; other site
452863004544	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863004545	Interdomain contacts; other site
452863004546	Cytokine receptor motif; other site
452863004547	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863004548	Interdomain contacts; other site
452863004549	Cytokine receptor motif; other site
452863004550	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863004551	Interdomain contacts; other site
452863004552	Cytokine receptor motif; other site
452863004553	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863004554	Interdomain contacts; other site
452863004555	Cytokine receptor motif; other site
452863004556	MoxR-like ATPases [General function prediction only]; Region: COG0714
452863004557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863004558	Walker A motif; other site
452863004559	ATP binding site [chemical binding]; other site
452863004560	Walker B motif; other site
452863004561	arginine finger; other site
452863004562	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
452863004563	Protein of unknown function DUF58; Region: DUF58; pfam01882
452863004564	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
452863004565	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
452863004566	RDD family; Region: RDD; pfam06271
452863004567	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
452863004568	Protein phosphatase 2C; Region: PP2C; pfam00481
452863004569	active site
452863004570	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
452863004571	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863004572	Catalytic domain of Protein Kinases; Region: PKc; cd00180
452863004573	active site
452863004574	ATP binding site [chemical binding]; other site
452863004575	substrate binding site [chemical binding]; other site
452863004576	activation loop (A-loop); other site
452863004577	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
452863004578	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
452863004579	phosphopeptide binding site; other site
452863004580	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
452863004581	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863004582	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863004583	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
452863004584	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
452863004585	nucleotide binding pocket [chemical binding]; other site
452863004586	K-X-D-G motif; other site
452863004587	catalytic site [active]
452863004588	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
452863004589	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
452863004590	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
452863004591	Dimer interface [polypeptide binding]; other site
452863004592	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
452863004593	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
452863004594	active site
452863004595	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
452863004596	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863004597	Coenzyme A binding pocket [chemical binding]; other site
452863004598	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
452863004599	homotrimer interaction site [polypeptide binding]; other site
452863004600	putative active site [active]
452863004601	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
452863004602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
452863004603	active site
452863004604	phosphorylation site [posttranslational modification]
452863004605	intermolecular recognition site; other site
452863004606	dimerization interface [polypeptide binding]; other site
452863004607	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863004608	PAS fold; Region: PAS; pfam00989
452863004609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
452863004610	putative active site [active]
452863004611	heme pocket [chemical binding]; other site
452863004612	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
452863004613	Citrate transporter; Region: CitMHS; pfam03600
452863004614	Citrate transporter; Region: CitMHS; pfam03600
452863004615	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
452863004616	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
452863004617	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
452863004618	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
452863004619	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
452863004620	GatB domain; Region: GatB_Yqey; smart00845
452863004621	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863004622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863004623	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
452863004624	putative dimerization interface [polypeptide binding]; other site
452863004625	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
452863004626	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
452863004627	NAD(P) binding site [chemical binding]; other site
452863004628	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
452863004629	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
452863004630	substrate-cofactor binding pocket; other site
452863004631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863004632	catalytic residue [active]
452863004633	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
452863004634	imidazolonepropionase; Provisional; Region: PRK14085
452863004635	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863004636	active site
452863004637	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
452863004638	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
452863004639	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
452863004640	CAAX protease self-immunity; Region: Abi; pfam02517
452863004641	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
452863004642	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
452863004643	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
452863004644	homodimer interface [polypeptide binding]; other site
452863004645	substrate-cofactor binding pocket; other site
452863004646	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863004647	catalytic residue [active]
452863004648	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
452863004649	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
452863004650	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
452863004651	active site
452863004652	catalytic triad [active]
452863004653	oxyanion hole [active]
452863004654	putative hydrolase; Provisional; Region: PRK11460
452863004655	Predicted esterase [General function prediction only]; Region: COG0400
452863004656	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863004657	RNA binding surface [nucleotide binding]; other site
452863004658	Protein of unknown function, DUF606; Region: DUF606; pfam04657
452863004659	Protein of unknown function, DUF606; Region: DUF606; pfam04657
452863004660	glycyl-tRNA synthetase; Provisional; Region: PRK04173
452863004661	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
452863004662	motif 1; other site
452863004663	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
452863004664	active site
452863004665	motif 2; other site
452863004666	motif 3; other site
452863004667	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
452863004668	anticodon binding site; other site
452863004669	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
452863004670	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
452863004671	putative acyl-acceptor binding pocket; other site
452863004672	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863004673	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
452863004674	catalytic site [active]
452863004675	YibE/F-like protein; Region: YibE_F; pfam07907
452863004676	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
452863004677	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
452863004678	FMN binding site [chemical binding]; other site
452863004679	active site
452863004680	catalytic residues [active]
452863004681	substrate binding site [chemical binding]; other site
452863004682	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
452863004683	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
452863004684	Zn2+ binding site [ion binding]; other site
452863004685	Mg2+ binding site [ion binding]; other site
452863004686	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
452863004687	DNA primase; Validated; Region: dnaG; PRK05667
452863004688	CHC2 zinc finger; Region: zf-CHC2; pfam01807
452863004689	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
452863004690	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
452863004691	active site
452863004692	metal binding site [ion binding]; metal-binding site
452863004693	interdomain interaction site; other site
452863004694	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
452863004695	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
452863004696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863004697	putative substrate translocation pore; other site
452863004698	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
452863004699	Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653
452863004700	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
452863004701	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863004702	putative ADP-binding pocket [chemical binding]; other site
452863004703	acyl-coenzyme A oxidase; Region: PLN02526
452863004704	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863004705	active site
452863004706	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863004707	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863004708	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
452863004709	rRNA interaction site [nucleotide binding]; other site
452863004710	S8 interaction site; other site
452863004711	putative laminin-1 binding site; other site
452863004712	elongation factor Ts; Provisional; Region: tsf; PRK09377
452863004713	UBA/TS-N domain; Region: UBA; pfam00627
452863004714	Elongation factor TS; Region: EF_TS; pfam00889
452863004715	Elongation factor TS; Region: EF_TS; pfam00889
452863004716	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
452863004717	putative nucleotide binding site [chemical binding]; other site
452863004718	uridine monophosphate binding site [chemical binding]; other site
452863004719	homohexameric interface [polypeptide binding]; other site
452863004720	ribosome recycling factor; Reviewed; Region: frr; PRK00083
452863004721	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
452863004722	hinge region; other site
452863004723	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
452863004724	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
452863004725	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
452863004726	DivIVA domain; Region: DivI1A_domain; TIGR03544
452863004727	DivIVA domain; Region: DivI1A_domain; TIGR03544
452863004728	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
452863004729	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
452863004730	Na binding site [ion binding]; other site
452863004731	Protein of unknown function, DUF485; Region: DUF485; pfam04341
452863004732	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
452863004733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863004734	active site
452863004735	phosphorylation site [posttranslational modification]
452863004736	intermolecular recognition site; other site
452863004737	dimerization interface [polypeptide binding]; other site
452863004738	LytTr DNA-binding domain; Region: LytTR; smart00850
452863004739	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
452863004740	Histidine kinase; Region: His_kinase; pfam06580
452863004741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863004742	ATP binding site [chemical binding]; other site
452863004743	Mg2+ binding site [ion binding]; other site
452863004744	G-X-G motif; other site
452863004745	Protein of unknown function, DUF485; Region: DUF485; pfam04341
452863004746	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
452863004747	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
452863004748	Na binding site [ion binding]; other site
452863004749	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863004750	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
452863004751	putative DNA binding site [nucleotide binding]; other site
452863004752	putative Zn2+ binding site [ion binding]; other site
452863004753	AsnC family; Region: AsnC_trans_reg; pfam01037
452863004754	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
452863004755	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
452863004756	tetramer interface [polypeptide binding]; other site
452863004757	TPP-binding site [chemical binding]; other site
452863004758	heterodimer interface [polypeptide binding]; other site
452863004759	phosphorylation loop region [posttranslational modification]
452863004760	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
452863004761	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
452863004762	alpha subunit interface [polypeptide binding]; other site
452863004763	TPP binding site [chemical binding]; other site
452863004764	heterodimer interface [polypeptide binding]; other site
452863004765	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863004766	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
452863004767	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
452863004768	E3 interaction surface; other site
452863004769	lipoyl attachment site [posttranslational modification]; other site
452863004770	e3 binding domain; Region: E3_binding; pfam02817
452863004771	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
452863004772	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863004773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863004774	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
452863004775	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
452863004776	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
452863004777	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
452863004778	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
452863004779	ATP-grasp domain; Region: ATP-grasp_4; cl17255
452863004780	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
452863004781	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
452863004782	carboxyltransferase (CT) interaction site; other site
452863004783	biotinylation site [posttranslational modification]; other site
452863004784	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
452863004785	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863004786	active site
452863004787	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
452863004788	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
452863004789	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
452863004790	putative active site [active]
452863004791	putative catalytic site [active]
452863004792	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
452863004793	Lipase maturation factor; Region: LMF1; pfam06762
452863004794	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
452863004795	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
452863004796	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
452863004797	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
452863004798	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
452863004799	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
452863004800	active site
452863004801	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
452863004802	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
452863004803	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
452863004804	putative substrate binding region [chemical binding]; other site
452863004805	putative substrate binding region [chemical binding]; other site
452863004806	YCII-related domain; Region: YCII; cl00999
452863004807	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
452863004808	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
452863004809	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
452863004810	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
452863004811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863004812	prolyl-tRNA synthetase; Provisional; Region: PRK09194
452863004813	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
452863004814	dimer interface [polypeptide binding]; other site
452863004815	motif 1; other site
452863004816	active site
452863004817	motif 2; other site
452863004818	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
452863004819	putative deacylase active site [active]
452863004820	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
452863004821	active site
452863004822	motif 3; other site
452863004823	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
452863004824	anticodon binding site; other site
452863004825	hypothetical protein; Provisional; Region: PRK10621
452863004826	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
452863004827	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863004828	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863004829	catalytic residue [active]
452863004830	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
452863004831	ribosome maturation protein RimP; Reviewed; Region: PRK00092
452863004832	Sm and related proteins; Region: Sm_like; cl00259
452863004833	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
452863004834	putative oligomer interface [polypeptide binding]; other site
452863004835	putative RNA binding site [nucleotide binding]; other site
452863004836	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
452863004837	NusA N-terminal domain; Region: NusA_N; pfam08529
452863004838	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
452863004839	RNA binding site [nucleotide binding]; other site
452863004840	homodimer interface [polypeptide binding]; other site
452863004841	NusA-like KH domain; Region: KH_5; pfam13184
452863004842	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
452863004843	G-X-X-G motif; other site
452863004844	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
452863004845	translation initiation factor IF-2; Region: IF-2; TIGR00487
452863004846	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
452863004847	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
452863004848	G1 box; other site
452863004849	putative GEF interaction site [polypeptide binding]; other site
452863004850	GTP/Mg2+ binding site [chemical binding]; other site
452863004851	Switch I region; other site
452863004852	G2 box; other site
452863004853	G3 box; other site
452863004854	Switch II region; other site
452863004855	G4 box; other site
452863004856	G5 box; other site
452863004857	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
452863004858	Translation-initiation factor 2; Region: IF-2; pfam11987
452863004859	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
452863004860	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
452863004861	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
452863004862	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
452863004863	nucleoside/Zn binding site; other site
452863004864	dimer interface [polypeptide binding]; other site
452863004865	catalytic motif [active]
452863004866	thioredoxin 2; Provisional; Region: PRK10996
452863004867	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863004868	catalytic residues [active]
452863004869	aspartate aminotransferase; Provisional; Region: PRK05764
452863004870	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863004871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863004872	homodimer interface [polypeptide binding]; other site
452863004873	catalytic residue [active]
452863004874	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
452863004875	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
452863004876	RNA binding site [nucleotide binding]; other site
452863004877	active site
452863004878	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
452863004879	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
452863004880	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
452863004881	active site
452863004882	Riboflavin kinase; Region: Flavokinase; smart00904
452863004883	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
452863004884	kynureninase; Region: kynureninase; TIGR01814
452863004885	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863004886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863004887	catalytic residue [active]
452863004888	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
452863004889	16S/18S rRNA binding site [nucleotide binding]; other site
452863004890	S13e-L30e interaction site [polypeptide binding]; other site
452863004891	25S rRNA binding site [nucleotide binding]; other site
452863004892	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
452863004893	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
452863004894	oligomer interface [polypeptide binding]; other site
452863004895	RNA binding site [nucleotide binding]; other site
452863004896	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
452863004897	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
452863004898	RNase E interface [polypeptide binding]; other site
452863004899	trimer interface [polypeptide binding]; other site
452863004900	active site
452863004901	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
452863004902	putative nucleic acid binding region [nucleotide binding]; other site
452863004903	G-X-X-G motif; other site
452863004904	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
452863004905	RNA binding site [nucleotide binding]; other site
452863004906	domain interface; other site
452863004907	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
452863004908	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
452863004909	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
452863004910	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
452863004911	Ubiquitin-like proteins; Region: UBQ; cl00155
452863004912	charged pocket; other site
452863004913	hydrophobic patch; other site
452863004914	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
452863004915	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863004916	FeS/SAM binding site; other site
452863004917	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
452863004918	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
452863004919	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
452863004920	Moco binding site; other site
452863004921	metal coordination site [ion binding]; other site
452863004922	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
452863004923	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
452863004924	dimer interface [polypeptide binding]; other site
452863004925	putative functional site; other site
452863004926	putative MPT binding site; other site
452863004927	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
452863004928	trimer interface [polypeptide binding]; other site
452863004929	dimer interface [polypeptide binding]; other site
452863004930	putative active site [active]
452863004931	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
452863004932	MPT binding site; other site
452863004933	trimer interface [polypeptide binding]; other site
452863004934	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
452863004935	MoaE homodimer interface [polypeptide binding]; other site
452863004936	MoaD interaction [polypeptide binding]; other site
452863004937	active site residues [active]
452863004938	dihydrodipicolinate reductase; Provisional; Region: PRK00048
452863004939	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
452863004940	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
452863004941	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
452863004942	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
452863004943	dimer interface [polypeptide binding]; other site
452863004944	active site
452863004945	catalytic residue [active]
452863004946	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
452863004947	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863004948	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
452863004949	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
452863004950	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
452863004951	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863004952	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
452863004953	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
452863004954	Competence-damaged protein; Region: CinA; pfam02464
452863004955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863004956	non-specific DNA binding site [nucleotide binding]; other site
452863004957	salt bridge; other site
452863004958	sequence-specific DNA binding site [nucleotide binding]; other site
452863004959	Transcriptional regulators [Transcription]; Region: MarR; COG1846
452863004960	MarR family; Region: MarR_2; pfam12802
452863004961	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
452863004962	recombinase A; Provisional; Region: recA; PRK09354
452863004963	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
452863004964	hexamer interface [polypeptide binding]; other site
452863004965	Walker A motif; other site
452863004966	ATP binding site [chemical binding]; other site
452863004967	Walker B motif; other site
452863004968	recombination regulator RecX; Reviewed; Region: recX; PRK00117
452863004969	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
452863004970	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
452863004971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863004972	FeS/SAM binding site; other site
452863004973	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
452863004974	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
452863004975	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
452863004976	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
452863004977	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
452863004978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863004979	S-adenosylmethionine binding site [chemical binding]; other site
452863004980	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
452863004981	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
452863004982	HflX GTPase family; Region: HflX; cd01878
452863004983	G1 box; other site
452863004984	GTP/Mg2+ binding site [chemical binding]; other site
452863004985	Switch I region; other site
452863004986	G2 box; other site
452863004987	G3 box; other site
452863004988	Switch II region; other site
452863004989	G4 box; other site
452863004990	G5 box; other site
452863004991	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
452863004992	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
452863004993	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
452863004994	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
452863004995	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
452863004996	LexA repressor; Validated; Region: PRK00215
452863004997	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
452863004998	Catalytic site [active]
452863004999	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863005000	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
452863005001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863005002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863005003	homodimer interface [polypeptide binding]; other site
452863005004	catalytic residue [active]
452863005005	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
452863005006	putative active site pocket [active]
452863005007	4-fold oligomerization interface [polypeptide binding]; other site
452863005008	metal binding residues [ion binding]; metal-binding site
452863005009	3-fold/trimer interface [polypeptide binding]; other site
452863005010	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
452863005011	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
452863005012	putative active site [active]
452863005013	oxyanion strand; other site
452863005014	catalytic triad [active]
452863005015	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
452863005016	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
452863005017	catalytic residues [active]
452863005018	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863005019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863005020	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
452863005021	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
452863005022	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
452863005023	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
452863005024	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
452863005025	23S rRNA binding site [nucleotide binding]; other site
452863005026	L21 binding site [polypeptide binding]; other site
452863005027	L13 binding site [polypeptide binding]; other site
452863005028	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
452863005029	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
452863005030	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
452863005031	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
452863005032	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
452863005033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863005034	putative substrate translocation pore; other site
452863005035	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
452863005036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863005037	Radical SAM superfamily; Region: Radical_SAM; pfam04055
452863005038	FeS/SAM binding site; other site
452863005039	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
452863005040	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
452863005041	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
452863005042	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
452863005043	dimer interface [polypeptide binding]; other site
452863005044	motif 1; other site
452863005045	active site
452863005046	motif 2; other site
452863005047	motif 3; other site
452863005048	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
452863005049	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
452863005050	putative tRNA-binding site [nucleotide binding]; other site
452863005051	B3/4 domain; Region: B3_4; pfam03483
452863005052	tRNA synthetase B5 domain; Region: B5; pfam03484
452863005053	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
452863005054	dimer interface [polypeptide binding]; other site
452863005055	motif 1; other site
452863005056	motif 3; other site
452863005057	motif 2; other site
452863005058	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
452863005059	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
452863005060	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
452863005061	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
452863005062	Peptidase family M1; Region: Peptidase_M1; pfam01433
452863005063	Zn binding site [ion binding]; other site
452863005064	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863005065	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
452863005066	acyl-activating enzyme (AAE) consensus motif; other site
452863005067	AMP binding site [chemical binding]; other site
452863005068	active site
452863005069	CoA binding site [chemical binding]; other site
452863005070	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
452863005071	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
452863005072	putative trimer interface [polypeptide binding]; other site
452863005073	putative CoA binding site [chemical binding]; other site
452863005074	putative acyl transferase; Provisional; Region: PRK10502
452863005075	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
452863005076	putative trimer interface [polypeptide binding]; other site
452863005077	putative CoA binding site [chemical binding]; other site
452863005078	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
452863005079	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
452863005080	NADP binding site [chemical binding]; other site
452863005081	dimer interface [polypeptide binding]; other site
452863005082	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
452863005083	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
452863005084	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
452863005085	heterotetramer interface [polypeptide binding]; other site
452863005086	active site pocket [active]
452863005087	cleavage site
452863005088	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
452863005089	feedback inhibition sensing region; other site
452863005090	homohexameric interface [polypeptide binding]; other site
452863005091	nucleotide binding site [chemical binding]; other site
452863005092	N-acetyl-L-glutamate binding site [chemical binding]; other site
452863005093	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
452863005094	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
452863005095	inhibitor-cofactor binding pocket; inhibition site
452863005096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863005097	catalytic residue [active]
452863005098	ornithine carbamoyltransferase; Provisional; Region: PRK00779
452863005099	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
452863005100	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
452863005101	arginine repressor; Provisional; Region: PRK03341
452863005102	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
452863005103	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
452863005104	argininosuccinate synthase; Provisional; Region: PRK13820
452863005105	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
452863005106	ANP binding site [chemical binding]; other site
452863005107	Substrate Binding Site II [chemical binding]; other site
452863005108	Substrate Binding Site I [chemical binding]; other site
452863005109	argininosuccinate lyase; Provisional; Region: PRK00855
452863005110	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
452863005111	active sites [active]
452863005112	tetramer interface [polypeptide binding]; other site
452863005113	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
452863005114	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
452863005115	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
452863005116	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
452863005117	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
452863005118	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
452863005119	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
452863005120	DNA binding site [nucleotide binding]
452863005121	active site
452863005122	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
452863005123	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
452863005124	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863005125	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
452863005126	AlkA N-terminal domain; Region: AlkA_N; pfam06029
452863005127	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
452863005128	minor groove reading motif; other site
452863005129	helix-hairpin-helix signature motif; other site
452863005130	substrate binding pocket [chemical binding]; other site
452863005131	active site
452863005132	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
452863005133	active site
452863005134	DNA binding site [nucleotide binding]
452863005135	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
452863005136	Part of AAA domain; Region: AAA_19; pfam13245
452863005137	Family description; Region: UvrD_C_2; pfam13538
452863005138	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
452863005139	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
452863005140	active site
452863005141	HIGH motif; other site
452863005142	dimer interface [polypeptide binding]; other site
452863005143	KMSKS motif; other site
452863005144	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863005145	RNA binding surface [nucleotide binding]; other site
452863005146	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
452863005147	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
452863005148	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863005149	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863005150	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
452863005151	RNA binding surface [nucleotide binding]; other site
452863005152	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
452863005153	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
452863005154	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
452863005155	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
452863005156	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
452863005157	Walker A/P-loop; other site
452863005158	ATP binding site [chemical binding]; other site
452863005159	Q-loop/lid; other site
452863005160	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
452863005161	Q-loop/lid; other site
452863005162	ABC transporter signature motif; other site
452863005163	Walker B; other site
452863005164	D-loop; other site
452863005165	H-loop/switch region; other site
452863005166	CTP synthetase; Validated; Region: pyrG; PRK05380
452863005167	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
452863005168	Catalytic site [active]
452863005169	active site
452863005170	UTP binding site [chemical binding]; other site
452863005171	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
452863005172	active site
452863005173	putative oxyanion hole; other site
452863005174	catalytic triad [active]
452863005175	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
452863005176	dimer interface [polypeptide binding]; other site
452863005177	ADP-ribose binding site [chemical binding]; other site
452863005178	active site
452863005179	nudix motif; other site
452863005180	metal binding site [ion binding]; metal-binding site
452863005181	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
452863005182	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
452863005183	active site
452863005184	Int/Topo IB signature motif; other site
452863005185	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
452863005186	nudix motif; other site
452863005187	citrate synthase; Provisional; Region: PRK14033
452863005188	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
452863005189	oxalacetate binding site [chemical binding]; other site
452863005190	citrylCoA binding site [chemical binding]; other site
452863005191	coenzyme A binding site [chemical binding]; other site
452863005192	catalytic triad [active]
452863005193	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
452863005194	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
452863005195	tetramer interface [polypeptide binding]; other site
452863005196	active site
452863005197	Mg2+/Mn2+ binding site [ion binding]; other site
452863005198	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
452863005199	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863005200	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
452863005201	DNA-binding site [nucleotide binding]; DNA binding site
452863005202	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
452863005203	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863005204	acyl-activating enzyme (AAE) consensus motif; other site
452863005205	AMP binding site [chemical binding]; other site
452863005206	active site
452863005207	CoA binding site [chemical binding]; other site
452863005208	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
452863005209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863005210	active site
452863005211	phosphorylation site [posttranslational modification]
452863005212	intermolecular recognition site; other site
452863005213	dimerization interface [polypeptide binding]; other site
452863005214	FaeA-like protein; Region: FaeA; pfam04703
452863005215	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
452863005216	PAS domain; Region: PAS_8; pfam13188
452863005217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863005218	ATP binding site [chemical binding]; other site
452863005219	Mg2+ binding site [ion binding]; other site
452863005220	G-X-G motif; other site
452863005221	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
452863005222	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
452863005223	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863005224	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863005225	P-loop; other site
452863005226	Magnesium ion binding site [ion binding]; other site
452863005227	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863005228	Magnesium ion binding site [ion binding]; other site
452863005229	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
452863005230	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
452863005231	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
452863005232	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863005233	RNA binding surface [nucleotide binding]; other site
452863005234	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
452863005235	active site
452863005236	prephenate dehydrogenase; Validated; Region: PRK06545
452863005237	prephenate dehydrogenase; Validated; Region: PRK08507
452863005238	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
452863005239	cytidylate kinase; Provisional; Region: cmk; PRK00023
452863005240	Cytidylate kinase; Region: Cytidylate_kin; pfam02224
452863005241	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
452863005242	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
452863005243	putative acyl-acceptor binding pocket; other site
452863005244	GTP-binding protein Der; Reviewed; Region: PRK03003
452863005245	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
452863005246	G1 box; other site
452863005247	GTP/Mg2+ binding site [chemical binding]; other site
452863005248	Switch I region; other site
452863005249	G2 box; other site
452863005250	Switch II region; other site
452863005251	G3 box; other site
452863005252	G4 box; other site
452863005253	G5 box; other site
452863005254	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
452863005255	G1 box; other site
452863005256	GTP/Mg2+ binding site [chemical binding]; other site
452863005257	Switch I region; other site
452863005258	G2 box; other site
452863005259	G3 box; other site
452863005260	Switch II region; other site
452863005261	G4 box; other site
452863005262	G5 box; other site
452863005263	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
452863005264	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
452863005265	putative DNA binding site [nucleotide binding]; other site
452863005266	catalytic residue [active]
452863005267	putative H2TH interface [polypeptide binding]; other site
452863005268	putative catalytic residues [active]
452863005269	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
452863005270	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
452863005271	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
452863005272	lipoyl attachment site [posttranslational modification]; other site
452863005273	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
452863005274	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
452863005275	phosphopeptide binding site; other site
452863005276	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
452863005277	DNA binding residues [nucleotide binding]
452863005278	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863005279	dimer interface [polypeptide binding]; other site
452863005280	Bifunctional nuclease; Region: DNase-RNase; pfam02577
452863005281	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
452863005282	DNA binding residues [nucleotide binding]
452863005283	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863005284	putative dimer interface [polypeptide binding]; other site
452863005285	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863005286	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863005287	Magnesium ion binding site [ion binding]; other site
452863005288	pyruvate carboxylase; Reviewed; Region: PRK12999
452863005289	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
452863005290	ATP-grasp domain; Region: ATP-grasp_4; cl17255
452863005291	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
452863005292	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
452863005293	active site
452863005294	catalytic residues [active]
452863005295	metal binding site [ion binding]; metal-binding site
452863005296	homodimer binding site [polypeptide binding]; other site
452863005297	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
452863005298	carboxyltransferase (CT) interaction site; other site
452863005299	biotinylation site [posttranslational modification]; other site
452863005300	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
452863005301	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
452863005302	acyl-activating enzyme (AAE) consensus motif; other site
452863005303	putative AMP binding site [chemical binding]; other site
452863005304	putative active site [active]
452863005305	putative CoA binding site [chemical binding]; other site
452863005306	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
452863005307	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
452863005308	Esterase/lipase [General function prediction only]; Region: COG1647
452863005309	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
452863005310	Esterase/lipase [General function prediction only]; Region: COG1647
452863005311	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
452863005312	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
452863005313	putative acyl-acceptor binding pocket; other site
452863005314	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
452863005315	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863005316	Catalytic domain of Protein Kinases; Region: PKc; cd00180
452863005317	active site
452863005318	ATP binding site [chemical binding]; other site
452863005319	substrate binding site [chemical binding]; other site
452863005320	activation loop (A-loop); other site
452863005321	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863005322	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863005323	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863005324	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
452863005325	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863005326	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863005327	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863005328	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
452863005329	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
452863005330	N-acetyl-D-glucosamine binding site [chemical binding]; other site
452863005331	catalytic residue [active]
452863005332	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
452863005333	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
452863005334	substrate binding pocket [chemical binding]; other site
452863005335	chain length determination region; other site
452863005336	substrate-Mg2+ binding site; other site
452863005337	catalytic residues [active]
452863005338	aspartate-rich region 1; other site
452863005339	active site lid residues [active]
452863005340	aspartate-rich region 2; other site
452863005341	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
452863005342	active site
452863005343	DNA polymerase IV; Validated; Region: PRK02406
452863005344	DNA binding site [nucleotide binding]
452863005345	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
452863005346	cell division protein MraZ; Reviewed; Region: PRK00326
452863005347	MraZ protein; Region: MraZ; pfam02381
452863005348	MraZ protein; Region: MraZ; pfam02381
452863005349	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
452863005350	MraW methylase family; Region: Methyltransf_5; cl17771
452863005351	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
452863005352	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
452863005353	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
452863005354	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
452863005355	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863005356	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
452863005357	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
452863005358	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
452863005359	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863005360	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
452863005361	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
452863005362	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
452863005363	Mg++ binding site [ion binding]; other site
452863005364	putative catalytic motif [active]
452863005365	putative substrate binding site [chemical binding]; other site
452863005366	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
452863005367	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863005368	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
452863005369	cell division protein FtsW; Region: ftsW; TIGR02614
452863005370	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
452863005371	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
452863005372	active site
452863005373	homodimer interface [polypeptide binding]; other site
452863005374	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
452863005375	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
452863005376	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863005377	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
452863005378	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
452863005379	Cell division protein FtsQ; Region: FtsQ; pfam03799
452863005380	cell division protein FtsZ; Validated; Region: PRK09330
452863005381	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
452863005382	nucleotide binding site [chemical binding]; other site
452863005383	SulA interaction site; other site
452863005384	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
452863005385	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
452863005386	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
452863005387	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
452863005388	catalytic residue [active]
452863005389	Protein of unknown function (DUF552); Region: DUF552; pfam04472
452863005390	DivIVA protein; Region: DivIVA; pfam05103
452863005391	DivIVA domain; Region: DivI1A_domain; TIGR03544
452863005392	lipoprotein signal peptidase; Provisional; Region: PRK14772
452863005393	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
452863005394	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
452863005395	active site
452863005396	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
452863005397	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
452863005398	active site
452863005399	PHP Thumb interface [polypeptide binding]; other site
452863005400	metal binding site [ion binding]; metal-binding site
452863005401	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
452863005402	generic binding surface II; other site
452863005403	generic binding surface I; other site
452863005404	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
452863005405	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
452863005406	histidinol dehydrogenase; Region: hisD; TIGR00069
452863005407	NAD binding site [chemical binding]; other site
452863005408	dimerization interface [polypeptide binding]; other site
452863005409	product binding site; other site
452863005410	substrate binding site [chemical binding]; other site
452863005411	zinc binding site [ion binding]; other site
452863005412	catalytic residues [active]
452863005413	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
452863005414	ATP cone domain; Region: ATP-cone; pfam03477
452863005415	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863005416	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
452863005417	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
452863005418	active site
452863005419	Sporulation related domain; Region: SPOR; cl10051
452863005420	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
452863005421	oligomerization interface [polypeptide binding]; other site
452863005422	active site
452863005423	metal binding site [ion binding]; metal-binding site
452863005424	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
452863005425	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
452863005426	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
452863005427	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
452863005428	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
452863005429	metal binding triad; other site
452863005430	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
452863005431	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
452863005432	metal binding triad; other site
452863005433	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
452863005434	glutamine synthetase, type I; Region: GlnA; TIGR00653
452863005435	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
452863005436	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
452863005437	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
452863005438	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
452863005439	lipoyl synthase; Provisional; Region: PRK05481
452863005440	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863005441	FeS/SAM binding site; other site
452863005442	lipoate-protein ligase B; Provisional; Region: PRK14345
452863005443	Catalytic domain of Protein Kinases; Region: PKc; cd00180
452863005444	active site
452863005445	ATP binding site [chemical binding]; other site
452863005446	substrate binding site [chemical binding]; other site
452863005447	activation loop (A-loop); other site
452863005448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863005449	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
452863005450	NAD(P) binding site [chemical binding]; other site
452863005451	active site
452863005452	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
452863005453	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
452863005454	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
452863005455	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
452863005456	protein binding site [polypeptide binding]; other site
452863005457	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
452863005458	Domain interface; other site
452863005459	Peptide binding site; other site
452863005460	Active site tetrad [active]
452863005461	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
452863005462	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
452863005463	E3 interaction surface; other site
452863005464	lipoyl attachment site [posttranslational modification]; other site
452863005465	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
452863005466	E3 interaction surface; other site
452863005467	lipoyl attachment site [posttranslational modification]; other site
452863005468	e3 binding domain; Region: E3_binding; pfam02817
452863005469	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
452863005470	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
452863005471	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
452863005472	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863005473	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863005474	multifunctional aminopeptidase A; Provisional; Region: PRK00913
452863005475	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
452863005476	interface (dimer of trimers) [polypeptide binding]; other site
452863005477	Substrate-binding/catalytic site; other site
452863005478	Zn-binding sites [ion binding]; other site
452863005479	PAC2 family; Region: PAC2; pfam09754
452863005480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863005481	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863005482	putative substrate translocation pore; other site
452863005483	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
452863005484	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
452863005485	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
452863005486	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863005487	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
452863005488	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863005489	DNA binding residues [nucleotide binding]
452863005490	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
452863005491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863005492	ATP binding site [chemical binding]; other site
452863005493	Mg2+ binding site [ion binding]; other site
452863005494	G-X-G motif; other site
452863005495	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
452863005496	anchoring element; other site
452863005497	dimer interface [polypeptide binding]; other site
452863005498	ATP binding site [chemical binding]; other site
452863005499	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
452863005500	active site
452863005501	metal binding site [ion binding]; metal-binding site
452863005502	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
452863005503	Peptidase family M48; Region: Peptidase_M48; cl12018
452863005504	Penicillinase repressor; Region: Pencillinase_R; cl17580
452863005505	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
452863005506	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
452863005507	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
452863005508	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
452863005509	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863005510	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
452863005511	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
452863005512	Walker A/P-loop; other site
452863005513	ATP binding site [chemical binding]; other site
452863005514	Q-loop/lid; other site
452863005515	Walker B; other site
452863005516	D-loop; other site
452863005517	H-loop/switch region; other site
452863005518	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
452863005519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863005520	Walker A/P-loop; other site
452863005521	ATP binding site [chemical binding]; other site
452863005522	Q-loop/lid; other site
452863005523	ABC transporter signature motif; other site
452863005524	Walker B; other site
452863005525	D-loop; other site
452863005526	H-loop/switch region; other site
452863005527	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
452863005528	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
452863005529	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
452863005530	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
452863005531	CAP-like domain; other site
452863005532	active site
452863005533	primary dimer interface [polypeptide binding]; other site
452863005534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
452863005535	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863005536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863005537	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
452863005538	CoA binding domain; Region: CoA_binding_2; pfam13380
452863005539	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
452863005540	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
452863005541	Uncharacterized conserved protein [Function unknown]; Region: COG3379
452863005542	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
452863005543	PglZ domain; Region: PglZ; pfam08665
452863005544	thymidine kinase; Provisional; Region: PRK04296
452863005545	Domain of unknown function (DUF222); Region: DUF222; pfam02720
452863005546	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863005547	active site
452863005548	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
452863005549	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
452863005550	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
452863005551	trimer interface [polypeptide binding]; other site
452863005552	active site
452863005553	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
452863005554	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
452863005555	TrkA-N domain; Region: TrkA_N; pfam02254
452863005556	TrkA-C domain; Region: TrkA_C; pfam02080
452863005557	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
452863005558	TrkA-N domain; Region: TrkA_N; pfam02254
452863005559	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
452863005560	TRAM domain; Region: TRAM; pfam01938
452863005561	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
452863005562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863005563	S-adenosylmethionine binding site [chemical binding]; other site
452863005564	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
452863005565	1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292
452863005566	TPP-binding site [chemical binding]; other site
452863005567	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
452863005568	PYR/PP interface [polypeptide binding]; other site
452863005569	dimer interface [polypeptide binding]; other site
452863005570	TPP binding site [chemical binding]; other site
452863005571	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863005572	Protein of unknown function (DUF402); Region: DUF402; pfam04167
452863005573	Protein of unknown function (DUF402); Region: DUF402; cl00979
452863005574	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863005575	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863005576	active site
452863005577	catalytic tetrad [active]
452863005578	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
452863005579	active site
452863005580	mycothione reductase; Reviewed; Region: PRK07846
452863005581	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863005582	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
452863005583	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
452863005584	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863005585	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863005586	Walker A/P-loop; other site
452863005587	ATP binding site [chemical binding]; other site
452863005588	Q-loop/lid; other site
452863005589	ABC transporter signature motif; other site
452863005590	Walker B; other site
452863005591	D-loop; other site
452863005592	H-loop/switch region; other site
452863005593	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863005594	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863005595	Walker A/P-loop; other site
452863005596	ATP binding site [chemical binding]; other site
452863005597	Q-loop/lid; other site
452863005598	ABC transporter signature motif; other site
452863005599	Walker B; other site
452863005600	D-loop; other site
452863005601	H-loop/switch region; other site
452863005602	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863005603	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
452863005604	substrate binding site [chemical binding]; other site
452863005605	oxyanion hole (OAH) forming residues; other site
452863005606	trimer interface [polypeptide binding]; other site
452863005607	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
452863005608	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
452863005609	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
452863005610	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863005611	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
452863005612	dimer interface [polypeptide binding]; other site
452863005613	active site
452863005614	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
452863005615	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
452863005616	catalytic site [active]
452863005617	putative active site [active]
452863005618	putative substrate binding site [chemical binding]; other site
452863005619	Helicase and RNase D C-terminal; Region: HRDC; smart00341
452863005620	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
452863005621	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
452863005622	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
452863005623	tetramer interface [polypeptide binding]; other site
452863005624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863005625	catalytic residue [active]
452863005626	methionine sulfoxide reductase B; Provisional; Region: PRK00222
452863005627	SelR domain; Region: SelR; pfam01641
452863005628	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863005629	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863005630	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
452863005631	putative deacylase active site [active]
452863005632	Fe-S metabolism associated domain; Region: SufE; cl00951
452863005633	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
452863005634	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
452863005635	active site residue [active]
452863005636	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
452863005637	active site residue [active]
452863005638	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
452863005639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
452863005640	benzoate transporter; Region: benE; TIGR00843
452863005641	Benzoate membrane transport protein; Region: BenE; pfam03594
452863005642	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
452863005643	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
452863005644	active site
452863005645	catalytic residues [active]
452863005646	metal binding site [ion binding]; metal-binding site
452863005647	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
452863005648	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
452863005649	putative active site [active]
452863005650	substrate binding site [chemical binding]; other site
452863005651	putative cosubstrate binding site; other site
452863005652	catalytic site [active]
452863005653	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
452863005654	substrate binding site [chemical binding]; other site
452863005655	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
452863005656	putative RNA binding site [nucleotide binding]; other site
452863005657	16S rRNA methyltransferase B; Provisional; Region: PRK14902
452863005658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863005659	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
452863005660	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
452863005661	substrate binding site [chemical binding]; other site
452863005662	hexamer interface [polypeptide binding]; other site
452863005663	metal binding site [ion binding]; metal-binding site
452863005664	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
452863005665	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
452863005666	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
452863005667	catalytic motif [active]
452863005668	Zn binding site [ion binding]; other site
452863005669	RibD C-terminal domain; Region: RibD_C; cl17279
452863005670	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
452863005671	Lumazine binding domain; Region: Lum_binding; pfam00677
452863005672	Lumazine binding domain; Region: Lum_binding; pfam00677
452863005673	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
452863005674	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
452863005675	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
452863005676	dimerization interface [polypeptide binding]; other site
452863005677	active site
452863005678	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
452863005679	homopentamer interface [polypeptide binding]; other site
452863005680	active site
452863005681	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
452863005682	metal binding site [ion binding]; metal-binding site
452863005683	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
452863005684	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
452863005685	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
452863005686	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
452863005687	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
452863005688	substrate binding site [chemical binding]; other site
452863005689	glutamase interaction surface [polypeptide binding]; other site
452863005690	TIGR03085 family protein; Region: TIGR03085
452863005691	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
452863005692	anthranilate synthase component I; Provisional; Region: PRK13571
452863005693	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
452863005694	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
452863005695	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
452863005696	active site
452863005697	ribulose/triose binding site [chemical binding]; other site
452863005698	phosphate binding site [ion binding]; other site
452863005699	substrate (anthranilate) binding pocket [chemical binding]; other site
452863005700	product (indole) binding pocket [chemical binding]; other site
452863005701	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
452863005702	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
452863005703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863005704	catalytic residue [active]
452863005705	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
452863005706	substrate binding site [chemical binding]; other site
452863005707	active site
452863005708	catalytic residues [active]
452863005709	heterodimer interface [polypeptide binding]; other site
452863005710	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
452863005711	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
452863005712	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
452863005713	active site
452863005714	dimer interface [polypeptide binding]; other site
452863005715	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
452863005716	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
452863005717	active site
452863005718	FMN binding site [chemical binding]; other site
452863005719	substrate binding site [chemical binding]; other site
452863005720	3Fe-4S cluster binding site [ion binding]; other site
452863005721	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
452863005722	domain interface; other site
452863005723	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
452863005724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863005725	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
452863005726	pyruvate kinase; Provisional; Region: PRK06247
452863005727	domain interfaces; other site
452863005728	active site
452863005729	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
452863005730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863005731	active site
452863005732	phosphorylation site [posttranslational modification]
452863005733	intermolecular recognition site; other site
452863005734	dimerization interface [polypeptide binding]; other site
452863005735	ANTAR domain; Region: ANTAR; pfam03861
452863005736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863005737	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863005738	NAD(P) binding site [chemical binding]; other site
452863005739	active site
452863005740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
452863005741	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
452863005742	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
452863005743	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863005744	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863005745	DNA binding residues [nucleotide binding]
452863005746	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
452863005747	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
452863005748	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
452863005749	putative dimer interface [polypeptide binding]; other site
452863005750	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
452863005751	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863005752	GAF domain; Region: GAF_2; pfam13185
452863005753	GAF domain; Region: GAF; cl17456
452863005754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
452863005755	Histidine kinase; Region: HisKA_3; pfam07730
452863005756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863005757	ATP binding site [chemical binding]; other site
452863005758	Mg2+ binding site [ion binding]; other site
452863005759	G-X-G motif; other site
452863005760	transcriptional regulator NarP; Provisional; Region: PRK10403
452863005761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863005762	active site
452863005763	phosphorylation site [posttranslational modification]
452863005764	intermolecular recognition site; other site
452863005765	dimerization interface [polypeptide binding]; other site
452863005766	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
452863005767	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
452863005768	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
452863005769	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
452863005770	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
452863005771	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
452863005772	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
452863005773	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
452863005774	Ligand Binding Site [chemical binding]; other site
452863005775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863005776	dimer interface [polypeptide binding]; other site
452863005777	phosphorylation site [posttranslational modification]
452863005778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863005779	ATP binding site [chemical binding]; other site
452863005780	Mg2+ binding site [ion binding]; other site
452863005781	G-X-G motif; other site
452863005782	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
452863005783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863005784	active site
452863005785	phosphorylation site [posttranslational modification]
452863005786	intermolecular recognition site; other site
452863005787	dimerization interface [polypeptide binding]; other site
452863005788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863005789	DNA binding site [nucleotide binding]
452863005790	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
452863005791	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
452863005792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863005793	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863005794	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863005795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863005796	dimer interface [polypeptide binding]; other site
452863005797	conserved gate region; other site
452863005798	putative PBP binding loops; other site
452863005799	ABC-ATPase subunit interface; other site
452863005800	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863005801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863005802	dimer interface [polypeptide binding]; other site
452863005803	conserved gate region; other site
452863005804	putative PBP binding loops; other site
452863005805	ABC-ATPase subunit interface; other site
452863005806	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
452863005807	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
452863005808	inhibitor binding site; inhibition site
452863005809	catalytic Zn binding site [ion binding]; other site
452863005810	structural Zn binding site [ion binding]; other site
452863005811	NADP binding site [chemical binding]; other site
452863005812	tetramer interface [polypeptide binding]; other site
452863005813	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
452863005814	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863005815	putative substrate binding site [chemical binding]; other site
452863005816	putative ATP binding site [chemical binding]; other site
452863005817	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
452863005818	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
452863005819	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
452863005820	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
452863005821	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
452863005822	ligand binding site [chemical binding]; other site
452863005823	homodimer interface [polypeptide binding]; other site
452863005824	NAD(P) binding site [chemical binding]; other site
452863005825	trimer interface B [polypeptide binding]; other site
452863005826	trimer interface A [polypeptide binding]; other site
452863005827	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
452863005828	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
452863005829	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
452863005830	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
452863005831	aromatic arch; other site
452863005832	DCoH dimer interaction site [polypeptide binding]; other site
452863005833	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
452863005834	DCoH tetramer interaction site [polypeptide binding]; other site
452863005835	substrate binding site [chemical binding]; other site
452863005836	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
452863005837	methionine synthase; Provisional; Region: PRK01207
452863005838	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
452863005839	substrate binding site [chemical binding]; other site
452863005840	THF binding site; other site
452863005841	zinc-binding site [ion binding]; other site
452863005842	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
452863005843	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
452863005844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863005845	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863005846	dimerization interface [polypeptide binding]; other site
452863005847	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
452863005848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863005849	NmrA-like family; Region: NmrA; pfam05368
452863005850	NAD(P) binding site [chemical binding]; other site
452863005851	active site
452863005852	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
452863005853	hydroperoxidase II; Provisional; Region: katE; PRK11249
452863005854	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
452863005855	heme binding pocket [chemical binding]; other site
452863005856	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
452863005857	domain interactions; other site
452863005858	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
452863005859	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
452863005860	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
452863005861	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
452863005862	NAD(P) binding site [chemical binding]; other site
452863005863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
452863005864	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
452863005865	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
452863005866	dimer interface [polypeptide binding]; other site
452863005867	catalytic residue [active]
452863005868	metal binding site [ion binding]; metal-binding site
452863005869	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
452863005870	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863005871	DNA-binding site [nucleotide binding]; DNA binding site
452863005872	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
452863005873	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
452863005874	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
452863005875	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
452863005876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863005877	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
452863005878	Walker A/P-loop; other site
452863005879	ATP binding site [chemical binding]; other site
452863005880	Q-loop/lid; other site
452863005881	ABC transporter signature motif; other site
452863005882	Walker B; other site
452863005883	D-loop; other site
452863005884	H-loop/switch region; other site
452863005885	MbtH-like protein; Region: MbtH; pfam03621
452863005886	Condensation domain; Region: Condensation; pfam00668
452863005887	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
452863005888	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
452863005889	acyl-activating enzyme (AAE) consensus motif; other site
452863005890	AMP binding site [chemical binding]; other site
452863005891	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
452863005892	Condensation domain; Region: Condensation; pfam00668
452863005893	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
452863005894	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
452863005895	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
452863005896	acyl-activating enzyme (AAE) consensus motif; other site
452863005897	AMP binding site [chemical binding]; other site
452863005898	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
452863005899	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
452863005900	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
452863005901	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
452863005902	acyl-activating enzyme (AAE) consensus motif; other site
452863005903	AMP binding site [chemical binding]; other site
452863005904	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
452863005905	Melibiase; Region: Melibiase; pfam02065
452863005906	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863005907	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863005908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863005909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863005910	dimer interface [polypeptide binding]; other site
452863005911	conserved gate region; other site
452863005912	putative PBP binding loops; other site
452863005913	ABC-ATPase subunit interface; other site
452863005914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
452863005915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863005916	ABC-ATPase subunit interface; other site
452863005917	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863005918	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863005919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863005920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863005921	DNA binding site [nucleotide binding]
452863005922	domain linker motif; other site
452863005923	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863005924	dimerization interface [polypeptide binding]; other site
452863005925	ligand binding site [chemical binding]; other site
452863005926	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863005927	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863005928	active site
452863005929	catalytic tetrad [active]
452863005930	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863005931	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863005932	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
452863005933	N-acetyl-D-glucosamine binding site [chemical binding]; other site
452863005934	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863005935	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
452863005936	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
452863005937	FAD binding domain; Region: FAD_binding_4; pfam01565
452863005938	Berberine and berberine like; Region: BBE; pfam08031
452863005939	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
452863005940	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
452863005941	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
452863005942	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863005943	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863005944	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863005945	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
452863005946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863005947	NAD(P) binding site [chemical binding]; other site
452863005948	active site
452863005949	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
452863005950	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
452863005951	NAD binding site [chemical binding]; other site
452863005952	substrate binding site [chemical binding]; other site
452863005953	catalytic Zn binding site [ion binding]; other site
452863005954	structural Zn binding site [ion binding]; other site
452863005955	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
452863005956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863005957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
452863005958	Walker A/P-loop; other site
452863005959	ATP binding site [chemical binding]; other site
452863005960	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
452863005961	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
452863005962	metal ion-dependent adhesion site (MIDAS); other site
452863005963	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
452863005964	RibD C-terminal domain; Region: RibD_C; cl17279
452863005965	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
452863005966	dimerization interface [polypeptide binding]; other site
452863005967	active site
452863005968	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863005969	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
452863005970	active site
452863005971	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
452863005972	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
452863005973	active site
452863005974	metal binding site 1 [ion binding]; metal-binding site
452863005975	putative 5' ssDNA interaction site; other site
452863005976	metal binding site 3; metal-binding site
452863005977	metal binding site 2 [ion binding]; metal-binding site
452863005978	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
452863005979	putative DNA binding site [nucleotide binding]; other site
452863005980	putative metal binding site [ion binding]; other site
452863005981	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
452863005982	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863005983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863005984	homodimer interface [polypeptide binding]; other site
452863005985	catalytic residue [active]
452863005986	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
452863005987	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863005988	Walker A/P-loop; other site
452863005989	ATP binding site [chemical binding]; other site
452863005990	Q-loop/lid; other site
452863005991	ABC transporter signature motif; other site
452863005992	Walker B; other site
452863005993	D-loop; other site
452863005994	H-loop/switch region; other site
452863005995	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863005996	Walker A/P-loop; other site
452863005997	ATP binding site [chemical binding]; other site
452863005998	Q-loop/lid; other site
452863005999	ABC transporter signature motif; other site
452863006000	Walker B; other site
452863006001	D-loop; other site
452863006002	H-loop/switch region; other site
452863006003	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
452863006004	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863006005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863006006	dimer interface [polypeptide binding]; other site
452863006007	conserved gate region; other site
452863006008	putative PBP binding loops; other site
452863006009	ABC-ATPase subunit interface; other site
452863006010	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863006011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863006012	dimer interface [polypeptide binding]; other site
452863006013	conserved gate region; other site
452863006014	putative PBP binding loops; other site
452863006015	ABC-ATPase subunit interface; other site
452863006016	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863006017	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
452863006018	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
452863006019	FAD binding domain; Region: FAD_binding_4; pfam01565
452863006020	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
452863006021	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
452863006022	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863006023	putative Mg++ binding site [ion binding]; other site
452863006024	nucleotide binding region [chemical binding]; other site
452863006025	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
452863006026	Helicase associated domain (HA2); Region: HA2; pfam04408
452863006027	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
452863006028	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863006029	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
452863006030	nucleotide binding site [chemical binding]; other site
452863006031	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
452863006032	Integral membrane protein TerC family; Region: TerC; cl10468
452863006033	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
452863006034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863006035	active site
452863006036	phosphorylation site [posttranslational modification]
452863006037	intermolecular recognition site; other site
452863006038	dimerization interface [polypeptide binding]; other site
452863006039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863006040	DNA binding site [nucleotide binding]
452863006041	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863006042	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
452863006043	dimer interface [polypeptide binding]; other site
452863006044	Methyltransferase domain; Region: Methyltransf_31; pfam13847
452863006045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863006046	S-adenosylmethionine binding site [chemical binding]; other site
452863006047	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863006048	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863006049	DNA binding residues [nucleotide binding]
452863006050	dimerization interface [polypeptide binding]; other site
452863006051	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
452863006052	RibD C-terminal domain; Region: RibD_C; cl17279
452863006053	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
452863006054	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
452863006055	CoenzymeA binding site [chemical binding]; other site
452863006056	subunit interaction site [polypeptide binding]; other site
452863006057	PHB binding site; other site
452863006058	DNA polymerase I; Provisional; Region: PRK05755
452863006059	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
452863006060	active site
452863006061	metal binding site 1 [ion binding]; metal-binding site
452863006062	putative 5' ssDNA interaction site; other site
452863006063	metal binding site 3; metal-binding site
452863006064	metal binding site 2 [ion binding]; metal-binding site
452863006065	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
452863006066	putative DNA binding site [nucleotide binding]; other site
452863006067	putative metal binding site [ion binding]; other site
452863006068	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
452863006069	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
452863006070	active site
452863006071	DNA binding site [nucleotide binding]
452863006072	catalytic site [active]
452863006073	hypothetical protein; Provisional; Region: PRK01346
452863006074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863006075	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
452863006076	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
452863006077	RNA binding site [nucleotide binding]; other site
452863006078	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
452863006079	RNA binding site [nucleotide binding]; other site
452863006080	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
452863006081	RNA binding site [nucleotide binding]; other site
452863006082	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
452863006083	RNA binding site [nucleotide binding]; other site
452863006084	domain interface; other site
452863006085	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863006086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863006087	Coenzyme A binding pocket [chemical binding]; other site
452863006088	Uncharacterized conserved protein [Function unknown]; Region: COG1739
452863006089	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
452863006090	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
452863006091	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863006092	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
452863006093	Walker A/P-loop; other site
452863006094	ATP binding site [chemical binding]; other site
452863006095	Q-loop/lid; other site
452863006096	ABC transporter signature motif; other site
452863006097	Walker B; other site
452863006098	D-loop; other site
452863006099	H-loop/switch region; other site
452863006100	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
452863006101	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
452863006102	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
452863006103	CoA-binding site [chemical binding]; other site
452863006104	ATP-binding [chemical binding]; other site
452863006105	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
452863006106	excinuclease ABC subunit B; Provisional; Region: PRK05298
452863006107	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863006108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863006109	nucleotide binding region [chemical binding]; other site
452863006110	ATP-binding site [chemical binding]; other site
452863006111	Ultra-violet resistance protein B; Region: UvrB; pfam12344
452863006112	UvrB/uvrC motif; Region: UVR; pfam02151
452863006113	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
452863006114	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
452863006115	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
452863006116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863006117	Coenzyme A binding pocket [chemical binding]; other site
452863006118	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863006119	ATP binding site [chemical binding]; other site
452863006120	putative Mg++ binding site [ion binding]; other site
452863006121	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863006122	nucleotide binding region [chemical binding]; other site
452863006123	ATP-binding site [chemical binding]; other site
452863006124	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
452863006125	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
452863006126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863006127	S-adenosylmethionine binding site [chemical binding]; other site
452863006128	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863006129	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
452863006130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863006131	Walker A/P-loop; other site
452863006132	ATP binding site [chemical binding]; other site
452863006133	Q-loop/lid; other site
452863006134	ABC transporter signature motif; other site
452863006135	Walker B; other site
452863006136	D-loop; other site
452863006137	H-loop/switch region; other site
452863006138	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863006139	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863006140	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
452863006141	Walker A/P-loop; other site
452863006142	ATP binding site [chemical binding]; other site
452863006143	Q-loop/lid; other site
452863006144	ABC transporter signature motif; other site
452863006145	Walker B; other site
452863006146	D-loop; other site
452863006147	H-loop/switch region; other site
452863006148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863006149	DNA-binding site [nucleotide binding]; DNA binding site
452863006150	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
452863006151	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
452863006152	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
452863006153	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
452863006154	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
452863006155	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863006156	active site
452863006157	motif I; other site
452863006158	motif II; other site
452863006159	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
452863006160	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
452863006161	putative acyl-acceptor binding pocket; other site
452863006162	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
452863006163	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
452863006164	GIY-YIG motif/motif A; other site
452863006165	active site
452863006166	catalytic site [active]
452863006167	putative DNA binding site [nucleotide binding]; other site
452863006168	metal binding site [ion binding]; metal-binding site
452863006169	UvrB/uvrC motif; Region: UVR; pfam02151
452863006170	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
452863006171	Helix-hairpin-helix motif; Region: HHH; pfam00633
452863006172	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
452863006173	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
452863006174	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
452863006175	putative substrate binding pocket [chemical binding]; other site
452863006176	dimer interface [polypeptide binding]; other site
452863006177	phosphate binding site [ion binding]; other site
452863006178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
452863006179	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
452863006180	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
452863006181	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
452863006182	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
452863006183	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
452863006184	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
452863006185	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
452863006186	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
452863006187	Phosphoglycerate kinase; Region: PGK; pfam00162
452863006188	substrate binding site [chemical binding]; other site
452863006189	hinge regions; other site
452863006190	ADP binding site [chemical binding]; other site
452863006191	catalytic site [active]
452863006192	triosephosphate isomerase; Provisional; Region: PRK14567
452863006193	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
452863006194	substrate binding site [chemical binding]; other site
452863006195	dimer interface [polypeptide binding]; other site
452863006196	catalytic triad [active]
452863006197	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
452863006198	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
452863006199	putative active site [active]
452863006200	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
452863006201	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
452863006202	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
452863006203	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
452863006204	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
452863006205	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
452863006206	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
452863006207	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
452863006208	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
452863006209	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
452863006210	putative active site [active]
452863006211	transaldolase; Provisional; Region: PRK03903
452863006212	catalytic residue [active]
452863006213	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
452863006214	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
452863006215	TPP-binding site [chemical binding]; other site
452863006216	dimer interface [polypeptide binding]; other site
452863006217	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
452863006218	PYR/PP interface [polypeptide binding]; other site
452863006219	dimer interface [polypeptide binding]; other site
452863006220	TPP binding site [chemical binding]; other site
452863006221	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863006222	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
452863006223	UbiA prenyltransferase family; Region: UbiA; pfam01040
452863006224	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
452863006225	Sulfate transporter family; Region: Sulfate_transp; pfam00916
452863006226	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
452863006227	active site clefts [active]
452863006228	zinc binding site [ion binding]; other site
452863006229	dimer interface [polypeptide binding]; other site
452863006230	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
452863006231	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
452863006232	ABC-2 type transporter; Region: ABC2_membrane; cl17235
452863006233	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
452863006234	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
452863006235	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863006236	Walker A/P-loop; other site
452863006237	ATP binding site [chemical binding]; other site
452863006238	Q-loop/lid; other site
452863006239	ABC transporter signature motif; other site
452863006240	Walker B; other site
452863006241	D-loop; other site
452863006242	H-loop/switch region; other site
452863006243	Predicted transcriptional regulator [Transcription]; Region: COG2345
452863006244	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863006245	putative DNA binding site [nucleotide binding]; other site
452863006246	putative Zn2+ binding site [ion binding]; other site
452863006247	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
452863006248	FeS assembly protein SufB; Region: sufB; TIGR01980
452863006249	FeS assembly protein SufD; Region: sufD; TIGR01981
452863006250	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
452863006251	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
452863006252	[2Fe-2S] cluster binding site [ion binding]; other site
452863006253	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
452863006254	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
452863006255	Walker A/P-loop; other site
452863006256	ATP binding site [chemical binding]; other site
452863006257	Q-loop/lid; other site
452863006258	ABC transporter signature motif; other site
452863006259	Walker B; other site
452863006260	D-loop; other site
452863006261	H-loop/switch region; other site
452863006262	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
452863006263	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
452863006264	acyl-CoA synthetase; Validated; Region: PRK07638
452863006265	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863006266	AMP binding site [chemical binding]; other site
452863006267	active site
452863006268	acyl-activating enzyme (AAE) consensus motif; other site
452863006269	CoA binding site [chemical binding]; other site
452863006270	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863006271	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
452863006272	dimer interface [polypeptide binding]; other site
452863006273	active site
452863006274	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
452863006275	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863006276	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863006277	Walker A/P-loop; other site
452863006278	ATP binding site [chemical binding]; other site
452863006279	Q-loop/lid; other site
452863006280	ABC transporter signature motif; other site
452863006281	Walker B; other site
452863006282	D-loop; other site
452863006283	H-loop/switch region; other site
452863006284	BioY family; Region: BioY; pfam02632
452863006285	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
452863006286	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
452863006287	tetramer interface [polypeptide binding]; other site
452863006288	active site
452863006289	Mg2+/Mn2+ binding site [ion binding]; other site
452863006290	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
452863006291	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
452863006292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863006293	Walker A/P-loop; other site
452863006294	ATP binding site [chemical binding]; other site
452863006295	Q-loop/lid; other site
452863006296	ABC transporter signature motif; other site
452863006297	Walker B; other site
452863006298	D-loop; other site
452863006299	H-loop/switch region; other site
452863006300	ABC transporter; Region: ABC_tran_2; pfam12848
452863006301	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863006302	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
452863006303	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863006304	DNA binding residues [nucleotide binding]
452863006305	dimer interface [polypeptide binding]; other site
452863006306	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
452863006307	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863006308	HTH domain; Region: HTH_11; pfam08279
452863006309	WYL domain; Region: WYL; pfam13280
452863006310	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
452863006311	putative deacylase active site [active]
452863006312	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
452863006313	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
452863006314	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
452863006315	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
452863006316	NAD(P) binding site [chemical binding]; other site
452863006317	homotetramer interface [polypeptide binding]; other site
452863006318	homodimer interface [polypeptide binding]; other site
452863006319	active site
452863006320	short chain dehydrogenase; Provisional; Region: PRK07806
452863006321	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
452863006322	NAD(P) binding site [chemical binding]; other site
452863006323	active site
452863006324	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
452863006325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863006326	motif II; other site
452863006327	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
452863006328	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863006329	Walker A/P-loop; other site
452863006330	ATP binding site [chemical binding]; other site
452863006331	Q-loop/lid; other site
452863006332	ABC transporter signature motif; other site
452863006333	Walker B; other site
452863006334	D-loop; other site
452863006335	H-loop/switch region; other site
452863006336	hypothetical protein; Provisional; Region: PRK10621
452863006337	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
452863006338	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
452863006339	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
452863006340	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
452863006341	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
452863006342	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
452863006343	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
452863006344	Zn binding site [ion binding]; other site
452863006345	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
452863006346	Uncharacterized conserved protein [Function unknown]; Region: COG2308
452863006347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
452863006348	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
452863006349	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
452863006350	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
452863006351	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
452863006352	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863006353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863006354	NAD(P) binding site [chemical binding]; other site
452863006355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863006356	NAD(P) binding site [chemical binding]; other site
452863006357	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
452863006358	active site
452863006359	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
452863006360	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
452863006361	ligand binding site; other site
452863006362	oligomer interface; other site
452863006363	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
452863006364	sulfate 1 binding site; other site
452863006365	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
452863006366	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
452863006367	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863006368	acyl-coenzyme A oxidase; Region: PLN02636
452863006369	active site
452863006370	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863006371	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863006372	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
452863006373	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863006374	dimer interface [polypeptide binding]; other site
452863006375	active site
452863006376	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
452863006377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863006378	NAD(P) binding site [chemical binding]; other site
452863006379	active site
452863006380	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
452863006381	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
452863006382	active site 2 [active]
452863006383	active site 1 [active]
452863006384	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
452863006385	Beta-lactamase; Region: Beta-lactamase; pfam00144
452863006386	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
452863006387	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
452863006388	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
452863006389	putative dimer interface [polypeptide binding]; other site
452863006390	N-terminal domain interface [polypeptide binding]; other site
452863006391	putative substrate binding pocket (H-site) [chemical binding]; other site
452863006392	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
452863006393	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
452863006394	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
452863006395	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
452863006396	putative active site [active]
452863006397	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
452863006398	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
452863006399	putative active site [active]
452863006400	Protein of unknown function (DUF805); Region: DUF805; pfam05656
452863006401	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863006402	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
452863006403	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
452863006404	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863006405	ABC transporter signature motif; other site
452863006406	Walker B; other site
452863006407	D-loop; other site
452863006408	H-loop/switch region; other site
452863006409	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
452863006410	hypothetical protein; Provisional; Region: PRK07906
452863006411	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
452863006412	putative metal binding site [ion binding]; other site
452863006413	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
452863006414	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
452863006415	active site
452863006416	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863006417	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863006418	active site
452863006419	catalytic tetrad [active]
452863006420	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
452863006421	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863006422	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
452863006423	active site
452863006424	HIGH motif; other site
452863006425	nucleotide binding site [chemical binding]; other site
452863006426	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863006427	active site
452863006428	KMSKS motif; other site
452863006429	PAC2 family; Region: PAC2; pfam09754
452863006430	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
452863006431	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
452863006432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863006433	motif II; other site
452863006434	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
452863006435	Peptidase family M50; Region: Peptidase_M50; pfam02163
452863006436	active site
452863006437	putative substrate binding region [chemical binding]; other site
452863006438	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
452863006439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863006440	S-adenosylmethionine binding site [chemical binding]; other site
452863006441	proteasome ATPase; Region: pup_AAA; TIGR03689
452863006442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863006443	Walker A motif; other site
452863006444	ATP binding site [chemical binding]; other site
452863006445	Walker B motif; other site
452863006446	arginine finger; other site
452863006447	Pup-ligase protein; Region: Pup_ligase; pfam03136
452863006448	Pup-like protein; Region: Pup; pfam05639
452863006449	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
452863006450	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
452863006451	active site
452863006452	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
452863006453	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
452863006454	active site
452863006455	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
452863006456	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
452863006457	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
452863006458	WYL domain; Region: WYL; pfam13280
452863006459	Predicted transcriptional regulator [Transcription]; Region: COG2378
452863006460	WYL domain; Region: WYL; pfam13280
452863006461	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
452863006462	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
452863006463	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
452863006464	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
452863006465	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863006466	ATP binding site [chemical binding]; other site
452863006467	putative Mg++ binding site [ion binding]; other site
452863006468	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863006469	nucleotide binding region [chemical binding]; other site
452863006470	ATP-binding site [chemical binding]; other site
452863006471	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
452863006472	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
452863006473	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863006474	active site
452863006475	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
452863006476	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
452863006477	Ligand binding site; other site
452863006478	Putative Catalytic site; other site
452863006479	DXD motif; other site
452863006480	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
452863006481	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
452863006482	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
452863006483	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
452863006484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863006485	S-adenosylmethionine binding site [chemical binding]; other site
452863006486	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
452863006487	active site
452863006488	catalytic residues [active]
452863006489	metal binding site [ion binding]; metal-binding site
452863006490	SnoaL-like domain; Region: SnoaL_2; pfam12680
452863006491	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863006492	FAD binding domain; Region: FAD_binding_3; pfam01494
452863006493	hypothetical protein; Provisional; Region: PRK06202
452863006494	S-adenosylmethionine binding site [chemical binding]; other site
452863006495	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
452863006496	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
452863006497	malonyl-CoA binding site [chemical binding]; other site
452863006498	dimer interface [polypeptide binding]; other site
452863006499	active site
452863006500	product binding site; other site
452863006501	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
452863006502	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863006503	AsnC family; Region: AsnC_trans_reg; pfam01037
452863006504	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
452863006505	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
452863006506	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
452863006507	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
452863006508	Subunit I/III interface [polypeptide binding]; other site
452863006509	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
452863006510	Cytochrome c; Region: Cytochrom_C; pfam00034
452863006511	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
452863006512	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
452863006513	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
452863006514	iron-sulfur cluster [ion binding]; other site
452863006515	[2Fe-2S] cluster binding site [ion binding]; other site
452863006516	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
452863006517	intrachain domain interface; other site
452863006518	interchain domain interface [polypeptide binding]; other site
452863006519	heme bL binding site [chemical binding]; other site
452863006520	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
452863006521	heme bH binding site [chemical binding]; other site
452863006522	Qo binding site; other site
452863006523	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
452863006524	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863006525	DNA-binding site [nucleotide binding]; DNA binding site
452863006526	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
452863006527	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
452863006528	dimerization domain swap beta strand [polypeptide binding]; other site
452863006529	regulatory protein interface [polypeptide binding]; other site
452863006530	active site
452863006531	regulatory phosphorylation site [posttranslational modification]; other site
452863006532	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
452863006533	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
452863006534	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
452863006535	D-pathway; other site
452863006536	Putative ubiquinol binding site [chemical binding]; other site
452863006537	Low-spin heme (heme b) binding site [chemical binding]; other site
452863006538	Putative water exit pathway; other site
452863006539	Binuclear center (heme o3/CuB) [ion binding]; other site
452863006540	K-pathway; other site
452863006541	Putative proton exit pathway; other site
452863006542	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
452863006543	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
452863006544	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
452863006545	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
452863006546	hypothetical protein; Provisional; Region: PRK07907
452863006547	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
452863006548	active site
452863006549	metal binding site [ion binding]; metal-binding site
452863006550	dimer interface [polypeptide binding]; other site
452863006551	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
452863006552	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
452863006553	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
452863006554	quinone interaction residues [chemical binding]; other site
452863006555	active site
452863006556	catalytic residues [active]
452863006557	FMN binding site [chemical binding]; other site
452863006558	substrate binding site [chemical binding]; other site
452863006559	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
452863006560	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
452863006561	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863006562	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
452863006563	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
452863006564	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
452863006565	catalytic residue [active]
452863006566	putative FPP diphosphate  binding site; other site
452863006567	putative FPP binding hydrophobic cleft; other site
452863006568	dimer interface [polypeptide binding]; other site
452863006569	putative IPP diphosphate binding site; other site
452863006570	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
452863006571	Recombination protein O N terminal; Region: RecO_N; pfam11967
452863006572	Recombination protein O C terminal; Region: RecO_C; pfam02565
452863006573	2-isopropylmalate synthase; Validated; Region: PRK03739
452863006574	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
452863006575	active site
452863006576	catalytic residues [active]
452863006577	metal binding site [ion binding]; metal-binding site
452863006578	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
452863006579	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
452863006580	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
452863006581	active site
452863006582	Zn binding site [ion binding]; other site
452863006583	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
452863006584	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
452863006585	GTPase Era; Reviewed; Region: era; PRK00089
452863006586	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
452863006587	G1 box; other site
452863006588	GTP/Mg2+ binding site [chemical binding]; other site
452863006589	Switch I region; other site
452863006590	G2 box; other site
452863006591	Switch II region; other site
452863006592	G3 box; other site
452863006593	G4 box; other site
452863006594	G5 box; other site
452863006595	KH domain; Region: KH_2; pfam07650
452863006596	Domain of unknown function DUF21; Region: DUF21; pfam01595
452863006597	FOG: CBS domain [General function prediction only]; Region: COG0517
452863006598	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
452863006599	Transporter associated domain; Region: CorC_HlyC; smart01091
452863006600	metal-binding heat shock protein; Provisional; Region: PRK00016
452863006601	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
452863006602	PhoH-like protein; Region: PhoH; pfam02562
452863006603	Sporulation and spore germination; Region: Germane; pfam10646
452863006604	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
452863006605	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
452863006606	RNA methyltransferase, RsmE family; Region: TIGR00046
452863006607	chaperone protein DnaJ; Provisional; Region: PRK14278
452863006608	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
452863006609	HSP70 interaction site [polypeptide binding]; other site
452863006610	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
452863006611	Zn binding sites [ion binding]; other site
452863006612	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
452863006613	dimer interface [polypeptide binding]; other site
452863006614	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
452863006615	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
452863006616	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
452863006617	Tic20-like protein; Region: Tic20; pfam09685
452863006618	coproporphyrinogen III oxidase; Validated; Region: PRK05628
452863006619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
452863006620	FeS/SAM binding site; other site
452863006621	GTP-binding protein LepA; Provisional; Region: PRK05433
452863006622	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
452863006623	G1 box; other site
452863006624	putative GEF interaction site [polypeptide binding]; other site
452863006625	GTP/Mg2+ binding site [chemical binding]; other site
452863006626	Switch I region; other site
452863006627	G2 box; other site
452863006628	G3 box; other site
452863006629	Switch II region; other site
452863006630	G4 box; other site
452863006631	G5 box; other site
452863006632	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
452863006633	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
452863006634	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
452863006635	PemK-like protein; Region: PemK; pfam02452
452863006636	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
452863006637	hypothetical protein; Reviewed; Region: PRK07914
452863006638	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
452863006639	Competence protein; Region: Competence; cl00471
452863006640	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
452863006641	EDD domain protein, DegV family; Region: DegV; TIGR00762
452863006642	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
452863006643	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
452863006644	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
452863006645	HIGH motif; other site
452863006646	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
452863006647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863006648	active site
452863006649	KMSKS motif; other site
452863006650	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
452863006651	tRNA binding surface [nucleotide binding]; other site
452863006652	glycerol kinase; Provisional; Region: glpK; PRK00047
452863006653	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
452863006654	N- and C-terminal domain interface [polypeptide binding]; other site
452863006655	active site
452863006656	MgATP binding site [chemical binding]; other site
452863006657	catalytic site [active]
452863006658	metal binding site [ion binding]; metal-binding site
452863006659	putative homotetramer interface [polypeptide binding]; other site
452863006660	glycerol binding site [chemical binding]; other site
452863006661	homodimer interface [polypeptide binding]; other site
452863006662	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
452863006663	amphipathic channel; other site
452863006664	Asn-Pro-Ala signature motifs; other site
452863006665	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
452863006666	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
452863006667	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
452863006668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863006669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863006670	active site
452863006671	catalytic tetrad [active]
452863006672	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863006673	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
452863006674	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863006675	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
452863006676	primosome assembly protein PriA; Provisional; Region: PRK14873
452863006677	S-adenosylmethionine synthetase; Validated; Region: PRK05250
452863006678	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
452863006679	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
452863006680	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
452863006681	Flavoprotein; Region: Flavoprotein; pfam02441
452863006682	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
452863006683	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
452863006684	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
452863006685	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
452863006686	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
452863006687	catalytic site [active]
452863006688	G-X2-G-X-G-K; other site
452863006689	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
452863006690	active site
452863006691	dimer interface [polypeptide binding]; other site
452863006692	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
452863006693	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
452863006694	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
452863006695	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
452863006696	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
452863006697	ATP-grasp domain; Region: ATP-grasp_4; cl17255
452863006698	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
452863006699	IMP binding site; other site
452863006700	dimer interface [polypeptide binding]; other site
452863006701	interdomain contacts; other site
452863006702	partial ornithine binding site; other site
452863006703	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
452863006704	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
452863006705	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
452863006706	catalytic site [active]
452863006707	subunit interface [polypeptide binding]; other site
452863006708	dihydroorotase; Validated; Region: pyrC; PRK09357
452863006709	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863006710	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
452863006711	active site
452863006712	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
452863006713	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
452863006714	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
452863006715	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
452863006716	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863006717	active site
452863006718	Protease prsW family; Region: PrsW-protease; pfam13367
452863006719	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
452863006720	putative RNA binding site [nucleotide binding]; other site
452863006721	elongation factor P; Validated; Region: PRK00529
452863006722	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
452863006723	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
452863006724	RNA binding site [nucleotide binding]; other site
452863006725	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
452863006726	RNA binding site [nucleotide binding]; other site
452863006727	Tetratricopeptide repeat; Region: TPR_12; pfam13424
452863006728	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
452863006729	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
452863006730	active site
452863006731	dimer interface [polypeptide binding]; other site
452863006732	metal binding site [ion binding]; metal-binding site
452863006733	shikimate kinase; Reviewed; Region: aroK; PRK00131
452863006734	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
452863006735	ADP binding site [chemical binding]; other site
452863006736	magnesium binding site [ion binding]; other site
452863006737	putative shikimate binding site; other site
452863006738	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
452863006739	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
452863006740	Tetramer interface [polypeptide binding]; other site
452863006741	active site
452863006742	FMN-binding site [chemical binding]; other site
452863006743	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
452863006744	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
452863006745	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
452863006746	shikimate binding site; other site
452863006747	NAD(P) binding site [chemical binding]; other site
452863006748	YceG-like family; Region: YceG; pfam02618
452863006749	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
452863006750	dimerization interface [polypeptide binding]; other site
452863006751	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
452863006752	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
452863006753	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
452863006754	motif 1; other site
452863006755	active site
452863006756	motif 2; other site
452863006757	motif 3; other site
452863006758	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
452863006759	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
452863006760	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
452863006761	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863006762	RNA binding surface [nucleotide binding]; other site
452863006763	recombination factor protein RarA; Reviewed; Region: PRK13342
452863006764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863006765	Walker A motif; other site
452863006766	ATP binding site [chemical binding]; other site
452863006767	Walker B motif; other site
452863006768	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
452863006769	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
452863006770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863006771	Coenzyme A binding pocket [chemical binding]; other site
452863006772	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
452863006773	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
452863006774	dimer interface [polypeptide binding]; other site
452863006775	anticodon binding site; other site
452863006776	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
452863006777	homodimer interface [polypeptide binding]; other site
452863006778	motif 1; other site
452863006779	active site
452863006780	motif 2; other site
452863006781	GAD domain; Region: GAD; pfam02938
452863006782	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
452863006783	active site
452863006784	motif 3; other site
452863006785	histidyl-tRNA synthetase; Region: hisS; TIGR00442
452863006786	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
452863006787	dimer interface [polypeptide binding]; other site
452863006788	motif 1; other site
452863006789	active site
452863006790	motif 2; other site
452863006791	motif 3; other site
452863006792	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
452863006793	anticodon binding site; other site
452863006794	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
452863006795	active site
452863006796	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
452863006797	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
452863006798	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
452863006799	HD domain; Region: HD_4; pfam13328
452863006800	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
452863006801	synthetase active site [active]
452863006802	NTP binding site [chemical binding]; other site
452863006803	metal binding site [ion binding]; metal-binding site
452863006804	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
452863006805	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
452863006806	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
452863006807	Protein export membrane protein; Region: SecD_SecF; cl14618
452863006808	protein-export membrane protein SecD; Region: secD; TIGR01129
452863006809	Protein export membrane protein; Region: SecD_SecF; cl14618
452863006810	Preprotein translocase subunit; Region: YajC; pfam02699
452863006811	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
452863006812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863006813	Walker A motif; other site
452863006814	ATP binding site [chemical binding]; other site
452863006815	Walker B motif; other site
452863006816	arginine finger; other site
452863006817	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
452863006818	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
452863006819	RuvA N terminal domain; Region: RuvA_N; pfam01330
452863006820	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
452863006821	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
452863006822	active site
452863006823	putative DNA-binding cleft [nucleotide binding]; other site
452863006824	dimer interface [polypeptide binding]; other site
452863006825	hypothetical protein; Validated; Region: PRK00110
452863006826	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
452863006827	predicted active site [active]
452863006828	catalytic triad [active]
452863006829	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863006830	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
452863006831	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
452863006832	catalytic triad [active]
452863006833	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
452863006834	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
452863006835	putative active site [active]
452863006836	putative metal binding site [ion binding]; other site
452863006837	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
452863006838	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
452863006839	active site
452863006840	Zn binding site [ion binding]; other site
452863006841	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
452863006842	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
452863006843	active site
452863006844	multimer interface [polypeptide binding]; other site
452863006845	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
452863006846	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
452863006847	nucleotide binding site/active site [active]
452863006848	HIT family signature motif; other site
452863006849	catalytic residue [active]
452863006850	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
452863006851	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
452863006852	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
452863006853	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
452863006854	active site
452863006855	dimer interface [polypeptide binding]; other site
452863006856	motif 1; other site
452863006857	motif 2; other site
452863006858	motif 3; other site
452863006859	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
452863006860	anticodon binding site; other site
452863006861	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
452863006862	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
452863006863	active site
452863006864	PHP Thumb interface [polypeptide binding]; other site
452863006865	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
452863006866	generic binding surface I; other site
452863006867	Chorismate mutase type II; Region: CM_2; smart00830
452863006868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863006869	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
452863006870	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
452863006871	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
452863006872	catalytic residues [active]
452863006873	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
452863006874	ABC1 family; Region: ABC1; cl17513
452863006875	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
452863006876	Predicted transcriptional regulators [Transcription]; Region: COG1695
452863006877	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
452863006878	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
452863006879	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
452863006880	putative metal binding site [ion binding]; other site
452863006881	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
452863006882	nudix motif; other site
452863006883	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
452863006884	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
452863006885	active site
452863006886	metal binding site [ion binding]; metal-binding site
452863006887	homotetramer interface [polypeptide binding]; other site
452863006888	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
452863006889	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
452863006890	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
452863006891	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
452863006892	N-acetyl-D-glucosamine binding site [chemical binding]; other site
452863006893	catalytic residue [active]
452863006894	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863006895	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
452863006896	NlpC/P60 family; Region: NLPC_P60; cl17555
452863006897	Uncharacterized conserved protein [Function unknown]; Region: COG0397
452863006898	hypothetical protein; Validated; Region: PRK00029
452863006899	ribonuclease Z; Reviewed; Region: PRK00055
452863006900	DinB superfamily; Region: DinB_2; pfam12867
452863006901	Protein of unknown function (DUF664); Region: DUF664; pfam04978
452863006902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006903	Ligand Binding Site [chemical binding]; other site
452863006904	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006905	Ligand Binding Site [chemical binding]; other site
452863006906	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006907	Ligand Binding Site [chemical binding]; other site
452863006908	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006909	Ligand Binding Site [chemical binding]; other site
452863006910	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863006911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863006912	active site
452863006913	phosphorylation site [posttranslational modification]
452863006914	intermolecular recognition site; other site
452863006915	dimerization interface [polypeptide binding]; other site
452863006916	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863006917	DNA binding residues [nucleotide binding]
452863006918	dimerization interface [polypeptide binding]; other site
452863006919	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863006920	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006921	Ligand Binding Site [chemical binding]; other site
452863006922	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
452863006923	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
452863006924	Soluble P-type ATPase [General function prediction only]; Region: COG4087
452863006925	phosphoenolpyruvate synthase; Validated; Region: PRK06464
452863006926	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
452863006927	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
452863006928	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
452863006929	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863006930	Ligand Binding Site [chemical binding]; other site
452863006931	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
452863006932	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
452863006933	Soluble P-type ATPase [General function prediction only]; Region: COG4087
452863006934	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863006935	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863006936	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
452863006937	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
452863006938	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
452863006939	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
452863006940	catalytic Zn binding site [ion binding]; other site
452863006941	structural Zn binding site [ion binding]; other site
452863006942	NAD(P) binding site [chemical binding]; other site
452863006943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
452863006944	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
452863006945	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863006946	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863006947	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863006948	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863006949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863006950	NAD(P) binding site [chemical binding]; other site
452863006951	active site
452863006952	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863006953	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863006954	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863006955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863006956	putative PBP binding loops; other site
452863006957	ABC-ATPase subunit interface; other site
452863006958	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863006959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863006960	dimer interface [polypeptide binding]; other site
452863006961	conserved gate region; other site
452863006962	putative PBP binding loops; other site
452863006963	ABC-ATPase subunit interface; other site
452863006964	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
452863006965	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
452863006966	active site
452863006967	tetramer interface [polypeptide binding]; other site
452863006968	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
452863006969	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
452863006970	NAD(P) binding site [chemical binding]; other site
452863006971	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
452863006972	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
452863006973	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
452863006974	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863006975	catalytic core [active]
452863006976	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
452863006977	conserved hypothetical protein; Region: TIGR03843
452863006978	F0F1 ATP synthase subunit B; Validated; Region: PRK06568
452863006979	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
452863006980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863006981	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863006982	salt bridge; other site
452863006983	non-specific DNA binding site [nucleotide binding]; other site
452863006984	sequence-specific DNA binding site [nucleotide binding]; other site
452863006985	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863006986	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863006987	putative substrate translocation pore; other site
452863006988	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
452863006989	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863006990	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863006991	active site
452863006992	catalytic tetrad [active]
452863006993	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
452863006994	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
452863006995	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
452863006996	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
452863006997	dimer interface [polypeptide binding]; other site
452863006998	putative radical transfer pathway; other site
452863006999	diiron center [ion binding]; other site
452863007000	tyrosyl radical; other site
452863007001	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
452863007002	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
452863007003	Class I ribonucleotide reductase; Region: RNR_I; cd01679
452863007004	active site
452863007005	dimer interface [polypeptide binding]; other site
452863007006	catalytic residues [active]
452863007007	effector binding site; other site
452863007008	R2 peptide binding site; other site
452863007009	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
452863007010	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
452863007011	catalytic residues [active]
452863007012	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
452863007013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007014	S-adenosylmethionine binding site [chemical binding]; other site
452863007015	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
452863007016	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
452863007017	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863007018	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863007019	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863007020	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
452863007021	dimerization interface [polypeptide binding]; other site
452863007022	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
452863007023	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
452863007024	FAD binding site [chemical binding]; other site
452863007025	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
452863007026	metal ion-dependent adhesion site (MIDAS); other site
452863007027	von Willebrand factor type A domain; Region: VWA_2; pfam13519
452863007028	metal ion-dependent adhesion site (MIDAS); other site
452863007029	Protein of unknown function DUF58; Region: DUF58; pfam01882
452863007030	MoxR-like ATPases [General function prediction only]; Region: COG0714
452863007031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863007032	ATP binding site [chemical binding]; other site
452863007033	Walker A motif; other site
452863007034	Walker B motif; other site
452863007035	arginine finger; other site
452863007036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863007037	putative DNA binding site [nucleotide binding]; other site
452863007038	putative Zn2+ binding site [ion binding]; other site
452863007039	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863007040	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
452863007041	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
452863007042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007043	S-adenosylmethionine binding site [chemical binding]; other site
452863007044	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
452863007045	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863007046	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
452863007047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007048	S-adenosylmethionine binding site [chemical binding]; other site
452863007049	Oligomerisation domain; Region: Oligomerisation; pfam02410
452863007050	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
452863007051	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
452863007052	active site
452863007053	(T/H)XGH motif; other site
452863007054	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
452863007055	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
452863007056	putative catalytic cysteine [active]
452863007057	gamma-glutamyl kinase; Provisional; Region: PRK05429
452863007058	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
452863007059	nucleotide binding site [chemical binding]; other site
452863007060	homotetrameric interface [polypeptide binding]; other site
452863007061	putative phosphate binding site [ion binding]; other site
452863007062	putative allosteric binding site; other site
452863007063	PUA domain; Region: PUA; pfam01472
452863007064	GTPase CgtA; Reviewed; Region: obgE; PRK12296
452863007065	GTP1/OBG; Region: GTP1_OBG; pfam01018
452863007066	Obg GTPase; Region: Obg; cd01898
452863007067	G1 box; other site
452863007068	GTP/Mg2+ binding site [chemical binding]; other site
452863007069	Switch I region; other site
452863007070	G2 box; other site
452863007071	G3 box; other site
452863007072	Switch II region; other site
452863007073	G4 box; other site
452863007074	G5 box; other site
452863007075	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
452863007076	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
452863007077	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
452863007078	multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713
452863007079	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
452863007080	dimer interface [polypeptide binding]; other site
452863007081	substrate binding site [chemical binding]; other site
452863007082	ATP binding site [chemical binding]; other site
452863007083	Putative transcription activator [Transcription]; Region: TenA; COG0819
452863007084	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
452863007085	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
452863007086	homodimer interface [polypeptide binding]; other site
452863007087	oligonucleotide binding site [chemical binding]; other site
452863007088	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
452863007089	putative active site [active]
452863007090	redox center [active]
452863007091	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
452863007092	active site
452863007093	multimer interface [polypeptide binding]; other site
452863007094	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
452863007095	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
452863007096	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
452863007097	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
452863007098	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
452863007099	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
452863007100	HIGH motif; other site
452863007101	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
452863007102	active site
452863007103	KMSKS motif; other site
452863007104	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
452863007105	tRNA binding surface [nucleotide binding]; other site
452863007106	anticodon binding site; other site
452863007107	putative catalytic site [active]
452863007108	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
452863007109	putative metal binding site [ion binding]; other site
452863007110	putative phosphate binding site [ion binding]; other site
452863007111	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
452863007112	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
452863007113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863007114	NAD(P) binding site [chemical binding]; other site
452863007115	active site
452863007116	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
452863007117	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863007118	active site
452863007119	HIGH motif; other site
452863007120	nucleotide binding site [chemical binding]; other site
452863007121	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863007122	active site
452863007123	KMSKS motif; other site
452863007124	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
452863007125	tRNA binding surface [nucleotide binding]; other site
452863007126	anticodon binding site; other site
452863007127	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
452863007128	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
452863007129	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
452863007130	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
452863007131	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
452863007132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863007133	Walker A motif; other site
452863007134	ATP binding site [chemical binding]; other site
452863007135	Walker B motif; other site
452863007136	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
452863007137	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
452863007138	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
452863007139	oligomer interface [polypeptide binding]; other site
452863007140	active site residues [active]
452863007141	Clp protease; Region: CLP_protease; pfam00574
452863007142	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
452863007143	oligomer interface [polypeptide binding]; other site
452863007144	active site residues [active]
452863007145	trigger factor; Provisional; Region: tig; PRK01490
452863007146	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
452863007147	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
452863007148	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
452863007149	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
452863007150	putative DNA binding site [nucleotide binding]; other site
452863007151	catalytic residue [active]
452863007152	putative H2TH interface [polypeptide binding]; other site
452863007153	putative catalytic residues [active]
452863007154	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
452863007155	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
452863007156	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
452863007157	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
452863007158	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
452863007159	Zn binding site [ion binding]; other site
452863007160	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
452863007161	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863007162	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
452863007163	NAD(P) binding site [chemical binding]; other site
452863007164	active site
452863007165	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
452863007166	Mechanosensitive ion channel; Region: MS_channel; pfam00924
452863007167	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
452863007168	apolar tunnel; other site
452863007169	heme binding site [chemical binding]; other site
452863007170	dimerization interface [polypeptide binding]; other site
452863007171	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
452863007172	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
452863007173	active site
452863007174	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
452863007175	catalytic triad [active]
452863007176	dimer interface [polypeptide binding]; other site
452863007177	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
452863007178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863007179	Walker A/P-loop; other site
452863007180	ATP binding site [chemical binding]; other site
452863007181	Q-loop/lid; other site
452863007182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863007183	ABC transporter signature motif; other site
452863007184	Walker B; other site
452863007185	D-loop; other site
452863007186	ABC transporter; Region: ABC_tran_2; pfam12848
452863007187	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863007188	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
452863007189	dimer interface [polypeptide binding]; other site
452863007190	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
452863007191	ssDNA binding site [nucleotide binding]; other site
452863007192	tetramer (dimer of dimers) interface [polypeptide binding]; other site
452863007193	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
452863007194	xylose isomerase; Provisional; Region: PRK12677
452863007195	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
452863007196	nucleotide binding site [chemical binding]; other site
452863007197	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863007198	Protein of unknown function (DUF993); Region: DUF993; pfam06187
452863007199	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863007200	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863007201	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863007202	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863007203	DNA binding site [nucleotide binding]
452863007204	domain linker motif; other site
452863007205	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863007206	dimerization interface [polypeptide binding]; other site
452863007207	ligand binding site [chemical binding]; other site
452863007208	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
452863007209	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863007210	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
452863007211	active site
452863007212	catalytic residues [active]
452863007213	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
452863007214	A new structural DNA glycosylase; Region: AlkD_like; cl11434
452863007215	active site
452863007216	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
452863007217	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
452863007218	catalytic site [active]
452863007219	putative active site [active]
452863007220	putative substrate binding site [chemical binding]; other site
452863007221	dimer interface [polypeptide binding]; other site
452863007222	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
452863007223	active site
452863007224	catalytic residues [active]
452863007225	metal binding site [ion binding]; metal-binding site
452863007226	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
452863007227	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
452863007228	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
452863007229	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
452863007230	TspO/MBR family; Region: TspO_MBR; pfam03073
452863007231	hypothetical protein; Validated; Region: PRK02101
452863007232	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
452863007233	Putative zinc ribbon domain; Region: DUF164; pfam02591
452863007234	Uncharacterized conserved protein [Function unknown]; Region: COG0327
452863007235	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
452863007236	methionine sulfoxide reductase A; Provisional; Region: PRK14054
452863007237	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
452863007238	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
452863007239	dimer interface [polypeptide binding]; other site
452863007240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863007241	catalytic residue [active]
452863007242	serine O-acetyltransferase; Region: cysE; TIGR01172
452863007243	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
452863007244	trimer interface [polypeptide binding]; other site
452863007245	active site
452863007246	substrate binding site [chemical binding]; other site
452863007247	CoA binding site [chemical binding]; other site
452863007248	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863007249	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
452863007250	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
452863007251	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863007252	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863007253	DNA-binding site [nucleotide binding]; DNA binding site
452863007254	FCD domain; Region: FCD; pfam07729
452863007255	NAD-dependent deacetylase; Provisional; Region: PRK00481
452863007256	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
452863007257	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
452863007258	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
452863007259	dimer interface [polypeptide binding]; other site
452863007260	catalytic triad [active]
452863007261	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
452863007262	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
452863007263	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
452863007264	dimer interface [polypeptide binding]; other site
452863007265	TPP-binding site [chemical binding]; other site
452863007266	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
452863007267	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
452863007268	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
452863007269	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
452863007270	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
452863007271	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
452863007272	dimer interface [polypeptide binding]; other site
452863007273	active site
452863007274	CoA binding pocket [chemical binding]; other site
452863007275	acyl carrier protein; Provisional; Region: acpP; PRK00982
452863007276	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
452863007277	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
452863007278	dimer interface [polypeptide binding]; other site
452863007279	active site
452863007280	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
452863007281	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
452863007282	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
452863007283	active site
452863007284	DNA binding site [nucleotide binding]
452863007285	Int/Topo IB signature motif; other site
452863007286	DNA protecting protein DprA; Region: dprA; TIGR00732
452863007287	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
452863007288	hypothetical protein; Reviewed; Region: PRK12497
452863007289	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
452863007290	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
452863007291	RNA/DNA hybrid binding site [nucleotide binding]; other site
452863007292	active site
452863007293	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
452863007294	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863007295	Catalytic site [active]
452863007296	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
452863007297	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863007298	Catalytic site [active]
452863007299	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
452863007300	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
452863007301	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
452863007302	RimM N-terminal domain; Region: RimM; pfam01782
452863007303	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
452863007304	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
452863007305	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
452863007306	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
452863007307	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
452863007308	putative metal binding site [ion binding]; other site
452863007309	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863007310	active site
452863007311	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
452863007312	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863007313	active site
452863007314	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
452863007315	ThiC-associated domain; Region: ThiC-associated; pfam13667
452863007316	ThiC family; Region: ThiC; pfam01964
452863007317	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863007318	signal recognition particle protein; Provisional; Region: PRK10867
452863007319	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
452863007320	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
452863007321	P loop; other site
452863007322	GTP binding site [chemical binding]; other site
452863007323	Signal peptide binding domain; Region: SRP_SPB; pfam02978
452863007324	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
452863007325	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
452863007326	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
452863007327	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
452863007328	Nitrogen regulatory protein P-II; Region: P-II; smart00938
452863007329	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
452863007330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863007331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863007332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863007333	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
452863007334	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
452863007335	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863007336	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
452863007337	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
452863007338	Walker A/P-loop; other site
452863007339	ATP binding site [chemical binding]; other site
452863007340	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
452863007341	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
452863007342	ABC transporter signature motif; other site
452863007343	Walker B; other site
452863007344	D-loop; other site
452863007345	H-loop/switch region; other site
452863007346	translocation protein TolB; Provisional; Region: tolB; PRK03629
452863007347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863007348	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863007349	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
452863007350	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
452863007351	DNA binding site [nucleotide binding]
452863007352	catalytic residue [active]
452863007353	H2TH interface [polypeptide binding]; other site
452863007354	putative catalytic residues [active]
452863007355	turnover-facilitating residue; other site
452863007356	intercalation triad [nucleotide binding]; other site
452863007357	8OG recognition residue [nucleotide binding]; other site
452863007358	putative reading head residues; other site
452863007359	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
452863007360	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
452863007361	ribonuclease III; Reviewed; Region: rnc; PRK00102
452863007362	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
452863007363	dimerization interface [polypeptide binding]; other site
452863007364	active site
452863007365	metal binding site [ion binding]; metal-binding site
452863007366	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
452863007367	dsRNA binding site [nucleotide binding]; other site
452863007368	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
452863007369	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
452863007370	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
452863007371	active site
452863007372	(T/H)XGH motif; other site
452863007373	aminotransferase; Validated; Region: PRK07777
452863007374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863007375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863007376	homodimer interface [polypeptide binding]; other site
452863007377	catalytic residue [active]
452863007378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
452863007379	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
452863007380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007381	S-adenosylmethionine binding site [chemical binding]; other site
452863007382	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
452863007383	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
452863007384	generic binding surface II; other site
452863007385	ssDNA binding site; other site
452863007386	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863007387	ATP binding site [chemical binding]; other site
452863007388	putative Mg++ binding site [ion binding]; other site
452863007389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863007390	nucleotide binding region [chemical binding]; other site
452863007391	ATP-binding site [chemical binding]; other site
452863007392	DAK2 domain; Region: Dak2; pfam02734
452863007393	thiamine monophosphate kinase; Provisional; Region: PRK05731
452863007394	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
452863007395	ATP binding site [chemical binding]; other site
452863007396	dimerization interface [polypeptide binding]; other site
452863007397	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
452863007398	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
452863007399	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
452863007400	ATP-grasp domain; Region: ATP-grasp_4; cl17255
452863007401	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
452863007402	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
452863007403	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
452863007404	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
452863007405	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
452863007406	putative acyl-acceptor binding pocket; other site
452863007407	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
452863007408	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
452863007409	hinge; other site
452863007410	active site
452863007411	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
452863007412	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
452863007413	substrate binding site [chemical binding]; other site
452863007414	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
452863007415	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
452863007416	substrate binding site [chemical binding]; other site
452863007417	ligand binding site [chemical binding]; other site
452863007418	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863007419	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863007420	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863007421	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
452863007422	YfjP GTPase; Region: YfjP; cd11383
452863007423	G1 box; other site
452863007424	GTP/Mg2+ binding site [chemical binding]; other site
452863007425	Switch I region; other site
452863007426	G2 box; other site
452863007427	Switch II region; other site
452863007428	G3 box; other site
452863007429	G4 box; other site
452863007430	G5 box; other site
452863007431	Dynamin family; Region: Dynamin_N; pfam00350
452863007432	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
452863007433	G1 box; other site
452863007434	GTP/Mg2+ binding site [chemical binding]; other site
452863007435	G2 box; other site
452863007436	Switch I region; other site
452863007437	Predicted membrane protein [Function unknown]; Region: COG1511
452863007438	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
452863007439	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863007440	motif II; other site
452863007441	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
452863007442	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
452863007443	HIGH motif; other site
452863007444	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
452863007445	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
452863007446	active site
452863007447	KMSKS motif; other site
452863007448	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863007449	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
452863007450	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863007451	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863007452	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
452863007453	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
452863007454	homodimer interface [polypeptide binding]; other site
452863007455	substrate-cofactor binding pocket; other site
452863007456	catalytic residue [active]
452863007457	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
452863007458	tartrate dehydrogenase; Region: TTC; TIGR02089
452863007459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
452863007460	Histidine kinase; Region: HisKA_3; pfam07730
452863007461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863007462	ATP binding site [chemical binding]; other site
452863007463	Mg2+ binding site [ion binding]; other site
452863007464	G-X-G motif; other site
452863007465	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863007466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863007467	active site
452863007468	phosphorylation site [posttranslational modification]
452863007469	intermolecular recognition site; other site
452863007470	dimerization interface [polypeptide binding]; other site
452863007471	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863007472	DNA binding residues [nucleotide binding]
452863007473	dimerization interface [polypeptide binding]; other site
452863007474	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863007475	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
452863007476	Walker A/P-loop; other site
452863007477	ATP binding site [chemical binding]; other site
452863007478	Q-loop/lid; other site
452863007479	ABC transporter signature motif; other site
452863007480	Walker B; other site
452863007481	D-loop; other site
452863007482	H-loop/switch region; other site
452863007483	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
452863007484	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
452863007485	FtsX-like permease family; Region: FtsX; pfam02687
452863007486	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
452863007487	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
452863007488	active site
452863007489	HIGH motif; other site
452863007490	KMSKS motif; other site
452863007491	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
452863007492	tRNA binding surface [nucleotide binding]; other site
452863007493	anticodon binding site; other site
452863007494	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
452863007495	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863007496	Walker A/P-loop; other site
452863007497	ATP binding site [chemical binding]; other site
452863007498	Q-loop/lid; other site
452863007499	ABC transporter signature motif; other site
452863007500	Walker B; other site
452863007501	D-loop; other site
452863007502	H-loop/switch region; other site
452863007503	FtsX-like permease family; Region: FtsX; pfam02687
452863007504	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
452863007505	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
452863007506	ligand binding site [chemical binding]; other site
452863007507	NAD binding site [chemical binding]; other site
452863007508	dimerization interface [polypeptide binding]; other site
452863007509	catalytic site [active]
452863007510	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
452863007511	putative L-serine binding site [chemical binding]; other site
452863007512	ketol-acid reductoisomerase; Provisional; Region: PRK05479
452863007513	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
452863007514	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
452863007515	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
452863007516	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
452863007517	putative valine binding site [chemical binding]; other site
452863007518	dimer interface [polypeptide binding]; other site
452863007519	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
452863007520	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
452863007521	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863007522	PYR/PP interface [polypeptide binding]; other site
452863007523	dimer interface [polypeptide binding]; other site
452863007524	TPP binding site [chemical binding]; other site
452863007525	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863007526	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
452863007527	TPP-binding site [chemical binding]; other site
452863007528	dimer interface [polypeptide binding]; other site
452863007529	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
452863007530	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863007531	MarR family; Region: MarR_2; pfam12802
452863007532	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
452863007533	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
452863007534	catalytic triad [active]
452863007535	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
452863007536	Fasciclin domain; Region: Fasciclin; pfam02469
452863007537	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863007538	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
452863007539	peptide binding site [polypeptide binding]; other site
452863007540	malate:quinone oxidoreductase; Validated; Region: PRK05257
452863007541	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
452863007542	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
452863007543	Protein export membrane protein; Region: SecD_SecF; cl14618
452863007544	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
452863007545	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
452863007546	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
452863007547	MarR family; Region: MarR_2; cl17246
452863007548	MarR family; Region: MarR_2; cl17246
452863007549	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
452863007550	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
452863007551	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
452863007552	Predicted membrane protein [Function unknown]; Region: COG2246
452863007553	GtrA-like protein; Region: GtrA; pfam04138
452863007554	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
452863007555	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
452863007556	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863007557	catalytic residue [active]
452863007558	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
452863007559	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
452863007560	dimerization interface [polypeptide binding]; other site
452863007561	active site
452863007562	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
452863007563	L-aspartate oxidase; Provisional; Region: PRK06175
452863007564	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
452863007565	quinolinate synthetase; Provisional; Region: PRK09375
452863007566	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
452863007567	nudix motif; other site
452863007568	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
452863007569	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
452863007570	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
452863007571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863007572	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863007573	active site
452863007574	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863007575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863007576	putative substrate translocation pore; other site
452863007577	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863007578	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863007579	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863007580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863007581	AAA domain; Region: AAA_23; pfam13476
452863007582	Walker A/P-loop; other site
452863007583	ATP binding site [chemical binding]; other site
452863007584	Q-loop/lid; other site
452863007585	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
452863007586	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863007587	ABC transporter signature motif; other site
452863007588	Walker B; other site
452863007589	D-loop; other site
452863007590	H-loop/switch region; other site
452863007591	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
452863007592	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
452863007593	active site
452863007594	metal binding site [ion binding]; metal-binding site
452863007595	DNA binding site [nucleotide binding]
452863007596	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
452863007597	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
452863007598	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
452863007599	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
452863007600	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
452863007601	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
452863007602	active site
452863007603	catalytic site [active]
452863007604	substrate binding site [chemical binding]; other site
452863007605	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
452863007606	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
452863007607	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
452863007608	active site
452863007609	dimerization interface [polypeptide binding]; other site
452863007610	ribonuclease PH; Reviewed; Region: rph; PRK00173
452863007611	Ribonuclease PH; Region: RNase_PH_bact; cd11362
452863007612	hexamer interface [polypeptide binding]; other site
452863007613	active site
452863007614	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
452863007615	glutamate racemase; Provisional; Region: PRK00865
452863007616	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
452863007617	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
452863007618	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
452863007619	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
452863007620	active site
452863007621	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
452863007622	Isochorismatase family; Region: Isochorismatase; pfam00857
452863007623	catalytic triad [active]
452863007624	conserved cis-peptide bond; other site
452863007625	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
452863007626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863007627	ATP binding site [chemical binding]; other site
452863007628	putative Mg++ binding site [ion binding]; other site
452863007629	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
452863007630	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
452863007631	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
452863007632	active site
452863007633	trimer interface [polypeptide binding]; other site
452863007634	allosteric site; other site
452863007635	active site lid [active]
452863007636	hexamer (dimer of trimers) interface [polypeptide binding]; other site
452863007637	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
452863007638	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
452863007639	Walker A/P-loop; other site
452863007640	ATP binding site [chemical binding]; other site
452863007641	Q-loop/lid; other site
452863007642	ABC transporter signature motif; other site
452863007643	Walker B; other site
452863007644	D-loop; other site
452863007645	H-loop/switch region; other site
452863007646	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
452863007647	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
452863007648	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
452863007649	active site
452863007650	FMN binding site [chemical binding]; other site
452863007651	substrate binding site [chemical binding]; other site
452863007652	homotetramer interface [polypeptide binding]; other site
452863007653	catalytic residue [active]
452863007654	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
452863007655	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
452863007656	Domain of unknown function DUF20; Region: UPF0118; pfam01594
452863007657	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
452863007658	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
452863007659	hypothetical protein; Provisional; Region: PRK03298
452863007660	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
452863007661	DNA-binding site [nucleotide binding]; DNA binding site
452863007662	RNA-binding motif; other site
452863007663	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
452863007664	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
452863007665	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
452863007666	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
452863007667	gamma subunit interface [polypeptide binding]; other site
452863007668	epsilon subunit interface [polypeptide binding]; other site
452863007669	LBP interface [polypeptide binding]; other site
452863007670	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
452863007671	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
452863007672	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
452863007673	alpha subunit interaction interface [polypeptide binding]; other site
452863007674	Walker A motif; other site
452863007675	ATP binding site [chemical binding]; other site
452863007676	Walker B motif; other site
452863007677	inhibitor binding site; inhibition site
452863007678	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
452863007679	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
452863007680	core domain interface [polypeptide binding]; other site
452863007681	delta subunit interface [polypeptide binding]; other site
452863007682	epsilon subunit interface [polypeptide binding]; other site
452863007683	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
452863007684	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
452863007685	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
452863007686	beta subunit interaction interface [polypeptide binding]; other site
452863007687	Walker A motif; other site
452863007688	ATP binding site [chemical binding]; other site
452863007689	Walker B motif; other site
452863007690	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
452863007691	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
452863007692	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
452863007693	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
452863007694	F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636
452863007695	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
452863007696	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
452863007697	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
452863007698	Mg++ binding site [ion binding]; other site
452863007699	putative catalytic motif [active]
452863007700	substrate binding site [chemical binding]; other site
452863007701	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863007702	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863007703	active site
452863007704	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
452863007705	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
452863007706	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
452863007707	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
452863007708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007709	S-adenosylmethionine binding site [chemical binding]; other site
452863007710	peptide chain release factor 1; Validated; Region: prfA; PRK00591
452863007711	This domain is found in peptide chain release factors; Region: PCRF; smart00937
452863007712	RF-1 domain; Region: RF-1; pfam00472
452863007713	transcription termination factor Rho; Provisional; Region: PRK12608
452863007714	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
452863007715	RNA binding site [nucleotide binding]; other site
452863007716	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
452863007717	multimer interface [polypeptide binding]; other site
452863007718	Walker A motif; other site
452863007719	ATP binding site [chemical binding]; other site
452863007720	Walker B motif; other site
452863007721	homoserine kinase; Provisional; Region: PRK01212
452863007722	threonine synthase; Reviewed; Region: PRK06721
452863007723	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
452863007724	homodimer interface [polypeptide binding]; other site
452863007725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863007726	catalytic residue [active]
452863007727	homoserine dehydrogenase; Provisional; Region: PRK06349
452863007728	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
452863007729	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
452863007730	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
452863007731	diaminopimelate decarboxylase; Region: lysA; TIGR01048
452863007732	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
452863007733	active site
452863007734	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
452863007735	substrate binding site [chemical binding]; other site
452863007736	catalytic residues [active]
452863007737	dimer interface [polypeptide binding]; other site
452863007738	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
452863007739	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
452863007740	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
452863007741	active site
452863007742	HIGH motif; other site
452863007743	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863007744	KMSK motif region; other site
452863007745	tRNA binding surface [nucleotide binding]; other site
452863007746	DALR anticodon binding domain; Region: DALR_1; smart00836
452863007747	anticodon binding site; other site
452863007748	FMN-binding domain; Region: FMN_bind; cl01081
452863007749	ApbE family; Region: ApbE; pfam02424
452863007750	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
452863007751	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
452863007752	FAD binding pocket [chemical binding]; other site
452863007753	conserved FAD binding motif [chemical binding]; other site
452863007754	phosphate binding motif [ion binding]; other site
452863007755	beta-alpha-beta structure motif; other site
452863007756	NAD binding pocket [chemical binding]; other site
452863007757	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
452863007758	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
452863007759	active site
452863007760	Zn binding site [ion binding]; other site
452863007761	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
452863007762	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
452863007763	conserved cys residue [active]
452863007764	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863007765	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863007766	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
452863007767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863007768	ATP binding site [chemical binding]; other site
452863007769	putative Mg++ binding site [ion binding]; other site
452863007770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863007771	nucleotide binding region [chemical binding]; other site
452863007772	ATP-binding site [chemical binding]; other site
452863007773	Helicase associated domain (HA2); Region: HA2; pfam04408
452863007774	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
452863007775	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
452863007776	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
452863007777	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
452863007778	dimer interface [polypeptide binding]; other site
452863007779	active site
452863007780	CoA binding pocket [chemical binding]; other site
452863007781	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
452863007782	nucleotide binding site/active site [active]
452863007783	HIT family signature motif; other site
452863007784	catalytic residue [active]
452863007785	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
452863007786	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
452863007787	putative NAD(P) binding site [chemical binding]; other site
452863007788	putative substrate binding site [chemical binding]; other site
452863007789	catalytic Zn binding site [ion binding]; other site
452863007790	structural Zn binding site [ion binding]; other site
452863007791	dimer interface [polypeptide binding]; other site
452863007792	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
452863007793	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
452863007794	active site residue [active]
452863007795	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
452863007796	active site residue [active]
452863007797	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
452863007798	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
452863007799	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863007800	catalytic residue [active]
452863007801	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
452863007802	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
452863007803	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
452863007804	metal binding site 2 [ion binding]; metal-binding site
452863007805	putative DNA binding helix; other site
452863007806	metal binding site 1 [ion binding]; metal-binding site
452863007807	dimer interface [polypeptide binding]; other site
452863007808	structural Zn2+ binding site [ion binding]; other site
452863007809	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
452863007810	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
452863007811	putative PBP binding regions; other site
452863007812	ABC-ATPase subunit  interface; other site
452863007813	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
452863007814	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
452863007815	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
452863007816	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
452863007817	intersubunit interface [polypeptide binding]; other site
452863007818	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
452863007819	Domain of unknown function DUF21; Region: DUF21; pfam01595
452863007820	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
452863007821	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
452863007822	Domain of unknown function DUF21; Region: DUF21; pfam01595
452863007823	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
452863007824	Transporter associated domain; Region: CorC_HlyC; smart01091
452863007825	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
452863007826	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
452863007827	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
452863007828	TPP-binding site [chemical binding]; other site
452863007829	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
452863007830	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
452863007831	active site
452863007832	catalytic triad [active]
452863007833	oxyanion hole [active]
452863007834	Uncharacterized conserved protein [Function unknown]; Region: COG3595
452863007835	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
452863007836	Predicted transcriptional regulators [Transcription]; Region: COG1695
452863007837	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
452863007838	anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin
452863007839	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
452863007840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863007841	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863007842	DNA binding residues [nucleotide binding]
452863007843	DoxX; Region: DoxX; cl17842
452863007844	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
452863007845	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
452863007846	hinge; other site
452863007847	active site
452863007848	GTPase RsgA; Reviewed; Region: PRK00098
452863007849	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
452863007850	GTPase/Zn-binding domain interface [polypeptide binding]; other site
452863007851	GTP/Mg2+ binding site [chemical binding]; other site
452863007852	G4 box; other site
452863007853	G5 box; other site
452863007854	G1 box; other site
452863007855	Switch I region; other site
452863007856	G2 box; other site
452863007857	G3 box; other site
452863007858	Switch II region; other site
452863007859	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
452863007860	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
452863007861	active site
452863007862	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
452863007863	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
452863007864	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863007865	catalytic residue [active]
452863007866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863007867	S-adenosylmethionine binding site [chemical binding]; other site
452863007868	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
452863007869	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
452863007870	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
452863007871	FeoA domain; Region: FeoA; pfam04023
452863007872	CrcB-like protein; Region: CRCB; pfam02537
452863007873	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
452863007874	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
452863007875	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
452863007876	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
452863007877	protein binding site [polypeptide binding]; other site
452863007878	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
452863007879	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
452863007880	SmpB-tmRNA interface; other site
452863007881	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
452863007882	Peptidase family M23; Region: Peptidase_M23; pfam01551
452863007883	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
452863007884	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
452863007885	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
452863007886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863007887	Walker A/P-loop; other site
452863007888	ATP binding site [chemical binding]; other site
452863007889	Q-loop/lid; other site
452863007890	ABC transporter signature motif; other site
452863007891	Walker B; other site
452863007892	D-loop; other site
452863007893	H-loop/switch region; other site
452863007894	peptide chain release factor 2; Validated; Region: prfB; PRK00578
452863007895	This domain is found in peptide chain release factors; Region: PCRF; smart00937
452863007896	RF-1 domain; Region: RF-1; pfam00472
452863007897	TadE-like protein; Region: TadE; pfam07811
452863007898	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863007899	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863007900	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863007901	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863007902	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
452863007903	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
452863007904	ATP binding site [chemical binding]; other site
452863007905	Walker A motif; other site
452863007906	hexamer interface [polypeptide binding]; other site
452863007907	Walker B motif; other site
452863007908	CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans.  CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412
452863007909	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
452863007910	active site
452863007911	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
452863007912	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
452863007913	substrate binding site; other site
452863007914	tetramer interface; other site
452863007915	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
452863007916	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
452863007917	NAD binding site [chemical binding]; other site
452863007918	substrate binding site [chemical binding]; other site
452863007919	homodimer interface [polypeptide binding]; other site
452863007920	active site
452863007921	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
452863007922	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
452863007923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863007924	NAD(P) binding site [chemical binding]; other site
452863007925	active site
452863007926	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
452863007927	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
452863007928	Ligand binding site; other site
452863007929	Putative Catalytic site; other site
452863007930	DXD motif; other site
452863007931	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863007932	active site
452863007933	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863007934	active site
452863007935	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
452863007936	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
452863007937	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
452863007938	Probable Catalytic site; other site
452863007939	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863007940	active site
452863007941	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
452863007942	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
452863007943	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
452863007944	Walker A/P-loop; other site
452863007945	ATP binding site [chemical binding]; other site
452863007946	Q-loop/lid; other site
452863007947	ABC transporter signature motif; other site
452863007948	Walker B; other site
452863007949	D-loop; other site
452863007950	H-loop/switch region; other site
452863007951	ABC-2 type transporter; Region: ABC2_membrane; cl17235
452863007952	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863007953	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863007954	active site
452863007955	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
452863007956	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863007957	UDP-galactopyranose mutase; Region: GLF; pfam03275
452863007958	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
452863007959	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
452863007960	putative trimer interface [polypeptide binding]; other site
452863007961	putative active site [active]
452863007962	putative substrate binding site [chemical binding]; other site
452863007963	putative CoA binding site [chemical binding]; other site
452863007964	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
452863007965	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
452863007966	phosphopeptide binding site; other site
452863007967	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
452863007968	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
452863007969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863007970	AAA domain; Region: AAA_22; pfam13401
452863007971	Walker A/P-loop; other site
452863007972	ATP binding site [chemical binding]; other site
452863007973	Walker B; other site
452863007974	D-loop; other site
452863007975	Transcription factor WhiB; Region: Whib; pfam02467
452863007976	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
452863007977	PAS fold; Region: PAS_4; pfam08448
452863007978	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
452863007979	Histidine kinase; Region: HisKA_2; pfam07568
452863007980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863007981	ATP binding site [chemical binding]; other site
452863007982	Mg2+ binding site [ion binding]; other site
452863007983	G-X-G motif; other site
452863007984	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
452863007985	AAA domain; Region: AAA_31; pfam13614
452863007986	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
452863007987	Helix-turn-helix domain; Region: HTH_17; pfam12728
452863007988	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863007989	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
452863007990	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
452863007991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
452863007992	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
452863007993	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
452863007994	30S subunit binding site; other site
452863007995	comF family protein; Region: comF; TIGR00201
452863007996	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863007997	active site
452863007998	lipoprotein LpqB; Provisional; Region: PRK13614
452863007999	Sporulation and spore germination; Region: Germane; pfam10646
452863008000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863008001	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
452863008002	dimerization interface [polypeptide binding]; other site
452863008003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863008004	dimer interface [polypeptide binding]; other site
452863008005	phosphorylation site [posttranslational modification]
452863008006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863008007	ATP binding site [chemical binding]; other site
452863008008	G-X-G motif; other site
452863008009	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863008010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863008011	active site
452863008012	phosphorylation site [posttranslational modification]
452863008013	intermolecular recognition site; other site
452863008014	dimerization interface [polypeptide binding]; other site
452863008015	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863008016	DNA binding site [nucleotide binding]
452863008017	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
452863008018	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
452863008019	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
452863008020	MoxR-like ATPases [General function prediction only]; Region: COG0714
452863008021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863008022	Walker A motif; other site
452863008023	ATP binding site [chemical binding]; other site
452863008024	Walker B motif; other site
452863008025	arginine finger; other site
452863008026	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
452863008027	Protein of unknown function DUF58; Region: DUF58; pfam01882
452863008028	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
452863008029	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
452863008030	chorismate mutase; Provisional; Region: PRK09239
452863008031	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
452863008032	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863008033	Walker A/P-loop; other site
452863008034	ATP binding site [chemical binding]; other site
452863008035	Q-loop/lid; other site
452863008036	ABC transporter signature motif; other site
452863008037	Walker B; other site
452863008038	D-loop; other site
452863008039	H-loop/switch region; other site
452863008040	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863008041	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863008042	Walker A/P-loop; other site
452863008043	ATP binding site [chemical binding]; other site
452863008044	Q-loop/lid; other site
452863008045	ABC transporter signature motif; other site
452863008046	Walker B; other site
452863008047	D-loop; other site
452863008048	H-loop/switch region; other site
452863008049	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863008050	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
452863008051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008052	dimer interface [polypeptide binding]; other site
452863008053	conserved gate region; other site
452863008054	ABC-ATPase subunit interface; other site
452863008055	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863008056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008057	dimer interface [polypeptide binding]; other site
452863008058	conserved gate region; other site
452863008059	putative PBP binding loops; other site
452863008060	ABC-ATPase subunit interface; other site
452863008061	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
452863008062	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
452863008063	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
452863008064	Ligand Binding Site [chemical binding]; other site
452863008065	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
452863008066	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
452863008067	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
452863008068	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863008069	catalytic residue [active]
452863008070	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
452863008071	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
452863008072	HSP70 interaction site [polypeptide binding]; other site
452863008073	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
452863008074	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
452863008075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863008076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863008077	DNA binding residues [nucleotide binding]
452863008078	Anti-sigma-K factor rskA; Region: RskA; pfam10099
452863008079	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
452863008080	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
452863008081	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
452863008082	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
452863008083	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
452863008084	Ligand binding site [chemical binding]; other site
452863008085	Electron transfer flavoprotein domain; Region: ETF; pfam01012
452863008086	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
452863008087	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
452863008088	protein binding site [polypeptide binding]; other site
452863008089	Repair protein; Region: Repair_PSII; pfam04536
452863008090	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
452863008091	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
452863008092	DNA photolyase; Region: DNA_photolyase; pfam00875
452863008093	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
452863008094	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
452863008095	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
452863008096	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
452863008097	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
452863008098	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
452863008099	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
452863008100	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
452863008101	Protein of unknown function DUF45; Region: DUF45; cl00636
452863008102	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
452863008103	Part of AAA domain; Region: AAA_19; pfam13245
452863008104	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
452863008105	Family description; Region: UvrD_C_2; pfam13538
452863008106	HRDC domain; Region: HRDC; pfam00570
452863008107	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
452863008108	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
452863008109	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
452863008110	putative NADH binding site [chemical binding]; other site
452863008111	putative active site [active]
452863008112	nudix motif; other site
452863008113	putative metal binding site [ion binding]; other site
452863008114	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
452863008115	Phosphotransferase enzyme family; Region: APH; pfam01636
452863008116	active site
452863008117	ATP binding site [chemical binding]; other site
452863008118	substrate binding site [chemical binding]; other site
452863008119	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
452863008120	Part of AAA domain; Region: AAA_19; pfam13245
452863008121	Family description; Region: UvrD_C_2; pfam13538
452863008122	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
452863008123	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
452863008124	Part of AAA domain; Region: AAA_19; pfam13245
452863008125	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
452863008126	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
452863008127	DNA binding site [nucleotide binding]
452863008128	active site
452863008129	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
452863008130	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
452863008131	active site
452863008132	catalytic site [active]
452863008133	substrate binding site [chemical binding]; other site
452863008134	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863008135	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863008136	substrate binding pocket [chemical binding]; other site
452863008137	membrane-bound complex binding site; other site
452863008138	hinge residues; other site
452863008139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008140	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
452863008141	dimer interface [polypeptide binding]; other site
452863008142	conserved gate region; other site
452863008143	putative PBP binding loops; other site
452863008144	ABC-ATPase subunit interface; other site
452863008145	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863008146	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
452863008147	Walker A/P-loop; other site
452863008148	ATP binding site [chemical binding]; other site
452863008149	Q-loop/lid; other site
452863008150	ABC transporter signature motif; other site
452863008151	Walker B; other site
452863008152	D-loop; other site
452863008153	H-loop/switch region; other site
452863008154	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
452863008155	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
452863008156	inhibitor-cofactor binding pocket; inhibition site
452863008157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863008158	catalytic residue [active]
452863008159	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863008160	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863008161	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
452863008162	dimer interface [polypeptide binding]; other site
452863008163	active site
452863008164	Schiff base residues; other site
452863008165	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
452863008166	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
452863008167	active site
452863008168	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
452863008169	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
452863008170	domain interfaces; other site
452863008171	active site
452863008172	ferrochelatase; Reviewed; Region: hemH; PRK00035
452863008173	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
452863008174	C-terminal domain interface [polypeptide binding]; other site
452863008175	active site
452863008176	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
452863008177	active site
452863008178	N-terminal domain interface [polypeptide binding]; other site
452863008179	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
452863008180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863008181	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
452863008182	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
452863008183	substrate binding site [chemical binding]; other site
452863008184	active site
452863008185	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
452863008186	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
452863008187	NAD(P) binding pocket [chemical binding]; other site
452863008188	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
452863008189	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
452863008190	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
452863008191	ATP binding site [chemical binding]; other site
452863008192	substrate interface [chemical binding]; other site
452863008193	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
452863008194	active site residue [active]
452863008195	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863008196	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863008197	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
452863008198	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
452863008199	ThiS interaction site; other site
452863008200	putative active site [active]
452863008201	tetramer interface [polypeptide binding]; other site
452863008202	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
452863008203	thiS-thiF/thiG interaction site; other site
452863008204	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
452863008205	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
452863008206	thiamine phosphate binding site [chemical binding]; other site
452863008207	active site
452863008208	pyrophosphate binding site [ion binding]; other site
452863008209	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
452863008210	RNB domain; Region: RNB; pfam00773
452863008211	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
452863008212	DEAD-like helicases superfamily; Region: DEXDc; smart00487
452863008213	ATP binding site [chemical binding]; other site
452863008214	Mg++ binding site [ion binding]; other site
452863008215	motif III; other site
452863008216	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863008217	nucleotide binding region [chemical binding]; other site
452863008218	ATP-binding site [chemical binding]; other site
452863008219	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
452863008220	DNA methylase; Region: N6_N4_Mtase; pfam01555
452863008221	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
452863008222	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
452863008223	active site
452863008224	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
452863008225	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
452863008226	proline aminopeptidase P II; Provisional; Region: PRK10879
452863008227	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
452863008228	active site
452863008229	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
452863008230	Serine incorporator (Serinc); Region: Serinc; pfam03348
452863008231	PRC-barrel domain; Region: PRC; pfam05239
452863008232	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
452863008233	MgtE intracellular N domain; Region: MgtE_N; smart00924
452863008234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
452863008235	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
452863008236	antiporter inner membrane protein; Provisional; Region: PRK11670
452863008237	Domain of unknown function DUF59; Region: DUF59; pfam01883
452863008238	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
452863008239	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
452863008240	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
452863008241	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863008242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863008243	DNA binding residues [nucleotide binding]
452863008244	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
452863008245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863008246	S-adenosylmethionine binding site [chemical binding]; other site
452863008247	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
452863008248	DivIVA domain; Region: DivI1A_domain; TIGR03544
452863008249	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
452863008250	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863008251	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
452863008252	Walker A/P-loop; other site
452863008253	ATP binding site [chemical binding]; other site
452863008254	Q-loop/lid; other site
452863008255	ABC transporter signature motif; other site
452863008256	Walker B; other site
452863008257	D-loop; other site
452863008258	H-loop/switch region; other site
452863008259	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863008260	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863008261	substrate binding pocket [chemical binding]; other site
452863008262	membrane-bound complex binding site; other site
452863008263	hinge residues; other site
452863008264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008265	dimer interface [polypeptide binding]; other site
452863008266	conserved gate region; other site
452863008267	putative PBP binding loops; other site
452863008268	ABC-ATPase subunit interface; other site
452863008269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
452863008270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008271	ABC-ATPase subunit interface; other site
452863008272	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
452863008273	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
452863008274	metal binding site [ion binding]; metal-binding site
452863008275	putative dimer interface [polypeptide binding]; other site
452863008276	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
452863008277	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
452863008278	putative trimer interface [polypeptide binding]; other site
452863008279	putative CoA binding site [chemical binding]; other site
452863008280	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863008281	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
452863008282	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
452863008283	UDP-glucose 4-epimerase; Region: PLN02240
452863008284	NAD binding site [chemical binding]; other site
452863008285	homodimer interface [polypeptide binding]; other site
452863008286	active site
452863008287	substrate binding site [chemical binding]; other site
452863008288	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
452863008289	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
452863008290	dimer interface [polypeptide binding]; other site
452863008291	active site
452863008292	citrylCoA binding site [chemical binding]; other site
452863008293	NADH binding [chemical binding]; other site
452863008294	cationic pore residues; other site
452863008295	oxalacetate/citrate binding site [chemical binding]; other site
452863008296	coenzyme A binding site [chemical binding]; other site
452863008297	catalytic triad [active]
452863008298	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
452863008299	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863008300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863008301	homodimer interface [polypeptide binding]; other site
452863008302	catalytic residue [active]
452863008303	Ferredoxin [Energy production and conversion]; Region: COG1146
452863008304	4Fe-4S binding domain; Region: Fer4; pfam00037
452863008305	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
452863008306	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
452863008307	G1 box; other site
452863008308	putative GEF interaction site [polypeptide binding]; other site
452863008309	GTP/Mg2+ binding site [chemical binding]; other site
452863008310	Switch I region; other site
452863008311	G2 box; other site
452863008312	G3 box; other site
452863008313	Switch II region; other site
452863008314	G4 box; other site
452863008315	G5 box; other site
452863008316	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
452863008317	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
452863008318	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
452863008319	active site
452863008320	catalytic triad [active]
452863008321	oxyanion hole [active]
452863008322	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
452863008323	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863008324	Walker A/P-loop; other site
452863008325	ATP binding site [chemical binding]; other site
452863008326	Q-loop/lid; other site
452863008327	ABC transporter signature motif; other site
452863008328	Walker B; other site
452863008329	D-loop; other site
452863008330	H-loop/switch region; other site
452863008331	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
452863008332	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863008333	Walker A/P-loop; other site
452863008334	ATP binding site [chemical binding]; other site
452863008335	Q-loop/lid; other site
452863008336	ABC transporter signature motif; other site
452863008337	Walker B; other site
452863008338	D-loop; other site
452863008339	H-loop/switch region; other site
452863008340	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863008341	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863008342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008343	dimer interface [polypeptide binding]; other site
452863008344	conserved gate region; other site
452863008345	putative PBP binding loops; other site
452863008346	ABC-ATPase subunit interface; other site
452863008347	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863008348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008349	dimer interface [polypeptide binding]; other site
452863008350	conserved gate region; other site
452863008351	ABC-ATPase subunit interface; other site
452863008352	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
452863008353	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
452863008354	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863008355	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
452863008356	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
452863008357	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
452863008358	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863008359	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863008360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863008361	NAD(P) binding site [chemical binding]; other site
452863008362	active site
452863008363	GTP-binding protein YchF; Reviewed; Region: PRK09601
452863008364	YchF GTPase; Region: YchF; cd01900
452863008365	G1 box; other site
452863008366	GTP/Mg2+ binding site [chemical binding]; other site
452863008367	Switch I region; other site
452863008368	G2 box; other site
452863008369	Switch II region; other site
452863008370	G3 box; other site
452863008371	G4 box; other site
452863008372	G5 box; other site
452863008373	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
452863008374	RmuC family; Region: RmuC; pfam02646
452863008375	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
452863008376	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
452863008377	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
452863008378	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
452863008379	generic binding surface II; other site
452863008380	generic binding surface I; other site
452863008381	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
452863008382	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
452863008383	aminotransferase AlaT; Validated; Region: PRK09265
452863008384	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863008385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863008386	homodimer interface [polypeptide binding]; other site
452863008387	catalytic residue [active]
452863008388	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
452863008389	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
452863008390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008391	ABC-ATPase subunit interface; other site
452863008392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008393	dimer interface [polypeptide binding]; other site
452863008394	conserved gate region; other site
452863008395	ABC-ATPase subunit interface; other site
452863008396	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863008397	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
452863008398	Walker A/P-loop; other site
452863008399	ATP binding site [chemical binding]; other site
452863008400	Q-loop/lid; other site
452863008401	ABC transporter signature motif; other site
452863008402	Walker B; other site
452863008403	D-loop; other site
452863008404	H-loop/switch region; other site
452863008405	Pirin-related protein [General function prediction only]; Region: COG1741
452863008406	Pirin; Region: Pirin; pfam02678
452863008407	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
452863008408	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
452863008409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863008410	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863008411	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
452863008412	putative dimerization interface [polypeptide binding]; other site
452863008413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863008414	putative substrate translocation pore; other site
452863008415	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
452863008416	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863008417	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
452863008418	putative DNA binding site [nucleotide binding]; other site
452863008419	putative Zn2+ binding site [ion binding]; other site
452863008420	AsnC family; Region: AsnC_trans_reg; pfam01037
452863008421	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863008422	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
452863008423	dimerization interface [polypeptide binding]; other site
452863008424	putative DNA binding site [nucleotide binding]; other site
452863008425	putative Zn2+ binding site [ion binding]; other site
452863008426	AsnC family; Region: AsnC_trans_reg; pfam01037
452863008427	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
452863008428	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
452863008429	oligomer interface [polypeptide binding]; other site
452863008430	metal binding site [ion binding]; metal-binding site
452863008431	metal binding site [ion binding]; metal-binding site
452863008432	putative Cl binding site [ion binding]; other site
452863008433	basic sphincter; other site
452863008434	hydrophobic gate; other site
452863008435	periplasmic entrance; other site
452863008436	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
452863008437	nudix motif; other site
452863008438	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
452863008439	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
452863008440	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
452863008441	active site
452863008442	nucleotide binding site [chemical binding]; other site
452863008443	HIGH motif; other site
452863008444	KMSKS motif; other site
452863008445	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
452863008446	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
452863008447	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863008448	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
452863008449	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
452863008450	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
452863008451	active site
452863008452	tetramer interface; other site
452863008453	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
452863008454	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
452863008455	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
452863008456	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
452863008457	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
452863008458	Part of AAA domain; Region: AAA_19; pfam13245
452863008459	GMP synthase; Reviewed; Region: guaA; PRK00074
452863008460	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
452863008461	AMP/PPi binding site [chemical binding]; other site
452863008462	candidate oxyanion hole; other site
452863008463	catalytic triad [active]
452863008464	potential glutamine specificity residues [chemical binding]; other site
452863008465	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
452863008466	ATP Binding subdomain [chemical binding]; other site
452863008467	Ligand Binding sites [chemical binding]; other site
452863008468	Dimerization subdomain; other site
452863008469	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
452863008470	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
452863008471	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
452863008472	active site
452863008473	phosphorylation site [posttranslational modification]
452863008474	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
452863008475	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
452863008476	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
452863008477	active site
452863008478	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
452863008479	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863008480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863008481	Walker A/P-loop; other site
452863008482	ATP binding site [chemical binding]; other site
452863008483	Q-loop/lid; other site
452863008484	ABC transporter signature motif; other site
452863008485	Walker B; other site
452863008486	D-loop; other site
452863008487	H-loop/switch region; other site
452863008488	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
452863008489	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
452863008490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
452863008491	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
452863008492	active site
452863008493	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
452863008494	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
452863008495	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
452863008496	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863008497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863008498	DNA binding residues [nucleotide binding]
452863008499	dimerization interface [polypeptide binding]; other site
452863008500	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
452863008501	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
452863008502	active site
452863008503	DNA binding site [nucleotide binding]
452863008504	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
452863008505	DNA binding site [nucleotide binding]
452863008506	RibD C-terminal domain; Region: RibD_C; cl17279
452863008507	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
452863008508	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
452863008509	ring oligomerisation interface [polypeptide binding]; other site
452863008510	ATP/Mg binding site [chemical binding]; other site
452863008511	stacking interactions; other site
452863008512	hinge regions; other site
452863008513	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
452863008514	oligomerisation interface [polypeptide binding]; other site
452863008515	mobile loop; other site
452863008516	roof hairpin; other site
452863008517	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
452863008518	EamA-like transporter family; Region: EamA; pfam00892
452863008519	EamA-like transporter family; Region: EamA; pfam00892
452863008520	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
452863008521	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
452863008522	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
452863008523	shikimate binding site; other site
452863008524	NAD(P) binding site [chemical binding]; other site
452863008525	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
452863008526	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
452863008527	carboxylate-amine ligase; Provisional; Region: PRK13517
452863008528	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
452863008529	UGMP family protein; Validated; Region: PRK09604
452863008530	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
452863008531	Fumble; Region: Fumble; cl17357
452863008532	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
452863008533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863008534	Coenzyme A binding pocket [chemical binding]; other site
452863008535	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
452863008536	Glycoprotease family; Region: Peptidase_M22; pfam00814
452863008537	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
452863008538	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
452863008539	alanine racemase; Reviewed; Region: alr; PRK00053
452863008540	active site
452863008541	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
452863008542	dimer interface [polypeptide binding]; other site
452863008543	substrate binding site [chemical binding]; other site
452863008544	catalytic residues [active]
452863008545	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
452863008546	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863008547	substrate binding site [chemical binding]; other site
452863008548	ATP binding site [chemical binding]; other site
452863008549	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
452863008550	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
452863008551	NAD(P) binding site [chemical binding]; other site
452863008552	LDH/MDH dimer interface [polypeptide binding]; other site
452863008553	substrate binding site [chemical binding]; other site
452863008554	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
452863008555	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
452863008556	putative ADP-binding pocket [chemical binding]; other site
452863008557	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
452863008558	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
452863008559	Potassium binding sites [ion binding]; other site
452863008560	Cesium cation binding sites [ion binding]; other site
452863008561	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863008562	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863008563	putative active site [active]
452863008564	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
452863008565	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
452863008566	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863008567	DNA binding residues [nucleotide binding]
452863008568	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
452863008569	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
452863008570	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863008571	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863008572	active site
452863008573	catalytic tetrad [active]
452863008574	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
452863008575	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
452863008576	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
452863008577	catalytic site [active]
452863008578	active site
452863008579	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
452863008580	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
452863008581	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
452863008582	active site
452863008583	catalytic site [active]
452863008584	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
452863008585	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
452863008586	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
452863008587	active site
452863008588	catalytic site [active]
452863008589	Uncharacterized conserved protein [Function unknown]; Region: COG0062
452863008590	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
452863008591	putative substrate binding site [chemical binding]; other site
452863008592	putative ATP binding site [chemical binding]; other site
452863008593	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
452863008594	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
452863008595	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
452863008596	glutaminase active site [active]
452863008597	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
452863008598	dimer interface [polypeptide binding]; other site
452863008599	active site
452863008600	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
452863008601	dimer interface [polypeptide binding]; other site
452863008602	active site
452863008603	pantothenate kinase; Provisional; Region: PRK05439
452863008604	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
452863008605	ATP-binding site [chemical binding]; other site
452863008606	CoA-binding site [chemical binding]; other site
452863008607	Mg2+-binding site [ion binding]; other site
452863008608	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
452863008609	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
452863008610	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
452863008611	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
452863008612	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
452863008613	active site
452863008614	substrate binding site [chemical binding]; other site
452863008615	metal binding site [ion binding]; metal-binding site
452863008616	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
452863008617	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
452863008618	Ligand binding site; other site
452863008619	Ligand binding site; other site
452863008620	Ligand binding site; other site
452863008621	Putative Catalytic site; other site
452863008622	DXD motif; other site
452863008623	Predicted membrane protein [Function unknown]; Region: COG2246
452863008624	GtrA-like protein; Region: GtrA; pfam04138
452863008625	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
452863008626	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
452863008627	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
452863008628	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
452863008629	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
452863008630	23S rRNA interface [nucleotide binding]; other site
452863008631	L3 interface [polypeptide binding]; other site
452863008632	TadE-like protein; Region: TadE; pfam07811
452863008633	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
452863008634	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
452863008635	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
452863008636	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863008637	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863008638	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
452863008639	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
452863008640	ATP binding site [chemical binding]; other site
452863008641	Walker A motif; other site
452863008642	hexamer interface [polypeptide binding]; other site
452863008643	Walker B motif; other site
452863008644	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863008645	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863008646	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863008647	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863008648	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
452863008649	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
452863008650	TadE-like protein; Region: TadE; pfam07811
452863008651	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
452863008652	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
452863008653	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863008654	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
452863008655	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
452863008656	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
452863008657	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
452863008658	ATP binding site [chemical binding]; other site
452863008659	Walker A motif; other site
452863008660	hexamer interface [polypeptide binding]; other site
452863008661	Walker B motif; other site
452863008662	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
452863008663	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863008664	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
452863008665	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
452863008666	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863008667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863008668	active site
452863008669	phosphorylation site [posttranslational modification]
452863008670	intermolecular recognition site; other site
452863008671	dimerization interface [polypeptide binding]; other site
452863008672	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863008673	DNA binding site [nucleotide binding]
452863008674	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
452863008675	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
452863008676	dimerization interface 3.5A [polypeptide binding]; other site
452863008677	active site
452863008678	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
452863008679	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
452863008680	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
452863008681	alphaNTD homodimer interface [polypeptide binding]; other site
452863008682	alphaNTD - beta interaction site [polypeptide binding]; other site
452863008683	alphaNTD - beta' interaction site [polypeptide binding]; other site
452863008684	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
452863008685	30S ribosomal protein S11; Validated; Region: PRK05309
452863008686	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
452863008687	30S ribosomal protein S13; Region: bact_S13; TIGR03631
452863008688	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
452863008689	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
452863008690	rRNA binding site [nucleotide binding]; other site
452863008691	predicted 30S ribosome binding site; other site
452863008692	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
452863008693	putative active site pocket [active]
452863008694	cleavage site
452863008695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008696	dimer interface [polypeptide binding]; other site
452863008697	conserved gate region; other site
452863008698	putative PBP binding loops; other site
452863008699	ABC-ATPase subunit interface; other site
452863008700	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863008701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863008702	dimer interface [polypeptide binding]; other site
452863008703	conserved gate region; other site
452863008704	putative PBP binding loops; other site
452863008705	ABC-ATPase subunit interface; other site
452863008706	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863008707	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
452863008708	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
452863008709	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863008710	sequence-specific DNA binding site [nucleotide binding]; other site
452863008711	salt bridge; other site
452863008712	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
452863008713	active site
452863008714	adenylate kinase; Reviewed; Region: adk; PRK00279
452863008715	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
452863008716	AMP-binding site [chemical binding]; other site
452863008717	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
452863008718	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
452863008719	SecY translocase; Region: SecY; pfam00344
452863008720	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
452863008721	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
452863008722	23S rRNA binding site [nucleotide binding]; other site
452863008723	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
452863008724	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
452863008725	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
452863008726	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
452863008727	5S rRNA interface [nucleotide binding]; other site
452863008728	23S rRNA interface [nucleotide binding]; other site
452863008729	L5 interface [polypeptide binding]; other site
452863008730	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
452863008731	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
452863008732	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
452863008733	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
452863008734	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
452863008735	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
452863008736	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
452863008737	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
452863008738	RNA binding site [nucleotide binding]; other site
452863008739	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
452863008740	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
452863008741	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
452863008742	23S rRNA interface [nucleotide binding]; other site
452863008743	putative translocon interaction site; other site
452863008744	signal recognition particle (SRP54) interaction site; other site
452863008745	L23 interface [polypeptide binding]; other site
452863008746	trigger factor interaction site; other site
452863008747	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
452863008748	23S rRNA interface [nucleotide binding]; other site
452863008749	5S rRNA interface [nucleotide binding]; other site
452863008750	putative antibiotic binding site [chemical binding]; other site
452863008751	L25 interface [polypeptide binding]; other site
452863008752	L27 interface [polypeptide binding]; other site
452863008753	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
452863008754	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
452863008755	G-X-X-G motif; other site
452863008756	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
452863008757	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
452863008758	putative translocon binding site; other site
452863008759	protein-rRNA interface [nucleotide binding]; other site
452863008760	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
452863008761	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
452863008762	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
452863008763	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
452863008764	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
452863008765	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
452863008766	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
452863008767	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
452863008768	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
452863008769	beta-galactosidase; Region: BGL; TIGR03356
452863008770	elongation factor Tu; Reviewed; Region: PRK00049
452863008771	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
452863008772	G1 box; other site
452863008773	GEF interaction site [polypeptide binding]; other site
452863008774	GTP/Mg2+ binding site [chemical binding]; other site
452863008775	Switch I region; other site
452863008776	G2 box; other site
452863008777	G3 box; other site
452863008778	Switch II region; other site
452863008779	G4 box; other site
452863008780	G5 box; other site
452863008781	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
452863008782	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
452863008783	Antibiotic Binding Site [chemical binding]; other site
452863008784	elongation factor G; Reviewed; Region: PRK00007
452863008785	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
452863008786	G1 box; other site
452863008787	putative GEF interaction site [polypeptide binding]; other site
452863008788	GTP/Mg2+ binding site [chemical binding]; other site
452863008789	Switch I region; other site
452863008790	G2 box; other site
452863008791	G3 box; other site
452863008792	Switch II region; other site
452863008793	G4 box; other site
452863008794	G5 box; other site
452863008795	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
452863008796	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
452863008797	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
452863008798	30S ribosomal protein S7; Validated; Region: PRK05302
452863008799	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
452863008800	S17 interaction site [polypeptide binding]; other site
452863008801	S8 interaction site; other site
452863008802	16S rRNA interaction site [nucleotide binding]; other site
452863008803	streptomycin interaction site [chemical binding]; other site
452863008804	23S rRNA interaction site [nucleotide binding]; other site
452863008805	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
452863008806	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
452863008807	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
452863008808	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
452863008809	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
452863008810	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
452863008811	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
452863008812	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
452863008813	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
452863008814	DNA binding site [nucleotide binding]
452863008815	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
452863008816	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
452863008817	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
452863008818	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
452863008819	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
452863008820	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
452863008821	RPB10 interaction site [polypeptide binding]; other site
452863008822	RPB1 interaction site [polypeptide binding]; other site
452863008823	RPB11 interaction site [polypeptide binding]; other site
452863008824	RPB3 interaction site [polypeptide binding]; other site
452863008825	RPB12 interaction site [polypeptide binding]; other site
452863008826	putative acyltransferase; Provisional; Region: PRK05790
452863008827	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863008828	dimer interface [polypeptide binding]; other site
452863008829	active site
452863008830	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
452863008831	putative deacylase active site [active]
452863008832	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
452863008833	core dimer interface [polypeptide binding]; other site
452863008834	peripheral dimer interface [polypeptide binding]; other site
452863008835	L10 interface [polypeptide binding]; other site
452863008836	L11 interface [polypeptide binding]; other site
452863008837	putative EF-Tu interaction site [polypeptide binding]; other site
452863008838	putative EF-G interaction site [polypeptide binding]; other site
452863008839	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
452863008840	23S rRNA interface [nucleotide binding]; other site
452863008841	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863008842	Coenzyme A binding pocket [chemical binding]; other site
452863008843	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863008844	Coenzyme A binding pocket [chemical binding]; other site
452863008845	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
452863008846	mRNA/rRNA interface [nucleotide binding]; other site
452863008847	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
452863008848	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
452863008849	23S rRNA interface [nucleotide binding]; other site
452863008850	putative thiostrepton binding site; other site
452863008851	L7/L12 interface [polypeptide binding]; other site
452863008852	L25 interface [polypeptide binding]; other site
452863008853	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
452863008854	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
452863008855	putative homodimer interface [polypeptide binding]; other site
452863008856	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
452863008857	heterodimer interface [polypeptide binding]; other site
452863008858	homodimer interface [polypeptide binding]; other site
452863008859	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
452863008860	aspartate aminotransferase; Provisional; Region: PRK05764
452863008861	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863008862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863008863	homodimer interface [polypeptide binding]; other site
452863008864	catalytic residue [active]
452863008865	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863008866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863008867	active site
452863008868	phosphorylation site [posttranslational modification]
452863008869	intermolecular recognition site; other site
452863008870	dimerization interface [polypeptide binding]; other site
452863008871	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863008872	DNA binding residues [nucleotide binding]
452863008873	dimerization interface [polypeptide binding]; other site
452863008874	PspC domain; Region: PspC; pfam04024
452863008875	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
452863008876	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
452863008877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863008878	ATP binding site [chemical binding]; other site
452863008879	Mg2+ binding site [ion binding]; other site
452863008880	G-X-G motif; other site
452863008881	PspC domain; Region: PspC; pfam04024
452863008882	PspC domain; Region: PspC; pfam04024
452863008883	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
452863008884	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
452863008885	active site
452863008886	ADP/pyrophosphate binding site [chemical binding]; other site
452863008887	dimerization interface [polypeptide binding]; other site
452863008888	allosteric effector site; other site
452863008889	fructose-1,6-bisphosphate binding site; other site
452863008890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863008891	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863008892	putative substrate translocation pore; other site
452863008893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863008894	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
452863008895	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
452863008896	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
452863008897	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
452863008898	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
452863008899	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863008900	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
452863008901	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
452863008902	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
452863008903	heme-binding site [chemical binding]; other site
452863008904	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863008905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863008906	DNA binding site [nucleotide binding]
452863008907	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
452863008908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863008909	Coenzyme A binding pocket [chemical binding]; other site
452863008910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863008911	Coenzyme A binding pocket [chemical binding]; other site
452863008912	polyphosphate kinase; Provisional; Region: PRK05443
452863008913	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
452863008914	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
452863008915	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
452863008916	putative domain interface [polypeptide binding]; other site
452863008917	putative active site [active]
452863008918	catalytic site [active]
452863008919	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
452863008920	putative domain interface [polypeptide binding]; other site
452863008921	putative active site [active]
452863008922	catalytic site [active]
452863008923	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
452863008924	active site
452863008925	Ap6A binding site [chemical binding]; other site
452863008926	nudix motif; other site
452863008927	metal binding site [ion binding]; metal-binding site
452863008928	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863008929	catalytic core [active]
452863008930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863008931	DNA-binding site [nucleotide binding]; DNA binding site
452863008932	thymidylate synthase; Reviewed; Region: thyA; PRK01827
452863008933	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
452863008934	dimerization interface [polypeptide binding]; other site
452863008935	active site
452863008936	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
452863008937	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
452863008938	folate binding site [chemical binding]; other site
452863008939	NADP+ binding site [chemical binding]; other site
452863008940	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
452863008941	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
452863008942	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
452863008943	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
452863008944	FAD binding domain; Region: FAD_binding_4; pfam01565
452863008945	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
452863008946	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
452863008947	active site
452863008948	catalytic site [active]
452863008949	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
452863008950	active site
452863008951	catalytic site [active]
452863008952	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
452863008953	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
452863008954	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
452863008955	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863008956	Predicted transcriptional regulators [Transcription]; Region: COG1733
452863008957	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863008958	dimerization interface [polypeptide binding]; other site
452863008959	putative DNA binding site [nucleotide binding]; other site
452863008960	putative Zn2+ binding site [ion binding]; other site
452863008961	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863008962	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863008963	active site
452863008964	catalytic tetrad [active]
452863008965	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
452863008966	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
452863008967	active site
452863008968	catalytic site [active]
452863008969	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
452863008970	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
452863008971	NADH(P)-binding; Region: NAD_binding_10; pfam13460
452863008972	NAD(P) binding site [chemical binding]; other site
452863008973	putative active site [active]
452863008974	RibD C-terminal domain; Region: RibD_C; cl17279
452863008975	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
452863008976	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
452863008977	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
452863008978	ATP binding site [chemical binding]; other site
452863008979	Mg++ binding site [ion binding]; other site
452863008980	motif III; other site
452863008981	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863008982	nucleotide binding region [chemical binding]; other site
452863008983	ATP-binding site [chemical binding]; other site
452863008984	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
452863008985	putative RNA binding site [nucleotide binding]; other site
452863008986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
452863008987	MOSC domain; Region: MOSC; pfam03473
452863008988	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
452863008989	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
452863008990	acyl-coenzyme A oxidase; Region: PLN02526
452863008991	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
452863008992	active site
452863008993	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748
452863008994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863008995	NAD(P) binding site [chemical binding]; other site
452863008996	active site
452863008997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863008998	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863008999	Predicted transcriptional regulators [Transcription]; Region: COG1733
452863009000	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
452863009001	cystathionine gamma-synthase; Provisional; Region: PRK07811
452863009002	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
452863009003	homodimer interface [polypeptide binding]; other site
452863009004	substrate-cofactor binding pocket; other site
452863009005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863009006	catalytic residue [active]
452863009007	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
452863009008	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
452863009009	dimer interface [polypeptide binding]; other site
452863009010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863009011	catalytic residue [active]
452863009012	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
452863009013	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
452863009014	transmembrane helices; other site
452863009015	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
452863009016	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
452863009017	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863009018	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863009019	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
452863009020	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
452863009021	minor groove reading motif; other site
452863009022	helix-hairpin-helix signature motif; other site
452863009023	active site
452863009024	AMP-binding domain protein; Validated; Region: PRK08315
452863009025	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863009026	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
452863009027	acyl-activating enzyme (AAE) consensus motif; other site
452863009028	acyl-activating enzyme (AAE) consensus motif; other site
452863009029	putative AMP binding site [chemical binding]; other site
452863009030	putative active site [active]
452863009031	putative CoA binding site [chemical binding]; other site
452863009032	Uncharacterized conserved protein [Function unknown]; Region: COG1359
452863009033	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863009034	catalytic residues [active]
452863009035	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863009036	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
452863009037	Walker A/P-loop; other site
452863009038	ATP binding site [chemical binding]; other site
452863009039	Q-loop/lid; other site
452863009040	ABC transporter signature motif; other site
452863009041	Walker B; other site
452863009042	D-loop; other site
452863009043	H-loop/switch region; other site
452863009044	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
452863009045	active site
452863009046	Ion channel; Region: Ion_trans_2; pfam07885
452863009047	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
452863009048	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
452863009049	FOG: CBS domain [General function prediction only]; Region: COG0517
452863009050	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
452863009051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
452863009052	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
452863009053	heat shock protein HtpX; Provisional; Region: PRK03072
452863009054	enterobactin exporter EntS; Provisional; Region: PRK10489
452863009055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863009056	putative substrate translocation pore; other site
452863009057	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
452863009058	metal binding site 2 [ion binding]; metal-binding site
452863009059	putative DNA binding helix; other site
452863009060	metal binding site 1 [ion binding]; metal-binding site
452863009061	dimer interface [polypeptide binding]; other site
452863009062	structural Zn2+ binding site [ion binding]; other site
452863009063	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
452863009064	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
452863009065	tetramer interface [polypeptide binding]; other site
452863009066	heme binding pocket [chemical binding]; other site
452863009067	NADPH binding site [chemical binding]; other site
452863009068	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
452863009069	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863009070	amino acid transporter; Region: 2A0306; TIGR00909
452863009071	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
452863009072	Protein of unknown function (DUF779); Region: DUF779; pfam05610
452863009073	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
452863009074	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
452863009075	NAD binding site [chemical binding]; other site
452863009076	substrate binding site [chemical binding]; other site
452863009077	catalytic Zn binding site [ion binding]; other site
452863009078	tetramer interface [polypeptide binding]; other site
452863009079	structural Zn binding site [ion binding]; other site
452863009080	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
452863009081	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863009082	NAD(P) binding site [chemical binding]; other site
452863009083	catalytic residues [active]
452863009084	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
452863009085	DNA binding site [nucleotide binding]
452863009086	ferredoxin-NADP+ reductase; Region: PLN02852
452863009087	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863009088	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
452863009089	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
452863009090	active site
452863009091	DNA binding site [nucleotide binding]
452863009092	Int/Topo IB signature motif; other site
452863009093	Predicted permeases [General function prediction only]; Region: RarD; COG2962
452863009094	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
452863009095	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863009096	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
452863009097	putative active site [active]
452863009098	putative metal binding site [ion binding]; other site
452863009099	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863009100	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
452863009101	putative active site [active]
452863009102	putative metal binding site [ion binding]; other site
452863009103	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863009104	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
452863009105	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
452863009106	DXD motif; other site
452863009107	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
452863009108	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
452863009109	inhibitor-cofactor binding pocket; inhibition site
452863009110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863009111	catalytic residue [active]
452863009112	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
452863009113	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
452863009114	tetrameric interface [polypeptide binding]; other site
452863009115	NAD binding site [chemical binding]; other site
452863009116	catalytic residues [active]
452863009117	substrate binding site [chemical binding]; other site
452863009118	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
452863009119	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
452863009120	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
452863009121	active site
452863009122	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
452863009123	putative active site; other site
452863009124	putative metal binding residues [ion binding]; other site
452863009125	signature motif; other site
452863009126	putative triphosphate binding site [ion binding]; other site
452863009127	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
452863009128	cyanate transporter; Region: CynX; TIGR00896
452863009129	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863009130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863009131	DNA-binding site [nucleotide binding]; DNA binding site
452863009132	FCD domain; Region: FCD; pfam07729
452863009133	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
452863009134	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
452863009135	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863009136	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863009137	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863009138	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
452863009139	hydrophobic ligand binding site; other site
452863009140	ferredoxin-NADP+ reductase; Region: PLN02852
452863009141	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863009142	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
452863009143	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
452863009144	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
452863009145	active site
452863009146	SAM binding site [chemical binding]; other site
452863009147	homodimer interface [polypeptide binding]; other site
452863009148	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
452863009149	putative hydrophobic ligand binding site [chemical binding]; other site
452863009150	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
452863009151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009152	dimer interface [polypeptide binding]; other site
452863009153	conserved gate region; other site
452863009154	putative PBP binding loops; other site
452863009155	ABC-ATPase subunit interface; other site
452863009156	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
452863009157	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
452863009158	Walker A/P-loop; other site
452863009159	ATP binding site [chemical binding]; other site
452863009160	Q-loop/lid; other site
452863009161	ABC transporter signature motif; other site
452863009162	Walker B; other site
452863009163	D-loop; other site
452863009164	H-loop/switch region; other site
452863009165	NMT1-like family; Region: NMT1_2; pfam13379
452863009166	NMT1/THI5 like; Region: NMT1; pfam09084
452863009167	substrate binding pocket [chemical binding]; other site
452863009168	membrane-bound complex binding site; other site
452863009169	hinge residues; other site
452863009170	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
452863009171	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
452863009172	CysD dimerization site [polypeptide binding]; other site
452863009173	G1 box; other site
452863009174	putative GEF interaction site [polypeptide binding]; other site
452863009175	GTP/Mg2+ binding site [chemical binding]; other site
452863009176	Switch I region; other site
452863009177	G2 box; other site
452863009178	G3 box; other site
452863009179	Switch II region; other site
452863009180	G4 box; other site
452863009181	G5 box; other site
452863009182	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
452863009183	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
452863009184	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
452863009185	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
452863009186	Active Sites [active]
452863009187	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
452863009188	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
452863009189	Active Sites [active]
452863009190	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
452863009191	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
452863009192	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
452863009193	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
452863009194	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
452863009195	putative active site [active]
452863009196	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
452863009197	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
452863009198	putative active site [active]
452863009199	Predicted membrane protein [Function unknown]; Region: COG2860
452863009200	UPF0126 domain; Region: UPF0126; pfam03458
452863009201	UPF0126 domain; Region: UPF0126; pfam03458
452863009202	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863009203	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863009204	putative active site [active]
452863009205	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
452863009206	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
452863009207	substrate binding pocket [chemical binding]; other site
452863009208	chain length determination region; other site
452863009209	substrate-Mg2+ binding site; other site
452863009210	catalytic residues [active]
452863009211	aspartate-rich region 1; other site
452863009212	active site lid residues [active]
452863009213	aspartate-rich region 2; other site
452863009214	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
452863009215	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863009216	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
452863009217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863009218	S-adenosylmethionine binding site [chemical binding]; other site
452863009219	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
452863009220	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863009221	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863009222	substrate binding pocket [chemical binding]; other site
452863009223	membrane-bound complex binding site; other site
452863009224	hinge residues; other site
452863009225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009226	dimer interface [polypeptide binding]; other site
452863009227	conserved gate region; other site
452863009228	putative PBP binding loops; other site
452863009229	ABC-ATPase subunit interface; other site
452863009230	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863009231	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
452863009232	Walker A/P-loop; other site
452863009233	ATP binding site [chemical binding]; other site
452863009234	Q-loop/lid; other site
452863009235	ABC transporter signature motif; other site
452863009236	Walker B; other site
452863009237	D-loop; other site
452863009238	H-loop/switch region; other site
452863009239	aspartate aminotransferase; Provisional; Region: PRK06836
452863009240	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863009241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863009242	homodimer interface [polypeptide binding]; other site
452863009243	catalytic residue [active]
452863009244	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863009245	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863009246	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863009247	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
452863009248	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
452863009249	dimer interface [polypeptide binding]; other site
452863009250	tetramer interface [polypeptide binding]; other site
452863009251	PYR/PP interface [polypeptide binding]; other site
452863009252	TPP binding site [chemical binding]; other site
452863009253	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
452863009254	TPP-binding site; other site
452863009255	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
452863009256	O-succinylbenzoate synthase; Provisional; Region: PRK02901
452863009257	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
452863009258	active site
452863009259	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
452863009260	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
452863009261	oligomer interface [polypeptide binding]; other site
452863009262	metal binding site [ion binding]; metal-binding site
452863009263	metal binding site [ion binding]; metal-binding site
452863009264	putative Cl binding site [ion binding]; other site
452863009265	basic sphincter; other site
452863009266	hydrophobic gate; other site
452863009267	periplasmic entrance; other site
452863009268	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863009269	putative DNA binding site [nucleotide binding]; other site
452863009270	putative Zn2+ binding site [ion binding]; other site
452863009271	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
452863009272	putative hydrophobic ligand binding site [chemical binding]; other site
452863009273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863009274	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
452863009275	active site
452863009276	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
452863009277	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863009278	Catalytic site [active]
452863009279	alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089
452863009280	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863009281	hypothetical protein; Provisional; Region: PRK06185
452863009282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863009283	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863009284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863009285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863009286	putative substrate translocation pore; other site
452863009287	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
452863009288	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
452863009289	PAS domain; Region: PAS_9; pfam13426
452863009290	putative active site [active]
452863009291	heme pocket [chemical binding]; other site
452863009292	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
452863009293	metal binding site [ion binding]; metal-binding site
452863009294	active site
452863009295	I-site; other site
452863009296	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
452863009297	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863009298	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
452863009299	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
452863009300	intersubunit interface [polypeptide binding]; other site
452863009301	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
452863009302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
452863009303	dimer interface [polypeptide binding]; other site
452863009304	putative PBP binding regions; other site
452863009305	ABC-ATPase subunit  interface; other site
452863009306	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863009307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863009308	Walker A/P-loop; other site
452863009309	ATP binding site [chemical binding]; other site
452863009310	Q-loop/lid; other site
452863009311	ABC transporter signature motif; other site
452863009312	Walker B; other site
452863009313	D-loop; other site
452863009314	H-loop/switch region; other site
452863009315	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
452863009316	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
452863009317	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
452863009318	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863009319	Catalytic site [active]
452863009320	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
452863009321	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
452863009322	Multicopper oxidase; Region: Cu-oxidase; pfam00394
452863009323	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
452863009324	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863009325	Interdomain contacts; other site
452863009326	Cytokine receptor motif; other site
452863009327	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
452863009328	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
452863009329	Interdomain contacts; other site
452863009330	Cytokine receptor motif; other site
452863009331	Histidine kinase; Region: HisKA_3; pfam07730
452863009332	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
452863009333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863009334	ATP binding site [chemical binding]; other site
452863009335	Mg2+ binding site [ion binding]; other site
452863009336	G-X-G motif; other site
452863009337	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
452863009338	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
452863009339	DNA binding site [nucleotide binding]
452863009340	Response regulator receiver domain; Region: Response_reg; pfam00072
452863009341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863009342	active site
452863009343	phosphorylation site [posttranslational modification]
452863009344	intermolecular recognition site; other site
452863009345	dimerization interface [polypeptide binding]; other site
452863009346	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863009347	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
452863009348	dimerization interface [polypeptide binding]; other site
452863009349	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863009350	dimer interface [polypeptide binding]; other site
452863009351	phosphorylation site [posttranslational modification]
452863009352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863009353	ATP binding site [chemical binding]; other site
452863009354	Mg2+ binding site [ion binding]; other site
452863009355	G-X-G motif; other site
452863009356	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863009357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863009358	active site
452863009359	phosphorylation site [posttranslational modification]
452863009360	intermolecular recognition site; other site
452863009361	dimerization interface [polypeptide binding]; other site
452863009362	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863009363	DNA binding site [nucleotide binding]
452863009364	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
452863009365	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
452863009366	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
452863009367	heme binding site [chemical binding]; other site
452863009368	substrate binding site [chemical binding]; other site
452863009369	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
452863009370	HipA N-terminal domain; Region: Couple_hipA; pfam13657
452863009371	HipA-like N-terminal domain; Region: HipA_N; pfam07805
452863009372	HipA-like C-terminal domain; Region: HipA_C; pfam07804
452863009373	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863009374	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863009375	sequence-specific DNA binding site [nucleotide binding]; other site
452863009376	salt bridge; other site
452863009377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863009378	NADH(P)-binding; Region: NAD_binding_10; pfam13460
452863009379	NAD(P) binding site [chemical binding]; other site
452863009380	active site
452863009381	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863009382	PAS domain; Region: PAS_9; pfam13426
452863009383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863009384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863009385	dimer interface [polypeptide binding]; other site
452863009386	phosphorylation site [posttranslational modification]
452863009387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863009388	ATP binding site [chemical binding]; other site
452863009389	Mg2+ binding site [ion binding]; other site
452863009390	G-X-G motif; other site
452863009391	Uncharacterized conserved protein [Function unknown]; Region: COG2353
452863009392	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
452863009393	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
452863009394	active site
452863009395	catalytic triad [active]
452863009396	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
452863009397	active site
452863009398	catalytic triad [active]
452863009399	oxyanion hole [active]
452863009400	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
452863009401	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
452863009402	Walker A/P-loop; other site
452863009403	ATP binding site [chemical binding]; other site
452863009404	Q-loop/lid; other site
452863009405	ABC transporter signature motif; other site
452863009406	Walker B; other site
452863009407	D-loop; other site
452863009408	H-loop/switch region; other site
452863009409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863009410	DNA-binding site [nucleotide binding]; DNA binding site
452863009411	putative lipid kinase; Reviewed; Region: PRK13057
452863009412	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863009413	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
452863009414	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863009415	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
452863009416	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863009417	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
452863009418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863009419	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863009420	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863009421	DNA binding site [nucleotide binding]
452863009422	domain linker motif; other site
452863009423	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863009424	putative dimerization interface [polypeptide binding]; other site
452863009425	putative ligand binding site [chemical binding]; other site
452863009426	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
452863009427	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
452863009428	putative substrate binding site [chemical binding]; other site
452863009429	putative ATP binding site [chemical binding]; other site
452863009430	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
452863009431	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
452863009432	substrate binding [chemical binding]; other site
452863009433	active site
452863009434	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
452863009435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863009436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863009437	DNA binding site [nucleotide binding]
452863009438	domain linker motif; other site
452863009439	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863009440	putative dimerization interface [polypeptide binding]; other site
452863009441	putative ligand binding site [chemical binding]; other site
452863009442	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863009443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009444	dimer interface [polypeptide binding]; other site
452863009445	conserved gate region; other site
452863009446	putative PBP binding loops; other site
452863009447	ABC-ATPase subunit interface; other site
452863009448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009449	dimer interface [polypeptide binding]; other site
452863009450	conserved gate region; other site
452863009451	putative PBP binding loops; other site
452863009452	ABC-ATPase subunit interface; other site
452863009453	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009454	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863009455	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
452863009456	E3 interaction surface; other site
452863009457	lipoyl attachment site [posttranslational modification]; other site
452863009458	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
452863009459	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
452863009460	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
452863009461	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
452863009462	alpha subunit interface [polypeptide binding]; other site
452863009463	TPP binding site [chemical binding]; other site
452863009464	heterodimer interface [polypeptide binding]; other site
452863009465	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863009466	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
452863009467	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
452863009468	tetramer interface [polypeptide binding]; other site
452863009469	TPP-binding site [chemical binding]; other site
452863009470	heterodimer interface [polypeptide binding]; other site
452863009471	phosphorylation loop region [posttranslational modification]
452863009472	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863009473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863009474	active site
452863009475	phosphorylation site [posttranslational modification]
452863009476	intermolecular recognition site; other site
452863009477	dimerization interface [polypeptide binding]; other site
452863009478	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863009479	DNA binding site [nucleotide binding]
452863009480	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
452863009481	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
452863009482	active site
452863009483	tetramer interface; other site
452863009484	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
452863009485	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863009486	TM1410 hypothetical-related protein; Region: DUF297; cl00997
452863009487	UDP-glucose 4-epimerase; Region: PLN02240
452863009488	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
452863009489	NAD binding site [chemical binding]; other site
452863009490	homodimer interface [polypeptide binding]; other site
452863009491	active site
452863009492	substrate binding site [chemical binding]; other site
452863009493	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
452863009494	putative binding surface; other site
452863009495	active site
452863009496	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863009497	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
452863009498	putative DNA binding site [nucleotide binding]; other site
452863009499	putative Zn2+ binding site [ion binding]; other site
452863009500	AsnC family; Region: AsnC_trans_reg; pfam01037
452863009501	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
452863009502	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
452863009503	Catalytic site [active]
452863009504	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863009505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863009506	active site
452863009507	phosphorylation site [posttranslational modification]
452863009508	intermolecular recognition site; other site
452863009509	dimerization interface [polypeptide binding]; other site
452863009510	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863009511	DNA binding site [nucleotide binding]
452863009512	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
452863009513	active site
452863009514	oxyanion hole [active]
452863009515	catalytic triad [active]
452863009516	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
452863009517	active site
452863009518	oxyanion hole [active]
452863009519	catalytic triad [active]
452863009520	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
452863009521	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
452863009522	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863009523	DXD motif; other site
452863009524	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
452863009525	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
452863009526	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
452863009527	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863009528	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
452863009529	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
452863009530	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
452863009531	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
452863009532	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
452863009533	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863009534	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
452863009535	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863009536	active site
452863009537	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
452863009538	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
452863009539	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
452863009540	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
452863009541	trimer interface [polypeptide binding]; other site
452863009542	active site
452863009543	substrate binding site [chemical binding]; other site
452863009544	CoA binding site [chemical binding]; other site
452863009545	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
452863009546	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863009547	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
452863009548	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
452863009549	Chain length determinant protein; Region: Wzz; cl15801
452863009550	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
452863009551	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
452863009552	Bacterial sugar transferase; Region: Bac_transf; pfam02397
452863009553	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
452863009554	VanZ like family; Region: VanZ; cl01971
452863009555	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
452863009556	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
452863009557	active site
452863009558	tetramer interface; other site
452863009559	Chain length determinant protein; Region: Wzz; cl15801
452863009560	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
452863009561	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
452863009562	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
452863009563	IPT/TIG domain; Region: TIG; pfam01833
452863009564	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
452863009565	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863009566	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
452863009567	DXD motif; other site
452863009568	enoyl-CoA hydratase; Provisional; Region: PRK08140
452863009569	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863009570	substrate binding site [chemical binding]; other site
452863009571	oxyanion hole (OAH) forming residues; other site
452863009572	trimer interface [polypeptide binding]; other site
452863009573	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
452863009574	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
452863009575	FAD binding pocket [chemical binding]; other site
452863009576	FAD binding motif [chemical binding]; other site
452863009577	phosphate binding motif [ion binding]; other site
452863009578	beta-alpha-beta structure motif; other site
452863009579	NAD(p) ribose binding residues [chemical binding]; other site
452863009580	NAD binding pocket [chemical binding]; other site
452863009581	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
452863009582	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
452863009583	catalytic loop [active]
452863009584	iron binding site [ion binding]; other site
452863009585	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
452863009586	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
452863009587	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
452863009588	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
452863009589	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
452863009590	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
452863009591	Phosphotransferase enzyme family; Region: APH; pfam01636
452863009592	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
452863009593	active site
452863009594	ATP binding site [chemical binding]; other site
452863009595	Protein of unknown function (DUF419); Region: DUF419; pfam04237
452863009596	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
452863009597	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
452863009598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
452863009599	DNA binding residues [nucleotide binding]
452863009600	Global regulator protein family; Region: CsrA; pfam02599
452863009601	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
452863009602	FHIPEP family; Region: FHIPEP; pfam00771
452863009603	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
452863009604	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
452863009605	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
452863009606	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
452863009607	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
452863009608	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
452863009609	flagellar motor switch protein FliN; Region: fliN; TIGR02480
452863009610	Flagellar motor switch protein FliM; Region: FliM; pfam02154
452863009611	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
452863009612	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
452863009613	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
452863009614	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
452863009615	ligand binding site [chemical binding]; other site
452863009616	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
452863009617	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
452863009618	Flagellar protein (FlbD); Region: FlbD; pfam06289
452863009619	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
452863009620	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
452863009621	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
452863009622	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
452863009623	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
452863009624	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
452863009625	NlpC/P60 family; Region: NLPC_P60; pfam00877
452863009626	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
452863009627	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
452863009628	Walker A motif/ATP binding site; other site
452863009629	Walker B motif; other site
452863009630	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
452863009631	FliG C-terminal domain; Region: FliG_C; pfam01706
452863009632	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
452863009633	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
452863009634	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
452863009635	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
452863009636	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
452863009637	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
452863009638	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
452863009639	Flagellar protein FliS; Region: FliS; cl00654
452863009640	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
452863009641	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
452863009642	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
452863009643	flagellin; Reviewed; Region: PRK08869
452863009644	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
452863009645	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
452863009646	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
452863009647	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
452863009648	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
452863009649	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
452863009650	FliW protein; Region: FliW; cl00740
452863009651	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
452863009652	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
452863009653	Walker A/P-loop; other site
452863009654	ATP binding site [chemical binding]; other site
452863009655	Q-loop/lid; other site
452863009656	ABC transporter signature motif; other site
452863009657	Walker B; other site
452863009658	D-loop; other site
452863009659	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
452863009660	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
452863009661	siderophore binding site; other site
452863009662	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
452863009663	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
452863009664	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
452863009665	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
452863009666	dimer interface [polypeptide binding]; other site
452863009667	putative PBP binding regions; other site
452863009668	ABC-ATPase subunit  interface; other site
452863009669	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863009670	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863009671	salt bridge; other site
452863009672	non-specific DNA binding site [nucleotide binding]; other site
452863009673	sequence-specific DNA binding site [nucleotide binding]; other site
452863009674	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863009675	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863009676	active site
452863009677	catalytic tetrad [active]
452863009678	short chain dehydrogenase; Provisional; Region: PRK06180
452863009679	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
452863009680	NADP binding site [chemical binding]; other site
452863009681	active site
452863009682	steroid binding site; other site
452863009683	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
452863009684	Predicted transcriptional regulators [Transcription]; Region: COG1695
452863009685	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
452863009686	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
452863009687	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863009688	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863009689	Walker A/P-loop; other site
452863009690	ATP binding site [chemical binding]; other site
452863009691	Q-loop/lid; other site
452863009692	ABC transporter signature motif; other site
452863009693	Walker B; other site
452863009694	D-loop; other site
452863009695	H-loop/switch region; other site
452863009696	ABC-2 type transporter; Region: ABC2_membrane; cl17235
452863009697	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
452863009698	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
452863009699	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863009700	carboxylate-amine ligase; Provisional; Region: PRK13517
452863009701	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
452863009702	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
452863009703	GAF domain; Region: GAF; cl17456
452863009704	GAF domain; Region: GAF_2; pfam13185
452863009705	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863009706	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
452863009707	Chromate transporter; Region: Chromate_transp; pfam02417
452863009708	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
452863009709	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863009710	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863009711	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
452863009712	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863009713	PAS fold; Region: PAS_3; pfam08447
452863009714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
452863009715	putative active site [active]
452863009716	heme pocket [chemical binding]; other site
452863009717	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863009718	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
452863009719	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
452863009720	Soluble P-type ATPase [General function prediction only]; Region: COG4087
452863009721	Domain of unknown function (DUF305); Region: DUF305; pfam03713
452863009722	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
452863009723	Low molecular weight phosphatase family; Region: LMWPc; cl00105
452863009724	active site
452863009725	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
452863009726	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
452863009727	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
452863009728	putative active site [active]
452863009729	putative metal binding site [ion binding]; other site
452863009730	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
452863009731	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863009732	catalytic core [active]
452863009733	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
452863009734	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
452863009735	ATP binding site [chemical binding]; other site
452863009736	substrate binding site [chemical binding]; other site
452863009737	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
452863009738	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
452863009739	putative dimer interface [polypeptide binding]; other site
452863009740	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
452863009741	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
452863009742	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
452863009743	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
452863009744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863009745	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
452863009746	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863009747	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
452863009748	propionate/acetate kinase; Provisional; Region: PRK12379
452863009749	phosphate acetyltransferase; Reviewed; Region: PRK05632
452863009750	DRTGG domain; Region: DRTGG; pfam07085
452863009751	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
452863009752	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
452863009753	CoenzymeA binding site [chemical binding]; other site
452863009754	subunit interaction site [polypeptide binding]; other site
452863009755	PHB binding site; other site
452863009756	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863009757	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
452863009758	acyl-activating enzyme (AAE) consensus motif; other site
452863009759	AMP binding site [chemical binding]; other site
452863009760	active site
452863009761	CoA binding site [chemical binding]; other site
452863009762	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863009763	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863009764	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863009765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863009766	active site
452863009767	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
452863009768	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
452863009769	substrate binding site [chemical binding]; other site
452863009770	dimer interface [polypeptide binding]; other site
452863009771	NADP binding site [chemical binding]; other site
452863009772	catalytic residues [active]
452863009773	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
452863009774	active site 2 [active]
452863009775	active site 1 [active]
452863009776	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
452863009777	CoenzymeA binding site [chemical binding]; other site
452863009778	subunit interaction site [polypeptide binding]; other site
452863009779	PHB binding site; other site
452863009780	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
452863009781	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
452863009782	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
452863009783	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
452863009784	active site
452863009785	catalytic triad [active]
452863009786	oxyanion hole [active]
452863009787	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
452863009788	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
452863009789	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
452863009790	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
452863009791	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
452863009792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863009793	substrate binding site [chemical binding]; other site
452863009794	oxyanion hole (OAH) forming residues; other site
452863009795	trimer interface [polypeptide binding]; other site
452863009796	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
452863009797	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863009798	dimer interface [polypeptide binding]; other site
452863009799	active site
452863009800	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
452863009801	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
452863009802	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
452863009803	hydrophobic ligand binding site; other site
452863009804	CsbD-like; Region: CsbD; pfam05532
452863009805	DNA polymerase IV; Validated; Region: PRK03352
452863009806	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
452863009807	active site
452863009808	DNA binding site [nucleotide binding]
452863009809	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
452863009810	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
452863009811	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
452863009812	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
452863009813	CAAX protease self-immunity; Region: Abi; pfam02517
452863009814	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863009815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009816	dimer interface [polypeptide binding]; other site
452863009817	conserved gate region; other site
452863009818	putative PBP binding loops; other site
452863009819	ABC-ATPase subunit interface; other site
452863009820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009821	dimer interface [polypeptide binding]; other site
452863009822	conserved gate region; other site
452863009823	putative PBP binding loops; other site
452863009824	ABC-ATPase subunit interface; other site
452863009825	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863009826	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009827	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
452863009828	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863009829	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
452863009830	substrate binding site [chemical binding]; other site
452863009831	oxyanion hole (OAH) forming residues; other site
452863009832	trimer interface [polypeptide binding]; other site
452863009833	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
452863009834	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
452863009835	acyl-activating enzyme (AAE) consensus motif; other site
452863009836	active site
452863009837	AMP binding site [chemical binding]; other site
452863009838	CoA binding site [chemical binding]; other site
452863009839	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
452863009840	UbiA prenyltransferase family; Region: UbiA; pfam01040
452863009841	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
452863009842	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
452863009843	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
452863009844	Dynamin family; Region: Dynamin_N; pfam00350
452863009845	G1 box; other site
452863009846	GTP/Mg2+ binding site [chemical binding]; other site
452863009847	G2 box; other site
452863009848	Switch I region; other site
452863009849	G3 box; other site
452863009850	Switch II region; other site
452863009851	G4 box; other site
452863009852	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
452863009853	Dynamin family; Region: Dynamin_N; pfam00350
452863009854	G1 box; other site
452863009855	GTP/Mg2+ binding site [chemical binding]; other site
452863009856	G2 box; other site
452863009857	Switch I region; other site
452863009858	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
452863009859	G3 box; other site
452863009860	Switch II region; other site
452863009861	GTP/Mg2+ binding site [chemical binding]; other site
452863009862	G4 box; other site
452863009863	G5 box; other site
452863009864	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863009865	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863009866	DNA binding residues [nucleotide binding]
452863009867	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
452863009868	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
452863009869	nucleotide binding site [chemical binding]; other site
452863009870	putative NEF/HSP70 interaction site [polypeptide binding]; other site
452863009871	SBD interface [polypeptide binding]; other site
452863009872	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
452863009873	ResB-like family; Region: ResB; pfam05140
452863009874	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
452863009875	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
452863009876	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
452863009877	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
452863009878	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
452863009879	catalytic residues [active]
452863009880	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863009881	catalytic core [active]
452863009882	Uncharacterized conserved protein [Function unknown]; Region: COG2353
452863009883	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
452863009884	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
452863009885	CoA binding domain; Region: CoA_binding; pfam02629
452863009886	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
452863009887	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
452863009888	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
452863009889	DNA binding domain, excisionase family; Region: excise; TIGR01764
452863009890	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
452863009891	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
452863009892	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
452863009893	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
452863009894	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
452863009895	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
452863009896	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
452863009897	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
452863009898	Cysteine-rich domain; Region: CCG; pfam02754
452863009899	Cysteine-rich domain; Region: CCG; pfam02754
452863009900	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
452863009901	N- and C-terminal domain interface [polypeptide binding]; other site
452863009902	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
452863009903	active site
452863009904	putative catalytic site [active]
452863009905	metal binding site [ion binding]; metal-binding site
452863009906	ATP binding site [chemical binding]; other site
452863009907	carbohydrate binding site [chemical binding]; other site
452863009908	short chain dehydrogenase; Validated; Region: PRK08324
452863009909	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
452863009910	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
452863009911	putative NAD(P) binding site [chemical binding]; other site
452863009912	active site
452863009913	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
452863009914	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
452863009915	Domain of unknown function (DUF718); Region: DUF718; pfam05336
452863009916	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863009917	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863009918	DNA binding site [nucleotide binding]
452863009919	domain linker motif; other site
452863009920	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863009921	dimerization interface [polypeptide binding]; other site
452863009922	ligand binding site [chemical binding]; other site
452863009923	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
452863009924	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
452863009925	active site
452863009926	catalytic triad [active]
452863009927	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863009928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009929	dimer interface [polypeptide binding]; other site
452863009930	conserved gate region; other site
452863009931	putative PBP binding loops; other site
452863009932	ABC-ATPase subunit interface; other site
452863009933	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863009934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009935	dimer interface [polypeptide binding]; other site
452863009936	conserved gate region; other site
452863009937	ABC-ATPase subunit interface; other site
452863009938	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863009939	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009940	Protein of unknown function, DUF624; Region: DUF624; cl02369
452863009941	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863009942	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863009943	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
452863009944	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
452863009945	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009946	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863009947	Transmembrane secretion effector; Region: MFS_3; pfam05977
452863009948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863009949	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863009950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009951	dimer interface [polypeptide binding]; other site
452863009952	conserved gate region; other site
452863009953	putative PBP binding loops; other site
452863009954	ABC-ATPase subunit interface; other site
452863009955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009956	dimer interface [polypeptide binding]; other site
452863009957	putative PBP binding loops; other site
452863009958	ABC-ATPase subunit interface; other site
452863009959	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863009960	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009961	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
452863009962	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
452863009963	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
452863009964	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
452863009965	Domain of unknown function (DUF222); Region: DUF222; pfam02720
452863009966	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863009967	active site
452863009968	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863009969	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009970	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863009971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009972	dimer interface [polypeptide binding]; other site
452863009973	conserved gate region; other site
452863009974	putative PBP binding loops; other site
452863009975	ABC-ATPase subunit interface; other site
452863009976	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863009977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863009978	dimer interface [polypeptide binding]; other site
452863009979	putative PBP binding loops; other site
452863009980	ABC-ATPase subunit interface; other site
452863009981	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863009982	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863009983	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863009984	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863009985	Methane oxygenase PmoA; Region: PmoA; pfam14100
452863009986	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
452863009987	active site
452863009988	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
452863009989	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
452863009990	dimer interface [polypeptide binding]; other site
452863009991	NADP binding site [chemical binding]; other site
452863009992	catalytic residues [active]
452863009993	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
452863009994	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
452863009995	active site pocket [active]
452863009996	5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
452863009997	catalytic residue [active]
452863009998	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863009999	extended (e) SDRs; Region: SDR_e; cd08946
452863010000	NAD(P) binding site [chemical binding]; other site
452863010001	active site
452863010002	substrate binding site [chemical binding]; other site
452863010003	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863010004	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863010005	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863010006	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863010007	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863010008	DNA binding site [nucleotide binding]
452863010009	domain linker motif; other site
452863010010	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863010011	dimerization interface [polypeptide binding]; other site
452863010012	ligand binding site [chemical binding]; other site
452863010013	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
452863010014	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
452863010015	phosphate binding site [ion binding]; other site
452863010016	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863010017	dimerization interface [polypeptide binding]; other site
452863010018	putative DNA binding site [nucleotide binding]; other site
452863010019	putative Zn2+ binding site [ion binding]; other site
452863010020	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
452863010021	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
452863010022	active site
452863010023	Zn binding site [ion binding]; other site
452863010024	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
452863010025	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
452863010026	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
452863010027	TrkA-N domain; Region: TrkA_N; pfam02254
452863010028	TrkA-C domain; Region: TrkA_C; pfam02080
452863010029	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
452863010030	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
452863010031	exopolyphosphatase; Region: exo_poly_only; TIGR03706
452863010032	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
452863010033	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
452863010034	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
452863010035	active site
452863010036	interdomain interaction site; other site
452863010037	putative metal-binding site [ion binding]; other site
452863010038	nucleotide binding site [chemical binding]; other site
452863010039	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
452863010040	domain I; other site
452863010041	phosphate binding site [ion binding]; other site
452863010042	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
452863010043	domain II; other site
452863010044	domain III; other site
452863010045	nucleotide binding site [chemical binding]; other site
452863010046	DNA binding groove [nucleotide binding]
452863010047	catalytic site [active]
452863010048	domain IV; other site
452863010049	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
452863010050	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
452863010051	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
452863010052	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
452863010053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863010054	S-adenosylmethionine binding site [chemical binding]; other site
452863010055	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
452863010056	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
452863010057	active site residue [active]
452863010058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863010059	Coenzyme A binding pocket [chemical binding]; other site
452863010060	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
452863010061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863010062	ATP binding site [chemical binding]; other site
452863010063	putative Mg++ binding site [ion binding]; other site
452863010064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863010065	nucleotide binding region [chemical binding]; other site
452863010066	ATP-binding site [chemical binding]; other site
452863010067	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
452863010068	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
452863010069	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
452863010070	Type II/IV secretion system protein; Region: T2SE; pfam00437
452863010071	Walker A motif; other site
452863010072	ATP binding site [chemical binding]; other site
452863010073	Walker B motif; other site
452863010074	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
452863010075	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
452863010076	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
452863010077	active site
452863010078	DNA binding site [nucleotide binding]
452863010079	catalytic site [active]
452863010080	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
452863010081	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
452863010082	putative active site [active]
452863010083	putative CoA binding site [chemical binding]; other site
452863010084	nudix motif; other site
452863010085	metal binding site [ion binding]; metal-binding site
452863010086	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
452863010087	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
452863010088	minor groove reading motif; other site
452863010089	helix-hairpin-helix signature motif; other site
452863010090	substrate binding pocket [chemical binding]; other site
452863010091	active site
452863010092	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
452863010093	acetyl-CoA synthetase; Provisional; Region: PRK00174
452863010094	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
452863010095	active site
452863010096	CoA binding site [chemical binding]; other site
452863010097	acyl-activating enzyme (AAE) consensus motif; other site
452863010098	AMP binding site [chemical binding]; other site
452863010099	acetate binding site [chemical binding]; other site
452863010100	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863010101	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863010102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010103	dimer interface [polypeptide binding]; other site
452863010104	conserved gate region; other site
452863010105	putative PBP binding loops; other site
452863010106	ABC-ATPase subunit interface; other site
452863010107	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863010108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010109	dimer interface [polypeptide binding]; other site
452863010110	conserved gate region; other site
452863010111	putative PBP binding loops; other site
452863010112	ABC-ATPase subunit interface; other site
452863010113	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
452863010114	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
452863010115	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
452863010116	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863010117	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863010118	DNA binding site [nucleotide binding]
452863010119	domain linker motif; other site
452863010120	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863010121	dimerization interface [polypeptide binding]; other site
452863010122	ligand binding site [chemical binding]; other site
452863010123	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
452863010124	Dehydroquinase class II; Region: DHquinase_II; pfam01220
452863010125	trimer interface [polypeptide binding]; other site
452863010126	active site
452863010127	dimer interface [polypeptide binding]; other site
452863010128	Colicin V production protein; Region: Colicin_V; pfam02674
452863010129	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
452863010130	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
452863010131	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
452863010132	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
452863010133	ligand binding site [chemical binding]; other site
452863010134	flexible hinge region; other site
452863010135	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
452863010136	putative switch regulator; other site
452863010137	non-specific DNA interactions [nucleotide binding]; other site
452863010138	DNA binding site [nucleotide binding]
452863010139	sequence specific DNA binding site [nucleotide binding]; other site
452863010140	putative cAMP binding site [chemical binding]; other site
452863010141	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
452863010142	homotrimer interaction site [polypeptide binding]; other site
452863010143	putative active site [active]
452863010144	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
452863010145	Transglycosylase; Region: Transgly; pfam00912
452863010146	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
452863010147	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
452863010148	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
452863010149	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
452863010150	putative active site [active]
452863010151	putative metal binding site [ion binding]; other site
452863010152	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863010153	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863010154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010155	Walker A/P-loop; other site
452863010156	ATP binding site [chemical binding]; other site
452863010157	Q-loop/lid; other site
452863010158	ABC transporter signature motif; other site
452863010159	Walker B; other site
452863010160	D-loop; other site
452863010161	H-loop/switch region; other site
452863010162	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863010163	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863010164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010165	Walker A/P-loop; other site
452863010166	ATP binding site [chemical binding]; other site
452863010167	Q-loop/lid; other site
452863010168	ABC transporter signature motif; other site
452863010169	Walker B; other site
452863010170	D-loop; other site
452863010171	H-loop/switch region; other site
452863010172	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863010173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863010174	non-specific DNA binding site [nucleotide binding]; other site
452863010175	salt bridge; other site
452863010176	sequence-specific DNA binding site [nucleotide binding]; other site
452863010177	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
452863010178	ATP binding site [chemical binding]; other site
452863010179	active site
452863010180	substrate binding site [chemical binding]; other site
452863010181	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
452863010182	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
452863010183	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
452863010184	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
452863010185	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
452863010186	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
452863010187	Moco binding site; other site
452863010188	metal coordination site [ion binding]; other site
452863010189	L-asparaginase II; Region: Asparaginase_II; pfam06089
452863010190	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
452863010191	classical (c) SDRs; Region: SDR_c; cd05233
452863010192	NAD(P) binding site [chemical binding]; other site
452863010193	active site
452863010194	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
452863010195	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
452863010196	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
452863010197	Na binding site [ion binding]; other site
452863010198	putative substrate binding site [chemical binding]; other site
452863010199	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
452863010200	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
452863010201	dimer interface [polypeptide binding]; other site
452863010202	TPP-binding site [chemical binding]; other site
452863010203	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
452863010204	metal-binding site
452863010205	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
452863010206	ligand binding site [chemical binding]; other site
452863010207	active site
452863010208	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863010209	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863010210	active site
452863010211	catalytic tetrad [active]
452863010212	LssY C-terminus; Region: LssY_C; pfam14067
452863010213	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
452863010214	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
452863010215	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
452863010216	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
452863010217	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
452863010218	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
452863010219	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
452863010220	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
452863010221	XdhC Rossmann domain; Region: XdhC_C; pfam13478
452863010222	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
452863010223	benzoate transporter; Region: benE; TIGR00843
452863010224	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
452863010225	nucleoside/Zn binding site; other site
452863010226	dimer interface [polypeptide binding]; other site
452863010227	catalytic motif [active]
452863010228	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
452863010229	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
452863010230	active site
452863010231	putative substrate binding pocket [chemical binding]; other site
452863010232	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
452863010233	nucleotide binding site [chemical binding]; other site
452863010234	urate oxidase; Region: urate_oxi; TIGR03383
452863010235	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
452863010236	active site
452863010237	xanthine permease; Region: pbuX; TIGR03173
452863010238	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863010239	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863010240	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863010241	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
452863010242	Malic enzyme, N-terminal domain; Region: malic; pfam00390
452863010243	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
452863010244	putative NAD(P) binding site [chemical binding]; other site
452863010245	malate synthase A; Region: malate_syn_A; TIGR01344
452863010246	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
452863010247	active site
452863010248	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
452863010249	hypothetical protein; Provisional; Region: PRK11171
452863010250	Cupin domain; Region: Cupin_2; pfam07883
452863010251	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
452863010252	Beta-lactamase; Region: Beta-lactamase; pfam00144
452863010253	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
452863010254	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
452863010255	NAD binding site [chemical binding]; other site
452863010256	catalytic Zn binding site [ion binding]; other site
452863010257	structural Zn binding site [ion binding]; other site
452863010258	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
452863010259	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
452863010260	active site
452863010261	motif I; other site
452863010262	motif II; other site
452863010263	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
452863010264	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
452863010265	Protein of unknown function DUF72; Region: DUF72; pfam01904
452863010266	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
452863010267	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863010268	active site
452863010269	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
452863010270	putative metal binding residues [ion binding]; other site
452863010271	signature motif; other site
452863010272	dimer interface [polypeptide binding]; other site
452863010273	active site
452863010274	polyP binding site; other site
452863010275	substrate binding site [chemical binding]; other site
452863010276	acceptor-phosphate pocket; other site
452863010277	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
452863010278	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
452863010279	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
452863010280	TAP-like protein; Region: Abhydrolase_4; pfam08386
452863010281	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
452863010282	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
452863010283	putative di-iron ligands [ion binding]; other site
452863010284	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
452863010285	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
452863010286	FAD binding pocket [chemical binding]; other site
452863010287	FAD binding motif [chemical binding]; other site
452863010288	phosphate binding motif [ion binding]; other site
452863010289	beta-alpha-beta structure motif; other site
452863010290	NAD binding pocket [chemical binding]; other site
452863010291	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
452863010292	catalytic loop [active]
452863010293	iron binding site [ion binding]; other site
452863010294	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863010295	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863010296	hypothetical protein; Provisional; Region: PRK02237
452863010297	Predicted dehydrogenase [General function prediction only]; Region: COG0579
452863010298	hydroxyglutarate oxidase; Provisional; Region: PRK11728
452863010299	Domain of unknown function (DUF202); Region: DUF202; cl09954
452863010300	Domain of unknown function (DUF202); Region: DUF202; pfam02656
452863010301	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
452863010302	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
452863010303	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863010304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010305	putative substrate translocation pore; other site
452863010306	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863010307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
452863010308	DNA-binding site [nucleotide binding]; DNA binding site
452863010309	FCD domain; Region: FCD; pfam07729
452863010310	Predicted amidohydrolase [General function prediction only]; Region: COG0388
452863010311	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
452863010312	putative active site [active]
452863010313	catalytic triad [active]
452863010314	putative dimer interface [polypeptide binding]; other site
452863010315	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
452863010316	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863010317	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
452863010318	catalytic site [active]
452863010319	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
452863010320	Predicted transcriptional regulators [Transcription]; Region: COG1695
452863010321	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863010322	putative DNA binding site [nucleotide binding]; other site
452863010323	putative Zn2+ binding site [ion binding]; other site
452863010324	Transglycosylase; Region: Transgly; pfam00912
452863010325	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
452863010326	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
452863010327	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863010328	active site
452863010329	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863010330	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863010331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863010332	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
452863010333	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
452863010334	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
452863010335	putative hydrophobic ligand binding site [chemical binding]; other site
452863010336	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863010337	dimerization interface [polypeptide binding]; other site
452863010338	putative DNA binding site [nucleotide binding]; other site
452863010339	putative Zn2+ binding site [ion binding]; other site
452863010340	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
452863010341	proposed catalytic triad [active]
452863010342	active site nucleophile [active]
452863010343	GAF domain; Region: GAF_2; pfam13185
452863010344	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
452863010345	Asp23 family; Region: Asp23; pfam03780
452863010346	CsbD-like; Region: CsbD; pfam05532
452863010347	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
452863010348	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863010349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863010350	DNA binding residues [nucleotide binding]
452863010351	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863010352	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863010353	DNA binding site [nucleotide binding]
452863010354	domain linker motif; other site
452863010355	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863010356	putative dimerization interface [polypeptide binding]; other site
452863010357	putative ligand binding site [chemical binding]; other site
452863010358	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
452863010359	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
452863010360	substrate binding [chemical binding]; other site
452863010361	active site
452863010362	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863010363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010364	dimer interface [polypeptide binding]; other site
452863010365	conserved gate region; other site
452863010366	putative PBP binding loops; other site
452863010367	ABC-ATPase subunit interface; other site
452863010368	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863010369	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
452863010370	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863010371	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863010372	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
452863010373	active site
452863010374	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
452863010375	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
452863010376	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
452863010377	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
452863010378	putative NAD(P) binding site [chemical binding]; other site
452863010379	putative substrate binding site [chemical binding]; other site
452863010380	catalytic Zn binding site [ion binding]; other site
452863010381	structural Zn binding site [ion binding]; other site
452863010382	dimer interface [polypeptide binding]; other site
452863010383	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
452863010384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863010385	salt bridge; other site
452863010386	non-specific DNA binding site [nucleotide binding]; other site
452863010387	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863010388	sequence-specific DNA binding site [nucleotide binding]; other site
452863010389	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
452863010390	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
452863010391	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
452863010392	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
452863010393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
452863010394	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
452863010395	putative PBP binding loops; other site
452863010396	dimer interface [polypeptide binding]; other site
452863010397	ABC-ATPase subunit interface; other site
452863010398	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
452863010399	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
452863010400	Walker A/P-loop; other site
452863010401	ATP binding site [chemical binding]; other site
452863010402	Q-loop/lid; other site
452863010403	ABC transporter signature motif; other site
452863010404	Walker B; other site
452863010405	D-loop; other site
452863010406	H-loop/switch region; other site
452863010407	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
452863010408	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
452863010409	active site
452863010410	non-prolyl cis peptide bond; other site
452863010411	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
452863010412	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
452863010413	active site
452863010414	non-prolyl cis peptide bond; other site
452863010415	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863010416	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863010417	active site
452863010418	catalytic tetrad [active]
452863010419	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863010420	Ligand Binding Site [chemical binding]; other site
452863010421	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
452863010422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010423	putative substrate translocation pore; other site
452863010424	Protein of unknown function (DUF817); Region: DUF817; pfam05675
452863010425	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
452863010426	Hpt domain; Region: Hpt; pfam01627
452863010427	putative binding surface; other site
452863010428	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863010429	Coenzyme A binding pocket [chemical binding]; other site
452863010430	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
452863010431	PAS fold; Region: PAS_3; pfam08447
452863010432	putative active site [active]
452863010433	heme pocket [chemical binding]; other site
452863010434	ANTAR domain; Region: ANTAR; pfam03861
452863010435	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
452863010436	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
452863010437	active site
452863010438	catalytic site [active]
452863010439	Zn binding site [ion binding]; other site
452863010440	tetramer interface [polypeptide binding]; other site
452863010441	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
452863010442	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
452863010443	Na binding site [ion binding]; other site
452863010444	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
452863010445	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
452863010446	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
452863010447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863010448	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
452863010449	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863010450	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863010451	putative Zn2+ binding site [ion binding]; other site
452863010452	putative DNA binding site [nucleotide binding]; other site
452863010453	dimerization interface [polypeptide binding]; other site
452863010454	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863010455	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
452863010456	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
452863010457	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
452863010458	active site
452863010459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010460	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863010461	putative substrate translocation pore; other site
452863010462	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
452863010463	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863010464	NAD(P) binding site [chemical binding]; other site
452863010465	catalytic residues [active]
452863010466	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863010467	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863010468	NAD(P) binding site [chemical binding]; other site
452863010469	active site
452863010470	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
452863010471	inhibitor site; inhibition site
452863010472	active site
452863010473	dimer interface [polypeptide binding]; other site
452863010474	catalytic residue [active]
452863010475	enoyl-CoA hydratase; Provisional; Region: PRK06494
452863010476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
452863010477	substrate binding site [chemical binding]; other site
452863010478	oxyanion hole (OAH) forming residues; other site
452863010479	trimer interface [polypeptide binding]; other site
452863010480	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
452863010481	CoA-transferase family III; Region: CoA_transf_3; pfam02515
452863010482	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
452863010483	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863010484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010485	putative substrate translocation pore; other site
452863010486	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
452863010487	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863010488	non-specific DNA binding site [nucleotide binding]; other site
452863010489	salt bridge; other site
452863010490	sequence-specific DNA binding site [nucleotide binding]; other site
452863010491	Cupin domain; Region: Cupin_2; pfam07883
452863010492	lipoprotein LpqB; Provisional; Region: PRK13616
452863010493	Cation efflux family; Region: Cation_efflux; cl00316
452863010494	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863010495	putative DNA binding site [nucleotide binding]; other site
452863010496	Transcriptional regulators [Transcription]; Region: MarR; COG1846
452863010497	putative Zn2+ binding site [ion binding]; other site
452863010498	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
452863010499	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
452863010500	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
452863010501	dimer interface [polypeptide binding]; other site
452863010502	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863010503	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863010504	active site
452863010505	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
452863010506	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863010507	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
452863010508	Patatin-like phospholipase; Region: Patatin; pfam01734
452863010509	active site
452863010510	nucleophile elbow; other site
452863010511	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
452863010512	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
452863010513	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
452863010514	putative active site [active]
452863010515	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
452863010516	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863010517	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863010518	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863010519	NAD(P) binding site [chemical binding]; other site
452863010520	catalytic residues [active]
452863010521	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
452863010522	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
452863010523	metal binding site [ion binding]; metal-binding site
452863010524	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
452863010525	Flavodoxin domain; Region: Flavodoxin_5; cl17428
452863010526	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863010527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863010528	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
452863010529	putative dimerization interface [polypeptide binding]; other site
452863010530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
452863010531	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
452863010532	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
452863010533	BCCT family transporter; Region: BCCT; pfam02028
452863010534	Cobalt transport protein; Region: CbiQ; cl00463
452863010535	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
452863010536	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863010537	Walker A/P-loop; other site
452863010538	ATP binding site [chemical binding]; other site
452863010539	Q-loop/lid; other site
452863010540	ABC transporter signature motif; other site
452863010541	Walker B; other site
452863010542	D-loop; other site
452863010543	H-loop/switch region; other site
452863010544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010545	Walker A/P-loop; other site
452863010546	ATP binding site [chemical binding]; other site
452863010547	Q-loop/lid; other site
452863010548	ABC transporter signature motif; other site
452863010549	Walker B; other site
452863010550	D-loop; other site
452863010551	H-loop/switch region; other site
452863010552	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
452863010553	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
452863010554	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
452863010555	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863010556	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
452863010557	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
452863010558	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
452863010559	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
452863010560	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
452863010561	substrate binding pocket [chemical binding]; other site
452863010562	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
452863010563	B12 binding site [chemical binding]; other site
452863010564	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
452863010565	Uncharacterized conserved protein [Function unknown]; Region: COG4748
452863010566	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
452863010567	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
452863010568	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863010569	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
452863010570	Walker A/P-loop; other site
452863010571	ATP binding site [chemical binding]; other site
452863010572	Q-loop/lid; other site
452863010573	ABC transporter signature motif; other site
452863010574	Walker B; other site
452863010575	D-loop; other site
452863010576	H-loop/switch region; other site
452863010577	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
452863010578	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
452863010579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010580	Walker A/P-loop; other site
452863010581	ATP binding site [chemical binding]; other site
452863010582	Q-loop/lid; other site
452863010583	ABC transporter signature motif; other site
452863010584	Walker B; other site
452863010585	D-loop; other site
452863010586	H-loop/switch region; other site
452863010587	benzoate transport; Region: 2A0115; TIGR00895
452863010588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010589	putative substrate translocation pore; other site
452863010590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010591	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
452863010592	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
452863010593	active site
452863010594	hypothetical protein; Provisional; Region: PRK09262
452863010595	Amidohydrolase; Region: Amidohydro_2; pfam04909
452863010596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
452863010597	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863010598	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863010599	DNA-binding site [nucleotide binding]; DNA binding site
452863010600	FCD domain; Region: FCD; pfam07729
452863010601	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
452863010602	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
452863010603	NAD(P) binding site [chemical binding]; other site
452863010604	active site
452863010605	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
452863010606	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
452863010607	dimer interface [polypeptide binding]; other site
452863010608	active site
452863010609	heme binding site [chemical binding]; other site
452863010610	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
452863010611	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863010612	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863010613	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863010614	salt bridge; other site
452863010615	non-specific DNA binding site [nucleotide binding]; other site
452863010616	sequence-specific DNA binding site [nucleotide binding]; other site
452863010617	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
452863010618	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
452863010619	short chain dehydrogenase; Provisional; Region: PRK08219
452863010620	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863010621	NAD(P) binding site [chemical binding]; other site
452863010622	active site
452863010623	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
452863010624	active site
452863010625	catalytic triad [active]
452863010626	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863010627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010628	putative substrate translocation pore; other site
452863010629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863010630	salt bridge; other site
452863010631	non-specific DNA binding site [nucleotide binding]; other site
452863010632	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863010633	sequence-specific DNA binding site [nucleotide binding]; other site
452863010634	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
452863010635	putative dimer interface [polypeptide binding]; other site
452863010636	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863010637	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863010638	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863010639	DNA binding site [nucleotide binding]
452863010640	domain linker motif; other site
452863010641	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
452863010642	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
452863010643	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
452863010644	inhibitor site; inhibition site
452863010645	active site
452863010646	dimer interface [polypeptide binding]; other site
452863010647	catalytic residue [active]
452863010648	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
452863010649	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
452863010650	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863010651	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863010652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863010653	active site
452863010654	phosphorylation site [posttranslational modification]
452863010655	intermolecular recognition site; other site
452863010656	dimerization interface [polypeptide binding]; other site
452863010657	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863010658	DNA binding residues [nucleotide binding]
452863010659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
452863010660	Histidine kinase; Region: HisKA_3; pfam07730
452863010661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
452863010662	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
452863010663	FtsX-like permease family; Region: FtsX; pfam02687
452863010664	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
452863010665	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
452863010666	Walker A/P-loop; other site
452863010667	ATP binding site [chemical binding]; other site
452863010668	Q-loop/lid; other site
452863010669	ABC transporter signature motif; other site
452863010670	Walker B; other site
452863010671	D-loop; other site
452863010672	H-loop/switch region; other site
452863010673	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
452863010674	catalytic site [active]
452863010675	BNR repeat-like domain; Region: BNR_2; pfam13088
452863010676	Asp-box motif; other site
452863010677	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
452863010678	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
452863010679	catalytic site [active]
452863010680	BNR repeat-like domain; Region: BNR_2; pfam13088
452863010681	Asp-box motif; other site
452863010682	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
452863010683	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
452863010684	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863010685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010686	dimer interface [polypeptide binding]; other site
452863010687	conserved gate region; other site
452863010688	putative PBP binding loops; other site
452863010689	ABC-ATPase subunit interface; other site
452863010690	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
452863010691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010692	dimer interface [polypeptide binding]; other site
452863010693	conserved gate region; other site
452863010694	putative PBP binding loops; other site
452863010695	ABC-ATPase subunit interface; other site
452863010696	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
452863010697	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863010698	Walker A/P-loop; other site
452863010699	ATP binding site [chemical binding]; other site
452863010700	Q-loop/lid; other site
452863010701	ABC transporter signature motif; other site
452863010702	Walker B; other site
452863010703	D-loop; other site
452863010704	H-loop/switch region; other site
452863010705	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
452863010706	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
452863010707	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863010708	Walker A/P-loop; other site
452863010709	ATP binding site [chemical binding]; other site
452863010710	Q-loop/lid; other site
452863010711	ABC transporter signature motif; other site
452863010712	Walker B; other site
452863010713	D-loop; other site
452863010714	H-loop/switch region; other site
452863010715	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863010716	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
452863010717	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
452863010718	inhibitor site; inhibition site
452863010719	active site
452863010720	dimer interface [polypeptide binding]; other site
452863010721	catalytic residue [active]
452863010722	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863010723	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
452863010724	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
452863010725	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
452863010726	putative active site cavity [active]
452863010727	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
452863010728	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863010729	active site
452863010730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
452863010731	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
452863010732	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
452863010733	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
452863010734	RibD C-terminal domain; Region: RibD_C; cl17279
452863010735	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
452863010736	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
452863010737	active site
452863010738	trimer interface [polypeptide binding]; other site
452863010739	allosteric site; other site
452863010740	active site lid [active]
452863010741	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863010742	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863010743	DNA-binding site [nucleotide binding]; DNA binding site
452863010744	FCD domain; Region: FCD; pfam07729
452863010745	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
452863010746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863010747	ATP binding site [chemical binding]; other site
452863010748	Mg2+ binding site [ion binding]; other site
452863010749	G-X-G motif; other site
452863010750	Predicted flavoprotein [General function prediction only]; Region: COG0431
452863010751	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
452863010752	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
452863010753	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863010754	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
452863010755	NodB motif; other site
452863010756	active site
452863010757	catalytic site [active]
452863010758	metal binding site [ion binding]; metal-binding site
452863010759	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
452863010760	putative hydrophobic ligand binding site [chemical binding]; other site
452863010761	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
452863010762	metal binding site [ion binding]; metal-binding site
452863010763	active site
452863010764	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863010765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010766	putative substrate translocation pore; other site
452863010767	hypothetical protein; Provisional; Region: PRK07079
452863010768	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
452863010769	metal binding site [ion binding]; metal-binding site
452863010770	putative dimer interface [polypeptide binding]; other site
452863010771	Uncharacterized conserved protein [Function unknown]; Region: COG1284
452863010772	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
452863010773	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
452863010774	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
452863010775	threonine dehydratase; Provisional; Region: PRK08246
452863010776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
452863010777	catalytic residue [active]
452863010778	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
452863010779	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
452863010780	active site
452863010781	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
452863010782	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
452863010783	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863010784	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863010785	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863010786	benzoate transport; Region: 2A0115; TIGR00895
452863010787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010788	putative substrate translocation pore; other site
452863010789	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
452863010790	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
452863010791	active site
452863010792	Domain of unknown function (DUF222); Region: DUF222; pfam02720
452863010793	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
452863010794	active site
452863010795	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
452863010796	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
452863010797	iron-sulfur cluster [ion binding]; other site
452863010798	[2Fe-2S] cluster binding site [ion binding]; other site
452863010799	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863010800	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
452863010801	AsnC family; Region: AsnC_trans_reg; pfam01037
452863010802	MarR family; Region: MarR_2; pfam12802
452863010803	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863010804	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
452863010805	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
452863010806	metal binding site [ion binding]; metal-binding site
452863010807	dimer interface [polypeptide binding]; other site
452863010808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010809	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863010810	putative substrate translocation pore; other site
452863010811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
452863010812	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
452863010813	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
452863010814	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
452863010815	glyoxylate carboligase; Provisional; Region: PRK11269
452863010816	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
452863010817	PYR/PP interface [polypeptide binding]; other site
452863010818	dimer interface [polypeptide binding]; other site
452863010819	TPP binding site [chemical binding]; other site
452863010820	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
452863010821	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
452863010822	TPP-binding site [chemical binding]; other site
452863010823	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
452863010824	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
452863010825	allantoinase; Region: allantoinase; TIGR03178
452863010826	active site
452863010827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
452863010828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
452863010829	DNA binding site [nucleotide binding]
452863010830	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
452863010831	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
452863010832	catalytic triad [active]
452863010833	Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337
452863010834	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
452863010835	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
452863010836	catalytic triad [active]
452863010837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863010838	Coenzyme A binding pocket [chemical binding]; other site
452863010839	A new structural DNA glycosylase; Region: AlkD_like; cd06561
452863010840	active site
452863010841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863010842	Response regulator receiver domain; Region: Response_reg; pfam00072
452863010843	active site
452863010844	phosphorylation site [posttranslational modification]
452863010845	intermolecular recognition site; other site
452863010846	dimerization interface [polypeptide binding]; other site
452863010847	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
452863010848	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
452863010849	DXD motif; other site
452863010850	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863010851	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
452863010852	anti sigma factor interaction site; other site
452863010853	regulatory phosphorylation site [posttranslational modification]; other site
452863010854	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
452863010855	GAF domain; Region: GAF; pfam01590
452863010856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
452863010857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
452863010858	dimer interface [polypeptide binding]; other site
452863010859	phosphorylation site [posttranslational modification]
452863010860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863010861	ATP binding site [chemical binding]; other site
452863010862	Mg2+ binding site [ion binding]; other site
452863010863	G-X-G motif; other site
452863010864	putative OHCU decarboxylase; Provisional; Region: PRK13798
452863010865	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
452863010866	active site
452863010867	homotetramer interface [polypeptide binding]; other site
452863010868	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863010869	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863010870	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863010871	BCCT family transporter; Region: BCCT; pfam02028
452863010872	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863010873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863010874	DNA-binding site [nucleotide binding]; DNA binding site
452863010875	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
452863010876	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
452863010877	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
452863010878	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
452863010879	putative active site [active]
452863010880	putative substrate binding site [chemical binding]; other site
452863010881	putative cosubstrate binding site; other site
452863010882	catalytic site [active]
452863010883	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
452863010884	hydroxyglutarate oxidase; Provisional; Region: PRK11728
452863010885	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
452863010886	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863010887	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
452863010888	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
452863010889	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
452863010890	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
452863010891	homodimer interface [polypeptide binding]; other site
452863010892	NADP binding site [chemical binding]; other site
452863010893	substrate binding site [chemical binding]; other site
452863010894	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
452863010895	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
452863010896	dimer interface [polypeptide binding]; other site
452863010897	putative functional site; other site
452863010898	putative MPT binding site; other site
452863010899	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
452863010900	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
452863010901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863010902	putative substrate translocation pore; other site
452863010903	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
452863010904	hydroxyglutarate oxidase; Provisional; Region: PRK11728
452863010905	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
452863010906	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
452863010907	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863010908	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
452863010909	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
452863010910	putative molybdopterin cofactor binding site [chemical binding]; other site
452863010911	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
452863010912	putative molybdopterin cofactor binding site; other site
452863010913	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
452863010914	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
452863010915	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
452863010916	NAD binding site [chemical binding]; other site
452863010917	catalytic Zn binding site [ion binding]; other site
452863010918	substrate binding site [chemical binding]; other site
452863010919	structural Zn binding site [ion binding]; other site
452863010920	amidophosphoribosyltransferase; Provisional; Region: PRK07847
452863010921	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
452863010922	active site
452863010923	tetramer interface [polypeptide binding]; other site
452863010924	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
452863010925	active site
452863010926	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
452863010927	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
452863010928	dimerization interface [polypeptide binding]; other site
452863010929	putative ATP binding site [chemical binding]; other site
452863010930	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863010931	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863010932	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
452863010933	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
452863010934	Septum formation; Region: Septum_form; pfam13845
452863010935	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
452863010936	Clp amino terminal domain; Region: Clp_N; pfam02861
452863010937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863010938	Walker A motif; other site
452863010939	ATP binding site [chemical binding]; other site
452863010940	Walker B motif; other site
452863010941	arginine finger; other site
452863010942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863010943	Walker A motif; other site
452863010944	ATP binding site [chemical binding]; other site
452863010945	Walker B motif; other site
452863010946	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
452863010947	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
452863010948	cleavage site
452863010949	active site
452863010950	substrate binding sites [chemical binding]; other site
452863010951	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
452863010952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010953	Walker A/P-loop; other site
452863010954	ATP binding site [chemical binding]; other site
452863010955	Q-loop/lid; other site
452863010956	ABC transporter signature motif; other site
452863010957	Walker B; other site
452863010958	D-loop; other site
452863010959	H-loop/switch region; other site
452863010960	TOBE domain; Region: TOBE; pfam03459
452863010961	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
452863010962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863010963	putative PBP binding loops; other site
452863010964	ABC-ATPase subunit interface; other site
452863010965	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
452863010966	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
452863010967	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
452863010968	DNA binding residues [nucleotide binding]
452863010969	TOBE domain; Region: TOBE; cl01440
452863010970	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
452863010971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
452863010972	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
452863010973	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
452863010974	hypothetical protein; Provisional; Region: PRK11770
452863010975	Domain of unknown function (DUF307); Region: DUF307; pfam03733
452863010976	Domain of unknown function (DUF307); Region: DUF307; pfam03733
452863010977	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
452863010978	active site
452863010979	HutD; Region: HutD; pfam05962
452863010980	Ferritin-like domain; Region: Ferritin; pfam00210
452863010981	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
452863010982	ferroxidase diiron center [ion binding]; other site
452863010983	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
452863010984	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
452863010985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863010986	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
452863010987	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
452863010988	active site
452863010989	Walker A/P-loop; other site
452863010990	ATP binding site [chemical binding]; other site
452863010991	choline dehydrogenase; Validated; Region: PRK02106
452863010992	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
452863010993	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863010994	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863010995	NAD(P) binding site [chemical binding]; other site
452863010996	catalytic residues [active]
452863010997	BCCT family transporter; Region: BCCT; cl00569
452863010998	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
452863010999	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
452863011000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
452863011001	DEAD-like helicases superfamily; Region: DEXDc; smart00487
452863011002	ATP binding site [chemical binding]; other site
452863011003	putative Mg++ binding site [ion binding]; other site
452863011004	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863011005	nucleotide binding region [chemical binding]; other site
452863011006	ATP-binding site [chemical binding]; other site
452863011007	Methyltransferase domain; Region: Methyltransf_31; pfam13847
452863011008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863011009	S-adenosylmethionine binding site [chemical binding]; other site
452863011010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011011	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863011012	putative substrate translocation pore; other site
452863011013	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
452863011014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863011016	S-adenosylmethionine binding site [chemical binding]; other site
452863011017	Fimbrial protein; Region: Fimbrial; cl01416
452863011018	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863011019	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
452863011020	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
452863011021	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
452863011022	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
452863011023	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863011024	DNA binding residues [nucleotide binding]
452863011025	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
452863011026	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
452863011027	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
452863011028	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
452863011029	DNA binding residues [nucleotide binding]
452863011030	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
452863011031	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
452863011032	ATP binding site [chemical binding]; other site
452863011033	putative Mg++ binding site [ion binding]; other site
452863011034	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
452863011035	nucleotide binding region [chemical binding]; other site
452863011036	ATP-binding site [chemical binding]; other site
452863011037	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
452863011038	active site
452863011039	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
452863011040	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
452863011041	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863011042	non-specific DNA binding site [nucleotide binding]; other site
452863011043	salt bridge; other site
452863011044	sequence-specific DNA binding site [nucleotide binding]; other site
452863011045	Cupin domain; Region: Cupin_2; pfam07883
452863011046	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
452863011047	allantoate amidohydrolase; Reviewed; Region: PRK09290
452863011048	active site
452863011049	metal binding site [ion binding]; metal-binding site
452863011050	dimer interface [polypeptide binding]; other site
452863011051	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
452863011052	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
452863011053	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
452863011054	active site
452863011055	FMN binding site [chemical binding]; other site
452863011056	substrate binding site [chemical binding]; other site
452863011057	3Fe-4S cluster binding site [ion binding]; other site
452863011058	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
452863011059	domain_subunit interface; other site
452863011060	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
452863011061	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
452863011062	putative active site [active]
452863011063	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
452863011064	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
452863011065	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
452863011066	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
452863011067	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
452863011068	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
452863011069	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863011070	pyranose oxidase; Region: pyranose_ox; TIGR02462
452863011071	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
452863011072	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
452863011073	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
452863011074	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
452863011075	active site
452863011076	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863011077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011078	dimer interface [polypeptide binding]; other site
452863011079	conserved gate region; other site
452863011080	putative PBP binding loops; other site
452863011081	ABC-ATPase subunit interface; other site
452863011082	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
452863011083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011084	dimer interface [polypeptide binding]; other site
452863011085	conserved gate region; other site
452863011086	putative PBP binding loops; other site
452863011087	ABC-ATPase subunit interface; other site
452863011088	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863011089	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863011090	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
452863011091	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
452863011092	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
452863011093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011095	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
452863011096	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863011097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863011098	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863011099	dimerization interface [polypeptide binding]; other site
452863011100	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
452863011101	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863011102	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
452863011103	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
452863011104	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
452863011105	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
452863011106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011108	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
452863011109	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
452863011110	active site
452863011111	metal binding site [ion binding]; metal-binding site
452863011112	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
452863011113	active site
452863011114	metal binding site [ion binding]; metal-binding site
452863011115	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863011116	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863011117	Putative cyclase; Region: Cyclase; pfam04199
452863011118	hypothetical protein; Provisional; Region: PRK07236
452863011119	hypothetical protein; Provisional; Region: PRK06847
452863011120	Amidohydrolase; Region: Amidohydro_2; pfam04909
452863011121	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
452863011122	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
452863011123	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863011124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863011125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863011126	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
452863011127	substrate binding pocket [chemical binding]; other site
452863011128	dimerization interface [polypeptide binding]; other site
452863011129	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863011130	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863011131	DNA binding residues [nucleotide binding]
452863011132	dimerization interface [polypeptide binding]; other site
452863011133	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863011134	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
452863011135	DXD motif; other site
452863011136	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
452863011137	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863011138	putative active site [active]
452863011139	putative metal binding site [ion binding]; other site
452863011140	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
452863011141	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
452863011142	putative active site [active]
452863011143	putative metal binding site [ion binding]; other site
452863011144	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
452863011145	active site
452863011146	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863011147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863011148	NAD(P) binding site [chemical binding]; other site
452863011149	active site
452863011150	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
452863011151	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
452863011152	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
452863011153	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
452863011154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863011155	Walker A motif; other site
452863011156	ATP binding site [chemical binding]; other site
452863011157	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
452863011158	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863011159	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863011160	DNA binding residues [nucleotide binding]
452863011161	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
452863011162	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863011163	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863011164	DNA binding residues [nucleotide binding]
452863011165	dimerization interface [polypeptide binding]; other site
452863011166	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
452863011167	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
452863011168	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863011169	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863011170	ligand binding site [chemical binding]; other site
452863011171	dimerization interface [polypeptide binding]; other site
452863011172	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
452863011173	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
452863011174	putative ligand binding site [chemical binding]; other site
452863011175	putative NAD binding site [chemical binding]; other site
452863011176	catalytic site [active]
452863011177	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863011178	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863011179	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
452863011180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011181	putative PBP binding loops; other site
452863011182	ABC-ATPase subunit interface; other site
452863011183	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863011184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011185	dimer interface [polypeptide binding]; other site
452863011186	conserved gate region; other site
452863011187	putative PBP binding loops; other site
452863011188	ABC-ATPase subunit interface; other site
452863011189	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
452863011190	tyramine oxidase; Provisional; Region: tynA; PRK11504
452863011191	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
452863011192	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
452863011193	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
452863011194	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011195	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011196	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
452863011197	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
452863011198	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
452863011199	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
452863011200	glutamate dehydrogenase; Provisional; Region: PRK09414
452863011201	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
452863011202	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
452863011203	NAD(P) binding site [chemical binding]; other site
452863011204	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
452863011205	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
452863011206	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
452863011207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863011209	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
452863011210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011211	maltose O-acetyltransferase; Provisional; Region: PRK10092
452863011212	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
452863011213	active site
452863011214	substrate binding site [chemical binding]; other site
452863011215	trimer interface [polypeptide binding]; other site
452863011216	CoA binding site [chemical binding]; other site
452863011217	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
452863011218	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863011219	NAD(P) binding site [chemical binding]; other site
452863011220	catalytic residues [active]
452863011221	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
452863011222	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
452863011223	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
452863011224	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
452863011225	inhibitor site; inhibition site
452863011226	active site
452863011227	dimer interface [polypeptide binding]; other site
452863011228	catalytic residue [active]
452863011229	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
452863011230	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863011231	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863011232	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863011233	DNA-binding site [nucleotide binding]; DNA binding site
452863011234	FCD domain; Region: FCD; pfam07729
452863011235	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
452863011236	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
452863011237	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
452863011238	putative active site [active]
452863011239	putative substrate binding site [chemical binding]; other site
452863011240	putative cosubstrate binding site; other site
452863011241	catalytic site [active]
452863011242	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
452863011243	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
452863011244	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
452863011245	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
452863011246	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
452863011247	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
452863011248	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
452863011249	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
452863011250	sarcosine oxidase, delta subunit family, heterotetrameric form; Region: soxD; TIGR01374
452863011251	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
452863011252	hydroxyglutarate oxidase; Provisional; Region: PRK11728
452863011253	hydroxyglutarate oxidase; Provisional; Region: PRK11728
452863011254	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
452863011255	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
452863011256	dimer interface [polypeptide binding]; other site
452863011257	active site
452863011258	glycine-pyridoxal phosphate binding site [chemical binding]; other site
452863011259	folate binding site [chemical binding]; other site
452863011260	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863011261	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863011262	DNA-binding site [nucleotide binding]; DNA binding site
452863011263	FCD domain; Region: FCD; pfam07729
452863011264	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863011265	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863011266	active site
452863011267	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863011268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
452863011269	nucleotide binding site [chemical binding]; other site
452863011270	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
452863011271	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
452863011272	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
452863011273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011274	dimer interface [polypeptide binding]; other site
452863011275	conserved gate region; other site
452863011276	putative PBP binding loops; other site
452863011277	ABC-ATPase subunit interface; other site
452863011278	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
452863011279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011280	dimer interface [polypeptide binding]; other site
452863011281	conserved gate region; other site
452863011282	putative PBP binding loops; other site
452863011283	ABC-ATPase subunit interface; other site
452863011284	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
452863011285	active site
452863011286	catalytic site [active]
452863011287	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
452863011288	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
452863011289	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
452863011290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
452863011291	nucleotide binding site [chemical binding]; other site
452863011292	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
452863011293	trehalose synthase; Region: treS_nterm; TIGR02456
452863011294	active site
452863011295	catalytic site [active]
452863011296	prephenate dehydratase; Provisional; Region: PRK11899
452863011297	Prephenate dehydratase; Region: PDT; pfam00800
452863011298	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
452863011299	putative L-Phe binding site [chemical binding]; other site
452863011300	phenol 2-monooxygenase; Provisional; Region: PRK08294
452863011301	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
452863011302	dimer interface [polypeptide binding]; other site
452863011303	hypothetical protein; Provisional; Region: PRK12764
452863011304	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
452863011305	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
452863011306	Transcriptional regulators [Transcription]; Region: GntR; COG1802
452863011307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863011308	DNA-binding site [nucleotide binding]; DNA binding site
452863011309	FCD domain; Region: FCD; pfam07729
452863011310	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
452863011311	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
452863011312	NAD binding site [chemical binding]; other site
452863011313	catalytic residues [active]
452863011314	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
452863011315	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
452863011316	tetramer interface [polypeptide binding]; other site
452863011317	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
452863011318	tetramer interface [polypeptide binding]; other site
452863011319	active site
452863011320	metal binding site [ion binding]; metal-binding site
452863011321	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
452863011322	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
452863011323	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
452863011324	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
452863011325	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863011326	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
452863011327	NAD(P) binding site [chemical binding]; other site
452863011328	catalytic residues [active]
452863011329	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
452863011330	DNA binding residues [nucleotide binding]
452863011331	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
452863011332	putative dimer interface [polypeptide binding]; other site
452863011333	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
452863011334	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
452863011335	HSP70 interaction site [polypeptide binding]; other site
452863011336	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
452863011337	dimer interface [polypeptide binding]; other site
452863011338	heat shock protein GrpE; Provisional; Region: PRK14140
452863011339	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
452863011340	dimer interface [polypeptide binding]; other site
452863011341	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
452863011342	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
452863011343	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
452863011344	nucleotide binding site [chemical binding]; other site
452863011345	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
452863011346	glutaminase; Provisional; Region: PRK00971
452863011347	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863011348	dimerization interface [polypeptide binding]; other site
452863011349	putative DNA binding site [nucleotide binding]; other site
452863011350	putative Zn2+ binding site [ion binding]; other site
452863011351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863011355	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
452863011356	NAD(P) binding site [chemical binding]; other site
452863011357	active site
452863011358	MMPL family; Region: MMPL; pfam03176
452863011359	Protein export membrane protein; Region: SecD_SecF; cl14618
452863011360	MMPL family; Region: MMPL; pfam03176
452863011361	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863011362	MarR family; Region: MarR_2; pfam12802
452863011363	MarR family; Region: MarR_2; cl17246
452863011364	Methyltransferase domain; Region: Methyltransf_23; pfam13489
452863011365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
452863011366	S-adenosylmethionine binding site [chemical binding]; other site
452863011367	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
452863011368	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
452863011369	putative active site [active]
452863011370	LysE type translocator; Region: LysE; cl00565
452863011371	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
452863011372	Low molecular weight phosphatase family; Region: LMWPc; cd00115
452863011373	active site
452863011374	hypothetical protein; Provisional; Region: PRK06547
452863011375	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
452863011376	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
452863011377	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
452863011378	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
452863011379	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
452863011380	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
452863011381	putative active site [active]
452863011382	catalytic site [active]
452863011383	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
452863011384	putative active site [active]
452863011385	catalytic site [active]
452863011386	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
452863011387	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
452863011388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863011389	catalytic residue [active]
452863011390	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
452863011391	tetracycline repressor protein TetR; Provisional; Region: PRK13756
452863011392	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011393	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
452863011394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
452863011395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
452863011396	OpgC protein; Region: OpgC_C; pfam10129
452863011397	Acyltransferase family; Region: Acyl_transf_3; pfam01757
452863011398	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
452863011399	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
452863011400	active site residue [active]
452863011401	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
452863011402	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
452863011403	homodimer interface [polypeptide binding]; other site
452863011404	substrate-cofactor binding pocket; other site
452863011405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863011406	catalytic residue [active]
452863011407	carboxylate-amine ligase; Provisional; Region: PRK13517
452863011408	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
452863011409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
452863011410	non-specific DNA binding site [nucleotide binding]; other site
452863011411	salt bridge; other site
452863011412	sequence-specific DNA binding site [nucleotide binding]; other site
452863011413	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
452863011414	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
452863011415	putative active site [active]
452863011416	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
452863011417	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
452863011418	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863011419	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863011420	Walker A/P-loop; other site
452863011421	ATP binding site [chemical binding]; other site
452863011422	Q-loop/lid; other site
452863011423	ABC transporter signature motif; other site
452863011424	Walker B; other site
452863011425	D-loop; other site
452863011426	H-loop/switch region; other site
452863011427	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
452863011428	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
452863011429	Walker A/P-loop; other site
452863011430	ATP binding site [chemical binding]; other site
452863011431	Q-loop/lid; other site
452863011432	ABC transporter signature motif; other site
452863011433	Walker B; other site
452863011434	D-loop; other site
452863011435	H-loop/switch region; other site
452863011436	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
452863011437	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
452863011438	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
452863011439	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
452863011440	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
452863011441	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
452863011442	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
452863011443	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
452863011444	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
452863011445	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
452863011446	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
452863011447	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
452863011448	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
452863011449	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
452863011450	TrkA-C domain; Region: TrkA_C; pfam02080
452863011451	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
452863011452	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
452863011453	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
452863011454	trimer interface [polypeptide binding]; other site
452863011455	active site
452863011456	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
452863011457	Family description; Region: VCBS; pfam13517
452863011458	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
452863011459	putative hydrophobic ligand binding site [chemical binding]; other site
452863011460	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
452863011461	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
452863011462	putative active site [active]
452863011463	putative ligand binding site [chemical binding]; other site
452863011464	putative NAD(P) binding site [chemical binding]; other site
452863011465	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
452863011466	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
452863011467	metal binding site [ion binding]; metal-binding site
452863011468	putative dimer interface [polypeptide binding]; other site
452863011469	H+ Antiporter protein; Region: 2A0121; TIGR00900
452863011470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863011472	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
452863011473	dimerization interface [polypeptide binding]; other site
452863011474	Proline dehydrogenase; Region: Pro_dh; cl03282
452863011475	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863011476	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863011477	NAD(P) binding site [chemical binding]; other site
452863011478	catalytic residues [active]
452863011479	amino acid transporter; Region: 2A0306; TIGR00909
452863011480	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
452863011481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
452863011482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
452863011483	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
452863011484	putative dimerization interface [polypeptide binding]; other site
452863011485	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
452863011486	tetramerization interface [polypeptide binding]; other site
452863011487	active site
452863011488	Predicted permeases [General function prediction only]; Region: COG0679
452863011489	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
452863011490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011491	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863011492	putative substrate translocation pore; other site
452863011493	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
452863011494	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
452863011495	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
452863011496	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
452863011497	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863011498	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863011499	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863011500	active site
452863011501	catalytic tetrad [active]
452863011502	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
452863011503	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
452863011504	potential catalytic triad [active]
452863011505	conserved cys residue [active]
452863011506	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863011507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863011508	substrate binding pocket [chemical binding]; other site
452863011509	membrane-bound complex binding site; other site
452863011510	hinge residues; other site
452863011511	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
452863011512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011513	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
452863011514	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
452863011515	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
452863011516	NAD(P) binding site [chemical binding]; other site
452863011517	catalytic residues [active]
452863011518	choline dehydrogenase; Validated; Region: PRK02106
452863011519	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
452863011520	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
452863011521	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
452863011522	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
452863011523	[2Fe-2S] cluster binding site [ion binding]; other site
452863011524	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
452863011525	putative alpha subunit interface [polypeptide binding]; other site
452863011526	putative active site [active]
452863011527	putative substrate binding site [chemical binding]; other site
452863011528	Fe binding site [ion binding]; other site
452863011529	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
452863011530	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
452863011531	FAD binding pocket [chemical binding]; other site
452863011532	FAD binding motif [chemical binding]; other site
452863011533	phosphate binding motif [ion binding]; other site
452863011534	beta-alpha-beta structure motif; other site
452863011535	NAD binding pocket [chemical binding]; other site
452863011536	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
452863011537	catalytic loop [active]
452863011538	iron binding site [ion binding]; other site
452863011539	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
452863011540	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
452863011541	NAD binding site [chemical binding]; other site
452863011542	catalytic Zn binding site [ion binding]; other site
452863011543	structural Zn binding site [ion binding]; other site
452863011544	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
452863011545	classical (c) SDRs; Region: SDR_c; cd05233
452863011546	NAD(P) binding site [chemical binding]; other site
452863011547	active site
452863011548	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
452863011549	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
452863011550	AP (apurinic/apyrimidinic) site pocket; other site
452863011551	DNA interaction; other site
452863011552	Metal-binding active site; metal-binding site
452863011553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011554	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863011555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011556	AAA domain; Region: AAA_33; pfam13671
452863011557	AAA domain; Region: AAA_17; pfam13207
452863011558	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
452863011559	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
452863011560	active site
452863011561	intersubunit interface [polypeptide binding]; other site
452863011562	catalytic residue [active]
452863011563	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863011564	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863011565	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863011566	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863011567	DNA binding site [nucleotide binding]
452863011568	domain linker motif; other site
452863011569	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863011570	ligand binding site [chemical binding]; other site
452863011571	dimerization interface [polypeptide binding]; other site
452863011572	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
452863011573	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
452863011574	active site
452863011575	metal binding site [ion binding]; metal-binding site
452863011576	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863011577	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
452863011578	Metal-binding active site; metal-binding site
452863011579	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
452863011580	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863011581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863011582	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
452863011583	classical (c) SDRs; Region: SDR_c; cd05233
452863011584	NAD(P) binding site [chemical binding]; other site
452863011585	active site
452863011586	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
452863011587	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
452863011588	active site
452863011589	non-prolyl cis peptide bond; other site
452863011590	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
452863011591	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
452863011592	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
452863011593	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
452863011594	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
452863011595	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
452863011596	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
452863011597	substrate binding pocket [chemical binding]; other site
452863011598	membrane-bound complex binding site; other site
452863011599	hinge residues; other site
452863011600	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
452863011601	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
452863011602	Walker A/P-loop; other site
452863011603	ATP binding site [chemical binding]; other site
452863011604	Q-loop/lid; other site
452863011605	ABC transporter signature motif; other site
452863011606	Walker B; other site
452863011607	D-loop; other site
452863011608	H-loop/switch region; other site
452863011609	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
452863011610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011611	dimer interface [polypeptide binding]; other site
452863011612	conserved gate region; other site
452863011613	putative PBP binding loops; other site
452863011614	ABC-ATPase subunit interface; other site
452863011615	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
452863011616	AAA-like domain; Region: AAA_10; pfam12846
452863011617	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
452863011618	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
452863011619	putative active site [active]
452863011620	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
452863011621	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
452863011622	NHL repeat; Region: NHL; pfam01436
452863011623	Copper resistance protein D; Region: CopD; pfam05425
452863011624	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
452863011625	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
452863011626	IHF dimer interface [polypeptide binding]; other site
452863011627	IHF - DNA interface [nucleotide binding]; other site
452863011628	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
452863011629	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
452863011630	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
452863011631	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
452863011632	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
452863011633	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863011634	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863011635	DNA binding site [nucleotide binding]
452863011636	domain linker motif; other site
452863011637	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
452863011638	ligand binding site [chemical binding]; other site
452863011639	dimerization interface [polypeptide binding]; other site
452863011640	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
452863011641	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
452863011642	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
452863011643	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
452863011644	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
452863011645	FAD binding pocket [chemical binding]; other site
452863011646	FAD binding motif [chemical binding]; other site
452863011647	phosphate binding motif [ion binding]; other site
452863011648	beta-alpha-beta structure motif; other site
452863011649	NAD binding pocket [chemical binding]; other site
452863011650	FMN-binding domain; Region: FMN_bind; cl01081
452863011651	ApbE family; Region: ApbE; pfam02424
452863011652	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
452863011653	active site
452863011654	catalytic triad [active]
452863011655	oxyanion hole [active]
452863011656	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863011657	MarR family; Region: MarR_2; cl17246
452863011658	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
452863011659	active site
452863011660	catalytic triad [active]
452863011661	oxyanion hole [active]
452863011662	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
452863011663	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
452863011664	FAD binding pocket [chemical binding]; other site
452863011665	FAD binding motif [chemical binding]; other site
452863011666	phosphate binding motif [ion binding]; other site
452863011667	NAD binding pocket [chemical binding]; other site
452863011668	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
452863011669	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
452863011670	Walker A/P-loop; other site
452863011671	ATP binding site [chemical binding]; other site
452863011672	Q-loop/lid; other site
452863011673	ABC transporter signature motif; other site
452863011674	Walker B; other site
452863011675	D-loop; other site
452863011676	H-loop/switch region; other site
452863011677	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
452863011678	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
452863011679	dimer interface [polypeptide binding]; other site
452863011680	putative PBP binding regions; other site
452863011681	ABC-ATPase subunit  interface; other site
452863011682	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
452863011683	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
452863011684	ABC-ATPase subunit  interface; other site
452863011685	dimer interface [polypeptide binding]; other site
452863011686	putative PBP binding regions; other site
452863011687	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
452863011688	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
452863011689	siderophore binding site; other site
452863011690	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
452863011691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
452863011692	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
452863011693	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
452863011694	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
452863011695	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
452863011696	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
452863011697	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
452863011698	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
452863011699	active site
452863011700	hypothetical protein; Provisional; Region: PRK04233
452863011701	SEC-C motif; Region: SEC-C; pfam02810
452863011702	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
452863011703	active site 2 [active]
452863011704	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
452863011705	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
452863011706	active site
452863011707	catalytic tetrad [active]
452863011708	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
452863011709	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
452863011710	NADP binding site [chemical binding]; other site
452863011711	sulfite oxidase; Provisional; Region: PLN00177
452863011712	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
452863011713	Moco binding site; other site
452863011714	metal coordination site [ion binding]; other site
452863011715	dimerization interface [polypeptide binding]; other site
452863011716	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
452863011717	RNA binding surface [nucleotide binding]; other site
452863011718	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
452863011719	active site
452863011720	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
452863011721	putative uracil binding site [chemical binding]; other site
452863011722	putative active site [active]
452863011723	HipA N-terminal domain; Region: Couple_hipA; pfam13657
452863011724	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
452863011725	HipA-like N-terminal domain; Region: HipA_N; pfam07805
452863011726	HipA-like C-terminal domain; Region: HipA_C; pfam07804
452863011727	transcriptional regulator, y4mF family; Region: couple_hipB; TIGR03070
452863011728	Transcriptional regulators [Transcription]; Region: FadR; COG2186
452863011729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
452863011730	DNA-binding site [nucleotide binding]; DNA binding site
452863011731	FCD domain; Region: FCD; pfam07729
452863011732	L-asparaginase II; Region: Asparaginase_II; pfam06089
452863011733	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
452863011734	Aspartase; Region: Aspartase; cd01357
452863011735	active sites [active]
452863011736	tetramer interface [polypeptide binding]; other site
452863011737	L-asparagine permease; Provisional; Region: PRK15049
452863011738	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
452863011739	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
452863011740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863011741	Coenzyme A binding pocket [chemical binding]; other site
452863011742	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
452863011743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
452863011744	Walker A motif; other site
452863011745	ATP binding site [chemical binding]; other site
452863011746	Walker B motif; other site
452863011747	arginine finger; other site
452863011748	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
452863011749	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
452863011750	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
452863011751	active site
452863011752	HIGH motif; other site
452863011753	nucleotide binding site [chemical binding]; other site
452863011754	active site
452863011755	KMSKS motif; other site
452863011756	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863011757	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
452863011758	putative DNA binding site [nucleotide binding]; other site
452863011759	putative Zn2+ binding site [ion binding]; other site
452863011760	AsnC family; Region: AsnC_trans_reg; pfam01037
452863011761	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
452863011762	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
452863011763	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863011764	putative DNA binding site [nucleotide binding]; other site
452863011765	putative Zn2+ binding site [ion binding]; other site
452863011766	AsnC family; Region: AsnC_trans_reg; pfam01037
452863011767	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
452863011768	SnoaL-like domain; Region: SnoaL_2; pfam12680
452863011769	Protein of unknown function (DUF456); Region: DUF456; pfam04306
452863011770	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
452863011771	Malic enzyme, N-terminal domain; Region: malic; pfam00390
452863011772	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
452863011773	NAD(P) binding pocket [chemical binding]; other site
452863011774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011776	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
452863011777	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
452863011778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011779	Major Facilitator Superfamily; Region: MFS_1; pfam07690
452863011780	putative substrate translocation pore; other site
452863011781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011782	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
452863011783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011784	putative substrate translocation pore; other site
452863011785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011786	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
452863011787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863011788	Walker A/P-loop; other site
452863011789	ATP binding site [chemical binding]; other site
452863011790	Q-loop/lid; other site
452863011791	ABC transporter signature motif; other site
452863011792	Walker B; other site
452863011793	D-loop; other site
452863011794	H-loop/switch region; other site
452863011795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863011796	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863011797	MarR family; Region: MarR; pfam01047
452863011798	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
452863011799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863011800	Coenzyme A binding pocket [chemical binding]; other site
452863011801	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
452863011802	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
452863011803	Walker A/P-loop; other site
452863011804	ATP binding site [chemical binding]; other site
452863011805	Q-loop/lid; other site
452863011806	ABC transporter signature motif; other site
452863011807	Walker B; other site
452863011808	D-loop; other site
452863011809	H-loop/switch region; other site
452863011810	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
452863011811	ABC-ATPase subunit  interface; other site
452863011812	dimer interface [polypeptide binding]; other site
452863011813	putative PBP binding regions; other site
452863011814	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
452863011815	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
452863011816	ABC-ATPase subunit  interface; other site
452863011817	dimer interface [polypeptide binding]; other site
452863011818	putative PBP binding regions; other site
452863011819	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
452863011820	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
452863011821	putative ligand binding residues [chemical binding]; other site
452863011822	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
452863011823	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
452863011824	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
452863011825	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
452863011826	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
452863011827	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
452863011828	active site
452863011829	P-loop; other site
452863011830	phosphorylation site [posttranslational modification]
452863011831	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
452863011832	active site
452863011833	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011834	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011835	WHG domain; Region: WHG; pfam13305
452863011836	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
452863011837	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
452863011838	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
452863011839	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
452863011840	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
452863011841	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
452863011842	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
452863011843	active site
452863011844	substrate binding [chemical binding]; other site
452863011845	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
452863011846	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
452863011847	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
452863011848	substrate binding [chemical binding]; other site
452863011849	active site
452863011850	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
452863011851	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
452863011852	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863011853	Walker A/P-loop; other site
452863011854	ATP binding site [chemical binding]; other site
452863011855	Q-loop/lid; other site
452863011856	ABC transporter signature motif; other site
452863011857	Walker B; other site
452863011858	D-loop; other site
452863011859	H-loop/switch region; other site
452863011860	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
452863011861	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
452863011862	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863011863	Walker A/P-loop; other site
452863011864	ATP binding site [chemical binding]; other site
452863011865	Q-loop/lid; other site
452863011866	ABC transporter signature motif; other site
452863011867	Walker B; other site
452863011868	D-loop; other site
452863011869	H-loop/switch region; other site
452863011870	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863011871	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863011872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011873	dimer interface [polypeptide binding]; other site
452863011874	conserved gate region; other site
452863011875	putative PBP binding loops; other site
452863011876	ABC-ATPase subunit interface; other site
452863011877	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
452863011878	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
452863011879	substrate binding site [chemical binding]; other site
452863011880	Transcriptional regulators [Transcription]; Region: PurR; COG1609
452863011881	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
452863011882	DNA binding site [nucleotide binding]
452863011883	domain linker motif; other site
452863011884	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
452863011885	putative dimerization interface [polypeptide binding]; other site
452863011886	putative ligand binding site [chemical binding]; other site
452863011887	Helix-turn-helix domain; Region: HTH_17; pfam12728
452863011888	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
452863011889	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
452863011890	catalytic site [active]
452863011891	TAP-like protein; Region: Abhydrolase_4; pfam08386
452863011892	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
452863011893	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
452863011894	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
452863011895	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
452863011896	hexamer interface [polypeptide binding]; other site
452863011897	ligand binding site [chemical binding]; other site
452863011898	putative active site [active]
452863011899	NAD(P) binding site [chemical binding]; other site
452863011900	putative oxidoreductase; Provisional; Region: PRK11579
452863011901	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863011902	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
452863011903	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
452863011904	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
452863011905	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
452863011906	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863011907	Walker A/P-loop; other site
452863011908	ATP binding site [chemical binding]; other site
452863011909	Q-loop/lid; other site
452863011910	ABC transporter signature motif; other site
452863011911	Walker B; other site
452863011912	D-loop; other site
452863011913	H-loop/switch region; other site
452863011914	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
452863011915	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
452863011916	Walker A/P-loop; other site
452863011917	ATP binding site [chemical binding]; other site
452863011918	Q-loop/lid; other site
452863011919	ABC transporter signature motif; other site
452863011920	Walker B; other site
452863011921	D-loop; other site
452863011922	H-loop/switch region; other site
452863011923	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
452863011924	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
452863011925	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
452863011926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011927	dimer interface [polypeptide binding]; other site
452863011928	conserved gate region; other site
452863011929	putative PBP binding loops; other site
452863011930	ABC-ATPase subunit interface; other site
452863011931	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
452863011932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863011933	dimer interface [polypeptide binding]; other site
452863011934	conserved gate region; other site
452863011935	putative PBP binding loops; other site
452863011936	ABC-ATPase subunit interface; other site
452863011937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
452863011938	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
452863011939	Predicted flavoprotein [General function prediction only]; Region: COG0431
452863011940	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
452863011941	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
452863011942	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863011943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863011944	homodimer interface [polypeptide binding]; other site
452863011945	catalytic residue [active]
452863011946	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863011947	Ligand Binding Site [chemical binding]; other site
452863011948	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
452863011949	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
452863011950	E3 interaction surface; other site
452863011951	lipoyl attachment site [posttranslational modification]; other site
452863011952	e3 binding domain; Region: E3_binding; pfam02817
452863011953	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
452863011954	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
452863011955	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
452863011956	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
452863011957	alpha subunit interface [polypeptide binding]; other site
452863011958	TPP binding site [chemical binding]; other site
452863011959	heterodimer interface [polypeptide binding]; other site
452863011960	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
452863011961	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
452863011962	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
452863011963	tetramer interface [polypeptide binding]; other site
452863011964	TPP-binding site [chemical binding]; other site
452863011965	heterodimer interface [polypeptide binding]; other site
452863011966	phosphorylation loop region [posttranslational modification]
452863011967	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
452863011968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863011969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863011970	homodimer interface [polypeptide binding]; other site
452863011971	catalytic residue [active]
452863011972	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
452863011973	active site
452863011974	catalytic triad [active]
452863011975	Pectinesterase; Region: Pectinesterase; pfam01095
452863011976	putative pectinesterase; Region: PLN02432; cl01911
452863011977	Amb_all domain; Region: Amb_all; smart00656
452863011978	Membrane protein of unknown function; Region: DUF360; pfam04020
452863011979	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
452863011980	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
452863011981	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
452863011982	adenylosuccinate lyase; Provisional; Region: PRK09285
452863011983	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
452863011984	tetramer interface [polypeptide binding]; other site
452863011985	active site
452863011986	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863011987	catalytic core [active]
452863011988	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
452863011989	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
452863011990	active site
452863011991	ATP binding site [chemical binding]; other site
452863011992	substrate binding site [chemical binding]; other site
452863011993	activation loop (A-loop); other site
452863011994	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
452863011995	MarR family; Region: MarR; pfam01047
452863011996	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
452863011997	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
452863011998	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
452863011999	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
452863012000	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
452863012001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863012002	Walker A/P-loop; other site
452863012003	ATP binding site [chemical binding]; other site
452863012004	Q-loop/lid; other site
452863012005	ABC transporter signature motif; other site
452863012006	Walker B; other site
452863012007	D-loop; other site
452863012008	H-loop/switch region; other site
452863012009	TOBE domain; Region: TOBE_2; pfam08402
452863012010	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
452863012011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863012012	dimer interface [polypeptide binding]; other site
452863012013	conserved gate region; other site
452863012014	putative PBP binding loops; other site
452863012015	ABC-ATPase subunit interface; other site
452863012016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
452863012017	dimer interface [polypeptide binding]; other site
452863012018	conserved gate region; other site
452863012019	putative PBP binding loops; other site
452863012020	ABC-ATPase subunit interface; other site
452863012021	hypothetical protein; Provisional; Region: PRK06753
452863012022	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863012023	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863012024	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
452863012025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863012026	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
452863012027	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863012028	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
452863012029	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863012030	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
452863012031	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
452863012032	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
452863012033	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
452863012034	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
452863012035	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
452863012036	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
452863012037	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
452863012038	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
452863012039	ligand binding site [chemical binding]; other site
452863012040	homodimer interface [polypeptide binding]; other site
452863012041	NAD(P) binding site [chemical binding]; other site
452863012042	trimer interface B [polypeptide binding]; other site
452863012043	trimer interface A [polypeptide binding]; other site
452863012044	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
452863012045	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
452863012046	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863012047	Coenzyme A transferase; Region: CoA_trans; cl17247
452863012048	Coenzyme A transferase; Region: CoA_trans; cl17247
452863012049	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
452863012050	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
452863012051	dimer interface [polypeptide binding]; other site
452863012052	active site
452863012053	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
452863012054	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
452863012055	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
452863012056	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
452863012057	tetramer interface [polypeptide binding]; other site
452863012058	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
452863012059	heterodimer interface [polypeptide binding]; other site
452863012060	active site
452863012061	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
452863012062	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
452863012063	active site
452863012064	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
452863012065	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
452863012066	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
452863012067	dimer interface [polypeptide binding]; other site
452863012068	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
452863012069	active site
452863012070	Fe binding site [ion binding]; other site
452863012071	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
452863012072	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
452863012073	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
452863012074	shikimate binding site; other site
452863012075	NAD(P) binding site [chemical binding]; other site
452863012076	Transcriptional regulator [Transcription]; Region: IclR; COG1414
452863012077	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
452863012078	putative DNA binding site [nucleotide binding]; other site
452863012079	putative Zn2+ binding site [ion binding]; other site
452863012080	Bacterial transcriptional regulator; Region: IclR; pfam01614
452863012081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
452863012082	metabolite-proton symporter; Region: 2A0106; TIGR00883
452863012083	putative substrate translocation pore; other site
452863012084	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
452863012085	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
452863012086	active site
452863012087	DNA binding site [nucleotide binding]
452863012088	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
452863012089	DNA binding site [nucleotide binding]
452863012090	Membrane transport protein; Region: Mem_trans; cl09117
452863012091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
452863012092	Coenzyme A binding pocket [chemical binding]; other site
452863012093	aminotransferase AlaT; Validated; Region: PRK09265
452863012094	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
452863012095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863012096	homodimer interface [polypeptide binding]; other site
452863012097	catalytic residue [active]
452863012098	Ubiquitin-like proteins; Region: UBQ; cl00155
452863012099	charged pocket; other site
452863012100	hydrophobic patch; other site
452863012101	VPS10 domain; Region: VPS10; smart00602
452863012102	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
452863012103	active site
452863012104	catalytic site [active]
452863012105	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
452863012106	Ligand Binding Site [chemical binding]; other site
452863012107	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
452863012108	putative homotetramer interface [polypeptide binding]; other site
452863012109	putative homodimer interface [polypeptide binding]; other site
452863012110	putative allosteric switch controlling residues; other site
452863012111	putative metal binding site [ion binding]; other site
452863012112	putative homodimer-homodimer interface [polypeptide binding]; other site
452863012113	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
452863012114	metal-binding site [ion binding]
452863012115	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
452863012116	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
452863012117	metal-binding site [ion binding]
452863012118	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
452863012119	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
452863012120	Proteins of 100 residues with WXG; Region: WXG100; cl02005
452863012121	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
452863012122	EamA-like transporter family; Region: EamA; pfam00892
452863012123	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
452863012124	CGNR zinc finger; Region: zf-CGNR; pfam11706
452863012125	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
452863012126	putative efflux protein, MATE family; Region: matE; TIGR00797
452863012127	DoxX; Region: DoxX; cl17842
452863012128	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
452863012129	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
452863012130	replicative DNA helicase; Region: DnaB; TIGR00665
452863012131	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
452863012132	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
452863012133	Walker A motif; other site
452863012134	ATP binding site [chemical binding]; other site
452863012135	Walker B motif; other site
452863012136	DNA binding loops [nucleotide binding]
452863012137	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
452863012138	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
452863012139	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
452863012140	Cupin domain; Region: Cupin_2; cl17218
452863012141	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
452863012142	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
452863012143	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
452863012144	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
452863012145	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
452863012146	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
452863012147	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
452863012148	dimer interface [polypeptide binding]; other site
452863012149	ssDNA binding site [nucleotide binding]; other site
452863012150	tetramer (dimer of dimers) interface [polypeptide binding]; other site
452863012151	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
452863012152	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
452863012153	Spore germination protein; Region: Spore_permease; cl17796
452863012154	AAA ATPase domain; Region: AAA_16; pfam13191
452863012155	Walker A motif; other site
452863012156	ATP binding site [chemical binding]; other site
452863012157	Walker B motif; other site
452863012158	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863012159	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863012160	DNA binding residues [nucleotide binding]
452863012161	dimerization interface [polypeptide binding]; other site
452863012162	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
452863012163	Bacterial sugar transferase; Region: Bac_transf; pfam02397
452863012164	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
452863012165	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
452863012166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
452863012167	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
452863012168	NAD(P) binding site [chemical binding]; other site
452863012169	active site
452863012170	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
452863012171	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
452863012172	inhibitor-cofactor binding pocket; inhibition site
452863012173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863012174	catalytic residue [active]
452863012175	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
452863012176	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
452863012177	putative trimer interface [polypeptide binding]; other site
452863012178	putative CoA binding site [chemical binding]; other site
452863012179	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
452863012180	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
452863012181	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
452863012182	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
452863012183	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
452863012184	inhibitor-cofactor binding pocket; inhibition site
452863012185	pyridoxal 5'-phosphate binding site [chemical binding]; other site
452863012186	catalytic residue [active]
452863012187	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
452863012188	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
452863012189	active site
452863012190	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
452863012191	Chain length determinant protein; Region: Wzz; cl15801
452863012192	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
452863012193	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
452863012194	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
452863012195	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
452863012196	Probable Catalytic site; other site
452863012197	metal-binding site
452863012198	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863012199	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
452863012200	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
452863012201	active site
452863012202	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
452863012203	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
452863012204	Bacterial Ig-like domain; Region: Big_5; pfam13205
452863012205	Bacterial Ig-like domain; Region: Big_5; pfam13205
452863012206	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
452863012207	Bacterial Ig-like domain; Region: Big_5; pfam13205
452863012208	Bacterial Ig-like domain; Region: Big_5; pfam13205
452863012209	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
452863012210	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
452863012211	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
452863012212	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
452863012213	active site
452863012214	metal binding site [ion binding]; metal-binding site
452863012215	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
452863012216	putative active site [active]
452863012217	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
452863012218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
452863012219	active site
452863012220	phosphorylation site [posttranslational modification]
452863012221	intermolecular recognition site; other site
452863012222	dimerization interface [polypeptide binding]; other site
452863012223	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
452863012224	DNA binding residues [nucleotide binding]
452863012225	dimerization interface [polypeptide binding]; other site
452863012226	Histidine kinase; Region: HisKA_3; pfam07730
452863012227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
452863012228	ATP binding site [chemical binding]; other site
452863012229	Mg2+ binding site [ion binding]; other site
452863012230	G-X-G motif; other site
452863012231	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
452863012232	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
452863012233	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
452863012234	Walker A/P-loop; other site
452863012235	ATP binding site [chemical binding]; other site
452863012236	Q-loop/lid; other site
452863012237	ABC transporter signature motif; other site
452863012238	Walker B; other site
452863012239	D-loop; other site
452863012240	H-loop/switch region; other site
452863012241	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
452863012242	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
452863012243	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
452863012244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
452863012245	Walker A/P-loop; other site
452863012246	ATP binding site [chemical binding]; other site
452863012247	Q-loop/lid; other site
452863012248	ABC transporter signature motif; other site
452863012249	Walker B; other site
452863012250	D-loop; other site
452863012251	H-loop/switch region; other site
452863012252	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
452863012253	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
452863012254	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
452863012255	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
452863012256	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
452863012257	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
452863012258	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
452863012259	Predicted integral membrane protein [Function unknown]; Region: COG5650
452863012260	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
452863012261	catalytic core [active]
452863012262	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
452863012263	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
452863012264	active site
452863012265	NTP binding site [chemical binding]; other site
452863012266	metal binding triad [ion binding]; metal-binding site
452863012267	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
452863012268	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
452863012269	Zn2+ binding site [ion binding]; other site
452863012270	Mg2+ binding site [ion binding]; other site
452863012271	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
452863012272	active site
452863012273	Ap6A binding site [chemical binding]; other site
452863012274	nudix motif; other site
452863012275	metal binding site [ion binding]; metal-binding site
452863012276	integral membrane protein MviN; Region: mviN; TIGR01695
452863012277	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
452863012278	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
452863012279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
452863012280	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
452863012281	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
452863012282	catalytic residues [active]
452863012283	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
452863012284	ParB-like nuclease domain; Region: ParBc; pfam02195
452863012285	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
452863012286	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
452863012287	Magnesium ion binding site [ion binding]; other site
452863012288	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
452863012289	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
452863012290	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
452863012291	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
452863012292	G-X-X-G motif; other site
452863012293	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
452863012294	RxxxH motif; other site
452863012295	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
452863012296	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
452863012297	Haemolytic domain; Region: Haemolytic; pfam01809
452863012298	Ribonuclease P; Region: Ribonuclease_P; pfam00825